|
Name |
Accession |
Description |
Interval |
E-value |
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
2-319 |
0e+00 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 595.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 2 IKKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDEN 81
Cdd:PRK03202 1 MKRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 82 VRAVAIENLKKRGIDALVVIGGDGSYMGAKRLTEMGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSSH 161
Cdd:PRK03202 81 GRAKAIENLKKLGIDALVVIGGDGSYMGAKRLTEHGIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTASSH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 162 QRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEIKAGIAKGKKHAIVAITEHMCDVDELAHYIEKETGR 241
Cdd:PRK03202 161 ERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGKKHAIIVVAEGVMPAEELAKEIEERTGL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489118935 242 ETRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAGHGGRCVGIQNEQLVHHDIIDAIENMKRPFKGDWLDCAKKL 319
Cdd:PRK03202 241 ETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGRMVGIQNNKIVHVPIEEAVENMKHPFDKDLYELAKKL 318
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-320 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 562.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 3 KKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENV 82
Cdd:cd00763 1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 83 RAVAIENLKKRGIDALVVIGGDGSYMGAKRLTEMGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSSHQ 162
Cdd:cd00763 81 QAKAIEQLKKHGIDALVVIGGDGSYMGAMRLTEHGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSSSHQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 163 RISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEIKAGIAKGKKHAIVAITEHMCDVDELAHYIEKETGRE 242
Cdd:cd00763 161 RISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGKKHAIVVVAEGVYDVDELAKEIEEATGFE 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489118935 243 TRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAGHGGRCVGIQNEQLVHHDIIDAIENMKrPFKGDWLDCAKKLY 320
Cdd:cd00763 241 TRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGKGGLAVGIQNEQLVHHDIIDAIENMK-PFKKDWLALAKKLS 317
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
2-319 |
4.54e-165 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 463.01 E-value: 4.54e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 2 IKKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDEN 81
Cdd:COG0205 1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 82 VRAVAIENLKKRGIDALVVIGGDGSYMGAKRLTE-MGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSS 160
Cdd:COG0205 81 GREKALENLKKLGIDALVVIGGDGSLDGAAKLAEeYGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 161 HQRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEIKAGIAKGKKHAIVAITEHMCDVD----------- 229
Cdd:COG0205 161 HERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKLLEKLKERRKRGKGYSIIVVAEGAGDEDgeavleadtda 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 230 -----------ELAHYIEKETGRETRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAGHGGRCVGIQNEQLVHHDII 298
Cdd:COG0205 241 fghvrlggigeYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKTGVMVGIRRGEIVLVPLE 320
|
330 340
....*....|....*....|..
gi 489118935 299 DAIENMKR-PFKGDWLDCAKKL 319
Cdd:COG0205 321 EVANKEKPvDPDSPLIQLAREL 342
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
4-274 |
8.10e-154 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 431.38 E-value: 8.10e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 4 KIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENVR 83
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 84 AVAIENLKKRGIDALVVIGGDGSYMGAKRLT-EMGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSSHQ 162
Cdd:pfam00365 81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSeERGIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDTASSHN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 163 RISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEIKAGIaKGKKHAIVAITEHMCDVDELAHYIEKETGRE 242
Cdd:pfam00365 161 RVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELR-KGKRFSIIVVAEGASDGEFLAKLIEEGTGIE 239
|
250 260 270
....*....|....*....|....*....|..
