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Conserved domains on  [gi|489120849|ref|WP_003030682|]
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MULTISPECIES: ketose-bisphosphate aldolase [Citrobacter]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 1-277 1.59e-131

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member TIGR00167:

Pssm-ID: 473867  Cd Length: 288  Bit Score: 373.96  E-value: 1.59e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849    1 MLADIKYWENDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTS-FEDFSHMMVSMAKKAS--VPVI 77
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAgLGAISAMVKAMSEAYPygVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   78 THWDHGRSMEIIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNETVY-EEALAGYHYTDPS 156
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGvSVADESALYTDPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  157 QAAEFVERTGCDSLAVAIGNQHGVYTSEPK-LNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQ 235
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYKGEPKgLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQI 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 489120849  236 AAMVAV----QENQDQ--PFLHVeREVRKAVKARALEKIKLFGSDGKA 277
Cdd:TIGR00167 242 AFAAAVrnyyAENKDYydPRVWL-RPGEKAMKEVVLEKIKLFGSANKA 288
 
Name Accession Description Interval E-value
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-277 1.59e-131

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 373.96  E-value: 1.59e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849    1 MLADIKYWENDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTS-FEDFSHMMVSMAKKAS--VPVI 77
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAgLGAISAMVKAMSEAYPygVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   78 THWDHGRSMEIIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNETVY-EEALAGYHYTDPS 156
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGvSVADESALYTDPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  157 QAAEFVERTGCDSLAVAIGNQHGVYTSEPK-LNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQ 235
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYKGEPKgLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQI 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 489120849  236 AAMVAV----QENQDQ--PFLHVeREVRKAVKARALEKIKLFGSDGKA 277
Cdd:TIGR00167 242 AFAAAVrnyyAENKDYydPRVWL-RPGEKAMKEVVLEKIKLFGSANKA 288
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-277 1.02e-122

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 351.31  E-value: 1.02e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   1 MLADIKYWENDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKKASVPVITHW 80
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  81 DHGRSMEIIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHV-GNETVYEEALAGYHYTDPSQAA 159
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVgGEEDGVDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 160 EFVERTGCDSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMV 239
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 489120849 240 AVQEN-QDQP----FLHVEREVRKAVKARALEKIKLFGSDGKA 277
Cdd:COG0191  241 AVREYlAENPdkydPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
10-276 5.34e-113

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 326.68  E-value: 5.34e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   10 NDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTS--FEDFSHMMVSMAKKASVPVITHWDHGRSME 87
Cdd:pfam01116   8 KKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYAggAEALAALVRAAAEAAGVPVALHLDHGASFE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   88 IIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNE---TVYEEALagyhYTDPSQAAEFVER 164
Cdd:pfam01116  88 LIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEedgVVVDEKL----YTDPEEAAEFVEA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  165 TGCDSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAVQEN 244
Cdd:pfam01116 164 TGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTAAVREY 243

                         250       260       270
                  ....*....|....*....|....*....|...
gi 489120849  245 QDQPFLHVE-REVRKAVKARALEKIKLFGSDGK 276
Cdd:pfam01116 244 PPNKDPRKYlRPAEEAMKEVVKEKIRLFGSAGK 276
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 10-275 1.15e-100

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 295.20  E-value: 1.15e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  10 NDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKKASVPVITHWDHGRSMEII 89
Cdd:cd00947    6 KKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGSSFELI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  90 HNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNEtvyEEALAGYH--YTDPSQAAEFVERTGC 167
Cdd:cd00947   86 KRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGE---EDGVVGDEglLTDPEEAEEFVEETGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 168 DSLAVAIGNQHGVYTS-EPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAVQEN-- 244
Cdd:cd00947  163 DALAVAIGTSHGAYKGgEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALREYla 242

                        250       260       270
                 ....*....|....*....|....*....|....
gi 489120849 245 ---QDQPFLHVEREVRKAVKARALEKIKLFGSDG 275
Cdd:cd00947  243 enpKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 10-277 1.17e-85

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 257.36  E-value: 1.17e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  10 NDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKKASVPVITHWDHGRSMEII 89
Cdd:PRK09195  11 NNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQYHHPLALHLDHHEKFDDI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  90 HNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNEtvyEEAL----AGYHYTDPSQAAEFVERT 165
Cdd:PRK09195  91 AQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQ---EDDLqvdeADALYTDPAQAREFVEAT 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 166 GCDSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAVQEnq 245
Cdd:PRK09195 168 GIDSLAVAIGTAHGMYKGEPKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELKIAFSQALKN-- 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 489120849 246 dqpFLHVEREV---RK-------AVKARALEKIKLFGSDGKA 277
Cdd:PRK09195 246 ---YLTEHPEAndpRHylqpaksAMKDVVSKVIADCGCEGKA 284
Fbpase2_Halo NF041368
class II fructose-bisphosphate aldolase;
19-231 2.93e-41

class II fructose-bisphosphate aldolase;


