NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489079861|ref|WP_002989798|]
View 

peptide chain release factor N(5)-glutamine methyltransferase [Streptococcus pyogenes]

Protein Classification

HemK/PrmC family methyltransferase( domain architecture ID 11483836)

HemK/PrmC family methyltransferase is a class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; such as peptide chain release factor N(5)-glutamine methyltransferase that methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0003676|GO:0032259|GO:1904047
PubMed:  12741815|12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-272 9.48e-106

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


:

Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 308.24  E-value: 9.48e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861   1 MNYATLIRTYEDKLEqidEDRENLAYVFREIKEWSSLDMLIHQNQAVTPEDAVLLEHIFCSLSQHLSPQYITGNAYFRDL 80
Cdd:PRK09328   2 MTIAEALREATARLA---SPRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  81 KLAVDKRVLIPRPETEELVDMIL-AENLDAPLNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQLD 159
Cdd:PRK09328  79 DFKVSPGVLIPRPETEELVEWALeALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 160 -ITFIESDVFS-LISGTFDIIVSNPPYISYEDKEEVSLNVLQSEPHLALFAKENGYAIYRKIIEQADNYLTKEGKLYFEI 237
Cdd:PRK09328 159 rVEFLQGDWFEpLPGGRFDLIVSNPPYIPEADIHLLQPEVRDHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLLEI 238

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 489079861 238 GYKQAEGIKDMLQAYFPQRhIRVVTDIFGKERMVV 272
Cdd:PRK09328 239 GYDQGEAVRALLAAAGFAD-VETRKDLAGRDRVVL 272
 
Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-272 9.48e-106

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 308.24  E-value: 9.48e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861   1 MNYATLIRTYEDKLEqidEDRENLAYVFREIKEWSSLDMLIHQNQAVTPEDAVLLEHIFCSLSQHLSPQYITGNAYFRDL 80
Cdd:PRK09328   2 MTIAEALREATARLA---SPRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  81 KLAVDKRVLIPRPETEELVDMIL-AENLDAPLNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQLD 159
Cdd:PRK09328  79 DFKVSPGVLIPRPETEELVEWALeALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 160 -ITFIESDVFS-LISGTFDIIVSNPPYISYEDKEEVSLNVLQSEPHLALFAKENGYAIYRKIIEQADNYLTKEGKLYFEI 237
Cdd:PRK09328 159 rVEFLQGDWFEpLPGGRFDLIVSNPPYIPEADIHLLQPEVRDHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLLEI 238

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 489079861 238 GYKQAEGIKDMLQAYFPQRhIRVVTDIFGKERMVV 272
Cdd:PRK09328 239 GYDQGEAVRALLAAAGFAD-VETRKDLAGRDRVVL 272
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 26-272 1.24e-105

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 307.09  E-value: 1.24e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861   26 YVFREIKEWSSLDMLIHQNQAVTPEDAVLLEHIFCSLSQHLSPQYITGNAYFRDLKLAVDKRVLIPRPETEELVDMILAE 105
Cdd:TIGR03534   4 LLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAALER 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  106 NLDAPlNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQLD-ITFIESDVFS-LISGTFDIIVSNPP 183
Cdd:TIGR03534  84 LKKGP-RVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLEnVEFLQGDWFEpLPSGKFDLIVSNPP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  184 YISYEDKEEVSLNVLQSEPHLALFAKENGYAIYRKIIEQADNYLTKEGKLYFEIGYKQAEGIKDMLQAYfPQRHIRVVTD 263
Cdd:TIGR03534 163 YIPEADIHLLDPEVRDFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAA-GFADVETRKD 241


                  ....*....
gi 489079861  264 IFGKERMVV 272
Cdd:TIGR03534 242 LAGKDRVVL 250
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 1-272 2.07e-103

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 302.45  E-value: 2.07e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861   1 MNYATLIRTYEDKLEQ--IDEDRENLAYVFREIKEWSSLDMLIHQNQAVTPEDAVLLEHIFCSLSQHLSPQYITGNAYFR 78
Cdd:COG2890    1 MTIRELLRWAAARLAAagVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  79 DLKLAVDKRVLIPRPETEELVDMILAE-NLDAPLNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQ 157
Cdd:COG2890   81 GLEFKVDPGVLIPRPETEELVELALALlPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 158 LD--ITFIESDVFSLIS--GTFDIIVSNPPYISYEDKEEVSLNVLQSEPHLALFAKENGYAIYRKIIEQADNYLTKEGKL 233
Cdd:COG2890  161 LEdrVRFLQGDLFEPLPgdGRFDLIVSNPPYIPEDEIALLPPEVRDHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWL 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 489079861 234 YFEIGYKQAEGIKDMLQAYFpQRHIRVVTDIFGKERMVV 272
Cdd:COG2890  241 LLEIGEDQGEAVRALLEAAG-FADVETHKDLAGRDRVVV 278
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 102-242 1.59e-22