gi 489118935 243 TRSTVLGHIQRGGSPVPYDRILASRMGAYAIE 274
Cdd:pfam00365 240 TRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
4-301 |
1.09e-141 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 402.11 E-value: 1.09e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 4 KIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENVR 83
Cdd:TIGR02482 1 KIGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLINGKIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 84 AVAIENLKKRGIDALVVIGGDGSYMGAKRLTEMG-FPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSSHQ 162
Cdd:TIGR02482 81 EKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEEGgIPVIGLPGTIDNDIPGTDYTIGFDTALNTIIDAVDKIRDTATSHE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 163 RISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEIKAGIAKGKKHAIVAITEHMC--DVDELAHYIEKETG 240
Cdd:TIGR02482 161 RAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDIDELIQRLKEQHEAGKKHSIIIVAEGNIvgSAKEVAKKIEEKTG 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489118935 241 RETRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAGHGGRCVGIQNEQLVHHDIIDAI 301
Cdd:TIGR02482 241 IETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGVMIGIQNNKIVTHPIEEAL 301
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
2-319 |
0e+00 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 595.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 2 IKKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDEN 81
Cdd:PRK03202 1 MKRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 82 VRAVAIENLKKRGIDALVVIGGDGSYMGAKRLTEMGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSSH 161
Cdd:PRK03202 81 GRAKAIENLKKLGIDALVVIGGDGSYMGAKRLTEHGIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTASSH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 162 QRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEIKAGIAKGKKHAIVAITEHMCDVDELAHYIEKETGR 241
Cdd:PRK03202 161 ERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGKKHAIIVVAEGVMPAEELAKEIEERTGL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489118935 242 ETRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAGHGGRCVGIQNEQLVHHDIIDAIENMKRPFKGDWLDCAKKL 319
Cdd:PRK03202 241 ETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGRMVGIQNNKIVHVPIEEAVENMKHPFDKDLYELAKKL 318
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-320 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 562.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 3 KKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENV 82
Cdd:cd00763 1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 83 RAVAIENLKKRGIDALVVIGGDGSYMGAKRLTEMGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSSHQ 162
Cdd:cd00763 81 QAKAIEQLKKHGIDALVVIGGDGSYMGAMRLTEHGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSSSHQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 163 RISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEIKAGIAKGKKHAIVAITEHMCDVDELAHYIEKETGRE 242
Cdd:cd00763 161 RISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGKKHAIVVVAEGVYDVDELAKEIEEATGFE 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489118935 243 TRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAGHGGRCVGIQNEQLVHHDIIDAIENMKrPFKGDWLDCAKKLY 320
Cdd:cd00763 241 TRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGKGGLAVGIQNEQLVHHDIIDAIENMK-PFKKDWLALAKKLS 317
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-318 |
1.21e-165 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 464.08 E-value: 1.21e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 3 KKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENV 82
Cdd:cd00363 1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 83 RAVAIENLKKRGIDALVVIGGDGSYMGAKRLTEM------GFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRD 156
Cdd:cd00363 81 RAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEwpskyqGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 157 TSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEF---SRDDLVAEIKAGIAKGKKHAIVAITEHMCD------ 227
Cdd:cd00363 161 TASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAadeWEEEMVDVIKKRRERGKRHGIVIVAEGAIDfipkpi 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 228 -VDELAHYIEKETGRETRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAGHGGRCVGIQNE---QLVHHDIIDAIEN 303
Cdd:cd00363 241 tEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGIQNLnenQVVRHPLTEAVNM 320
|
330
....*....|....*...
gi 489118935 304 MKR---PFKGDWLDCAKK 318
Cdd:cd00363 321 TKRvgvDLEGRPFKKFAK 338
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
2-319 |
4.54e-165 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 463.01 E-value: 4.54e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 2 IKKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDEN 81
Cdd:COG0205 1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 82 VRAVAIENLKKRGIDALVVIGGDGSYMGAKRLTE-MGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSS 160
Cdd:COG0205 81 GREKALENLKKLGIDALVVIGGDGSLDGAAKLAEeYGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 161 HQRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEIKAGIAKGKKHAIVAITEHMCDVD----------- 229
Cdd:COG0205 161 HERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKLLEKLKERRKRGKGYSIIVVAEGAGDEDgeavleadtda 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 230 -----------ELAHYIEKETGRETRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAGHGGRCVGIQNEQLVHHDII 298
Cdd:COG0205 241 fghvrlggigeYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKTGVMVGIRRGEIVLVPLE 320
|
330 340
....*....|....*....|..