Pssm-ID: 469259  Cd Length: 333  Bit Score: 144.79  E-value: 2.93e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  19 IAHFNVwnaemLMGVIDAAEESKSPVIISFGTG---FVGN----TSFEDFSHMMVSMAKKASVPVITHWDH---GRSMEI 88
Cdd:NF041368  28 VTEPDI-----LVGLLRGAERADSDLVLQVSRGaaaFAGNgdpaAGLRAFGAYLEALAERYDVGVFLNVDHvtlPDDEDF 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  89 IHNAWAHGM-NSLMRDASAFDFEENIRLTKEAVDFFHPLG--IPIEAELGHVG---NETVYEEALagyhYTDPSQAAEFV 162
Cdd:NF041368 103 LDAAVESGIpSSVMVDASAEPFEENVERTREVVEMVDAADedVLVEAELGRIAgveDGIETDEAF----YTDPEQAVEFV 178

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489120849 163 ERTGCDSLAVAIGNQHGVYTS-EPKLNFDVVKRVRQAVS-----VPLVLHGASGISDADIKKAISLGISKINIHT 231
Cdd:NF041368 179 DRTGCDLLAVSVGTQHGVAKGrDLDLRPDLAREIRDALRdhgldTPLVVHGSSGLSPEQVRELLDAGVCKVNKNT 253
 
Name Accession Description Interval E-value
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-277 1.59e-131

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 373.96  E-value: 1.59e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849    1 MLADIKYWENDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTS-FEDFSHMMVSMAKKAS--VPVI 77
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAgLGAISAMVKAMSEAYPygVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   78 THWDHGRSMEIIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNETVY-EEALAGYHYTDPS 156
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGvSVADESALYTDPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  157 QAAEFVERTGCDSLAVAIGNQHGVYTSEPK-LNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQ 235
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYKGEPKgLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQI 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 489120849  236 AAMVAV----QENQDQ--PFLHVeREVRKAVKARALEKIKLFGSDGKA 277
Cdd:TIGR00167 242 AFAAAVrnyyAENKDYydPRVWL-RPGEKAMKEVVLEKIKLFGSANKA 288
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-277 1.02e-122

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 351.31  E-value: 1.02e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   1 MLADIKYWENDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKKASVPVITHW 80
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  81 DHGRSMEIIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHV-GNETVYEEALAGYHYTDPSQAA 159
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVgGEEDGVDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 160 EFVERTGCDSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMV 239
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 489120849 240 AVQEN-QDQP----FLHVEREVRKAVKARALEKIKLFGSDGKA 277
Cdd:COG0191  241 AVREYlAENPdkydPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
10-276 5.34e-113

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 326.68  E-value: 5.34e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   10 NDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTS--FEDFSHMMVSMAKKASVPVITHWDHGRSME 87
Cdd:pfam01116   8 KKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYAggAEALAALVRAAAEAAGVPVALHLDHGASFE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   88 IIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNE---TVYEEALagyhYTDPSQAAEFVER 164
Cdd:pfam01116  88 LIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEedgVVVDEKL----YTDPEEAAEFVEA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  165 TGCDSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAVQEN 244
Cdd:pfam01116 164 TGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTAAVREY 243

                         250       260       270
                  ....*....|....*....|....*....|...
gi 489120849  245 QDQPFLHVE-REVRKAVKARALEKIKLFGSDGK 276
Cdd:pfam01116 244 PPNKDPRKYlRPAEEAMKEVVKEKIRLFGSAGK 276
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 10-275 1.15e-100

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 295.20  E-value: 1.15e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  10 NDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKKASVPVITHWDHGRSMEII 89
Cdd:cd00947    6 KKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGSSFELI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  90 HNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNEtvyEEALAGYH--YTDPSQAAEFVERTGC 167
Cdd:cd00947   86 KRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGE---EDGVVGDEglLTDPEEAEEFVEETGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 168 DSLAVAIGNQHGVYTS-EPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAVQEN-- 244
Cdd:cd00947  163 DALAVAIGTSHGAYKGgEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALREYla 242

                        250       260       270
                 ....*....|....*....|....*....|....
gi 489120849 245 ---QDQPFLHVEREVRKAVKARALEKIKLFGSDG 275
Cdd:cd00947  243 enpKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 10-277 1.17e-85

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 257.36  E-value: 1.17e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  10 NDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKKASVPVITHWDHGRSMEII 89
Cdd:PRK09195  11 NNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQYHHPLALHLDHHEKFDDI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  90 HNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNEtvyEEAL----AGYHYTDPSQAAEFVERT 165
Cdd:PRK09195  91 AQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQ---EDDLqvdeADALYTDPAQAREFVEAT 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 166 GCDSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAVQEnq 245
Cdd:PRK09195 168 GIDSLAVAIGTAHGMYKGEPKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELKIAFSQALKN-- 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 489120849 246 dqpFLHVEREV---RK-------AVKARALEKIKLFGSDGKA 277
Cdd:PRK09195 246 ---YLTEHPEAndpRHylqpaksAMKDVVSKVIADCGCEGKA 284
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
11-277 6.00e-80

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 243.06  E-value: 6.00e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  11 DAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKKASVPVITHWDHGRSMEIIH 90
Cdd:PRK12737  12 KAQAEGYAVPAFNIHNLETLQVVVETAAELRSPVILAGTPGTFSYAGTDYIVAIAEVAARKYNIPLALHLDHHEDLDDIK 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  91 NAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVG---NETVYEEALAgyHYTDPSQAAEFVERTGC 167
Cdd:PRK12737  92 KKVRAGIRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRLGgqeDDLVVDEKDA--MYTNPDAAAEFVERTGI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 168 DSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAVQ----E 243
Cdd:PRK12737 170 DSLAVAIGTAHGLYKGEPKLDFERLAEIREKVSIPLVLHGASGVPDEDVKKAISLGICKVNVATELKIAFSDAVKkyfyE 249

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 489120849 244 NQD--QPfLHVEREVRKAVKARALEKIKLFGSDGKA 277
Cdd:PRK12737 250 NPKanDP-RKYMTPGKAAMKEVVREKIKVCGSEGKL 284
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 10-277 7.51e-80

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 242.65  E-value: 7.51e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   10 NDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTS-FEDFSHMMVSMAKKAS-VPVITHWDHGRSME 87
Cdd:TIGR01859   9 QKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGgYKMAVAMVKTLIERMSiVPVALHLDHGSSYE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   88 IIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNEtvyEEALAGY--HYTDPSQAAEFVERT 165
Cdd:TIGR01859  89 SCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGI---EDGVDEKeaELADPDEAEQFVKET 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  166 GCDSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTElCQAAMVA----- 240
Cdd:TIGR01859 166 GVDYLAAAIGTSHGKYKGEPGLDFERLKEIKELTNIPLVLHGASGIPEEQIKKAIKLGIAKINIDTD-CRIAFTAairkv 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 489120849  241 VQENQDQ----PFLhveREVRKAVKARALEKIKLFGSDGKA 277
Cdd:TIGR01859 245 LTEKKDEydprKIL---GPAREAIKETVKEKMRLFGSAGKA 282
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
11-277 8.05e-79

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 240.01  E-value: 8.05e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  11 DAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKKASVPVITHWDHGRSMEIIH 90
Cdd:PRK12857  12 KAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEYISAMVRTAAEKASVPVALHLDHGTDFEQVM 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  91 NAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVG----NETVYE-EALagyhYTDPSQAAEFVERT 165
Cdd:PRK12857  92 KCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGgtedDITVDErEAA----MTDPEEARRFVEET 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 166 GCDSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAVQEN- 244
Cdd:PRK12857 168 GVDALAIAIGTAHGPYKGEPKLDFDRLAKIKELVNIPIVLHGSSGVPDEAIRKAISLGVRKVNIDTNIREAFVARLREVl 247

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 489120849 245 QDQPFLHVEREV----RKAVKARALEKIKLFGSDGKA 277
Cdd:PRK12857 248 EKNPDEIDPRKIlgpaREAAKEVIREKIRLFGSAGKA 284
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
12-277 4.97e-75