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 91.11  E-value: 1.59e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  102 ILAENLDAPL--NVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQLD-ITFIESDVFS-LISGTFDI 177
Cdd:pfam05175  22 LLLEHLPKDLsgKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLEnGEVVASDVYSgVEDGKFDL 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489079861  178 IVSNPPYISyedkeevslnvlqsephlalfAKENGYAIYRKIIEQADNYLTKEGKLYFEI----GYKQA 242
Cdd:pfam05175 102 IISNPPFHA---------------------GLATTYNVAQRFIADAKRHLRPGGELWIVAnrflGYPPL 149
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 112-189 3.30e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 64.37  E-value: 3.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 112 NVLDIGTGSGAIAISLkKERPNWQVTASDISRAALDLAKANADAYQLD-ITFIESDVFSLIS---GTFDIIVSNPPYISY 187
Cdd:cd02440    1 RVLDLGCGTGALALAL-ASGPGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEELPPeadESFDVIISDPPLHHL 79


                 ..
gi 489079861 188 ED 189
Cdd:cd02440   80 VE 81
 
Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-272 9.48e-106

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 308.24  E-value: 9.48e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861   1 MNYATLIRTYEDKLEqidEDRENLAYVFREIKEWSSLDMLIHQNQAVTPEDAVLLEHIFCSLSQHLSPQYITGNAYFRDL 80
Cdd:PRK09328   2 MTIAEALREATARLA---SPRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  81 KLAVDKRVLIPRPETEELVDMIL-AENLDAPLNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQLD 159
Cdd:PRK09328  79 DFKVSPGVLIPRPETEELVEWALeALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 160 -ITFIESDVFS-LISGTFDIIVSNPPYISYEDKEEVSLNVLQSEPHLALFAKENGYAIYRKIIEQADNYLTKEGKLYFEI 237
Cdd:PRK09328 159 rVEFLQGDWFEpLPGGRFDLIVSNPPYIPEADIHLLQPEVRDHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLLEI 238

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 489079861 238 GYKQAEGIKDMLQAYFPQRhIRVVTDIFGKERMVV 272
Cdd:PRK09328 239 GYDQGEAVRALLAAAGFAD-VETRKDLAGRDRVVL 272
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 26-272 1.24e-105

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 307.09  E-value: 1.24e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861   26 YVFREIKEWSSLDMLIHQNQAVTPEDAVLLEHIFCSLSQHLSPQYITGNAYFRDLKLAVDKRVLIPRPETEELVDMILAE 105
Cdd:TIGR03534   4 LLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAALER 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  106 NLDAPlNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQLD-ITFIESDVFS-LISGTFDIIVSNPP 183
Cdd:TIGR03534  84 LKKGP-RVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLEnVEFLQGDWFEpLPSGKFDLIVSNPP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  184 YISYEDKEEVSLNVLQSEPHLALFAKENGYAIYRKIIEQADNYLTKEGKLYFEIGYKQAEGIKDMLQAYfPQRHIRVVTD 263
Cdd:TIGR03534 163 YIPEADIHLLDPEVRDFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAA-GFADVETRKD 241


                  ....*....
gi 489079861  264 IFGKERMVV 272
Cdd:TIGR03534 242 LAGKDRVVL 250
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 1-272 2.07e-103

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 302.45  E-value: 2.07e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861   1 MNYATLIRTYEDKLEQ--IDEDRENLAYVFREIKEWSSLDMLIHQNQAVTPEDAVLLEHIFCSLSQHLSPQYITGNAYFR 78
Cdd:COG2890    1 MTIRELLRWAAARLAAagVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  79 DLKLAVDKRVLIPRPETEELVDMILAE-NLDAPLNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQ 157
Cdd:COG2890   81 GLEFKVDPGVLIPRPETEELVELALALlPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 158 LD--ITFIESDVFSLIS--GTFDIIVSNPPYISYEDKEEVSLNVLQSEPHLALFAKENGYAIYRKIIEQADNYLTKEGKL 233
Cdd:COG2890  161 LEdrVRFLQGDLFEPLPgdGRFDLIVSNPPYIPEDEIALLPPEVRDHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWL 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 489079861 234 YFEIGYKQAEGIKDMLQAYFpQRHIRVVTDIFGKERMVV 272
Cdd:COG2890  241 LLEIGEDQGEAVRALLEAAG-FADVETHKDLAGRDRVVV 278
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 69-275 1.14e-57

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 186.02  E-value: 1.14e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861   69 QYITGNAYFRDLKLAVDKRVLIPRPETEELVDMILAENLDAP--LNVLDIGTGSGAIAISLKKERPNWQVTASDISRAAL 146
Cdd:TIGR00536  72 AYLLGSKEFYGLEFFVNEHVLIPRPETEELVEKALASLISQPpiLHILDLGTGSGCIALALAYEFPNAEVIAVDISPDAL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  147 DLAKANADAYQL--DITFIESDVFS-LISGTFDIIVSNPPYISYEDKEEVSlNVLQSEPHLALFAKENGYAIYRKIIEQA 223
Cdd:TIGR00536 152 AVAEENAEKNQLehRVEFIQSNLFEpLAGQKIDIIVSNPPYIDEEDLADLP-NVVRFEPLLALVGGDDGLNILRQIIELA 230

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 489079861  224 DNYLTKEGKLYFEIGYKQAEGIKDMLQAYFPQRHIRVVTDIFGKERMVVVDY 275
Cdd:TIGR00536 231 PDYLKPNGFLVCEIGNWQQKSLKELLRIKFTWYDVENGRDLNGKERVVLGFY 282
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 47-255 1.64e-46

