NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489082212|ref|WP_002992136|]
View 

DUF1492 domain-containing protein [Streptococcus pyogenes]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF1492 super family cl06423
Protein of unknown function (DUF1492); This family consists of several hypothetical, highly ...
 64-113 2.79e-04

Protein of unknown function (DUF1492); This family consists of several hypothetical, highly conserved Streptococcal and related phage proteins of around 100 residues in length. The function of this family is unknown. It appears to be distantly related to pfam08281.


The actual alignment was detected with superfamily member pfam07374:

Pssm-ID: 311366  Cd Length: 100  Bit Score: 37.51  E-value: 2.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 489082212   64 MIATLQDERQIAVIKARYVDDLSWDEILDKLGYSRNTVFKLHREALEVLD 113
Cdd:pfam07374  51 MINNLENPDSRSVLRMVYIDKMTIWQVCDKLNISRTTYYRLLRVATKELN 100
 
Name Accession Description Interval E-value
DUF1492 pfam07374
Protein of unknown function (DUF1492); This family consists of several hypothetical, highly ...
 64-113 2.79e-04

Protein of unknown function (DUF1492); This family consists of several hypothetical, highly conserved Streptococcal and related phage proteins of around 100 residues in length. The function of this family is unknown. It appears to be distantly related to pfam08281.


Pssm-ID: 311366  Cd Length: 100  Bit Score: 37.51  E-value: 2.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 489082212   64 MIATLQDERQIAVIKARYVDDLSWDEILDKLGYSRNTVFKLHREALEVLD 113
Cdd:pfam07374  51 MINNLENPDSRSVLRMVYIDKMTIWQVCDKLNISRTTYYRLLRVATKELN 100
RpoE COG1595
DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; ...
 53-119 8.78e-03

DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; DNA-directed RNA polymerase specialized sigma subunit, sigma24 family is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 441203 [Multi-domain]  Cd Length: 181  Bit Score: 34.20  E-value: 8.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489082212  53 YLAKERDKRL-AMIATLqDERQIAVIKARYVDDLSWDEILDKLGYSRNTVFKLHREALEVLDEQEERY 119
Cdd:COG1595  112 LEAEELLEALlAALERL-PPRQREVLVLRYLEGLSYAEIAEILGISEGTVKSRLSRARKKLREALEEE 178
 
Name Accession Description Interval E-value
DUF1492 pfam07374
Protein of unknown function (DUF1492); This family consists of several hypothetical, highly ...
 64-113 2.79e-04

Protein of unknown function (DUF1492); This family consists of several hypothetical, highly conserved Streptococcal and related phage proteins of around 100 residues in length. The function of this family is unknown. It appears to be distantly related to pfam08281.


Pssm-ID: 311366  Cd Length: 100  Bit Score: 37.51  E-value: 2.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 489082212   64 MIATLQDERQIAVIKARYVDDLSWDEILDKLGYSRNTVFKLHREALEVLD 113
Cdd:pfam07374  51 MINNLENPDSRSVLRMVYIDKMTIWQVCDKLNISRTTYYRLLRVATKELN 100
Sigma70_r4 pfam04545
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
 70-112 3.64e-03

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif. Due to the way Pfam works, the threshold has been set artificially high to prevent overlaps with other helix-turn-helix families. Therefore there are many false negatives.


Pssm-ID: 461347 [Multi-domain]  Cd Length: 50  Bit Score: 33.17  E-value: 3.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 489082212   70 DERQIAVIKARYVDDLSWDEILDKLGYSRNTVFKLHREALEVL 112
Cdd:pfam04545   6 PPRERQVLVLRYGEGLTLEEIGERLGISRERVRQIEKRALRKL 48
RpoE COG1595
DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; ...
 53-119 8.78e-03

DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; DNA-directed RNA polymerase specialized sigma subunit, sigma24 family is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 441203 [Multi-domain]  Cd Length: 181  Bit Score: 34.20  E-value: 8.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489082212  53 YLAKERDKRL-AMIATLqDERQIAVIKARYVDDLSWDEILDKLGYSRNTVFKLHREALEVLDEQEERY 119
Cdd:COG1595  112 LEAEELLEALlAALERL-PPRQREVLVLRYLEGLSYAEIAEILGISEGTVKSRLSRARKKLREALEEE 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH