|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
6-594 |
9.54e-164 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 498.34 E-value: 9.54e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 6 QFALLGKRRFLPFFITQLLGAFNDNIFKQSLILAILYHLSVSGDRS--LLVNLCALLFILPFFLFSALGGQFGEKYNKDA 83
Cdd:PRK06814 4 KLYLMKSRRFAPLFWTQFFGAFNDNFLKNALVILILYGLSGALGAYnnALVTLAGAVFILPFFIFSALAGQLADKYDKAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 84 LMRALKLAEVGIMLVGAAGFVFGSLPLMFVALFAMGTHSALFGPVKYSILPQHLHEDELVGGNALVEMGTFLAILAGTIG 163
Cdd:PRK06814 84 LAKILKFAEIGIAALAIYGFHLNSVPLLFAALFLMGIHSALFGPIKYSILPDHLNKDELLGANALVEAGTFIAILLGTII 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 164 AGVLMSHAHYAAAVATAVVLVAACgYLASRGIPRAAAALPGLKLDWNIFAQSWSILRLgLGQRPAVSRSLVGNSWFWFLG 243
Cdd:PRK06814 164 GGLATISGNFVILVALLMGIAVLG-WLASLFIPKTGNAAPDLKIDRNIIRSTITLLKY-AKADKRIWLAILGISWFWLVG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 244 AVYLTQIPTFAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSIGLTVFGILLWWHAGGIPPGEA- 322
Cdd:PRK06814 242 AVVLSQLPLLAKETLGGDENVATLFLAVFSVGVAVGSFLASKLSEGRITLLYVPIGALLMGLFGLDLAFASSSVPAEPAq 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 323 PYDWLAVLRHHETWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFMVAAAL-VSILFLsvAKLS 401
Cdd:PRK06814 322 LKSILVFLSKRHGWRILIDLFGLAAAGGLYIVPLFAALQAWANPAHRARVIAANNVLNAAFMVAGTIiLALLQA--LGFS 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 402 IPQLFLALSLMNVAVNVYIFKIVPEFTMRFLVWLLSHTMYRVRHVNLEAIPDEG-AAVLVCNHVSYVDALLIAGSIRRPV 480
Cdd:PRK06814 400 IPWIILFIALANLIVAILILRLLPTNLLRDIFSILFRAFYRVEVKGLENLQKAGkKAVIAANHVSFLDGPLLAAYLPEEP 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 481 RFVMYYRI----FSLPVLnfvfRTAGAVPI------AARHedegiyerafqrIADYLRDGELVCIFPEGKLTADGEMNEF 550
Cdd:PRK06814 480 TFAIDTDIakawWVKPFL----KLAKALPVdptnpmATRT------------LIKEVQKGEKLVIFPEGRITVTGSLMKI 543
|
570 580 590 600
....*....|....*....|....*....|....*....|....
gi 489182154 551 RAGIERIIEETPVPVIPMALQGLWGSFFSRDPNKgFFRRLWSRV 594
Cdd:PRK06814 544 YDGPGMIADKAGAMVVPVRIDGLQFTHFSRLKNQ-VRRKWFPKV 586
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-423 |
1.61e-51 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 182.04 E-value: 1.61e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 15 FLPFFITQLLGAFNDNIFKQSLILAILYHlsvsGDRSLLVNLCALLFILPFFLFSALGGQFGEKYNKDALMRALKLAEVG 94
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQL----TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 95 IMLVGAAGFVFG--SLPLMFVALFAMGTHSALFGPVKYSILPQHLHEDELVGGNALVEMGTFLAILAGTIGAGVLMSHAH 172
Cdd:cd06173 77 LAAVLALLALLGslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 173 yAAAVATAVVLVAACGYLASRGIPRAAAALPGLKLDWNIfaQSWSILRLGLGQRPAVSRSLVGNSWFWFLGAVYLTQIPT 252
Cdd:cd06173 157 -PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLL--RDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 253 FAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSIGLTVFGILLWWhaggippgeapydwlavlrH 332
Cdd:cd06173 234 LAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL-------------------S 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 333 HETWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFMVAAALVSILFLsvAKLSIPQLFLALSLM 412
Cdd:cd06173 295 PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA--DALGLSAVFLLAGAL 372
|
410
....*....|.
gi 489182154 413 NVAVNVYIFKI 423
Cdd:cd06173 373 LLLAALLLLLL 383
|
|
| PlsC |
COG0204 |
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ... |
429-624 |
8.04e-41 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 439974 [Multi-domain] Cd Length: 215 Bit Score: 147.85 E-value: 8.04e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 429 MRFLVWLLSHTM-YRVRHVNLEAIPDEGAAVLVCNHVSYVDALLIAGSIRRPVRFVMYYRIFSLPVLNFVFRTAGAVPI- 506
Cdd:COG0204 16 VRLWARLLLRLLgVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPVd 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 507 -AARHEDegiyERAFQRIADYLRDGELVCIFPEGKLTADGEMNEFRAGIERIIEETPVPVIPMALQGLWGSFFsrdpnKG 585
Cdd:COG0204 96 rSKRRAA----LRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALP-----KG 166
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 489182154 586 FFRRLwSRVSLVAGESVAPGAVERLD-------LQARVTSLRGEAR 624
Cdd:COG0204 167 FLPRP-GKVTVRIGPPIDPSDLEGEDrrelaerLRAAIEALLAELR 211
|
|
| Acyltransferase |
pfam01553 |
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ... |
442-570 |
6.83e-25 |
|
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.
Pssm-ID: 366704 [Multi-domain] Cd Length: 131 Bit Score: 100.05 E-value: 6.83e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 442 RVRHVNLEAIPDEGAAVLVCNHVSYVDALL---IAGSIRRPVRFVMYYRIFSLPVLNFVFRTAGAVPIaaRHEDEGIYER 518
Cdd:pfam01553 1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLlslALYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFI--DRKNRKDAAG 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 489182154 519 AFQRIADYLRDGELVCIFPEGKLTADGEMNEFRAGIERIIEETPVPVIPMAL 570
Cdd:pfam01553 79 TLEYLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAI 130
|
|
| PlsC |
smart00563 |
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ... |
457-573 |
2.76e-24 |
|
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.
Pssm-ID: 214724 [Multi-domain] Cd Length: 118 Bit Score: 98.20 E-value: 2.76e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 457 AVLVCNHVSYVDALL---IAGSIRRPVRFVMYYRIFSLPVLNFVFRTAGAVPIaaRHEDEGIYERAFQRIADYLRDGELV 533
Cdd:smart00563 1 ALVVANHQSFLDPLVlsaLLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFI--DRSNGRKARAALREAVELLKEGEWL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 489182154 534 CIFPEGKLTADGEMNEFRAGIERIIEETPVPVIPMALQGL 573
Cdd:smart00563 79 LIFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
|
|
| AGP_acyltrn |
TIGR00530 |
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ... |
443-571 |
1.81e-17 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]
Pssm-ID: 129621 [Multi-domain] Cd Length: 130 Bit Score: 78.93 E-value: 1.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 443 VRHVNLEAIPDEGAAVLVCNHVSYVDALLIAGSIRRPVRFVMYYRIFSLPVLNFVFRTAGAVPIaARHEDEGI--YERAF 520
Cdd:TIGR00530 4 VEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFI-DRENIRAIatALKAA 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 489182154 521 QRIadyLRDGELVCIFPEGKLTADGEMNEFRAGIERIIEETPVPVIPMALQ 571
Cdd:TIGR00530 83 IEV---LKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
6-594 |
9.54e-164 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 498.34 E-value: 9.54e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 6 QFALLGKRRFLPFFITQLLGAFNDNIFKQSLILAILYHLSVSGDRS--LLVNLCALLFILPFFLFSALGGQFGEKYNKDA 83
Cdd:PRK06814 4 KLYLMKSRRFAPLFWTQFFGAFNDNFLKNALVILILYGLSGALGAYnnALVTLAGAVFILPFFIFSALAGQLADKYDKAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 84 LMRALKLAEVGIMLVGAAGFVFGSLPLMFVALFAMGTHSALFGPVKYSILPQHLHEDELVGGNALVEMGTFLAILAGTIG 163
Cdd:PRK06814 84 LAKILKFAEIGIAALAIYGFHLNSVPLLFAALFLMGIHSALFGPIKYSILPDHLNKDELLGANALVEAGTFIAILLGTII 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 164 AGVLMSHAHYAAAVATAVVLVAACgYLASRGIPRAAAALPGLKLDWNIFAQSWSILRLgLGQRPAVSRSLVGNSWFWFLG 243
Cdd:PRK06814 164 GGLATISGNFVILVALLMGIAVLG-WLASLFIPKTGNAAPDLKIDRNIIRSTITLLKY-AKADKRIWLAILGISWFWLVG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 244 AVYLTQIPTFAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSIGLTVFGILLWWHAGGIPPGEA- 322
Cdd:PRK06814 242 AVVLSQLPLLAKETLGGDENVATLFLAVFSVGVAVGSFLASKLSEGRITLLYVPIGALLMGLFGLDLAFASSSVPAEPAq 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 323 PYDWLAVLRHHETWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFMVAAAL-VSILFLsvAKLS 401
Cdd:PRK06814 322 LKSILVFLSKRHGWRILIDLFGLAAAGGLYIVPLFAALQAWANPAHRARVIAANNVLNAAFMVAGTIiLALLQA--LGFS 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 402 IPQLFLALSLMNVAVNVYIFKIVPEFTMRFLVWLLSHTMYRVRHVNLEAIPDEG-AAVLVCNHVSYVDALLIAGSIRRPV 480
Cdd:PRK06814 400 IPWIILFIALANLIVAILILRLLPTNLLRDIFSILFRAFYRVEVKGLENLQKAGkKAVIAANHVSFLDGPLLAAYLPEEP 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 481 RFVMYYRI----FSLPVLnfvfRTAGAVPI------AARHedegiyerafqrIADYLRDGELVCIFPEGKLTADGEMNEF 550
Cdd:PRK06814 480 TFAIDTDIakawWVKPFL----KLAKALPVdptnpmATRT------------LIKEVQKGEKLVIFPEGRITVTGSLMKI 543
|
570 580 590 600
....*....|....*....|....*....|....*....|....
gi 489182154 551 RAGIERIIEETPVPVIPMALQGLWGSFFSRDPNKgFFRRLWSRV 594
Cdd:PRK06814 544 YDGPGMIADKAGAMVVPVRIDGLQFTHFSRLKNQ-VRRKWFPKV 586
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
9-593 |
1.21e-142 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 443.21 E-value: 1.21e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 9 LLGKRRFLPFFITQLLGAFNDNIFKqSLILAILYHlSVSGDRSLLVNLCALLFILP-FFLFSALGGQFGEKYNKDALMRA 87
Cdd:PRK08633 5 LLKIIGFLPLLLTQFLNAFNDLGHK-ILIQNTLIK-AYDGSEQVILTAIVNALFLLpFLLLSSPAGFLADKFSKNRVIRI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 88 LKLAEVGIMLVGAAGFVFGSLPLMFVALFAMGTHSALFGPVKYSILPQHLHEDELVGGNALVEMGTFLAILAGTIGAGVL 167
Cdd:PRK08633 83 VKLFEVGLTLLIVLAYYLGWFWLAFAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 168 MSHA---------HYAAAVATAVVLVAACGYLASRGIPR--AAAALPGLKLDWNIFAQSWSILRLGLGQRPaVSRSLVGN 236
Cdd:PRK08633 163 FESVngntpseilGRIAPAGLVLLAVAVLGLIFAYRLPKvpAAAPEVFDKKKYLFPKLLWRNLKLLRSDRV-LWLAIIGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 237 SWFWFLGAVYLTQIPTFAKEWLHGDES-VVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSIGLTVFGILLWWhAG 315
Cdd:PRK08633 242 SYFWFISQLAQANFPAYAKEVLGLDNTfQVQYLLAASAIGIGIGSLLAGRLSGRHIELGLVPLGALGLALSLFLLPT-AP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 316 GIppgeapydwlavlrhhetWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFMVAAALVSILFl 395
Cdd:PRK08633 321 SL------------------ASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKVLAANNFLQNVGMLLFLALTTLF- 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 396 SVAKLSIPQLFLALSLMNVAVNVYIFKIVPEFTMRFLVWLLSHTMYRVRHVNLEAIPDEGAAVLVCNHVSYVDALLIAGS 475
Cdd:PRK08633 382 SGLGLSPAGLFYLIALVTLIGTLYTLLLLPDSLLRFLLLLLMHTRYRLRVEGRENIPAKGGALLLGNHVSWIDWALLQAA 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 476 IRRPVRFVMYYRIFSLPVLNFVFRTAGAVPIAARHEDEGIyerafQRIADYLRDGELVCIFPEGKLTADGEMNEFRAGIE 555
Cdd:PRK08633 462 SPRPIRFVMERSIYEKWYLKWFFKLFGVIPISSGGSKESL-----EFIRKALDDGEVVCIFPEGAITRNGQLNEFKRGFE 536
|
570 580 590
....*....|....*....|....*....|....*...
gi 489182154 556 RIIEETPVPVIPMALQGLWGSFFSRDpnKGFFRRLWSR 593
Cdd:PRK08633 537 LIVKGTDVPIIPFYIRGLWGSIFSRA--SGKFLWRWPT 572
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-423 |
1.61e-51 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 182.04 E-value: 1.61e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 15 FLPFFITQLLGAFNDNIFKQSLILAILYHlsvsGDRSLLVNLCALLFILPFFLFSALGGQFGEKYNKDALMRALKLAEVG 94
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQL----TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 95 IMLVGAAGFVFG--SLPLMFVALFAMGTHSALFGPVKYSILPQHLHEDELVGGNALVEMGTFLAILAGTIGAGVLMSHAH 172
Cdd:cd06173 77 LAAVLALLALLGslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 173 yAAAVATAVVLVAACGYLASRGIPRAAAALPGLKLDWNIfaQSWSILRLGLGQRPAVSRSLVGNSWFWFLGAVYLTQIPT 252
Cdd:cd06173 157 -PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLL--RDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 253 FAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSIGLTVFGILLWWhaggippgeapydwlavlrH 332
Cdd:cd06173 234 LAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL-------------------S 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 333 HETWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFMVAAALVSILFLsvAKLSIPQLFLALSLM 412
Cdd:cd06173 295 PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA--DALGLSAVFLLAGAL 372
|
410
....*....|.
gi 489182154 413 NVAVNVYIFKI 423
Cdd:cd06173 373 LLLAALLLLLL 383
|
|
| LPLAT_AGPAT-like |
cd07989 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ... |
429-615 |
6.80e-41 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.
Pssm-ID: 153251 [Multi-domain] Cd Length: 184 Bit Score: 147.03 E-value: 6.80e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 429 MRFLVWLLshtMYRVRHVNLEAIPDEGAAVLVCNHVSYVDALLIAGSIRRPVRFVMYYRIFSLPVLNFVFRTAGAVPIAa 508
Cdd:cd07989 1 LRLLLRLL---GVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPID- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 509 RhEDEGIYERAFQRIADYLRDGELVCIFPEGKLTADGEMNEFRAGIERIIEETPVPVIPMALQGLWGSFFsrdpnKGFFR 588
Cdd:cd07989 77 R-GNGRSAREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLP-----KGKKL 150
|
170 180
....*....|....*....|....*..
gi 489182154 589 RLWSRVSLVAGESVAPGAVERLDLQAR 615
Cdd:cd07989 151 PRPGRVTVRIGEPIPPEGLELAEEDRK 177
|
|
| PlsC |
COG0204 |
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ... |
429-624 |
8.04e-41 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 439974 [Multi-domain] Cd Length: 215 Bit Score: 147.85 E-value: 8.04e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 429 MRFLVWLLSHTM-YRVRHVNLEAIPDEGAAVLVCNHVSYVDALLIAGSIRRPVRFVMYYRIFSLPVLNFVFRTAGAVPI- 506
Cdd:COG0204 16 VRLWARLLLRLLgVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPVd 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 507 -AARHEDegiyERAFQRIADYLRDGELVCIFPEGKLTADGEMNEFRAGIERIIEETPVPVIPMALQGLWGSFFsrdpnKG 585
Cdd:COG0204 96 rSKRRAA----LRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALP-----KG 166
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 489182154 586 FFRRLwSRVSLVAGESVAPGAVERLD-------LQARVTSLRGEAR 624
Cdd:COG0204 167 FLPRP-GKVTVRIGPPIDPSDLEGEDrrelaerLRAAIEALLAELR 211
|
|
| Acyltransferase |
pfam01553 |
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ... |
442-570 |
6.83e-25 |
|
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.
Pssm-ID: 366704 [Multi-domain] Cd Length: 131 Bit Score: 100.05 E-value: 6.83e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 442 RVRHVNLEAIPDEGAAVLVCNHVSYVDALL---IAGSIRRPVRFVMYYRIFSLPVLNFVFRTAGAVPIaaRHEDEGIYER 518
Cdd:pfam01553 1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLlslALYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFI--DRKNRKDAAG 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 489182154 519 AFQRIADYLRDGELVCIFPEGKLTADGEMNEFRAGIERIIEETPVPVIPMAL 570
Cdd:pfam01553 79 TLEYLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAI 130
|
|
| PlsC |
smart00563 |
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ... |
457-573 |
2.76e-24 |
|
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.
Pssm-ID: 214724 [Multi-domain] Cd Length: 118 Bit Score: 98.20 E-value: 2.76e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 457 AVLVCNHVSYVDALL---IAGSIRRPVRFVMYYRIFSLPVLNFVFRTAGAVPIaaRHEDEGIYERAFQRIADYLRDGELV 533
Cdd:smart00563 1 ALVVANHQSFLDPLVlsaLLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFI--DRSNGRKARAALREAVELLKEGEWL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 489182154 534 CIFPEGKLTADGEMNEFRAGIERIIEETPVPVIPMALQGL 573
Cdd:smart00563 79 LIFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
|
|
| LPLAT_AAK14816-like |
cd07992 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ... |
429-571 |
2.89e-18 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.
Pssm-ID: 153254 [Multi-domain] Cd Length: 203 Bit Score: 83.47 E-value: 2.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 429 MRFLVWLLSHTMYR-VRHVNLEAIPDEGAAVLVCNHV-SYVDALLIAGSIRRPVRFVMYYRIFSLPVLNFVFRTAGAVPI 506
Cdd:cd07992 1 VRLLSRVILRIYFRrITVVGRENVPKDGPVIFLGNHPnALIDPLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPV 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489182154 507 ------AARHEDEGIYERAFQRIADYLRDGELVCIFPEGKLTADGEMNEFRAGIERIIEE------TPVPVIPMALQ 571
Cdd:cd07992 81 yrpkdlARGGIGKISNAAVFDAVGEALKAGGAIGIFPEGGSHDRPRLLPLKAGAARMALEaleagqKDVKIVPVGLN 157
|
|
| AGP_acyltrn |
TIGR00530 |
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ... |
443-571 |
1.81e-17 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]
Pssm-ID: 129621 [Multi-domain] Cd Length: 130 Bit Score: 78.93 E-value: 1.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 443 VRHVNLEAIPDEGAAVLVCNHVSYVDALLIAGSIRRPVRFVMYYRIFSLPVLNFVFRTAGAVPIaARHEDEGI--YERAF 520
Cdd:TIGR00530 4 VEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFI-DRENIRAIatALKAA 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 489182154 521 QRIadyLRDGELVCIFPEGKLTADGEMNEFRAGIERIIEETPVPVIPMALQ 571
Cdd:TIGR00530 83 IEV---LKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
|
|
| PRK11195 |
PRK11195 |
lysophospholipid transporter LplT; Provisional |
94-363 |
1.44e-14 |
|
lysophospholipid transporter LplT; Provisional
Pssm-ID: 236879 [Multi-domain] Cd Length: 393 Bit Score: 76.03 E-value: 1.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 94 GIMLVGAAGFVFGSLPLMFVALFAMGthSALFGPVKYSILPQHLHEDELVGGNALVEMGTFLAILAGTIGAGVLMSHAHY 173
Cdd:PRK11195 76 GIKLLGCLLMLFGIHPLLAYGLVGIG--AAAYSPAKYGILTELLPGEKLVKANGWMEGSTIAAILLGTVLGGALADPHAE 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 174 AAAVATAVVLVAacGYLASRGIPRAAAALPGLKldWNI------FAQSWSIL-RLGLGQrpavsRSLVGNSWFWFLGAVY 246
Cdd:PRK11195 154 AALAVCALIYLL--AALFNLFIPRLGARRPGQS--WNPiallrdFFHACRVLwRDKLGR-----FSLAGTTLFWGAGATL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 247 LTQIPTFAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFG-SIGLTVFGILLwwhaggippgeapyd 325
Cdd:PRK11195 225 RFLVLAWAPVALGITLNQPAYLQAVVAIGIAVGAGAAARLVTLETVLRVLPAGiLMGLVVLLMAL--------------- 289
|
250 260 270
....*....|....*....|....*....|....*...
gi 489182154 326 wlavlrHHETWAVLADILFIGIFGGFYIVPLYALIQAR 363
Cdd:PRK11195 290 ------QHSLLPAYPLLILIGALGGFFVVPMNALLQHR 321
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
95-387 |
2.07e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.93 E-value: 2.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 95 IMLVGAAGFVFGSL--------PLMFVALFAMGTHSALFGPVKYSILPQHLHEDELVGGNALVEMGTFLAILAGTIGAGV 166
Cdd:COG2814 77 VLLLGLLLFALGSLlcalapslWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 167 LMSHAHYAAAVATAVVLVAACGYLASRGIPRAAAALPGlkldwNIFAQSWSILRlglgqRPAVSRSLVGNSWFWFLGAVY 246
Cdd:COG2814 157 LADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARA-----RLRGSLRELLR-----RPRLLLLLLLAFLLGFGFFAL 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 247 LTQIPTFAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGRkVEIGLVPFGSIGLTVFGILLWWHAGGIppgeapydw 326
Cdd:COG2814 227 FTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR-FGRRRLLLIGLLLLALGLLLLALAGSL--------- 296
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489182154 327 lavlrhhetWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFMVAA 387
Cdd:COG2814 297 ---------WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| PLN02901 |
PLN02901 |
1-acyl-sn-glycerol-3-phosphate acyltransferase |
441-572 |
3.64e-12 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferase
Pssm-ID: 215488 [Multi-domain] Cd Length: 214 Bit Score: 65.91 E-value: 3.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 441 YRVRHVNLEAIP-DEGAAVLVCNHVSYVD--ALLiagSIRRPVRFVMYYRIFSLPVLNFVFRTAGAVPIaaRHEDEGIYE 517
Cdd:PLN02901 35 YKIEVEGLENLPsPDEPAVYVSNHQSFLDiyTLF---HLGRPFKFISKTSIFLIPIIGWAMYMTGHIPL--KRMDRRSQL 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 489182154 518 RAFQRIADYLRDGELVCIFPEGKLTADGEMNEFRAGIERIIEETPVPVIPMALQG 572
Cdd:PLN02901 110 ECLKRCMELLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITLVG 164
|
|
| LPLAT |
cd06551 |
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ... |
429-611 |
3.76e-12 |
|
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).
Pssm-ID: 153244 [Multi-domain] Cd Length: 187 Bit Score: 65.51 E-value: 3.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 429 MRFLVWLLSHtMYRVRHVNLEAIPDEGAAVLVCNHVSYVDAL----LIAGSIRRPVRFVMYYriFSLPVLNFvFRTAGAV 504
Cdd:cd06551 1 FRYLLLNFFG-FVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLilflLLERGLRRDVYGLMDE--ELLERYPF-FTRLGAF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 505 PIAARHEDEGIyeRAFQRIADYLRD-GELVCIFPEGKLTADGEMN-EFRAGIERIIEETPVPVIPMALQGLWGSFFSRDP 582
Cdd:cd06551 77 SVDRDSPRSAA--KSLKYVARLLSKpGSVVWIFPEGTRTRRDKRPlQFKPGVAHLAEKAGVPIVPVALRYTFELFEQFPE 154
|
170 180
....*....|....*....|....*....
gi 489182154 583 NKGFFRRLWSRVSLVAGESVAPGAVERLD 611
Cdd:cd06551 155 IFVRIGPPIPYAETALGEELAAELANRLT 183
|
|
| LPLAT_MGAT-like |
cd07987 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ... |
441-590 |
2.46e-10 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.
Pssm-ID: 153249 [Multi-domain] Cd Length: 212 Bit Score: 60.76 E-value: 2.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 441 YRVRHV-NLEAIPDEGAAVLVCNH-VSYVDALLIAGSIR-----RPVRFVMYYRIFSLPVLNFVFRTAGAVPIAARHede 513
Cdd:cd07987 5 FRVYEVrGLENIPDEGPALLVHPHgGLPIDGALLAAAFLllfpgRLPRALADHFLFPLPGLRDLLRRLGAVPGSREN--- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 514 giyerafqrIADYLRDGELVCIFPEGKLTA-DGEMNE------FRAGIERIIEETPVPVIPMALQGL-----WGSFFSRD 581
Cdd:cd07987 82 ---------CVRLLREGELVLIFPGGAREAlKSKREEyyllwkKRKGFARLALRAGAPIVPVFTFGEeelfrVLGDPDGP 152
|
....*....
gi 489182154 582 PNKGFFRRL 590
Cdd:cd07987 153 VGKRLFRLL 161
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
93-424 |
2.60e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.43 E-value: 2.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 93 VGIMLVGAAGFVFG---SLPLMFVALFAMGTHSALFGPVKYSILPQHLHEDELVGGNALVEMGTFLAILAGTIGAGVLMS 169
Cdd:cd17325 66 LGLLLLAVSTLLFAfatSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 170 HAHYAAAVATAVVLVAACGYLASRGIPRAAAALPGLKLDWNIFAQSWSILRLglgqRPAVSRSLVGNSWFWFLGAVYLTQ 249
Cdd:cd17325 146 ALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLR----DRRLLALFLAIFVLAFAFGALEPF 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 250 IPTFAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSIgLTVFGILLWWHAGGIppgeapydwlav 329
Cdd:cd17325 222 LPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL-LSAVALLLLPLATSF------------ 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 330 lrhhetWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFMVAAALVSILFlsVAKLSIPQLFLAL 409
Cdd:cd17325 289 ------WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL--YDAFGFATPFLAA 360
|
330
....*....|....*
gi 489182154 410 SLMNVAVNVYIFKIV 424
Cdd:cd17325 361 AALLLLAAVLFLLLR 375
|
|
| LPLAT_LPCAT1-like |
cd07991 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ... |
429-571 |
8.40e-08 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.
Pssm-ID: 153253 [Multi-domain] Cd Length: 211 Bit Score: 52.99 E-value: 8.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 429 MRFLVWLLSHtmYRVRHVNLEAiPDEGAAVLVCNHVSYVDALLIagSIRRPVRFVMYYRIFSLPVLNFVFRTAGAVPIaa 508
Cdd:cd07991 1 ARVLLFAFGF--YVIKVHGKPD-PPEAPRIIVANHTSFIDPLIL--FSDLFPSIVAKKELGKLPFIGTILRALGCIFV-- 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489182154 509 RHEDEGIYERAFQRIADYLRDGEL--VCIFPEGKLTADGEMNEFRAGieriIEETPVPVIPMALQ 571
Cdd:cd07991 74 DRSEPKDRKKVVEEIKERATDPNWppILIFPEGTTTNGKALIMFKKG----AFEPGVPVQPVAIR 134
|
|
| LPLAT_ACT14924-like |
cd07986 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ... |
441-572 |
1.79e-07 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.
Pssm-ID: 153248 [Multi-domain] Cd Length: 210 Bit Score: 52.25 E-value: 1.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 441 YRVRHVNLEAIPDEGAAVLVCNH-VSYVDALL---IAGSIRRPVRFVMYYRIFSLPVLNFVFrtagaVPIAARHEDEGIY 516
Cdd:cd07986 8 LEVDVSGLENIPKDGPVVIVANHpFGILDGLIladLLGSVRPDVRILANQLLSKIPELRDLF-----IPVDPLEGRAALA 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489182154 517 E--RAFQRIADYLRDGELVCIFPEGKL-TADGEMNEFR-----AGIERIIEETPVPVIPMALQG 572
Cdd:cd07986 83 KnrESLREALRHLKNGGALIIFPAGRVsTASPPFGRVSdrpwnPFVARLARKAKAPVVPVYFSG 146
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
86-414 |
9.02e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 51.66 E-value: 9.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 86 RALKLAEVGIMLVGAAGFVFGSLPLMFVALFAMGTHSALFGPVKYSILPQHLHEDELVGGNALVEMGTFLAILAGTIGAG 165
Cdd:cd06174 62 PVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 166 VLMSHAHYA-AAVATAVVLVAACGYLASRGIPRAAAALPGLKLDWNIFAQSWSILRLgLGQRPAVSRSLVGNSWFWFLGA 244
Cdd:cd06174 142 ILASSLGFGwRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKR-VLKNPGLWLLLLAIFLVNLAYY 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 245 VYLTQIPTFAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSIGLTVFGILLWWHAGGippgeapy 324
Cdd:cd06174 221 SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPS-------- 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 325 dwlavlrhheTWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFMVAAALVSIlFLSVAKLSIPQ 404
Cdd:cd06174 293 ----------LLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG-FLLAATFGLTG 361
|
330
....*....|
gi 489182154 405 LFLALSLMNV 414
Cdd:cd06174 362 AFLVLAVLLL 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
95-388 |
3.36e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.34 E-value: 3.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 95 IMLVGAAGFVFG--------SLPLMFVALFAMGTHSALFGPVKYSILPQHLHEDELVGGNALVEMGTFLAILAGTIGAGV 166
Cdd:pfam07690 64 VLLIGLLLFALGlllllfasSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 167 LMSHAHYAAAVATAVVLVAACGYLASRGIPRAAAALP-GLKLDWNIFAQSWSILRlglgqRPAVSRSLVGNSWFWFLGAV 245
Cdd:pfam07690 144 LASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPkPAEEARLSLIVAWKALL-----RDPVLWLLLALLLFGFAFFG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 246 YLTQIPTFAKEwLHGDESVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSIGLTVFGILLWWHAGGippgeapyd 325
Cdd:pfam07690 219 LLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLT--------- 288
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489182154 326 wlavlrhHETWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFMVAAA 388
Cdd:pfam07690 289 -------LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| PRK08043 |
PRK08043 |
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase; |
430-596 |
3.52e-06 |
|
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
Pssm-ID: 181207 [Multi-domain] Cd Length: 718 Bit Score: 50.09 E-value: 3.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 430 RFLVWLLSHtMYRVRHVNLEAIPDEGAAVLVCNHVSYVDALLIAgsIRRPVR--FVMYYRIFSLPVLNFVFRTAGAVPIa 507
Cdd:PRK08043 4 SFFRNLFRV-LYRVRVTGDTQALKGERVLITPNHVSFLDGILLA--LFLPVRpvFAVYTSISQQWYMRWLKPYIDFVPL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 508 arhedEGIYERAFQRIADYLRDGELVCIFPEGKLTADGEMNEFRAGIERIIEETPVPVIPMALQGLWGSFFSRdpNKGFF 587
Cdd:PRK08043 80 -----DPTKPMAIKHLVRLVEQGRPVVIFPEGRITVTGSLMKIYDGAGFVAAKSGATVIPVRIEGAELTHFSR--LKGLV 152
|
170
....*....|
gi 489182154 588 -RRLWSRVSL 596
Cdd:PRK08043 153 kRRLFPQITL 162
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
225-426 |
1.13e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 225 QRPAVSRSLVGNSWFWFLGAVYLTQIPTFAKEwLHGDESVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSIGLT 304
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 305 VFGILLWWHAGgippgeapYDWLAVLRhhetwavladiLFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFM 384
Cdd:COG2814 87 LGSLLCALAPS--------LWLLLAAR-----------FLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP 147
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 489182154 385 VAAALVSILFLSVakLSIPQLFLALSLMNVAVNVYIFKIVPE 426
Cdd:COG2814 148 ALGPLLGGLLADL--FGWRWVFLVNAVLALLALLLLLRLLPE 187
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
231-398 |
1.19e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 231 RSLVGNSWFWFLGAVYLTQ----------IPTFAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGRkveIGLVPFGS 300
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFflalalvaalLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR---FGKKKAFI 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 301 IGLTVFGILLWwhaggippgeapydWLAVLRHHETWAVLADILFIGIFGGFYIVPLYALI-------QARTDEDKRARVI 373
Cdd:COG2211 299 IGLLLAALGLL--------------LLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadvvdydEWKTGRRREGLYF 364
|
170 180
....*....|....*....|....*
gi 489182154 374 AANNILNALFMVAAALVSILFLSVA 398
Cdd:COG2211 365 GIFTFAIKLGQALAGALAGLLLALF 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
93-394 |
2.06e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.09 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 93 VGIMLVGAAGFVFG---SLPLMFVALFAMGTHSALFGPVKYSILPQHLHEDELVGGNALVEMGTFLAILAGTIGAGVLMS 169
Cdd:COG2271 80 IGLLLWGLATLLFGfatSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 170 HAHYaaavatavvlvaacgylasrgipRAAAALPGlkldwnIFAQSWSILRLGLGqrpavsrsLVGNSWFWFLGAVYLTQ 249
Cdd:COG2271 160 AFGW-----------------------RAAFLILG------LPGLLLALLRFWLL--------ALAYFLVYFALYGFLTW 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 250 IPTFAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGR-KVEIGLVPFGSIGLTVFGILLWWHAGGippgeapydwla 328
Cdd:COG2271 203 LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlGRRRKLVLAIGLLLAALALLLLALLPS------------ 270
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489182154 329 vlrhheTWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAannILNALFMVAAALVSILF 394
Cdd:COG2271 271 ------PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASG---LVNTFGFLGGALGPLLV 327
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
239-426 |
2.87e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.56 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 239 FWFLGAVYLTQIPTFAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGRkveIGLVPFGSIGLTVFGILLwwhaggip 318
Cdd:pfam07690 8 AALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---FGRRRVLLIGLLLFALGL-------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 319 pgeapydwLAVLRHHETWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFMVAAALVSILFLSVa 398
Cdd:pfam07690 77 --------LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL- 147
|
170 180
....*....|....*....|....*...
