|
Name |
Accession |
Description |
Interval |
E-value |
| frlB |
PRK11382 |
fructoselysine 6-phosphate deglycase; |
42-339 |
6.68e-23 |
|
fructoselysine 6-phosphate deglycase;
Pssm-ID: 183111 [Multi-domain] Cd Length: 340 Bit Score: 97.38 E-value: 6.68e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 42 RPLKDIYFVGCGGSFSSSVHAHALLCRHSKkLQAWNLNAAEFMAQPPARLGASSLVILSSHSGATPETAQAALFAKSYDA 121
Cdd:PRK11382 42 RDIDRIYFVACGSPLNAAQTAKHLADRFSD-LQVYAISGWEFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALELGRACGA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 122 YVVSLSQELNTPLANTADTALVYYSPRTVTPGKQLLLLQLVIELLEHVDNLDVSAWRDALPALPAALQQYLDKQEAVGDA 201
Cdd:PRK11382 121 LTAAFTKRADSPITSAAEFSIDYQADCIWEIHLLLCYSVVLEMITRLAPNAEIGKIKNDLKQLPNALGHLVRTWEEKGRQ 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 202 IAKSIAQGGDIYVTAAGANYGAAYTLSYCYLMEMQWRNATPVLAGDFCHGPFEMILPGAHLVVFHADDDSRAMTQRAIDF 281
Cdd:PRK11382 201 LGELASQWPMIYTVAAGPLRPLGYKEGIVTLMEFTWTHGCVIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINF 280
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 489122138 282 ARRYTENVHVFDAAGFSlPGAAPEVKARFAAIALglmgTRLADHLEHHTGHSLDDRRY 339
Cdd:PRK11382 281 VKQRTDNVIVIDYAEIS-QGLHPWLAPFLMFVPM----EWLCYYLSIYKDHNPDERRY 333
|
|
| SIS_1 |
cd05710 |
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ... |
47-144 |
7.89e-23 |
|
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 240214 [Multi-domain] Cd Length: 120 Bit Score: 91.87 E-value: 7.89e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 47 IYFVGCGGSFSSSVHAHALLCRHSKkLQAWNLNAAEFMAQPPARLGASSLVILSSHSGATPETAQAALFAKSYDAYVVSL 126
Cdd:cd05710 2 VFFVGCGGSLADMYPAKYFLKKESK-LPVFVYNAAEFLHTGPKRLTEKSVVILASHSGNTKETVAAAKFAKEKGATVIGL 80
|
90
....*....|....*...
gi 489122138 127 SQELNTPLANTADTALVY 144
Cdd:cd05710 81 TDDEDSPLAKLADYVIVY 98
|
|
| AgaS |
COG2222 |
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ... |
47-343 |
1.26e-19 |
|
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441824 [Multi-domain] Cd Length: 336 Bit Score: 88.03 E-value: 1.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 47 IYFVGCGGSFSSSVHAHALLCRHSKkLQAWNLNAAEFMAQPPARLGASSLVILSSHSGATPETAQAALFAKSYDAYVVSL 126
Cdd:COG2222 37 VVLVGAGSSDHAAQAAAYLLERLLG-IPVAALAPSELVVYPAYLKLEGTLVVAISRSGNSPEVVAALELAKARGARTLAI 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 127 SQELNTPLANTADTALV-YYSP-------RTVTpgkqllllQLVIELLEHVDNL-DVSAWRDALPALPAALQQYLDKQEA 197
Cdd:COG2222 116 TNNPDSPLAEAADRVLPlPAGPeksvaatKSFT--------TMLLALLALLAAWgGDDALLAALDALPAALEAALAADWP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 198 VGDAIAksIAQGGDIYVTAAganygaaytlSYCY---------LMEMQWRNATPVLAGDFCHGPFEMILPGAHLVVFHAD 268
Cdd:COG2222 188 AAALAA--LADAERVVFLGR----------GPLYglareaalkLKELSAGHAEAYSAAEFRHGPKSLVDPGTLVVVLASE 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489122138 269 DDSRAMTQRAIDFARRYTENVHVFDAAG---FSLPgAAPEVKARFAAIALGLMGTRLADHLEHHTGHSLDDRRYMYKV 343
Cdd:COG2222 256 DPTRELDLDLAAELRALGARVVAIGAEDdaaITLP-AIPDLHDALDPLLLLVVAQRLALALALARGLDPDTPRHLNKV 332
|
|
| SIS |
pfam01380 |
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
45-142 |
5.55e-08 |
|
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.
Pssm-ID: 426230 [Multi-domain] Cd Length: 131 Bit Score: 51.15 E-value: 5.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 45 KDIYFVGCGGSFSSSVHAHALLCRHSKKLQAWNLnAAEFMAQPPARLGASSLVILSSHSGATPETAQAALFAKSYDAYVV 124
Cdd:pfam01380 6 KRIFVIGRGTSYAIALELALKFEEIGYKVVEVEL-ASELRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARGAKII 84
|
90
....*....|....*...
gi 489122138 125 SLSQELNTPLANTADTAL 142
Cdd:pfam01380 85 AITDSPGSPLAREADHVL 102
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| frlB |
PRK11382 |
fructoselysine 6-phosphate deglycase; |
42-339 |
6.68e-23 |
|
fructoselysine 6-phosphate deglycase;
Pssm-ID: 183111 [Multi-domain] Cd Length: 340 Bit Score: 97.38 E-value: 6.68e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 42 RPLKDIYFVGCGGSFSSSVHAHALLCRHSKkLQAWNLNAAEFMAQPPARLGASSLVILSSHSGATPETAQAALFAKSYDA 121
Cdd:PRK11382 42 RDIDRIYFVACGSPLNAAQTAKHLADRFSD-LQVYAISGWEFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALELGRACGA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 122 YVVSLSQELNTPLANTADTALVYYSPRTVTPGKQLLLLQLVIELLEHVDNLDVSAWRDALPALPAALQQYLDKQEAVGDA 201
Cdd:PRK11382 121 LTAAFTKRADSPITSAAEFSIDYQADCIWEIHLLLCYSVVLEMITRLAPNAEIGKIKNDLKQLPNALGHLVRTWEEKGRQ 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 202 IAKSIAQGGDIYVTAAGANYGAAYTLSYCYLMEMQWRNATPVLAGDFCHGPFEMILPGAHLVVFHADDDSRAMTQRAIDF 281
Cdd:PRK11382 201 LGELASQWPMIYTVAAGPLRPLGYKEGIVTLMEFTWTHGCVIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINF 280
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 489122138 282 ARRYTENVHVFDAAGFSlPGAAPEVKARFAAIALglmgTRLADHLEHHTGHSLDDRRY 339
Cdd:PRK11382 281 VKQRTDNVIVIDYAEIS-QGLHPWLAPFLMFVPM----EWLCYYLSIYKDHNPDERRY 333
|
|
| SIS_1 |
cd05710 |
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ... |
47-144 |
7.89e-23 |
|
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 240214 [Multi-domain] Cd Length: 120 Bit Score: 91.87 E-value: 7.89e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 47 IYFVGCGGSFSSSVHAHALLCRHSKkLQAWNLNAAEFMAQPPARLGASSLVILSSHSGATPETAQAALFAKSYDAYVVSL 126
Cdd:cd05710 2 VFFVGCGGSLADMYPAKYFLKKESK-LPVFVYNAAEFLHTGPKRLTEKSVVILASHSGNTKETVAAAKFAKEKGATVIGL 80
|
90
....*....|....*...
gi 489122138 127 SQELNTPLANTADTALVY 144
Cdd:cd05710 81 TDDEDSPLAKLADYVIVY 98
|
|
| AgaS |
COG2222 |
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ... |
47-343 |
1.26e-19 |
|
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441824 [Multi-domain] Cd Length: 336 Bit Score: 88.03 E-value: 1.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 47 IYFVGCGGSFSSSVHAHALLCRHSKkLQAWNLNAAEFMAQPPARLGASSLVILSSHSGATPETAQAALFAKSYDAYVVSL 126
Cdd:COG2222 37 VVLVGAGSSDHAAQAAAYLLERLLG-IPVAALAPSELVVYPAYLKLEGTLVVAISRSGNSPEVVAALELAKARGARTLAI 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 127 SQELNTPLANTADTALV-YYSP-------RTVTpgkqllllQLVIELLEHVDNL-DVSAWRDALPALPAALQQYLDKQEA 197
Cdd:COG2222 116 TNNPDSPLAEAADRVLPlPAGPeksvaatKSFT--------TMLLALLALLAAWgGDDALLAALDALPAALEAALAADWP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 198 VGDAIAksIAQGGDIYVTAAganygaaytlSYCY---------LMEMQWRNATPVLAGDFCHGPFEMILPGAHLVVFHAD 268
Cdd:COG2222 188 AAALAA--LADAERVVFLGR----------GPLYglareaalkLKELSAGHAEAYSAAEFRHGPKSLVDPGTLVVVLASE 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489122138 269 DDSRAMTQRAIDFARRYTENVHVFDAAG---FSLPgAAPEVKARFAAIALGLMGTRLADHLEHHTGHSLDDRRYMYKV 343
Cdd:COG2222 256 DPTRELDLDLAAELRALGARVVAIGAEDdaaITLP-AIPDLHDALDPLLLLVVAQRLALALALARGLDPDTPRHLNKV 332
|
|
| SIS_RpiR |
cd05013 |
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ... |
47-147 |
6.94e-11 |
|
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.
Pssm-ID: 240144 [Multi-domain] Cd Length: 139 Bit Score: 59.55 E-value: 6.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 47 IYFVGCGGSFSSSVHAHALLCRHSKKLQAwnLNAAEFMAQPPARLGASSLVILSSHSGATPETAQAALFAKSYDAYVVSL 126
Cdd:cd05013 16 IYIFGVGSSGLVAEYLAYKLLRLGKPVVL--LSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAAEIAKERGAKVIAI 93
|
90 100
....*....|....*....|.
gi 489122138 127 SQELNTPLANTADTALVYYSP 147
Cdd:cd05013 94 TDSANSPLAKLADIVLLVSSE 114
|
|
| RpiR |
COG1737 |
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ... |
47-147 |
2.76e-10 |
|
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];
Pssm-ID: 441343 [Multi-domain] Cd Length: 286 Bit Score: 60.33 E-value: 2.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 47 IYFVGCGGSFSSSVHAHALLCRHSKKLQAWNLNAAEFMAQPpARLGASSLVILSSHSGATPETAQAALFAKSYDAYVVSL 126
Cdd:COG1737 137 IYIFGVGASAPVAEDLAYKLLRLGKNVVLLDGDGHLQAESA-ALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAI 215
|
90 100
....*....|....*....|.
gi 489122138 127 SQELNTPLANTADTALVYYSP 147
Cdd:COG1737 216 TDSPLSPLAKLADVVLYVPSE 236
|
|
| SIS |
pfam01380 |
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
45-142 |
5.55e-08 |
|
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.
Pssm-ID: 426230 [Multi-domain] Cd Length: 131 Bit Score: 51.15 E-value: 5.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 45 KDIYFVGCGGSFSSSVHAHALLCRHSKKLQAWNLnAAEFMAQPPARLGASSLVILSSHSGATPETAQAALFAKSYDAYVV 124
Cdd:pfam01380 6 KRIFVIGRGTSYAIALELALKFEEIGYKVVEVEL-ASELRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARGAKII 84
|
90
....*....|....*...
gi 489122138 125 SLSQELNTPLANTADTAL 142
Cdd:pfam01380 85 AITDSPGSPLAREADHVL 102
|
|
| SIS_GlmS_GlmD_2 |
cd05009 |
SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and ... |
232-343 |
1.11e-06 |
|
SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.
Pssm-ID: 240142 [Multi-domain] Cd Length: 153 Bit Score: 47.64 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 232 LMEMQWRNATPVLAGDFCHGPFEMILPGAHLVVFHADDDSRAMTQRAIDFARRYTENVHVFDAAG---------FSLPGA 302
Cdd:cd05009 35 LKETSYIHAEAYSAGEFKHGPIALVDEGTPVIFLAPEDRLEEKLESLIKEVKARGAKVIVITDDGdakdladvvIRVPAT 114
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 489122138 303 APEVKARFAAIALGLMGTRLADHLehhtGHSLDDRRYMYKV 343
Cdd:cd05009 115 VEELSPLLYIVPLQLLAYHLAVAR----GIDPDKPRNLAKS 151
|
|
| SIS |
cd04795 |
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
47-127 |
3.04e-05 |
|
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 240112 [Multi-domain] Cd Length: 87 Bit Score: 41.98 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 47 IYFVGCGGSFSSSVHAhALLCRHSKKLQAWNLNAAEFMAQPPARLGAS-SLVILSSHSGATPETAQAALFAKSYDAYVVS 125
Cdd:cd04795 1 IFVIGIGGSGAIAAYF-ALELLELTGIEVVALIATELEHASLLSLLRKgDVVIALSYSGRTEELLAALEIAKELGIPVIA 79
|
..
gi 489122138 126 LS 127
Cdd:cd04795 80 IT 81
|
|
| SIS_GlmS_GlmD_1 |
cd05008 |
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ... |
47-143 |
3.22e-03 |
|
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.
Pssm-ID: 240141 [Multi-domain] Cd Length: 126 Bit Score: 37.09 E-value: 3.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489122138 47 IYFVGCGGSFSSSVHAHALLCRHSK-KLQAwnLNAAEF-MAQPParLGASSLVILSSHSGATPETAQAALFAKSYDAYVV 124
Cdd:cd05008 2 ILIVGCGTSYHAALVAKYLLERLAGiPVEV--EAASEFrYRRPL--LDEDTLVIAISQSGETADTLAALRLAKEKGAKTV 77
|
90
....*....|....*....
gi 489122138 125 SLSQELNTPLANTADTALV 143
Cdd:cd05008 78 AITNVVGSTLAREADYVLY 96
|
|
| |
