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Conserved domains on  [gi|489179022|ref|WP_003088524|]
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MULTISPECIES: quinoprotein ethanol dehydrogenase [Pseudomonas]

Protein Classification

PQQ-dependent methanol/ethanol family dehydrogenase( domain architecture ID 11496382)

PQQ-dependent methanol/ethanol family dehydrogenase such as quinoprotein alcohol dehydrogenase (cytochrome c), which catalyzes the oxidation of primary (and some secondary) alcohols to the corresponding aldehydes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 36-586 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


:

Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 877.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022   36 DVTWEDIANDDKTTGDVLQYGMGTHAQRWSPLKQVNADNVFKLTPAWSYSFGdeKQRGQESQAIVSDGVIYVTASYSRLF 115
Cdd:TIGR03075   5 AVTNEDLLNDAKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLG--KQRGQESQPLVVDGVMYVTTSYSRVY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  116 ALDAKTGKRLWTYNHRLPDDIRP--CCDVVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVWKKKFADHGAGYTMTGAPT 193
Cdd:TIGR03075  83 ALDAKTGKILWKYDPKLPDDIIPvmCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAAPL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  194 IVKDgktgkvLLIHGSSGDEFGVVGRLFARDPDTGEEIWMRPFVEGHMGRLNGKDSTVTGDVKAPSWPDDrnsptgkveS 273
Cdd:TIGR03075 163 VVKG------KVITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGDMGYLKKTGKPVGGDPGAKTWPGD---------A 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  274 WSHGGGAPWQSASFDAETNTIIVGAGNPGPWNTWARtakggnphDYDSLYTSGQVGVDPSSGEVKWFYQHTPNDAWDFSG 353
Cdd:TIGR03075 228 WKTGGGATWGTGSYDPETNLIYFGTGNPAPWNSHLR--------PGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDG 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  354 NNELVLFDYKaKDGKIVKATAHADRNGFFYVVDRSNGKLQNAFPFVDNITWASHIDLKTGRPVEREGQRPPlpepGQKHG 433
Cdd:TIGR03075 300 VNEMILFDLK-KDGKPRKLLAHADRNGFFYVLDRTNGKLLSAEPFVDKVNWATGVDLKTGRPIEVPEARST----DGKKG 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  434 KAVEVSPPFLGGKNWNPMAYSQDTGLFYVPANHWKEDYWTEEVSYTKGSAYLGMGFRIKRMYDDHVGSLRAMDPVSGKVV 513
Cdd:TIGR03075 375 KPVEVCPGFLGGKNWQPMAYSPKTGLFYVPANHVCMDYWPEKVSYKKGAAYLGAGFTIKPPPDDHIGSLIAWDPITGKIV 454

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489179022  514 WEHKEHLPLWAGVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGG 586
Cdd:TIGR03075 455 WEHKEDFPLWGGVLATAGDLVFTGTLEGYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWGG 527
 
Name Accession Description Interval E-value
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 36-586 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 877.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022   36 DVTWEDIANDDKTTGDVLQYGMGTHAQRWSPLKQVNADNVFKLTPAWSYSFGdeKQRGQESQAIVSDGVIYVTASYSRLF 115
Cdd:TIGR03075   5 AVTNEDLLNDAKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLG--KQRGQESQPLVVDGVMYVTTSYSRVY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  116 ALDAKTGKRLWTYNHRLPDDIRP--CCDVVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVWKKKFADHGAGYTMTGAPT 193
Cdd:TIGR03075  83 ALDAKTGKILWKYDPKLPDDIIPvmCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAAPL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  194 IVKDgktgkvLLIHGSSGDEFGVVGRLFARDPDTGEEIWMRPFVEGHMGRLNGKDSTVTGDVKAPSWPDDrnsptgkveS 273
Cdd:TIGR03075 163 VVKG------KVITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGDMGYLKKTGKPVGGDPGAKTWPGD---------A 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  274 WSHGGGAPWQSASFDAETNTIIVGAGNPGPWNTWARtakggnphDYDSLYTSGQVGVDPSSGEVKWFYQHTPNDAWDFSG 353
Cdd:TIGR03075 228 WKTGGGATWGTGSYDPETNLIYFGTGNPAPWNSHLR--------PGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDG 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  354 NNELVLFDYKaKDGKIVKATAHADRNGFFYVVDRSNGKLQNAFPFVDNITWASHIDLKTGRPVEREGQRPPlpepGQKHG 433
Cdd:TIGR03075 300 VNEMILFDLK-KDGKPRKLLAHADRNGFFYVLDRTNGKLLSAEPFVDKVNWATGVDLKTGRPIEVPEARST----DGKKG 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  434 KAVEVSPPFLGGKNWNPMAYSQDTGLFYVPANHWKEDYWTEEVSYTKGSAYLGMGFRIKRMYDDHVGSLRAMDPVSGKVV 513
Cdd:TIGR03075 375 KPVEVCPGFLGGKNWQPMAYSPKTGLFYVPANHVCMDYWPEKVSYKKGAAYLGAGFTIKPPPDDHIGSLIAWDPITGKIV 454

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489179022  514 WEHKEHLPLWAGVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGG 586
Cdd:TIGR03075 455 WEHKEDFPLWGGVLATAGDLVFTGTLEGYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWGG 527
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 42-613 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 868.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  42 IANDDKTTGDVLQYGMGTHAQRWSPLKQVNADNVFKLTPAWSYSFGDeKQRGQESQAIVSDGVIYVTASYSRLFALDAKT 121
Cdd:cd10277    1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGG-KQRGQESQPIVNDGVMYVTTSYNRVFAIDAKT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 122 GKRLWTYNHRLPDDIRPCCDVVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVWKKKFADHGAGYTMTGAPTIVKDgktg 201
Cdd:cd10277   80 GKELWKYKHRLPEDIRPCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKG---- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 202 kvLLIHGSSGDEFGVVGRLFARDPDTGEEIWMRPFVEGHMGRLNGKdstvtgdvkapswpddrnspTGKVESWSHGGGAP 281
Cdd:cd10277  156 --KVIVGVSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTD--------------------TWPGDAWKTGGGAT 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 282 WQSASFDAETNTIIVGAGNPGPWNTWartakggnPHDYDSLYTSGQVGVDPSSGEVKWFYQHTPNDAWDFSGNNELVLFD 361
Cdd:cd10277  214 WLTGTYDPETNLLYWGVGNPAPWNGD--------LRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFD 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 362 YKaKDGKIVKATAHADRNGFFYVVDRSNGKLQNAFPFVDNITWAShIDLKTGRPVEREGQRPPlpepgqKHGKAVEVSPP 441
Cdd:cd10277  286 YT-KNGKPVKALVHADRNGFFYVLDRTNGKLIWATPFVKKITWAS-IDLKTGRPIYDEDKVPP------KKGKTVDFCPS 357

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 442 FLGGKNWNPMAYSQDTGLFYVPANHWKEDYWTEEVSYTKGSAYLGMGFRIKRMYDDHVGSLRAMDPVSGKVVWEHKEHLP 521
Cdd:cd10277  358 FLGGKNWPPMAYSPDTGLFYVPANHWCMDLTGEPVSYKKGAAYLGAGFTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLP 437

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 522 LWAGVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGGAVPLWGGDMADLTRP 601
Cdd:cd10277  438 LWGGVLTTAGGLVFTGTPDGYFRAFDAKTGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAKLLKN 517

                        570
                 ....*....|..
gi 489179022 602 VAQGGSFWVFKL 613
Cdd:cd10277  518 VPQGGSLWVFAL 529
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
48-614 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 679.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  48 TTGDVLQYGMGTHAQRWSPLKQVNADNVFKLTPAWSYSFGDEKQRGQESQAIVSDGVIYVTASYSRLFALDAKTGKRLWT 127
Cdd:COG4993    1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPERGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 128 YNHRLPDDIrPCCDVVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVWKKKFADHGAGYTMTGAPTIVKDgktgkvLLIH 207
Cdd:COG4993   81 YDPKLPDDA-ACCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKD------KVIV 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 208 GSSGDEFGVVGRLFARDPDTGEEIWMRPFVEGHmgrlngkdstvtGDVKAPSWPDDrnsptgkvESWSHGGGAPWQSASF 287
Cdd:COG4993  154 GGSGGEFGPRGVVRAYDARTGKLVWRFDTIPDP------------GEPGAETWPPG--------DTWKRGGGNVWGTMSY 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 288 DAETNTIIVGAGNPGP-WNTWARtaKGgnphdyDSLYTSGQVGVDPSSGEVKWFYQHTPNDAWDFSGNNELVLFDYKaKD 366
Cdd:COG4993  214 DPELGLVYLPTGNPAPdWNGGQR--PG------DNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLP-VD 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 367 GKIVKATAHADRNGFFYVVDRSNGKLQNAFPFVDNITWASHIDLKTGRPVEREgqrpplpePGQKhGKAVEVSPPFLGGK 446
Cdd:COG4993  285 GKTRKALVQATKNGFIYVLDRETGEPLVTQPFVKPPNWATEIDMWGATPIQTP--------PSLD-GKTTLICPGALGGK 355

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 447 NWNPMAYSQDTGLFYVPANHWKEDYWTEEVSYTKGSAYLGMGFRIKRMYDDHVGSLRAMDPVSGKVVWEHKEHLPLWAGV 526
Cdd:COG4993  356 NWGPAAYDPETGLLYVPANELCMDYELVPREYQAGAPYLGATLTMYPCPAPPWGTLTAIDLNTGKIVWQVPLGFPNWGGP 435

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 527 LATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGGAVPLWGgdmadltrPVAQGG 606
Cdd:COG4993  436 LATAGGLVFIGTLDGYLRAFDAKTGKELWKFRLPSGGQATPMTYEVDGKQYVAVAAGGGGWLGLGL--------YTPQGD 507


                 ....*...
gi 489179022 607 SFWVFKLP 614
Cdd:COG4993  508 YLIAFALP 515
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 65-232 2.95e-15

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 78.05  E-value: 2.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  65 SPLKQVnaDNVFKLTPAWSYSFGDekqrGQES-----QAIVSDGVIYVTASYSRLFALDAKTGKRLWTYNHRLPDDIRPc 139
Cdd:PRK11138  33 SPLPQV--ENQFTPTTVWSTSVGD----GVGDyysrlHPAVAYNKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWFS- 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 140 cdvVNRGAAIYG------DKVFFGTLDASVVALNKNTGKVVWKKKFadhgAGYTMTgAPTiVKDGktgkVLLIHGSSgde 213
Cdd:PRK11138 106 ---KNKSALLSGgvtvagGKVYIGSEKGQVYALNAEDGEVAWQTKV----AGEALS-RPV-VSDG----LVLVHTSN--- 169

                        170
                 ....*....|....*....
gi 489179022 214 fgvvGRLFARDPDTGEEIW 232
Cdd:PRK11138 170 ----GMLQALNESDGAVKW 184
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 100-339 1.93e-13

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 70.12  E-value: 1.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  100 VSDGVIYVTASYSRLFALDAKTGKRLWTYNhrlpddirpcCDVVNRGA-AIYGDKVFFGTLDASVVALNKNTGKVVWkkK 178
Cdd:pfam13360  31 VDGGRLFVATGGGQLVALDAATGKLLWRQT----------LSGEVLGApLVAGGRVFVVAGDGSLIALDAADGRRLW--S 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  179 FADHGAGYTMTGAPTIVKDGKTgkvLLIHGSSgdefgvvGRLFARDPDTGEEIWMRPFVEGHmgrlNGKDSTVTGDVKAP 258
Cdd:pfam13360  99 YQRSGEPLALRSSGSPAVVGDT---VVAGFSS-------GKLVALDPATGKVRWEAPLAAPR----GTNELERLVDITGT 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  259 swpddrnsPT---GKVESWSHGGGApwqsASFDAETNTIivgagnpgpwnTWARTAKGGNPH--DYDSLY---TSGQV-G 329
Cdd:pfam13360 165 --------PVvagGRVFASAYQGRL----VAFDAATGRR-----------LWTREISGPNGPilDGDLLYvvsDDGELyA 221

                         250
                  ....*....|
gi 489179022  330 VDPSSGEVKW 339
Cdd:pfam13360 222 LDRATGAVVW 231
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 98-129 1.52e-05

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 42.14  E-value: 1.52e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 489179022    98 AIVSDGVIYVTASYSRLFALDAKTGKRLWTYN 129
Cdd:smart00564   2 VVLSDGTVYVGSTDGTLYALDAKTGEILWTYK 33
 
Name Accession Description Interval E-value
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 36-586 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 877.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022   36 DVTWEDIANDDKTTGDVLQYGMGTHAQRWSPLKQVNADNVFKLTPAWSYSFGdeKQRGQESQAIVSDGVIYVTASYSRLF 115
Cdd:TIGR03075   5 AVTNEDLLNDAKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLG--KQRGQESQPLVVDGVMYVTTSYSRVY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  116 ALDAKTGKRLWTYNHRLPDDIRP--CCDVVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVWKKKFADHGAGYTMTGAPT 193
Cdd:TIGR03075  83 ALDAKTGKILWKYDPKLPDDIIPvmCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAAPL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  194 IVKDgktgkvLLIHGSSGDEFGVVGRLFARDPDTGEEIWMRPFVEGHMGRLNGKDSTVTGDVKAPSWPDDrnsptgkveS 273
Cdd:TIGR03075 163 VVKG------KVITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGDMGYLKKTGKPVGGDPGAKTWPGD---------A 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  274 WSHGGGAPWQSASFDAETNTIIVGAGNPGPWNTWARtakggnphDYDSLYTSGQVGVDPSSGEVKWFYQHTPNDAWDFSG 353
Cdd:TIGR03075 228 WKTGGGATWGTGSYDPETNLIYFGTGNPAPWNSHLR--------PGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDG 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  354 NNELVLFDYKaKDGKIVKATAHADRNGFFYVVDRSNGKLQNAFPFVDNITWASHIDLKTGRPVEREGQRPPlpepGQKHG 433
Cdd:TIGR03075 300 VNEMILFDLK-KDGKPRKLLAHADRNGFFYVLDRTNGKLLSAEPFVDKVNWATGVDLKTGRPIEVPEARST----DGKKG 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  434 KAVEVSPPFLGGKNWNPMAYSQDTGLFYVPANHWKEDYWTEEVSYTKGSAYLGMGFRIKRMYDDHVGSLRAMDPVSGKVV 513
Cdd:TIGR03075 375 KPVEVCPGFLGGKNWQPMAYSPKTGLFYVPANHVCMDYWPEKVSYKKGAAYLGAGFTIKPPPDDHIGSLIAWDPITGKIV 454

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489179022  514 WEHKEHLPLWAGVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGG 586
Cdd:TIGR03075 455 WEHKEDFPLWGGVLATAGDLVFTGTLEGYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWGG 527
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 42-613 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 868.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  42 IANDDKTTGDVLQYGMGTHAQRWSPLKQVNADNVFKLTPAWSYSFGDeKQRGQESQAIVSDGVIYVTASYSRLFALDAKT 121
Cdd:cd10277    1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGG-KQRGQESQPIVNDGVMYVTTSYNRVFAIDAKT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 122 GKRLWTYNHRLPDDIRPCCDVVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVWKKKFADHGAGYTMTGAPTIVKDgktg 201
Cdd:cd10277   80 GKELWKYKHRLPEDIRPCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKG---- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 202 kvLLIHGSSGDEFGVVGRLFARDPDTGEEIWMRPFVEGHMGRLNGKdstvtgdvkapswpddrnspTGKVESWSHGGGAP 281
Cdd:cd10277  156 --KVIVGVSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTD--------------------TWPGDAWKTGGGAT 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 282 WQSASFDAETNTIIVGAGNPGPWNTWartakggnPHDYDSLYTSGQVGVDPSSGEVKWFYQHTPNDAWDFSGNNELVLFD 361
Cdd:cd10277  214 WLTGTYDPETNLLYWGVGNPAPWNGD--------LRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFD 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 362 YKaKDGKIVKATAHADRNGFFYVVDRSNGKLQNAFPFVDNITWAShIDLKTGRPVEREGQRPPlpepgqKHGKAVEVSPP 441
Cdd:cd10277  286 YT-KNGKPVKALVHADRNGFFYVLDRTNGKLIWATPFVKKITWAS-IDLKTGRPIYDEDKVPP------KKGKTVDFCPS 357

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 442 FLGGKNWNPMAYSQDTGLFYVPANHWKEDYWTEEVSYTKGSAYLGMGFRIKRMYDDHVGSLRAMDPVSGKVVWEHKEHLP 521
Cdd:cd10277  358 FLGGKNWPPMAYSPDTGLFYVPANHWCMDLTGEPVSYKKGAAYLGAGFTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLP 437

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 522 LWAGVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGGAVPLWGGDMADLTRP 601
Cdd:cd10277  438 LWGGVLTTAGGLVFTGTPDGYFRAFDAKTGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAKLLKN 517

                        570
                 ....*....|..
gi 489179022 602 VAQGGSFWVFKL 613
Cdd:cd10277  518 VPQGGSLWVFAL 529
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
48-614 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 679.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  48 TTGDVLQYGMGTHAQRWSPLKQVNADNVFKLTPAWSYSFGDEKQRGQESQAIVSDGVIYVTASYSRLFALDAKTGKRLWT 127
Cdd:COG4993    1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPERGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 128 YNHRLPDDIrPCCDVVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVWKKKFADHGAGYTMTGAPTIVKDgktgkvLLIH 207
Cdd:COG4993   81 YDPKLPDDA-ACCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKD------KVIV 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 208 GSSGDEFGVVGRLFARDPDTGEEIWMRPFVEGHmgrlngkdstvtGDVKAPSWPDDrnsptgkvESWSHGGGAPWQSASF 287
Cdd:COG4993  154 GGSGGEFGPRGVVRAYDARTGKLVWRFDTIPDP------------GEPGAETWPPG--------DTWKRGGGNVWGTMSY 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 288 DAETNTIIVGAGNPGP-WNTWARtaKGgnphdyDSLYTSGQVGVDPSSGEVKWFYQHTPNDAWDFSGNNELVLFDYKaKD 366
Cdd:COG4993  214 DPELGLVYLPTGNPAPdWNGGQR--PG------DNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLP-VD 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 367 GKIVKATAHADRNGFFYVVDRSNGKLQNAFPFVDNITWASHIDLKTGRPVEREgqrpplpePGQKhGKAVEVSPPFLGGK 446
Cdd:COG4993  285 GKTRKALVQATKNGFIYVLDRETGEPLVTQPFVKPPNWATEIDMWGATPIQTP--------PSLD-GKTTLICPGALGGK 355

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 447 NWNPMAYSQDTGLFYVPANHWKEDYWTEEVSYTKGSAYLGMGFRIKRMYDDHVGSLRAMDPVSGKVVWEHKEHLPLWAGV 526
Cdd:COG4993  356 NWGPAAYDPETGLLYVPANELCMDYELVPREYQAGAPYLGATLTMYPCPAPPWGTLTAIDLNTGKIVWQVPLGFPNWGGP 435

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 527 LATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGGAVPLWGgdmadltrPVAQGG 606
Cdd:COG4993  436 LATAGGLVFIGTLDGYLRAFDAKTGKELWKFRLPSGGQATPMTYEVDGKQYVAVAAGGGGWLGLGL--------YTPQGD 507


                 ....*...
gi 489179022 607 SFWVFKLP 614
Cdd:COG4993  508 YLIAFALP 515
PQQ_DH_like cd00216
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ...
 72-612 0e+00

PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.


Pssm-ID: 199833 [Multi-domain]  Cd Length: 434  Bit Score: 586.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  72 ADNVFKLTPAWSYSFGDEKQRGQESQAIVSDGVIYVTASYSRLFALDAKTGKRLWTYNHRLPDD-IRPCCDVVNRGAAIY 150
Cdd:cd00216    1 ADNVFQLTPAWSFSTGDGGNRGSELTPIVVDGVMYATTSFSRVFALDADDGKEIWSYDPALKDGwFEACCDLVNRGVAVW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 151 GDKVFFGTLDASVVALNKNTGKVVWKKKFADHGAGYTMTGAPTIVKDgktgkvLLIHGSSGDEFGVVGRLFARDPDTGEE 230
Cdd:cd00216   81 GGKVYIGVLDGRVYALNAETGKVAWKVKNADVLGGYTATSAPVVVDG------LVIIGSSGDEFGVRGYLTAYDVATGEE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 231 IWMRPFVEGHMGRLNGKDSTVTgdvkapswpdDRNSPTGKVESWSHGGGAPWQSASFDAETNTIIVGAGNPGPWNTWart 310
Cdd:cd00216  155 KWRFYLVMPDPNLLPGKDSTVT----------DRNTPTGDEHTWTSGGGTGWSSAAYDAELNLIYVGGGNPTPWNWG--- 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 311 akgGNPHDYDSLYTSGQVGVDPSSGEVKWFYQHTPNDAWDFSGNNELVLFDYKAKdGKIVKATAHADRNGFFYVVDRSNG 390
Cdd:cd00216  222 ---GNRTPGDNLYTSSIVAVNADTGEMKWQYQTTPHDAWDYDGDNTPVLADIKVK-GKKVKVLFAPAKNGNFYVLDRRNG 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 391 KLQNAFPFVdnitwashidlktgrpveregqrpplpepgqkhgkavevsppflggknwnPMAYSQDTGLFYVPANhwked 470
Cdd:cd00216  298 ELVSARPLV--------------------------------------------------PDSYDPDRELFYVPAN----- 322

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 471 ywteevsytkgsaylgmgfrikrmyddhvGSLRAMDPVSGKVVWEHKEHLPLWAGVLATAGNLVFTGTGDGYFKAFDAKS 550
Cdd:cd00216  323 -----------------------------GRIMALDPVTGVVVWEKSELHPLLGGPLSTAGNLVFVGTSDGYLKAYNADT 373

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489179022 551 GKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGGAVPLWGGdMADLTRPVAQGGSFWVFK 612
Cdd:cd00216  374 GEKLWQQKVPSGFQAEPVTYEVDGEQYVLIQAGGGGAFPLWGG-MADLTRGTQMGGTVVVYK 434
PQQ_ADH_II cd10279
PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of ...
 50-613 7.58e-167

PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of monomeric and soluble type II alcohol dehydrogenases utilizes pyrroloquinoline quinone (PQQ) as a cofactor and is related to ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199837 [Multi-domain]  Cd Length: 549  Bit Score: 487.54  E-value: 7.58e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  50 GDVLQYGMGTHAQRWSPLKQVNADNVFKLTPAWSYSFGDEkqRGQESQAIVSDGVIYVTASYSRLFALDAKTGKRLWTYN 129
Cdd:cd10279    1 GNWLSYGRDYDEQRFSPLTQINRSNVGQLGLAWYFDLDTN--RGQEATPLVVDGVMYVSGPWSVVYALDARTGKLLWQYD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 130 HRLPDDI--RPCCDVVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVWKKKFADHGAGYTMTGAPTIVKdgktGKVLLih 207
Cdd:cd10279   79 PEVDRESgrKACCDVVNRGVAVWDGKVFVGTLDGRLIALDAKTGKEVWSVDTIDPRKPYTITGAPRVAK----GKVVI-- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 208 GSSGDEFGVVGRLFARDPDTGEEIWmRPFveghmgrlngkdsTVTGDVKAP--SWPDDRNSPTGKVESW--SHGGGAPWQ 283
Cdd:cd10279  153 GNGGAEFGVRGYVSAYDAETGKLVW-RFY-------------TVPGNPAKPfeHASLEAAAATWWTGEWwrTGGGGTVWD 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 284 SASFDAETNTIIVGAGNPGPWNTWARTAKGGnphdyDSLYTSGQVGVDPSSGEVKWFYQHTPNDAWDFSGNNELVLFDYK 363
Cdd:cd10279  219 SITYDPELDLLYIGTGNGSPWNRKVRSPGGG-----DNLFLSSIVALDADTGRYKWHYQTTPGDTWDYTATQPIILADLE 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 364 AkDGKIVKATAHADRNGFFYVVDRSNGKLQNAFPFVDnITWASHIDLKTGRPVEREGQRPPLpepgqkhgKAVEVSPPFL 443
Cdd:cd10279  294 I-DGKPRKVLMHAPKNGFFYVLDRATGKLLSAEPFVP-VNWATGIDLKTGRPIENPEARYTK--------GPKLVFPGPL 363

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 444 GGKNWNPMAYSQDTGLFYVPANHWKEDYWTEEVSYTK--GSAYLGMGF--------RIKRMYDDHVGSLRAMDPVSGKVV 513
Cdd:cd10279  364 GAHNWHPMSYNPDTGLVYIPAQEIPAVYEDDPGDFGYnpLGWNTGITPdatpppaaAKRALRKATRGRLVAWDPVTQKAA 443

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 514 WEHKEHLPLWAGVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGGAVPLWGG 593
Cdd:cd10279  444 WRVEHPGPWNGGVLATAGNLVFQGTADGELAAYDARTGEKLWSFDTGSGIVAAPMTYSVDGEQYVAVLAGWGGAGALSGG 523

                        570       580
                 ....*....|....*....|
gi 489179022 594 DMADLTRPVAQGGSFwVFKL 613
Cdd:cd10279  524 PPGAAGKVQNPGRLL-VFKL 542
PQQ_MDH cd10278
Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the ...
 56-613 4.40e-161

Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the utilization of C1 compounds as a source of energy and carbon by bacteria. It catalyzes the oxidation of methanol to formaldehyde, transfering two electrons per methanol to cytochrome c(L) as the acceptor. Methanol dehydrogenase belongs to a family of dehydrogenases with pyrroloquinoline quinone (PQQ) as cofactor, which also includes dehydrogenases specific to other alcohols and membrane-bound glucose dehydrogenases. This alignment model for the large subunit contains an 8-bladed beta-propeller; the functional enzyme forms a heterotetramer composed of two large and two small subunits.


Pssm-ID: 199836 [Multi-domain]  Cd Length: 553  Bit Score: 472.97  E-value: 4.40e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  56 GMGTHAQRWSPLKQVNADNVFKLTPAWSYSFGdeKQRGQESQAIVSDGVIYVTASY-SRLFALD-AKTGKRLWTYNHRLP 133
Cdd:cd10278    5 GKDYANTRYSPLAQINKDNVKNLKVAWTFSTG--VLRGHEGAPLVVGDTMYVVTPFpNNVYALDlNDPGKILWKYKPKQD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 134 DDIRP--CCDVVNRGAAiYGD-KVFFGTLDASVVALNKNTGKVVWKKKFADHGAGYTMTGAPTIVKDgktgKVLLihGSS 210
Cdd:cd10278   83 PSAVAvaCCDVVNRGLA-YADgKIFFNQLDGHLVALDAKTGKEVWKVKNGDPKVGETLTMAPLVVKD----KVIV--GIS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 211 GDEFGVVGRLFARDPDTGEEIWmRPFVEGhmgrlNGKDSTVTGDVKaPSWPD----DRNSPTGKVESWSHGGGAPWQSAS 286
Cdd:cd10278  156 GGEFGVRGYVTAYDLKTGKLVW-RAYSTG-----PDKDVLIGPDFN-PFNPHdggkDLGLSTWPGDAWKIGGGTNWGWYS 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 287 FDAETNTIIVGAGNPGPWNTWARTAkggnphdyDSLYTSGQVGVDPSSGEVKWFYQHTPNDAWDFSGNNELVLFDYKaKD 366
Cdd:cd10278  229 YDPKLNLVYYGTGNPGPWNPTQRPG--------DNKWSMTIFARDPDTGEAKWAYQMTPHDEWDYDGVNEMILVDQT-VD 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 367 GKIVKATAHADRNGFFYVVDRSNGKLQNAFPFvDNITWASHIDLKTGRPVeregqRPPLPEPGQKHgKAVEVSPPFLGGK 446
Cdd:cd10278  300 GKKRKLLVHFDRNGFVYTLDRTTGELLSAEKF-DPVNNWKGVDLKTGRPV-----KDPEKSTHMDH-NVTDICPSAMGGK 372

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 447 NWNPMAYSQDTGLFYVPANHWKEDYWTEEVSYTKGSAYLGMGFRIKRMYDDHVGSLRAMDPVSGKVVWEHKEHLPLWAGV 526
Cdd:cd10278  373 DQQPSSYSPKTGLFYVPTNHLCMDYEPFEVNYTAGQPYVGATLAMYPGPGGHMGQFKAWDPVTGKTKWEIKERFPVWSGT 452

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 527 LATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGG--AVPLWGGD---------- 594
Cdd:cd10278  453 LATAGGLVFYGTLDGWFKAVDAKTGKLLWKFKLPSGIIGNPITYKHDGKQYVAVLSGVGGwaGVGVAAGLrdptaglgav 532

                        570       580
                 ....*....|....*....|.
gi 489179022 595 --MADLTRPVAQGGSFWVFKL 613
Cdd:cd10278  533 gaFKDLPNYTQMGGTLYVFSL 553
PQQ_mGDH cd10280
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ...
 55-586 2.35e-60

Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199838 [Multi-domain]  Cd Length: 616  Bit Score: 212.05  E-value: 2.35e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  55 YGMGTHAQRWSPLKQVNADNVFKLTPAWSYSFGDEKQRGQ-----ESQAIVSDGVIYVTASYSRLFALDAKTGKRLWTYN 129
Cdd:cd10280    4 YGGDPGGTRYSPLDQITPDNVGKLKVAWTYHTGDLPGPDGnegtfEATPLKVGGTLYLCTPHNRVIALDAATGKELWRFD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 130 hrlPDDIRPCCD--VVNRGAAIYGDK---------VFFGTLDASVVALNKNTGKVVWkkKFADHG-------------AG 185
Cdd:cd10280   84 ---PKAGADAAPghQTCRGVSYWEDGaaaaacarrIFFGTGDARLIALDARTGKPCP--DFGDNGvvdlreglgrvkpGF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 186 YTMTGAPTIVKDgktgkvLLIHGSSGDEFGVV----GRLFARDPDTGEEIWMrpFvegHMGRLNGKDSTVTGDvkapSWP 261
Cdd:cd10280  159 YSSTSPPTVYGD------LVIVGSAVADNQAVdapsGVIRAFDVRTGKLVWA--F---DTIPPPGEAGPDTAG----AWY 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 262 ddrnsPTGKVESWSHgggapwqsASFDAETNTIIVGAGNPGP--WntwartakGGNPHdYDSLYTSGQVGVDPSSGEVKW 339
Cdd:cd10280  224 -----TRGGPNVWAG--------MSADEKLGLVYLPTGSATPdfY--------GGDRP-GDNLFANSLVALDAATGKRRW 281

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 340 FYQHTPNDAWDFSGNNELVLFDYKaKDGKIVKATAHADRNGFFYVVDRSNGK----------LQNA-------------- 395
Cdd:cd10280  282 HFQTVHHDLWDYDLPAQPTLVDVP-RDGKTVPAVAQPTKQGFVFVLDRRTGKplwpveerpvPQGDvpgertsptqpfpt 360

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 396 --FPFVDN-ITWAshiDLKTGRPVER------------EGQRPPLPEPGQkhgkavEVSPPFLGGKNWNPMAYSQDTGLF 460
Cdd:cd10280  361 lpPPFARQgLTED---DMWGATPFDQlacriqfrslryEGLFTPPSLDGT------LIFPGNDGGANWGGAAVDPERGIL 431

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 461 YVPANH---------------------WKEDYWTEEVSYTKGSAYLGMgfRIKRMYDDHV-------GSLRAMDPVSGKV 512
Cdd:cd10280  432 YVNSNRlpfviqlvprapgdpagvaggGEGGGGGGGPSPQAGTPYGVG--RGRFLSPLGLpcqappwGTLTAIDLNTGKI 509

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 513 VWEH-----------KEHLPL------WAGVLATAGNLVFTG-TGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDG 574
Cdd:cd10280  510 LWQVplgtvpdlgpkGIPLPIptgtpnLGGPVVTAGGLVFIAaTQDNYLRAFDKATGKELWEARLPAGGQATPMTYEVDG 589

                        650
                 ....*....|..
gi 489179022 575 EQYLGVTVGYGG 586
Cdd:cd10280  590 KQYVVIAAGGHG 601
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 65-233 2.88e-17

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 83.71  E-value: 2.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  65 SPLKQVnaDNVFKLTPAWSYSFGDEKQRGQESQAI-VSDGVIYVTASYSRLFALDAKTGKRLWTYNHRLPddirpccdvV 143
Cdd:COG1520   21 APLPEF--EPSVKVKQLWSASVGDGVGKGYSRLAPaVAGDRVYAADADGRVAALDAATGKELWRVDLGEP---------L 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 144 NRGAAIYGDKVFFGTLDASVVALNKNTGKVVWKKKFAdhgagyTMTGAPTIVKDGktgkVLLIHgsSGDefgvvGRLFAR 223
Cdd:COG1520   90 SGGVGADGGLVVVGTEDGEVIALDADDGEELWRARLS------SEVLAAPAVAGG----RVVVR--TGD-----GRVYAL 152

                        170
                 ....*....|
gi 489179022 224 DPDTGEEIWM 233
Cdd:COG1520  153 DAATGERLWS 162
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 65-232 2.95e-15

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 78.05  E-value: 2.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  65 SPLKQVnaDNVFKLTPAWSYSFGDekqrGQES-----QAIVSDGVIYVTASYSRLFALDAKTGKRLWTYNHRLPDDIRPc 139
Cdd:PRK11138  33 SPLPQV--ENQFTPTTVWSTSVGD----GVGDyysrlHPAVAYNKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWFS- 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 140 cdvVNRGAAIYG------DKVFFGTLDASVVALNKNTGKVVWKKKFadhgAGYTMTgAPTiVKDGktgkVLLIHGSSgde 213
Cdd:PRK11138 106 ---KNKSALLSGgvtvagGKVYIGSEKGQVYALNAEDGEVAWQTKV----AGEALS-RPV-VSDG----LVLVHTSN--- 169

                        170
                 ....*....|....*....
gi 489179022 214 fgvvGRLFARDPDTGEEIW 232
Cdd:PRK11138 170 ----GMLQALNESDGAVKW 184
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 74-341 9.55e-15

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 76.22  E-value: 9.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  74 NVFKLTPAWSYSFGDEKQRGQESQAIVSDGVIYVTASYSRLFALDAKTGKRLWTYNhrlpddiRPCCDVVNRGAAIYGDK 153
Cdd:cd10276   10 PEFDPEVLWSKSVGNGGMAGIDLTPVVAGDMVYAADANGQVSAFNATTGKIIWETS-------LSGKGFLGGTPAVGNGK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 154 VFFGTLDASVVALNKNTGKVVWKKKFADHGAgytmtGAPTIVKDGKtgkvLLIHGSSgdefgvvGRLFARDPDTGEEIWM 233
Cdd:cd10276   83 IFVGTESGYLYALDAKDGSELWRTEVSDSQL-----LSPPTYADGK----IYVGTGD-------GRLYYCNAETGKVVWN 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 234 RP---------------------FVEGHMGRLNGKDsTVTGDVK---APSWPDDRNSPTGKVESwshgggapwqSASFDA 289
Cdd:cd10276  147 RTstapelslrggaapvgaydvvFVGDGNGTVVALN-TGTGVDIwefSVSEPRGRTELPRMIDS----------SVTYVV 215

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489179022 290 ETNTIIVGAGNPGPW----------NTWARTAKGGNPHDY-DSLYTS---GQV-GVDPSSGEVKWFY 341
Cdd:cd10276  216 VGGYLYSTSYQGYLValdfesgqflWSRKASGGTSTSTDAnGRVYVGdgeGSLyCLDASTGDELWSQ 282
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 65-232 7.61e-14

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 73.43  E-value: 7.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022   65 SPLKQVnaDNVFKLTPAWSYSFGD-EKQRGQESQAIVSDGVIYVTASYSRLFALDAKTGKRLWTynHRLPDDIRpccdvv 143
Cdd:TIGR03300  29 AELPEF--QPTVKVDQVWSASVGDgVGHYYLRLQPAVAGGKVYAADADGTVAALDAETGKRLWR--VDLDERLS------ 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  144 nRGAAIYGDKVFFGTLDASVVALNKNTGKVVWKKKfadhgAGYTMTGAPTIvkDGktGKVLLihgSSGDefgvvGRLFAR 223
Cdd:TIGR03300  99 -GGVGADGGLVFVGTEKGEVIALDAEDGKELWRAK-----LSSEVLSPPLV--AN--GLVVV---RTND-----GRLTAL 160


                  ....*....
gi 489179022  224 DPDTGEEIW 232
Cdd:TIGR03300 161 DAATGERLW 169
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 100-339 1.93e-13

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 70.12  E-value: 1.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  100 VSDGVIYVTASYSRLFALDAKTGKRLWTYNhrlpddirpcCDVVNRGA-AIYGDKVFFGTLDASVVALNKNTGKVVWkkK 178
Cdd:pfam13360  31 VDGGRLFVATGGGQLVALDAATGKLLWRQT----------LSGEVLGApLVAGGRVFVVAGDGSLIALDAADGRRLW--S 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  179 FADHGAGYTMTGAPTIVKDGKTgkvLLIHGSSgdefgvvGRLFARDPDTGEEIWMRPFVEGHmgrlNGKDSTVTGDVKAP 258
Cdd:pfam13360  99 YQRSGEPLALRSSGSPAVVGDT---VVAGFSS-------GKLVALDPATGKVRWEAPLAAPR----GTNELERLVDITGT 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  259 swpddrnsPT---GKVESWSHGGGApwqsASFDAETNTIivgagnpgpwnTWARTAKGGNPH--DYDSLY---TSGQV-G 329
Cdd:pfam13360 165 --------PVvagGRVFASAYQGRL----VAFDAATGRR-----------LWTREISGPNGPilDGDLLYvvsDDGELyA 221

                         250
                  ....*....|
gi 489179022  330 VDPSSGEVKW 339
Cdd:pfam13360 222 LDRATGAVVW 231
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 96-236 3.32e-11

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 65.22  E-value: 3.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  96 SQAIVSDGVIYVTASYSRLFALDAKTGKRLWTYNHRLPddirpccDVVNRGAA---IYGDKVFFGTLDASVVALNKNTGK 172
Cdd:COG1520  131 AAPAVAGGRVVVRTGDGRVYALDAATGERLWSYQRPVP-------ALTLRGTSspvIVGGAVLVGFANGKLVALDLANGQ 203

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489179022 173 VVWKKKFAD-HGAgyT-------MTGAPTIVkdgktgkvllihgssGDEFGVV---GRLFARDPDTGEEIWMRPF 236
Cdd:COG1520  204 PLWEQRVAQpRGR--TelerlvdVDGTPVVD---------------GGVVYAVayqGRLAALDLRSGRVLWSRDL 261
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 500-567 3.87e-11

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 65.22  E-value: 3.87e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489179022 500 GSLRAMDPVSGKVVWEHKEHLPLWAGVlATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPP 567
Cdd:COG1520   67 GRVAALDAATGKELWRVDLGEPLSGGV-GADGGLVVVGTEDGEVIALDADDGEELWRARLSSEVLAAP 133
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 500-567 5.94e-11

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 64.57  E-value: 5.94e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489179022  500 GSLRAMDPVSGKVVWEHKEHLPLWAGVlATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPP 567
Cdd:TIGR03300  75 GTVAALDAETGKRLWRVDLDERLSGGV-GADGGLVFVGTEKGEVIALDAEDGKELWRAKLSSEVLSPP 141
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 96-236 1.74e-09

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 59.95  E-value: 1.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022   96 SQAIVSDGVIYVTASYSRLFALDAKTGKRLWTYNHRLPddirpccDVVNRGAA---IYGDKVFFGTLDASVVALNKNTGK 172
Cdd:TIGR03300 139 SPPLVANGLVVVRTNDGRLTALDAATGERLWTYSRVTP-------PLTLRGSAspvIADGGVLVGFAGGKLVALDLQTGQ 211

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489179022  173 VVWKKKFAdHGAGYT-------MTGAPTIvkdgktgkvllihgsSGDEFGVV---GRLFARDPDTGEEIWMRPF 236
Cdd:TIGR03300 212 PLWEQRVA-LPKGRTelerlvdVDGDPVV---------------DGGQVYAVsyqGRVAALDLRSGRVLWKRDA 269
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 500-567 4.53e-09

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 57.41  E-value: 4.53e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489179022  500 GSLRAMDPVSGKVVWEHKEHLPLWAGVlATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPP 567
Cdd:pfam13360   3 GVVTALDAATGAELWRVDLETGLGGGV-AVDGGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAP 69
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 79-232 6.75e-08

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 53.56  E-value: 6.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022   79 TPAWSYSFGDEKQ--RGQESQAIVSDGVIYVTASySRLFALDAKTGKRLWTYNHRLPDDIRPCCDVVNRGAA--IYGDKV 154
Cdd:pfam13360  94 RRLWSYQRSGEPLalRSSGSPAVVGDTVVAGFSS-GKLVALDPATGKVRWEAPLAAPRGTNELERLVDITGTpvVAGGRV 172

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489179022  155 FFGTLDASVVALNKNTGKVVWKKKFadhgAGYTmtgapTIVKDGKTgkvllIHGSSGDefgvvGRLFARDPDTGEEIW 232
Cdd:pfam13360 173 FASAYQGRLVAFDAATGRRLWTREI----SGPN-----GPILDGDL-----LYVVSDD-----GELYALDRATGAVVW 231
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 532-567 6.85e-08

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 48.73  E-value: 6.85e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 489179022  532 NLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPP 567
Cdd:pfam01011   1 GTVYLGSDDGYLYALDAETGKVLWSFKTGGAVLSSP 36
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 500-579 1.44e-07

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 53.87  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 500 GSLRAMDPVSGKVVWEHKEH-LPLWAGVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEqDGEQYL 578
Cdd:cd10276   48 GQVSAFNATTGKIIWETSLSgKGFLGGTPAVGNGKIFVGTESGYLYALDAKDGSELWRTEVSDSQLLSPPTYA-DGKIYV 126


                 .
gi 489179022 579 G 579
Cdd:cd10276  127 G 127
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 99-176 2.71e-06

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 49.93  E-value: 2.71e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489179022   99 IVSDGVIYVTASYSRLFALDAKTGKRLWTYNHRlpddirpccdvVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVWK 176
Cdd:TIGR03300 238 VVDGGQVYAVSYQGRVAALDLRSGRVLWKRDAS-----------SYQGPAVDDNRLYVTDADGVVVALDRRSGSELWK 304
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 96-191 8.09e-06

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 48.39  E-value: 8.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  96 SQAIVSDGVIYVTASYSRLFALDAKTGKRLWTYNHRLPddirpccDVVNRG----AAIYGdKVFFGTLDASVVALNKNTG 171
Cdd:PRK11138 154 SRPVVSDGLVLVHTSNGMLQALNESDGAVKWTVNLDVP-------SLTLRGesapATAFG-GAIVGGDNGRVSAVLMEQG 225

                         90       100
                 ....*....|....*....|
gi 489179022 172 KVVWKKKFadhgagYTMTGA 191
Cdd:PRK11138 226 QLIWQQRI------SQPTGA 239
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 98-129 1.52e-05

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 42.14  E-value: 1.52e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 489179022    98 AIVSDGVIYVTASYSRLFALDAKTGKRLWTYN 129
Cdd:smart00564   2 VVLSDGTVYVGSTDGTLYALDAKTGEILWTYK 33
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 497-568 1.70e-05

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 47.62  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 497 DHVGSLRAMDPVSGKVVWE----------HKEHLPLWAGVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSP 566
Cdd:PRK11138  76 DRAGLVKALDADTGKEIWSvdlsekdgwfSKNKSALLSGGVTVAGGKVYIGSEKGQVYALNAEDGEVAWQTKVAGEALSR 155


                 ..
gi 489179022 567 PI 568
Cdd:PRK11138 156 PV 157
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 500-621 2.91e-05

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 46.85  E-value: 2.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  500 GSLRAMDPVSGKVVWEHKehlpLWAGVLA---TAGNLVFTGTGDGYFKAFDAKSGKELWKFQTgsgiVSPPITWEQDGeq 576
Cdd:TIGR03300 115 GEVIALDAEDGKELWRAK----LSSEVLSpplVANGLVVVRTNDGRLTALDAATGERLWTYSR----VTPPLTLRGSA-- 184

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 489179022  577 ylGVTVGyGGAVpLWGGDMADLTRPVAQGGsfwvfkLPSWDNRTA 621
Cdd:TIGR03300 185 --SPVIA-DGGV-LVGFAGGKLVALDLQTG------QPLWEQRVA 219
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 96-176 4.57e-05

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 45.96  E-value: 4.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  96 SQAIVSDGVIYVTASYSRLFALDAKTGKRLWTYNHRlpddirpccdvVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVW 175
Cdd:COG1520  227 GTPVVDGGVVYAVAYQGRLAALDLRSGRVLWSRDLS-----------SYTGLAVDGNNLYVTDDDGRVWALDRRNGAELW 295


                 .
gi 489179022 176 K 176
Cdd:COG1520  296 K 296
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 92-232 6.27e-05

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 45.57  E-value: 6.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  92 RGQESQAIVSDGVIYVTASySRLFALDAKTGKRLWTYN----------HRLPD-DIRPccdvvnrgaAIYGDKVFFGTLD 160
Cdd:COG1520  173 RGTSSPVIVGGAVLVGFAN-GKLVALDLANGQPLWEQRvaqprgrtelERLVDvDGTP---------VVDGGVVYAVAYQ 242

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489179022 161 ASVVALNKNTGKVVWKKKFadhgAGYTmtgapTIVKDGKTgkvllIHGSSGDefgvvGRLFARDPDTGEEIW 232
Cdd:COG1520  243 GRLAALDLRSGRVLWSRDL----SSYT-----GLAVDGNN-----LYVTDDD-----GRVWALDRRNGAELW 295
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 529-557 2.20e-04

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 38.67  E-value: 2.20e-04
                           10        20
                   ....*....|....*....|....*....
gi 489179022   529 TAGNLVFTGTGDGYFKAFDAKSGKELWKF 557
Cdd:smart00564   4 LSDGTVYVGSTDGTLYALDAKTGEILWTY 32
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 500-555 3.70e-04

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 43.26  E-value: 3.70e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 500 GSLRAMDPVSGKVVWEHKEHLP---LW-AGVLATAGNLVFTGTGDGYFKAFDAKSGKELW 555
Cdd:COG1520  147 GRVYALDAATGERLWSYQRPVPaltLRgTSSPVIVGGAVLVGFANGKLVALDLANGQPLW 206
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 99-176 4.56e-04

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 42.00  E-value: 4.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022   99 IVSDGVIYVTASYSRLFALDAKTGKRLWT-----YNHRLPDdirpccdvvnrgaaiyGDKVFFGTLDASVVALNKNTGKV 173
Cdd:pfam13360 166 VVAGGRVFASAYQGRLVAFDAATGRRLWTreisgPNGPILD----------------GDLLYVVSDDGELYALDRATGAV 229


                  ...
gi 489179022  174 VWK 176
Cdd:pfam13360 230 VWK 232
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 500-555 7.72e-04

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 41.62  E-value: 7.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  500 GSLRAMDPVSGKVVWEHKEHLPLWA----GVLATAGNLVFTGTGDGYFKAFDAKSGKELW 555
Cdd:pfam13360  83 GSLIALDAADGRRLWSYQRSGEPLAlrssGSPAVVGDTVVAGFSSGKLVALDPATGKVRW 142
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 508-588 9.42e-04

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 41.72  E-value: 9.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 508 VSGKVVWEH-------KEHLPLwagVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSppitweqdgeqylGV 580
Cdd:COG1520   30 VKVKQLWSAsvgdgvgKGYSRL---APAVAGDRVYAADADGRVAALDAATGKELWRVDLGEPLSG-------------GV 93


                 ....*...
gi 489179022 581 TVGYGGAV 588
Cdd:COG1520   94 GADGGLVV 101
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 499-562 1.89e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 40.46  E-value: 1.89e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489179022  499 VGSLRAMDPVSGKVVWEhkehLPLWAGVLAT---AGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSG 562
Cdd:pfam13360  42 GGQLVALDAATGKLLWR----QTLSGEVLGAplvAGGRVFVVAGDGSLIALDAADGRRLWSYQRSGE 104
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 528-585 2.57e-03

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 40.69  E-value: 2.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 489179022  528 ATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSppitweqdgeqylGVTVGYG 585
Cdd:TIGR03300  62 AVAGGKVYAADADGTVAALDAETGKRLWRVDLDERLSG-------------GVGADGG 106
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 96-199 3.66e-03

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 40.01  E-value: 3.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022  96 SQAIVSDGVIYVTASYSRLFALDAKTGKRLWTYnhrlpddirpccDVVNRG----AAIY-GDKVFFGTLDASVV-ALNKN 169
Cdd:cd10276  250 STSTDANGRVYVGDGEGSLYCLDASTGDELWSQ------------TVLLGRvlssPAIYvGVYIYVTDNAEGYLyCLKDN 317

                         90       100       110
                 ....*....|....*....|....*....|
gi 489179022 170 TGKVVWKKKFADHgaGYTMTGAptIVKDGK 199
Cdd:cd10276  318 DGLTVARVEVDYS--QYILQGP--AVSDGW 343
Luminal_IRE1 cd09769
The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, ...
 101-236 4.51e-03

The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1; The Luminal domain is a dimerization domain present in Inositol-requiring protein 1 (IRE1), a serine/threonine protein kinase (STK) and a type I transmembrane protein that is localized in the endoplasmic reticulum (ER). IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), is a kinase receptor that also contains an endoribonuclease domain in the cytoplasmic side. It plays roles in the signaling of the unfolded protein response (UPR), which is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. IRE1 acts as an ER stress sensor and is the oldest and most conserved component of the UPR in eukaryotes. During ER stress, IRE1 dimerizes through its luminal domain and forms oligomers, allowing the kinase domain to undergo trans-autophosphorylation. This leads to a conformational change that stimulates its endoribonuclease activity and results in the cleavage of its mRNA substrate, HAC1 in yeast and Xbp1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. Mammals contain two IRE1 proteins, IRE1alpha (or ERN1) and IRE1beta (or ERN2). IRE1alpha is expressed in all cells and tissues while IRE1beta is found only in intestinal epithelial cells.


Pssm-ID: 188875 [Multi-domain]  Cd Length: 295  Bit Score: 39.61  E-value: 4.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 101 SDGVIYVTASYSRLFALDAKTGKRL----WTYNHRLPDDIRPCCDVVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVWK 176
Cdd:cd09769   87 SDGILYTGSKQTTWYTVDPRTGEKIqvlgSGGADSNCPESCVDPDDDEQSECSSSSTIYIGRTEYTVTIYDSKTREPIWN 166

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 177 KKFADHGAgyTMTGAPTIVKDGKTGKVLLIhGSSGDefgvvGRLFARDPDTGEEIWMRPF 236
Cdd:cd09769  167 VTYSDYTP--NSNDRDLQSQYSKTYDLRYI-ASSSD-----GSLVTFDRDTGRVLWVQNL 218
Luminal_IRE1_like cd09213
The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The ...
 101-279 5.28e-03

The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The Luminal domain is a dimerization domain present in Inositol-requiring protein 1 (IRE1), eukaryotic translation Initiation Factor 2-Alpha Kinase 3 (EIF2AK3), and similar proteins. IRE1 and EIF2AK3 are serine/threonine protein kinases (STKs) and are type I transmembrane proteins that are localized in the endoplasmic reticulum (ER). They are kinase receptors that are activated through the release of BiP, a chaperone bound to their luminal domains under unstressed conditions. This results in dimerization through their luminal domains, allowing trans-autophosphorylation of their kinase domains and activation. They play roles in the signaling of the unfolded protein response (UPR), which is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), contains an endoribonuclease domain in its cytoplasmic side and acts as an ER stress sensor. It is the oldest and most conserved component of the UPR in eukaryotes. Its activation results in the cleavage of its mRNA substrate, HAC1 in yeast and Xbp1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. EIF2AK3, also called PKR-like Endoplasmic Reticulum Kinase (PERK), phosphorylates the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. It functions as the central regulator of translational control during the UPR pathway. In addition to the eIF-2 alpha subunit, EIF2AK3 also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR.


Pssm-ID: 188873 [Multi-domain]  Cd Length: 312  Bit Score: 39.40  E-value: 5.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 101 SDGVIYVTASYSRLFALDAKTGK--------RLWTYNHRLPDDIRPCCDVVNrgaAIYGDKVFFGTLDASVVALNKNTGK 172
Cdd:cd09213   92 EDDVVVVGSKRTSVFALDAKTGKiiktyradGLPSTGGSDSDGNSTPGPDEL---QEEEELLYIGRTDYVLQAIDPRSGK 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489179022 173 VVWKKKFADHGAGYTMTGAPTIVKdgKTGKVLLIHGSSGDEFGVVGRLfaRDPDTGEEIWMRPF----VEGHMGRlnGKD 248
Cdd:cd09213  169 ELWNVTYGEYEALTLDADELGTSS--SSSPLSASFRISENEPVPAVYL--LGLQGGKSLWEHLFdspiVSAFDYS--SKL 242

                        170       180       190
                 ....*....|....*....|....*....|..
gi 489179022 249 STVTGDVKAPSWPDDRNSPTG-KVESWSHGGG 279
Cdd:cd09213  243 TNFEGLIKPIFVFQVHEYASSnSVYIGAHENG 274
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 103-129 5.38e-03

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 34.86  E-value: 5.38e-03
                          10        20
                  ....*....|....*....|....*..
gi 489179022  103 GVIYVTASYSRLFALDAKTGKRLWTYN 129
Cdd:pfam01011   1 GTVYLGSDDGYLYALDAETGKVLWSFK 27
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 500-556 6.12e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 38.54  E-value: 6.12e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 489179022  500 GSLRAMDPVSGKVVWEHKEHLPLwaGVLAtAGNLVFTGTGDGYFKAFDAKSGKELWK 556
Cdd:pfam13360 179 GRLVAFDAATGRRLWTREISGPN--GPIL-DGDLLYVVSDDGELYALDRATGAVVWK 232
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 506-565 7.56e-03

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 38.85  E-value: 7.56e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489179022 506 DPVSGKVVWEHKEHLPLWAGV---LATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVS 565
Cdd:cd10276   10 PEFDPEVLWSKSVGNGGMAGIdltPVVAGDMVYAADANGQVSAFNATTGKIIWETSLSGKGFL 72
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 152-178 9.34e-03

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 34.09  E-value: 9.34e-03
                          10        20
                  ....*....|....*....|....*..
gi 489179022  152 DKVFFGTLDASVVALNKNTGKVVWKKK 178
Cdd:pfam01011   1 GTVYLGSDDGYLYALDAETGKVLWSFK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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