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 157.29  E-value: 1.64e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861   47 VTPEDAVLLEHIFCSLSQHLSPQYITGNAYFRDLKLAVDKRVLIPRPETEELVDMILAENLDA--PLNVLDIGTGSGAIA 124
Cdd:TIGR03533  57 TPSEKERILELIERRIEERIPVAYLTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLEPepVKRILDLCTGSGCIA 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  125 ISLKKERPNWQVTASDISRAALDLAKANADAYQLD--ITFIESDVFSLISG-TFDIIVSNPPYISYEDkeevsLNVL--- 198
Cdd:TIGR03533 137 IACAYAFPEAEVDAVDISPDALAVAEINIERHGLEdrVTLIQSDLFAALPGrKYDLIVSNPPYVDAED-----MADLpae 211

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 489079861  199 -QSEPHLALFAKENGYAIYRKIIEQADNYLTKEGKLYFEIGYKQaegikDMLQAYFPQ 255
Cdd:TIGR03533 212 yHHEPELALASGEDGLDLVRRILAEAADHLNENGVLVVEVGNSM-----EALEEAYPD 264
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 12-252 7.21e-41

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 147.70  E-value: 7.21e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  12 DKLEQID------EDRENLAYVFREIKEWssldMLIHQNQAVTPEDAVLLEHIFCSLSQHLSPQYITGNAYFRDLKLAVD 85
Cdd:PRK01544  14 DKLNKIGisspqlEARILLQHVINKPIEY----LLINLDEQLNEAEIEAFEKLLERRLKHEPIAYITGVKEFYSREFIVN 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  86 KRVLIPRPETEELVDMIL-------------------------AENLDAPLNVLDIGTGSGAIAISLKKERPNWQVTASD 140
Cdd:PRK01544  90 KHVLIPRSDTEVLVDVVFqchsresgnpekkqlnpcfrgndisSNCNDKFLNILELGTGSGCIAISLLCELPNANVIATD 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 141 ISRAALDLAKANADAYQLD--ITFIESDVF-SLISGTFDIIVSNPPYISYEDKEEVSLNVLQSEPHLALFAKENGYAIYR 217
Cdd:PRK01544 170 ISLDAIEVAKSNAIKYEVTdrIQIIHSNWFeNIEKQKFDFIVSNPPYISHSEKSEMAIETINYEPSIALFAEEDGLQAYF 249

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 489079861 218 KIIEQADNYLTKEGKLYFEIGYKQAEGIKDMLQAY 252
Cdd:PRK01544 250 IIAENAKQFLKPNGKIILEIGFKQEEAVTQIFLDH 284
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 70-275 1.58e-28

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 112.87  E-value: 1.58e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  70 YITGNAYFRDLKLAVDKRVLIPRPETEELVDMILAEnLDAPLNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLA 149
Cdd:PRK14966 213 YILGVREFYGRRFAVNPNVLIPRPETEHLVEAVLAR-LPENGRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETA 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 150 KANADAYQLDITFIESDVFSL---ISGTFDIIVSNPPYISYEDKeEVSLNVLQSEPHLALFAKENGYAIYRKIIEQADNY 226
Cdd:PRK14966 292 RKNAADLGARVEFAHGSWFDTdmpSEGKWDIIVSNPPYIENGDK-HLLQGDLRFEPQIALTDFSDGLSCIRTLAQGAPDR 370

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 489079861 227 LTKEGKLYFEIGYKQAEGIKDMLqAYFPQRHIRVVTDIFGKERMVVVDY 275
Cdd:PRK14966 371 LAEGGFLLLEHGFDQGAAVRGVL-AENGFSGVETLPDLAGLDRVTLGKY 418
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 102-235 2.43e-27

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 104.50  E-value: 2.43e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 102 ILAENLDAPL--NVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQLD-ITFIESDVFS-LISGTFDI 177
Cdd:COG2813   40 LLLEHLPEPLggRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLEnVEVLWSDGLSgVPDGSFDL 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489079861 178 IVSNPPYisyedkeevslnvlqsepHLALFAkenGYAIYRKIIEQADNYLTKEGKLYF 235
Cdd:COG2813  120 ILSNPPF------------------HAGRAV---DKEVAHALIADAARHLRPGGELWL 156
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 102-242 1.59e-22

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 91.11  E-value: 1.59e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  102 ILAENLDAPL--NVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQLD-ITFIESDVFS-LISGTFDI 177
Cdd:pfam05175  22 LLLEHLPKDLsgKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLEnGEVVASDVYSgVEDGKFDL 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489079861  178 IVSNPPYISyedkeevslnvlqsephlalfAKENGYAIYRKIIEQADNYLTKEGKLYFEI----GYKQA 242
Cdd:pfam05175 102 IISNPPFHA---------------------GLATTYNVAQRFIADAKRHLRPGGELWIVAnrflGYPPL 149
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
107-233 7.93e-20

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 87.69  E-value: 7.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 107 LDAPL--NVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQLDITFIESDVFSLISGTFDIIVSNPPy 184
Cdd:PRK09489 192 LTPHTkgKVLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAANGLEGEVFASNVFSDIKGRFDMIISNPP- 270

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 489079861 185 isYEDKEEVSLNVLQsephlalfakengyaiyrKIIEQADNYLTKEGKL 233
Cdd:PRK09489 271 --FHDGIQTSLDAAQ------------------TLIRGAVRHLNSGGEL 299
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 101-232 5.58e-18

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 79.51  E-value: 5.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  101 MILAENLD--APLNVLDIGTGSGAIAISLKKERPnwQVTASDISRAALDLAKANADAYQLDITFIESDVFSLISGTFDII 178
Cdd:TIGR00537   9 LLLEANLRelKPDDVLEIGAGTGLVAIRLKGKGK--CILTTDINPFAVKELRENAKLNNVGLDVVMTDLFKGVRGKFDVI 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489079861  179 VSNPPYISYEDKEEVSlNVLQsephLALFAKENGYAIYRKIIEQADNYLTKEGK 232
Cdd:TIGR00537  87 LFNPPYLPLEDDLRRG-DWLD----VAIDGGKDGRKVIDRFLDELPEILKEGGR 135
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 113-193 9.41e-17

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 73.75  E-value: 9.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  113 VLDIGTGSGAIAISLKKeRPNWQVTASDISRAALDLAKANADAYQLDITFIESDVFSL--ISGTFDIIVSNPP--YISYE 188
Cdd:pfam13649   1 VLDLGCGTGRLTLALAR-RGGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLpfPDGSFDLVVSSGVlhHLPDP 79


                  ....*
gi 489079861  189 DKEEV 193
Cdd:pfam13649  80 DLEAA 84
PRK14968 PRK14968
putative methyltransferase; Provisional
 102-235 1.51e-16

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 75.71  E-value: 1.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 102 ILAENLDAPLN--VLDIGTGSGAIAISLKKErpNWQVTASDISRAALDLAKANA---DAYQLDITFIESDVFSLISG-TF 175
Cdd:PRK14968  14 LLAENAVDKKGdrVLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAklnNIRNNGVEVIRSDLFEPFRGdKF 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489079861 176 DIIVSNPPYISYEDKEEVS--LNvlqsephLALFAKENGYAIYRKIIEQADNYLTKEGKLYF 235
Cdd:PRK14968  92 DVILFNPPYLPTEEEEEWDdwLN-------YALSGGKDGREVIDRFLDEVGRYLKPGGRILL 146
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 96-181 2.63e-15

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 70.82  E-value: 2.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  96 EELVDMILAENLDAPLNVLDIGTGSGAIAISLKKErpNWQVTASDISRAALDLAKANADayQLDITFIESDV--FSLISG 173
Cdd:COG2227   11 DRRLAALLARLLPAGGRVLDVGCGTGRLALALARR--GADVTGVDISPEALEIARERAA--ELNVDFVQGDLedLPLEDG 86


                 ....*...
gi 489079861 174 TFDIIVSN 181
Cdd:COG2227   87 SFDLVICS 94
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 106-273 9.29e-15

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 71.71  E-value: 9.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 106 NLDAPLNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQLD--ITFIESDV----FSLISGTFDIIV 179
Cdd:COG4123   34 PVKKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEdrITVIHGDLkefaAELPPGSFDLVV 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 180 SNPPYisYEDKE-EVSLNvlqsePHLALfAKENGYAIYRKIIEQADNYLTKEGKLYFEIGYKQAEGIKDMLQAY--FPQR 256
Cdd:COG4123  114 SNPPY--FKAGSgRKSPD-----EARAI-ARHEDALTLEDLIRAAARLLKPGGRFALIHPAERLAEILAALRKYglGPKR 185

                        170
                 ....*....|....*...
gi 489079861 257 hIRVVTDIFGKE-RMVVV 273
Cdd:COG4123  186 -LRPVHPRPGKPaKRVLL 202
PRK14967 PRK14967
putative methyltransferase; Provisional
 91-185 6.31e-14

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 69.31  E-value: 6.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  91 PRPETEELVDMILAENLDAPLNVLDIGTGSGAIAISLKKERPNWqVTASDISRAALDLAKANADAYQLDITFIESD-VFS 169
Cdd:PRK14967  18 PQEDTQLLADALAAEGLGPGRRVLDLCTGSGALAVAAAAAGAGS-VTAVDISRRAVRSARLNALLAGVDVDVRRGDwARA 96

                         90
                 ....*....|....*.
gi 489079861 170 LISGTFDIIVSNPPYI 185
Cdd:PRK14967  97 VEFRPFDVVVSNPPYV 112
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
109-181 1.02e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 65.62  E-value: 1.02e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489079861 109 APLNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADayqlDITFIESDVFSL-ISGTFDIIVSN 181
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLP----NVRFVVADLRDLdPPEPFDLVVSN 70
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 112-189 3.30e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 64.37  E-value: 3.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 112 NVLDIGTGSGAIAISLkKERPNWQVTASDISRAALDLAKANADAYQLD-ITFIESDVFSLIS---GTFDIIVSNPPYISY 187
Cdd:cd02440    1 RVLDLGCGTGALALAL-ASGPGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEELPPeadESFDVIISDPPLHHL 79