gi 489118935 299 DAIENMKR-PFKGDWLDCAKKL 319
Cdd:COG0205 321 EVANKEKPvDPDSPLIQLAREL 342
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
4-274 |
8.10e-154 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 431.38 E-value: 8.10e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 4 KIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENVR 83
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 84 AVAIENLKKRGIDALVVIGGDGSYMGAKRLT-EMGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSSHQ 162
Cdd:pfam00365 81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSeERGIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDTASSHN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 163 RISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEIKAGIaKGKKHAIVAITEHMCDVDELAHYIEKETGRE 242
Cdd:pfam00365 161 RVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELR-KGKRFSIIVVAEGASDGEFLAKLIEEGTGIE 239
|
250 260 270
....*....|....*....|....*....|..
gi 489118935 243 TRSTVLGHIQRGGSPVPYDRILASRMGAYAIE 274
Cdd:pfam00365 240 TRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
4-301 |
1.09e-141 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 402.11 E-value: 1.09e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 4 KIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENVR 83
Cdd:TIGR02482 1 KIGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLINGKIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 84 AVAIENLKKRGIDALVVIGGDGSYMGAKRLTEMG-FPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSSHQ 162
Cdd:TIGR02482 81 EKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEEGgIPVIGLPGTIDNDIPGTDYTIGFDTALNTIIDAVDKIRDTATSHE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 163 RISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEIKAGIAKGKKHAIVAITEHMC--DVDELAHYIEKETG 240
Cdd:TIGR02482 161 RAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDIDELIQRLKEQHEAGKKHSIIIVAEGNIvgSAKEVAKKIEEKTG 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489118935 241 RETRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAGHGGRCVGIQNEQLVHHDIIDAI 301
Cdd:TIGR02482 241 IETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGVMIGIQNNKIVTHPIEEAL 301
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
3-279 |
7.52e-86 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 273.06 E-value: 7.52e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 3 KKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYE--DRMVQLDRYSVSDMINRGGTFLGSARFPEFRDE 80
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDggDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 81 NVRAVAIENLKKRGIDALVVIGGDGSYMGA-----------KRLTEMG------------FPCIGLPGTIDNDIKGTDYT 137
Cdd:TIGR02478 81 PGRLKAARNLVSNGIDALVVIGGDGSLTGAdlfreewpsllEELVDTGkitaeqaeehrhLTIVGLVGSIDNDMCGTDMT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 138 IGYFTALGTVVEAIDRLRDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEV---EFSRDDLVAEIKAGIAKGK 214
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERppeEGWEDQLCHKLKRNRKAGK 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489118935 215 KHAIVAITE-------HMCDVDELAHYIEKETGRETRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAG 279
Cdd:TIGR02478 241 RKTIVIVAEgaidrdlNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLES 312
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
2-302 |
3.79e-83 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 255.38 E-value: 3.79e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 2 IKKIGVLTSGGDAPGMNAAIRGVV-RAALTEGLEVMGIHDGYLGLYED--RMVQLDRYSVSDMINRGGTFLGSAR----- 73
Cdd:PRK14071 4 KKRIGILTSGGDCAGLNAVIRAVVhRARGTYGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNkgdpf 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 74 -FP----EFRDENvrAVAIENLKKRGIDALVVIGGDGSYMGAKRLTEMG-FPCIGLPGTIDNDIKGTDYTIGYFTALGTV 147
Cdd:PRK14071 84 aFPmpdgSLRDRS--QEIIDGYHSLGLDALIGIGGDGSLAILRRLAQQGgINLVGIPKTIDNDVGATEVSIGFDTAVNIA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 148 VEAIDRLRDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEIKAGIAKGKKHAIVAITEHMCD 227
Cdd:PRK14071 162 TEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTLENVCKKIRERQEEGKNFCLVVVSEAVRT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 228 VD--------------------ELAHYIEKETGRETRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAGHGGRCVGI 287
Cdd:PRK14071 242 EEgeqvtktqalgedryggigqYLAEQIAERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQGKFDRMVAW 321
|
330
....*....|....*
gi 489118935 288 QNEQLVHHDIIDAIE 302
Cdd:PRK14071 322 QNRQVVSVPIAEAIA 336
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-279 |
