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Conserved domains on  [gi|489180340|ref|WP_003089822|]
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MULTISPECIES: AraC family transcriptional regulator [Pseudomonas]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 13673967)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 17-147 9.42e-27

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


:

Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 100.97  E-value: 9.42e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340   17 HGAVERIEAYFAGHGYDPHRHDTYAIGQTLAGVQSFRYRRSQRHSLPGGCLVLHPDELHDGEAGSQEGFRYRMLYVEPAL 96
Cdd:pfam02311   1 NPGLEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPEL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489180340   97 IQQALGGRPLPFVRGGLS-DDPRLIAASRALLQAM--DTPLEPLEEQDALFELA 147
Cdd:pfam02311  81 LERILADISILAGGPLPLlRDPELAALLRALFRLLeeAGRSDDLLAEALLYQLL 134
GlxA super family cl34854
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 171-271 4.78e-20

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


The actual alignment was detected with superfamily member COG4977:

Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 87.52  E-value: 4.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 171 RARQYIHAHLERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLML-GGQTLAEAALAAGFTDQSHM 249
Cdd:COG4977  214 RAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLEtTDLSIEEIAAACGFGSASHF 293

                         90       100
                 ....*....|....*....|..
gi 489180340 250 TRHFGQSYGLPPARWLRMLGRA 271
Cdd:COG4977  294 RRAFRRRFGVSPSAYRRRFRAR 315
 
Name Accession Description Interval E-value
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 17-147 9.42e-27

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 100.97  E-value: 9.42e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340   17 HGAVERIEAYFAGHGYDPHRHDTYAIGQTLAGVQSFRYRRSQRHSLPGGCLVLHPDELHDGEAGSQEGFRYRMLYVEPAL 96
Cdd:pfam02311   1 NPGLEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPEL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489180340   97 IQQALGGRPLPFVRGGLS-DDPRLIAASRALLQAM--DTPLEPLEEQDALFELA 147
Cdd:pfam02311  81 LERILADISILAGGPLPLlRDPELAALLRALFRLLeeAGRSDDLLAEALLYQLL 134
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 171-271 4.78e-20

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 87.52  E-value: 4.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 171 RARQYIHAHLERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLML-GGQTLAEAALAAGFTDQSHM 249
Cdd:COG4977  214 RAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLEtTDLSIEEIAAACGFGSASHF 293

                         90       100
                 ....*....|....*....|..
gi 489180340 250 TRHFGQSYGLPPARWLRMLGRA 271
Cdd:COG4977  294 RRAFRRRFGVSPSAYRRRFRAR 315
HTH_18 pfam12833
Helix-turn-helix domain;
189-267 8.75e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 75.70  E-value: 8.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340  189 LAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLML--GGQTLAEAALAAGFTDQSHMTRHFGQSYGLPPARWLR 266
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLedTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 489180340  267 M 267
Cdd:pfam12833  81 R 81
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
20-271 1.27e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 80.21  E-value: 1.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340  20 VERIEAYFAGHGYDPHRHDTYAIGQTLAGVQSFRYRRSQRHSLPGGCLVLHPDELHDGEAGSQEGFRYRMLYVEPALIQQ 99
Cdd:COG2207    5 ILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 100 ALGGRPLPFVRGGLSDDPRLIAASRALLQAMDTPLEPLEEQDALFELAHALDAVAGNRARGRRHFDFVAAERARQYIHAH 179
Cdd:COG2207   85 LLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 180 LERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLML-GGQTLAEAALAAGFTDQSHMTRHFGQSYG 258
Cdd:COG2207  165 LLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAeTDLSISEIAYELGFSSQSHFSRAFKKRFG 244

                        250
                 ....*....|...
gi 489180340 259 LPPARWLRMLGRA 271
Cdd:COG2207  245 VTPSEYRKRLRAR 257
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
183-265 5.64e-17

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 73.74  E-value: 5.64e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340   183 PLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLML-GGQTLAEAALAAGFTDQSHMTRHFGQSYGLPP 261
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRdTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 489180340   262 ARWL 265
Cdd:smart00342  81 SEYR 84
ftrA PRK09393
transcriptional activator FtrA; Provisional
 174-270 2.52e-10

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 59.98  E-value: 2.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 174 QYIHAHLERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLM-LGGQTLAEAALAAGFTDQSHMTRH 252
Cdd:PRK09393 225 DWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQIAERAGFGSEESLRHH 304

                         90
                 ....*....|....*...
gi 489180340 253 FGQSYGLPPARWLRMLGR 270
Cdd:PRK09393 305 FRRRAATSPAAYRKRFGR 322
cupin_YbfI-like_N cd07001
AraC/XylS family transcriptional regulators similar to Bacillus subtilis YbfI, N-terminal ...
 35-92 7.54e-04

AraC/XylS family transcriptional regulators similar to Bacillus subtilis YbfI, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators, including YbfI, an uncharacterized Bacillus subtilis. In Pseudomonas putida, this protein is thought to regulate the expression of phenylserine aldolase. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380405 [Multi-domain]  Cd Length: 76  Bit Score: 37.37  E-value: 7.54e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489180340  35 HRHDTYAIGQTLAGVQSFRYRRSQRHSLPGGCLVLHPDELHDGEAGSQEGFRYRMLYV 92
Cdd:cd07001   18 HFHDFYVIGFIESGQRTLFCEGKEYTVEPGDLLLINPRDVHSCIQISGRRLDYERINI 75
 
Name Accession Description Interval E-value
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 17-147 9.42e-27

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 100.97  E-value: 9.42e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340   17 HGAVERIEAYFAGHGYDPHRHDTYAIGQTLAGVQSFRYRRSQRHSLPGGCLVLHPDELHDGEAGSQEGFRYRMLYVEPAL 96
Cdd:pfam02311   1 NPGLEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPEL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489180340   97 IQQALGGRPLPFVRGGLS-DDPRLIAASRALLQAM--DTPLEPLEEQDALFELA 147
Cdd:pfam02311  81 LERILADISILAGGPLPLlRDPELAALLRALFRLLeeAGRSDDLLAEALLYQLL 134
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 171-271 4.78e-20

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 87.52  E-value: 4.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 171 RARQYIHAHLERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLML-GGQTLAEAALAAGFTDQSHM 249
Cdd:COG4977  214 RAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLEtTDLSIEEIAAACGFGSASHF 293

                         90       100
                 ....*....|....*....|..
gi 489180340 250 TRHFGQSYGLPPARWLRMLGRA 271
Cdd:COG4977  294 RRAFRRRFGVSPSAYRRRFRAR 315
HTH_18 pfam12833
Helix-turn-helix domain;
189-267 8.75e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 75.70  E-value: 8.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340  189 LAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLML--GGQTLAEAALAAGFTDQSHMTRHFGQSYGLPPARWLR 266
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLedTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 489180340  267 M 267
Cdd:pfam12833  81 R 81
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
20-271 1.27e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 80.21  E-value: 1.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340  20 VERIEAYFAGHGYDPHRHDTYAIGQTLAGVQSFRYRRSQRHSLPGGCLVLHPDELHDGEAGSQEGFRYRMLYVEPALIQQ 99
Cdd:COG2207    5 ILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 100 ALGGRPLPFVRGGLSDDPRLIAASRALLQAMDTPLEPLEEQDALFELAHALDAVAGNRARGRRHFDFVAAERARQYIHAH 179
Cdd:COG2207   85 LLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 180 LERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLML-GGQTLAEAALAAGFTDQSHMTRHFGQSYG 258
Cdd:COG2207  165 LLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAeTDLSISEIAYELGFSSQSHFSRAFKKRFG 244

                        250
                 ....*....|...
gi 489180340 259 LPPARWLRMLGRA 271
Cdd:COG2207  245 VTPSEYRKRLRAR 257
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
183-265 5.64e-17

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 73.74  E-value: 5.64e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340   183 PLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLML-GGQTLAEAALAAGFTDQSHMTRHFGQSYGLPP 261
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRdTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 489180340   262 ARWL 265
Cdd:smart00342  81 SEYR 84
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 168-264 5.88e-11

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 61.99  E-value: 5.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 168 AAERARQYIHAHLERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLMLGGQTLAEAALAAGFTDQS 247
Cdd:COG2169   85 LVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVTDAAYAAGFGSLS 164

                         90
                 ....*....|....*..
gi 489180340 248 HMTRHFGQSYGLPPARW 264
Cdd:COG2169  165 RFYEAFKKLLGMTPSAY 181
ftrA PRK09393
transcriptional activator FtrA; Provisional
 174-270 2.52e-10

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 59.98  E-value: 2.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 174 QYIHAHLERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLM-LGGQTLAEAALAAGFTDQSHMTRH 252
Cdd:PRK09393 225 DWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQIAERAGFGSEESLRHH 304

                         90
                 ....*....|....*...
gi 489180340 253 FGQSYGLPPARWLRMLGR 270
Cdd:PRK09393 305 FRRRAATSPAAYRKRFGR 322
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
161-264 1.95e-09

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 54.72  E-value: 1.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 161 RRHFDFVAAERARQYIHAHLERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRL-DIARRLMLGGQTLAEAAL 239
Cdd:PRK11511   3 RRNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMtEIAQKLKESNEPILYLAE 82

                         90       100
                 ....*....|....*....|....*
gi 489180340 240 AAGFTDQSHMTRHFGQSYGLPPARW 264
Cdd:PRK11511  83 RYGFESQQTLTRTFKNYFDVPPHKY 107
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 122-268 2.77e-06

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 47.72  E-value: 2.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 122 ASRALLQAMDTPLEPLEEQDALFELAHAL--------DAVAGNRARGRRhfdfvaaeRARQYIHAHLERP-LSLDELAQV 192
Cdd:PRK09685 152 SHRLLQQSMNGPALSETESEALLEALIALlrpalhqrESVQPRRERQFQ--------KVVALIDQSIQEEiLRPEWIAGE 223

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489180340 193 AQRERWSLSRDFrALFGTSPYRYLIQRRLDI---ARRLMLGGQTLAEAALAAGFTDQSHMTRHFGQSYGLPPARWLRML 268
Cdd:PRK09685 224 LGISVRSLYRLF-AEQGLVVAQYIRNRRLDRcadDLRPAADDEKITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYRRKF 301
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
178-264 2.59e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 44.66  E-value: 2.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 178 AHLERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLMLGGQTL-AEAALAAGFTDQSHMTRHFGQS 256
Cdd:PRK13502 187 NSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMiSEISMQCGFEDSNYFSVVFTRE 266


                 ....*...
gi 489180340 257 YGLPPARW 264
Cdd:PRK13502 267 TGMTPSQW 274
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
174-262 4.87e-05

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 41.45  E-value: 4.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 174 QYIHAHLERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLMLGGQ-TLAEAALAAGFTDQSHMTRH 252
Cdd:PRK10219  12 AWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTErPIFDIAMDLGYVSQQTFSRV 91

                         90
                 ....*....|
gi 489180340 253 FGQSYGLPPA 262
Cdd:PRK10219  92 FRRQFDRTPS 101
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
179-266 2.17e-04

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 41.92  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 179 HLERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLD-IARRLMLGGQTLAEAALAAGFTDQSHMTRHFGQSY 257
Cdd:PRK15121  17 HLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSkAAVALRLTSRPILDIALQYRFDSQQTFTRAFKKQF 96


                 ....*....
gi 489180340 258 GLPPARWLR 266
Cdd:PRK15121  97 AQTPALYRR 105
cupin_YbfI-like_N cd07001
AraC/XylS family transcriptional regulators similar to Bacillus subtilis YbfI, N-terminal ...
 35-92 7.54e-04

AraC/XylS family transcriptional regulators similar to Bacillus subtilis YbfI, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators, including YbfI, an uncharacterized Bacillus subtilis. In Pseudomonas putida, this protein is thought to regulate the expression of phenylserine aldolase. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380405 [Multi-domain]  Cd Length: 76  Bit Score: 37.37  E-value: 7.54e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489180340  35 HRHDTYAIGQTLAGVQSFRYRRSQRHSLPGGCLVLHPDELHDGEAGSQEGFRYRMLYV 92
Cdd:cd07001   18 HFHDFYVIGFIESGQRTLFCEGKEYTVEPGDLLLINPRDVHSCIQISGRRLDYERINI 75
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
178-264 7.04e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 37.39  E-value: 7.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489180340 178 AHLERPLSLDELAQVAQRERWSLSRDFRALFGTSPYRYLIQRRLDIARRLMLGGQTL-AEAALAAGFTDQSHMTRHFGQS 256
Cdd:PRK13500 217 ASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLiSDISTECGFEDSNYFSVVFTRE 296


                 ....*...
gi 489180340 257 YGLPPARW 264
Cdd:PRK13500 297 TGMTPSQW 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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