|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11394 |
PRK11394 |
23S rRNA pseudouridine(2457) synthase RluE; |
1-204 |
1.42e-131 |
|
23S rRNA pseudouridine(2457) synthase RluE;
Pssm-ID: 183115 Cd Length: 217 Bit Score: 368.30 E-value: 1.42e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 1 MQKTSFRNHRVERFSSRQVTKQRKENQPKRVVLFNKPYDVLPQFTDEAGRSTLKDFIPLPGIYAAGRLDRDSEGLLVLTN 80
Cdd:PRK11394 11 MQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTN 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 81 DGALQARLTQPGKRTGKIYYVQVEGEPTAEALDALRTGVTLNDGPTLPAGIEVVEEPVWLWPRNPPIRERKNIPTSWLKV 160
Cdd:PRK11394 91 NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKI 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 489120937 161 TLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYTLENLANGEWRE 204
Cdd:PRK11394 171 TLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
|
|
| PseudoU_synth_RluE |
cd02566 |
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins ... |
31-197 |
4.11e-104 |
|
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. Escherichia coli RluE makes psi2457 in 23S RNA. psi2457 is not universally conserved.
Pssm-ID: 211334 [Multi-domain] Cd Length: 168 Bit Score: 296.99 E-value: 4.11e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 31 VVLFNKPYDVLPQFTDEA-GRSTLKDFIPLPGIYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGEPTA 109
Cdd:cd02566 1 LILFNKPYGVLSQFTDESeKHKTLKDYIDDPGVYAAGRLDRDSEGLLLLTDDGRLQHRITDPSFKHPKTYYVQVEGVPTE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 110 EALDALRTGVTLNDGPTLPAGIEVVEEPVWLWPRNPPIRERKNIPTSWLKVTLYEGRNRQVRRMTAHVGFPTLRLIRYAM 189
Cdd:cd02566 81 DALEQLRNGVELGDGLTLPAKVEKVDEPPWLWEREPPIRFRKNIPTSWIEITICEGKNRQVRRMTAAVGFPTLRLIRVSI 160
|
....*...
gi 489120937 190 GDYTLENL 197
Cdd:cd02566 161 GDIGLDNL 168
|
|
| TIGR00093 |
TIGR00093 |
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that ... |
65-205 |
1.26e-61 |
|
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that RNA modifications involved in maturing the protein translation apparatus. Counts per genome vary: two in Staphylococcus aureus, three in Pseudomonas putida, four in E. coli, etc. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 272902 Cd Length: 128 Bit Score: 187.92 E-value: 1.26e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 65 AGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGEPTAEALDALRTGVTLNDGPTLPAGIEVVEEPVWlwprn 144
Cdd:TIGR00093 1 VGRLDRDSEGLLLLTNDGELVHRLTHPGHHHEKEYLVTVEGPVTDEDLEALRKGVQLEDGKTKPAKLKVITEPGF----- 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489120937 145 ppirerkniPTsWLKVTLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYTLENLANGEWREL 205
Cdd:TIGR00093 76 ---------PT-WLRVTLSEGRNRQVRRMFAAVGFPVLRLHRVRIGDVSLNGLPPGEWRPL 126
|
|
| RsuA |
COG1187 |
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ... |
24-205 |
3.95e-61 |
|
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ribosomal structure and biogenesis]; Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 440800 [Multi-domain] Cd Length: 226 Bit Score: 190.24 E-value: 3.95e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 24 KENQPKRVVLFNKPYDVLPQFTDEAGRSTLKDFIP---LPGIYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYY 100
Cdd:COG1187 57 KLPEEPVYLLLNKPAGVVSTTKDPEGRPTVFDLLPearKERLFPVGRLDKDTEGLLLLTNDGELAHRLTHPKYGVEKEYL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 101 VQVEGEPTAEALDALRTGVTLNDGPTLPAGIEVVeepvwlwprnppirerKNIPTSWLKVTLYEGRNRQVRRMTAHVGFP 180
Cdd:COG1187 137 VRVDGPVTEEDLERLREGVELEDGPTKPAKVEIL----------------SGEANTWLRITLTEGRNRQVRRMFEAVGLP 200
|
170 180
....*....|....*....|....*
gi 489120937 181 TLRLIRYAMGDYTLENLANGEWREL 205
Cdd:COG1187 201 VVRLKRVRIGPLTLGDLPPGEWREL 225
|
|
| PseudoU_synth_2 |
pfam00849 |
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA ... |
31-176 |
2.34e-18 |
|
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA.
Pssm-ID: 459961 [Multi-domain] Cd Length: 151 Bit Score: 77.83 E-value: 2.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 31 VVLFNKPYDVLPQFTD-EAGRSTLKDFIPLPG-----IYAAGRLDRDSEGLLVLTNDGALQARLTQ--PGKRTGKIYYVQ 102
Cdd:pfam00849 1 YIVVNKPAGVPVHPTDsLTKLLSLLALLLRRElgvkrLYPVHRLDKNTSGLLLLAKDGEAANKLNKlfPERKIEKEYLAL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489120937 103 VEGEPTAEALDALRTGVTLNDGPTLPAGIEVVEEPVWLWprnPPIRERKNIPTSWLKVTLYEGRNRQVRRMTAH 176
Cdd:pfam00849 81 VDKPEEEEGTIKSPIKKEKNKSPFRKEEELGGKKAVTHL---KVLKSGSKGDYSLLELELVTGRKHQIRAHLAA 151
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11394 |
PRK11394 |
23S rRNA pseudouridine(2457) synthase RluE; |
1-204 |
1.42e-131 |
|
23S rRNA pseudouridine(2457) synthase RluE;
Pssm-ID: 183115 Cd Length: 217 Bit Score: 368.30 E-value: 1.42e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 1 MQKTSFRNHRVERFSSRQVTKQRKENQPKRVVLFNKPYDVLPQFTDEAGRSTLKDFIPLPGIYAAGRLDRDSEGLLVLTN 80
Cdd:PRK11394 11 MQKTSFRNHQVKRFSSQRSTRRKPENQPTRVILFNKPYDVLPQFTDEAGRKTLKEFIPVQGVYAAGRLDRDSEGLLVLTN 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 81 DGALQARLTQPGKRTGKIYYVQVEGEPTAEALDALRTGVTLNDGPTLPAGIEVVEEPVWLWPRNPPIRERKNIPTSWLKV 160
Cdd:PRK11394 91 NGALQARLTQPGKRTGKIYYVQVEGIPTQDALEALRNGVTLNDGPTLPAGAELVDEPAWLWPRNPPIRERKSIPTSWLKI 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 489120937 161 TLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYTLENLANGEWRE 204
Cdd:PRK11394 171 TLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYSLDNLANGEWRE 214
|
|
| PseudoU_synth_RluE |
cd02566 |
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins ... |
31-197 |
4.11e-104 |
|
Pseudouridine synthase, Escherichia coli RluE; This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. Escherichia coli RluE makes psi2457 in 23S RNA. psi2457 is not universally conserved.
Pssm-ID: 211334 [Multi-domain] Cd Length: 168 Bit Score: 296.99 E-value: 4.11e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 31 VVLFNKPYDVLPQFTDEA-GRSTLKDFIPLPGIYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGEPTA 109
Cdd:cd02566 1 LILFNKPYGVLSQFTDESeKHKTLKDYIDDPGVYAAGRLDRDSEGLLLLTDDGRLQHRITDPSFKHPKTYYVQVEGVPTE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 110 EALDALRTGVTLNDGPTLPAGIEVVEEPVWLWPRNPPIRERKNIPTSWLKVTLYEGRNRQVRRMTAHVGFPTLRLIRYAM 189
Cdd:cd02566 81 DALEQLRNGVELGDGLTLPAKVEKVDEPPWLWEREPPIRFRKNIPTSWIEITICEGKNRQVRRMTAAVGFPTLRLIRVSI 160
|
....*...
