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Conserved domains on  [gi|489081430|ref|WP_002991361|]
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MFS transporter [Streptococcus pyogenes]

Protein Classification

MDR family MFS transporter( domain architecture ID 13023665)

MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26758938|26098515|27052334|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 11-394 7.67e-63

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 206.31  E-value: 7.67e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  11 IQLRQLVRFVTITLGSSIFPFMAMYYTTYFG--TFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWF 88
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGlsASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  89 LTILANlpnaaIPWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLAL 168
Cdd:cd17329   81 LLGFAH-----SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 169 LVALLLVNVLCFGVAYYYFDETRPETHAfdhgKGLLASFQNYRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLKlyf 248
Cdd:cd17329  156 FLAAAVLFLLAALVLLFLLPETRPKRRA----AEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVV--- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 249 qptavlGFQVTSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFG 328
Cdd:cd17329  229 ------EILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLG 302

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489081430 329 EMINVPASQVLRADMMDHSQIGSYTGFVSMAQPLGAILASLLVSVSHFTGPLGVqcLFVVIALLGI 394
Cdd:cd17329  303 EMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGL--PWLILAALGL 366
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 11-394 7.67e-63

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 206.31  E-value: 7.67e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  11 IQLRQLVRFVTITLGSSIFPFMAMYYTTYFG--TFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWF 88
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGlsASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  89 LTILANlpnaaIPWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLAL 168
Cdd:cd17329   81 LLGFAH-----SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 169 LVALLLVNVLCFGVAYYYFDETRPETHAfdhgKGLLASFQNYRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLKlyf 248
Cdd:cd17329  156 FLAAAVLFLLAALVLLFLLPETRPKRRA----AEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVV--- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 249 qptavlGFQVTSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFG 328
Cdd:cd17329  229 ------EILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLG 302

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489081430 329 EMINVPASQVLRADMMDHSQIGSYTGFVSMAQPLGAILASLLVSVSHFTGPLGVqcLFVVIALLGI 394
Cdd:cd17329  303 EMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGL--PWLILAALGL 366
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
15-367 1.07e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 95.04  E-value: 1.07e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  15 QLVRFVTITLGSSIFPFMAMYYTtyFGTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILAn 94
Cdd:COG2814   19 AFLSGLGIGIVLPALPLIAADLG--ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  95 lPNaaiPWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDH-HFLALLVALL 173
Cdd:COG2814   96 -PS---LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 174 LVNVLCFGVAYYYFDETRPETHAfdhgkgllASFQNYRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLklyfqpTAV 253
Cdd:COG2814  172 VLALLALLLLLRLLPESRPAARA--------RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL------QEV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 254 LGFqvtSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINV 333
Cdd:COG2814  238 LGL---SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314

                        330       340       350
                 ....*....|....*....|....*....|....
gi 489081430 334 PASQVLRADMMDHSQIGSYTGFVSMAQPLGAILA 367
Cdd:COG2814  315 PLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_1 pfam07690
Major Facilitator Superfamily;
16-368 5.79e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 81.31  E-value: 5.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430   16 LVRFVTITLGSSIFPFMAMYYTTYFGT--FWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILA 93
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGIspTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430   94 nlpnAAIPWLTFAGILLVeIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLALLVALL 173
Cdd:pfam07690  83 ----SSLWLLLVLRVLQG-LGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  174 LVNVLCFGVAYYYFDETRPETHAFDHGKGLLASFQNYRQVFQDRAFVLFTLGAIFsGSIWMQMDNYVPVHLKlyfqptaV 253
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLF-GFAFFGLLTYLPLYQE-------V 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  254 LGFQVTSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINV 333
Cdd:pfam07690 230 LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVF 309

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 489081430  334 PASQVLRADMMDHSQIGSYTGFVSMAQPLGAILAS 368
Cdd:pfam07690 310 PALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
28-366 1.02e-03

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 41.20  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  28 IFPFMAMYYTTYFGtfWTGLLMMIT-SLMGFVGT---LYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANlpnaaIPWL 103
Cdd:PRK11646  29 VFPLISIRFVDQLG--WAAVMVGIAlGLRQFIQQglgIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAH-----EPWL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 104 TFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLALLVALLLVNVLCFGVA 183
Cdd:PRK11646 102 LWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLAAAFN 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 184 YYYFDETRPETHAFDHGKGLlasfqnyRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLK-LYFQPTAVlgfqvtssk 262
Cdd:PRK11646 182 AWLLPAYKLSTVRTPVREGM-------TRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNdIAGSPSAV--------- 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 263 mlSLMVLTNTLLIVLFMTVVNKLTEK-WKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQVLRA 341
Cdd:PRK11646 246 --KWMYAIEACLSLTLLYPIARWSEKrFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARETLSA 323

                        330       340
                 ....*....|....*....|....*
gi 489081430 342 DMMDHSQIGSYTGFVSMAQPLGAIL 366
Cdd:PRK11646 324 SLADARARGSYMGFSRLGLALGGAI 348
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 11-394 7.67e-63

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 206.31  E-value: 7.67e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  11 IQLRQLVRFVTITLGSSIFPFMAMYYTTYFG--TFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWF 88
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGlsASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  89 LTILANlpnaaIPWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLAL 168
Cdd:cd17329   81 LLGFAH-----SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 169 LVALLLVNVLCFGVAYYYFDETRPETHAfdhgKGLLASFQNYRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLKlyf 248
Cdd:cd17329  156 FLAAAVLFLLAALVLLFLLPETRPKRRA----AEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVV--- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 249 qptavlGFQVTSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFG 328
Cdd:cd17329  229 ------EILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLG 302

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489081430 329 EMINVPASQVLRADMMDHSQIGSYTGFVSMAQPLGAILASLLVSVSHFTGPLGVqcLFVVIALLGI 394
Cdd:cd17329  303 EMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGL--PWLILAALGL 366
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
15-367 1.07e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 95.04  E-value: 1.07e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  15 QLVRFVTITLGSSIFPFMAMYYTtyFGTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILAn 94
Cdd:COG2814   19 AFLSGLGIGIVLPALPLIAADLG--ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  95 lPNaaiPWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDH-HFLALLVALL 173
Cdd:COG2814   96 -PS---LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 174 LVNVLCFGVAYYYFDETRPETHAfdhgkgllASFQNYRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLklyfqpTAV 253
Cdd:COG2814  172 VLALLALLLLLRLLPESRPAARA--------RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL------QEV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 254 LGFqvtSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINV 333
Cdd:COG2814  238 LGL---SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314

                        330       340       350
                 ....*....|....*....|....*....|....
gi 489081430 334 PASQVLRADMMDHSQIGSYTGFVSMAQPLGAILA 367
Cdd:COG2814  315 PLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 19-404 3.18e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 91.48  E-value: 3.18e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  19 FVTITLGSSIFPFMAMYYTTY-FGTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANlpn 97
Cdd:cd17325    6 FLDMLGYGIIIPILPLYAESLgASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT--- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  98 aaIPWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHH-FLALLVALLLVN 176
Cdd:cd17325   83 --SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALgYRAPFLVCAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 177 VLCFGVAYYYFDETRPETHAFDHGKGLLASFqnYRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLklyfqpTAVLGF 256
Cdd:cd17325  161 LLALVLALLLLPEPRPPPNKRAVSAARLRSG--LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYA------AELGGL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 257 qvtSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPAS 336
Cdd:cd17325  233 ---SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489081430 337 QVLRADMMDHSQIGSYTGFVSMAQPLGAILASLLVSVshFTGPLGVQCLFVVIALLGIYFTVVSAKMK 404
Cdd:cd17325  310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF--LYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_1 pfam07690
Major Facilitator Superfamily;
16-368 5.79e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 81.31  E-value: 5.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430   16 LVRFVTITLGSSIFPFMAMYYTTYFGT--FWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILA 93
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGIspTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430   94 nlpnAAIPWLTFAGILLVeIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLALLVALL 173
Cdd:pfam07690  83 ----SSLWLLLVLRVLQG-LGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  174 LVNVLCFGVAYYYFDETRPETHAFDHGKGLLASFQNYRQVFQDRAFVLFTLGAIFsGSIWMQMDNYVPVHLKlyfqptaV 253
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLF-GFAFFGLLTYLPLYQE-------V 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  254 LGFQVTSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINV 333
Cdd:pfam07690 230 LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVF 309

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 489081430  334 PASQVLRADMMDHSQIGSYTGFVSMAQPLGAILAS 368
Cdd:pfam07690 310 PALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
9-371 2.40e-16

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 80.33  E-value: 2.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430   9 KQIQLRQLVRFVTITLGSSIF-----PFMAMYYTTYFG--TFWTGLLMMITSLMGFVGTLYGGHLSDALG-----RKKVI 76
Cdd:COG2211    5 KKLSLKEKLAYGLGDLGLNLAfgllsAYLLYFYTDVLGlsAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  77 MIGSVGTTLGWFLT-ILANLPNAAIPWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRR-FVYTINYWFINIAVMFGA 154
Cdd:COG2211   85 LIGAIPLALSFVLLfTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERtRLSSWRFAFAGLGGLLAS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 155 GLSGLFYDH-------HFLALLVALLLVNVLCFGVAYYYFDETRPETHAfdhgkgLLASFQNYRQVFQDRAFVLFTLGAI 227
Cdd:COG2211  165 VLPPPLVAAfggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE------KVSLKESLKALLKNRPFLLLLLAYL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 228 FSGSIWMQMDNYVPVHLKLYFQptavlgfqvTSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGML 307
Cdd:COG2211  239 LFFLALALVAALLLYYFKYVLG---------LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489081430 308 LAFTF--TQFYAIWLSVVLLTFGEMINVPASQVLRADMMDHSQI-------GSYTGFVSMAQPLGAILASLLV 371
Cdd:COG2211  310 LLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALA 382
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 16-398 9.88e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 75.16  E-value: 9.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  16 LVRFVTITLGSSIFPFMAMYYTTY-FGTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILAN 94
Cdd:cd06174    3 LGFFLTGLARGLISPLLPALLQSFgLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  95 LPnaaipWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHH---FLALLVA 171
Cdd:cd06174   83 SF-----WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfgWRAVFLI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 172 LLLVNVLCFGVAYYYFDETRPETHAFDHGKGLLASFQNYRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLKLYFQPT 251
Cdd:cd06174  158 AAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 252 AVlgfqvTSSKMLSLMVLTNTLLIVLFMTVVNKlteKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMI 331
Cdd:cd06174  238 VA-----VAGLLLSLFGLAGALGSLLLGLLSDR---LIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGG 309

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489081430 332 NVPASQVLRADMMDHSQIGSYTGFVSMAQPLGAILASLLVSVSHFTGPLGVQCLFVVIALLGIYFTV 398
Cdd:cd06174  310 LLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 24-403 5.00e-10

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 60.71  E-value: 5.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  24 LGSSIFPFMAMYYTTYFGT--FWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANLPNAAIP 101
Cdd:cd06173   13 LGDWIFTVALPWLVLQLTGsaLLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 102 WLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLALLVALLLVNVLCFG 181
Cdd:cd06173   93 WLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSA 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 182 VAYYY----FDETRPETHAFDHGKGLLASFQNYRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLKLyfqptavlgfq 257
Cdd:cd06173  173 LLLLFirrpPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG----------- 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 258 vtSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQ 337
Cdd:cd06173  242 --GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 338 VLRADMMDHSQIGS----YTGFVSMAQPLGAILASLLVSVshftgpLGVQCLFVVIALLGIYFTVVSAKM 403
Cdd:cd06173  320 TLLQLRVPDELRGRvfsvYNALNSGAMPLGALLAGLLADA------LGLSAVFLLAGALLLLAALLLLLL 383
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
19-163 1.84e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.06  E-value: 1.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  19 FVTITLGSSIFPFMAMYYTTYF---GTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANL 95
Cdd:COG2211  237 YLLFFLALALVAALLLYYFKYVlglSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGP 316

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489081430  96 PNaaiPWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRR-------FVYTINYWFINIAVMFGAGLSGLFYDH 163
Cdd:COG2211  317 GN---LWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGLLLAL 388
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
45-397 2.58e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 55.27  E-value: 2.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  45 TGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILAnlpNAAIPWLTFAGILLVEIASSFYGPAyeA 124
Cdd:COG2223   42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA---VSYWLLLLLGLLLGIGGGGSFAVGI--A 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 125 MLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLALLVALLLVNVLCFGVAYYYFDETRPETHAFDHGkgll 204
Cdd:COG2223  117 LVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK---- 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 205 ASFQNYRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLKLYFQPTAvlgfqVTSSKMLSLMVLTNTLLIVLFMTVVNK 284
Cdd:COG2223  193 ASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA-----ATAGLLAALFALLGALGRPLGGWLSDR 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 285 LTEKWKLLpqLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQVLrADMMDHSQIGSYTGFVSMAQPLGA 364
Cdd:COG2223  268 IGGRRVLL--IVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV-PDIFPTKNAGAVYGLVGAAGGLGG 344

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 489081430 365 ILASLLVSVSH-----FTGPLGVQCLFVVIALLGIYFT 397
Cdd:COG2223  345 FLGPLLFGALLdatgsYTAAFLVFAVLALVALVLTLLL 382
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 46-398 2.32e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.21  E-value: 2.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  46 GLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILAnlpnAAIPWLtFAGILLVEIASSFYGPAYEAM 125
Cdd:cd17489   34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA----TSVALL-LVLRLIHGIGWGAFTTAAATL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 126 LIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDH-----HFLALLVALLLVNVLCFGVayyyfdetrpETHAFDHG 200
Cdd:cd17489  109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHlgfavLFIVAAVLALLALLLVFLV----------KDPPPVAA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 201 KGLLASFQNYRQVFQDRAFvLFTLGAIFSGSIWMQMDNYVPVHLKLYFQPTAVLGFQVtsskmlslmvltNTLLIVLFMT 280
Cdd:cd17489  179 EEAEAGTRAFRRLVEKKVL-PPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTV------------YAIALLLSRP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 281 VVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQVLRADMMDHSQIGS----YTGFV 356
Cdd:cd17489  246 FSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAangtFFIFF 325

