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Conserved domains on  [gi|489059473|ref|WP_002969539|]
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MULTISPECIES: DNA gyrase inhibitor YacG [Brucella]

Protein Classification

DNA gyrase inhibitor YacG( domain architecture ID 10011674)

DNA gyrase inhibitor YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK01343 PRK01343
zinc-binding protein; Provisional
 13-69 1.94e-31

zinc-binding protein; Provisional


:

Pssm-ID: 234943  Cd Length: 57  Bit Score: 103.63  E-value: 1.94e-31
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 489059473 13 AKVAPLRPTRPCPECGKPSTREAYPFCSPRCKNIDLNRWLSGSYVIAGKPLGEEDEN 69
Cdd:PRK01343  1 AKVEPLRPTRPCPECGKPSTREAYPFCSERCRDIDLNRWLSGSYVIPGAPDEEDDEE 57
 
Name Accession Description Interval E-value
PRK01343 PRK01343
zinc-binding protein; Provisional
 13-69 1.94e-31

zinc-binding protein; Provisional


Pssm-ID: 234943  Cd Length: 57  Bit Score: 103.63  E-value: 1.94e-31
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 489059473 13 AKVAPLRPTRPCPECGKPSTREAYPFCSPRCKNIDLNRWLSGSYVIAGKPLGEEDEN 69
Cdd:PRK01343  1 AKVEPLRPTRPCPECGKPSTREAYPFCSERCRDIDLNRWLSGSYVIPGAPDEEDDEE 57
YacG COG3024
Endogenous inhibitor of DNA gyrase, YacG/DUF329 family [Replication, recombination and repair]; ...
 19-71 1.57e-19

Endogenous inhibitor of DNA gyrase, YacG/DUF329 family [Replication, recombination and repair];


Pssm-ID: 442260  Cd Length: 58  Bit Score: 73.46  E-value: 1.57e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 489059473 19 RPTRPCPECGKPST----REAYPFCSPRCKNIDLNRWLSGSYVIAGKPLGEEDENDS 71
Cdd:COG3024   1 MTKVPCPICGKPVEwspeNPYRPFCSKRCKLIDLGRWLSEEYRIPGEPLDDDEEDPE 57
YacG pfam03884
DNA gyrase inhibitor YacG; YacG inhibits all the catalytic activities of DNA gyrase by ...
 23-65 4.63e-10

DNA gyrase inhibitor YacG; YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. YacG has been shown to bind zinc and contains the structural motifs typical of zinc-binding proteins. The conserved four cysteine motif in this protein (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures.


Pssm-ID: 427566  Cd Length: 48  Bit Score: 49.18  E-value: 4.63e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 489059473  23 PCPECGKPSTREAY----PFCSPRCKNIDLNRWLSGSYVIAGKPLGE 65
Cdd:pfam03884  2 RCPTCGKPVEWSPEnpfrPFCSERCKLIDLGAWADEEYRIPGEPPPD 48
 
Name Accession Description Interval E-value
PRK01343 PRK01343
zinc-binding protein; Provisional
 13-69 1.94e-31

zinc-binding protein; Provisional


Pssm-ID: 234943  Cd Length: 57  Bit Score: 103.63  E-value: 1.94e-31
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 489059473 13 AKVAPLRPTRPCPECGKPSTREAYPFCSPRCKNIDLNRWLSGSYVIAGKPLGEEDEN 69
Cdd:PRK01343  1 AKVEPLRPTRPCPECGKPSTREAYPFCSERCRDIDLNRWLSGSYVIPGAPDEEDDEE 57
YacG COG3024
Endogenous inhibitor of DNA gyrase, YacG/DUF329 family [Replication, recombination and repair]; ...
 19-71 1.57e-19

Endogenous inhibitor of DNA gyrase, YacG/DUF329 family [Replication, recombination and repair];


Pssm-ID: 442260  Cd Length: 58  Bit Score: 73.46  E-value: 1.57e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 489059473 19 RPTRPCPECGKPST----REAYPFCSPRCKNIDLNRWLSGSYVIAGKPLGEEDENDS 71
Cdd:COG3024   1 MTKVPCPICGKPVEwspeNPYRPFCSKRCKLIDLGRWLSEEYRIPGEPLDDDEEDPE 57
YacG pfam03884
DNA gyrase inhibitor YacG; YacG inhibits all the catalytic activities of DNA gyrase by ...
 23-65 4.63e-10

DNA gyrase inhibitor YacG; YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. YacG has been shown to bind zinc and contains the structural motifs typical of zinc-binding proteins. The conserved four cysteine motif in this protein (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures.


Pssm-ID: 427566  Cd Length: 48  Bit Score: 49.18  E-value: 4.63e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 489059473  23 PCPECGKPSTREAY----PFCSPRCKNIDLNRWLSGSYVIAGKPLGE 65
Cdd:pfam03884  2 RCPTCGKPVEWSPEnpfrPFCSERCKLIDLGAWADEEYRIPGEPPPD 48
PRK00418 PRK00418
DNA gyrase inhibitor YacG;
21-68 6.53e-07

DNA gyrase inhibitor YacG;


Pssm-ID: 234754  Cd Length: 62  Bit Score: 41.56  E-value: 6.53e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 489059473 21 TRPCPECGKP---STREAY-PFCSPRCKNIDLNRWLSGSYVIAGKPLGEEDE 68
Cdd:PRK00418  6 TVNCPTCGKPvewGEISPFrPFCSKRCQLIDLGEWAAEEKRIPSSGDLSESD 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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