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 230.41  E-value: 4.97e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  12 AQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKKASVPVITHWDHGRSMEIIHN 91
Cdd:PRK06801  13 ARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINIAEVHFKYISLESLVEAVKFEAARHDIPVVLNLDHGLHFEAVVR 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  92 AWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNE---TVYEEALAGYhYTDPSQAAEFVERTGCD 168
Cdd:PRK06801  93 ALRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVGGDeggALYGEADSAK-FTDPQLARDFVDRTGID 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 169 SLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAVQ------ 242
Cdd:PRK06801 172 ALAVAIGNAHGKYKGEPKLDFARLAAIHQQTGLPLVLHGGSGISDADFRRAIELGIHKINFYTGMSQAALAAVEqrmthr 251

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 489120849 243 ENQDQPFLHVEREVRKAVKARALEKIKLFGSDGKA 277
Cdd:PRK06801 252 HAIYDEFAELLLGIEEAISDTVAQQMRIFGSAGQA 286
PRK08185 PRK08185
hypothetical protein; Provisional
 12-278 1.70e-74

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 228.84  E-value: 1.70e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  12 AQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTG---FVGNtsfeDFSHMMVSMAKKASVPVITHWDHGRSMEI 88
Cdd:PRK08185   8 AKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIHPNeldFLGD----NFFAYVRERAKRSPVPFVIHLDHGATIED 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  89 IHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVG-NETVYEEALAGYHYTDPSQAAEFVERTGC 167
Cdd:PRK08185  84 VMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGnTGTSIEGGVSEIIYTDPEQAEDFVSRTGV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 168 DSLAVAIGNQHGVYTS--EPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAVQEN- 244
Cdd:PRK08185 164 DTLAVAIGTAHGIYPKdkKPELQMDLLKEINERVDIPLVLHGGSANPDAEIAESVQLGVGKINISSDMKYAFFKKVREIl 243

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 489120849 245 QDQPFLH----VEREVRKAVKARALEKIKLFGSDGKAE 278
Cdd:PRK08185 244 SDNPSLYepnqIYPSAIEAAKEVVRHKMDLFNSTGKAD 281
PRK06806 PRK06806
class II aldolase;
2-277 8.69e-74

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 226.95  E-value: 8.69e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   2 LADIKYWENDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKKASVPVITHWD 81
Cdd:PRK06806   3 LVQMKELLKKANQENYGVGAFSVANMEMVMGAIKAAEELNSPIILQIAEVRLNHSPLHLIGPLMVAAAKQAKVPVAVHFD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  82 HGRSMEIIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVG-NETVYEEAlaGYHYTDPSQAAE 160
Cdd:PRK06806  83 HGMTFEKIKEALEIGFTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVGgSEDGSEDI--EMLLTSTTEAKR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 161 FVERTGCDSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVA 240
Cdd:PRK06806 161 FAEETDVDALAVAIGNAHGMYNGDPNLRFDRLQEINDVVHIPLVLHGGSGISPEDFKKCIQHGIRKINVATATFNSVITA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 489120849 241 VQE----NQDQPFLHVEREVRKAVKARALEKIKLFGSDGKA 277
Cdd:PRK06806 241 VNNlvlnTPYSDYFTYHQDVIKAAYENVKKHMQIFGSENKA 281
gatY PRK07998
class II aldolase;
12-273 2.50e-68

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 213.08  E-value: 2.50e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  12 AQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKKASVPVITHWDHGRSMEIIHN 91
Cdd:PRK07998  13 IQEKHVLAGAFNTTNLETTISILNAIERSGLPNFIQIAPTNAQLSGYDYIYEIVKRHADKMDVPVSLHLDHGKTFEDVKQ 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  92 AWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHV-GNETvyEEALAGYHYTDPSQAAEFVERTGCDSL 170
Cdd:PRK07998  93 AVRAGFTSVMIDGAALPFEENIAFTKEAVDFAKSYGVPVEAELGAIlGKED--DHVSEADCKTEPEKVKDFVERTGCDML 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 171 AVAIGNQHGVYTSePKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAV----QENQD 246
Cdd:PRK07998 171 AVSIGNVHGLEDI-PRIDIPLLKRIAEVSPVPLVIHGGSGIPPEILRSFVNYKVAKVNIASDLRKAFITTVgkayVNNHN 249

                        250       260
                 ....*....|....*....|....*...
gi 489120849 247 QPFL-HVEREVRKAVKARALEKIKLFGS 273
Cdd:PRK07998 250 EANLaRVMAKAKQAVEEDVYSKIKMMNS 277
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 2-277 2.15e-64

