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Conserved domains on  [gi|489125419|ref|WP_003035216|]
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MULTISPECIES: transcriptional regulator CecR [Citrobacter]

Protein Classification

transcriptional regulator( domain architecture ID 11485390)

HTH-type transcriptional regulator CecR/YbiH regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
1-224 3.39e-154

putative DNA-binding transcriptional regulator; Provisional


:

Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 426.78  E-value: 3.39e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419   1 MNTPTMTTKGEQAKNQLIAAALAQFGEYGLHATTRDIAAQAGQNIAAITYYFGSKEDLYLACAQWIADFIGSQFRPHAEE 80
Cdd:PRK11552   2 MNNPAMTTRGEQAKQQLIAAALAQFGEYGLHATTRDIAAQAGQNIAAITYYFGSKEDLYLAVAQWIADFIGEQFRPHAEE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419  81 AERLFAQPEPDRGAMRELILRACKNMIMLLTQDDTVNLSKFISREQLSPTAAYQLVHDQVINPLHTHLTRLIAAYTGGDA 160
Cdd:PRK11552  82 AERLFAQPAPDRAAIRELILRACLNMIKLLTQDDTVNLSKFISREQLSPTAAYHLIHEQVISPLHSHLTRLIAAYTGCDA 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489125419 161 NDTQMILHTHAILGEVLAFRLGKETILLRTGWSQFDEDKTALIDQTITCHIDLILQGLTQRSLE 224
Cdd:PRK11552 162 NDTRTILHTHALIGEVLAFRLGRETILLRTGWTQFDEEKAELINQVVTCHIDLILNGLRQRSLD 225
 
Name Accession Description Interval E-value
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
1-224 3.39e-154

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 426.78  E-value: 3.39e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419   1 MNTPTMTTKGEQAKNQLIAAALAQFGEYGLHATTRDIAAQAGQNIAAITYYFGSKEDLYLACAQWIADFIGSQFRPHAEE 80
Cdd:PRK11552   2 MNNPAMTTRGEQAKQQLIAAALAQFGEYGLHATTRDIAAQAGQNIAAITYYFGSKEDLYLAVAQWIADFIGEQFRPHAEE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419  81 AERLFAQPEPDRGAMRELILRACKNMIMLLTQDDTVNLSKFISREQLSPTAAYQLVHDQVINPLHTHLTRLIAAYTGGDA 160
Cdd:PRK11552  82 AERLFAQPAPDRAAIRELILRACLNMIKLLTQDDTVNLSKFISREQLSPTAAYHLIHEQVISPLHSHLTRLIAAYTGCDA 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489125419 161 NDTQMILHTHAILGEVLAFRLGKETILLRTGWSQFDEDKTALIDQTITCHIDLILQGLTQRSLE 224
Cdd:PRK11552 162 NDTRTILHTHALIGEVLAFRLGRETILLRTGWTQFDEEKAELINQVVTCHIDLILNGLRQRSLD 225
CecR_C pfam09209
HTH-type transcriptional dual regulator CecR, C-terminal domain; This entry represents the ...
96-218 1.98e-39

HTH-type transcriptional dual regulator CecR, C-terminal domain; This entry represents the C-terminal domain found in CecR (regulator of cefoperazone and chloramphenicol sensitivity), previously known as YbiH. CecR has been shown to control sensitivity to cefoperazone and chloramphenicol through regulating the transcription of the cecR-ybhGFSR operon and the rhlE gene.


Pssm-ID: 430467  Cd Length: 125  Bit Score: 132.02  E-value: 1.98e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419   96 RELILRACKNMI-MLLTQDDTVNLSKFISREQLSPTAAYQLVHDQVINPLHTHLTRLIAAYTGGDANDTQMILHTHAILG 174
Cdd:pfam09209   2 RERLRAFIRRMLaRIASEDEPEWWGRFMAREQAEPTGALDRIYKGVIKPLHAALCRIVAELLGEDADDESVRLCTLSIVG 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 489125419  175 EVLAFRLGKETILLRTGWSQFDEDKTALIDQTITCHIDLILQGL 218
Cdd:pfam09209  82 QCLHFRVAREAVLRLLGWLTFDPEEIDDIAALAEHILRFSLAGL 125
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
7-86 9.23e-13

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 63.76  E-value: 9.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419   7 TTKGEQAKNQLIAAALAQFGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLYLACAQWIADFIGSQFRPHAEE---AE 82
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSvRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAedpRE 80

                 ....
gi 489125419  83 RLFA 86
Cdd:COG1309   81 RLRA 84
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
14-125 6.44e-09

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 53.69  E-value: 6.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419  14 KNQLIAAALAQFGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLYLACaqwIADFigsqFRPHAEEAERLFAQPEPdR 92
Cdd:NF037937   1 KEKILDAAISLFNTKGFDGTSvRDIAKKAKVNVALISYYFKGKQGLLEYL---VTSF----FEGYLEILEEGFEELKN-L 72
                         90       100       110
                 ....*....|....*....|....*....|...
gi 489125419  93 GAMrELILRACKNMIMLltQDDTVNLSKFISRE 125
Cdd:NF037937  73 SAK-ECLKQLVRNILHY--QQEHHQLTRFVHRE 102
 
Name Accession Description Interval E-value
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
1-224 3.39e-154

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 426.78  E-value: 3.39e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419   1 MNTPTMTTKGEQAKNQLIAAALAQFGEYGLHATTRDIAAQAGQNIAAITYYFGSKEDLYLACAQWIADFIGSQFRPHAEE 80
Cdd:PRK11552   2 MNNPAMTTRGEQAKQQLIAAALAQFGEYGLHATTRDIAAQAGQNIAAITYYFGSKEDLYLAVAQWIADFIGEQFRPHAEE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419  81 AERLFAQPEPDRGAMRELILRACKNMIMLLTQDDTVNLSKFISREQLSPTAAYQLVHDQVINPLHTHLTRLIAAYTGGDA 160
Cdd:PRK11552  82 AERLFAQPAPDRAAIRELILRACLNMIKLLTQDDTVNLSKFISREQLSPTAAYHLIHEQVISPLHSHLTRLIAAYTGCDA 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489125419 161 NDTQMILHTHAILGEVLAFRLGKETILLRTGWSQFDEDKTALIDQTITCHIDLILQGLTQRSLE 224
Cdd:PRK11552 162 NDTRTILHTHALIGEVLAFRLGRETILLRTGWTQFDEEKAELINQVVTCHIDLILNGLRQRSLD 225
CecR_C pfam09209
HTH-type transcriptional dual regulator CecR, C-terminal domain; This entry represents the ...
96-218 1.98e-39

HTH-type transcriptional dual regulator CecR, C-terminal domain; This entry represents the C-terminal domain found in CecR (regulator of cefoperazone and chloramphenicol sensitivity), previously known as YbiH. CecR has been shown to control sensitivity to cefoperazone and chloramphenicol through regulating the transcription of the cecR-ybhGFSR operon and the rhlE gene.


Pssm-ID: 430467  Cd Length: 125  Bit Score: 132.02  E-value: 1.98e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419   96 RELILRACKNMI-MLLTQDDTVNLSKFISREQLSPTAAYQLVHDQVINPLHTHLTRLIAAYTGGDANDTQMILHTHAILG 174
Cdd:pfam09209   2 RERLRAFIRRMLaRIASEDEPEWWGRFMAREQAEPTGALDRIYKGVIKPLHAALCRIVAELLGEDADDESVRLCTLSIVG 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 489125419  175 EVLAFRLGKETILLRTGWSQFDEDKTALIDQTITCHIDLILQGL 218
Cdd:pfam09209  82 QCLHFRVAREAVLRLLGWLTFDPEEIDDIAALAEHILRFSLAGL 125
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
7-86 9.23e-13

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 63.76  E-value: 9.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419   7 TTKGEQAKNQLIAAALAQFGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLYLACAQWIADFIGSQFRPHAEE---AE 82
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSvRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAedpRE 80

                 ....
gi 489125419  83 RLFA 86
Cdd:COG1309   81 RLRA 84
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
5-102 1.06e-12

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 64.19  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419   5 TMTTKGEQAKNQLIAAALAQFGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLYLACAQWIADFIGSQFRPHAEEAER 83
Cdd:COG3226    1 PRRRRGEERRERILEAALRVIARDGVRGVThRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADD 80
                         90
                 ....*....|....*....
gi 489125419  84 lfaqPEPDRGAMRELILRA 102
Cdd:COG3226   81 ----LEDAAEALADLLAEL 95
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
17-62 1.12e-11

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 57.80  E-value: 1.12e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 489125419   17 LIAAALAQFGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLYLAC 62
Cdd:pfam00440   1 ILDAARELFAERGYDATTvREIAKRAGVSKGALYRYFGSKEELLEAL 47
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
14-125 6.44e-09

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 53.69  E-value: 6.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419  14 KNQLIAAALAQFGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLYLACaqwIADFigsqFRPHAEEAERLFAQPEPdR 92
Cdd:NF037937   1 KEKILDAAISLFNTKGFDGTSvRDIAKKAKVNVALISYYFKGKQGLLEYL---VTSF----FEGYLEILEEGFEELKN-L 72
                         90       100       110
                 ....*....|....*....|....*....|...
gi 489125419  93 GAMrELILRACKNMIMLltQDDTVNLSKFISRE 125
Cdd:NF037937  73 SAK-ECLKQLVRNILHY--QQEHHQLTRFVHRE 102
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
3-89 6.71e-07

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 48.39  E-value: 6.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489125419   3 TPTMTTKGEQAKNQLI-AAALAQFGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLYLACAQWIADFIGSQFRPHAEE 80
Cdd:PRK15008   8 TTGKRSRAVSAKKKAIlSAALDTFSQFGFHGTRlEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLKAFRED 87

                 ....*....
gi 489125419  81 AERLFAQPE 89
Cdd:PRK15008  88 FAPLAAIKE 96
PRK00767 PRK00767
transcriptional regulator BetI; Validated
16-62 4.90e-06

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 45.60  E-value: 4.90e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 489125419  16 QLIAAALAQFGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLYLAC 62
Cdd:PRK00767  13 QLIDATLRAIGEVGLLDATiAQIARRAGVSTGIISHYFGGKDGLLEAT 60
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
8-59 1.00e-03

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 38.95  E-value: 1.00e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489125419   8 TKGEQAK--NQLIAAALAQFGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLY 59
Cdd:PRK09975   5 TKAEALKtrQELIETAIAQFALRGVSNTTlNDIADAANVTRGAIYWHFENKTQLF 59
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
11-59 3.54e-03

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 37.29  E-value: 3.54e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 489125419  11 EQAKNQLIAAALAQFGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLY 59
Cdd:PRK10668  10 QETRQHILDAALRLFSQQGVSATSlADIAKAAGVTRGAIYWHFKNKSDLF 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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