|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
13-436 |
2.08e-107 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 324.51 E-value: 2.08e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 13 THHRVWALAGPMILSNVSVPLVHLVDSTVVGHLPHAYQLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALR 92
Cdd:cd13136 1 LHREILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 93 LILAQGLGMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILL 172
Cdd:cd13136 81 ALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 173 TTNLSNIALVLWFVHGLDWGVQGAARASVLAEWSGALLGLALTRRdLARRPGRAQWQRLRHWLSWLPLLMVNRDIFIRSL 252
Cdd:cd13136 161 VGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRR-RVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 253 ALQLVFFLLTVQGTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDRAALRRALVVAGGWSLLASLAFA 332
Cdd:cd13136 240 ALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 333 ALFALFGHLFIDLQSDIAGVREVAYAYLPYLACLPLLGMWSYLLDGLFIGATRAREMRNAMLVAVAASLPLGWLLQGL-G 411
Cdd:cd13136 320 LLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPLLFLLVPLwG 399
|
410 420
....*....|....*....|....*
gi 489185907 412 NHGLWLAFLAFMLLRGLVLAAYGWR 436
Cdd:cd13136 400 NHGLWLALILFMLLRGLTLALRLPR 424
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
12-446 |
3.22e-82 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 260.44 E-value: 3.22e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 12 PTHHRVWALAGPMILSNVSVPLVHLVDSTVVGHLPHAYQLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGAL 91
Cdd:PRK10367 6 SSDKALWRLALPMIFSNITVPLLGLVDTAVIGHLDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 92 RLILAQGLGMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAIL 171
Cdd:PRK10367 86 ARALVQPLLLALGAGALIALLRTPLIDLALHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVILL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 172 LTTNLSNIALVLWFVHGLDWGVQGAARASVLAEWSGALLGLALTRRDLARRpGRAQWQRLRHWLSWL-PLLMVNRDIFIR 250
Cdd:PRK10367 166 VVGNILNIVLDLWLVMGLHMNVQGAALATVIAEYATLLIGLLMVRKVLKLR-GISLEMLKTAWRGNFrRLLALNRDIMLR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 251 SLALQLVFFLLTVQGTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDRAALRRALVVAGGWSLLASLA 330
Cdd:PRK10367 245 SLLLQLCFGAITVLGARLGSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSGQAYGARDGSQLLDVWRAACRQSGIVALL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 331 FAALFALFGHLFIDLQSDIAGVREVAYAYLPYLACLPLLGMWSYLLDGLFIGATRAREMRNAMLVAVAASLPLGWLLQGL 410
Cdd:PRK10367 325 FSLVYALAGEHIIALLTSLPQIQQLADRYLIWQVILPLVGVWCYLLDGMFIGATRAAEMRNSMAVAAAGFALTLLTLPWL 404
|
410 420 430
....*....|....*....|....*....|....*.
gi 489185907 411 GNHGLWLAFLAFMLLRGLVLAAYGWRLTRRDGWFAA 446
Cdd:PRK10367 405 GNHGLWLALTVFLALRGLSLAAIWRRHWRNGTWFAA 440
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
10-433 |
5.19e-62 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 207.30 E-value: 5.19e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 10 HAPTHHRVWALAGPMILSNVSVPLVHLVDSTVVGHLpHAYQLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGG 89
Cdd:COG0534 3 EGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRL-GTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDRE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 90 ALRLILAQGLGMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLA 169
Cdd:COG0534 82 EARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 170 ILLTTNLSNIALVLWFVHGLDWGVQGAARASVLAEWSGALLGLALTRRDlaRRPGRAQWQRLR-HWLSWLPLLMVNRDIF 248
Cdd:COG0534 162 IMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRK--RSLLRLRLRDLRpDRKILKRILRIGLPAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 249 IRSLALQLVFFLLTVQGTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDRAALRRALVVAGGWSLLAS 328
Cdd:COG0534 240 LQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 329 LAFAALFALFGHLFIDLQSDIAGVREVAYAYLPYLACLPLLGMWSYLLDGLFIGATRAREMRNAMLVA-VAASLPLGWLL 407
Cdd:COG0534 320 LLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRlWLVRLPLAYLL 399
|
410 420
....*....|....*....|....*...
gi 489185907 408 --QGLGNHGLWLAFLAFMLLRGLVLAAY 433
Cdd:COG0534 400 afLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
23-364 |
3.22e-31 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 122.74 E-value: 3.22e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 23 PMILSNVSVPLVHLVDSTVVGHLPHAYqLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALRLILAQGLGMA 102
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVD-LAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 103 LLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTNLSNIALV 182
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 183 LWFVHGL--DWGVQGAARASVLAEWSGALLGLALTRRdLARRPGRAQWQRLRHWLSWLPLLMVNRDIFIRSLALQLVFFL 260
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKK-AKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 261 LTVQGTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDRAALRRALVVAGGWSLLASLAFAALFALFGH 340
Cdd:TIGR00797 239 LALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFRE 318
|
330 340
....*....|....*....|....
gi 489185907 341 LFIDLQSDIAGVREVAYAYLPYLA 364
Cdd:TIGR00797 319 FIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
23-181 |
1.65e-09 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 56.42 E-value: 1.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 23 PMILSNVSVPLVHLVDSTVVGHLPhAYQLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALRLILAQGLGMA 102
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLG-AVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489185907 103 LLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTNLSNIAL 181
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPL 158
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
13-436 |
2.08e-107 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 324.51 E-value: 2.08e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 13 THHRVWALAGPMILSNVSVPLVHLVDSTVVGHLPHAYQLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALR 92
Cdd:cd13136 1 LHREILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 93 LILAQGLGMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILL 172
Cdd:cd13136 81 ALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 173 TTNLSNIALVLWFVHGLDWGVQGAARASVLAEWSGALLGLALTRRdLARRPGRAQWQRLRHWLSWLPLLMVNRDIFIRSL 252
Cdd:cd13136 161 VGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRR-RVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 253 ALQLVFFLLTVQGTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDRAALRRALVVAGGWSLLASLAFA 332
Cdd:cd13136 240 ALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 333 ALFALFGHLFIDLQSDIAGVREVAYAYLPYLACLPLLGMWSYLLDGLFIGATRAREMRNAMLVAVAASLPLGWLLQGL-G 411
Cdd:cd13136 320 LLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPLLFLLVPLwG 399
|
410 420
....*....|....*....|....*
gi 489185907 412 NHGLWLAFLAFMLLRGLVLAAYGWR 436
Cdd:cd13136 400 NHGLWLALILFMLLRGLTLALRLPR 424
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
12-446 |
3.22e-82 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 260.44 E-value: 3.22e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 12 PTHHRVWALAGPMILSNVSVPLVHLVDSTVVGHLPHAYQLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGAL 91
Cdd:PRK10367 6 SSDKALWRLALPMIFSNITVPLLGLVDTAVIGHLDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 92 RLILAQGLGMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAIL 171
Cdd:PRK10367 86 ARALVQPLLLALGAGALIALLRTPLIDLALHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVILL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 172 LTTNLSNIALVLWFVHGLDWGVQGAARASVLAEWSGALLGLALTRRDLARRpGRAQWQRLRHWLSWL-PLLMVNRDIFIR 250
Cdd:PRK10367 166 VVGNILNIVLDLWLVMGLHMNVQGAALATVIAEYATLLIGLLMVRKVLKLR-GISLEMLKTAWRGNFrRLLALNRDIMLR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 251 SLALQLVFFLLTVQGTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDRAALRRALVVAGGWSLLASLA 330
Cdd:PRK10367 245 SLLLQLCFGAITVLGARLGSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSGQAYGARDGSQLLDVWRAACRQSGIVALL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 331 FAALFALFGHLFIDLQSDIAGVREVAYAYLPYLACLPLLGMWSYLLDGLFIGATRAREMRNAMLVAVAASLPLGWLLQGL 410
Cdd:PRK10367 325 FSLVYALAGEHIIALLTSLPQIQQLADRYLIWQVILPLVGVWCYLLDGMFIGATRAAEMRNSMAVAAAGFALTLLTLPWL 404
|
410 420 430
....*....|....*....|....*....|....*.
gi 489185907 411 GNHGLWLAFLAFMLLRGLVLAAYGWRLTRRDGWFAA 446
Cdd:PRK10367 405 GNHGLWLALTVFLALRGLSLAAIWRRHWRNGTWFAA 440
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
10-433 |
5.19e-62 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 207.30 E-value: 5.19e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 10 HAPTHHRVWALAGPMILSNVSVPLVHLVDSTVVGHLpHAYQLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGG 89
Cdd:COG0534 3 EGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRL-GTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDRE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 90 ALRLILAQGLGMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLA 169
Cdd:COG0534 82 EARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 170 ILLTTNLSNIALVLWFVHGLDWGVQGAARASVLAEWSGALLGLALTRRDlaRRPGRAQWQRLR-HWLSWLPLLMVNRDIF 248
Cdd:COG0534 162 IMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRK--RSLLRLRLRDLRpDRKILKRILRIGLPAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 249 IRSLALQLVFFLLTVQGTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDRAALRRALVVAGGWSLLAS 328
Cdd:COG0534 240 LQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 329 LAFAALFALFGHLFIDLQSDIAGVREVAYAYLPYLACLPLLGMWSYLLDGLFIGATRAREMRNAMLVA-VAASLPLGWLL 407
Cdd:COG0534 320 LLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRlWLVRLPLAYLL 399
|
410 420
....*....|....*....|....*...
gi 489185907 408 --QGLGNHGLWLAFLAFMLLRGLVLAAY 433
Cdd:COG0534 400 afLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
23-364 |
3.22e-31 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 122.74 E-value: 3.22e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 23 PMILSNVSVPLVHLVDSTVVGHLPHAYqLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALRLILAQGLGMA 102
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVD-LAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 103 LLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTNLSNIALV 182
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 183 LWFVHGL--DWGVQGAARASVLAEWSGALLGLALTRRdLARRPGRAQWQRLRHWLSWLPLLMVNRDIFIRSLALQLVFFL 260
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKK-AKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 261 LTVQGTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDRAALRRALVVAGGWSLLASLAFAALFALFGH 340
Cdd:TIGR00797 239 LALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFRE 318
|
330 340
....*....|....*....|....
gi 489185907 341 LFIDLQSDIAGVREVAYAYLPYLA 364
Cdd:TIGR00797 319 FIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
21-435 |
6.17e-25 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 106.25 E-value: 6.17e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 21 AGPMILSNVSVPLVHLVDSTVVGHLPHAYqLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALRLILAQGLG 100
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDA-LAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 101 MALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTNLSNIA 180
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 181 LVLWFVHGL---DWGVQGAARASVLAEWSGALLGLALTRRDLARRPGRAQWQRLRhWLSWLPLLMVNRDIFIRSLALQLV 257
Cdd:cd12082 160 LDPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPD-LELLRRLLRIGLPSAIQNSLLSLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 258 FFLLT-VQGTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDRAALRRALVVAGGWSLLASLAFAALFA 336
Cdd:cd12082 239 LLIIVaIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 337 LFGHLFIDLQSDIAGVREVAYAYLPYLACLPLLGMWSYLLDGLFIGATRARE-MRNAMLVAVAASLPLGWLLQ--GLGNH 413
Cdd:cd12082 319 LFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKsLIVSLLSYWVVRLPLAYVLAylGLGLY 398
|
410 420
....*....|....*....|..
gi 489185907 414 GLWLAFLAFMLLRGLVLAAYGW 435
Cdd:cd12082 399 GIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-433 |
7.56e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 94.52 E-value: 7.56e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 16 RVWALAGPMILSNVSVPLVHLVDSTVVGHLpHAYQLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALRLIL 95
Cdd:cd13133 6 EILKIALPLVLSMLSQTVMGFTDRAFLGRL-SEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 96 AQGLGMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTN 175
Cdd:cd13133 85 WQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 176 LSNIALVLWFVHG----LDWGVQGAARASVLAEWSGALLGLALTRRdlarrpgRAQWQRLRHWLSWLPllmvNRDIFIRS 251
Cdd:cd13133 165 VVNIVLDYALIFGklgfPAMGIAGAAIATVIAEAVSLLFFLLLLFR-------RKNRRRFGLRRAWRF----DRELLRRI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 252 LALQL-----------VFFLLTVQGTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDRAALRRALVVA 320
Cdd:cd13133 234 LRLGLpsglqffldvgAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 321 GGWSLLASLAFAALFALFGHLFIDLQSDIAGVREVAYAYLPYLACLPLlgmwSYLLDGLFI---------GATRAReMRN 391
Cdd:cd13133 314 LKLALAYMLLLGILFLLFPELLLSIFTPGADFALIAELAVPLLRFVAA----YILFDALALvfagalrgaGDTRFV-MLA 388
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 489185907 392 AMLVAVAASLPLGWLL--QGLGNHGLWLAFLAFMLLRGLVLAAY 433
Cdd:cd13133 389 ELIVAWLYLLPPAYLLvvLGAGLAGAWTVETVYVIVLALIFLLR 432
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
15-443 |
6.84e-18 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 85.26 E-value: 6.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 15 HRVWALAGPMILSNVSVPLVHLVDSTVVGHL-PHAyqLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALRL 93
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLgAEA--IAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 94 ILAQGLGMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLT 173
Cdd:cd13137 79 ALGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 174 TNLSNIALVLWFVHGL----DWGVQGAARASVLAEWSGALLGLALTRRdlaRRPGraqwqRLRHWLSWLPLLMVNRDIF- 248
Cdd:cd13137 159 VNVLNIVLDYVLIFGLwgfpGLGVAGAALATVISRVVGALLLLFLLLR---GRLP-----IKISFKGFRLDRKIIKKLLr 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 249 ------IRSLALQLVFFLLTVQGTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDRAALRRALVVAGG 322
Cdd:cd13137 231 iglpagLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALR 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 323 WSLLASLAFAALFALFGHLFIDLQSDIAGVREVAYAYLPYLA-CLPLLGMwSYLLDGLFIGATrareMRNAMLVAVAAS- 400
Cdd:cd13137 311 LGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVAlSQPFLAI-SFVLSGALRGAG----DTRPPLIINLISm 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 489185907 401 ----LPLGWLL---QGLGNHGLWLAFLAFMLLRGLVLaaygWRLTRRDGW 443
Cdd:cd13137 386 wlvrLPLAYLLgfvLGLGLTGIWLAMFVDTIVRAILL----LYRFRKGKW 431
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
20-217 |
4.57e-15 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 76.73 E-value: 4.57e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 20 LAGPMILSNVSVPLVHLVDSTVVGHLPHAYQLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALRLILAQGL 99
Cdd:cd13138 8 FALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGTLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 100 GMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTNLSNI 179
Cdd:cd13138 88 VLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIACVLNI 167
|
170 180 190
....*....|....*....|....*....|....*...
gi 489185907 180 ALVLWFVHGLDWGVQGAARASVLAEWSGALLGLALTRR 217
Cdd:cd13138 168 ILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRK 205
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
18-232 |
2.00e-14 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 74.84 E-value: 2.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 18 WALAGPMILSNVSVPLVHLVDSTVVGHLpHAYQLGAVAVGGSLY-TLMVGVLGFLrMGTTGFAAQAAGRDDGGALRLILA 96
Cdd:cd13131 6 LRLALPILIAQLAQMAMGFVDTVMAGRL-GADDLAAVALGSSLWfPVFTFGMGLL-LAVTPLVAQAHGAGDRRRIRRAVR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 97 QGLGMALLLALLLGALALPlSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTNL 176
Cdd:cd13131 84 QGLWLALLLSLPLMLLLWL-APPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALV 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489185907 177 SNIALVLWFVHGL----DWGVQGAARASVLAEWSGALLGLALTRRD-------LARRPGRAQWQRLR 232
Cdd:cd13131 163 LNIPLNYVLIFGKfglpALGGAGAGLATAIVYWLMFLALAFYIRRHkrfrryrLFARFWRPDWARLK 229
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
18-431 |
9.20e-11 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 63.30 E-value: 9.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 18 WALAGPMILSNVSVPLVHLVDSTVVGHLPHAYQLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALRLILAQ 97
Cdd:cd13143 7 LKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIFST 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 98 GLGMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTNLS 177
Cdd:cd13143 87 ALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 178 NIALVLWFVHGLDWGVQGAARASVLAEWSGALLGLALTRRDLARRPGRAQWQRLRhWLSWLPLLMVNRDIFIRSLALQLV 257
Cdd:cd13143 167 NIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLS-LKIIKEILALGFPSFLMQLSSSVV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 258 FFLLTVQ-GTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDR----AALRRALVVAGGWSLLASLAFA 332
Cdd:cd13143 246 TIVLNLTlLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYdrvkQALKLALIVALIYGLVLFLILL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 333 ALFALFGHLFIDlqsDIAGVREVAYAYLPYLACLPLLGMwSYLLDGLFIGATRAremRNAMLVAVAAS----LPLGWLL- 407
Cdd:cd13143 326 LFPEQIVSLFTD---DPELIALAARILRIFLLAFPLAGI-NIVLSGYFQAIGKA---KRAALLSLLRQglflIPLLLILp 398
|
410 420
....*....|....*....|....*
gi 489185907 408 QGLGNHGLWLAF-LAFMLLRGLVLA 431
Cdd:cd13143 399 RLFGLDGIWLAFpLAEILTLLLALI 423
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
23-181 |
1.65e-09 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 56.42 E-value: 1.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 23 PMILSNVSVPLVHLVDSTVVGHLPhAYQLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALRLILAQGLGMA 102
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLG-AVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489185907 103 LLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTNLSNIAL 181
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPL 158
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
16-241 |
2.35e-08 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 56.04 E-value: 2.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 16 RVWALAGPMILSNVSVPLVHLVDSTVVGHLPHAYqLGAVAVGGSLYTLM-VGVLGFLRMGTTGFAAQAAGRDDGGALRLI 94
Cdd:cd13132 4 KLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLE-LAAASLASSFANVTgFSILLGLASALDTLCGQAFGAKNYKLVGVY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 95 LaQGLGMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAAlASYALVGWFLGTQNARAPLA-ILLT 173
Cdd:cd13132 83 L-QRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAY-ALFEPLKRYLQAQGIVLPLVyISLV 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489185907 174 TNLSNIALVLWFVHGLDWGVQGAARASVLAEWSGALLGLALTRrdlaRRPGRAQWQRLRHWL---SWLPLL 241
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIF----FSKGHKATWGGFSREafrGWGPFL 227
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-228 |
6.52e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 48.27 E-value: 6.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 17 VWALAGPMILSNVSVPLVHLVDSTVVGHLPHAYqLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALRLILA 96
Cdd:cd13134 5 LFALAWPIFIELLLQMLLGTIDTFMLSRYSDNA-VAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 97 QGLGMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTNL 176
Cdd:cd13134 84 VALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNI 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 489185907 177 SNIALVLWFVHGL----DWGVQGAARASVLAEWSGALLGLALTRRDLARRPGRAQW 228
Cdd:cd13134 164 LNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDL 219
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-419 |
2.82e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 46.42 E-value: 2.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 20 LAGPMILSNVSVPLVHLVDSTVVGHLphayqlGAVAVGG------SLYTLMVGVLGFLRMGTTgFAAQAAGRDDGGALRL 93
Cdd:cd13142 16 LAWPIIVSNLLQVAYNLADTFWLGRL------GADAVAApsiswpLIFLFISLGGGLTVAGTA-LVAQYTGAGDYDKANK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 94 ILAQGLGMALLLALLLGALALPLSG-WALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILL 172
Cdd:cd13142 89 VAGQTFSFVIILSLILAVLGYILSRpLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 173 TTNLSNIALVLWFVHGL----DWGVQGAARASVLAEWSGALLGLALTRRDlaRRPGRAQWQRLRHWLSWLPLLM-VNRDI 247
Cdd:cd13142 169 GSVLLNVILDPLLIFGIgpfpGLGVAGAALATVISRGIAAVIGLYLLFKG--RVGLKISLRDLKPDWEWLKKIFrIGLPS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 248 FIRSLALQLVFFLLTVQGTRLGDATVAANALLLNGLLLTSYALDGLAHAVEALCGHAIGARDRAALRRALVVAGGWSLLA 327
Cdd:cd13142 247 SIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 328 SLAFAALFALFGHLFIDLQSDIAGVREVAYAYLPYLA-CLPLLGMWSyLLDGLFIGATRareMRNAMLVAVAA----SLP 402
Cdd:cd13142 327 LVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVApSFPFFGLFQ-VINGAFRGSGH---TLTAMIISILRlwviRIP 402
|
410 420
....*....|....*....|
gi 489185907 403 LGWLL---QGLGNHGLWLAF 419
Cdd:cd13142 403 LAYLLayvLGLGVTGIWIAM 422
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
127-218 |
9.86e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 41.36 E-value: 9.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 127 SAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTNLSNIALVLWFVHGLD----WGVQGAARASVL 202
Cdd:cd13140 117 DAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVL 196
|
90
....*....|....*.
gi 489185907 203 AEWSGALLGLALTRRD 218
Cdd:cd13140 197 AQAIVFLLFLYALKKK 212
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
51-209 |
1.50e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 40.66 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 51 LGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALRLILAQGLGMALLLALLLGALALPLSGWALQLMQPSAEL 130
Cdd:cd13145 44 LAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDY 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 131 TGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTNLSNIALVLWFVHG----LDWGVQGAARASVLAEWS 206
Cdd:cd13145 124 LDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFLNIILDPLFIFGgggiPAMGVSGIALATIISQFI 203
|
...
gi 489185907 207 GAL 209
Cdd:cd13145 204 GMF 206
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-231 |
3.12e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 39.61 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 20 LAGPMILSNVSVPLVHLVDSTVVGHLPHAyQLGAVAVGGSLYTLMVGVLGFLRMGTTGFAAQAAGRDDGGALRLILAQGL 99
Cdd:cd13141 16 MALPIAIGMIIQTLYFLVDLYFVGQLGDA-ALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVFNQSL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185907 100 GMALLLALLLGALALPLSGWALQLMQPSAELTGEARAFFHTRLLGLPAALASYALVGWFLGTQNARAPLAILLTTNLSNI 179
Cdd:cd13141 95 LLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAVLLNI 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489185907 180 A----LVLWFVHGLDWGVQGAARASVLAEWSGALLGLA--------LTRRDLARRPGRAQWQRL 231
Cdd:cd13141 175 IlapiLITGWGTGRALGVAGAGLASSISVAIAVVLLLYyflrlekyLRLDLALWRPDLPTWKRL 238
|
|
| |