                 ..
gi 489079861 188 ED 189
Cdd:cd02440   80 VE 81
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 96-251 6.05e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 64.63  E-value: 6.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  96 EELVDMIlaeNLDAPLNVLDIGTGSGAIAISLKkeRPNWQVTASDISRAALDLAKANADAYQLDITFIESDVFSL--ISG 173
Cdd:COG2226   12 EALLAAL---GLRPGARVLDLGCGTGRLALALA--ERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLpfPDG 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489079861 174 TFDIIVSNppyisyedkeevslNVLQSEPHLALFAKEngyaIYRkiieqadnYLTKEGKLYF-EIGYKQAEGIKDMLQA 251
Cdd:COG2226   87 SFDLVISS--------------FVLHHLPDPERALAE----IAR--------VLKPGGRLVVvDFSPPDLAELEELLAE 139
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 90-181 6.45e-12

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 63.01  E-value: 6.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  90 IPRPETEELVDMIlaENLDAPLNVLDIGTGSGAIAISLKkERPNWQVTASDISRAALDLAKANADAYQLD-ITFIESDVF 168
Cdd:COG0500    9 ELLPGLAALLALL--ERLPKGGRVLDLGCGTGRNLLALA-ARFGGRVIGIDLSPEAIALARARAAKAGLGnVEFLVADLA 85

                         90
                 ....*....|....*.
gi 489079861 169 S---LISGTFDIIVSN 181
Cdd:COG0500   86 EldpLPAESFDLVVAF 101
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 114-181 2.46e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 58.92  E-value: 2.46e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489079861  114 LDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQLD----ITFIESDVFSLISGTFDIIVSN 181
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLnavrVELFQLDLGELDPGSFDVVVAS 72
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
113-183 7.80e-11

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 59.92  E-value: 7.80e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489079861 113 VLDIGTGSGAIAISLKKERPNwQVTASDISRAALDLAKANADAYQLDITFIESDVFSL-ISGTFDIIVSNPP 183
Cdd:COG2263   49 VLDLGCGTGMLAIGAALLGAK-KVVGVDIDPEALEIARENAERLGVRVDFIRADVTRIpLGGSVDTVVMNPP 119
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 113-180 6.03e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 56.86  E-value: 6.03e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489079861 113 VLDIGTGSGAIAISLKKERpNWQVTASDISRAALDLAKANADAYQLD--ITFIESDVFSL-ISGTFDIIVS 180
Cdd:COG2230   55 VLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLAdrVEVRLADYRDLpADGQFDAIVS 124
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
103-215 8.42e-10

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 58.26  E-value: 8.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 103 LAENLDAPLNVLDIGTGSG--AIAISLKKERPnwqVTASDISRAALDLAKANADAYQLD--ITFIESDVFSliSGTFDII 178
Cdd:COG2264  142 LEKLLKPGKTVLDVGCGSGilAIAAAKLGAKR---VLAVDIDPVAVEAARENAELNGVEdrIEVVLGDLLE--DGPYDLV 216

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489079861 179 VSNppyIsyedkeevsL-NVLQSE-PHLALFAKENGYAI 215
Cdd:COG2264  217 VAN---I---------LaNPLIELaPDLAALLKPGGYLI 243
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 113-179 7.23e-09

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 54.51  E-value: 7.23e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489079861 113 VLDIGTGSGAIAISLKKeRPNWQVTASDISRAALDLAKANADAYQLDITFIESDVFSL-ISGTFDIIV 179
Cdd:COG3897   74 VLELGCGLGLVGIAAAK-AGAADVTATDYDPEALAALRLNAALNGVAITTRLGDWRDPpAAGGFDLIL 140
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 107-181 2.52e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 52.03  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  107 LDAPLNVLDIGTGSGAIAISL-KKERPNWQVTASDISRAALDLAKANADAYQLD-ITFIESDVFSLIS----GTFDIIVS 180
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELaEELGPNAEVVGIDISEEAIEKARENAQKLGFDnVEFEQGDIEELPElledDKFDVVIS 80


                  .
gi 489079861  181 N 181
Cdd:pfam13847  81 N 81
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 114-181 3.15e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 50.36  E-value: 3.15e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  114 LDIGTGSGAIAISLKKERPnwQVTASDISRAALDLAKANADayQLDITFIESDVFSL--ISGTFDIIVSN 181
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA--RVTGVDISPEMLELAREKAP--REGLTFVVGDAEDLpfPDNSFDLVLSS 66
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
96-259 1.53e-07

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 50.38  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  96 EELVDMILAENLDAP-LNVLDIGTGSGAIAISLKKERpnWQVTASDISRAALDLAKANAdayqLDITFIESDVFSL--IS 172
Cdd:COG4976   32 ALLAEELLARLPPGPfGRVLDLGCGTGLLGEALRPRG--YRLTGVDLSEEMLAKAREKG----VYDRLLVADLADLaePD 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 173 GTFDIIVSNppyisyedkeevslNVLQSEPHLalfakengyaiyRKIIEQADNYLTKEGKLYFEIGYKQAEGikdmlQAY 252
Cdd:COG4976  106 GRFDLIVAA--------------DVLTYLGDL------------AAVFAGVARALKPGGLFIFSVEDADGSG-----RYA 154


                 ....*..
gi 489079861 253 FPQRHIR 259
Cdd:COG4976  155 HSLDYVR 161
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 119-193 2.22e-07