gi 489120937 190 GDYTLENL 197
Cdd:cd02566 161 GDIGLDNL 168
|
|
| TIGR00093 |
TIGR00093 |
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that ... |
65-205 |
1.26e-61 |
|
pseudouridine synthase; This model identifies panels of pseudouridine synthase enzymes that RNA modifications involved in maturing the protein translation apparatus. Counts per genome vary: two in Staphylococcus aureus, three in Pseudomonas putida, four in E. coli, etc. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 272902 Cd Length: 128 Bit Score: 187.92 E-value: 1.26e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 65 AGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGEPTAEALDALRTGVTLNDGPTLPAGIEVVEEPVWlwprn 144
Cdd:TIGR00093 1 VGRLDRDSEGLLLLTNDGELVHRLTHPGHHHEKEYLVTVEGPVTDEDLEALRKGVQLEDGKTKPAKLKVITEPGF----- 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489120937 145 ppirerkniPTsWLKVTLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYTLENLANGEWREL 205
Cdd:TIGR00093 76 ---------PT-WLRVTLSEGRNRQVRRMFAAVGFPVLRLHRVRIGDVSLNGLPPGEWRPL 126
|
|
| RsuA |
COG1187 |
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ... |
24-205 |
3.95e-61 |
|
Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 [Translation, ribosomal structure and biogenesis]; Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605 is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 440800 [Multi-domain] Cd Length: 226 Bit Score: 190.24 E-value: 3.95e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 24 KENQPKRVVLFNKPYDVLPQFTDEAGRSTLKDFIP---LPGIYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYY 100
Cdd:COG1187 57 KLPEEPVYLLLNKPAGVVSTTKDPEGRPTVFDLLPearKERLFPVGRLDKDTEGLLLLTNDGELAHRLTHPKYGVEKEYL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 101 VQVEGEPTAEALDALRTGVTLNDGPTLPAGIEVVeepvwlwprnppirerKNIPTSWLKVTLYEGRNRQVRRMTAHVGFP 180
Cdd:COG1187 137 VRVDGPVTEEDLERLREGVELEDGPTKPAKVEIL----------------SGEANTWLRITLTEGRNRQVRRMFEAVGLP 200
|
170 180
....*....|....*....|....*
gi 489120937 181 TLRLIRYAMGDYTLENLANGEWREL 205
Cdd:COG1187 201 VVRLKRVRIGPLTLGDLPPGEWREL 225
|
|
| PseudoU_synth_RsuA_like |
cd02870 |
Pseudouridine synthases, RsuA subfamily; Pseudouridine synthases are responsible for the ... |
31-188 |
1.52e-50 |
|
Pseudouridine synthases, RsuA subfamily; Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this family are bacterial proteins.
Pssm-ID: 211347 [Multi-domain] Cd Length: 146 Bit Score: 160.35 E-value: 1.52e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 31 VVLFNKPYDVLPQFTDEAGRSTLKDFIP--LPGIYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGEPT 108
Cdd:cd02870 1 YLLLNKPRGVVSTVRDPEGRPTVLDLLKdvGERLFPVGRLDYDTEGLLLLTNDGELANRLTHPRYGVEKTYLVKVRGVPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 109 AEALDALRTGVTLNDGPTLPAGIEVVEepvwlwprnppiRERKNiptSWLKVTLYEGRNRQVRRMTAHVGFPTLRLIRYA 188
Cdd:cd02870 81 EEELRRLRAGVELDDGKTAPAKVKVLS------------RDPKN---TLLEVTLHEGRNRQVRRMFEAVGHPVLRLKRVR 145
|
|
| PseudoU_synth_RsuA |
cd02553 |
Pseudouridine synthase, Escherichia coli RsuA like; This group is comprised of eukaryotic and ... |
30-205 |
1.20e-45 |
|
Pseudouridine synthase, Escherichia coli RsuA like; This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.
Pssm-ID: 211327 [Multi-domain] Cd Length: 167 Bit Score: 148.82 E-value: 1.20e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 30 RVVLFNKPYDVLPQFTDEAGRSTLkDFIP----LPGIYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEG 105
Cdd:cd02553 1 VYLMLNKPAGVVCATKDPHHPTVI-DLLPepdrRRDLFPVGRLDKDTTGLLLLTNDGQLAHRLTSPKKHVPKTYEVTLAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 106 EPTAEALDALRTGVTLNDG-PTLPAGIEVVEEpvwlwprnppirerkniptSWLKVTLYEGRNRQVRRMTAHVGFPTLRL 184
Cdd:cd02553 80 PLTEDDIEAFAEGVLLHDGyPTKPAKLEILSP-------------------TTVRLTITEGKYHQVKRMFAAVGNKVVAL 140
|
170 180
....*....|....*....|..
gi 489120937 185 IRYAMGDYTL-ENLANGEWREL 205
Cdd:cd02553 141 HRIRIGGLELdDDLAPGEWRPL 162
|
|
| PseudoU_synth_RluB |
cd02556 |
Pseudouridine synthase, Escherichia coli RluB like; This group is comprised of bacterial and ... |
30-207 |
8.06e-38 |
|
Pseudouridine synthase, Escherichia coli RluB like; This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RluB makes psi2605 in 23S RNA. psi2605 has been detected in eubacteria but, not in eukarya and archea despite the presence of a precursor U at that site.
