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Conserved domains on  [gi|489156097|ref|WP_003065777|]
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MULTISPECIES: amino acid ABC transporter permease [Streptococcus]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 6-213 2.74e-69

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 210.70  E-value: 2.74e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   6 PTNISFILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIF-----LIFQMKST 80
Cdd:COG0765    9 LDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYfglplLGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  81 PAGITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLySVIA 160
Cdd:COG0765   89 VAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLV-SVIG 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489156097 161 IQELFGKSQILMGRYFeanQVFTLYALIAAIYFVINFTISTISRRLAKKWEKA 213
Cdd:COG0765  168 VPELTRAAQQIASRTF---RPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 6-213 2.74e-69

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 210.70  E-value: 2.74e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   6 PTNISFILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIF-----LIFQMKST 80
Cdd:COG0765    9 LDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYfglplLGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  81 PAGITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLySVIA 160
Cdd:COG0765   89 VAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLV-SVIG 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489156097 161 IQELFGKSQILMGRYFeanQVFTLYALIAAIYFVINFTISTISRRLAKKWEKA 213
Cdd:COG0765  168 VPELTRAAQQIASRTF---RPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
PRK15100 PRK15100
cystine ABC transporter permease;
11-206 1.27e-32

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 117.16  E-value: 1.27e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  11 FILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIF-----LIFQMKSTPAGIT 85
Cdd:PRK15100  14 FLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYyglpqFGIELDPIPAAMI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  86 AFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLySVIAIQELF 165
Cdd:PRK15100  94 GLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLA-ATIQVPELF 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 489156097 166 GKSQILMGRYFEanqVFTLYALIAAIYFVINFTISTISRRL 206
Cdd:PRK15100 173 RQAQLITSRTLE---VFTMYLAASLIYWIMATVLSALQNRF 210
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 9-206 3.77e-23

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 92.60  E-value: 3.77e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097    9 ISFILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVP---NLLWIFIIFLIFQMKSTP--AG 83
Cdd:TIGR03004   4 LPLLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSllvQLFWFYFVLPLIGLSLDPvtTG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   84 ITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLySVIAIQE 163
Cdd:TIGR03004  84 VMVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLV-SLISLAD 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 489156097  164 LFGKSQILMGRYFEANQVFtlyALIAAIYFVINFTISTISRRL 206
Cdd:TIGR03004 163 LTFAAQSIRNLTLDTLSIF---AITLLCYFVMALIIMLIMRVL 202
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 16-200 5.64e-15

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 70.00  E-value: 5.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  16 LWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIFLIFQMK--------STPAGITAF 87
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLlgwgilpgLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  88 TVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLYSVIaiqeLFGK 167
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLG----GGEA 156

                        170       180       190
                 ....*....|....*....|....*....|...
gi 489156097 168 SQILMGRYFEANQVFTLYALIAAIYFVINFTIS 200
Cdd:cd06261  157 PGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 30-212 1.33e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 55.38  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   30 STLIGTVLAVMRNGKnpiLRWISSIYIEFVRNVPNLLWIFIIFLIFQMK----STPAGITAFTVFTSAALAEIIRGGLNG 105
Cdd:pfam00528   1 GIPLGIIAALRRGRR---LDRLLRPLIDLLQALPSFVLAILLVVIAILSilghGILPAIILALLGWAGYARLIRRAALRS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  106 VDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLYSVIAIQELfGKSQILMGRYFEANQVFTLY 185
Cdd:pfam00528  78 LPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGL-GLLLIEAILGYDYPEIQGPV 156

                         170       180
                  ....*....|....*....|....*..
gi 489156097  186 ALIAAIYFVINFTISTISRRLAKKWEK 212
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPRVRK 183
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 6-213 2.74e-69

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 210.70  E-value: 2.74e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   6 PTNISFILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIF-----LIFQMKST 80
Cdd:COG0765    9 LDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYfglplLGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  81 PAGITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLySVIA 160
Cdd:COG0765   89 VAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLV-SVIG 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489156097 161 IQELFGKSQILMGRYFeanQVFTLYALIAAIYFVINFTISTISRRLAKKWEKA 213
Cdd:COG0765  168 VPELTRAAQQIASRTF---RPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
ArtQ COG4215
ABC-type arginine transport system, permease component [Amino acid transport and metabolism];
12-210 5.23e-35