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 50.05  E-value: 2.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  119 GSGAIAI-----------SLKKERPNWQVTASDISRAALDLAKANADAYQLD--ITFIESDV--FSLISGTFDIIVSNPP 183
Cdd:pfam01170  38 GSGTILIeaalmganiapGKFDARVRAPLYGSDIDRRMVQGARLNAENAGVGdlIEFVQADAadLPLLEGSVDVIVTNPP 117

                          90
                  ....*....|.
gi 489079861  184 Y-ISYEDKEEV 193
Cdd:pfam01170 118 YgIRLGSKGAL 128
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 135-235 3.44e-07

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 50.95  E-value: 3.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 135 QVTASDISRAALDLAKANADAYQLD--ITFIESDVFSLI------SGTFDIIVSNPPyisyedkeevslnvlqsephlAl 206
Cdd:COG1092  241 SVTSVDLSATALEWAKENAALNGLDdrHEFVQADAFDWLrelareGERFDLIILDPP---------------------A- 298

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489079861 207 FAK-----ENGYAIYRKIIEQADNYLTKEGKLYF 235
Cdd:COG1092  299 FAKskkdlFDAQRDYKDLNRLALKLLAPGGILVT 332
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
111-235 8.37e-07

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 49.56  E-value: 8.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 111 LNVLDIGTGSG----AIAISLKKERpnwQVTASDISRAALDLAKANADAYQLDITFIESDVFS-LISGTFDIIVSNPPYI 185
Cdd:COG0827  117 LRILDPAVGTGnlltTVLNQLKKKV---NAYGVEVDDLLIRLAAVLANLQGHPVELFHQDALQpLLIDPVDVVISDLPVG 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 489079861 186 SYEDKEevslnvlQSEPHLALFAKENGYAIYRkIIEQADNYLTKEGKLYF 235
Cdd:COG0827  194 YYPNDE-------RAKRFKLKADEGHSYAHHL-FIEQSLNYLKPGGYLFF 235
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 124-184 9.73e-07

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 49.33  E-value: 9.73e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489079861 124 AISLKKERPNWQVTASDISRAALDLAKANADAYQLD--ITFIESDVFSL-ISGTFDIIVSNPPY 184
Cdd:COG0116  241 AEARIKRDPPLPIFGSDIDPRAIEAARENAERAGVAdlIEFEQADFRDLePPAEPGLIITNPPY 304
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 103-181 9.74e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 47.81  E-value: 9.74e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489079861  103 LAENLDAPLNVLDIGTGSGAIAISLKKERpnWQVTASDISRAALDLAKANADAYQLDITFIESDvfsliSGTFDIIVSN 181
Cdd:pfam13489  16 LLPKLPSPGRVLDFGCGTGIFLRLLRAQG--FSVTGVDPSPIAIERALLNVRFDQFDEQEAAVP-----AGKFDVIVAR 87
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 113-167 1.69e-06

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 46.17  E-value: 1.69e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489079861  113 VLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQL-DITFIESDV 167
Cdd:TIGR02469  23 LWDIGAGTGSVTIEAARLVPNGRVYAIERNPEALDLIERNLRRFGVsNIVIVEGDA 78
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
103-181 4.51e-06

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 46.68  E-value: 4.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 103 LAENLDAPLNVLDIGTGSG--AIAISLKKerpNWQVTASDISRAALDLAKANADAYQ--LDITFIESDvfslisGTFDII 178
Cdd:PRK00517 113 LEKLVLPGKTVLDVGCGSGilAIAAAKLG---AKKVLAVDIDPQAVEAARENAELNGveLNVYLPQGD------LKADVI 183


                 ...
gi 489079861 179 VSN 181
Cdd:PRK00517 184 VAN 186
PRK06202 PRK06202
hypothetical protein; Provisional
 108-181 6.07e-06

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 46.15  E-value: 6.07e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489079861 108 DAPLNVLDIGTGSGAIAISL----KKERPNWQVTASDISRAALDLAKANADAYQLDITFIESDVFSLISGTFDIIVSN 181
Cdd:PRK06202  59 DRPLTLLDIGCGGGDLAIDLarwaRRDGLRLEVTAIDPDPRAVAFARANPRRPGVTFRQAVSDELVAEGERFDVVTSN 136
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 112-178 6.27e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 46.30  E-value: 6.27e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489079861 112 NVLDIGTGSGAIAISLKKE-RPNWQVTASDISRAALDLA--KANADAYQLDITFIESDVFSL--ISGTFDII 178
Cdd:PRK00216  54 KVLDLACGTGDLAIALAKAvGKTGEVVGLDFSEGMLAVGreKLRDLGLSGNVEFVQGDAEALpfPDNSFDAV 125
PRK15128 PRK15128
23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;
135-183 7.49e-06

23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;


Pssm-ID: 185082 [Multi-domain]  Cd Length: 396  Bit Score: 46.75  E-value: 7.49e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489079861 135 QVTASDISRAALDLAKANADAYQLDIT---FIESDVFSLISG------TFDIIVSNPP 183
Cdd:PRK15128 245 QVVSVDTSQEALDIARQNVELNKLDLSkaeFVRDDVFKLLRTyrdrgeKFDVIVMDPP 302
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 113-164 3.07e-05

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 44.77  E-value: 3.07e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489079861 113 VLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADAYQL-DITFIE 164
Cdd:COG2242  251 LWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGVpNVEVVE 303
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 97-181 3.56e-05

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 44.20  E-value: 3.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861   97 ELVDMILAENLDAPLNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKanaDAYQLDITFIESDV--FSLISGT 174
Cdd:TIGR02072  22 RLLALLKEKGIFIPASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAK---TKLSENVQFICGDAekLPLEDSS 98


                  ....*..
gi 489079861  175 FDIIVSN 181
Cdd:TIGR02072  99 FDLIVSN 105
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 112-225 5.80e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 43.79  E-value: 5.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  112 NVLDIGTGSG--AIAISL---KKerpnwqVTASDISRAALDLAKANADAYQLDITFIESDVFSLISGTFDIIVSNppyis 186
Cdd:pfam06325 164 SVLDVGCGSGilAIAALKlgaKK------VVGVDIDPVAVRAAKENAELNGVEARLEVYLPGDLPKEKADVVVAN----- 232

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 489079861  187 yedkeeVSLNVLQS-EPHLALFAKENGYAIYRKII-EQADN 225
Cdd:pfam06325 233 ------ILADPLIElAPDIYALVKPGGYLILSGILkEQAQM 267
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 96-179 1.30e-04

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 42.13  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  96 EELVDMILAENLDAPLNVLDIGTGSGAIAISLKKErpNWQVTASDISRAALDLAK--ANADAYQLDITFIESDVFSLiSG 173
Cdd:PRK07580  50 DTVLSWLPADGDLTGLRILDAGCGVGSLSIPLARR--GAKVVASDISPQMVEEARerAPEAGLAGNITFEVGDLESL-LG 126


                 ....*.
gi 489079861 174 TFDIIV 179
Cdd:PRK07580 127 RFDTVV 132
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
100-167 2.43e-04

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 41.49  E-value: 2.43e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 100 DMILAENLDAPLNVLDIGTGSGAIAISLKKErpNWQVTASDISRAALDLAKANADAYQL--DITFIESDV 167
Cdd:PRK11036  35 DRLLAELPPRPLRVLDAGGGEGQTAIKLAEL--GHQVILCDLSAEMIQRAKQAAEAKGVsdNMQFIHCAA 102
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 102-184 4.28e-04

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 40.06  E-value: 4.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 102 ILAENLDApLNVLDIGTGSGAIAI-------SlkkerpnwQVTASDISRAALDLAKANADAYQLD--ITFIESDVFSLI- 171
Cdd:COG0742   35 ILGPDIEG-ARVLDLFAGSGALGLealsrgaA--------SVVFVEKDRKAAAVIRKNLEKLGLEdrARVIRGDALRFLk 105

                         90
                 ....*....|....*.
gi 489079861 172 ---SGTFDIIVSNPPY 184
Cdd:COG0742  106 rlaGEPFDLVFLDPPY 121
CheR pfam01739
CheR methyltransferase, SAM binding domain; CheR proteins are part of the chemotaxis signaling ...
 96-151 7.87e-04

CheR methyltransferase, SAM binding domain; CheR proteins are part of the chemotaxis signaling mechanism in bacteria. CheR methylates the chemotaxis receptor at specific glutamate residues. CheR is an S-adenosylmethionine- dependent methyltransferase - the C-terminal domain (this one) binds SAM.


Pssm-ID: 426403  Cd Length: 190  Bit Score: 39.57  E-value: 7.87e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489079861   96 EELVDMILAE----NLDAPLNVLDIGTGSG----AIAISLKKERPN-----WQVTASDISRAALDLAKA 151
Cdd:pfam01739  13 EELKKYVLPLlakaKNGKRVRIWSAGCSSGeepySLAMLLKETFPNaarwdFKILATDIDLSVLEKARA 81
met_A_Alw26 TIGR02987
type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Members of ...
 76-229 8.60e-04

type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Members of this family are the m6-adenine DNA methyltransferase protein, or domain of a fusion protein that also carries m5 cytosine methyltransferase activity, of type II restriction systems of the Alw26I/Eco31I/Esp3I family. A methyltransferase of this family is alway accompanied by a type II restriction endonuclease from the Alw26I/Eco31I/Esp3I family (TIGR02986) and by an adenine-specific modification methyltransferase. Members of this family are unusual in that regions of similarity to homologs outside this family are circularly permuted. [DNA metabolism, Restriction/modification]


Pssm-ID: 274377 [Multi-domain]  Cd Length: 524  Bit Score: 40.52  E-value: 8.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861   76 YFRDLKLAvdkRVLIprpetEELVDMILAENLDAPLNVLDIGTGSGA-IAISLKK-----ERPN--WQVTASDISRAALD 147
Cdd:TIGR02987   6 FFTPPDIA---KAMV-----ANLVNEIGKNDKSTKTKIIDPCCGDGRlIAALLKKneeinYFKEveLNIYFADIDKTLLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  148 LAKAN-ADAYQLDITFI----ESDVFSLI---SGTFDIIVSNPPY--ISYEDKEEVSLNVLQSEphlalfakengyaIYR 217
Cdd:TIGR02987  78 RAKKLlGEFALLEINVInfnsLSYVLLNIesyLDLFDIVITNPPYgrLKPDKKELTNIETLEYE-------------KYI 144

