|
Name |
Accession |
Description |
Interval |
E-value |
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
3-424 |
2.72e-179 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 508.07 E-value: 2.72e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 3 KTYHFIGIKGSGMSALALMLHQMGHHVQGSDVEKYYFTQRgLEQAGIKI-LPFDEKNLQ-ADVeVIAGNAFRPDNnIEIA 80
Cdd:COG0773 5 MHIHFIGIGGIGMSGLAEILLALGYKVSGSDLAESPMTER-LEALGIPVfIGHDAENIDdADL-VVVSSAIPRDN-PELV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 81 YADANGITYKRYHEFLGTFMRDFVSMGVAGAHGKTSTTGMLAHVLSNI-TDTSYLIGD-----GTGRGSANAKYFAFEAD 154
Cdd:COG0773 82 AARERGIPVLSRAEMLAELMRGKRSIAVAGTHGKTTTTSMLAHILEEAgLDPTFLIGGilnnfGTNARLGDGDYFVAEAD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 155 EYERHFMPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQVSKG--LFVYGEDKELRRVTANA--PIYYYGFKEGND 230
Cdd:COG0773 162 ESDGSFLHYSPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYglLVLCADDPGLRELLPRCgrPVITYGFSEDAD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 231 FIAHDLLRSTTGSSFKVSFHGEELGEFKIPSFGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFGGVKRRFTEK-MVNGT 309
Cdd:COG0773 242 YRAENIRIDGGGSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKgEVGGV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 310 TIIDDFAHHPTEIIATLDAARQKYPSKEIVAIFQPHTFTRTIALLDEFAEALNQADAVYLAQIYGsAREVDHGDVKVEDL 389
Cdd:COG0773 322 TVIDDYAHHPTEIAATLAAAREKYPDRRLVAVFQPHRYSRTRDFLDEFAEALSLADEVILLDIYA-AREKPIPGVSSEDL 400
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 489120111 390 AEKIIKK-AEIITVDNVSPLLE------HPNAVYVFMGAGDI 424
Cdd:COG0773 401 AEAIRKRgKDVVYVPDLDELVEalaeiaRPGDVVLTMGAGDI 442
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
4-424 |
1.05e-134 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 394.75 E-value: 1.05e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 4 TYHFIGIKGSGMSALALMLHQMGHHVQGSDVEKYyFTQRGLEQAGIKIL-PFDEKNLqADVEVIAGNAFRPDNNIEIAYA 82
Cdd:TIGR01082 1 KIHFVGIGGIGMSGIAEILLNRGYQVSGSDIAEN-ATTKRLEALGIPIYiGHSAENL-DDADVVVVSAAIKDDNPEIVEA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 83 DANGITYKRYHEFLGTFMRDFVSMGVAGAHGKTSTTGMLAHVLSNI-TDTSYLIGDGTGRGSANAK-----YFAFEADEY 156
Cdd:TIGR01082 79 KERGIPVIRRAEMLAELMRFRHSIAVAGTHGKTTTTAMIAVILKEAgLDPTVVVGGLVKEAGTNARlgsgeYLVAEADES 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 157 ERHFMPYHPEYSIITNIDFDHPD-YFTSLEDVFNAFNDYAKQVSKG--LFVYGEDKELRRVTANA---PIYYYGFKEGND 230
Cdd:TIGR01082 159 DASFLHLQPNVAIVTNIEPDHLDtYGSSFERLKAAFEKFIHNLPFYglAVICADDPVLRELVPKAteqVITYGGSGEDAD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 231 FIAHDLLRSTTGSSFKVSFHGEELGEFKIPSFGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFGGVKRRFTEKM-VNGT 309
Cdd:TIGR01082 239 YRAENIQQSGAEGKFSVRGKGKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEILGeFGGV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 310 TIIDDFAHHPTEIIATLDAARQKYPSKEIVAIFQPHTFTRTIALLDEFAEALNQADAVYLAQIYGSAREVDHGDVkVEDL 389
Cdd:TIGR01082 319 LLIDDYAHHPTEIKATLKAARQGYPDKRIVVVFQPHRYSRTRDLFDDFAKVLSDADELILLDIYAAGEEPINGID-GKSL 397
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 489120111 390 AEKII--KKAEIITVDNVS------PLLEHPNAVYVFMGAGDI 424
Cdd:TIGR01082 398 ARKITqlGKIEPYFVPDLAelveflAAVLQSGDLILTMGAGDI 440
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
5-426 |
1.99e-65 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 224.31 E-value: 1.99e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 5 YHFIGIKGSGMSALALMLHQMGHHVQGSDVEKYYFTQRgLEQAGIKILP-FDEKNLQADVEVIAGNAFRPDNnIEIAYAD 83
Cdd:PRK14573 7 YHFIGIGGIGMSALAHILLDRGYSVSGSDLSEGKTVEK-LKAKGARFFLgHQEEHVPEDAVVVYSSSISKDN-VEYLSAK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 84 ANGITYKRYHEFLGTFMRDFVSMGVAGAHGKTSTTGMLAHVLSNI-TDTSYLIG----DGTGRGSANAKYFAFEADEYER 158
Cdd:PRK14573 85 SRGNRLVHRAELLAELMQEQISILVSGSHGKTTVSSLITAIFQEAkKDPSYAIGglnqEGLNGYSGSSEYFVAEADESDG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 159 HFMPYHPEYSIITNIDFDHPDYFT-SLEDVFNAFNDYAKQVS--KGLFVYGEDKELR-RVTANApiyyYGFKEGNDFiaH 234
Cdd:PRK14573 165 SLKHYTPEFSVITNIDNEHLSNFEgDRELLLASIQDFARKVQqiNKCFYNGDCPRLKgCLQGHS----YGFSSSCDL--H 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 235 DLLRSTTG--SSFKVSFHGEELGEFKIPSFGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFGGVKRRFTEKMVNGTTI- 311
Cdd:PRK14573 239 ILSYYQEGwrSYFSAKFLGVVYQDIELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRLERKNSSETFLf 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 312 IDDFAHHPTEIIATLDAARQKYPSKEIVAIFQPHTFTRTIALLDEFAEALNQADAVYLAQIYgSAREVDHGDVKVEDLAE 391
Cdd:PRK14573 319 LEDYAHHPSEISCTLRAVRDAVGLRRIIAICQPHRFSRLRECLDSFPSAFQDADEVILTDVY-SAGEEPEDSISYQKLAE 397
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 489120111 392 KIIKKAEI----ITVDNVSPLLEHPNAVY---VFMGAGDIQT 426
Cdd:PRK14573 398 AISQSSIVkctyVPFHEIQRYLEQSIRVHdvcVSLGAGNIYT 439
|
|
| mpl |
TIGR01081 |
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase; Alternate name: ... |
6-399 |
2.46e-57 |
|
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase; Alternate name: murein tripeptide ligase [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 130153 [Multi-domain] Cd Length: 448 Bit Score: 195.44 E-value: 2.46e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 6 HFIGIKGSGMSALALMLHQMGHHVQGSDVEKYYFTQRGLEQAGIKILP-FDEKNLQ--ADVeVIAGNAFRPDNNIeIAYA 82
Cdd:TIGR01081 3 HILGICGTFMGGLAMIAKQLGHEVTGSDANVYPPMSTQLEAQGIEIIEgFDAAQLEpkPDL-VVIGNAMKRGNPC-VEAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 83 DANGITYKRYHEFLGTF-MRDFVSMGVAGAHGKTSTTGMLAHVLS-NITDTSYLIGDGTGRGSANAK-----YFAFEADE 155
Cdd:TIGR01081 81 LNLNLPYTSGPQWLHDFvLHDRWVLAVAGTHGKTTTASMLAWVLEqCGLKPGFLIGGVPGNFGVSARlgespFFVIEADE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 156 YE-------RHFMPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQV-SKGLFVY-GEDKELRRVTAN---APIYYY 223
Cdd:TIGR01081 161 YDtaffdkrSKFVHYRPRTLVLNNLEFDHADIFDDLKAIQRQFHHLVRTVpGEGLILCpGRDQSLKDTLAKgcwSEQEFF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 224 GfkEGNDFIAHDLlrSTTGSSFKVSFHGEELGEFKIPSFGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFGGVKRRFTE 303
Cdd:TIGR01081 241 G--EQGEWQAEKI--TADGSHFDVLLDGEKVGEVKWSLVGRHNMHNALMAIAAARHVGVAIEDACEALGSFVNAKRRLEL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 304 K-MVNGTTIIDDFAHHPTEIIATLDAARQKYPSKEIVAIFQPHTFTRTIALL-DEFAEALNQADAVYLAQiygsareVDH 381
Cdd:TIGR01081 317 KgEANGITVYDDFAHHPTAIEATLQGLRQKVGGARILAVLEPRSNTMKLGVHkDDLAPSLGRADQVFLYQ-------PGQ 389
|
410
....*....|....*...