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 203.36  E-value: 2.15e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   2 LADIKYWENDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGN-TSFEDFSHMMVSMAKKA--SVPVIT 78
Cdd:PRK07709   3 LVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHmTGFKTVVAMVKALIEEMniTVPVAI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  79 HWDHGRSMEIIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNETvyEEALA-GYHYTDPSQ 157
Cdd:PRK07709  83 HLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQE--DDVIAeGVIYADPAE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 158 AAEFVERTGCDSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAA 237
Cdd:PRK07709 161 CKHLVEATGIDCLAPALGSVHGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIEF 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 489120849 238 MVAVQE--NQDQPFLHVEREV---RKAVKARALEKIKLFGSDGKA 277
Cdd:PRK07709 241 TKAVREvlNKDQEVYDPRKFIgpgRDAIKATVIGKIREFGSNGKA 285
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
6-243 1.70e-63

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 201.03  E-value: 1.70e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   6 KYWENDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKKASVPVITHWDHGRS 85
Cdd:PRK12738   7 KYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHES 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  86 MEIIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVG----NETVYEEALagyHYTDPSQAAEF 161
Cdd:PRK12738  87 LDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGgvedDMSVDAESA---FLTDPQEAKRF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 162 VERTGCDSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAV 241
Cdd:PRK12738 164 VELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAV 243


                 ..
gi 489120849 242 QE 243
Cdd:PRK12738 244 KA 245
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 2-278 2.23e-63

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 200.60  E-value: 2.23e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   2 LADIKYWENDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTG---FVGntSFEDFSHMMVSMA--KKASVPV 76
Cdd:PRK08610   3 LVSMKEMLIDAKENGYAVGQYNLNNLEFTQAILEASQEENAPVILGVSEGaarYMS--GFYTVVKMVEGLMhdLNITIPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  77 ITHWDHGRSMEIIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNETvyEEALA-GYHYTDP 155
Cdd:PRK08610  81 AIHLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQE--DDVVAdGIIYADP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 156 SQAAEFVERTGCDSLAVAIGNQHGVYTSEPKLNFDVVKRVRQAVSVPLVLHGASGISDADIKKAISLGISKINIHTELCQ 235
Cdd:PRK08610 159 KECQELVEKTGIDALAPALGSVHGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQI 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 489120849 236 AAMVAVQENQD-QPFLHVERE----VRKAVKARALEKIKLFGSDGKAE 278
Cdd:PRK08610 239 ASAKAVRDVLNnDKEVYDPRKylgpAREAIKETVKGKIKEFGTSNRAK 286
PLN02858 PLN02858
fructose-bisphosphate aldolase
 11-277 1.33e-53

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 187.37  E-value: 1.33e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   11 DAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFShMMVSMAKKASVPVITHWDHGRSMEIIH 90
Cdd:PLN02858 1108 NAEKGGYAVGAFNVYNLEGIEAVVAAAEAEKSPAILQVHPGALKQGGIPLVS-CCIAAAEQASVPITVHFDHGTSKHELL 1186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   91 NAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHV-GNE---TVYE-EAlagyHYTDPSQAAEFVERT 165
Cdd:PLN02858 1187 EALELGFDSVMVDGSHLSFTENISYTKSISSLAHSKGLMVEAELGRLsGTEdglTVEEyEA----KLTDVDQAKEFIDET 1262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  166 GCDSLAVAIGNQHGVY-TSEPKLNFDVVKRVRQAVS---VPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAV 241
Cdd:PLN02858 1263 GIDALAVCIGNVHGKYpASGPNLRLDLLKELRALSSkkgVLLVLHGASGLPESLIKECIENGVRKFNVNTEVRTAYMEAL 1342

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 489120849  242 QENQDQPFLHVEREVRKAVKARALEKIKLFGSDGKA 277
Cdd:PLN02858 1343 SSPKKTDLIDVMSAAKEAMKAVVAEKLRLFGSAGKA 1378
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
12-276 1.17e-48

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 163.60  E-value: 1.17e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  12 AQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEdfshMMVSMAKKAS-----VPVITHWDHGRSM 86
Cdd:PRK05835  12 AHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGID----MAVGMVKIMCeryphIPVALHLDHGTTF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  87 EIIHNAWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHV----GNETVYEEALAgyhYTDPSQAAEFV 162
Cdd:PRK05835  88 ESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLmgieDNISVDEKDAV---LVNPKEAEQFV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 163 ERTGCDSLAVAIGNQHGV--YTSEPKLNFDVVKRVRQAVSVPLVLHGASGISD----------ADIK-----------KA 219
Cdd:PRK05835 165 KESQVDYLAPAIGTSHGAfkFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDdvrksyldagGDLKgskgvpfeflqES 244

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489120849 220 ISLGISKINIHTELCQAAMVAVQE--NQDQPFLHVER---EVRKAVKARALEKIKLFGSDGK 276
Cdd:PRK05835 245 VKGGINKVNTDTDLRIAFIAEVRKvaNEDKSQFDLRKffsPAQLALKNVVKERMKLLGSANK 306
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
17-277 2.76e-45

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 155.27  E-value: 2.76e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  17 YAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTG---FVGNTSFEDFSHMMVSMAKK--ASVPVITHWDHGRSMEIIHN 91
Cdd:PRK07084  24 YAIPAYNFNNMEQLQAIIQACVETKSPVILQVSKGarkYANATLLRYMAQGAVEYAKElgCPIPIVLHLDHGDSFELCKD 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  92 AWAHGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELG---HVGNETVYEEalagYHYTDPSQAAEFVERTGCD 168
Cdd:PRK07084 104 CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGvlaGVEDEVSAEH----HTYTQPEEVEDFVKKTGVD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 169 SLAVAIGNQHGVYT-----SEPKLNFDVVKRVRQAV-SVPLVLHGAS---------------------GISDADIKKAIS 221
Cdd:PRK07084 180 SLAISIGTSHGAYKfkpgqCPPPLRFDILEEIEKRIpGFPIVLHGSSsvpqeyvktineyggklkdaiGIPEEQLRKAAK 259

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489120849 222 LGISKINIHTELCQAAMVAVQENQDQpflHVER--------EVRKAVKARALEKIK-LFGSDGKA 277
Cdd:PRK07084 260 SAVCKINIDSDGRLAMTAAIRKVFDE---KPEEfdprkylgPARDELKKLYKHKIInVLGSNGKA 321
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 5-241 1.09e-41

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 146.11  E-value: 1.09e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849   5 IKYWENDAQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISF---GTGFV-------------GNTSFEDFSHMMVSM 68
Cdd:cd00453    1 VQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFsngGASFIagkgvksdvpqgaAILGAISGAHHVHQM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  69 AKKASVPVITHWDHGRSMEI------IHNAWAHG-------MNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELG 135
Cdd:cd00453   81 AEHYGVPVILHTDHCAKKLLpwidglLDAGEKHFaatgkplFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 136 HVG-------NETVYEEALagyhYTDPSQAAEFVERTGC----DSLAVAIGNQHGVYT-SEPKLNFDVVKRVRQAVS--- 200
Cdd:cd00453  161 CTGgeedgvdNSHMDASAL----YTQPEDVDYAYTELSKisprFTIAASFGNVHGVYKkGNVVLTPTILRDSQEYVSkkh 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 489120849 201 ------VPLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAV 241
Cdd:cd00453  237 nlphnsLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGV 283
Fbpase2_Halo NF041368
class II fructose-bisphosphate aldolase;
19-231 2.93e-41

class II fructose-bisphosphate aldolase;


Pssm-ID: 469259  Cd Length: 333  Bit Score: 144.79  E-value: 2.93e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  19 IAHFNVwnaemLMGVIDAAEESKSPVIISFGTG---FVGN----TSFEDFSHMMVSMAKKASVPVITHWDH---GRSMEI 88
Cdd:NF041368  28 VTEPDI-----LVGLLRGAERADSDLVLQVSRGaaaFAGNgdpaAGLRAFGAYLEALAERYDVGVFLNVDHvtlPDDEDF 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  89 IHNAWAHGM-NSLMRDASAFDFEENIRLTKEAVDFFHPLG--IPIEAELGHVG---NETVYEEALagyhYTDPSQAAEFV 162
Cdd:NF041368 103 LDAAVESGIpSSVMVDASAEPFEENVERTREVVEMVDAADedVLVEAELGRIAgveDGIETDEAF----YTDPEQAVEFV 178

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489120849 163 ERTGCDSLAVAIGNQHGVYTS-EPKLNFDVVKRVRQAVS-----VPLVLHGASGISDADIKKAISLGISKINIHT 231
Cdd:NF041368 179 DRTGCDLLAVSVGTQHGVAKGrDLDLRPDLAREIRDALRdhgldTPLVVHGSSGLSPEQVRELLDAGVCKVNKNT 253
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 12-277 3.30e-39

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 138.48  E-value: 3.30e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  12 AQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTG---FVGNTSFED--FSHMMVSMAkkASVPVITHWDHGR-- 84
Cdd:PRK07315  13 ARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGaakYMGGYKVCKnlIENLVESMG--ITVPVAIHLDHGHye 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  85 -SMEIIHNawahGMNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGNEtvyEEALAGYHYTDPSQAAEFVE 163
Cdd:PRK07315  91 dALECIEV----GYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGE---EDGIIGKGELAPIEDAKAMV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 164 RTGCDSLAVAIGNQHGVYTSEPK-LNFDVVKRVRQAVS-VPLVLHGASGISDADIKKAISLGISKINIHTElCQAAMVAV 241
Cdd:PRK07315 164 ETGIDFLAAGIGNIHGPYPENWEgLDLDHLEKLTEAVPgFPIVLHGGSGIPDDQIQEAIKLGVAKVNVNTE-CQIAFANA 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489120849 242 QENQDQPFLHVEREVRK---------------AVKARALEKIKLFGSDGKA 277
Cdd:PRK07315 243 TRKFARDYEANEAEYDKkklfdprkflapgvkAIQASVEERIDVFGSANKA 293
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
17-277 4.31e-38

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 137.01  E-value: 4.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  17 YAIAHFNVWNAEMLMGVIDAAEESKSPVII--SFGTGFVGNTSFedFSHMMVSMAKK-ASVPVITHWDHGRSMEIIHNAW 93
Cdd:PRK09196  18 YGVPAFNVNNLEQVQAIMEAADETDSPVILqaSAGARKYAGEPF--LRHLILAAVEEyPHIPVVMHQDHGNSPATCQRAI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  94 AHGMNSLMRDAS-------AFDFEENIRLTKEAVDFFHPLGIPIEAELGHVGN-ETVYEEALAGY----------HYTDP 155
Cdd:PRK09196  96 QLGFTSVMMDGSlkadgktPASYEYNVDVTRKVVEMAHACGVSVEGELGCLGSlETGMGGEEDGHgaegklshdqLLTDP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 156 SQAAEFVERTGCDSLAVAIGNQHGVY--TSEPK---LNFDVVKRVRQAV-SVPLVLHGAS-------------------- 209
Cdd:PRK09196 176 EEAADFVKKTQVDALAIAIGTSHGAYkfTRKPTgdvLAIDRIKEIHARLpNTHLVMHGSSsvpqelldiineyggdmpet 255

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489120849 210 -GISDADIKKAISLGISKINIHTELCQAAMVAV----QENQDQ--P--FLHVEREVRKAV-KARALEkiklFGSDGKA 277
Cdd:PRK09196 256 yGVPVEEIQEGIKHGVRKVNIDTDLRLAMTGAIrrflAENPSEfdPrkYLKPAMEAMKKIcKARYEA----FGTAGQA 329
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
17-277 1.31e-32

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 122.58  E-value: 1.31e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  17 YAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTGFVGNTSFEDFSHMMVSMAKK-ASVPVITHWDHGRSMEIIHNAWAH 95
Cdd:PRK13399  18 YGVPAFNVNNMEQILAIMEAAEATDSPVILQASRGARKYAGDAMLRHMVLAAAEMyPDIPICLHQDHGNSPATCQSAIRS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  96 GMNSLMRDASAF-------DFEENIRLTKEAVDFFHPLGIPIEAELGHVGN-ETVYEEALAGYHY----------TDPSQ 157
Cdd:PRK13399  98 GFTSVMMDGSLLadgktpaSYDYNVDVTRRVTEMAHAVGVSVEGELGCLGSlETGEAGEEDGVGAegklshdqmlTDPDQ 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 158 AAEFVERTGCDSLAVAIGNQHGVY--TSEPK---LNFDVVKRVRQAV-SVPLVLHGAS---------------------G 210
Cdd:PRK13399 178 AVDFVQRTGVDALAIAIGTSHGAYkfTRKPDgdiLAIDRIEEIHARLpNTHLVMHGSSsvpqelqeiinayggkmketyG 257

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489120849 211 ISDADIKKAISLGISKINIHTELCQA---AMVAVQENQDQPFlhverEVRKAVK-----ARAL--EKIKLFGSDGKA 277
Cdd:PRK13399 258 VPVEEIQRGIKHGVRKVNIDTDIRLAmtgAIRKVLAEHPSEF-----DPRKALKpamkaMTALckQRFEAFGTAGQA 329
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 12-231 1.15e-24

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 101.03  E-value: 1.15e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  12 AQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTG---F---------------VGNTSFEDFSHMMvsmAKKAS 73
Cdd:PRK09197  16 AKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIIQFSNGgaaFiagkgvkddgqgaavLGAIAGAKHVHEV---AEHYG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  74 VPVITHWDHGRS---------MEIIHNAWAHGMNSL----MRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVG-- 138
Cdd:PRK09197  93 VPVILHTDHCAKkllpwidglLDAGEKHFAAGGKPLfsshMIDLSEEPLEENIEICSKYLERMAKAGMTLEIELGVTGge 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 139 -----NETVYEEALagyhYTDPSQAAEFVERTGCDS----LAVAIGNQHGVYtsEP---KLNFDVVKRVRQAVS------ 200
Cdd:PRK09197 173 edgvdNSHEDNSKL----YTQPEDVLYAYEALGKISgrftIAASFGNVHGVY--KPgnvKLRPEILKDSQEYVSkkfglp 246

                        250       260       270
                 ....*....|....*....|....*....|....
gi 489120849 201 ---VPLVLHGASGISDADIKKAISLGISKINIHT 231
Cdd:PRK09197 247 akpFDFVFHGGSGSTLEEIREAVSYGVVKMNIDT 280
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 12-243 8.78e-22

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 92.82  E-value: 8.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  12 AQNKHYAIAHFNVWNAEMLMGVIDAAEESKSPVIISFGTG---FVGNTSFED------------FSHMMVSMAKKASVPV 76
Cdd:cd00946   11 AKENGFAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSNGgaaFYAGKGLKNekqkasiagaiaAAHHVRSMAEHYGVPV 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849  77 ITHWDHG--------RSMEIIHNAW--AHG---MNSLMRDASAFDFEENIRLTKEAVDFFHPLGIPIEAELGHVG----- 138
Cdd:cd00946   91 VLHTDHCakkllpwfDGLLEADEEYfkQHGeplFSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEMEIGITGgeedg 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 139 --NETVYEEALagyhYTDPSQAAEFVERTGCDS----LAVAIGNQHGVYTS-----EPKLNFDVVKRVRQAVS------V 201
Cdd:cd00946  171 vdNSGVDNAEL----YTQPEDVWYVYEALSKISpnfsIAAAFGNVHGVYKPgnvklQPEILGEHQDYVREKLGladdkpL 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 489120849 202 PLVLHGASGISDADIKKAISLGISKINIHTELCQAAMVAVQE 243
Cdd:cd00946  247 YFVFHGGSGSTKEEIREAISYGVVKMNIDTDTQWAYWEGVRN 288
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
159-224 2.62e-04

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 42.23  E-value: 2.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489120849 159 AEFVERTGCDSLAvaIGNQHGVYTsePKLNFDVVKRVRQAVSVPLVL--HGASGISDADIKKAISLGI 224
Cdd:PRK14040 161 AKQLEDMGVDSLC--IKDMAGLLK--PYAAYELVSRIKKRVDVPLHLhcHATTGLSTATLLKAIEAGI 224
PRK12331 PRK12331
oxaloacetate decarboxylase subunit alpha;
157-228 4.81e-04

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 183446 [Multi-domain]  Cd Length: 448  Bit Score: 41.23  E-value: 4.81e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489120849 157 QAAEFVERTGCDSlaVAIGNQHGVYTsePKLNFDVVKRVRQAVSVPLVLHG--ASGISDADIKKAISLGISKIN 228
Cdd:PRK12331 158 KLAKEMQEMGADS--ICIKDMAGILT--PYVAYELVKRIKEAVTVPLEVHThaTSGIAEMTYLKAIEAGADIID 227
HisA cd04732
HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase ...
 138-231 6.72e-03

HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-ribosyl)-4-imidazolecarboxamide). In bacteria and archaea, ProFAR isomerase is encoded by the HisA gene.


Pssm-ID: 240083  Cd Length: 234  Bit Score: 37.07  E-value: 6.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120849 138 GNETVYeealagyhYTDPSQAAEFVERTGCDSLAV-----AIGNQhgvytsepKLNFDVVKRVRQAVSVPLVLHGasGI- 211
Cdd:cd04732   22 DKKTVY--------SDDPVEVAKKWEEAGAKWLHVvdldgAKGGE--------PVNLELIEEIVKAVGIPVQVGG--GIr 83

                         90       100
                 ....*....|....*....|
gi 489120849 212 SDADIKKAISLGISKINIHT 231
Cdd:cd04732   84 SLEDIERLLDLGVSRVIIGT 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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