|
Name |
Accession |
Description |
Interval |
E-value |
| PBP2_ChoS |
cd13610 |
Substrate-binding domain ChoS of an osmoregulated ABC-type transporter and related proteins; ... |
238-500 |
1.03e-157 |
|
Substrate-binding domain ChoS of an osmoregulated ABC-type transporter and related proteins; type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein ChoS of Lactococcus lactis is predicted to be involved in uptake of compatible solutes such as choline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. ChoS belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270328 Cd Length: 264 Bit Score: 448.58 E-value: 1.03e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 238 TVVIAGKLGAEPDILINLYKELIEDQS-DISVELKSNFGKTSFLYEALKSGDIDMYPEFTGTITSSLLRDkPPLSNDPKQ 316
Cdd:cd13610 1 SIVIAGKLGSEPDILINMYKLLIEEETpDLQVTLKPNFGKTSFLFNALKSGDIDIYPEFTGTVLETLLKE-PPKSNDPME 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 317 VYEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQSQYGLQL 396
Cdd:cd13610 80 VYEQARDGLAKQYQLTYLKPMAYNNTYALAVKKEFAKQHNLKTISDLQKVQDKLKAGFTLEFMDREDGYKGLQKAYGLNF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 397 SVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTKHPELKGILNQLAGKITEK 476
Cdd:cd13610 160 NVKSMEPALRYQAINNGQVNVIDAYSTDSEIKQYDLVVLKDDKHLFPPYQGAPLMREEFLKKHPELVKALNKLAGKITDE 239
|
250 260
....*....|....*....|....
gi 489079873 477 EMQDMNYEVSVKGADANKVARDYL 500
Cdd:cd13610 240 EMQEMNYRVDVKHKSAAKVAKEYL 263
|
|
| OsmF |
COG1732 |
Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system ... |
207-500 |
2.49e-125 |
|
Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441338 [Multi-domain] Cd Length: 294 Bit Score: 367.55 E-value: 2.49e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 207 RRIMISFGITLLALLASYtpmALSQFSKGKDTVVIAGKLGAEPDILINLYKELIEDQsDISVELKSNFGKTSFLYEALKS 286
Cdd:COG1732 3 RLLLLALALAAALALAGC---GLASAAAAGDTIVVGSKNFTEQEILAEIYAQALEAA-GLKVERKLNLGGTEVVRQALKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 287 GDIDMYPEFTGTITSSLLRDKPplSNDPKQVYEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAH 366
Cdd:COG1732 79 GEIDLYPEYTGTALTTYLKEDP--ITDPEEVYEAVKEALPEKNGLTWLDPAGFNNTYALAVTKETAEKYGLKTISDLAKV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 367 ADTLKAGFTLEFKDRADGYKGMQSQYGLQL-SVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPY 445
Cdd:COG1732 157 AGELTLGADPEFAERPDGLPGLKKAYGFEFkEVKPMDTGLTYTALANGQVDVADAYTTDGRIAALDLVVLEDDKNFFPPY 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 489079873 446 QGAPLMKTSLLTKHPELKGILNQLAGKITEKEMQDMNYEVSVKGADANKVARDYL 500
Cdd:COG1732 237 NAAPLVRKEVLEKYPELAEVLNKLSGKLTTETMQELNYQVDVDGEDPADVAREFL 291
|
|
| OpuBB |
COG1174 |
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ... |
3-208 |
2.06e-94 |
|
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];
Pssm-ID: 440787 [Multi-domain] Cd Length: 212 Bit Score: 285.41 E-value: 2.06e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 3 SLFVTFQNRFNEWLAALGEHLQISLLSLMIALLIGVPLAALLSRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGIGTL 82
Cdd:COG1174 4 SLIEWLADNRDGILALLLEHLLLVLLALLIALLIAVPLGILITRRRRLAGLVLGVANILQTIPSLALLALLIPLLGIGPA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 83 PAVTALVIYAIFPILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIGAG 162
Cdd:COG1174 84 PAIIALVLYALLPILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVILAGIRTAAVQNIGTATLAALIGAG 163
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 489079873 163 GLGSFILLGIDRNNANLILIGAISSALLAIIFNSLLQYLEKASLRR 208
Cdd:COG1174 164 GLGDLIFDGLQLNNTALILAGAILVALLALLVDLLLALLERLLTPR 209
|
|
| OpuAC |
pfam04069 |
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity ... |
237-500 |
1.10e-64 |
|
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation. This domain is often fused to the permease component of the transporter complex. Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis. The family member OpuBC is closely related, and involved in choline transport. Choline is necessary for the biosynthesis of glycine betaine. L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA).
Pssm-ID: 397954 [Multi-domain] Cd Length: 257 Bit Score: 210.26 E-value: 1.10e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 237 DTVVIAGKLGAEPDILINLYKELIEdQSDISVElKSNFGKTSFLYEALKSGDIDMYP-EFTGTitssllrdkpplsndpk 315
Cdd:pfam04069 1 KTIVIGSKNWTEQEILANIAAQLLE-ALGYVVE-LVGLGSSAVLFAALASGDIDLYPeEWTGT----------------- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 316 qVYEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQS----- 390
Cdd:pfam04069 62 -TYEAYKKAVEEKLGLLVLGPLGAGNTYGLAVPKYVAEKPGIKSISDLAKPADDLELGFKGEFIGRPDGWGCMRStegll 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 391 -QYGLQL------SVATMePALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPP-YQGAPLMKTSLLTKHPEL 462
Cdd:pfam04069 141 kAYGLDKyelvegSEAAM-DALIYAAYKRGEPDVVYAWTPDWMIKKYDLVVLEDPKGLFPPaYNVVPVVRKGFAEKHPEV 219
|
250 260 270
....*....|....*....|....*....|....*...
gi 489079873 463 KGILNQLagKITEKEMQDMNYEVSVKGADANKVARDYL 500
Cdd:pfam04069 220 AAFLNKL--SLDTEDLNELNAQVDVEGKDPEEVAKDWL 255
|
|
| PRK10952 |
PRK10952 |
proline/glycine betaine ABC transporter permease ProW; |
23-208 |
7.45e-28 |
|
proline/glycine betaine ABC transporter permease ProW;
Pssm-ID: 236805 Cd Length: 355 Bit Score: 114.03 E-value: 7.45e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 23 LQISLLSLMIALLIGVPLAALLSRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGIGTLPAVTALVIYAIFPILQNTIT 102
Cdd:PRK10952 150 LALVLTALLFCIVIGLPLGIWLARSPRAAKIIRPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTIIFALPPIVRLTIL 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 103 GLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIGAGGLGSFILLGIDRNNANLILI 182
Cdd:PRK10952 230 GINQVPADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVGGLGQMVLRGIGRLDMGLATV 309
|
170 180
....*....|....*....|....*.
gi 489079873 183 GAISSALLAIIFNSLLQYLEKASLRR 208
Cdd:PRK10952 310 GGVGIVILAIILDRLTQAVGRDSRSR 335
|
|
| BPD_transp_1 |
pfam00528 |
Binding-protein-dependent transport system inner membrane component; The alignments cover the ... |
33-203 |
3.33e-20 |
|
Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.
Pssm-ID: 334128 [Multi-domain] Cd Length: 183 Bit Score: 88.12 E-value: 3.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 33 ALLIGVPLAalLSRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGI-----GTLPAVTALVIYAIFPILQNTITGLNGI 107
Cdd:pfam00528 1 GIPLGIIAA--LRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILsilghGILPAIILALLGWAGYARLIRRAALRSL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 108 DPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIGAG-GLGSFILLGIDRNNANLI----LI 182
Cdd:pfam00528 79 PSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWpGLGLLLIEAILGYDYPEIqgpvLA 158
|
170 180
....*....|....*....|.
gi 489079873 183 GAISSALLAIIFNSLLQYLEK 203
Cdd:pfam00528 159 AALILLLLNLLVDILQRLLDP 179
|
|
| TM_PBP2 |
cd06261 |
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ... |
19-193 |
5.19e-19 |
|
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.
Pssm-ID: 119394 [Multi-domain] Cd Length: 190 Bit Score: 85.02 E-value: 5.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 19 LGEHLQISLLSLMIALLIGVPLAALLSRSKRWSD-IMLQVTGVFQTIPSLALLGLFIPLMG---------IGTLPAVTAL 88
Cdd:cd06261 1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDrLLRRIIDLLLSLPSLVLGLLLVLLFGvllgwgilpGLGLPALILA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 89 VIYAIFPILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIGAG---GLG 165
Cdd:cd06261 81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGeapGPG 160
|
170 180
....*....|....*....|....*...
gi 489079873 166 SFILLGIDRNNANLILIGAISSALLAII 193
Cdd:cd06261 161 TGLLLIFAILFPGDLGVAAAVALILLLL 188
|
|
| PhnE |
TIGR01097 |
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ... |
10-165 |
7.86e-10 |
|
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]
Pssm-ID: 273441 [Multi-domain] Cd Length: 250 Bit Score: 59.48 E-value: 7.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 10 NRFNEWLAALGEHLQISLLSLMIALLIGVPLAAL----LSRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGIGTLPAV 85
Cdd:TIGR01097 51 SYLPRILKALLETLAMAILGTVLAAVLAVPLALLaarnITPSPWLYGLARLLLNFLRAIPELVWALIFVAAVGLGPFAGV 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 86 TALVIYAIFPILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMS--------GVRTSAVMiigtatlaS 157
Cdd:TIGR01097 131 LALAFHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVLPQFLSytlyrfeiNVRAAAVL--------G 202
|
....*...
gi 489079873 158 LIGAGGLG 165
Cdd:TIGR01097 203 LVGAGGIG 210
|
|
| ABC_perm1 |
NF038017 |
ABC transporter permease; Proteins of this family are the permease subunit of an ABC ... |
23-128 |
2.32e-05 |
|
ABC transporter permease; Proteins of this family are the permease subunit of an ABC transporter complex, which may be involved in tungstate uptake.
Pssm-ID: 411610 [Multi-domain] Cd Length: 184 Bit Score: 45.23 E-value: 2.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 23 LQISLLSLMIALLIGVPLAALLS----RSKRWsdimlqVTGVFQTIPSL--ALLGLFI--------PLMGIGTLPAVTAL 88
Cdd:NF038017 2 LRVSGTATLIAALIGIPLGALLAlrrfPGRRL------VISLLNTLMGLppVVVGLIVylllsrsgPLGFLGLLYTPTAM 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 489079873 89 VI---YAIFPILQN-TITGLNGIDPSLVEAGIAFGMTKWERLKT 128
Cdd:NF038017 76 IIaqaVLALPIVAGlTLAAVQGLDPELRLQILSLGATRWQALWT 119
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PBP2_ChoS |
cd13610 |
Substrate-binding domain ChoS of an osmoregulated ABC-type transporter and related proteins; ... |
238-500 |
1.03e-157 |
|
Substrate-binding domain ChoS of an osmoregulated ABC-type transporter and related proteins; type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein ChoS of Lactococcus lactis is predicted to be involved in uptake of compatible solutes such as choline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. ChoS belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270328 Cd Length: 264 Bit Score: 448.58 E-value: 1.03e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 238 TVVIAGKLGAEPDILINLYKELIEDQS-DISVELKSNFGKTSFLYEALKSGDIDMYPEFTGTITSSLLRDkPPLSNDPKQ 316
Cdd:cd13610 1 SIVIAGKLGSEPDILINMYKLLIEEETpDLQVTLKPNFGKTSFLFNALKSGDIDIYPEFTGTVLETLLKE-PPKSNDPME 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 317 VYEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQSQYGLQL 396
Cdd:cd13610 80 VYEQARDGLAKQYQLTYLKPMAYNNTYALAVKKEFAKQHNLKTISDLQKVQDKLKAGFTLEFMDREDGYKGLQKAYGLNF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 397 SVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTKHPELKGILNQLAGKITEK 476
Cdd:cd13610 160 NVKSMEPALRYQAINNGQVNVIDAYSTDSEIKQYDLVVLKDDKHLFPPYQGAPLMREEFLKKHPELVKALNKLAGKITDE 239
|
250 260
....*....|....*....|....
gi 489079873 477 EMQDMNYEVSVKGADANKVARDYL 500
Cdd:cd13610 240 EMQEMNYRVDVKHKSAAKVAKEYL 263
|
|
| OsmF |
COG1732 |
Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system ... |
207-500 |
2.49e-125 |
|
Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441338 [Multi-domain] Cd Length: 294 Bit Score: 367.55 E-value: 2.49e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 207 RRIMISFGITLLALLASYtpmALSQFSKGKDTVVIAGKLGAEPDILINLYKELIEDQsDISVELKSNFGKTSFLYEALKS 286
Cdd:COG1732 3 RLLLLALALAAALALAGC---GLASAAAAGDTIVVGSKNFTEQEILAEIYAQALEAA-GLKVERKLNLGGTEVVRQALKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 287 GDIDMYPEFTGTITSSLLRDKPplSNDPKQVYEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAH 366
Cdd:COG1732 79 GEIDLYPEYTGTALTTYLKEDP--ITDPEEVYEAVKEALPEKNGLTWLDPAGFNNTYALAVTKETAEKYGLKTISDLAKV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 367 ADTLKAGFTLEFKDRADGYKGMQSQYGLQL-SVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPY 445
Cdd:COG1732 157 AGELTLGADPEFAERPDGLPGLKKAYGFEFkEVKPMDTGLTYTALANGQVDVADAYTTDGRIAALDLVVLEDDKNFFPPY 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 489079873 446 QGAPLMKTSLLTKHPELKGILNQLAGKITEKEMQDMNYEVSVKGADANKVARDYL 500
Cdd:COG1732 237 NAAPLVRKEVLEKYPELAEVLNKLSGKLTTETMQELNYQVDVDGEDPADVAREFL 291
|
|
| PBP2_osmoprotectants |
cd13528 |
Substrate-binding domain of osmoregulatory ABC-type transporters; the type 2 ... |
238-500 |
3.84e-116 |
|
Substrate-binding domain of osmoregulatory ABC-type transporters; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding component of ABC transport systems that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, bacteria and archaea accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270246 [Multi-domain] Cd Length: 264 Bit Score: 343.04 E-value: 3.84e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 238 TVVIAGKLGAEPDILINLYKELIEDQSDISVELKSNFGKTSFLYEALKSGDIDMYPEFTGTITSSLLRDKPPLSnDPKQV 317
Cdd:cd13528 1 TIVVGSKNFTEQYILGEMLAQLLEANTDLTVERKLNLGGTEVAFNALKNGDIDLYVEYTGTALLTILKEDAPIT-DPEEV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 318 YEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQSQYGLQL- 396
Cdd:cd13528 80 YEKVKKEYEEKFGLTWLDPLGFNNTYALAVRKDTAEKYGLKTISDLAPHSDQLVFGADPEFYERSDGLPGLKKTYGFDFk 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 397 SVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTKHPELKGILNQLAGKITEK 476
Cdd:cd13528 160 EVKTMDPGLTYEALDNGEVDVIDAFSTDGRIKAFDLVVLEDDKNFFPPYNAAPVVREDVLKKHPELEEVLNKLSGKLTDE 239
|
250 260
....*....|....*....|....
gi 489079873 477 EMQDMNYEVSVKGADANKVARDYL 500
Cdd:cd13528 240 TMQQLNYQVDVEGKDPEEVARDFL 263
|
|
| PBP2_Opu_like_1 |
cd13609 |
Substrate-binding domain of putative ABC-type osmoprotectant uptake system; the type 2 ... |
238-500 |
3.62e-107 |
|
Substrate-binding domain of putative ABC-type osmoprotectant uptake system; the type 2 periplasmic-binding protein fold; This group includes the periplasmic substrate-binding component of a putative ABC transport system that is predicted to be involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. The relative substrate preference of this group is not known. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270327 Cd Length: 263 Bit Score: 319.93 E-value: 3.62e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 238 TVVIAGKLGAEPDILINLYKELIEDQSDISVELKSNFGKTSFLYEALKSGDIDMYPEFTGTITSSLLrdKPPLSNDPKQV 317
Cdd:cd13609 1 TIVIGSKNFTEQLILGNMYADLIEANTDIKVERKLNLGGSSVCFSALKNGDIDMYVDYTGTILVNIL--KEPPISDPDEV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 318 YEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQSQYGLQL- 396
Cdd:cd13609 79 YNTVKELMKEKYNLEVLKPLGFNNTYTLAVRKETAEKYNLKTISDLAKVSDELTLGCTLEFLNREDGLPGLEKTYGLNFk 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 397 SVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTKHPELKGILNQLAGKITEK 476
Cdd:cd13609 159 DVKGLDGSLRYTALENGEVDVIDAFSTDGLLKKFDLVVLEDDKNFFPPYYAVPLVREETLEKYPELEDVLNKLAGKISEE 238
|
250 260
....*....|....*....|....
gi 489079873 477 EMQDMNYEVSVKGADANKVARDYL 500
Cdd:cd13609 239 TMRELNYKVDELGKDPEDVAHEFL 262
|
|
| OpuBB |
COG1174 |
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ... |
3-208 |
2.06e-94 |
|
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];
Pssm-ID: 440787 [Multi-domain] Cd Length: 212 Bit Score: 285.41 E-value: 2.06e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 3 SLFVTFQNRFNEWLAALGEHLQISLLSLMIALLIGVPLAALLSRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGIGTL 82
Cdd:COG1174 4 SLIEWLADNRDGILALLLEHLLLVLLALLIALLIAVPLGILITRRRRLAGLVLGVANILQTIPSLALLALLIPLLGIGPA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 83 PAVTALVIYAIFPILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIGAG 162
Cdd:COG1174 84 PAIIALVLYALLPILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVILAGIRTAAVQNIGTATLAALIGAG 163
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 489079873 163 GLGSFILLGIDRNNANLILIGAISSALLAIIFNSLLQYLEKASLRR 208
Cdd:COG1174 164 GLGDLIFDGLQLNNTALILAGAILVALLALLVDLLLALLERLLTPR 209
|
|
| PBP2_QAT_like |
cd13614 |
Substrate-binding domain of quaternary amine ABC-type transporter; the type 2 ... |
238-500 |
3.92e-82 |
|
Substrate-binding domain of quaternary amine ABC-type transporter; the type 2 periplasmic-binding protein fold; This group includes the periplasmic substrate-binding component of a putative quaternary amine ABC transport system that is predicted to be involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. The relative substrate preference of this group is not known. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270332 Cd Length: 264 Bit Score: 255.77 E-value: 3.92e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 238 TVVIAGKLGAEPDILINLYKELIEDqSDISVELKSNFGKTSFLYEALKSGDIDMYPEFTGTITSSLLrdKPPLSNDPKQV 317
Cdd:cd13614 1 AIRVGSKNFTEQFILGEMYALALED-AGIKVERKLNLGGTLIAHQALVNGEIDLYPEYTGTALLTVL--KGEPSSDAKQV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 318 YEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQSQYG---L 394
Cdd:cd13614 78 YKTVKDAYAEQFQLTWLEPAPFNNTYALVMTRETAEKYGIKTLSDLAKAAGELVFGGGPEFQDREDGLPGLKAKYGafdF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 395 QLSVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTKHPELKGILNQLAGKIT 474
Cdd:cd13614 158 KEFVQVDPLGLRYQALAQGQIDVAVGFGTDGQIAAYGLVVLEDDKNLFPPYQVAPVVRQDVLDANPKIAEVLNKLSALLD 237
|
250 260
....*....|....*....|....*.
gi 489079873 475 EKEMQDMNYEVSVKGADANKVARDYL 500
Cdd:cd13614 238 NETMQRLNYEVDGNKREPKDVAREFL 263
|
|
| PBP2_AfProX_like |
cd13607 |
Substrate-binding protein ProX of ABC-type osmoregulatory transporter from Archaeoglobus ... |
238-500 |
8.36e-80 |
|
Substrate-binding protein ProX of ABC-type osmoregulatory transporter from Archaeoglobus fulgidus and its related proteins; the type 2 periplasmic-binding protein fold; This subfamily includes the periplasmic substrate-binding protein ProX from the hyperthermophilic archaeon Archaeoglobus fulgidus and its related proteins. AfProX is involved in uptake of compatible solutes such as the trimethylammonium compound glycine betaine and the dimethylammonium compound proline betaine, but the relative substrate preference is not known. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. AfProX belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270325 Cd Length: 261 Bit Score: 249.81 E-value: 8.36e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 238 TVVIAGKLGAEPDILINLYKELIEDQSdISVELKSNFGKTSFLYEALKSGDIDMYPEFTGTITSSLLrdKPPLSNDPKQV 317
Cdd:cd13607 1 TVVIGSKTFTEQYILAEMIAQLLEEAG-YPAEHREGLGGTRVLFEALKSGEIDVYVEYTGTLYAEIL--KRPETWDPAAV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 318 YEDAKKGIAKQDkLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQSQYGL-QL 396
Cdd:cd13607 78 LAELKEALAERG-IVVAGPLGFENTYALAMREDRAEALGIRTISDLLARAPDLRFGFDPEFLDRPDGWPALRRVYGLpFK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 397 SVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTKHPELKGILNQLAGKITEK 476
Cdd:cd13607 157 EVRGLDHTLAYRALKSGQVDVIDAYTTDARIDAYDLRVLEDDRGAFPPYDAVLLYRADLAERAPKAVAALRRLEGRIDAD 236
|
250 260
....*....|....*....|....
gi 489079873 477 EMQDMNYEVSVKGADANKVARDYL 500
Cdd:cd13607 237 TMRALNAQVDLEKRSEAEVAAEFL 260
|
|
| PBP2_Opu_like_2 |
cd13613 |
Substrate-binding domain of putative ABC-type osmoprotectant uptake system; the type 2 ... |
238-500 |
7.01e-79 |
|
Substrate-binding domain of putative ABC-type osmoprotectant uptake system; the type 2 periplasmic-binding protein fold; This group includes the periplasmic substrate-binding component of a putative ABC transport system that is predicted to be involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. The relative substrate preference of this group is not known. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270331 Cd Length: 264 Bit Score: 247.64 E-value: 7.01e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 238 TVVIAGKLGAEPDILINLYKELIEDQSDISVELKSNFGKTSFLYEALKSGDIDMYPEFTGTITSSLLrdKPPLSNDPKQV 317
Cdd:cd13613 1 RIIIGSKNFTEQVILGELLAQQIEARTDLKVERRFNLGGTFICHQALLSGAIDAYVEYTGTALTAIL--KQPPIRDPQRV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 318 YEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQSQYGLQL- 396
Cdd:cd13613 79 YEQVKQLYADRFGLEVMPPLGFENTFAILVRGEDARKLGLKTLSDAAPYTPGWRAGFGYEFLERADGYPGLAKTYGLKFa 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 397 -SVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTKHPELKGILNQLAGKITE 475
Cdd:cd13613 159 kTPRVMDLGLLYRALAQKQVDLIAGNSTDGLIAALDLVILEDDRHYFPPYQAVPVVRQATLAKYPELRTAIAELAGKISA 238
|
250 260
....*....|....*....|....*
gi 489079873 476 KEMQDMNYEVSVKGADANKVARDYL 500
Cdd:cd13613 239 ETMQQMNYQVDGEHRDVAEVAREFL 263
|
|
| PBP2_ProWX |
cd13612 |
Substrate-binding protein ProWX of ABC-type osmoregulated transporter and its related proteins; ... |
238-505 |
1.19e-77 |
|
Substrate-binding protein ProWX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein ProWX of Helicobacter pylori is predicted to be involved in uptake of compatible solutes such as choline, L-proline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. ProWX belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270330 Cd Length: 267 Bit Score: 244.45 E-value: 1.19e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 238 TVVIAGKLGAEPDILINLYKELIEDQSDISVELKSNF-GKTSFLYEALKSGDIDMYPEFTGTITSSLLRDKpplSNDPKQ 316
Cdd:cd13612 1 TIHIATKPMTEQYILGEMLKQLIEQDTDLKVELTKGVgGGTSNIHPAMVKGEFDLYPEYTGTGWLFVLKKD---GTYSEE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 317 VYEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQSQYGLQL 396
Cdd:cd13612 78 LFDQLQKEYEEKYNLTWLGLYGFNNTYGLAVRKELAEKYNLKTYSDLAKVSNQLVFGAEYDFFEREDGYDALQKAYGFNF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 397 -SVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTKHPELKGILNQLAGKITE 475
Cdd:cd13612 158 kKTVDMDIGLKYQAIESGKVDVINVFTTDGQLSDADIVVLEDDKGFFPSYYAGTVVREETLEKYPELEDVLEKLTGLISD 237
|
250 260 270
....*....|....*....|....*....|
gi 489079873 476 KEMQDMNYEVSVKGADANKVARDYLLKTGL 505
Cdd:cd13612 238 EDMAEMNYQVEIEKKDPKDVAKEFLEEKGL 267
|
|
| PBP2_OpuCC_like |
cd13608 |
Substrate-binding protein OpuCC of ABC-type osmoregulatory transporter and related proteins; ... |
238-500 |
2.15e-76 |
|
Substrate-binding protein OpuCC of ABC-type osmoregulatory transporter and related proteins; the type 2 periplasmic-binding protein fold; This subfamily includes the periplasmic substrate-binding protein OpuCC of the ABC transporter OpuC (where Opu is osmoprotectant uptake), which can recognize a broad spectrum of compatible solutes, and its paralog OpuBC that can solely bind choline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270326 Cd Length: 265 Bit Score: 240.99 E-value: 2.15e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 238 TVVIAGKLGAEPDILINLYKELIEDQSDISVELKSNFGKTSFLYEALKSGDID-MYPEFTGTITSSLLRDKPplSNDPKQ 316
Cdd:cd13608 1 TIRIGSQSTTESQILAEMVKQLIEHYTDLKVELINNLGSSTVQHQAMLNGDANiSAARYTGTDLTGELGMEP--IKDPEK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 317 VYEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDR-ADGYKGMQSQYGLQ 395
Cdd:cd13608 79 ALKVVQKEFQKRFDQTWFDSYGFANTYAFMVTKEFAEKYNLKKVSDLKKVADNLKLGVDTSWLNRkGDGYPGFKETYGFD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 396 L-SVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTKHPELKGILNQLAGKIT 474
Cdd:cd13608 159 FgTVYPMQIGLVYDAVASGKMDVVLGYSTDGRIKSYDLVVLEDDKQFFPPYDASPVATNEILKKYPELEEILEKLEGKIS 238
|
250 260
....*....|....*....|....*.
gi 489079873 475 EKEMQDMNYEVSVKGADANKVARDYL 500
Cdd:cd13608 239 TETMQELNYQVDNDLKEPSVVAKEFL 264
|
|
| PBP2_ProWY |
cd13615 |
Substrate-binding domain of ABC-type osmoregulated transporter; the type 2 periplasmic-binding ... |
238-501 |
2.18e-66 |
|
Substrate-binding domain of ABC-type osmoregulated transporter; the type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein ProWY of Streptococcus thermophilus is predicted to be involved in uptake of compatible solutes such as choline, L-proline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. ProWY belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270333 Cd Length: 262 Bit Score: 215.00 E-value: 2.18e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 238 TVVIAGKLGAEPDILINLYKELIEDQSdISVELKSNFGkTSFLYEALKSGDIDMYPEFTGTITSSLLrdKPPLSNDPKQV 317
Cdd:cd13615 1 AIRVGSKDFTENLIVAEIYALALEDAG-YKVKRKPNIS-SSVVHQALTSGQIDLYPEYTGTGLLAVL--KKEAITDPQKV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 318 YEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQSQYGLQ-- 395
Cdd:cd13615 77 YATVKDGYAKKFNLVWLDYAPANDGQGLVIRTSVAKKYGIKTISDLQKNASQIRFASQGEFDQREDGLPGLEKVYGKFsf 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 396 LSVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTKHPELKGILNQLAGKITE 475
Cdd:cd13615 157 KSTKVYDNGLKYQVLANDKADITPAYTTEGQLDTSKFTLLKDDKHVWPPYNLAPVVRKDVLKANPKIASALNKVSAKLTT 236
|
250 260
....*....|....*....|....*.
gi 489079873 476 KEMQDMNYEVSVKGADANKVARDYLL 501
Cdd:cd13615 237 KTLTQLNAKVDVDKQEYADVAKDFYL 262
|
|
| OpuAC |
pfam04069 |
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity ... |
237-500 |
1.10e-64 |
|
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation. This domain is often fused to the permease component of the transporter complex. Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis. The family member OpuBC is closely related, and involved in choline transport. Choline is necessary for the biosynthesis of glycine betaine. L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA).
Pssm-ID: 397954 [Multi-domain] Cd Length: 257 Bit Score: 210.26 E-value: 1.10e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 237 DTVVIAGKLGAEPDILINLYKELIEdQSDISVElKSNFGKTSFLYEALKSGDIDMYP-EFTGTitssllrdkpplsndpk 315
Cdd:pfam04069 1 KTIVIGSKNWTEQEILANIAAQLLE-ALGYVVE-LVGLGSSAVLFAALASGDIDLYPeEWTGT----------------- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 316 qVYEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQS----- 390
Cdd:pfam04069 62 -TYEAYKKAVEEKLGLLVLGPLGAGNTYGLAVPKYVAEKPGIKSISDLAKPADDLELGFKGEFIGRPDGWGCMRStegll 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 391 -QYGLQL------SVATMePALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPP-YQGAPLMKTSLLTKHPEL 462
Cdd:pfam04069 141 kAYGLDKyelvegSEAAM-DALIYAAYKRGEPDVVYAWTPDWMIKKYDLVVLEDPKGLFPPaYNVVPVVRKGFAEKHPEV 219
|
250 260 270
....*....|....*....|....*....|....*...
gi 489079873 463 KGILNQLagKITEKEMQDMNYEVSVKGADANKVARDYL 500
Cdd:pfam04069 220 AAFLNKL--SLDTEDLNELNAQVDVEGKDPEEVAKDWL 255
|
|
| PBP2_YehZ |
cd13611 |
Substrate-binding domain YehZ of an osmoregulated ABC-type transporter; the type 2 ... |
268-500 |
5.10e-60 |
|
Substrate-binding domain YehZ of an osmoregulated ABC-type transporter; the type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein YehZ of Clostridium sticklandii is predicted to be involved in uptake of compatible solutes such as choline, L-proline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. YehZ belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270329 Cd Length: 267 Bit Score: 198.58 E-value: 5.10e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 268 VELKSNFGKTSFLYEALKSGDIDMYPEFTGTITSSLLR-DKPPLsnDPKQVYE-----DAKKGiakqdkLTLLKPFAYQN 341
Cdd:cd13611 30 VTDKTNLGGSASARQALENGQVDVYWEYTGTAWITYLGhTEPIL--DPQEQYEavkdlDAEKG------LVWLDPAPLNN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 342 TYAVAMPEKLAKEYQIETISDL---KAHADTLKAGFTLEFKDRADGYKGMQSQYGLQLS---VATMEPALRYQAIQSGDI 415
Cdd:cd13611 102 TYALAMREATAEELGITTLSDLalaKLPPGDRTFCVDAEFASRPDGLPPLLEAYGFEFPranVRQMDTGLVYTATANGQC 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 416 QVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTKHPELKGILNQLAGKITEKEMQDMNYEVSVKGADANKV 495
Cdd:cd13611 182 DFGEVFTTDGRIKALDLVVLEDDKGFFPAYNAAPVVRTEVLDAHPELAEILNPISAKLDNDTMQELNARVDVDGEDPADV 261
|
....*
gi 489079873 496 ARDYL 500
Cdd:cd13611 262 ARDWL 266
|
|
| PBP2_OsmF |
cd13616 |
Substrate-binding domain OsmF of an osmoregulated ABC-type transporter; the type 2 ... |
238-500 |
6.07e-50 |
|
Substrate-binding domain OsmF of an osmoregulated ABC-type transporter; the type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein OsmF of an ABC transporter (YehZYXW) from Escherichia coli is predicted to be involved in uptake of compatible solutes such as choline, L-proline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. OsmF belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270334 Cd Length: 274 Bit Score: 172.13 E-value: 6.07e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 238 TVVIAGKLGAEPDILINLYKELIEDQSdISVELKSNFGKTSFLYEALKSGDIDMYPEFTGTITSSLLRDKPPLSNDPKQV 317
Cdd:cd13616 1 PVVVGSKIDTEGALLGNMIVLALEAHG-FPVEDKTGLGTTPVVRKALLSGEIDLYPEYTGNGAFFFPEADDPVWKDARKG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 318 YEDAKKGIAKQDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHAD---TLK-AGFTlEFKDRADGYKGMQSQYG 393
Cdd:cd13616 80 YETVKELDAKNNGLVWLDPAPANNTWAIAVRRDLAEKNNLKTLADLAAYVNeggAFKlAASA-EFVERPDALPAFEKAYG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 394 LQLS------VATMEPALRYQAIQSGDIQVTDA--YSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTKHPELKGI 465
Cdd:cd13616 159 FKLSkdqlviLSGGNTAQTEQAAAQGTSGVNAAmaYGTDGAIAALGLVVLEDPKGAQPVYAPAPVVRQEVLEAYPEIAEI 238
|
250 260 270
....*....|....*....|....*....|....*
gi 489079873 466 LNQLAGKITEKEMQDMNYEVSVKGADANKVARDYL 500
Cdd:cd13616 239 LKPVFATLDLKTLQELNARIAVEGESAEDVARDYL 273
|
|
| PBP2_ProX_like |
cd13606 |
Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related ... |
238-500 |
1.07e-48 |
|
Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold; This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270324 Cd Length: 260 Bit Score: 168.51 E-value: 1.07e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 238 TVVIAGKLGAEPDILINLYKELIEDqSDISVELKSNFGKTSFLYEALKSGDIDMYPEFTGTITSSLlrDKPPLSNDPKQV 317
Cdd:cd13606 1 TVVVGSADFPESEILAEIYAQALEA-AGVKVTRKLNIGSREVYLPALEDGSIDLVPEYTGNLLQYL--DKDATATDPEEV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 318 YEDAKKGIAkqDKLTLLKPFAYQNTYAVAMPEKLAKEYQIETISDLKAHADTLKAGFTLEFKDRADGYKGMQSQYGL--- 394
Cdd:cd13606 78 YAALKAALP--EGLEVLDPSPAEDKDALVVTKETAEKYGLKSIADLAPVAGELTLGGPPEFKTRPYGLPGLKEVYGVtfk 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 395 QLSVATMEPALRYQAIQSGDIQVTDAYSTDAEITKYHLKVLKDDKQLFPPYQGAPLMKTSLLTkhPELKGILNQLAGKIT 474
Cdd:cd13606 156 EFKPLDAGGPLTVKALKDGTVQVANIFTTDPAIADNGLVVLEDPKNLFPAQNVVPLVRKAKLD--DKAADALNAVSAKLT 233
|
250 260
....*....|....*....|....*.
gi 489079873 475 EKEMQDMNYEVSVKGADANKVARDYL 500
Cdd:cd13606 234 TEDLTELNKQVVGDKADPADVAKEWL 259
|
|
| TauC |
COG0600 |
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ... |
19-208 |
2.05e-37 |
|
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];
Pssm-ID: 440365 [Multi-domain] Cd Length: 254 Bit Score: 137.97 E-value: 2.05e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 19 LGEHLQISL----LSLMIALLIGVPLAALLSRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGIGTLPAVTALVIYAIF 94
Cdd:COG0600 59 LWEHLLASLlrvlLGFALAALLGVPLGLLLGLSRLLRRLLDPLLVFLRPIPPLALAPLLILWFGIGEASKIFVIFLGAFF 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 95 PILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIGAG-GLGSFILLGID 173
Cdd:COG0600 139 PILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGLRIALGLAWIGLVVAELLGASsGLGYLILDARQ 218
|
170 180 190
....*....|....*....|....*....|....*
gi 489079873 174 RNNANLILIGAISSALLAIIFNSLLQYLEKASLRR 208
Cdd:COG0600 219 LLDTDLVFAAILVIGLLGLLLDLLLRLLERRLLRW 253
|
|
| ProW |
COG4176 |
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ... |
27-199 |
1.26e-35 |
|
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];
Pssm-ID: 443335 Cd Length: 275 Bit Score: 133.68 E-value: 1.26e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 27 LLSLMIALLIGVPLAALLSRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGIGTLPAVTALVIYAIFPILQNTITGLNG 106
Cdd:COG4176 100 LVAVLIALLIGIPLGILAARSDRVSRIVRPVLDFMQTMPAFVYLIPAVMLFGIGKVPGVIATVIFALPPAIRLTNLGIRQ 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 107 IDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIGAGGLGSFILLGIDRNNANLILIGAIS 186
Cdd:COG4176 180 VPKELVEAADAFGATPWQLLFKVQLPLALPTIMAGVNQTIMLALSMVVIASMIGAGGLGQEVLRALQRLDIGLGFEAGLA 259
|
170
....*....|...
gi 489079873 187 SALLAIIFNSLLQ 199
Cdd:COG4176 260 IVILAIILDRITQ 272
|
|
| PRK10952 |
PRK10952 |
proline/glycine betaine ABC transporter permease ProW; |
23-208 |
7.45e-28 |
|
proline/glycine betaine ABC transporter permease ProW;
Pssm-ID: 236805 Cd Length: 355 Bit Score: 114.03 E-value: 7.45e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 23 LQISLLSLMIALLIGVPLAALLSRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGIGTLPAVTALVIYAIFPILQNTIT 102
Cdd:PRK10952 150 LALVLTALLFCIVIGLPLGIWLARSPRAAKIIRPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTIIFALPPIVRLTIL 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 103 GLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIGAGGLGSFILLGIDRNNANLILI 182
Cdd:PRK10952 230 GINQVPADLIEASRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVGGLGQMVLRGIGRLDMGLATV 309
|
170 180
....*....|....*....|....*.
gi 489079873 183 GAISSALLAIIFNSLLQYLEKASLRR 208
Cdd:PRK10952 310 GGVGIVILAIILDRLTQAVGRDSRSR 335
|
|
| BPD_transp_1 |
pfam00528 |
Binding-protein-dependent transport system inner membrane component; The alignments cover the ... |
33-203 |
3.33e-20 |
|
Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.
Pssm-ID: 334128 [Multi-domain] Cd Length: 183 Bit Score: 88.12 E-value: 3.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 33 ALLIGVPLAalLSRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGI-----GTLPAVTALVIYAIFPILQNTITGLNGI 107
Cdd:pfam00528 1 GIPLGIIAA--LRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILsilghGILPAIILALLGWAGYARLIRRAALRSL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 108 DPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIGAG-GLGSFILLGIDRNNANLI----LI 182
Cdd:pfam00528 79 PSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWpGLGLLLIEAILGYDYPEIqgpvLA 158
|
170 180
....*....|....*....|.
gi 489079873 183 GAISSALLAIIFNSLLQYLEK 203
Cdd:pfam00528 159 AALILLLLNLLVDILQRLLDP 179
|
|
| MetP |
COG2011 |
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ... |
4-201 |
1.17e-19 |
|
ABC-type methionine transport system, permease component [Amino acid transport and metabolism];
Pssm-ID: 441614 Cd Length: 220 Bit Score: 87.42 E-value: 1.17e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 4 LFVTFQNRFNEWLAALGEHLQISLLSLMIALLIGVPLAALL---SRSKRWSDIML-QVTG----VFQTIPSLALLGLFIP 75
Cdd:COG2011 1 MLTMWSELWPLLLQATGETLYMVGVSTLIAVLLGLPLGVLLvltRPGGLLPNPVLyRVLGvivnIFRSIPFIILLVALIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 76 L----MG--IGTLPAVTALVIYAIFPILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMI 149
Cdd:COG2011 81 LtrliVGtsIGTTAAIVPLTIAAIPFFARLVENALREVDPGVIEAAQAMGASPWQIIFKVLLPEALPSLILGLTVTLISL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 489079873 150 IGTATLASLIGAGGLGSF-ILLGIDRNNANLILIgaisSALLAIIFNSLLQYL 201
Cdd:COG2011 161 IGYSAMAGAVGGGGLGDLaIRYGYQRFDTDVMLV----TVVILIVLVQIIQFL 209
|
|
| TM_PBP2 |
cd06261 |
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ... |
19-193 |
5.19e-19 |
|
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.
Pssm-ID: 119394 [Multi-domain] Cd Length: 190 Bit Score: 85.02 E-value: 5.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 19 LGEHLQISLLSLMIALLIGVPLAALLSRSKRWSD-IMLQVTGVFQTIPSLALLGLFIPLMG---------IGTLPAVTAL 88
Cdd:cd06261 1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDrLLRRIIDLLLSLPSLVLGLLLVLLFGvllgwgilpGLGLPALILA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 89 VIYAIFPILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIGAG---GLG 165
Cdd:cd06261 81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGeapGPG 160
|
170 180
....*....|....*....|....*...
gi 489079873 166 SFILLGIDRNNANLILIGAISSALLAII 193
Cdd:cd06261 161 TGLLLIFAILFPGDLGVAAAVALILLLL 188
|
|
| PhnE |
COG3639 |
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ... |
10-182 |
8.57e-14 |
|
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];
Pssm-ID: 442856 [Multi-domain] Cd Length: 244 Bit Score: 70.88 E-value: 8.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 10 NRFNEWLAALGEHLQISLLSLMIALLIGVPLAAL----LSRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGIGTLPAV 85
Cdd:COG3639 44 SYLPDLLSALLETLAIALLGTLLGAVLALPLAFLaarnLAPNPWVRLLARRLLNVLRAIPELVWALIFVAAVGLGPFAGV 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 86 TALVIYAIfpilqntitG---------LNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMS--------GVRTSAVM 148
Cdd:COG3639 124 LALAIHTI---------GflgklfaeaIEEIDPGPVEALRATGASRLQVIRYGVLPQVLPQFLSytlyrfeiNIRAATVL 194
|
170 180 190
....*....|....*....|....*....|....*..
gi 489079873 149 iigtatlaSLIGAGGLGSFILLGIDR---NNANLILI 182
Cdd:COG3639 195 --------GLVGAGGIGLLLNEAIRLfqyDEVAAILL 223
|
|
| ssuC |
PRK11365 |
aliphatic sulfonate ABC transporter permease SsuC; |
16-207 |
3.49e-13 |
|
aliphatic sulfonate ABC transporter permease SsuC;
Pssm-ID: 183100 Cd Length: 263 Bit Score: 69.58 E-value: 3.49e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 16 LAALGE---HLQISLLSLMIALLIGVPLA---ALLSRSKRWSDIMLQVT-GVFQTIPSLALLGLFIPLMGIGTLPAVTAL 88
Cdd:PRK11365 52 LSASGElwqHLAISSWRALIGFSIGGSLGlilGLISGLSRWGERLLDTSiQMLRNVPHLALIPLVILWFGIDESAKIFLV 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 89 VIYAIFPILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIGA-GGLGSF 167
Cdd:PRK11365 132 ALGTLFPIYINTWHGIRNIDRGLVEMARSYGLSGIPLFIHVILPGALPSIMVGVRFALGLMWLTLIVAETISAnSGIGYL 211
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 489079873 168 ILLGIDRNNANLILIGAISSALLAIIFNSLLQYLEKASLR 207
Cdd:PRK11365 212 AMNAREFLQTDVVVVAIILYALLGKLADVSAQLLERLWLR 251
|
|
| ProX |
COG2113 |
ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport ... |
206-500 |
3.89e-13 |
|
ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport and metabolism];
Pssm-ID: 441716 [Multi-domain] Cd Length: 297 Bit Score: 69.88 E-value: 3.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 206 LRRIMISFGITLLALLASyTPMALSQFSKGKDTVVIAGklGAEPDILI--NLYKELIEDQsDISVELKSnfGKTSFLYEA 283
Cdd:COG2113 1 MKKLLLLLLAAALALALA-GCAAAAAAPGSCKTVTIAD--VGWTSATAttAVAKQILEEL-GYEVELVE--LDVPVTYQG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 284 LKSGDIDMYPEftgtitssllrdkpplSNDP--KQVYEDAKKgiakQDKLTLLKPF---AYQnTYAVamPEKLAkEYQIE 358
Cdd:COG2113 75 LANGDIDVFLE----------------AWLPttHADYDEAYG----DGKVEDLGTNyegAKQ-GLAV--PKYVA-EPGIK 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 359 TISDLKAHADtlkagftlEFKDR-------ADGYKGMQSQ---YGL------QLSVATMEPALRyQAIQSGD-IQVTdAY 421
Cdd:COG2113 131 SIADLKKYAD--------LFDGKiygiepgWGCNRVIEEAikaYGLddfelvEGSEAAMLAALA-RAYKRGEpIVFY-GW 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 422 STDAEITKYHLKVLKDDKQLFPPYQGAPLMKT----SLLTKHPELKGILNQLagKITEKEMQDMNYEVSVKGADANKVAR 497
Cdd:COG2113 201 TPHWMFAKYDLKYLEDPKGAFGPNFPAETVHTvarkGFAEDNPEAAKLLENF--KFTLEDINALMAAIENDGADPEEAAK 278
|
...
gi 489079873 498 DYL 500
Cdd:COG2113 279 EWL 281
|
|
| FbpB |
COG1178 |
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; |
23-163 |
5.43e-11 |
|
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
Pssm-ID: 440791 [Multi-domain] Cd Length: 538 Bit Score: 64.80 E-value: 5.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 23 LQISLLSLMIALLIGVPLAALLSRSK-RWSDIMLQVTGVFQTIPSLAL-LGLFIPLMGIGTLP---AVTALVI-YAI--F 94
Cdd:COG1178 344 LLLALLAALLAVLLALLLAYLVRRRRgRLARLLDRLAMLPYAVPGIVLgLGLLLLFNRPLPLLlygTLAILVLaYVVrfL 423
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 95 PI-LQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASLIGAGG 163
Cdd:COG1178 424 PFaLRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLRPPG 493
|
|
| PhnE |
TIGR01097 |
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ... |
10-165 |
7.86e-10 |
|
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]
Pssm-ID: 273441 [Multi-domain] Cd Length: 250 Bit Score: 59.48 E-value: 7.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 10 NRFNEWLAALGEHLQISLLSLMIALLIGVPLAAL----LSRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGIGTLPAV 85
Cdd:TIGR01097 51 SYLPRILKALLETLAMAILGTVLAAVLAVPLALLaarnITPSPWLYGLARLLLNFLRAIPELVWALIFVAAVGLGPFAGV 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 86 TALVIYAIFPILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMS--------GVRTSAVMiigtatlaS 157
Cdd:TIGR01097 131 LALAFHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVLPQFLSytlyrfeiNVRAAAVL--------G 202
|
....*...
gi 489079873 158 LIGAGGLG 165
Cdd:TIGR01097 203 LVGAGGIG 210
|
|
| FbpB |
COG1178 |
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; |
4-208 |
4.95e-09 |
|
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
Pssm-ID: 440791 [Multi-domain] Cd Length: 538 Bit Score: 58.63 E-value: 4.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 4 LFVTFQNRFNEWLAALGEH---------LQISLLSLMIALLIGVPLAALLSRS----KRWSDIMLQVTGVFQT-IPSLAL 69
Cdd:COG1178 32 LLRAFTDGLANFWALLSDPylwralgntLLLALLVTLLSLLLGVPLAWLLARTdfpgRRLLRWLLLLPLALPPyVVALAW 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 70 LGLF---------------IPLMGIGTLPAVTALVIYAIFP-ILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPI 133
Cdd:COG1178 112 IALFgpngllntllralfgLEPPDIYGLGGIILVLVLFNYPyVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 134 AMPVIMSGvrtsavmiigtatlASLIGAGGLGSF---ILLGID------------RNNANLILIGAISSALLAIIFnsLL 198
Cdd:COG1178 192 LRPAIAAG--------------ALLVFLLCLADFgtpLVLGGGyttlttaiyqawLGDFDLGAAAALALVLLLLVL--LL 255
|
250
....*....|
gi 489079873 199 QYLEKASLRR 208
Cdd:COG1178 256 LLLERRLRRR 265
|
|
| PRK10160 |
PRK10160 |
taurine ABC transporter permease TauC; |
17-165 |
5.06e-09 |
|
taurine ABC transporter permease TauC;
Pssm-ID: 182276 Cd Length: 275 Bit Score: 57.49 E-value: 5.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 17 AALGEHLQISLLSLMIAL----LIGVPLAALLSRSKRWSDIMLQVTGVFQTIPSLALLGLFIPLMGIGTLPAVtaLVIY- 91
Cdd:PRK10160 74 ATLWQHLAASLTRIVLALlaavVIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKI--LLIYl 151
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489079873 92 AIF-PILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSavMIIGTATL--ASLIGAG-GLG 165
Cdd:PRK10160 152 AIFaPVAMSALAGVKSAQQVRIRAAQSLGASRAQVLWFVILPGALPEILTGLRIG--LGVGWSTLvaAELIAATrGLG 227
|
|
| HisM |
COG0765 |
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ... |
5-160 |
3.45e-08 |
|
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];
Pssm-ID: 440528 [Multi-domain] Cd Length: 218 Bit Score: 53.93 E-value: 3.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 5 FVTFQNRFNEWLAALGEHLQISLLSLMIALLIGVPLAAL-LSRSKRWSDIMLQVTGVFQTIPSLALLGLF---IPLMGI- 79
Cdd:COG0765 5 FSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALArLSPNPVLRWLATAYVEFFRGTPLLVQLFFIyfgLPLLGId 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 80 --GTLPAVTALVIYA------IFpilqntITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIG 151
Cdd:COG0765 85 lsPFVAAVIALTLNSaaylaeIV------RAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLK 158
|
....*....
gi 489079873 152 TATLASLIG 160
Cdd:COG0765 159 DTSLVSVIG 167
|
|
| COG4986 |
COG4986 |
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and ... |
16-193 |
1.24e-06 |
|
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism];
Pssm-ID: 444010 [Multi-domain] Cd Length: 576 Bit Score: 51.00 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 16 LAALGehlqislLSLMIALLIGVpLAAllsRSKRWSDIMLQVTGVFQTIPSL--------ALLGLFiPlmgiGTLPAVTA 87
Cdd:COG4986 71 FAALA-------ASLLFTFVYAT-LAA---KSRRAEKILIPLLDILQSVPVLgflsftvtFFIALF-P----GSLLGVEL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 88 LVIYAIFpilqntiTG------------LNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMP-------VIMSG----VRT 144
Cdd:COG4986 135 AAIFAIF-------TSqawnmafsfyqsLRTVPRDLDEAARIFRLSGWQRFWRLELPFAMPglvwnsmMSMSGgwffLVA 207
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 489079873 145 SAVMIIG--TATLAsligagGLGSFILLGIDRNNanlilIGAISSALLAII 193
Cdd:COG4986 208 SEAISVGnqDIRLP------GIGSYLALAIAQGD-----LGAIGWAILAML 247
|
|
| PRK10782 |
PRK10782 |
D-methionine ABC transporter permease MetI; |
15-165 |
1.89e-06 |
|
D-methionine ABC transporter permease MetI;
Pssm-ID: 182726 Cd Length: 217 Bit Score: 48.96 E-value: 1.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 15 WLAALG--EHLQISLLSLMIALLIGVPLAALL--SR------SKRWSDIMLQVTGVFQTIPSLALLGLFIPLM------G 78
Cdd:PRK10782 7 WLLVRGvwETLAMTFVSGFFGFVIGLPVGVLLyvTRpgqiiaNAKLYRTLSALVNIFRSIPFIILLVWMIPFTrvivgtS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 79 IGTLPAVTALVIYAIFPILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIGTATLASL 158
Cdd:PRK10782 87 IGLQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLVGYSAMGGA 166
|
....*..
gi 489079873 159 IGAGGLG 165
Cdd:PRK10782 167 VGAGGLG 173
|
|
| PotB |
COG1176 |
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ... |
23-162 |
1.97e-06 |
|
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];
Pssm-ID: 440789 [Multi-domain] Cd Length: 287 Bit Score: 49.38 E-value: 1.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 23 LQISLLSLMIALLIGVPLAALLSR-SKRWSDIM----------------------LQVTGVFQTIpsLALLGLFIPLMGI 79
Cdd:COG1176 73 LWIALLTTLICLLLGYPIAYFLARaPPRWRNLLlllvilpfwtsflvrtyawivlLGRNGLLNSL--LLALGLIDEPLRL 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 80 gtLPAVTALVI--------YAIFPILqntiTGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIG 151
Cdd:COG1176 151 --LYTEFAVVIglvyvylpFMVLPLY----AALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALG 224
|
170
....*....|.
gi 489079873 152 TATLASLIGAG 162
Cdd:COG1176 225 AFVTPALLGGG 235
|
|
| ABC_perm1 |
NF038017 |
ABC transporter permease; Proteins of this family are the permease subunit of an ABC ... |
23-128 |
2.32e-05 |
|
ABC transporter permease; Proteins of this family are the permease subunit of an ABC transporter complex, which may be involved in tungstate uptake.
Pssm-ID: 411610 [Multi-domain] Cd Length: 184 Bit Score: 45.23 E-value: 2.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 23 LQISLLSLMIALLIGVPLAALLS----RSKRWsdimlqVTGVFQTIPSL--ALLGLFI--------PLMGIGTLPAVTAL 88
Cdd:NF038017 2 LRVSGTATLIAALIGIPLGALLAlrrfPGRRL------VISLLNTLMGLppVVVGLIVylllsrsgPLGFLGLLYTPTAM 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 489079873 89 VI---YAIFPILQN-TITGLNGIDPSLVEAGIAFGMTKWERLKT 128
Cdd:NF038017 76 IIaqaVLALPIVAGlTLAAVQGLDPELRLQILSLGATRWQALWT 119
|
|
| COG4986 |
COG4986 |
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and ... |
12-198 |
1.62e-04 |
|
ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism];
Pssm-ID: 444010 [Multi-domain] Cd Length: 576 Bit Score: 44.06 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 12 FNEWLAALGEHLqISLL----SLMIALLIGVPLAALLSRSKRWSDIMLQVTGVFQTIPSLALLGLF-------------- 73
Cdd:COG4986 361 LSEVLHVFLLGL-LTLLrvvvLIALASLIWVPVGVWIGLRPRLARRLQPVAQFLASFPANLLFPVAvllivrfglnpniw 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 74 -IPLMGIGTLpavtalvIYaifpILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAvmiiGT 152
Cdd:COG4986 440 lSPLMILGTQ-------WY----ILFNVIAGASAIPNDLREAARNFGLRGWLWWRRLILPGIFPYYVTGAITAS----GG 504
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 489079873 153 ATLASLIG-----------AGGLGSFILLGIDRNNANLILIGAISSALLAIIFNSLL 198
Cdd:COG4986 505 AWNASIVAeyvswgdttlqATGLGAYIAQATAAGDFPRILLGIAVMSLFVVLFNRLV 561
|
|
| 3a0107s02c |
TIGR00974 |
phosphate ABC transporter, permease protein PstA; This model describes PtsA, one of a pair of ... |
26-169 |
1.05e-03 |
|
phosphate ABC transporter, permease protein PstA; This model describes PtsA, one of a pair of permease proteins in the ABC (high affinity) phosphate transporter. In a number of species, this permease is fused with the PtsC protein (TIGR02138). In the model bacterium Escherichia coli, this transport system is induced when the concentration of extrallular inorganic phosphate is low. A constitutive, lower affinity transporter operates otherwise. [Transport and binding proteins, Anions]
Pssm-ID: 273373 Cd Length: 271 Bit Score: 41.07 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 26 SLLSLMIALLIGVPLAAL-------LSRSKRWSDIMLQVTGVFQTIPSLaLLGLFIPLMGIGT-------LPAVT-ALVI 90
Cdd:TIGR00974 59 TLLLTLLAIVIAVPLGIGaaiylaeYANGSRFTKIIRFAVDILAGVPSI-VVGLFGYGFFVLTylgggfsLLAGAlALAL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 91 YAIFPILQNTITGLNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSGVRTSAVMIIG-TATLasLIGAGGLGSFIL 169
Cdd:TIGR00974 138 LILPVIIRTTEEALKAVPKDLREASLALGATKWQTIFKVVLPAALPGILTGIILSIARAAGeTAPL--LFTAGGSAFTPP 215
|
|
| potC |
PRK09500 |
spermidine/putrescine ABC transporter membrane protein; Reviewed |
16-141 |
3.09e-03 |
|
spermidine/putrescine ABC transporter membrane protein; Reviewed
Pssm-ID: 236542 [Multi-domain] Cd Length: 256 Bit Score: 39.58 E-value: 3.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489079873 16 LAALGEHLQISLLSLMIALLIGVPLAALLSR----SKRWSDIMLQVTGVFQTIP-SLALLGLFIpLMGIgTLPAVTALVI 90
Cdd:PRK09500 56 LQAAQHSLTMAVFSATFATLIGSLTAVALYRyrfrGKKFVSGMLFVVMMSPDIVmAISLLVLFM-LLGI-QLGFWSLLFA 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 489079873 91 YAIF--PILQNTITG-LNGIDPSLVEAGIAFGMTKWERLKTFEIPIAMPVIMSG 141
Cdd:PRK09500 134 HITFclPFVVVTVYSrLKGFDVRMLEAAKDLGASEFTILRKIILPLALPAVAAG 187
|
|
| |
