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Conserved domains on  [gi|489127508|ref|WP_003037300|]
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MULTISPECIES: multidrug efflux transporter EmrAB transcriptional repressor EmrR [Citrobacter]

Protein Classification

transcriptional repressor MprA( domain architecture ID 10013668)

transcriptional repressor MprA functions as a negative regulator of the multidrug operon emrAB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 1-176 1.97e-124

transcriptional repressor MprA; Provisional


:

Pssm-ID: 182795  Cd Length: 176  Bit Score: 347.51  E-value: 1.97e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508   1 MDSSFTPIEQMLKFRASRYEEFPYQEVLLTRLCMHMQGKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCA 80
Cdd:PRK10870   1 MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508  81 LGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHAFLQEVLPPQHNCLHQLWSSLSTTEKDQLEQITRKLLT 160
Cdd:PRK10870  81 LGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLS 160

                        170
                 ....*....|....*.
gi 489127508 161 RLDQMEQDGAVLEALR 176
Cdd:PRK10870 161 RLDQMEQDGVVLEAMS 176
 
Name Accession Description Interval E-value
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 1-176 1.97e-124

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 347.51  E-value: 1.97e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508   1 MDSSFTPIEQMLKFRASRYEEFPYQEVLLTRLCMHMQGKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCA 80
Cdd:PRK10870   1 MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508  81 LGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHAFLQEVLPPQHNCLHQLWSSLSTTEKDQLEQITRKLLT 160
Cdd:PRK10870  81 LGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLS 160

                        170
                 ....*....|....*.
gi 489127508 161 RLDQMEQDGAVLEALR 176
Cdd:PRK10870 161 RLDQMEQDGVVLEAMS 176
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
46-148 3.86e-26

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 95.74  E-value: 3.86e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508    46 KMLKAQGINETLFMALITLESQEnhSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHAFL 125
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEG--PLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELI 78

                           90       100
                   ....*....|....*....|...
gi 489127508   126 QEVLPPQHNCLHQLWSSLSTTEK 148
Cdd:smart00347  79 EQLLEARSETLAELLAGLTAEEQ 101
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
29-161 1.28e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.41  E-value: 1.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508  29 LTRLCMHMQGKLLENRNKMLKAQGINETLFMALITLESQEnhSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDN 108
Cdd:COG1846   12 LGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAG--GLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489127508 109 DRRCLHLQLTEKGHAFLQEVLPPQHNCLHQLWSSLSTTEKDQLEQITRKLLTR 161
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 53-112 3.06e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 58.71  E-value: 3.06e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508   53 INETLFMALITLESQENHSIqpSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRC 112
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTV--SELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
 
Name Accession Description Interval E-value
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 1-176 1.97e-124

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 347.51  E-value: 1.97e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508   1 MDSSFTPIEQMLKFRASRYEEFPYQEVLLTRLCMHMQGKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCA 80
Cdd:PRK10870   1 MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508  81 LGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHAFLQEVLPPQHNCLHQLWSSLSTTEKDQLEQITRKLLT 160
Cdd:PRK10870  81 LGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLS 160

                        170
                 ....*....|....*.
gi 489127508 161 RLDQMEQDGAVLEALR 176
Cdd:PRK10870 161 RLDQMEQDGVVLEAMS 176
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
46-148 3.86e-26

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 95.74  E-value: 3.86e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508    46 KMLKAQGINETLFMALITLESQEnhSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHAFL 125
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEG--PLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELI 78

                           90       100
                   ....*....|....*....|...
gi 489127508   126 QEVLPPQHNCLHQLWSSLSTTEK 148
Cdd:smart00347  79 EQLLEARSETLAELLAGLTAEEQ 101
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
29-161 1.28e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.41  E-value: 1.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508  29 LTRLCMHMQGKLLENRNKMLKAQGINETLFMALITLESQEnhSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDN 108
Cdd:COG1846   12 LGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAG--GLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489127508 109 DRRCLHLQLTEKGHAFLQEVLPPQHNCLHQLWSSLSTTEKDQLEQITRKLLTR 161
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 53-112 3.06e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 58.71  E-value: 3.06e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508   53 INETLFMALITLESQENHSIqpSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRC 112
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTV--SELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
45-159 3.30e-08

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 49.90  E-value: 3.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508  45 NKMLKAQGINETLFMALITLESQEnhSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHAF 124
Cdd:PRK11512  30 NEYLSPLDITAAQFKVLCSIRCAA--CITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAI 107

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489127508 125 LQEVLPPQHNCLHQ-LWSSLSTTEKDQLEQITRKLL 159
Cdd:PRK11512 108 CEQCHQLVGQDLHQeLTKNLTADEVATLEHLLKKVL 143
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 58-111 1.58e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 43.35  E-value: 1.58e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489127508   58 FMALITLESQENHSiqPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRR 111
Cdd:pfam12802   8 FRVLLALARNPGLT--VAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 76-158 9.24e-05

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 40.37  E-value: 9.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508  76 ELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHAFLQEVLPPQHNCLHQLWSSLSTTEKDQLEQIT 155
Cdd:PRK03573  51 QLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIEQLITLI 130


                 ...
gi 489127508 156 RKL 158
Cdd:PRK03573 131 AKL 133
Rfk COG1339
Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal ...
 75-129 2.46e-04

Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal CTP-dependent riboflavin kinase is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


Pssm-ID: 440950 [Multi-domain]  Cd Length: 219  Bit Score: 40.21  E-value: 2.46e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489127508  75 SELSCALGSSRTNATRIADELEKRGWIERRESdndRRCLHLQLTEKGHAFLQEVL 129
Cdd:COG1339   26 SELAKRLGISQQTASRRLQELEDAGLIERDLV---GDGQWVKITEKGEELLRREY 77
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
74-130 3.69e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 36.80  E-value: 3.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489127508  74 PSELSCALGSSRTNATRIADELEKRGWIERRESdndrrclHLQLTEKGHAFLQEVLP 130
Cdd:COG4742   32 RSELAESLDVSRSTILRQLKELEERGLIERDDG-------EYELTTLGRLVVEEMEP 81
pheS PRK04172
phenylalanine--tRNA ligase subunit alpha;
67-160 8.91e-03

phenylalanine--tRNA ligase subunit alpha;


Pssm-ID: 235239 [Multi-domain]  Cd Length: 489  Bit Score: 35.96  E-value: 8.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127508  67 QENHSIQPSELSCALGSSRTNATRIADELEKRGWIE-RRESDNdrrclHLQLTEKGHAFLQEVLPPqhnclHQLWSSLST 145
Cdd:PRK04172  16 KELKEATLEELAEKLGLPPEAVMRAAEWLEEKGLVKvEERVEE-----VYVLTEEGKKYAEEGLPE-----RRLLNALKD 85

                         90
                 ....*....|....*
gi 489127508 146 TEKDQLEQITRKLLT 160
Cdd:PRK04172  86 GGEVSLDELKEALLD 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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