NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489148503|ref|WP_003058235|]
View 

MULTISPECIES: NAD glycohydrolase inhibitor [Streptococcus]

Protein Classification

NAD glycohydrolase inhibitor( domain architecture ID 11245209)

NAD glycohydrolase inhibitor such as Streptococcus pyogenes endogenous immunity factor for SPN (IFS), which inhibits the toxin beta-NAD(+) glycohydrolase (SPN) in the bacteria; SPN is injected into the cytosol of a host cell using the cytolysin-mediated translocation pathway

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IFS pfam16718
Immunity factor for SPN; Immunity factor for SPN (IFS) binds to and inhibits the SPN toxin.
 1-161 2.14e-74

Immunity factor for SPN; Immunity factor for SPN (IFS) binds to and inhibits the SPN toxin.


:

Pssm-ID: 374750  Cd Length: 164  Bit Score: 219.90  E-value: 2.14e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489148503    1 MYKVPKGLEHYQKMFQKEVTVNDLKKYLIGSDKEYRITKRDSYMGDISDPEVILEYGIYPAFIKGYTQLKANIEEALLEM 80
Cdd:pfam16718   1 MYKNPKGYEHYVKLYLKAMSEGKEAEAFLGTDKKYRITQRDSYMQDITDIEVLLEYCLYPLYVEGDTDIKRRTFEILKEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489148503   81 SNSGQALDIYQAVQTLNAENMLLNYYESLPFYLNRQSILANITKA---LKDAHIREAMAHYKLGEFAHYQDTMLDMVERT 157
Cdd:pfam16718  81 SLSNDLIKLYQVVQYINIQNMLLNYYESLPFYIDTDPIVPNIKESiskLSDEQKRTYMYTYLCGEFAHYKDCMFDKVERI 160


                  ....
gi 489148503  158 IETF 161
Cdd:pfam16718 161 LKEF 164
 
Name Accession Description Interval E-value
IFS pfam16718
Immunity factor for SPN; Immunity factor for SPN (IFS) binds to and inhibits the SPN toxin.
 1-161 2.14e-74

Immunity factor for SPN; Immunity factor for SPN (IFS) binds to and inhibits the SPN toxin.


Pssm-ID: 374750  Cd Length: 164  Bit Score: 219.90  E-value: 2.14e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489148503    1 MYKVPKGLEHYQKMFQKEVTVNDLKKYLIGSDKEYRITKRDSYMGDISDPEVILEYGIYPAFIKGYTQLKANIEEALLEM 80
Cdd:pfam16718   1 MYKNPKGYEHYVKLYLKAMSEGKEAEAFLGTDKKYRITQRDSYMQDITDIEVLLEYCLYPLYVEGDTDIKRRTFEILKEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489148503   81 SNSGQALDIYQAVQTLNAENMLLNYYESLPFYLNRQSILANITKA---LKDAHIREAMAHYKLGEFAHYQDTMLDMVERT 157
Cdd:pfam16718  81 SLSNDLIKLYQVVQYINIQNMLLNYYESLPFYIDTDPIVPNIKESiskLSDEQKRTYMYTYLCGEFAHYKDCMFDKVERI 160


                  ....
gi 489148503  158 IETF 161
Cdd:pfam16718 161 LKEF 164
 
Name Accession Description Interval E-value
IFS pfam16718
Immunity factor for SPN; Immunity factor for SPN (IFS) binds to and inhibits the SPN toxin.
 1-161 2.14e-74

Immunity factor for SPN; Immunity factor for SPN (IFS) binds to and inhibits the SPN toxin.


Pssm-ID: 374750  Cd Length: 164  Bit Score: 219.90  E-value: 2.14e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489148503    1 MYKVPKGLEHYQKMFQKEVTVNDLKKYLIGSDKEYRITKRDSYMGDISDPEVILEYGIYPAFIKGYTQLKANIEEALLEM 80
Cdd:pfam16718   1 MYKNPKGYEHYVKLYLKAMSEGKEAEAFLGTDKKYRITQRDSYMQDITDIEVLLEYCLYPLYVEGDTDIKRRTFEILKEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489148503   81 SNSGQALDIYQAVQTLNAENMLLNYYESLPFYLNRQSILANITKA---LKDAHIREAMAHYKLGEFAHYQDTMLDMVERT 157
Cdd:pfam16718  81 SLSNDLIKLYQVVQYINIQNMLLNYYESLPFYIDTDPIVPNIKESiskLSDEQKRTYMYTYLCGEFAHYKDCMFDKVERI 160


                  ....
gi 489148503  158 IETF 161
Cdd:pfam16718 161 LKEF 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH