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Conserved domains on  [gi|489178219|ref|WP_003087729|]
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MULTISPECIES: type III secretion system needle filament protein PscF [Bacteria]

Protein Classification

EscF/YscF/HrpA family type III secretion system needle major subunit( domain architecture ID 10559375)

EscF/YscF/HrpA family type III secretion system needle major subunit is a major component of the type III secretion needle structure

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T3SS_needle_F pfam09392
Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF; Type III secretion systems are ...
 16-84 2.51e-19

Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF; Type III secretion systems are essential virulence determinants for many gram-negative bacterial pathogens. MxiH is an extracellular alpha helical needle that is required for translocation of effector proteins into host cells. Once inside, the effector proteins subvert normal cell function to aid infection. The needle protein F, polymerizes to form a shaft.


:

Pssm-ID: 430579  Cd Length: 67  Bit Score: 73.86  E-value: 2.51e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489178219  16 VANALKEQANAANKDVNDAIKALQGtdNADNPALLAELQHKINKWSVIYNINSTVTRALRDLMQGILQK 84
Cdd:pfam09392  1 VTNALSQGAQKAEQAVQDALNALEA--DPSDPALLAKYQFKLQQYSVFINAQSTAVKAIKDILQGIIQK 67
 
Name Accession Description Interval E-value
T3SS_needle_F pfam09392
Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF; Type III secretion systems are ...
 16-84 2.51e-19

Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF; Type III secretion systems are essential virulence determinants for many gram-negative bacterial pathogens. MxiH is an extracellular alpha helical needle that is required for translocation of effector proteins into host cells. Once inside, the effector proteins subvert normal cell function to aid infection. The needle protein F, polymerizes to form a shaft.


Pssm-ID: 430579  Cd Length: 67  Bit Score: 73.86  E-value: 2.51e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489178219  16 VANALKEQANAANKDVNDAIKALQGtdNADNPALLAELQHKINKWSVIYNINSTVTRALRDLMQGILQK 84
Cdd:pfam09392  1 VTNALSQGAQKAEQAVQDALNALEA--DPSDPALLAKYQFKLQQYSVFINAQSTAVKAIKDILQGIIQK 67
III_needle TIGR02105
type III secretion apparatus needle protein; Type III secretion systems translocate proteins, ...
 13-85 3.28e-14

type III secretion apparatus needle protein; Type III secretion systems translocate proteins, usually virulence factors, out across both inner and outer membranes of certain Gram-negative bacteria and further across the plasma membrane and into the cytoplasm of the host cell. This protein, termed YscF in Yersinia, and EscF, PscF, EprI, etc. in other systems, forms the needle of the injection apparatus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 131160  Cd Length: 72  Bit Score: 60.91  E-value: 3.28e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489178219  13 LDTVANALKEQANAANKDVNDAIKALqgtDNADNPALLAELQHKINKWSVIYNINSTVTRALRDLMQGILQKI 85
Cdd:TIGR02105  3 ISAIAQQLKKPADDANQAVNDSLAAL---DLPNDPELMAELQFALNQYSAYYNIESTIVKMIKDLDSGILQKF 72
PRK15344 PRK15344
type III secretion system needle protein SsaG; Provisional
 18-85 8.42e-04

type III secretion system needle protein SsaG; Provisional


Pssm-ID: 185242  Cd Length: 71  Bit Score: 34.55  E-value: 8.42e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489178219 18 NALKEQANAANKDVNDAIKAlqgtDNADNPALLAELQHKINKWSVIYNINSTVTRALRDLMQGILQKI 85
Cdd:PRK15344  8 DMLSHMAHQAGQAINDKMNG----NDLLNPESMIKAQFALQQYSTFINYESSLIKMIKDMLSGIIAKI 71
 
Name Accession Description Interval E-value
T3SS_needle_F pfam09392
Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF; Type III secretion systems are ...
 16-84 2.51e-19

Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF; Type III secretion systems are essential virulence determinants for many gram-negative bacterial pathogens. MxiH is an extracellular alpha helical needle that is required for translocation of effector proteins into host cells. Once inside, the effector proteins subvert normal cell function to aid infection. The needle protein F, polymerizes to form a shaft.


Pssm-ID: 430579  Cd Length: 67  Bit Score: 73.86  E-value: 2.51e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489178219  16 VANALKEQANAANKDVNDAIKALQGtdNADNPALLAELQHKINKWSVIYNINSTVTRALRDLMQGILQK 84
Cdd:pfam09392  1 VTNALSQGAQKAEQAVQDALNALEA--DPSDPALLAKYQFKLQQYSVFINAQSTAVKAIKDILQGIIQK 67
III_needle TIGR02105
type III secretion apparatus needle protein; Type III secretion systems translocate proteins, ...
 13-85 3.28e-14

type III secretion apparatus needle protein; Type III secretion systems translocate proteins, usually virulence factors, out across both inner and outer membranes of certain Gram-negative bacteria and further across the plasma membrane and into the cytoplasm of the host cell. This protein, termed YscF in Yersinia, and EscF, PscF, EprI, etc. in other systems, forms the needle of the injection apparatus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 131160  Cd Length: 72  Bit Score: 60.91  E-value: 3.28e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489178219  13 LDTVANALKEQANAANKDVNDAIKALqgtDNADNPALLAELQHKINKWSVIYNINSTVTRALRDLMQGILQKI 85
Cdd:TIGR02105  3 ISAIAQQLKKPADDANQAVNDSLAAL---DLPNDPELMAELQFALNQYSAYYNIESTIVKMIKDLDSGILQKF 72
PRK15344 PRK15344
type III secretion system needle protein SsaG; Provisional
 18-85 8.42e-04

type III secretion system needle protein SsaG; Provisional


Pssm-ID: 185242  Cd Length: 71  Bit Score: 34.55  E-value: 8.42e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489178219 18 NALKEQANAANKDVNDAIKAlqgtDNADNPALLAELQHKINKWSVIYNINSTVTRALRDLMQGILQKI 85
Cdd:PRK15344  8 DMLSHMAHQAGQAINDKMNG----NDLLNPESMIKAQFALQQYSTFINYESSLIKMIKDMLSGIIAKI 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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