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Conserved domains on  [gi|489178695|ref|WP_003088200|]
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MULTISPECIES: cupin domain-containing protein [Pseudomonas]

Protein Classification

cupin domain-containing protein( domain architecture ID 10007407)

cupin domain-containing protein, part of a functionally diverse superfamily with the active site generally located at the center of a conserved domain forming a beta-barrel fold

CATH:  2.60.120.10
Gene Ontology:  GO:0046872
PubMed:  19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
9-114 4.52e-34

Predicted enzyme of the cupin superfamily [General function prediction only];


:

Pssm-ID: 442673  Cd Length: 108  Bit Score: 113.54  E-value: 4.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178695   9 DDESPFTSPTPVGQPLGEPVAltRTAAHRPLADGNGVTGIWECTPGRFRRQVEQAEYSYIVSGEGRFTPDEGQAVEFRAG 88
Cdd:COG3450    5 AVEPESDPPAPERILEGDPSA--RTWNLFTSPDGGVSAGVWECTPGKFRWDYDEDEFCYILEGRVTVTDDDGEPVEFGAG 82

                         90       100
                 ....*....|....*....|....*.
gi 489178695  89 DALYFAAATQGTWDIRQTVRKTYLIF 114
Cdd:COG3450   83 DSFVFPAGFKGTWEVLETVRKHYVIR 108
 
Name Accession Description Interval E-value
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
9-114 4.52e-34

Predicted enzyme of the cupin superfamily [General function prediction only];


Pssm-ID: 442673  Cd Length: 108  Bit Score: 113.54  E-value: 4.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178695   9 DDESPFTSPTPVGQPLGEPVAltRTAAHRPLADGNGVTGIWECTPGRFRRQVEQAEYSYIVSGEGRFTPDEGQAVEFRAG 88
Cdd:COG3450    5 AVEPESDPPAPERILEGDPSA--RTWNLFTSPDGGVSAGVWECTPGKFRWDYDEDEFCYILEGRVTVTDDDGEPVEFGAG 82

                         90       100
                 ....*....|....*....|....*.
gi 489178695  89 DALYFAAATQGTWDIRQTVRKTYLIF 114
Cdd:COG3450   83 DSFVFPAGFKGTWEVLETVRKHYVIR 108
cupin_TM1112-like cd02227
Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial ...
 46-113 1.60e-31

Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial and plant proteins homologous to TM1112, a Thermotoga maritima protein of unknown function with a cupin beta barrel domain. TM1112 (also known as DUF861) is a subfamily of RmlC-like cupins with a conserved "jelly roll-like" beta-barrel fold; structures indicate that a monomer is the biologically-relevant form.


Pssm-ID: 380356 [Multi-domain]  Cd Length: 69  Bit Score: 106.13  E-value: 1.60e-31
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489178695  46 TGIWECTPGRFRRQVEQAEYSYIVSGEGRFTPDEGQAVEFRAGDALYFAAATQGTWDIRQTVRKTYLI 113
Cdd:cd02227    2 WGIWECTPGKFPWNYDEDEFCYILEGEVRVTPEDGEPVTFKAGDLVVFPAGFSGTWEVLEPVRKHYVF 69
Cupin_3 pfam05899
EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly ...
 40-111 4.46e-29

EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly roll-like beta-barrel fold capable of homodimerization found in bacteria, plant and fungi. It is present in EutQ family from the eut operon, involved in ethanolamine degradation. EutQ is essential during anoxic growth and has acetate kinase activity. The cupin domain from EutQ does not possess the His residues responsible for metal coordination in other classes of cupins. This domain is also found in (S)-ureidoglycine aminohydrolase (UGlyAH) from E.coli, which is involved in the anaerobic nitrogen utilization via the assimilation of allantoin. It catalyzes the deamination of allantoin to produce S-ureidoglycolate and ammonia from S-ureidoglycine.


Pssm-ID: 399116 [Multi-domain]  Cd Length: 74  Bit Score: 100.06  E-value: 4.46e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489178695   40 ADGNGVTGIWECTPGRFRRQVEQAEYSYIVSGEGRFTPDEGQAVEFRAGDALYFAAATQGTWDIRQTVRKTY 111
Cdd:pfam05899   3 PLGVFSWGIWECTPGKFRWTYEEDETCYILSGEVTVTPEGGKTVTLRAGDLVVLPKGLSGTWDVLETVRKHY 74
 
Name Accession Description Interval E-value
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
9-114 4.52e-34

Predicted enzyme of the cupin superfamily [General function prediction only];


Pssm-ID: 442673  Cd Length: 108  Bit Score: 113.54  E-value: 4.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178695   9 DDESPFTSPTPVGQPLGEPVAltRTAAHRPLADGNGVTGIWECTPGRFRRQVEQAEYSYIVSGEGRFTPDEGQAVEFRAG 88
Cdd:COG3450    5 AVEPESDPPAPERILEGDPSA--RTWNLFTSPDGGVSAGVWECTPGKFRWDYDEDEFCYILEGRVTVTDDDGEPVEFGAG 82

                         90       100
                 ....*....|....*....|....*.
gi 489178695  89 DALYFAAATQGTWDIRQTVRKTYLIF 114
Cdd:COG3450   83 DSFVFPAGFKGTWEVLETVRKHYVIR 108
cupin_TM1112-like cd02227
Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial ...
 46-113 1.60e-31

Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial and plant proteins homologous to TM1112, a Thermotoga maritima protein of unknown function with a cupin beta barrel domain. TM1112 (also known as DUF861) is a subfamily of RmlC-like cupins with a conserved "jelly roll-like" beta-barrel fold; structures indicate that a monomer is the biologically-relevant form.


Pssm-ID: 380356 [Multi-domain]  Cd Length: 69  Bit Score: 106.13  E-value: 1.60e-31
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489178695  46 TGIWECTPGRFRRQVEQAEYSYIVSGEGRFTPDEGQAVEFRAGDALYFAAATQGTWDIRQTVRKTYLI 113
Cdd:cd02227    2 WGIWECTPGKFPWNYDEDEFCYILEGEVRVTPEDGEPVTFKAGDLVVFPAGFSGTWEVLEPVRKHYVF 69
Cupin_3 pfam05899
EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly ...
 40-111 4.46e-29

EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly roll-like beta-barrel fold capable of homodimerization found in bacteria, plant and fungi. It is present in EutQ family from the eut operon, involved in ethanolamine degradation. EutQ is essential during anoxic growth and has acetate kinase activity. The cupin domain from EutQ does not possess the His residues responsible for metal coordination in other classes of cupins. This domain is also found in (S)-ureidoglycine aminohydrolase (UGlyAH) from E.coli, which is involved in the anaerobic nitrogen utilization via the assimilation of allantoin. It catalyzes the deamination of allantoin to produce S-ureidoglycolate and ammonia from S-ureidoglycine.


Pssm-ID: 399116 [Multi-domain]  Cd Length: 74  Bit Score: 100.06  E-value: 4.46e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489178695   40 ADGNGVTGIWECTPGRFRRQVEQAEYSYIVSGEGRFTPDEGQAVEFRAGDALYFAAATQGTWDIRQTVRKTY 111
Cdd:pfam05899   3 PLGVFSWGIWECTPGKFRWTYEEDETCYILSGEVTVTPEGGKTVTLRAGDLVVLPKGLSGTWDVLETVRKHY 74
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
37-97 2.56e-04

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 37.69  E-value: 2.56e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489178695  37 RPLADGNGVTG----IWECTPGR----FRRQVEQAEYSYIVSGEGRFTpDEGQAVEFRAGDALYFAAAT 97
Cdd:COG3837   17 RRLGDALGLTRlgvnLITLPPGAssspYHAHSAEEEFVYVLEGELTLR-IGGEEYVLEPGDSVGFPAGV 84
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 62-93 8.53e-04

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 35.31  E-value: 8.53e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 489178695   62 QAEYSYIVSGEGRFTPDeGQAVEFRAGDALYF 93
Cdd:pfam07883  19 EDEFFYVLEGEGELTVD-GEEVVLKAGDSVYF 49
OxdD COG2140
Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate ...
 52-93 1.21e-03

Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate transport and metabolism]; Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 441743 [Multi-domain]  Cd Length: 115  Bit Score: 35.71  E-value: 1.21e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 489178695  52 TPGRFRR---QVEQAEYSYIVSGEGRFT----PDEGQAVEFRAGDALYF 93
Cdd:COG2140   11 EPGGVREehwHPNAAEWYYVLSGEARMTvqdpPGRARTVDVGPGDVVYV 59
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
35-101 2.68e-03

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 34.73  E-value: 2.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489178695  35 AHRPLADGNGVTGIWECT--PG-RFRRQV--EQAEYSYIVSGEGRFTPDeGQAVEFRAGDALYFAAatqGTW 101
Cdd:COG0662   16 SYEVLGEGGERLSVKRITvpPGaELSLHVhpHRDEFFYVLEGTGEVTIG-DEEVELKAGDSVYIPA---GVP 83
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
64-95 2.73e-03

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 34.44  E-value: 2.73e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 489178695  64 EYSYIVSGEGRFTPDeGQAVEFRAGDALYFAA 95
Cdd:COG1917   45 ELIYVLEGEGEVEVG-GEEYELKPGDVVFIPP 75
cupin_TM1287-like cd02221
Thermotoga maritima TM1287 decarboxylase, cupin domain; This family includes bacterial ...
 64-92 6.55e-03

Thermotoga maritima TM1287 decarboxylase, cupin domain; This family includes bacterial proteins homologous to TM1287 decarboxylase, a Thermotoga maritima manganese-containing cupin thought to catalyze the conversion of oxalate to formate and carbon dioxide, due to its similarity to oxalate decarboxylase (OXDC) from Bacillus subtilis. TM1287 shows a cupin fold with a conserved "jelly roll-like" beta-barrel fold and forms a homodimer.


Pssm-ID: 380350 [Multi-domain]  Cd Length: 93  Bit Score: 33.21  E-value: 6.55e-03
                         10        20
                 ....*....|....*....|....*....
gi 489178695  64 EYSYIVSGEGRFTpDEGQAVEFRAGDALY 92
Cdd:cd02221   42 EIYYILSGEGLYT-DNGKEYEVKAGDVTF 69
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 47-95 8.05e-03

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 32.84  E-value: 8.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489178695  47 GIWECTPGR---FRRQVEQAEYSYIVSGEGRFTPDEGQAVEFRAGDALYFAA 95
Cdd:cd02208    2 SVVTLPPGTsspPHWHPEQDEIFYVLSGEGELTLDDGETVELKAGDIVLIPP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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