                         170
                  ....*....|..
gi 489079861  218 KIIEQADNYLTK 229
Cdd:TIGR02987 145 DFLKEFDDLLSR 156
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 110-204 8.85e-04

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 39.24  E-value: 8.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  110 PLNVLDIGTGSGAIAISLKKERPNWQVTASDISRaALDLAKAN--ADAYQLDITF--------IESDVFSLisGTFD-II 178
Cdd:pfam10294  47 GLNVLELGSGTGLVGIAVALLLPGASVTITDLEE-ALELLKKNieLNALSSKVVVkvldwgenLPPDLFDG--HPVDlIL 123

                          90       100
                  ....*....|....*....|....*...
gi 489079861  179 VSNPPYI--SYEDKEEVSLNVLQSEPHL 204
Cdd:pfam10294 124 AADCVYNedSFPLLEKTLKDLLGKESVI 151
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
113-180 1.00e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 39.63  E-value: 1.00e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489079861 113 VLDIGTGSGAIAISLKKERPNwQVTASDISRAALDLAKANADAYQLD--ITFIESDVFSL-ISGTFDIIVS 180
Cdd:COG4076   39 VLDIGTGSGLLSMLAARAGAK-KVYAVEVNPDIAAVARRIIAANGLSdrITVINADATDLdLPEKADVIIS 108
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
93-152 1.39e-03

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 38.83  E-value: 1.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489079861  93 PETEELVDMILAE--NLDAPLNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKAN 152
Cdd:PRK08287  13 PMTKEEVRALALSklELHRAKHLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKEN 74
PRK08317 PRK08317
hypothetical protein; Provisional
 113-180 1.74e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 38.76  E-value: 1.74e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489079861 113 VLDIGTGSGAIAISLKKE-RPNWQVTASDISRAALDLAKANADAYQLDITFIESDVFSL--ISGTFDIIVS 180
Cdd:PRK08317  23 VLDVGCGPGNDARELARRvGPEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGLpfPDGSFDAVRS 93
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 6-73 2.11e-03

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 35.92  E-value: 2.11e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861    6 LIRTYEDKLEQ--IDEDRENLAYVFREIKEWSSLDMLIHQNQAVTPEDAVLLEHIFCSLSQHLSPQYITG 73
Cdd:pfam17827   2 ALRWASSRLKEagIESPRLDAELLLAHVLGLDRTDLLLHPEEELSEEELERFEELLERRAAGEPLQYILG 71
PRK12335 PRK12335
tellurite resistance protein TehB; Provisional
 100-180 2.12e-03

tellurite resistance protein TehB; Provisional


Pssm-ID: 183450 [Multi-domain]  Cd Length: 287  Bit Score: 38.77  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 100 DMILAENLDAPLNVLDIGTGSGAIAISLKKErpNWQVTASDISRAALDLAKANADAYQLDITFIESDVFS-LISGTFDII 178
Cdd:PRK12335 111 EVLEAVQTVKPGKALDLGCGQGRNSLYLALL--GFDVTAVDINQQSLENLQEIAEKENLNIRTGLYDINSaSIQEEYDFI 188


                 ..
gi 489079861 179 VS 180
Cdd:PRK12335 189 LS 190
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 110-178 3.17e-03

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 37.47  E-value: 3.17e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489079861 110 PLNVLDIGTGSG--AIAIsLKKERPNWQVTASDISRAALDLAKANADAYQLD--ITFIESDVF----SLISGTFDII 178
Cdd:COG4122   17 AKRILEIGTGTGysTLWL-ARALPDDGRLTTIEIDPERAAIARENFARAGLAdrIRLILGDALevlpRLADGPFDLV 92
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 138-184 6.22e-03

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 37.86  E-value: 6.22e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489079861 138 ASDISRAALDLAKANADAYQLD--ITFIESDVFSLISGTFD----IIVSNPPY 184
Cdd:PRK11783 261 GSDIDPRVIQAARKNARRAGVAelITFEVKDVADLKNPLPKgptgLVISNPPY 313
PRK11727 PRK11727
23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF;
79-184 7.89e-03

23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF;


Pssm-ID: 236964  Cd Length: 321  Bit Score: 37.15  E-value: 7.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861  79 DLkLAVDKRVLIPRPeteelvdmilaenldAPLNVLDIGTGSGAIAISLKKERPNWQVTASDISRAALDLAKANADA--- 155
Cdd:PRK11727 100 DL-LAEDNGGVIPRG---------------ANVRVLDIGVGANCIYPLIGVHEYGWRFVGSDIDPQALASAQAIISAnpg 163

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 489079861 156 --------YQLDitfiESDVFSLISGT---FDIIVSNPPY 184
Cdd:PRK11727 164 lngairlrLQKD----SKAIFKGIIHKnerFDATLCNPPF 199
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
112-186 9.13e-03

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 36.81  E-value: 9.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079861 112 NVLDIGTGSGAIAI-SLKkeRPNWQVTASDISRAALDLAKANADAYQLD---ITFIESDVFSLI----SGTFDIIVSNPP 183
Cdd:COG2521  135 RVLDTCTGLGYTAIeALK--RGAREVITVEKDPNVLELAELNPWSRELAnerIKIILGDASEVIktfpDESFDAIIHDPP 212


                 ...
gi 489079861 184 YIS 186
Cdd:COG2521  213 RFS 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH