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Conserved domains on  [gi|489079865|ref|WP_002989802|]
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thymidine kinase [Streptococcus pyogenes]

Protein Classification

thymidine kinase( domain architecture ID 10012185)

thymidine kinase catalyzes the phosphorylation of both thymidine and deoxyuridine

EC:  2.7.1.21
Gene Ontology:  GO:0004797|GO:0005524|GO:0008270
SCOP:  4003437

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PRK04296 PRK04296
thymidine kinase; Provisional
1-187 1.18e-112

thymidine kinase; Provisional


:

Pssm-ID: 235272  Cd Length: 190  Bit Score: 318.60  E-value: 1.18e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865   1 MAQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTRDGFGIVSSRIGMRREAIPISNDMDIFTFIAQLEEKPY 80
Cdd:PRK04296   1 MAKLEFIYGAMNSGKSTELLQRAYNYEERGMKVLVFKPAIDDRYGEGKVVSRIGLSREAIPVSSDTDIFELIEEEGEKID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865  81 CVLIDESQFLSKQNVYDLARVVDELNVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKATMVLRT-ENG 159
Cdd:PRK04296  81 CVLIDEAQFLDKEQVVQLAEVLDDLGIPVICYGLDTDFRGEPFEGSPYLLALADKVTELKAICVHCGRKATMNQRLiDGG 160
                        170       180
                 ....*....|....*....|....*...
gi 489079865 160 KPVYEGDQIQIGGNETYIPVCRKHYFNP 187
Cdd:PRK04296 161 PAVYEGPQVLVGGNESYEAVCRKHYKEA 188
 
Name Accession Description Interval E-value
PRK04296 PRK04296
thymidine kinase; Provisional
1-187 1.18e-112

thymidine kinase; Provisional


Pssm-ID: 235272  Cd Length: 190  Bit Score: 318.60  E-value: 1.18e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865   1 MAQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTRDGFGIVSSRIGMRREAIPISNDMDIFTFIAQLEEKPY 80
Cdd:PRK04296   1 MAKLEFIYGAMNSGKSTELLQRAYNYEERGMKVLVFKPAIDDRYGEGKVVSRIGLSREAIPVSSDTDIFELIEEEGEKID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865  81 CVLIDESQFLSKQNVYDLARVVDELNVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKATMVLRT-ENG 159
Cdd:PRK04296  81 CVLIDEAQFLDKEQVVQLAEVLDDLGIPVICYGLDTDFRGEPFEGSPYLLALADKVTELKAICVHCGRKATMNQRLiDGG 160
                        170       180
                 ....*....|....*....|....*...
gi 489079865 160 KPVYEGDQIQIGGNETYIPVCRKHYFNP 187
Cdd:PRK04296 161 PAVYEGPQVLVGGNESYEAVCRKHYKEA 188
Tdk COG1435
Thymidine kinase [Nucleotide transport and metabolism]; Thymidine kinase is part of the ...
1-187 6.98e-104

Thymidine kinase [Nucleotide transport and metabolism]; Thymidine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441044  Cd Length: 192  Bit Score: 296.63  E-value: 6.98e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865   1 MAQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTRDGFGIVSSRIGMRREAIPISNDMDIFTFIAQlEEKPY 80
Cdd:COG1435    3 MGKLEFIYGPMFSGKSEELLRRAHNYEEAGQKVLLFKPAIDDRYGEGKIVSRIGLSREAIPVDDDTDILELVRE-GPDVD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865  81 CVLIDESQFLSKQNVYDLARVVDELNVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKATMVLRT-ENG 159
Cdd:COG1435   82 VVLIDEAQFLDPEQVDQLARLADRLGIPVICAGLDTDFRGEPFPGSPRLLALADEVTKLKAICVVCGRKATMNQRLvDGG 161
                        170       180
                 ....*....|....*....|....*...
gi 489079865 160 KPVYEGDQIQIGGNETYIPVCRKHYFNP 187
Cdd:COG1435  162 PAVYEGEQVLIGGNESYEARCRRHYREP 189
TK pfam00265
Thymidine kinase;
2-184 1.49e-54

Thymidine kinase;


Pssm-ID: 306721  Cd Length: 176  Bit Score: 170.98  E-value: 1.49e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865    2 AQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTRDGFGIVSSRIGMRREAIPIsnDMDIFTFIAQ--LEEKP 79
Cdd:pfam00265   1 GSIHLIYGPMFSGKSTELIRRVYRYQEAGMKCVVIKYAIDNRYGTGKVVTHDGISMEAKQC--KTSSLDDIKDhlSQTDI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865   80 YCVLIDESQFLSkqNVYDLARVVDELNVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKATMVLRTENg 159
Cdd:pfam00265  79 HVVGVDEAQFFD--DIVEFCESMANLGKPVIVAGLDGDFQRKLFGNILNLLPLAEKVTKLKAICMKCGKDASFTKRLNN- 155
                         170       180
                  ....*....|....*....|....*
gi 489079865  160 kpvyEGDQIQIGGNETYIPVCRKHY 184
Cdd:pfam00265 156 ----EKEIILIGGNEKYVSVCRKCY 176
FtsY cd17874
signal recognition particle receptor FtsY; FtsY, the bacterial signal-recognition particle ...
9-42 7.32e-03

signal recognition particle receptor FtsY; FtsY, the bacterial signal-recognition particle (SRP) receptor (SR), is homologous to the SRP receptor alpha-subunit (SRalpha) of the eukaryotic SR. It interacts with the signal-recognition particle (SRP) and is required for the co-translational membrane targeting of proteins.


Pssm-ID: 349783  Cd Length: 199  Bit Score: 36.01  E-value: 7.32e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 489079865   9 GTMNSGKTIEILKVAHNYEEQGKPVVImtSALDT 42
Cdd:cd17874    7 GVNGVGKTTTIGKLAHYLKNQGKKVVL--AAGDT 38
 
Name Accession Description Interval E-value
PRK04296 PRK04296
thymidine kinase; Provisional
1-187 1.18e-112

thymidine kinase; Provisional


Pssm-ID: 235272  Cd Length: 190  Bit Score: 318.60  E-value: 1.18e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865   1 MAQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTRDGFGIVSSRIGMRREAIPISNDMDIFTFIAQLEEKPY 80
Cdd:PRK04296   1 MAKLEFIYGAMNSGKSTELLQRAYNYEERGMKVLVFKPAIDDRYGEGKVVSRIGLSREAIPVSSDTDIFELIEEEGEKID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865  81 CVLIDESQFLSKQNVYDLARVVDELNVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKATMVLRT-ENG 159
Cdd:PRK04296  81 CVLIDEAQFLDKEQVVQLAEVLDDLGIPVICYGLDTDFRGEPFEGSPYLLALADKVTELKAICVHCGRKATMNQRLiDGG 160
                        170       180
                 ....*....|....*....|....*...
gi 489079865 160 KPVYEGDQIQIGGNETYIPVCRKHYFNP 187
Cdd:PRK04296 161 PAVYEGPQVLVGGNESYEAVCRKHYKEA 188
Tdk COG1435
Thymidine kinase [Nucleotide transport and metabolism]; Thymidine kinase is part of the ...
1-187 6.98e-104

Thymidine kinase [Nucleotide transport and metabolism]; Thymidine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441044  Cd Length: 192  Bit Score: 296.63  E-value: 6.98e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865   1 MAQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTRDGFGIVSSRIGMRREAIPISNDMDIFTFIAQlEEKPY 80
Cdd:COG1435    3 MGKLEFIYGPMFSGKSEELLRRAHNYEEAGQKVLLFKPAIDDRYGEGKIVSRIGLSREAIPVDDDTDILELVRE-GPDVD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865  81 CVLIDESQFLSKQNVYDLARVVDELNVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKATMVLRT-ENG 159
Cdd:COG1435   82 VVLIDEAQFLDPEQVDQLARLADRLGIPVICAGLDTDFRGEPFPGSPRLLALADEVTKLKAICVVCGRKATMNQRLvDGG 161
                        170       180
                 ....*....|....*....|....*...
gi 489079865 160 KPVYEGDQIQIGGNETYIPVCRKHYFNP 187
Cdd:COG1435  162 PAVYEGEQVLIGGNESYEARCRRHYREP 189
TK pfam00265
Thymidine kinase;
2-184 1.49e-54

Thymidine kinase;


Pssm-ID: 306721  Cd Length: 176  Bit Score: 170.98  E-value: 1.49e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865    2 AQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTRDGFGIVSSRIGMRREAIPIsnDMDIFTFIAQ--LEEKP 79
Cdd:pfam00265   1 GSIHLIYGPMFSGKSTELIRRVYRYQEAGMKCVVIKYAIDNRYGTGKVVTHDGISMEAKQC--KTSSLDDIKDhlSQTDI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865   80 YCVLIDESQFLSkqNVYDLARVVDELNVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKATMVLRTENg 159
Cdd:pfam00265  79 HVVGVDEAQFFD--DIVEFCESMANLGKPVIVAGLDGDFQRKLFGNILNLLPLAEKVTKLKAICMKCGKDASFTKRLNN- 155
                         170       180
                  ....*....|....*....|....*
gi 489079865  160 kpvyEGDQIQIGGNETYIPVCRKHY 184
Cdd:pfam00265 156 ----EKEIILIGGNEKYVSVCRKCY 176
PTZ00293 PTZ00293
thymidine kinase; Provisional
8-184 8.09e-16

thymidine kinase; Provisional


Pssm-ID: 185542  Cd Length: 211  Bit Score: 72.06  E-value: 8.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865   8 YGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTR--DGFGIVSSRIGMRReAIPISNDMDIFTfiaqlEEKPYCVL-I 84
Cdd:PTZ00293  10 IGPMFSGKTTELMRLVKRFTYSEKKCVVIKYSKDTRysDEQNISSHDKQMLK-AIKVSKLKEVLE-----TAKNYDVIaI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079865  85 DESQFLSkqNVYDLARVVDELNVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKATMVLRTengkpVYE 164
Cdd:PTZ00293  84 DEGQFFP--DLVEFSEAAANLGKIVIVAALDGTFQRKPFGQILNLIPLAERVTKLTAVCMFCGKEASFSKRI-----VQS 156
                        170       180
                 ....*....|....*....|
gi 489079865 165 GDQIQIGGNETYIPVCRKHY 184
Cdd:PTZ00293 157 EQIELIGGEDKYIATCRKCF 176
FtsY cd17874
signal recognition particle receptor FtsY; FtsY, the bacterial signal-recognition particle ...
9-42 7.32e-03

signal recognition particle receptor FtsY; FtsY, the bacterial signal-recognition particle (SRP) receptor (SR), is homologous to the SRP receptor alpha-subunit (SRalpha) of the eukaryotic SR. It interacts with the signal-recognition particle (SRP) and is required for the co-translational membrane targeting of proteins.


Pssm-ID: 349783  Cd Length: 199  Bit Score: 36.01  E-value: 7.32e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 489079865   9 GTMNSGKTIEILKVAHNYEEQGKPVVImtSALDT 42
Cdd:cd17874    7 GVNGVGKTTTIGKLAHYLKNQGKKVVL--AAGDT 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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