ABC-type arginine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443361 [Multi-domain]  Cd Length: 238  Bit Score: 123.70  E-value: 5.23e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  12 ILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIFL-----------------I 74
Cdd:COG4215   18 LLAGALVTLELALLSLLLGLVLGLLGALAKLSGNRPLRWLATGYTTVVRGVPDLLLILLLYFggqillnaladlfgydgF 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  75 FQMKSTPAGITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSL 154
Cdd:COG4215   98 IEINPFVAGVLALGFVFGAYATEVFRGAFLAVPKGQIEAARAYGMSRWQVFRRILLPQMWRYALPGLGNNWLVLLKDTAL 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489156097 155 LySVIAIQELFGKSQILMGRYFEAnqvFTLYALIAAIYFVINfTISTISRRLAKKW 210
Cdd:COG4215  178 V-SVIGLVDLVRQAQEAAGSTREP---FTFYLAAALIYLALT-TVSELVLARLERR 228
PRK15100 PRK15100
cystine ABC transporter permease;
11-206 1.27e-32

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 117.16  E-value: 1.27e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  11 FILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIF-----LIFQMKSTPAGIT 85
Cdd:PRK15100  14 FLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYyglpqFGIELDPIPAAMI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  86 AFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLySVIAIQELF 165
Cdd:PRK15100  94 GLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLA-ATIQVPELF 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 489156097 166 GKSQILMGRYFEanqVFTLYALIAAIYFVINFTISTISRRL 206
Cdd:PRK15100 173 RQAQLITSRTLE---VFTMYLAASLIYWIMATVLSALQNRF 210
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 2-209 2.60e-28

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 105.91  E-value: 2.60e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   2 SVLTPTnISFILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIFLIFQMKSTP 81
Cdd:PRK09494   6 SAIWPA-IPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFND 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  82 -------AGITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSl 154
Cdd:PRK09494  85 lridpftAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTS- 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489156097 155 LYSVIAIQELFGKSQILMGRYFEANQVFTlyaLIAAIYFVINFTISTISRRLAKK 209
Cdd:PRK09494 164 LFIVIGVAELTRQGQEIIAGNFRALEIWS---AVAVIYLIITLVLSFILRRLERR 215
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
6-209 1.23e-25

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 99.13  E-value: 1.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   6 PTNISFILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVP---NLLWIFII---FLIFQMKS 79
Cdd:PRK15107  10 VPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPlvmVLLWFYLIvpgFLQNVLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  80 TP-------AGITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDT 152
Cdd:PRK15107  90 SPktdirliSAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDT 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489156097 153 SLLYsVIAIQELFGKSQILMGRyfEANQV-FTLYAliAAIYFVINFTISTISRRLAKK 209
Cdd:PRK15107 170 SLVY-VLSLADFFRTASTIGER--DGTQVeMILFA--GFVYFVISLSASLLVSYLKKR 222
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 9-206 3.77e-23

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 92.60  E-value: 3.77e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097    9 ISFILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVP---NLLWIFIIFLIFQMKSTP--AG 83
Cdd:TIGR03004   4 LPLLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSllvQLFWFYFVLPLIGLSLDPvtTG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   84 ITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLySVIAIQE 163
Cdd:TIGR03004  84 VMVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLV-SLISLAD 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 489156097  164 LFGKSQILMGRYFEANQVFtlyALIAAIYFVINFTISTISRRL 206
Cdd:TIGR03004 163 LTFAAQSIRNLTLDTLSIF---AITLLCYFVMALIIMLIMRVL 202
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 12-202 3.67e-22

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 92.90  E-value: 3.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  12 ILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIFLIF---------------- 75
Cdd:COG4597   88 FLVGLLNTLLVAVLGIVLATILGFLVGIARLSSNWLVSKLATVYVEIFRNIPLLLQIFFWYFAVlealpsprqslslfdg 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  76 -------------------------------------------QMK--------------------------------ST 80
Cdd:COG4597  168 vflnnrglylpapvfepgfgwvlaallaaivaafvlrrwarrrQEAtgqrfpvwwislallvglpllaflllgaplslDY 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  81 PA--------GIT----------AFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAII 142
Cdd:COG4597  248 PElkgfnfrgGLTlspefvalllALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLT 327

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489156097 143 SQFVTVIKDTSLlysVIAI--QELFG-KSQILMGRYFEANQVFtlyALIAAIYFVINFTISTI 202
Cdd:COG4597  328 SQYLNLTKNSSL---AVAIgyPDLVSvFAGTTLNQTGQAIEII---AITMAVYLTISLLISLL 384
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 12-206 2.42e-21

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 87.60  E-value: 2.42e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   12 ILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIFLIF-----QMKSTPAGITA 86
Cdd:TIGR03003  13 LIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLpdigiRLPALVAGVLG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   87 FTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLySVIAIQELFG 166
Cdd:TIGR03003  93 LGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVL-SAITVLELMN 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 489156097  167 KSQILMGRYFEANQVFTLYALI-AAIYFVINFTISTISRRL 206
Cdd:TIGR03003 172 QAKSIGNSTFRYLEPMTLVGVFfLILSIISVFFLRRLEARL 212
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 8-101 5.14e-20

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 81.04  E-value: 5.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097    8 NISFILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIFLIF-----QMKSTPA 82
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLpligiRLSPLTA 80

                          90
                  ....*....|....*....
gi 489156097   83 GITAFTVFTSAALAEIIRG 101
Cdd:TIGR01726  81 AVIALTLFYGAYLAEIFRG 99
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
17-209 2.02e-17

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 77.80  E-value: 2.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  17 WLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIF---------------LIFQMKSTP 81
Cdd:PRK11123  12 GMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYfgssqllltlsdgftLNLGFVQIP 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  82 A--------------GITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVT 147
Cdd:PRK11123  92 VqmdienfevspflcGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLV 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489156097 148 VIKDTSLLySVIAIQELFGKSQILMGRYFEAnqvFTLYALIAAIYFVINFTISTISRRLAKK 209
Cdd:PRK11123 172 LLKDTALV-SLISVNDLMLQTKSIATRTQEP---FTWYIIAAAIYLVITLISQYILKRIELR 229
artM PRK11122
arginine ABC transporter permease ArtM;
12-209 5.08e-15

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 70.76  E-value: 5.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  12 ILQG----LWLTIYISFIAIVLSTLIGTVLAVmrngKNPILRWISSIYIEFVRNVPNLLWIFIIF-------------LI 74
Cdd:PRK11122   8 LLKGlhtsLTLTVASLLVALVLALIFTIILTL----KTPVLVWLVRGYITLFTGTPLLVQIFLIYygpgqfpwlqeypWL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  75 FQMKSTP--AGITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIfIYIIFPQAFRKMLPAIISQFVTVIKDT 152
Cdd:PRK11122  84 WHLLSQPwlCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQT-LRILLPYAFKRALSSYSNEVVLVFKST 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489156097 153 SLLYSvIAIQELFGKSQILMGRYFEAnqvfTLYALIAAIYFVINFTISTISRRLAKK 209
Cdd:PRK11122 163 SLAYT-ITLMDVMGYSQLLYGRTYDV----MVFGAAGIIYLVVNGLLTLLMRLIERK 214
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 16-200 5.64e-15

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 70.00  E-value: 5.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  16 LWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIFLIFQMK--------STPAGITAF 87
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLlgwgilpgLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  88 TVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLYSVIaiqeLFGK 167
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLG----GGEA 156

                        170       180       190
                 ....*....|....*....|....*....|...
gi 489156097 168 SQILMGRYFEANQVFTLYALIAAIYFVINFTIS 200
Cdd:cd06261  157 PGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 12-144 2.50e-12

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 63.95  E-value: 2.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  12 ILQGLWLTIYISFIAIVLSTLIGTVLAVM--RN-GKNPILRWISSIYIEFVRNVPNLLWIFIIFLIFQMkSTPAGITAFT 88
Cdd:COG3639   49 LLSALLETLAIALLGTLLGAVLALPLAFLaaRNlAPNPWVRLLARRLLNVLRAIPELVWALIFVAAVGL-GPFAGVLALA 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489156097  89 VFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAfrkmLPAIISQ 144
Cdd:COG3639  128 IHTIGFLGKLFAEAIEEIDPGPVEALRATGASRLQVIRYGVLPQV----LPQFLSY 179
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 1-206 4.23e-12

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 63.33  E-value: 4.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097    1 MSVLTPTNISFILQGLWLTIYISFIAIVLSTLIGTVLAVM--RN-GKNPILRWISSIYIEFVRNVPNLLWIfIIFLIFQM 77
Cdd:TIGR01097  45 MFPPDWSYLPRILKALLETLAMAILGTVLAAVLAVPLALLaaRNiTPSPWLYGLARLLLNFLRAIPELVWA-LIFVAAVG 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   78 KSTPAGITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLYS 157
Cdd:TIGR01097 124 LGPFAGVLALAFHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVLPQFLSYTLYRFEINVRAAAVLGL 203

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489156097  158 VIAiqelFGKSQILMG--RYFEANQVFTLYALIAAIYFVINFTISTISRRL 206
Cdd:TIGR01097 204 VGA----GGIGLELDTaiGLFDYDEVSAIILVILVVVVIIDLISARLRRRL 250
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
12-168 6.71e-12

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 62.50  E-value: 6.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  12 ILQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVPNLLWIFIIFLIFQM-------------- 77
Cdd:PRK15135   9 ILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQIalnsvtealgvgqi 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  78 --KSTPAGITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSL- 154
Cdd:PRK15135  89 diDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALv 168

                        170
                 ....*....|....*...
gi 489156097 155 ----LYSVIAIQELFGKS 168
Cdd:PRK15135 169 sllgLEDVVKATQLAGKS 186
PRK15069 PRK15069
histidine ABC transporter permease HisM;
13-210 1.48e-10

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 58.91  E-value: 1.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  13 LQGLWLTIYISFIAIVLSTLIGTVLAVMRNGKNPILRWISSIYIEFVRNVP---NLLWIFI-IFLIFQMKSTP------- 81
Cdd:PRK15069  20 FTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPlyvQLLVFYTgMYSLEIVRGTDlldaffr 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  82 ----AGITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLYS 157
Cdd:PRK15069 100 sglnCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFT 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489156097 158 VIAIQELFGKSQILMGRYfeanQVFTLYALIAAIYFVINFTISTISRRLAKKW 210
Cdd:PRK15069 180 ATVPDILKIARDINSATY----QPFQAFGIAAVLYLIISFVLISLFRRAERRW 228
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 12-206 1.63e-10

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 59.01  E-value: 1.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  12 ILQGLWLTIYISFIAIVLSTLIGTVLAVMrNGKNPILRWISSIYIEFVRNVPNLLWIFIIFLIFQMKSTPA-GITAFTVF 90
Cdd:COG0600   59 LWEHLLASLLRVLLGFALAALLGVPLGLL-LGLSRLLRRLLDPLLVFLRPIPPLALAPLLILWFGIGEASKiFVIFLGAF 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  91 TSAALAeiIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAfrkmLPAIISQFVTVIKdTSLLYSVIAiqELFGKSQ- 169
Cdd:COG0600  138 FPILLN--TAAGVRSVDPELLELARSLGASRWQILRKVVLPAA----LPYIFTGLRIALG-LAWIGLVVA--ELLGASSg 208

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 489156097 170 -----ILMGRYFEANQVFTLYALIAAIYFVINFTISTISRRL 206
Cdd:COG0600  209 lgyliLDARQLLDTDLVFAAILVIGLLGLLLDLLLRLLERRL 250
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 30-212 1.33e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 55.38  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   30 STLIGTVLAVMRNGKnpiLRWISSIYIEFVRNVPNLLWIFIIFLIFQMK----STPAGITAFTVFTSAALAEIIRGGLNG 105
Cdd:pfam00528   1 GIPLGIIAALRRGRR---LDRLLRPLIDLLQALPSFVLAILLVVIAILSilghGILPAIILALLGWAGYARLIRRAALRS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  106 VDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVIKDTSLLYSVIAIQELfGKSQILMGRYFEANQVFTLY 185
Cdd:pfam00528  78 LPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGL-GLLLIEAILGYDYPEIQGPV 156

                         170       180
                  ....*....|....*....|....*..
gi 489156097  186 ALIAAIYFVINFTISTISRRLAKKWEK 212
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPRVRK 183
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 12-143 1.67e-04

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 41.25  E-value: 1.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097  12 ILQGLWLTIYISFIAIVLSTLIGTVLA-VMRNGKNPILRWISS-IYIEFVrnVPNLLW---IFIIFLIFQMKSTPAGIT- 85
Cdd:COG1177   59 LLDALLNSLLIALLSTLLATVLGTPAAlALARYRFRGRRLLLAlLLLPLV--VPGIVLgvaLLLLFSALGLSGGLWGLIl 136

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489156097  86 AFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQafrkMLPAIIS 143
Cdd:COG1177  137 AHVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPL----IAPGILA 190
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
9-149 8.67e-04

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 38.95  E-value: 8.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489156097   9 ISFILQGLWLTIYISFIA----IVLSTLIGTVLAVMRNGK---NPILRWISSIYIEFVRNVPnllwiFIIFLIFQMKST- 80
Cdd:PRK10782   6 MWLLVRGVWETLAMTFVSgffgFVIGLPVGVLLYVTRPGQiiaNAKLYRTLSALVNIFRSIP-----FIILLVWMIPFTr 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489156097  81 ---------PAGITAFTVFTSAALAEIIRGGLNGVDDGQTEAGLAQGMTNLQIFIYIIFPQAFRKMLPAIISQFVTVI 149
Cdd:PRK10782  81 vivgtsiglQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLV 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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