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 489081430 357 SMAQPLGAILASLLVSVSHFTGPLGVQCLFVVIALLGIYFTV 398
Cdd:cd17489  326 DLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 9-163 4.53e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 51.40  E-value: 4.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430   9 KQIQLRQLVRFVTITLGSSIFPFMAMYYT--TYFGTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLG 86
Cdd:cd17324  198 PRLRLAYLITFLLFGGFFALYTYLAPFLTdvPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489081430  87 WFLTILANLpnaaiPWLTFAGILLVEIASSFYGPAYEAMLIDLTDEsNRRFVYTINYWFINIAVMFGAGLSGLFYDH 163
Cdd:cd17324  278 LLLTLLGPS-----PLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-ARGLASSLYLAAYNLGGALGAALGGLVLDH 348
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 58-396 6.74e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 51.04  E-value: 6.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  58 VGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANlpnaAIPWLTFAGILLVEIASSFYGPAYeAMLIDLTDESNRRF 137
Cdd:cd17320   49 LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALAS----SIEQLLIARFLQGLGAAAGSVVAR-AIVRDLYSGAELAK 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 138 VYTinywFINIAVMFG-------AGLSGLFYDHHflALLVALLLVNVLCFGVAYYYFDETRPETHAfdhGKGLLASFQNY 210
Cdd:cd17320  124 IFS----LLMMILAIApalapllGGLLLLFFGWR--AIFVFLALLGLLLLLLVLLFLPETLPEEKR---KPLLSSLLRAY 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 211 RQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVhlkLYFQptaVLGFqvtSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWK 290
Cdd:cd17320  195 KRVLKNRRFLGYALALGLSFAGLFAYLAAAPF---IYIE---QLGL---SPAQFGLLFALNAIALILGSLLNGRLVRRFG 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 291 LLPQLVVGSLLFTLG--MLLAFTFTQFYAIWLSVVLLT---FGEMINVPASQVLRADMMDHsQIGSYTGFVSMAQPLGAI 365
Cdd:cd17320  266 PRRLLRLGLLLLLAAalVLLLAALLGGLSLWPLVAPLFlifFGFGLIFPNATSLALEPFPH-VAGTASALLGFLQFLIGA 344

                        330       340       350
                 ....*....|....*....|....*....|...
gi 489081430 366 LASLLVSVSHFTG--PLGVQCLFVVIALLGIYF 396
Cdd:cd17320  345 LAGALVGLLPNGTalPMGLLILVLGLLALLLLI 377
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 16-397 1.05e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 50.26  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  16 LVRFVTITLGSSIFPFMAMYYTTyfGTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANl 95
Cdd:cd17474    9 LLAVLGVSIVDPILPAIAEALGA--SPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSD- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  96 pnaAIPWLtFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLALLVALLLV 175
Cdd:cd17474   86 ---SFALL-LAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 176 NVLCFGVAYYYFDETRPETHAFDHGKGLLASFqnyrqVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLKLYFQPTAVlg 255
Cdd:cd17474  162 IPVAFLAILFLLPEPKEKAKSSSATKLRDLKK-----ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPI-- 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 256 fqvtsskMLSLMVLTNTLLIVLFMTVVNKLTEK-WKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVP 334
Cdd:cd17474  235 -------IIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLP 307

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489081430 335 ASQVLRADMMDHSQIGSYTGFVSMA----QPLGAILASLLVSVSHFTGPLGVQCLFVVIALLGIYFT 397
Cdd:cd17474  308 LLTTLVTELAPEEERGTASSLYNFVrflgQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 44-396 1.46e-06

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 49.93  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  44 WTGLLMMITSLMGFVGTLYGGHLSDAL----GRKK-VIMIGSVGTTLG--------WFLTILANLPNAAIPWLTFAGILL 110
Cdd:cd17313   35 LIGFVWTLGPILGLFVQPLVGSLSDRCnsriGRRRpFILVGAPLAALGlilipnaaDIGLALGDGPRTWALVLFVLGIVL 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 111 VEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLALLVALLL---------VNVLCFG 181
Cdd:cd17313  115 LDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFGFALGGNLkvpfyigaiILLVCVL 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 182 VAYYYFDETRPETHAFDHG--KGLLASFQNYRQVFQDRAFVLFTL-GAIFSGSI-WMQMDNYVPVHLKLYFQPTAVLGFQ 257
Cdd:cd17313  195 VTLFFVKEPPLSPEAGEHSenPSLGEVLKSLLKLLKIMPRSLLRLlLVIFFWWIaFFPFELFFTDYMGEEVYHGTSAASS 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 258 V--TSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPA 335
Cdd:cd17313  275 HygAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININ 354

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489081430 336 SQVLRADMMDHSQ--IGSYTGFVSMAQPLGAILASLLVSVSHFTGPLGVQCLFV----VIALLGIYF 396
Cdd:cd17313  355 PYPLVSDYHSESGrgQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAavasFLSLVGALF 421
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 28-404 5.27e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 47.98  E-value: 5.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  28 IFPFMAMYYTTYFGT--FWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANlpnaAIPWLTF 105
Cdd:cd17472   15 VLPVLSVYAKSLPGAtpTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYAT----SIYGLIL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 106 AGILLveiASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDH-HFLALLVALLLVNVLCFGVAY 184
Cdd:cd17472   91 GRALQ---GSGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHlGVSGLFLITAILSLVSLLILL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 185 YYFDETRPETHAFDHGKGLLasfqnyRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLKLYFQPTAVLGFQVTSSKML 264
Cdd:cd17472  168 FFVPDPPKIVQISEKEKKKL------KKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 265 SLmvltntLLIVLFMTVVNKLTEKWKLlpqLVVGSLLFTLGML-LAFTFTQFYAIWLSVVLLTFGEMINVPASQVLRADM 343
Cdd:cd17472  242 GF------ILMVPFVIYAEKKGKMKQV---FVSSILLIAVGFLlLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKI 312

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489081430 344 MDHSQIGSYTGFVSMAQPLGAILASLLvsVSHFTGPLGVQCLFVVIALLGIYFTVVSAKMK 404
Cdd:cd17472  313 APKEYRGTAMGIYNTSQFLGSFLGGAL--GGLLWGLLGYSSVFLTILILALLWLLVSFLLP 371
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
19-406 7.38e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.54  E-value: 7.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  19 FVTITLGSSIfPFMAMYYTtyFGTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILanlpnA 98
Cdd:COG0738   22 FATALWGPLI-PALKDAFG--LSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL-----A 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  99 AIPWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFiNIAVMFGAGLSGLFYDHHFLALLVALLLVNVL 178
Cdd:COG0738   94 PSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFF-SLGALLGPLLGGLLILLGLSLSWHLPYLILAV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 179 CFGVAYYYFDETR-PETHAFDHGKGllASFQNYRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLKLYFQptavlgfq 257
Cdd:COG0738  173 LLLLLALLFLRSKlPEIEEEEEEAA--GSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLG-------- 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 258 vTSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQ 337
Cdd:COG0738  243 -LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIF 321

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489081430 338 VLRADMMDHSQIGSYTGFVSMAQPLGAILASLLVSVSHFTGPLGVqclFVVIALLGIYFTVVSAKMKKV 406
Cdd:COG0738  322 SLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAA---FLVPLVCYLLILLLALALKRK 387
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 31-163 8.77e-06

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 47.57  E-value: 8.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  31 FMAMYYTTYFGTFWTGLLMMITSLMGFVGTLYGGHLSD-ALGRKKVIMIGSVGTTLGWFLTILAnlpnAAIPWLTFAGIL 109
Cdd:cd17346   28 YLTAQLGDGFSEADAASIYGAYTALVYLTPIIGGWLADkVLGARRTVFIGGILMALGYLLLALS----PFSVSMLYLGLA 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489081430 110 LVEIASSFYGPAYEAMLIDLTDESNRRF--VYTINYWFINIAVMFGAGLSGLFYDH 163
Cdd:cd17346  104 LIIVGNGLFKPNISSLVGKLYDENDPRRdsGFSIFYMGINLGAFLAPLLCGTLGDN 159
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
46-402 3.60e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 45.63  E-value: 3.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  46 GLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANLpnaaiPWLTFAGILLVEIASSFYGPAYEAM 125
Cdd:COG2271   48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATS-----FWQLLLLRFLLGLGEAGFFPAALKL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 126 LIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLALLVALLLVNVLCFGVAyyyfdetrpethafdhgkglla 205
Cdd:COG2271  123 IAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL---------------------- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 206 sfqnyrqvfqdrAFVLFTLGAIFSGSIWMQMDNYVPVHLKlyfqptAVLGF-QVTSSKMLSLMVLTNTLLIVLFMTVVNK 284
Cdd:COG2271  181 ------------RFWLLALAYFLVYFALYGFLTWLPTYLV------EVRGLsLAQAGLLLSLPFLAGIVGSLLGGWLSDR 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 285 LTEKWKLLpqLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQVLRADMMDHSQIGSYTGFVSMAQPLGA 364
Cdd:COG2271  243 LGRRRKLV--LAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGG 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 489081430 365 ILASLLV----SVSHFTGPLGVQCLFVVIALLGIYFTVVSAK 402
Cdd:COG2271  321 ALGPLLVgyllDATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 46-392 8.24e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.46  E-value: 8.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  46 GLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANlpnaAIPWLTFAGILLVeIASSFYGPAYEAM 125
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP----SFALLLLARALAG-LAHGGFWAIAAAY 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 126 LIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDH-HFLALLVALLLVNVLCFGVAYYYFDETRPEThafdhgKGLL 204
Cdd:cd17324  112 AADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLLPSLPPKK------PGSL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 205 ASFQNYRQVFQDRA-FVLFTLGAIFSGSIWMQMdNYVPVHLklyfqpTAVLGFqvtSSKMLSLMVLTNTLLIVLFMTVVN 283
Cdd:cd17324  186 GLLSSLLLLLRNPRlRLAYLITFLLFGGFFALY-TYLAPFL------TDVPGF---SSSAIIGLLLLFGVAGVVGSPLAG 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 284 KLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQ--VLRADMMDHSQIGS-YTGFVSMAQ 360
Cdd:cd17324  256 RLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQtrVLRLAPEARGLASSlYLAAYNLGG 335

                        330       340       350
                 ....*....|....*....|....*....|..
gi 489081430 361 PLGAILASLLVSVSHFTGPLGVQCLFVVIALL 392
Cdd:cd17324  336 ALGAALGGLVLDHGGWAGVGWVGAALLLLALL 367
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 26-110 1.03e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.08  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  26 SSIFPFMAMYYTTYFGTFWT-GLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANLPnAAIPWLT 104
Cdd:cd17478  212 SSLTTFLPFYLVQRGYSLVFaGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGI-WSYILLV 290


                 ....*.
gi 489081430 105 FAGILL 110
Cdd:cd17478  291 LAGFLL 296
MFS_1 pfam07690
Major Facilitator Superfamily;
260-406 1.03e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  260 SSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQVL 339
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALAL 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489081430  340 RADMMDHSQIGSYTGFVSMAQPLGAI----LASLLVSVSHFTGPLGVQCLFVVIALLGIYFTVVSAKMKKV 406
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAAlgplLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP 180
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 19-398 1.10e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.08  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  19 FVTITLGSSIFPFMAMYYTTYFGTFWT-GLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGwfLTILANLPN 97
Cdd:cd17478    6 FLNDFYQGFLPALLPLLIAKLGLSYAQaGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLG--LSLLGFAPN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  98 aaiPWLTFAGILLVEIASSFYGPAyEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLALLVALLLVNV 177
Cdd:cd17478   84 ---YWLLLLLVALAGIGSAAFHPE-GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 178 LCFGVAYYYFDETRPETHAFDHGKGLLASfqnyRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLKLYFQPTAVLGFq 257
Cdd:cd17478  160 LAVALLLLRLRPLKKPEAKKAAAKSSARS----TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGL- 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 258 vtsskMLSLMVLTNTLLIVLFMTVVNKLTEKWkllpqLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQ 337
Cdd:cd17478  235 -----LLSLFLFAGAIGTLIGGPLSDRFGRRR-----VIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV 304

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489081430 338 VLRADMMdhsqiGSYTGFVS-----MAQPLGAILASLLVSVSHFTGPLGVQCLFVVIALLGIYFTV 398
Cdd:cd17478  305 VLAQELL-----PGNVGLASglmmgLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 16-164 1.38e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 43.72  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  16 LVRFVTITLGSSIFPFMAMYYTTYFG----TFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTI 91
Cdd:cd17330    3 LVVFLDALGFGIVFPVLPFYVREFNKlgasGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489081430  92 LANLPNAAIPWLTFAGILLVEIASSFygpayeAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHH 164
Cdd:cd17330   83 LSRNLWLLFLARFLDGLTGGNVSVAQ------AYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPY 149
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
16-163 1.75e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.33  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  16 LVRFVTITLGSSIFPFMAMYYTTYFGTFWT--GLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILA 93
Cdd:COG2223  212 LLYFGTFGSFIGFSSWLPPYLVDQFGLSAAtaGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA 291

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  94 NLPnaaiPWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDH 163
Cdd:COG2223  292 LGS----LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 44-120 2.42e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 43.06  E-value: 2.42e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489081430  44 WTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANLPNAAIPWLTFAGILLVEIASSFYGP 120
Cdd:cd17371  246 GSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGA 322
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 19-122 3.73e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.20  E-value: 3.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  19 FVTITLGSSIFPFMAMYYTTYFGTF------WTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLgwFLTIL 92
Cdd:cd17316  183 ILLWFFISFGYYGLTTFLPTYLQTVlglspaTSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI--LALPL 260

                         90       100       110
                 ....*....|....*....|....*....|
gi 489081430  93 ANLPNAAIPWLTFAGILLVEIASSFYGPAY 122
Cdd:cd17316  261 FYLLSGSPTLLLLLLFILSFFVGGVWGALY 290
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
259-398 4.25e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.27  E-value: 4.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 259 TSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQV 338
Cdd:COG2814   42 ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALA 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489081430 339 LRADMMDHSQIGSYTGFVSMAQPLGAI----LASLLVSVSHFTGPLGVQCLFVVIALLGIYFTV 398
Cdd:COG2814  122 LIADLVPPERRGRALGLLGAGLGLGPAlgplLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL 185
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
63-164 4.51e-04

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 42.11  E-value: 4.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  63 GGHLSDA-LGRKKVIMIGSVGTTLGWFLtiLAnLPNAAipWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRF--VY 139
Cdd:COG3104   75 GGWLADRlLGQRRAILLGGILMALGHFL--LA-LPGGV--TLFYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRdaGF 149

                         90       100
                 ....*....|....*....|....*
gi 489081430 140 TINYWFINIAVMFGAGLSGLFYDHH 164
Cdd:COG3104  150 TIFYMGINIGAFLAPLLCGYLGEKY 174
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 44-397 4.61e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 42.24  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  44 WTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWflTILANLPNAaipWLTFAGILLVEI--ASSFYGPA 121
Cdd:cd17388   39 HYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDY--LLMAFAPTL---WWLYLGRIIAGItgATGAVAAA 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 122 YEAmliDLTDESNRrfvyTINYWFINIAvmFGAG------LSGLFYDHHFLALLVALLLVNVLCFGVAYYYFDETRPETH 195
Cdd:cd17388  114 YIA---DVTPPEQR----ARNFGLLGAA--FGLGfiagpaLGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPER 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 196 AFDHGKGLLASFQNYRQVFQDRA-------FVLFTLGAIFSGSIWMQMDNYvpvhlKLYFQPTAVlGFqvtsskmlSLMV 268
Cdd:cd17388  185 RRAFRWRRANPFGSLRWLTGFPGllgllavFFLIQLIGQVPATTWVLFTED-----RFDWSPTMV-GL--------SLAV 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 269 LtnTLLIVLFMT-VVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEmINVPASQVLRADMMDHS 347
Cdd:cd17388  251 F--GLLHALFQAfVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGG-IAGPALQGLLSRQVPEN 327

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489081430 348 QIGSYTGFVSMAQPLGAILASLLVSVSHFTGPLG-------VQCLFVVIALLGIYFT 397
Cdd:cd17388  328 EQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATwpglawiIGAALYLICLVLAYRF 384
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 4-120 5.33e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 41.74  E-value: 5.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430   4 FLNLPKQIQLRQLVRFVTITLGSSIFPFMAMYYTTYFG-TFWTGLL-MMITSLMGFVGTLYGGHLSDALGRKKVIMIGSV 81
Cdd:cd17369  223 LRRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGvDRSTVLLaVLIASVVAAITIPLFGWLSDRVGRRPVYLAGAL 302

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 489081430  82 GTTLgWFLTILANLPNAAIPWLTFAGILLVEIA-SSFYGP 120
Cdd:cd17369  303 LAAL-FAFPFFWLLDTGSTWLIVLAAVVVLGVLhGMMYGP 341
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
28-366 1.02e-03

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 41.20  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  28 IFPFMAMYYTTYFGtfWTGLLMMIT-SLMGFVGT---LYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANlpnaaIPWL 103
Cdd:PRK11646  29 VFPLISIRFVDQLG--WAAVMVGIAlGLRQFIQQglgIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAH-----EPWL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 104 TFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHHFLALLVALLLVNVLCFGVA 183
Cdd:PRK11646 102 LWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLAAAFN 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 184 YYYFDETRPETHAFDHGKGLlasfqnyRQVFQDRAFVLFTLGAIFSGSIWMQMDNYVPVHLK-LYFQPTAVlgfqvtssk 262
Cdd:PRK11646 182 AWLLPAYKLSTVRTPVREGM-------TRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNdIAGSPSAV--------- 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 263 mlSLMVLTNTLLIVLFMTVVNKLTEK-WKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQVLRA 341
Cdd:PRK11646 246 --KWMYAIEACLSLTLLYPIARWSEKrFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARETLSA 323

                        330       340
                 ....*....|....*....|....*
gi 489081430 342 DMMDHSQIGSYTGFVSMAQPLGAIL 366
Cdd:PRK11646 324 SLADARARGSYMGFSRLGLALGGAI 348
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 40-163 1.15e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 40.56  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  40 FGTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILAnlPNaaiPWLTFAGILLVEIASSFYG 119
Cdd:COG0477   46 ASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PS---PELLIAARALQGIGAGGLM 120

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 489081430 120 PAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDH 163
Cdd:COG0477  121 PGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164
Sugar_tr pfam00083
Sugar (and other) transporter;
37-156 1.41e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 40.72  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430   37 TTYFGTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANLPNAaiPWLTFAGILLVEIASS 116
Cdd:pfam00083  40 SLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWS--VYQLIVGRVLVGIGVG 117

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 489081430  117 FYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGL 156
Cdd:pfam00083 118 GASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIF 157
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 256-371 2.09e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.86  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 256 FQVTSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPA 335
Cdd:cd17473   29 FVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTL 108

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489081430 336 SQVLRADMMDHSQIGSYTGFVSMAQPLGAILASLLV 371
Cdd:cd17473  109 ATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLG 144
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 22-164 2.53e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.83  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  22 ITLGSSIFPFMAMY-YTTYFGTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILANlpnaaI 100
Cdd:cd17370  212 FALGNFSFAFLILRaQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGS-----S 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489081430 101 PWLTFAGILLVEIASSFYGPAYEAMLIDLTDESNRRFVYTINYWFINIAVMFGAGLSGLFYDHH 164
Cdd:cd17370  287 LWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI 350
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 217-375 2.64e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.46  E-value: 2.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 217 RAFVLFTLGAIFSGSIWMQMDNYVPvhlkLYFQptAVLGFqvtSSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLV 296
Cdd:cd17321  168 RTFSGAVLAAFLLGAALGGLLFLLP----LYLQ--GVLGY---SPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 297 VGSLLFTLGMLLAFTFTQ---FYAIWLSVVLLTFGEMINVPASQVLRADMMDHSQIGSYTGFVSMAQPLG-----AILAS 368
Cdd:cd17321  239 AGLLLTAVGLLLLALLGAdssVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGgalgvALLGA 318


                 ....*..
gi 489081430 369 LLVSVSH 375
Cdd:cd17321  319 LLTAGLS 325
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 217-392 2.88e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 39.47  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 217 RAFVLFTLGAIFSGSIWMQMDNYVPvhlkLYFQptAVLGFQVTSSkmlSLMVLTNTLLIVLFMTVVNKLTEKWKLL-PQL 295
Cdd:cd17502  167 RTILLSSIFGFLFGGALFGLIYYLP----LYFQ--LVLGDSATKS---GVRLLPLIIGLVIGSIISGALISKTGRYkPLI 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 296 VVGSLLFTLGMLLAFTFTQFYAIWLSVV---LLTFGEMINVPASQVLRADMMDHSQIGSYTGFVSMAQPLGailASLLVS 372
Cdd:cd17502  238 VIGTILMSVGAGLLTTLTLDTSKWLLIGyliLLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLG---GTLGVA 314

                        170       180
                 ....*....|....*....|.
gi 489081430 373 VSH-FTGPLGVQCLFVVIALL 392
Cdd:cd17502  315 ITDvFLVALALAALAFLLSLF 335
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 213-378 3.86e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.10  E-value: 3.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 213 VFQDRAFVLFTLGAIFSGSIWMQMdnyvPVHLKLYFQptAVLGFQVTSSkmlSLMVLTNTLLIVLFMTVVNKLTEKWKLL 292
Cdd:cd17503  174 LFKDRNFTLGLLLSFLLGLGLFGA----MFLLPLYLQ--NVLGYSAFES---GLVLAPGGLASAILSPLVGRLLDKFGPR 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 293 PQLVVGSLLFTLGM-LLAFTFTQFYAIWLSVVLLTFG---EMINVPASQVLRADmMDHSQIGSYTGFVSMAQPLG----- 363
Cdd:cd17503  245 LLLLAGLLLLALGTlLLAFLTPDTSLWLIILPLFIRGlgmGLVFMPLNTLALNS-LPPEQIGDATALFNTIRQLGgsigt 323

                        170
                 ....*....|....*
gi 489081430 364 AILASLLVSVSHFTG 378
Cdd:cd17503  324 ALLATLLTNRTQFHH 338
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
260-400 4.65e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 38.70  E-value: 4.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430 260 SSKMLSLMVLTNTLLIVLFMTVVNKLTEKWKLLPQLVVGSLLFTLGMLLAFTFTQFYAIWLSVVLLTFGEMINVPASQVL 339
Cdd:COG2271   43 SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKL 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489081430 340 RADMMDHSQIGSYTGFVSMAQPLGAILASLLVSVshFTGPLGVQCLFVVIALLGIYFTVVS 400
Cdd:COG2271  123 IAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW--LLAAFGWRAAFLILGLPGLLLALLR 181
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 19-93 5.22e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 38.74  E-value: 5.22e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489081430  19 FVTITLGSSIFPFMAMYYTTYFGTFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWFLTILA 93
Cdd:cd17316   12 AYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL 86
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 22-125 6.93e-03

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 38.51  E-value: 6.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  22 ITLGSSIFPFMAMYYTTYFGTFWTGL-------LMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGWF--LTIL 92
Cdd:cd17368  230 LVAGSTVTFYFTTVYTPTYAKTVLGLsardsflVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYpvFAWL 309

                         90       100       110
                 ....*....|....*....|....*....|...
gi 489081430  93 ANLPNAAIpwLTFAGILLVEIASSFYGPAYEAM 125
Cdd:cd17368  310 TAAPSFGR--LLLVLLVLSFFFGMYGGAMVVAL 340
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 42-114 8.35e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 38.02  E-value: 8.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489081430  42 TFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGwfLTILANLPNaaiPWLTFAGILLVEIA 114
Cdd:cd17360   34 TGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIG--AIVMAAAPN---KEVLIVGRVLVGLG 101
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 16-121 9.12e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 37.92  E-value: 9.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081430  16 LVRFVTITLGSSIFPFMAMYYTTYFG--TFWTGLLMMITSLMGFVGTLYGGHLSDALGRKKVIMIGSVGTTLGwfLTILA 93
Cdd:cd17321  175 LAAFLLGAALGGLLFLLPLYLQGVLGysPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG--LLLLA 252

                         90       100
                 ....*....|....*....|....*...
gi 489081430  94 NLPNAAIPWLTFAGILLVEIASSFYGPA 121
Cdd:cd17321  253 LLGADSSVWLLLPGLVLLGLGLGLFATP 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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