gi 489120111 382 GDVKVEDLAEKIIKKAEI 399
Cdd:TIGR01081 390 IPWDVAEVAAQCVQPANV 407
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
108-277 |
6.83e-25 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 101.23 E-value: 6.83e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 108 VAGAHGKTSTTGMLAHVLSNITDTSYLIGDGTGRGSAN------------------AKYFAFEADEyerHFMPYH----- 164
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTYIGKSGNTtnnaiglpltlaemveagAEYAVLEVSS---HGLGEGrlsgl 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 165 --PEYSIITNIDFDHPDYFTSLEDVFNAFND-YAKQVSKGLFVYGED----KELRRVTANAP--IYYYGFKEGNDFIAHD 235
Cdd:pfam08245 78 lkPDIAVFTNISPDHLDFHGTMENYAKAKAElFEGLPEDGIAVINADdpygAFLIAKLKKAGvrVITYGIEGEADLRAAN 157
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 489120111 236 LLRSTTGSSFKVSFHGEELGEFKIPSFGRHNIMNATAVIGLL 277
Cdd:pfam08245 158 IELSSDGTSFDLFTVPGGELEIEIPLLGRHNVYNALAAIAAA 199
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
107-342 |
4.18e-23 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 101.31 E-value: 4.18e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 107 GVAGAHGKTSTTGMLAHVLSNITDTSYLIGD-GTGRGS------------------------ANAKYFAFEAD----EYE 157
Cdd:COG0769 84 GVTGTNGKTTTTYLLAQILRALGKKTGLIGTvGNGIGGelipsslttpealdlqrllaemvdAGVTHVVMEVSshalDQG 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 158 R----HFmpyhpEYSIITNIDFDHPDYFTSLEDVFNA----FNDYAKqvSKGLFVYGEDKELRRVTANAP--IYYYGFKE 227
Cdd:COG0769 164 RvdgvRF-----DVAVFTNLTRDHLDYHGTMEAYFAAkarlFDQLGP--GGAAVINADDPYGRRLAAAAParVITYGLKA 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 228 GNDFIAHDLLRSTTGSSFKVSFHGEElGEFKIPSFGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFGGVKRRFtEKMVN 307
Cdd:COG0769 237 DADLRATDIELSADGTRFTLVTPGGE-VEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRM-ERVDG 314
|
250 260 270
....*....|....*....|....*....|....*..
gi 489120111 308 GT--TIIDDFAHHPTEIIATLDAARQkYPSKEIVAIF 342
Cdd:COG0769 315 GQgpTVIVDYAHTPDALENVLEALRP-HTKGRLIVVF 350
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
4-103 |
2.19e-21 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 87.67 E-value: 2.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 4 TYHFIGIKGSGMSALALMLHQMGHHVQGSDVEKYyftqrgLEQAGIKILPFDEknlqadveviAGNAFRPDnNIEIAYAD 83
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIES------LIALGAAAVVGHD----------AANNISPD-NPELEAAK 63
|
90 100
....*....|....*....|
gi 489120111 84 ANGITYKRYHEFLGTFMRDF 103
Cdd:pfam01225 64 VPGIPVIDRREALAELAAAF 83
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
107-328 |
7.12e-20 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 91.17 E-value: 7.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 107 GVAGAHGKTSTTGMLAHVLSNITDTSYLIGDGTG---------RGSANAKYFAFEADEYERHFMPY-----HPEYSIITN 172
Cdd:TIGR01143 78 GITGSSGKTTTKEMLAAILSHKYKVFATPGNFNNeiglpltllRAPGDHDYAVLEMGASHPGEIAYlaeiaKPDIAVITN 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 173 IDFDHPDYFTSLEDVFNAFND-YAKQVSKGLFVYGED----KELRRVTANAPIYYYGFkEGNDFIAHDLLRSTTGS-SFK 246
Cdd:TIGR01143 158 IGPAHLEGFGSLEGIAEAKGEiLQGLKENGIAVINADdpafADLAKRLPNRNILSFGF-EGGDFVAKDISYSALGStSFT 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 247 VSFHGEELgEFKIPSFGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFGGVKRRFTEKMVNGTTIIDD-FAHHPTEIIAT 325
Cdd:TIGR01143 237 LVAPGGEF-EVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVQTKNGLTLIDDtYNANPDSMRAA 315
|
...
gi 489120111 326 LDA 328
Cdd:TIGR01143 316 LDA 318
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
107-314 |
1.08e-19 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 90.93 E-value: 1.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 107 GVAGAHGKTSTTGMLAHVLSnitdtsyligdGTGRGSANAKYF---------AFEADEYER---------HF--MPY--- 163
Cdd:COG0770 104 AITGSNGKTTTKEMLAAVLS-----------TKGKVLATPGNFnneigvpltLLRLPEDHEfavlemgmnHPgeIAYlar 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 164 --HPEYSIITNIDFDHPDYFTSLEDVFNA----FNDYAKqvsKGLFVY-GEDKELRRVT--ANAPIYYYGFKEGNDFIAH 234
Cdd:COG0770 173 iaRPDIAVITNIGPAHLEGFGSLEGIARAkgeiFEGLPP---GGVAVLnADDPLLAALAerAKARVLTFGLSEDADVRAE 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 235 DLLRSTTGSSFKVSFHGEELgEFKIPSFGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFGGVKRRFT-EKMVNGTTIID 313
Cdd:COG0770 250 DIELDEDGTRFTLHTPGGEL-EVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEvIEGAGGVTLID 328
|
.
gi 489120111 314 D 314
Cdd:COG0770 329 D 329
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
7-394 |
2.41e-16 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 80.85 E-value: 2.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 7 FIGIKGSGMSALALmLHQMGHHVQGSDV------EKYYFTQRGLEQAGIKILPFDEKNLQADVeVIAGNAFRPDNNIEIA 80
Cdd:TIGR01087 4 ILGLGKTGRAVARF-LHKKGAEVTVTDLkpneelEPSMGQLRLNEGSVLHTGLHLEDLNNADL-VVKSPGIPPDHPLVQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 81 YADANGITYKRYHEFLGTFMRDFVsmGVAGAHGKTSTTGMLAHVLSNITDTSYLIGD-GT----GRGSANAKYFAFEADE 155
Cdd:TIGR01087 82 AAKRGIPVVGDIELFLRLVPLPVV--AITGTNGKTTTTSLLYHLLKAAGLKAFLGGNiGTpaleVLDQEGAELYVLELSS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 156 YERHFMPYH-PEYSIITNIDFDHPDYFTSLEDVFNA-FNDYAKQVSKGLFVYG-EDKELRRVTANAPIYYYGFKEGNDFi 232
Cdd:TIGR01087 160 FQLETTESLrPEIALILNISEDHLDWHGSFEDYVAAkLKIFARQTEGDVAVLNaDDPRFARLAQKSKAQVIWFSVEKDA- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 233 AHDLLRSTTGSSFKVSFHgeelgEFKIPsfGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFGGVKRRFTE-KMVNGTTI 311
Cdd:TIGR01087 239 ERGLCIRDGGLYLKPNDL-----EGSLL--GLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYvGQKNGVHF 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 312 IDDFAhhPTEIIATLDAARQKYpsKEIVAI---------FQPhtftrtialldeFAEALNQADAVYLAqiYGSAREvdhg 382
Cdd:TIGR01087 312 YNDSK--ATNVHATLAALSAFD--NPVILIvggddkgadFSP------------LAPAAAGKVKAVLA--IGEDAA---- 369
|
410
....*....|..
gi 489120111 383 dvKVEDLAEKII 394
Cdd:TIGR01087 370 --KIAPLLKEAG 379
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
107-342 |
5.30e-13 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 70.55 E-value: 5.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 107 GVAGAHGKTSTTGMLAHVLSNITDTSYLIG------DGTGRGSAN-------------------AKYFAFEA-----DEY 156
Cdd:PRK00139 99 GVTGTNGKTTTAYLLAQILRLLGEKTALIGtlgngiGGELIPSGLttpdaldlqrllaelvdagVTYAAMEVsshalDQG 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 157 eR----HFmpyhpEYSIITNIDFDHPDYFTSLEDVFNA-----FNDYAKQVskglfVYGEDKELRRVTANAPIYYYGFKE 227
Cdd:PRK00139 179 -RvdglKF-----DVAVFTNLSRDHLDYHGTMEDYLAAkarlfSELGLAAV-----INADDEVGRRLLALPDAYAVSMAG 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 228 GnDFIAHDLLRSTTGSSFKVSfhgeelGEFKIPSFGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFGGVKRRF-TEKMV 306
Cdd:PRK00139 248 A-DLRATDVEYTDSGQTFTLV------TEVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMeRVDAG 320
|
250 260 270
....*....|....*....|....*....|....*.
gi 489120111 307 NGTTIIDDFAHHPTEIIATLDAARQkYPSKEIVAIF 342
Cdd:PRK00139 321 QGPLVIVDYAHTPDALEKVLEALRP-HAKGRLICVF 355
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
169-330 |
2.24e-12 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 69.35 E-value: 2.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 169 IITNIDFDHPDYFTSLEDVFNA----FNDYakqvsKGL---FVYGEDKELRRVTANAP----IYYYGFKEGNDFIAHDLL 237
Cdd:PRK11929 206 GFTNLTRDHLDYHGTMQDYEEAkaalFSKL-----PGLgaaVINADDPAAARLLAALPrglkVGYSPQNAGADVQARDLR 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 238 RSTTGSSFKVSFHGEELgEFKIPSFGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFGGVKRRFteKMV------NGTTI 311
Cdd:PRK11929 281 ATAHGQVFTLATPDGSY-QLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRM--ERVgptagaQGPLV 357
|
170
....*....|....*....
gi 489120111 312 IDDFAHHPTEIIATLDAAR 330
Cdd:PRK11929 358 VVDYAHTPDALAKALTALR 376
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
297-378 |
3.83e-11 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 58.89 E-value: 3.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 297 VKRRFtEKM--VNGTTIIDDFAHHPTEIIATLDAARQKYPSKeIVAIFQPHTfTRTIALLDEFAEALNQ-ADAVYLAQIY 373
Cdd:pfam02875 1 VPGRL-EVVgeNNGVLVIDDYAHNPDAMEAALRALRNLFPGR-LILVFGGMG-DRDAEFHALLGRLAAAlADVVILTGDY 77
|
....*
gi 489120111 374 GSARE 378
Cdd:pfam02875 78 PRAED 82
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
107-319 |
7.41e-10 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 60.79 E-value: 7.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 107 GVAGAHGKTSTTGMLAHVLSN-------ITDTSYLIGDGTGRGS---------------------ANAKYFAFEADEY-- 156
Cdd:TIGR01085 89 GVTGTNGKTTTTSLIAQLLRLlgkktglIGTIGYRLGGNDLIKNpaalttpealtlqstlaemveAGAQYAVMEVSSHal 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 157 -ERHFMPYHPEYSIITNIDFDHPDYFTSLEDVFNA----FNDYAKQVSKGLFV---YGED--KELRRVTANAPIYYYGFK 226
Cdd:TIGR01085 169 aQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAkaslFTELGLKRFAVINLddeYGAQfvKRLPKDITVSAITQPADG 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 227 EGNDFIAHDLLRSTTGSSFKVSFHGEElGEFKIPSFGRHNIMN-ATAVIGLLYTAGFDLNLVREHLVTFGGVKRRFteKM 305
Cdd:TIGR01085 249 RAQDIKITDSGYSFEGQQFTFETPAGE-GHLHTPLIGRFNVYNlLAALATLLHLGGIDLEDIVAALEKFRGVPGRM--EL 325
|
250
....*....|....*..
