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Conserved domains on  [gi|489156095|ref|WP_003065775|]
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MULTISPECIES: amino acid ABC transporter permease [Streptococcus]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 15-225 6.49e-79

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 236.12  E-value: 6.49e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  15 RWADFFANFGEFAKGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTn 94
Cdd:COG0765    4 DFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLG- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  95 gvIMISTFFTAVLCVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNT 174
Cdd:COG0765   83 --IDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489156095 175 STVAIISGADIMFTAKAWAYETTNYVPAFAGAALLYFIMCFPLATWARRKE 225
Cdd:COG0765  161 SLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLE 211
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 15-225 6.49e-79

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 236.12  E-value: 6.49e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  15 RWADFFANFGEFAKGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTn 94
Cdd:COG0765    4 DFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLG- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  95 gvIMISTFFTAVLCVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNT 174
Cdd:COG0765   83 --IDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489156095 175 STVAIISGADIMFTAKAWAYETTNYVPAFAGAALLYFIMCFPLATWARRKE 225
Cdd:COG0765  161 SLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLE 211
PRK15100 PRK15100
cystine ABC transporter permease;
28-226 1.17e-34

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 123.32  E-value: 1.17e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  28 KGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTngvIMISTFFTAVL 107
Cdd:PRK15100  17 KGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFG---IELDPIPAAMI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095 108 CVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNTSTVAIISGADIMF 187
Cdd:PRK15100  94 GLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFR 173

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 489156095 188 TAKAWAYETTNYVPAFAGAALLYFIMCFPLATWARRKEE 226
Cdd:PRK15100 174 QAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFEN 212
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 28-225 9.96e-31

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 112.63  E-value: 9.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095   28 KGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTngvIMISTFFTAVL 107
Cdd:TIGR03004   9 QGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIG---LSLDPVTTGVM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  108 CVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNTSTVAIISGADIMF 187
Cdd:TIGR03004  86 VLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTF 165

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 489156095  188 TAKAWAYETTNYVPAFAGAALLYFIMCFPLATWARRKE 225
Cdd:TIGR03004 166 AAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLE 203
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 30-215 1.10e-22

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 91.19  E-value: 1.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  30 FLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTNGVIMISTFFTAVLCV 109
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095 110 GIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNTSTVAIISGAD----I 185
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEapgpG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 489156095 186 MFTAKAWAYETTNYVPAFAGAALLYFIMCF 215
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 48-222 3.41e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 62.70  E-value: 3.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095   48 GVIFGAMS-SSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTNGvimiSTFFTAVLCVGIYHGAYIAEVIRSGIE 126
Cdd:pfam00528   1 GIPLGIIAaLRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILG----HGILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  127 AVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNTSTVAII---SGADIMFTAKAWAYETTNYVPAF 203
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswPGLGLLLIEAILGYDYPEIQGPV 156

                         170
                  ....*....|....*....
gi 489156095  204 AGAALLYFIMCFPLATWAR 222
Cdd:pfam00528 157 LAAALILLLLNLLVDILQR 175
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 15-225 6.49e-79

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 236.12  E-value: 6.49e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  15 RWADFFANFGEFAKGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTn 94
Cdd:COG0765    4 DFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLG- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  95 gvIMISTFFTAVLCVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNT 174
Cdd:COG0765   83 --IDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489156095 175 STVAIISGADIMFTAKAWAYETTNYVPAFAGAALLYFIMCFPLATWARRKE 225
Cdd:COG0765  161 SLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLE 211
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 15-215 6.12e-42

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 142.16  E-value: 6.12e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  15 RWADFFANFGEFAKGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLA---I 91
Cdd:COG4160    2 DLDLLFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGqfeW 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  92 MTNGV---IMISTFFTAVLCVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVV 168
Cdd:COG4160   82 VRESWlwpLLRDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEVI 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 489156095 169 NLIKNTSTVAIISGADIMFTAKAWAYETTNYVPAFAGAALLYFIMCF 215
Cdd:COG4160  162 LMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITF 208
PRK15100 PRK15100
cystine ABC transporter permease;
28-226 1.17e-34

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 123.32  E-value: 1.17e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  28 KGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTngvIMISTFFTAVL 107
Cdd:PRK15100  17 KGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFG---IELDPIPAAMI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095 108 CVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNTSTVAIISGADIMF 187
Cdd:PRK15100  94 GLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFR 173

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 489156095 188 TAKAWAYETTNYVPAFAGAALLYFIMCFPLATWARRKEE 226
Cdd:PRK15100 174 QAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFEN 212
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 26-188 1.28e-32

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 121.79  E-value: 1.28e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  26 FAKGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVY------------------- 86
Cdd:COG4597   88 FLVGLLNTLLVAVLGIVLATILGFLVGIARLSSNWLVSKLATVYVEIFRNIPLLLQIFFWYfavlealpsprqslslfdg 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  87 -------------------------------------------------------YGLAI-------------------- 91
Cdd:COG4597  168 vflnnrglylpapvfepgfgwvlaallaaivaafvlrrwarrrqeatgqrfpvwwISLALlvglpllaflllgaplsldy 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  92 -------MTNGVIMISTFFTAVLCVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLT 164
Cdd:COG4597  248 pelkgfnFRGGLTLSPEFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLT 327

                        250       260
                 ....*....|....*....|....
gi 489156095 165 NQVVNLIKNTSTVAIISGADIMFT 188
Cdd:COG4597  328 SQYLNLTKNSSLAVAIGYPDLVSV 351
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 28-225 9.96e-31

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 112.63  E-value: 9.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095   28 KGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTngvIMISTFFTAVL 107
Cdd:TIGR03004   9 QGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIG---LSLDPVTTGVM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  108 CVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNTSTVAIISGADIMF 187
Cdd:TIGR03004  86 VLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTF 165

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 489156095  188 TAKAWAYETTNYVPAFAGAALLYFIMCFPLATWARRKE 225
Cdd:TIGR03004 166 AAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLE 203
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 28-225 1.62e-27

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 104.37  E-value: 1.62e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  28 KGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTNGViMISTFFTAVL 107
Cdd:PRK09494  17 EGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFNDL-RIDPFTAAVV 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095 108 CVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNTSTVAIISGADImf 187
Cdd:PRK09494  96 TIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAEL-- 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 489156095 188 TAKAWAYETTNY--VPAFAGAALLYFIMCFPLATWARRKE 225
Cdd:PRK09494 174 TRQGQEIIAGNFraLEIWSAVAVIYLIITLVLSFILRRLE 213
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
33-212 7.18e-25

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 98.21  E-value: 7.18e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  33 TLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYG----LAIMTNGV------------ 96
Cdd:PRK11123  14 TVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFGssqlLLTLSDGFtlnlgfvqipvq 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  97 -----IMISTFFTAVLCVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLI 171
Cdd:PRK11123  94 mdienFEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVLL 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 489156095 172 KNTSTVAIISGADIMFTAKAWAYETTNYVPAFAGAALLYFI 212
Cdd:PRK11123 174 KDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLV 214
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
16-215 8.29e-23

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 92.20  E-value: 8.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  16 WADFFANFGEFAKGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTNG 95
Cdd:PRK15107   6 WSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  96 VIMIST-----FFTAVLCVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNL 170
Cdd:PRK15107  86 VLGLSPktdirLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVL 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 489156095 171 IKNTSTVAIISGADIMFTAKAWAYETTNYVPAFAGAALLYFIMCF 215
Cdd:PRK15107 166 FQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISL 210
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 30-215 1.10e-22

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 91.19  E-value: 1.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  30 FLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTNGVIMISTFFTAVLCV 109
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095 110 GIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNTSTVAIISGAD----I 185
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEapgpG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 489156095 186 MFTAKAWAYETTNYVPAFAGAALLYFIMCF 215
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 22-123 8.64e-22

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 86.05  E-value: 8.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095   22 NFGEFAKGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTngvIMIST 101
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIG---IRLSP 77

                          90       100
                  ....*....|....*....|..
gi 489156095  102 FFTAVLCVGIYHGAYIAEVIRS 123
Cdd:TIGR01726  78 LTAAVIALTLFYGAYLAEIFRG 99
artM PRK11122
arginine ABC transporter permease ArtM;
19-213 4.08e-21

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 87.71  E-value: 4.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  19 FFANFGEFAKGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYG----LAIMTN 94
Cdd:PRK11122   1 MLEYLPELLKGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGpgqfPWLQEY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  95 GVI---MISTFFTAVLCVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSlIILPQAVRTILPPLTNQVVNLI 171
Cdd:PRK11122  81 PWLwhlLSQPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRALSSYSNEVVLVF 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 489156095 172 KNTSTVAIISGADIMFTAKAwAYETTNYVPAFAGAALLYFIM 213
Cdd:PRK11122 160 KSTSLAYTITLMDVMGYSQL-LYGRTYDVMVFGAAGIIYLVV 200
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
28-186 2.01e-19

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 83.30  E-value: 2.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  28 KGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTNGV--------IMI 99
Cdd:PRK15135  11 QGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQIALNSVtealgvgqIDI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095 100 STFFTAVLCVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNTSTVAI 179
Cdd:PRK15135  91 DPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVSL 170


                 ....*..
gi 489156095 180 ISGADIM 186
Cdd:PRK15135 171 LGLEDVV 177
PRK15069 PRK15069
histidine ABC transporter permease HisM;
16-226 7.48e-17

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 76.63  E-value: 7.48e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  16 WADFFANFGEFAKGFLYTLGMSICALILAFVLGVIFGAMSSSKSRVLKAISRVYVEVFQNTPLLVQFVFVY---YGLAIM 92
Cdd:PRK15069   9 WKALLWTDGYRFTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYtgmYSLEIV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  93 tNGVIMISTFF-----TAVLCVGIYHGAYIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQV 167
Cdd:PRK15069  89 -RGTDLLDAFFrsglnCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEV 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489156095 168 VNLIKNTSTVAIISGADIMFTAKAWAYETTNYVPAFAGAALLYFIMCFPLaTWARRKEE 226
Cdd:PRK15069 168 ILMLHATTLAFTATVPDILKIARDINSATYQPFQAFGIAAVLYLIISFVL-ISLFRRAE 225
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 48-222 3.41e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 62.70  E-value: 3.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095   48 GVIFGAMS-SSKSRVLKAISRVYVEVFQNTPLLVQFVFVYYGLAIMTNGvimiSTFFTAVLCVGIYHGAYIAEVIRSGIE 126
Cdd:pfam00528   1 GIPLGIIAaLRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILG----HGILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  127 AVPKGQTEAALSQGFTYSQTMSLIILPQAVRTILPPLTNQVVNLIKNTSTVAII---SGADIMFTAKAWAYETTNYVPAF 203
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswPGLGLLLIEAILGYDYPEIQGPV 156

                         170
                  ....*....|....*....
gi 489156095  204 AGAALLYFIMCFPLATWAR 222
Cdd:pfam00528 157 LAAALILLLLNLLVDILQR 175
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 1-160 1.48e-07

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 50.46  E-value: 1.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095   1 MFLLTAAASPFALSRWADFFANFGEFAKGFLY---------------TLGMSICALILAFVLGVIFGAMSS---SKSRVL 62
Cdd:COG3639    9 LLVWSLWGLEFDLGRLIDGLPNLADFLSRFFPpdwsylpdllsalleTLAIALLGTLLGAVLALPLAFLAArnlAPNPWV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  63 KAISRVYVEVFQNTPLLVqfvfvyygLAImtngvIMISTF----FTAVLCVGIYHGAYIAEVIRSGIEAVPKGQTEAALS 138
Cdd:COG3639   89 RLLARRLLNVLRAIPELV--------WAL-----IFVAAVglgpFAGVLALAIHTIGFLGKLFAEAIEEIDPGPVEALRA 155

                        170       180
                 ....*....|....*....|..
gi 489156095 139 QGFTYSQTMSLIILPQAVRTIL 160
Cdd:COG3639  156 TGASRLQVIRYGVLPQVLPQFL 177
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 21-160 1.87e-05

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 44.37  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095  21 ANFGEFAKGFLYTLGMSICALILAFVLGVIFGAMSSSkSRVLKAISRVYVEVFQNTPLLVqfvfvYYGLAIMTNGVIMIS 100
Cdd:COG0600   54 LASGELWEHLLASLLRVLLGFALAALLGVPLGLLLGL-SRLLRRLLDPLLVFLRPIPPLA-----LAPLLILWFGIGEAS 127

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156095 101 TFFTAVLCVGIYhgayIAEVIRSGIEAVPKGQTEAALSQGFTYSQTMSLIILPQAVRTIL 160
Cdd:COG0600  128 KIFVIFLGAFFP----ILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIF 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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