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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Brucella]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-136 1.97e-36

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 121.81  E-value: 1.97e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489058347   4 EADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIEGYTVRIAPEFERDLVRAHVLVTALPKLAPKVETA 83
Cdd:COG1522    5 EIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFAEA 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489058347  84 LRSMMAVRTLHSVSGHFDMIVVVEAPSIQELDAVL-DRIGALEGVERTMSSIIL 136
Cdd:COG1522   85 LAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-136 1.97e-36

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 121.81  E-value: 1.97e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489058347   4 EADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIEGYTVRIAPEFERDLVRAHVLVTALPKLAPKVETA 83
Cdd:COG1522    5 EIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFAEA 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489058347  84 LRSMMAVRTLHSVSGHFDMIVVVEAPSIQELDAVL-DRIGALEGVERTMSSIIL 136
Cdd:COG1522   85 LAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-108 1.10e-23

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 88.34  E-value: 1.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489058347     4 EADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIEGYTVRIAPEFERDLVRAHVLVTALPKLAP-KVET 82
Cdd:smart00344   3 EIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLeEFLE 82

                           90       100
                   ....*....|....*....|....*.
gi 489058347    83 ALRSMMAVRTLHSVSGHFDMIVVVEA 108
Cdd:smart00344  83 KLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 6-142 4.27e-13

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 62.42  E-value: 4.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489058347   6 DLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIEGYTVRIAPE---FERDLVRAHVLVTAlpKLAPKVET 82
Cdd:PRK11179  11 DRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKqlgYDVCCFIGIILKSA--KDYPSALA 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489058347  83 ALRSMMAVRTLHSVSGHFDMIVVVEAPSIQELDAVL-DRIGALEGVERTMSSIILSTRIDR 142
Cdd:PRK11179  89 KLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLiNKIQTIDEIQSTETLISLQNPIMR 149
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
6-43 4.25e-11

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 54.30  E-value: 4.25e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 489058347    6 DLALISLLRENARASTADLARRLGVSRTTVQSRIEKLE 43
Cdd:pfam13404   4 DRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 1-51 7.76e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 38.82  E-value: 7.76e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489058347   1 MTTEADLALISLLRENaRASTADLARRLGVSRTTVQSRIEKLEKRGVIEGY 51
Cdd:cd00090    4 LSDPTRLRILRLLLEG-PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-136 1.97e-36

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 121.81  E-value: 1.97e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489058347   4 EADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIEGYTVRIAPEFERDLVRAHVLVTALPKLAPKVETA 83
Cdd:COG1522    5 EIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFAEA 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489058347  84 LRSMMAVRTLHSVSGHFDMIVVVEAPSIQELDAVL-DRIGALEGVERTMSSIIL 136
Cdd:COG1522   85 LAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-108 1.10e-23

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 88.34  E-value: 1.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489058347     4 EADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIEGYTVRIAPEFERDLVRAHVLVTALPKLAP-KVET 82
Cdd:smart00344   3 EIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLeEFLE 82

                           90       100
                   ....*....|....*....|....*.
gi 489058347    83 ALRSMMAVRTLHSVSGHFDMIVVVEA 108
Cdd:smart00344  83 KLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 6-142 4.27e-13

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 62.42  E-value: 4.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489058347   6 DLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIEGYTVRIAPE---FERDLVRAHVLVTAlpKLAPKVET 82
Cdd:PRK11179  11 DRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKqlgYDVCCFIGIILKSA--KDYPSALA 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489058347  83 ALRSMMAVRTLHSVSGHFDMIVVVEAPSIQELDAVL-DRIGALEGVERTMSSIILSTRIDR 142
Cdd:PRK11179  89 KLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLiNKIQTIDEIQSTETLISLQNPIMR 149
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
6-43 4.25e-11

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 54.30  E-value: 4.25e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 489058347    6 DLALISLLRENARASTADLARRLGVSRTTVQSRIEKLE 43
Cdd:pfam13404   4 DRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 78-138 7.10e-11

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 54.45  E-value: 7.10e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489058347   78 PKVETALRSMMAVRTLHSVSGHFDMIVVVEAPSIQELDAVLDR-IGALEGVERTMSSIILST 138
Cdd:pfam01037  12 EEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREkLRSLPGVARTETSIVLST 73
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
4-48 1.05e-10

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 53.21  E-value: 1.05e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 489058347    4 EADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVI 48
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
6-101 7.09e-09

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 51.30  E-value: 7.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489058347   6 DLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIEGYTVRIAPEFERDLVRAHVLVTaLPKLAPKV----E 81
Cdd:PRK11169  16 DRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEIT-LNRGAPDVfeqfN 94

                         90       100
                 ....*....|....*....|
gi 489058347  82 TALRSMMAVRTLHSVSGHFD 101
Cdd:PRK11169  95 AAVQKLEEIQECHLVSGDFD 114
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
4-49 6.71e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 43.33  E-value: 6.71e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 489058347   4 EADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:COG3398   97 ETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVE 142
BirA COG1654
Biotin operon repressor [Transcription];
1-47 2.94e-05

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 42.28  E-value: 2.94e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 489058347   1 MTTEADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGV 47
Cdd:COG1654    1 MMSSTRLKLLRLLADGEFHSGEELAEELGVSRAAVWKHIKALRELGY 47
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 3-49 7.46e-05

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 38.74  E-value: 7.46e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 489058347   3 TEADLALISLLRENA-RASTADLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:COG2512   14 LEDERRVLELLRENGgRMTQSEIVKETGWSKSKVSRLLSRLEERGLIE 61
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 1-51 7.76e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 38.82  E-value: 7.76e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489058347   1 MTTEADLALISLLRENaRASTADLARRLGVSRTTVQSRIEKLEKRGVIEGY 51
Cdd:cd00090    4 LSDPTRLRILRLLLEG-PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
8-54 7.80e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 40.68  E-value: 7.80e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 489058347   8 ALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIEGYTVR 54
Cdd:COG2345   17 RILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETER 63
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
12-49 1.90e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 39.03  E-value: 1.90e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 489058347  12 LLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:COG1321   18 LSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVE 55
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 7-48 2.04e-04

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 37.03  E-value: 2.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 489058347    7 LALISLLRENARA-STADLARRLGVSRTTVQSRIEKLEKRGVI 48
Cdd:pfam08279   1 LQILQLLLEARGPiSGQELAEKLGVSRRTIRRDIKILEELGVP 43
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
3-49 2.36e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.96  E-value: 2.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 489058347     3 TEADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:smart00347   9 TPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVR 55
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-49 2.60e-04

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 39.35  E-value: 2.60e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 489058347   1 MTTEADLALI-SLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:COG1349    1 MLAEERRQKIlELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLR 50
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 3-49 4.10e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 36.41  E-value: 4.10e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 489058347    3 TEADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:pfam12802   4 TPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVE 50
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 20-54 4.17e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 36.66  E-value: 4.17e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 489058347  20 STADLARRLGVSRTTVQSRIEKLEKRGVIE-----GYTVR 54
Cdd:cd07377   27 SERELAEELGVSRTTVREALRELEAEGLVErrpgrGTFVA 66
NapD COG3062
Cytoplasmic chaperone NapD for the signal peptide of periplasmic nitrate reductase NapAB ...
 68-127 5.17e-04

Cytoplasmic chaperone NapD for the signal peptide of periplasmic nitrate reductase NapAB [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442296  Cd Length: 86  Bit Score: 36.75  E-value: 5.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489058347  68 VLVTALPKLAPKVETALRSMMAVrTLHSVSGHFDMIVVVEAPSIQELDAVLDRIGALEGV 127
Cdd:COG3062   10 LVVQARPERLEAVAAALAALPGV-EVHASSEEGKLVVVIEAESQGALLDTIEAIRALPGV 68
NapD pfam03927
NapD protein; Uncharacterized protein involved in formation of periplasmic nitrate reductase.
 68-127 5.93e-04

NapD protein; Uncharacterized protein involved in formation of periplasmic nitrate reductase.


Pssm-ID: 427593  Cd Length: 71  Bit Score: 36.30  E-value: 5.93e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489058347   68 VLVTALPKLAPKVETALRSMMAVrTLHSVSGHFDMIVVVEAPSIQELDAVLDRIGALEGV 127
Cdd:pfam03927   4 LVVQVRPERLAAVKEALAALPGV-EVHAEDEEGKLVVVIEAESQGEILDIIDAINALPGV 62
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 3-49 6.32e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 35.99  E-value: 6.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 489058347    3 TEADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:pfam01047   2 TLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIE 48
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 7-120 6.33e-04

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 38.52  E-value: 6.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489058347   7 LALISLLRENARASTADLARRLGVSRTTVQSRIEKLE--------KRGVIEGYtvRIAPEFERDLVR-----AHVLVTAL 73
Cdd:COG2378    8 LALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRelgvpieaERGRGGGY--RLRDGYRLPPLMlteeeALALLLAL 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489058347  74 --------PKLAPKVETA---LRSMMAVRTLHSVSGHFDMIVVVEAPSIQE------LDAVLDR 120
Cdd:COG2378   86 rllaalggAPLAEAAASAlakLEAVLPERLRERLEALAERVGVDPPPEVDPevletlREAIRER 149
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
3-49 7.24e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 37.26  E-value: 7.24e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 489058347   3 TEADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:COG1846   37 TPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
7-49 7.61e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 37.95  E-value: 7.61e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 489058347   7 LALISLLRENARaSTADLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:COG4742   19 KNILLLLAEGPK-TRSELAESLDVSRSTILRQLKELEERGLIE 60
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 8-49 8.62e-04

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 35.43  E-value: 8.62e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 489058347    8 ALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:pfam01325   9 TIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYVD 50
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
3-49 1.32e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 36.48  E-value: 1.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 489058347   3 TEADLALISLLRENARASTAD-LARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:COG3355   26 SETDAEVYLILLENGEPLTVEeLAEALDRSRSTVYRSLQKLLEAGLVE 73
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 3-49 1.37e-03

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 35.19  E-value: 1.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 489058347    3 TEADLALISLLRENARAStaDLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:pfam01978   9 YEAKVYLALLKLGPATAD--EIAEESGVPRSKVYEVLRSLEDKGLVE 53
PRK11886 PRK11886
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;
2-74 1.68e-03

bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;


Pssm-ID: 237010 [Multi-domain]  Cd Length: 319  Bit Score: 37.07  E-value: 1.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489058347   2 TTEADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGV-IE-----GYtvRIAPEFerDLVRAHVLVTALP 74
Cdd:PRK11886   2 TYTVMLQLLSLLADGDFHSGEQLGEELGISRAAIWKHIQTLEEWGLdIFsvkgkGY--RLAEPL--DLLDPERISSQLP 76
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
7-49 2.50e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 35.32  E-value: 2.50e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 489058347   7 LALISLLRENARaSTADLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:COG4189   22 LRILRLLAEEPL-NVNELAEALGLPKSTVSYHIRKLEEAGLIR 63
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 20-54 2.86e-03

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 36.73  E-value: 2.86e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 489058347  20 STADLARRLGVSRTTVQSRIEKLEKRGVIE-----GYTVR 54
Cdd:COG1167   38 SSRELAAQLGVSRSTVVRAYEELEAEGLIEsrpgsGTFVA 77
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
7-54 2.90e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 35.39  E-value: 2.90e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 489058347   7 LALISLLREnARASTADLARRLGVSRTTVQSRIEKLEKRGVIEGYTVR 54
Cdd:COG1777   20 RRILALLSE-EPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREG 66
HTH_36 pfam13730
Helix-turn-helix domain;
1-48 3.04e-03

Helix-turn-helix domain;


Pssm-ID: 463970 [Multi-domain]  Cd Length: 55  Bit Score: 34.00  E-value: 3.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489058347    1 MTTEADLALISLLR-----ENARASTADLARRLGVSRTTVQSRIEKLEKRGVI 48
Cdd:pfam13730   3 LSPTAKLLLLILASyankdGGCFPSVETLAKRLGLSRRTIQRAIKELEELGYL 55
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 7-54 3.93e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 33.67  E-value: 3.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 489058347    7 LALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIEGYTVR 54
Cdd:pfam12840  13 LRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
PriA COG1198
Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, ...
 3-89 4.12e-03

Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440811 [Multi-domain]  Cd Length: 728  Bit Score: 36.25  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489058347   3 TEADLALISLLRENARA-STADLARRLGVSRTTVQSriekLEKRGVIEgytvRIAPEFERDLVRAHVLVTALPKLAPKVE 81
Cdd:COG1198  130 APKQRRVLEALREHGGPlTLSELAKEAGVSRSVLKA----LVKKGLLE----IEEREVDRDPFAPDVPAEPPPTLNEEQQ 201


                 ....*...
gi 489058347  82 TALRSMMA 89
Cdd:COG1198  202 AAVEAIRA 209
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 3-49 7.35e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 35.05  E-value: 7.35e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 489058347   3 TEADLALISLLRENARASTADLARRLGVSRTTVQSRIEKLEKRGVIE 49
Cdd:cd09655  138 SREELKILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLVE 184
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
10-41 7.43e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 33.28  E-value: 7.43e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 489058347  10 ISLLRENARASTADLARRLGVSRTTVqSRIEK 41
Cdd:COG1476    9 LKELRKERGLTQEELAELLGVSRQTI-SAIEN 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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