Pssm-ID: 211330 [Multi-domain] Cd Length: 167 Bit Score: 128.58 E-value: 8.06e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 30 RVVLFNKPYDVLPQFTDEAGRSTLKDFIPLPGI---YAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGE 106
Cdd:cd02556 1 RVLIYHKPEGLICTRKDPKGRPTVFDLLPKLGIprwISVGRLDLNTEGLLLFTNDGELANRLMHPSNEIEREYAVRVFGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 107 PTAEALDALRTGVTLNDGPTLPAGIEVVEEpvwlwprnppirERKNiptSWLKVTLYEGRNRQVRRMTAHVGFPTLRLIR 186
Cdd:cd02556 81 VTDEQLKSLKKGVELEDGFAGFKSIQLEGG------------EGKN---SWYRVTLREGRNREVRRLWEAFGLQVSRLIR 145
|
170 180
....*....|....*....|..
gi 489120937 187 YAMGDYTL-ENLANGEWRELKS 207
Cdd:cd02556 146 IRYGPIFLpGNLKRGQWEELPP 167
|
|
| PseudoU_synth_Rsu_Rlu_like |
cd02550 |
Pseudouridine synthase, Rsu/Rlu family; This group is comprised of eukaryotic, bacterial and ... |
31-186 |
2.05e-32 |
|
Pseudouridine synthase, Rsu/Rlu family; This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and TruA. Pseudouridine synthases catalyze the isomerization of specific uridines in a n RNA molecule to pseudouridines (5-ribosyluracil, psi) requiring no cofactors. E. coli RluC for example makes psi955, 2504 and 2580 in 23S RNA. Some psi sites such as psi1917 in 23S RNA made by RluD are universally conserved. Other psi sites occur in a more restricted fashion, for example psi2819 in 21S mitochondrial ribosomal RNA made by S. cerevisiae Pus5p is only found in mitochondrial large subunit rRNAs from some other species and in gram negative bacteria. The E. coli counterpart of this psi residue is psi2580 in 23S rRNA. psi2604in 23S RNA made by RluF has only been detected in E.coli.
Pssm-ID: 211325 [Multi-domain] Cd Length: 154 Bit Score: 114.39 E-value: 2.05e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 31 VVLFNKPYDVLPQFTDEAGRSTLKDFIP---LPGIYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGEP 107
Cdd:cd02550 1 ILVLNKPSGLVCHPTDRDRDPTVVVRLDklhGPRVHAAGRLDKDTSGLLLLTNDGRLQRRLTEPRREIEKEYLVTVRGEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 108 TAEALDALRTGVTLND-------GPTLPAGIEVVEEpvwlwprnppirerkNIPTSWLKVTLYEGRNRQVRRMTAHVGFP 180
Cdd:cd02550 81 DEEGIEDLATVRRGRLsglvdegVPLAVTKVRVIGE---------------HGGTGRLRLTLKTGRTHQIRRHCAAVGFP 145
|
....*.
gi 489120937 181 TLRLIR 186
Cdd:cd02550 146 VLRLHR 151
|
|
| PseudoU_synth_RluF |
cd02554 |
Pseudouridine synthase, Escherichia coli RluF like; This group is comprised of bacterial ... |
33-205 |
1.22e-29 |
|
Pseudouridine synthase, Escherichia coli RluF like; This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RluF makes psi2604 in 23S RNA. psi2604 has only been detected in E. coli. It is absent from other eubacteria despite a precursor U at that site and from eukarya and archea which lack a precursor U at that site.
Pssm-ID: 211328 [Multi-domain] Cd Length: 164 Bit Score: 107.78 E-value: 1.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 33 LFNKPYDVLPQfTDEAGRSTLKDFI-PLPGIYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGEPTAEA 111
Cdd:cd02554 4 AYNKPVGIDCT-LERADEDNIIDFVnPPPRIFPIGRLDKDSEGLILLTNDGDLVNKILHADNNHEKEYLVTVNKPITDEF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 112 LDALRTGVTLNDGPTLPAGIEVVEEPVwlwprnppirerkniptswLKVTLYEGRNRQVRRMTAHVGFPTLRLIRYAMGD 191
Cdd:cd02554 83 IEGMSNGVVILGTVTKPCKVERLAKDK-------------------FRIVLTQGLNRQIRRMCEALGYRVTDLKRVRIMN 143
|
170
....*....|....
gi 489120937 192 YTLENLANGEWREL 205
Cdd:cd02554 144 IELGDLAPGEWRPL 157
|
|
| PRK10700 |
PRK10700 |
23S rRNA pseudouridine(2605) synthase RluB; |
13-205 |
2.93e-21 |
|
23S rRNA pseudouridine(2605) synthase RluB;
Pssm-ID: 182659 [Multi-domain] Cd Length: 289 Bit Score: 88.67 E-value: 2.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 13 RFSSRQVTKQRKENQPKRVVLFNKPYDVLPQFTDEAGRSTLKDFIP-LPGI--YAAGRLDRDSEGLLVLTNDGALQARLT 89
Cdd:PRK10700 51 RIDGHLISVKESAEQICRVLAYYKPEGELCTRNDPEGRPTVFDRLPkLRGArwIAVGRLDVNTCGLLLFTTDGELANRLM 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 90 QPGKRTGKIYYVQVEGEPTAEALDALRTGVTLNDGPTLPAGIEvveepvwlwprnppIRERKNIpTSWLKVTLYEGRNRQ 169
Cdd:PRK10700 131 HPSREVEREYAVRVFGQVDDAKLRQLSRGVQLEDGPAAFKTIK--------------FSGGEGI-NQWYNVTLTEGRNRE 195
|
170 180 190
....*....|....*....|....*....|....*..
gi 489120937 170 VRRMTAHVGFPTLRLIRYAMGDYTL-ENLANGEWREL 205
Cdd:PRK10700 196 VRRLWEAVGVQVSRLIRVRYGDIPLpKGLPRGGWTEL 232
|
|
| PSSA_1 |
cd02555 |
Pseudouridine synthase, a subgroup of the RsuA family; This group is comprised of bacterial ... |
58-205 |
8.36e-19 |
|
Pseudouridine synthase, a subgroup of the RsuA family; This group is comprised of bacterial proteins assigned to the RsuA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. The TruA family is comprised of proteins related to Escherichia coli RsuA.
Pssm-ID: 211329 [Multi-domain] Cd Length: 177 Bit Score: 79.76 E-value: 8.36e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 58 PLPG----IYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGEPTAEALDALRTGVTLNDGPTLPAGIEV 133
Cdd:cd02555 39 PLKGhfarLAPIGPLDKDASGLLVFSQDGRVLRKLIGDASRLEQEYLVEVRGELTAGGLERLNHGLTYDGRELPPAKVSW 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489120937 134 VEEpvwlwprnppirerkniptSWLKVTLYEGRNRQVRRMTAHVGFPTLRLIRYAMGDYTLENLANGEWREL 205
Cdd:cd02555 119 QNE-------------------QRLRFALKEPQPGQIRRMCESVGLEVVALRRIRIGRVSLGKLPLGQWRYL 171
|
|
| PRK10839 |
PRK10839 |
16S rRNA pseudouridine(516) synthase RsuA; |
30-205 |
1.13e-18 |
|
16S rRNA pseudouridine(516) synthase RsuA;
Pssm-ID: 236774 [Multi-domain] Cd Length: 232 Bit Score: 80.54 E-value: 1.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 30 RVVLFNKPYDVLPQfTDEAGRSTLKDFIPLPGIY---AAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGE 106
Cdd:PRK10839 61 RYFMLNKPQGYVCS-TDDPDHPTVLYFLDEPVAYklhAAGRLDIDTTGLVLMTDDGQWSHRITSPRHHCEKTYLVTLESP 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 107 PTAEALDALRTGVTLNDGPTL--PAGIEVVEEPVwlwprnppirerkniptswLKVTLYEGRNRQVRRMTAHVGFPTLRL 184
Cdd:PRK10839 140 VADDTAEQFAKGVQLHNEKDLtkPAVLEVITPTQ-------------------VRLTISEGRYHQVKRMFAAVGNHVVEL 200
|
170 180
....*....|....*....|..
gi 489120937 185 IRYAMGDYTL-ENLANGEWREL 205
Cdd:PRK10839 201 HRERIGAITLdADLAPGEYRPL 222
|
|
| PseudoU_synth_2 |
pfam00849 |
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA ... |
31-176 |
2.34e-18 |
|
RNA pseudouridylate synthase; Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA.
Pssm-ID: 459961 [Multi-domain] Cd Length: 151 Bit Score: 77.83 E-value: 2.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 31 VVLFNKPYDVLPQFTD-EAGRSTLKDFIPLPG-----IYAAGRLDRDSEGLLVLTNDGALQARLTQ--PGKRTGKIYYVQ 102
Cdd:pfam00849 1 YIVVNKPAGVPVHPTDsLTKLLSLLALLLRRElgvkrLYPVHRLDKNTSGLLLLAKDGEAANKLNKlfPERKIEKEYLAL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489120937 103 VEGEPTAEALDALRTGVTLNDGPTLPAGIEVVEEPVWLWprnPPIRERKNIPTSWLKVTLYEGRNRQVRRMTAH 176
Cdd:pfam00849 81 VDKPEEEEGTIKSPIKKEKNKSPFRKEEELGGKKAVTHL---KVLKSGSKGDYSLLELELVTGRKHQIRAHLAA 151
|
|
| PRK10475 |
PRK10475 |
23S rRNA pseudouridine(2604) synthase RluF; |
18-205 |
3.93e-18 |
|
23S rRNA pseudouridine(2604) synthase RluF;
Pssm-ID: 236698 [Multi-domain] Cd Length: 290 Bit Score: 80.16 E-value: 3.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 18 QVTKQRKENQPKRVVLfNKPYDVLPQfTDEAGRSTLKDFIPLPG-IYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTG 96
Cdd:PRK10475 57 QLIEPREAEDLVLIAL-NKPVGIVST-TEDGERDNIVDFVNHSKrVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHE 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 97 KIYYVQVEGEPTAEALDALRTGVtlndgPTLpaGIEVVEEPVwlwprnppireRKNIPTSWlKVTLYEGRNRQVRRMTAH 176
Cdd:PRK10475 135 KEYLVTVDKPITDEFIRGMGAGV-----PIL--GTVTKKCKV-----------KKEAPFVF-RITLVQGLNRQIRRMCEH 195
|
170 180
....*....|....*....|....*....
gi 489120937 177 VGFPTLRLIRYAMGDYTLENLANGEWREL 205
Cdd:PRK10475 196 FGYEVTKLERTRIMNVSLSGIPLGEWRDL 224
|
|
| PseudoU_synth_TruC |
cd02563 |
tRNA pseudouridine isomerase C; Pseudouridine synthases catalyze the isomerization of specific ... |
62-182 |
6.14e-04 |
|
tRNA pseudouridine isomerase C; Pseudouridine synthases catalyze the isomerization of specific uridines in an tRNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. TruC makes psi65 in tRNAs. This psi residue is not universally conserved.
Pssm-ID: 211333 [Multi-domain] Cd Length: 223 Bit Score: 39.24 E-value: 6.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489120937 62 IYAAGRLDRDSEGLLVLTNDGALQARLTQ--PGKRTGKIYYVQVEGEPTAEALDALRTGVTLNDGPTLPAGIEVVEEPVW 139
Cdd:cd02563 46 VYPVHRLDRPTSGVLLFALSSEVARKLGEqfTEHRVHKTYLAVVRGYVPESGTIDYPLSEELDKLADKFASDDKAPQAAT 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 489120937 140 LWPR-----NPPIRERKnIPT---SWLKVTLYEGRNRQVRRMTAHVGFPTL 182
Cdd:cd02563 126 THYRllaveELPVVVGK-YPTsrySLVELTPHTGRKHQLRRHLAHIRHPII 175
|
|
| |
