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Conserved domains on  [gi|489178491|ref|WP_003087999|]
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MULTISPECIES: alpha/beta fold hydrolase [Pseudomonas]

Protein Classification

COG4757 family protein( domain architecture ID 10790890)

COG4757 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
3-275 1.19e-127

Predicted alpha/beta hydrolase [General function prediction only];


:

Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 364.59  E-value: 1.19e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491   3 PPQPRLIDNGNGHPLASHWYRPAGEPRGYLLIVPAMGVEQRFYAPFAAWLAERGYLAITFDYLGMGQSRNGSLRGLEVDV 82
Cdd:COG4757    6 SPESVTITAADGYPLAARLFPPAGPPRAVVLINPATGVPQRFYRPFARYLAERGFAVLTYDYRGIGLSRPGSLRGFDAGY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491  83 LGWARHDCSAMLAAALAESGSKPLYWIGHSLGGQILPFVEGRERIERVFSIASGSGYWKENSPRLRNKVWLFWYLVAPLL 162
Cdd:COG4757   86 RDWGELDLPAVLDALRARFPGLPLLLVGHSLGGQLLGLAPNAERVDRLVTVASGSGYWRDYPPRRRLKVLLFWHLLGPLL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491 163 TPLLGYFPGRRLGMVGDLPRGVIEQWRRWCLHPQYALAD-GEAIRRAFSAVRTPIVSLSFTDDEMMSRRSIESLLGFYRE 241
Cdd:COG4757  166 TRLLGYFPGRRLGFGEDLPAGVARQWRRWCRRPRYFFDDdGEDLEAALAAVTAPVLAISFTDDELAPPAAVDRLLAYYPN 245

                        250       260       270
                 ....*....|....*....|....*....|....
gi 489178491 242 APKTAWRIAPEEIGARHIGHFGFFRPQFAESLWA 275
Cdd:COG4757  246 APVTRRRLAPADLGLKRIGHFGFFRRRFAAALWP 279
 
Name Accession Description Interval E-value
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
3-275 1.19e-127

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 364.59  E-value: 1.19e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491   3 PPQPRLIDNGNGHPLASHWYRPAGEPRGYLLIVPAMGVEQRFYAPFAAWLAERGYLAITFDYLGMGQSRNGSLRGLEVDV 82
Cdd:COG4757    6 SPESVTITAADGYPLAARLFPPAGPPRAVVLINPATGVPQRFYRPFARYLAERGFAVLTYDYRGIGLSRPGSLRGFDAGY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491  83 LGWARHDCSAMLAAALAESGSKPLYWIGHSLGGQILPFVEGRERIERVFSIASGSGYWKENSPRLRNKVWLFWYLVAPLL 162
Cdd:COG4757   86 RDWGELDLPAVLDALRARFPGLPLLLVGHSLGGQLLGLAPNAERVDRLVTVASGSGYWRDYPPRRRLKVLLFWHLLGPLL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491 163 TPLLGYFPGRRLGMVGDLPRGVIEQWRRWCLHPQYALAD-GEAIRRAFSAVRTPIVSLSFTDDEMMSRRSIESLLGFYRE 241
Cdd:COG4757  166 TRLLGYFPGRRLGFGEDLPAGVARQWRRWCRRPRYFFDDdGEDLEAALAAVTAPVLAISFTDDELAPPAAVDRLLAYYPN 245

                        250       260       270
                 ....*....|....*....|....*....|....
gi 489178491 242 APKTAWRIAPEEIGARHIGHFGFFRPQFAESLWA 275
Cdd:COG4757  246 APVTRRRLAPADLGLKRIGHFGFFRRRFAAALWP 279
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 26-117 4.55e-10

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 58.77  E-value: 4.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491   26 GEPRGYLLIVPAMGVEQRFYAPFAAWLAERGYLAITFDYLGMGQSrnGSLRGlevDVLGWARH--DCSAMLAAALAESGS 103
Cdd:pfam12146   1 GEPRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRS--DGKRG---HVPSFDDYvdDLDTFVDKIREEHPG 75

                          90
                  ....*....|....
gi 489178491  104 KPLYWIGHSLGGQI 117
Cdd:pfam12146  76 LPLFLLGHSMGGLI 89
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 21-118 3.27e-03

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 38.72  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491  21 WYRPAGEPRGYLLIVPAMGVEQRFYAPFAAWLAERGYLAITFDYLGMGQSrnGSLRGLeVDVLGWARHDCSAMLAAALAE 100
Cdd:PLN02652 128 WAPAAGEMRGILIIIHGLNEHSGRYLHFAKQLTSCGFGVYAMDWIGHGGS--DGLHGY-VPSLDYVVEDTEAFLEKIRSE 204

                         90
                 ....*....|....*...
gi 489178491 101 SGSKPLYWIGHSLGGQIL 118
Cdd:PLN02652 205 NPGVPCFLFGHSTGGAVV 222
 
Name Accession Description Interval E-value
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
3-275 1.19e-127

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 364.59  E-value: 1.19e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491   3 PPQPRLIDNGNGHPLASHWYRPAGEPRGYLLIVPAMGVEQRFYAPFAAWLAERGYLAITFDYLGMGQSRNGSLRGLEVDV 82
Cdd:COG4757    6 SPESVTITAADGYPLAARLFPPAGPPRAVVLINPATGVPQRFYRPFARYLAERGFAVLTYDYRGIGLSRPGSLRGFDAGY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491  83 LGWARHDCSAMLAAALAESGSKPLYWIGHSLGGQILPFVEGRERIERVFSIASGSGYWKENSPRLRNKVWLFWYLVAPLL 162
Cdd:COG4757   86 RDWGELDLPAVLDALRARFPGLPLLLVGHSLGGQLLGLAPNAERVDRLVTVASGSGYWRDYPPRRRLKVLLFWHLLGPLL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491 163 TPLLGYFPGRRLGMVGDLPRGVIEQWRRWCLHPQYALAD-GEAIRRAFSAVRTPIVSLSFTDDEMMSRRSIESLLGFYRE 241
Cdd:COG4757  166 TRLLGYFPGRRLGFGEDLPAGVARQWRRWCRRPRYFFDDdGEDLEAALAAVTAPVLAISFTDDELAPPAAVDRLLAYYPN 245

                        250       260       270
                 ....*....|....*....|....*....|....
gi 489178491 242 APKTAWRIAPEEIGARHIGHFGFFRPQFAESLWA 275
Cdd:COG4757  246 APVTRRRLAPADLGLKRIGHFGFFRRRFAAALWP 279
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
3-135 4.71e-16

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 75.42  E-value: 4.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491   3 PPQPRLIDNGNGHPLASHWYRPAGEPRGYLLIVPAMGVEQRFYAPFAAWLAERGYLAITFDYLGMGQSrnGSLRGLEVDV 82
Cdd:COG2267    2 TRRLVTLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRS--DGPRGHVDSF 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489178491  83 LGWARhDCSAMLAAALAESGsKPLYWIGHSLGGQILPFV--EGRERIERVFSIAS 135
Cdd:COG2267   80 DDYVD-DLRAALDALRARPG-LPVVLLGHSMGGLIALLYaaRYPDRVAGLVLLAP 132
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 9-115 1.48e-11

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 63.01  E-value: 1.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491   9 IDNGNGHPLASHWYRPAGEPRGYLLIV---PAMGV-EQrfYAPFAAWLAERGYLAITFDYLGMGQSrNGSLRGlevdvLG 84
Cdd:COG1073   15 FKSRDGIKLAGDLYLPAGASKKYPAVVvahGNGGVkEQ--RALYAQRLAELGFNVLAFDYRGYGES-EGEPRE-----EG 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489178491  85 W-ARHDCSAMLAAALAESG--SKPLYWIGHSLGG 115
Cdd:COG1073   87 SpERRDARAAVDYLRTLPGvdPERIGLLGISLGG 120
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 26-117 4.55e-10

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 58.77  E-value: 4.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491   26 GEPRGYLLIVPAMGVEQRFYAPFAAWLAERGYLAITFDYLGMGQSrnGSLRGlevDVLGWARH--DCSAMLAAALAESGS 103
Cdd:pfam12146   1 GEPRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRS--DGKRG---HVPSFDDYvdDLDTFVDKIREEHPG 75

                          90
                  ....*....|....
gi 489178491  104 KPLYWIGHSLGGQI 117
Cdd:pfam12146  76 LPLFLLGHSMGGLI 89
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
9-117 5.52e-08

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 52.33  E-value: 5.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491   9 IDNGNGHPLASHWYRPAG-EPRGYLLIV-PAMGVEQRFYAPFAAWLAERGYLAITFDYLGMGQSRNGSLRGLEVDVLGWA 86
Cdd:COG1506    2 FKSADGTTLPGWLYLPADgKKYPVVVYVhGGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAAI 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 489178491  87 RHdcsamlAAALAESGSKPLYWIGHSLGGQI 117
Cdd:COG1506   82 DY------LAARPYVDPDRIGIYGHSYGGYM 106
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 22-135 2.90e-06

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 45.21  E-value: 2.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491  22 YRPAGEPrgyLLIVPAMGVEQRFYAPFAAWLAERGYLAITFDYLGMGQSRNGSLRGLevdvlgwarhdcSAMLAAALAES 101
Cdd:COG1075    1 YAATRYP---VVLVHGLGGSAASWAPLAPRLRAAGYPVYALNYPSTNGSIEDSAEQL------------AAFVDAVLAAT 65

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 489178491 102 GSKPLYWIGHSLGGQI----LPFVEGRERIERVFSIAS 135
Cdd:COG1075   66 GAEKVDLVGHSMGGLVaryyLKRLGGAAKVARVVTLGT 103
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 13-117 1.37e-05

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 45.38  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491  13 NGHPLASHWYRPAGEPrgyLLIVPAMGVEQRFYAPFAAWLAERgYLAITFDYLGMGQSrngSLRGLEVDVLGWARHdcsa 92
Cdd:COG0596   10 DGVRLHYREAGPDGPP---VVLLHGLPGSSYEWRPLIPALAAG-YRVIAPDLRGHGRS---DKPAGGYTLDDLADD---- 78

                         90       100
                 ....*....|....*....|....*
gi 489178491  93 mLAAALAESGSKPLYWIGHSLGGQI 117
Cdd:COG0596   79 -LAALLDALGLERVVLVGHSMGGMV 102
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
9-115 1.49e-04

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 42.26  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491   9 IDNGNGHPLASHWYRPAGE-PRGYLLIVP-AMGVEQRfYAPFAAWLAERGYLAITFDYLGMGQSRNGSLRGLE-VDVLGW 85
Cdd:COG0412    8 IPTPDGVTLPGYLARPAGGgPRPGVVVLHeIFGLNPH-IRDVARRLAAAGYVVLAPDLYGRGGPGDDPDEARAlMGALDP 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489178491  86 AR--HDCSAMLAAALAESG--SKPLYWIGHSLGG 115
Cdd:COG0412   87 ELlaADLRAALDWLKAQPEvdAGRVGVVGFCFGG 120
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
3-118 1.02e-03

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 40.13  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491   3 PPQPRLIDNGNGHPLASHWYRPAGEPRGYLLIVPAM-GVEQRFYA-PFAAWLAERGYLAITFDYLGMGQSRNGSLRglev 80
Cdd:COG0429   35 PYRRERLELPDGDFVDLDWSDPPAPSKPLVVLLHGLeGSSDSHYArGLARALYARGWDVVRLNFRGCGGEPNLLPR---- 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 489178491  81 dvlgwARHDC-----SAMLAAALAESGSKPLYWIGHSLGGQIL 118
Cdd:COG0429  111 -----LYHSGdtedlVWVLAHLRARYPYAPLYAVGFSLGGNLL 148
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 52-117 1.50e-03

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 39.41  E-value: 1.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489178491   52 LAERGYLAITFDYLGMGQSRNGSLRGlevdvlGWARHDCSAMLAAALAESGSKPLYWIGHSLGGQI 117
Cdd:pfam00561  23 LARDGFRVIALDLRGFGKSSRPKAQD------DYRTDDLAEDLEYILEALGLEKVNLVGHSMGGLI 82
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 21-118 3.27e-03

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 38.72  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178491  21 WYRPAGEPRGYLLIVPAMGVEQRFYAPFAAWLAERGYLAITFDYLGMGQSrnGSLRGLeVDVLGWARHDCSAMLAAALAE 100
Cdd:PLN02652 128 WAPAAGEMRGILIIIHGLNEHSGRYLHFAKQLTSCGFGVYAMDWIGHGGS--DGLHGY-VPSLDYVVEDTEAFLEKIRSE 204

                         90
                 ....*....|....*...
gi 489178491 101 SGSKPLYWIGHSLGGQIL 118
Cdd:PLN02652 205 NPGVPCFLFGHSTGGAVV 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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