gi 489120111 306 VNGT---TIIDDFAHHP 319
Cdd:TIGR01085 326 VDGGqkfLVIVDYAHTP 342
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
107-314 |
2.93e-07 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 52.78 E-value: 2.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 107 GVAGAHGKTSTTGMLAHVLS------NITDTSYLIGDGTG--------RGSANAKYFAFEAD---EYERHFMPYHPEYSI 169
Cdd:PRK11929 607 AITGSNGKTTTKEMIAAILAawqgedRVLATEGNFNNEIGvpltllrlRAQHRAAVFELGMNhpgEIAYLAAIAAPTVAL 686
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 170 ITNIDFDHPDYFTSLEDVFNAFND-YAKQVSKGLFVYGED----KELRRVTANAPIYYYGFKEG-----NDFIAHDLLRS 239
Cdd:PRK11929 687 VTNAQREHQEFMHSVEAVARAKGEiIAALPEDGVAVVNGDdpytAIWAKLAGARRVLRFGLQPGadvyaEKIAKDISVGE 766
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489120111 240 TTGSSFKVSFhGEELGEFKIPSFGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFGGVK-RRFTEKMVNGTTIIDD 314
Cdd:PRK11929 767 AGGTRCQVVT-PAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAgRMQRRRLSCGTRIIDD 841
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
106-327 |
3.39e-05 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 45.92 E-value: 3.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 106 MGVAGAHGKTSTTGMLAHVLSNITDT-----SYLIGDGT----GRGSANAKYFAFE-----ADEYERHFMPYHPEYSIIT 171
Cdd:PRK14093 111 IAVTGSVGKTSTKEALRGVLGAQGEThasvaSFNNHWGVplslARCPADARFAVFEigmnhAGEIEPLVKMVRPHVAIIT 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 172 NIDFDHPDYFTSLEDVFNAFND-YAKQVSKGLFVYGEDKEL-RRVTANAP------IYYYGFKEGNDFIAHDLLRSTTGS 243
Cdd:PRK14093 191 TVEPVHLEFFSGIEAIADAKAEiFTGLEPGGAAVLNRDNPQfDRLAASARaagiarIVSFGADEKADARLLDVALHADCS 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 244 SFKVSFHGEELgEFKIPSFGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFG-----GVKRRFTEKMVNGTTIIDDFAHH 318
Cdd:PRK14093 271 AVHADILGHDV-TYKLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQpaagrGVRHTLEVGGGEATLIDESYNAN 349
|
....*....
gi 489120111 319 PTEIIATLD 327
Cdd:PRK14093 350 PASMAAALG 358
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
107-399 |
4.56e-05 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 45.73 E-value: 4.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 107 GVAGAHGKTSTTGMLAHVLSNITDTSYLIGD----------GTGRG---SANAKYFAFEADEYerhfmpYHPEYSIITNI 173
Cdd:PRK14106 112 AITGTNGKTTTTTLLGEIFKNAGRKTLVAGNigyplidaveEYGEDdiiVAEVSSFQLETIKE------FKPKVGCILNI 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 174 DFDHPDYFTSLEDVFNA-FNDYAKQVSKGLFVYGEDKELRR---VTANAPIYYYG----FKEG----NDFIahdlLRSTT 241
Cdd:PRK14106 186 TPDHLDRHKTMENYIKAkARIFENQRPSDYTVLNYDDPRTRslaKKAKARVIFFSrkslLEEGvfvkNGKI----VISLG 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 242 GSSFKVSfhgeELGEFKIPsfGRHNIMNATAVIGLLYTAGFDLNLVREHLVTFGGVKRRfTEKM--VNGTTIIDDF-AHH 318
Cdd:PRK14106 262 GKEEEVI----DIDEIFIP--GEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHR-IEFVaeINGVKFINDSkGTN 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120111 319 PteiiatlDAArqkypSKEIVAIFQPhtftrtIALL----------DEFAEALN-QADAVYL-----AQIYGSAREVDHG 382
Cdd:PRK14106 335 P-------DAA-----IKALEAYETP------IVLIaggydkgsdfDEFAKAFKeKVKKLILlgetaQEIAEAARKYGFD 396
|
330
....*....|....*...
gi 489120111 383 DV-KVEDLAEKIIKKAEI 399
Cdd:PRK14106 397 NIlFAETLEEAVKKAYEI 414
|
|
| |