4.48e-75 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 245.12 E-value: 4.48e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 3 KKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYE--DRMVQLDRYSVSDMINRGGTFLGSARFPEFRDE 80
Cdd:cd00764 4 KAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKggDYIKQAEWESVSNWLQEGGTIIGSARCKEFRER 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 81 NVRAVAIENLKKRGIDALVVIGGDGSYMGAK-----------------RLTEMGFP------CIGLPGTIDNDIKGTDYT 137
Cdd:cd00764 84 EGRLQAAYNLIQRGITNLCVIGGDGSLTGADlfrsewpslleelvkdgKITEEEVAkyqhlnIVGMVGSIDNDFCGTDMT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 138 IGYFTALGTVVEAIDRLRDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSR---DDLVAEIKAGIAKGK 214
Cdd:cd00764 164 IGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDgweDQMCRRLSEHRSRGK 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489118935 215 KHAIVAITEHMCDVD-------ELAHYIEKETGRETRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAG 279
Cdd:cd00764 244 RLNIIIVAEGAIDDQlkpitseDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEA 315
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
3-296 |
2.33e-56 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 194.48 E-value: 2.33e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 3 KKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARfpEFRDENV 82
Cdd:TIGR02478 390 LRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNR--SLPGDDL 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 83 RAVAiENLKKRGIDALVVIGGDGSYMGAKRL-------TEMGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLR 155
Cdd:TIGR02478 468 GTIA-YYFQQHKIDGLIIIGGFEAFEALYQLdaarekyPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIK 546
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 156 DTSS-SHQRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDL---VAEIKAGIAKGKKHAIVAITEHMCDV--- 228
Cdd:TIGR02478 547 QSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLqedIEHLKETFAEGRAGKLILRNEKASKVytt 626
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 229 DELAHYIEKET-GR-ETRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAGHGGrcVGIQNEQLVHHD 296
Cdd:TIGR02478 627 DFIARIISEEGkGRfDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKA--NKHADKLSADDT 694
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
4-280 |
4.34e-46 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 166.15 E-value: 4.34e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 4 KIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENVR 83
Cdd:cd00764 391 NIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETI 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 84 AvaiENLKKRGIDALVVIGGDGSYMGAKRL-------TEMGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRD 156
Cdd:cd00764 471 A---YNFQKYGIDGLIIVGGFEAYKGLLQLreareqyEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQ 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 157 T-SSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEI-------KAGIAKGKKHAIVAITEHMCDV 228
Cdd:cd00764 548 SaSGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVehltekmKTTIGRGLVLRNEKCNENYTTV 627
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 489118935 229 DELAHYIEKETGR-ETRSTVLGHIQRGGSPVPYDRILASRMGAYAIELLLAGH 280
Cdd:cd00764 628 FTYELYSEEGKGVfDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKL 680
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
4-293 |
2.47e-38 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 141.33 E-value: 2.47e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 4 KIGVLTSGGDAPGMNAAIRGVVRAALTE-GLE-VMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDEN 81
Cdd:PTZ00286 89 KAGIVTCGGLCPGLNVVIRELVMNLINNyGVKtIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSRGGFDPKVM 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 82 VravaiENLKKRGIDALVVIGGDGSYMGAKRLTE----MGFPC--IGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLR 155
Cdd:PTZ00286 169 V-----DTLIRHGINILFTLGGDGTHRGALAIYKelrrRKLNIsvVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAY 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 156 DTSSSHQR-ISIVEVMGRYCGDLTLAAAIAGGCEFVV-VPEVEFSRDDLVAEIKAGIAKgKKHAIVAITEHMC------- 226
Cdd:PTZ00286 244 VEAKSAKNgVGIVKLMGRDSGFIALHASVASADVNVClIPEFDIPLEGVLEYIEQRLQK-KGHCVIVVAEGAGqslkdad 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 227 --------------DV-----DELAHYIEKETGRETrstvLGHIQ-----RGGSPVPYDRILASRMGAYAIELLLAGHGG 282
Cdd:PTZ00286 323 ldlgtdasgnkklwDIgvylkDEITKYLKKKKPEHT----VKYIDpsymiRAVPANAADAKFCTQLAQNAVHGAMAGFTG 398
|
330
....*....|.