gi 489182154 399 kLSIPQLFLALSLMNVAVNVYIFKIVPE 426
Cdd:pfam07690 148 -FGWRAAFLILAILSLLAAVLLLLPRPP 174
|
|
| LPLAT_LCLAT1-like |
cd07990 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ... |
457-539 |
4.13e-04 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.
Pssm-ID: 153252 [Multi-domain] Cd Length: 193 Bit Score: 41.84 E-value: 4.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 457 AVLVCNHVSYVDALLI------AGSIRRpVRFVMYYRIFSLPVLNFVFRTAGAVPIAARHE-DEGIYERAFQRIADYlRD 529
Cdd:cd07990 26 ALIISNHRSEVDWLVLwmladrFGRLGR-LKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWEkDEKTIKRQLKRLKDS-PE 103
|
90
....*....|
gi 489182154 530 GELVCIFPEG 539
Cdd:cd07990 104 PFWLLIFPEG 113
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
248-416 |
7.49e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 42.18 E-value: 7.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 248 TQIPTFAKEWLHGDESVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSIgLTVFGILLWWHAGGIppgeapydwl 327
Cdd:cd17473 218 IQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFA-LMALGFLLLALASGL---------- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 328 avlrhhetWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFMVAAALVSIlFLSVAKLSIPQLFL 407
Cdd:cd17473 287 --------WVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLG-PLVNLTGGLSGAFL 357
|
....*....
gi 489182154 408 ALSLMNVAV 416
Cdd:cd17473 358 ILGVLALVL 366
|
|
| COG3176 |
COG3176 |
Putative hemolysin [General function prediction only]; |
441-578 |
9.21e-04 |
|
Putative hemolysin [General function prediction only];
Pssm-ID: 442409 Cd Length: 270 Bit Score: 41.56 E-value: 9.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 441 YRVRHVNLEAIPDEGAAVLVCNH-VSYVDALL---IAGSIRRPvrfvmyYRIFSlpvlNFVFRTAgavpiaarheDEGIY 516
Cdd:COG3176 57 LEVPEGDLDRIDADGHLLVVANHpLGILDGLAllkLVGTVRPD------YRILA----NDLALRI----------PGGFY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 517 E-----------RAFQRIADYLRDGELVCIFPegkltaDGEMNEFRAGIE--------RIIEETPVPVIPMALQGLWGSF 577
Cdd:COG3176 117 SelefpvdpfnlETLKAARRHLLEGGRSCVFP------AGRVSGARRVIDllwsglaaKLARKAGAPVVPVYFDGRNSGL 190
|
.
gi 489182154 578 F 578
Cdd:COG3176 191 F 191
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
239-430 |
2.50e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.67 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 239 FWFLGAVYLTQIptfakewLHGDESVVTLILTVFSVGIALGSMLCEKLSGRkveiglvpFGSIGLTVFGILLWwhAGGIp 318
Cdd:cd17329 18 VWPFMAIYLHQQ-------LGLSASIVGLVLALSAVAGIVASLIGGRLADR--------FGRKPVMLAGLLLR--ALGF- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489182154 319 pgeapydwLAVLRHHETWAVLADILFIGIFGGFYIVPLYALIQARTDEDKRARVIAANNILNALFMVAAALVSILFLsva 398
Cdd:cd17329 80 --------ALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL--- 148
|
170 180 190
....*....|....*....|....*....|..
gi 489182154 399 KLSIPQLFLALSLMNVAVNVYIFKIVPEFTMR 430
Cdd:cd17329 149 LYSFRLLFLAAAVLFLLAALVLLFLLPETRPK 180
|
|
| |