gi 489118935 283 RCVGIQNEQLV 293
Cdd:PTZ00286 399 FIIGHVHNNYV 409
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
1-288 |
1.24e-29 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 116.88 E-value: 1.24e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 1 MIKKIGVLTSGGDAPGMNAAIRGVVRAAL--TEGLEVMGIHDGYLGLYEDRMVQLDRYSVSD---MINRGGTFLGSARFP 75
Cdd:PRK14072 2 MKGNALYAQSGGPTAVINASAAGVIEEARkhKKIGKVYGARNGIIGILDEDLIDLSKESDEAlaaLAHTPSGALGSCRYK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 76 EFRDENVRA---VAIENLKKRGIDALVVIGGDGSYMGAKRLTE----MGFP--CIGLPGTIDNDIKGTDYTIGY-----F 141
Cdd:PRK14072 82 LKSLEEDRAeyeRLLEVFKAHDIGYFFYNGGNDSMDTALKVSQlakkMGYPirCIGIPKTIDNDLPGTDHCPGFgsaakY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 142 TAlGTVVEAIdrlRDTSSSHQ--RISIVEVMGRYCGDLTLAAAIA-----GGCEFVVVPEVEFSRDDLVAEIKAGIAKGK 214
Cdd:PRK14072 162 IA-TSVLEAA---LDVAAMANtsKVFILEVMGRHAGWLAAAAALAkqnpdDAPHLIYLPERPFDEEKFLADVRAIVKRYG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 215 KHAIVA-----------ITEHMCDVDE------------LAHYIEKETGRETRSTVLGHIQRGG----SPVpyDRILASR 267
Cdd:PRK14072 238 YCVVVVsegirdadgkfIAEAGLAEDAfghaqlggvapvLANLIKEKLGKKVHWAVLDYLQRAArhiaSKT--DVEEAYA 315
|
330 340
....*....|....*....|.
gi 489118935 268 MGAYAIELLLAGHGGRCVGIQ 288
Cdd:PRK14072 316 VGKAAVEYALAGKNGVMPAIR 336
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
4-294 |
9.56e-28 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 111.88 E-value: 9.56e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 4 KIGVLTSGGDAPGMNAAIRGVVRAALTE-GL-EVMGIHDGYLGL---YEDRMVQLDRYSVSDMINRGGTFLGSARFPEFR 78
Cdd:PRK06830 82 KAAIVTCGGLCPGLNDVIRAIVLELHHHyGVrRILGIRYGYQGLiprYGHDPVELTPEVVADIHEFGGTILGSSRGPQDP 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 79 DENVRAvaienLKKRGIDALVVIGGDGSYMGAKRLTE------MGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAID 152
Cdd:PRK06830 162 EEIVDT-----LERMNINILFVIGGDGTLRGASAIAEeierrgLKISVIGIPKTIDNDINFIQKSFGFETAVEKATEAIR 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 153 rlrdtsSSHQR-------ISIVEVMGRYCGDLTLAAAIAGG-CEFVVVPEVEFSRDD---LVAEIKAGIAKgKKHAIVAI 221
Cdd:PRK06830 237 ------CAHVEangapngIGLVKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLEGpngLLAALEKRLAE-RGHAVIVV 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 222 TE----HMCDVDEL----AHYIEKETGRETRSTVLGHIQRGGSPV-----------------PYDRILASRMGAYAIELL 276
Cdd:PRK06830 310 AEgagqELFDDTGEtdasGNPKLGDIGLFLKDRIKEYFKARGIPInlkyidpsyiirsvpanANDSVYCGFLGQNAVHAA 389
|
330
....*....|....*...
gi 489118935 277 LAGHGGRCVGIQNEQLVH 294
Cdd:PRK06830 390 MAGKTGMVVGRWNNRFVH 407
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
4-306 |
4.41e-27 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 109.52 E-value: 4.41e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 4 KIGVLTSGGDAPGMNAAIRGVVRAALTEGLE-VMGIHDGYLGLYEDRM--VQLDRYSVSDMINRGGTFLGSARFPEFRDE 80
Cdd:PLN02884 55 KAAIVTCGGLCPGLNDVIRQIVFTLEIYGVKnIVGIPFGYRGFFEKGLseMPLSRKVVQNIHLSGGSLLGVSRGGAKTSD 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 81 NVravaiENLKKRGIDALVVIGGDGSYMGAK------RLTEMGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRL 154
Cdd:PLN02884 135 IV-----DSIEARGINMLFVLGGNGTHAGANaihnecRKRKMKVSVVGVPKTIDNDILLMDKTFGFDTAVEEAQRAINSA 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 155 R-DTSSSHQRISIVEVMGRYCGDLTLAAAIAGG-CEFVVVPEVEFSRD---DLVAEIKAGIAKgKKHAIVAITE------ 223
Cdd:PLN02884 210 YiEAHSAYHGIGLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDgpnGVLRHLEHLIET-KGSAVVCVAEgagqdl 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 224 --HMCDVDELAHYIEKETGRETRSTVLGHIQRGGSP--VPY---------------DRILASRMGAYAIELLLAGHGGRC 284
Cdd:PLN02884 289 lqKTNATDASGNPVLGDIGVHLQQEIKKHFKDIGVPadVKYidptymiracranasDAILCTVLGQNAVHGAFAGFSGIT 368
|
330 340
....*....|....*....|..
gi 489118935 285 VGIQNEQLVHHDIIDAIENMKR 306
Cdd:PLN02884 369 VGICNTHYVYLPIPEVIAYPRR 390
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
7-197 |
1.88e-24 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 102.90 E-value: 1.88e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 7 VLTSGGDAPGMNAAIRGVVRaalteGL-------EVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRD 79
Cdd:PLN02564 92 IVTCGGLCPGLNTVIREIVC-----GLsymygvtRILGIDGGYRGFYSRNTIPLTPKVVNDIHKRGGTILGTSRGGHDTS 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 80 ENVravaiENLKKRGIDALVVIGGDGSYMGAKRLTE----MGFPC--IGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDR 153
Cdd:PLN02564 167 KIV-----DSIQDRGINQVYIIGGDGTQKGASVIYEeirrRGLKVavAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINA 241
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 489118935 154 LR-DTSSSHQRISIVEVMGRYCGDLTLAAAIAG-GCEFVVVPEVEF 197
Cdd:PLN02564 242 AHvEAESVENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPF 287
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
2-223 |
2.57e-19 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 88.94 E-value: 2.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 2 IKKIGVLTSGGDAPGMNAAIRGVVRAA--LTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGG-TFLGSARfPEFR 78
Cdd:PTZ00287 177 VLKIGIILSGGPAPGGHNVISGIYDYAkrYNEQSQVIGFLGGIDGLYSKNYVTITDSLMNRFRNLGGfNMLWSGR-GKVR 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 79 DENvRAVAIENL-KKRGIDALVVIGGDGSYMGAKRLTE------MGFPCIGLPGTIDNDIK--GTDYTIGYFTALGTVVE 149
Cdd:PTZ00287 256 NKD-DLIAIENIvAKLKLNGLVIIGGDGSNSNAALISEyfaerqIPISIIGIPKTIDGDLKseAIEISFGFDTATKTYSE 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 150 AIDRL-RDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFVVV-PEVE---FSRDDLVAEIKAGIAK----GKKHAIVA 220
Cdd:PTZ00287 335 VIGNLcTDVKTGHNVYHVVRVMGRSASHVVLECALQTRPNIVLIgEEVEkenLSLKDIVSNIVNTILKrrslNKNYGVIL 414
|
...
gi 489118935 221 ITE 223
Cdd:PTZ00287 415 IPE 417
|
|
| PRK07085 |
PRK07085 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional |
3-223 |
3.13e-19 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
Pssm-ID: 235930 Cd Length: 555 Bit Score: 88.05 E-value: 3.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 3 KKIGVLTSGGDAPGMNAAIRGvvraaLTEGLEVM-------GIHDGYLGLYEDRMVQLDRYSVSDMINRGG-TFLGSARF 74
Cdd:PRK07085 71 LKVGVILSGGQAPGGHNVIAG-----LFDGLKKLnpdsklfGFIGGPLGLLNGKYIEITEEVIDEYRNTGGfDMIGSGRT 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 75 PEFRDENvRAVAIENLKKRGIDALVVIGGDGSYMGAKRLTE------MGFPCIGLPGTIDNDIKGT--DYTIGYFTALGT 146
Cdd:PRK07085 146 KIETEEQ-KEACLETVKKLKLDGLVIIGGDDSNTNAAILAEyfakhgCKTQVIGVPKTIDGDLKNEfiETSFGFDTATKT 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 147 VVEAIDRL-RDTSSSHQRISIVEVMGRYcgdltlAAAIAGGCEFVVVP-------EVE---FSRDDLVAEIKAGI----A 211
Cdd:PRK07085 225 YSEMIGNIsRDALSAKKYWHFIKLMGRS------ASHIALECALQTHPnicliseEVAekkMSLQDIVHYIASVIadraA 298
|
250
....*....|..
gi 489118935 212 KGKKHAIVAITE 223
Cdd:PRK07085 299 KGKNYGVILIPE 310
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
1-207 |
1.24e-16 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 79.67 E-value: 1.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 1 MIKKIGVLTSGGDAPGMNAAIRGVVRA--ALTEGLEVMGIHDGYLGLYEDRMVQLD---RYSVSDMINRGGTFLGSAR-- 73
Cdd:PRK06555 2 AVKKVALLTAGGLAPCLSSAVGGLIERytEIAPEVEIIAYRSGYQGLLLGDSIEITpavRANAGLLHRYGGSPIGNSRvk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 74 FPEFRD----------ENVRAVAIENLKKRGIDALVVIGGD---------GSYMGAK--RLTemgfpCIGLPGTIDNDIK 132
Cdd:PRK06555 82 LTNVADcvkrglvkegENPLKVAAERLAADGVDILHTIGGDdtnttaadlAAYLAENgyDLT-----VVGLPKTIDNDVV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 133 GTDYTIGYFTALGTVVEAIDRLRDTSSSHQRISIV-EVMGRYCGDLTLAAAIA-----GGCEF---------------VV 191
Cdd:PRK06555 157 PIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATARAyrewlDRQEYvpgfglsaerwdihaVY 236
|
250
....*....|....*.
gi 489118935 192 VPEVEFsrdDLVAEIK 207
Cdd:PRK06555 237 LPEMAF---DLEAEAE 249
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
3-223 |
8.42e-16 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 78.09 E-value: 8.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 3 KKIGVLTSGGDAPGMNAAIRGVVR--AALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGG-TFLGSARFPEFRD 79
Cdd:PTZ00468 103 RRIGVVLSGGQASGGHNVIAGLMSyiKLCNQSSQLFGFLGGPEGVYSERYRELTEDDINGILNQGGfNIICSGRHKIETE 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 80 ENVRAvAIENLKKRGIDALVVIGGDGSYMGAKRLTEM------GFPCIGLPGTIDNDIKG--TDYTIGYFTALGTVVEAI 151
Cdd:PTZ00468 183 EQMRA-SLEICEKLKLHGLVVIGGDDSNTNAAVLAEYfkrnssSTVVVGCPKTIDGDLKNevIETSFGYDTAVKTYSEQI 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 152 DRLRDT-SSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPE--VEFSR------DDLVAEIKAGIAKGKKHAIVAIT 222
Cdd:PTZ00468 262 GSIMDAiKTEGYGYYFVRLMGRSASHITLECGLQTRANMILIGEeiKEENRslmsivDEIVEMILKRDSLGKKHGIVLLP 341
|
.
gi 489118935 223 E 223
Cdd:PTZ00468 342 E 342
|
|
| Pyrophosphate_PFK |
cd00765 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
4-228 |
1.77e-15 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.
Pssm-ID: 238390 Cd Length: 550 Bit Score: 76.83 E-value: 1.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 4 KIGVLTSGGDAPGMNAAIRGVVRA--ALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGG-TFLGSARfPEFRDE 80
Cdd:cd00765 74 KIGIVLSGGQAPGGHNVISGLFDYlkERAKGSTLYGFKGGPAGILKCDYIELNAEYIQPYRNTGGfDMICSGR-TKIETE 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 81 NVRAVAIENLKKRGIDALVVIGGDGSYMGAKRLTE------MGFPCIGLPGTIDNDIKG--TDYTIGYFTALGTVVEAID 152
Cdd:cd00765 153 DQFKQAEETAKKLDLDALVVIGGDDSNTNAALLAEnfrskgLKTRVIGVPKTIDGDLKNkeIETSFGFDTATKIYSELIG 232
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489118935 153 RL-RDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEvefsrddlvaEIKAgiakgKKHAIVAITEHMCDV 228
Cdd:cd00765 233 NVmRDARSTGKYWHFVKLMGRSASHIALECALKTHPNICIISE----------EVSA-----QKQTLKNITDYMVDV 294
|
|
| PLN02251 |
PLN02251 |
pyrophosphate-dependent phosphofructokinase |
4-235 |
6.10e-11 |
|
pyrophosphate-dependent phosphofructokinase
Pssm-ID: 215140 Cd Length: 568 Bit Score: 63.27 E-value: 6.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 4 KIGVLTSGGDAPGMNAAIRGVVR--AALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGG-TFLGSAR----FPE 76
Cdd:PLN02251 98 KIGVVLSGGQAPGGHNVISGIFDylQEHAKGSVLYGFKGGPAGIMKCKYVELTAEFIYPYRNQGGfDMICSGRdkieTPE 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 77 -FRDenvravAIENLKKRGIDALVVIGGDGSYMGAKRLTE------MGFPCIGLPGTIDNDIKGTDYTI--GYFTALGTV 147
Cdd:PLN02251 178 qFKQ------AEETATKLDLDGLVVIGGDDSNTNACLLAEyfraknLKTRVIGCPKTIDGDLKSKEVPTsfGFDTACKIY 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 148 VEAI-DRLRDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRDDLVAEIKAGIAK--------GKKHAI 218
Cdd:PLN02251 252 SEMIgNVMIDARSTGKYYHFVRLMGRAASHITLECALQTHPNITIIGEEVAAKKLTLKNVTDYIVDvickraelGYNYGV 331
|
250
....*....|....*...
gi 489118935 219 VAITEHMCD-VDELAHYI 235
Cdd:PLN02251 332 ILIPEGLIDfIPEVQHLI 349
|
|
| PLN03028 |
PLN03028 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional |
4-223 |
4.37e-06 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
Pssm-ID: 215543 Cd Length: 610 Bit Score: 48.23 E-value: 4.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 4 KIGVLTSGGDAPGMNAAIRGVVRA--ALTEGLEVMGIHDGYLGLYEDRMVQLDRYSVSDMINRGG-TFLGSARFPEFRDE 80
Cdd:PLN03028 81 RVGVVFCGRQSPGGHNVIWGLHDAlkAHNPNSVLLGFLGGTEGLFAQKTLEITDDVLSTYKNQGGyDLLGRTKDQIRTTE 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 81 NVRAV--AIENLKkrgIDALVVIGGDGSYMGAKRLTE--MGFPC----IGLPGTIDNDIKG--TDYTIGYFTALGTVVEA 150
Cdd:PLN03028 161 QVNAAlaACEALK---LDGLVIIGGVTSNTDAAQLAEtfAEAKCktkvVGVPVTLNGDLKNqfVETNVGFDTICKVNSQL 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489118935 151 IDRL-RDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFVVV-PEVEFSR---DDLVAEI----KAGIAKGKKHAIVAI 221
Cdd:PLN03028 238 ISNVcTDALSAEKYYYFIRLMGRKASHVALECALQSHPNMVILgEEVAASKltlFDITKQIcdavQARAEQDKNHGVILI 317
|
..
gi 489118935 222 TE 223
Cdd:PLN03028 318 PE 319
|
|
| |
