|
Name |
Accession |
Description |
Interval |
E-value |
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
6-356 |
7.93e-154 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 436.59 E-value: 7.93e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 6 LHRLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTESPEALNSLRQAVEQAHPFTKREATLTSIT 85
Cdd:COG3852 8 LLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRELLERALAEGQPVTEREVTLRRKD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 86 GVSITVDYAVTPILNRN-ETLLLLEVHPRDRLMRITREEAQLSKQETTKLLVRGLAHEIKNPLGGIRGAAQLLSRELPEE 164
Cdd:COG3852 88 GEERPVDVSVSPLRDAEgEGGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLERELPDD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 165 SLKDYTNVIIEEADRLRNLVDRMLGSNK--LPNLAPTNIHEVLERVSSLVEAESQGSITLVRDYDPSIPDLLLDREQMIQ 242
Cdd:COG3852 168 ELREYTQLIIEEADRLNNLVDRLLSFSRprPPEREPVNLHEVLERVLELLRAEAPKNIRIVRDYDPSLPEVLGDPDQLIQ 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 243 AVLNMVRNAMQAIAGQndlrlGRITLRSRTLRQFTIGHTRHRLVCKVEIIDNGPGIPAELQETIFYPMVSGRPDGTGLGL 322
Cdd:COG3852 248 VLLNLVRNAAEAMPEG-----GTITIRTRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGL 322
|
330 340 350
....*....|....*....|....*....|....*
gi 489186619 323 AIAQNIISQHQGLIECESHPG-HTVFSLFLPLEQG 356
Cdd:COG3852 323 AIVQKIVEQHGGTIEVESEPGkGTTFRIYLPLEQA 357
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
1-353 |
2.19e-141 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 404.85 E-value: 2.19e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 1 MPTDTLH--RLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTESPEALNSLRQAVEQAHPFTKRE 78
Cdd:PRK11073 1 MATGTLPdaGQILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMRESLQAGQGFTDNE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 79 ATLTsITGVSITVDYAVTPIlnrNETLLLLEVHPRDRLMRITREEAQLSKQETTKLLVRGLAHEIKNPLGGIRGAAQLLS 158
Cdd:PRK11073 81 VTLV-IDGRSHILSLTAQRL---PEGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 159 RELPEESLKDYTNVIIEEADRLRNLVDRMLGSNKLPNLAPTNIHEVLERVSSLVEAESQGSITLVRDYDPSIPDLLLDRE 238
Cdd:PRK11073 157 KALPDPALTEYTKVIIEQADRLRNLVDRLLGPQRPGTHVTESIHKVAERVVQLVSLELPDNVRLIRDYDPSLPELAHDPD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 239 QMIQAVLNMVRNAMQAIAGQNdlrlGRITLRSRTLRQFTIGHTRHRLVCKVEIIDNGPGIPAELQETIFYPMVSGRPDGT 318
Cdd:PRK11073 237 QIEQVLLNIVRNALQALGPEG----GTITLRTRTAFQLTLHGERYRLAARIDIEDNGPGIPPHLQDTLFYPMVSGREGGT 312
|
330 340 350
....*....|....*....|....*....|....*
gi 489186619 319 GLGLAIAQNIISQHQGLIECESHPGHTVFSLFLPL 353
Cdd:PRK11073 313 GLGLSIARNLIDQHSGKIEFTSWPGHTEFSVYLPI 347
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
10-358 |
1.11e-70 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 226.77 E-value: 1.11e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 10 LLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTESPEAlNSLRQAVEQAhpftkREATLTSITGVSI 89
Cdd:COG5000 95 ILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLA-ELLREALERG-----WQEEIELTRDGRR 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 90 TVDYAVTPILNRNETLLLLEVhprdrlmritREEAQLSKQETTKLLVRGLAHEIKNPLGGIRGAAQLLSRELPE------ 163
Cdd:COG5000 169 TLLVRASPLRDDGYVIVFDDI----------TELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADkleedr 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 164 ESLKDYTNVIIEEADRLRNLVDRMLGSNKLP--NLAPTNIHEVLERVSSLVEAESQGS-ITLVRDYDPSIPDLLLDREQM 240
Cdd:COG5000 239 EDLERALDTIIRQVDRLKRIVDEFLDFARLPepQLEPVDLNELLREVLALYEPALKEKdIRLELDLDPDLPEVLADRDQL 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 241 IQAVLNMVRNAMQAIAGQndlrlGRITLRSRTLRQFTIghtrhrlvckVEIIDNGPGIPAELQETIFYPMVSGRPDGTGL 320
Cdd:COG5000 319 EQVLINLLKNAIEAIEEG-----GEIEVSTRREDGRVR----------IEVSDNGPGIPEEVLERIFEPFFTTKPKGTGL 383
|
330 340 350
....*....|....*....|....*....|....*....
gi 489186619 321 GLAIAQNIISQHQGLIECESHPGH-TVFSLFLPLEQGVH 358
Cdd:COG5000 384 GLAIVKKIVEEHGGTIELESRPGGgTTFTIRLPLAEEAE 422
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-352 |
7.29e-64 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 198.39 E-value: 7.29e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 240 MIQAVLNMVRNAMQAIAGqndlRLGRITLRSRTLRQFTIGHTRHRLVCKVEIIDNGPGIPAELQETIFYPMVSGRPDGTG 319
Cdd:cd16918 1 LIQVFLNLVRNAAQALAG----SGGEIILRTRTQRQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTG 76
|
90 100 110
....*....|....*....|....*....|...
gi 489186619 320 LGLAIAQNIISQHQGLIECESHPGHTVFSLFLP 352
Cdd:cd16918 77 LGLAIAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
3-356 |
2.24e-56 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 193.65 E-value: 2.24e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 3 TDTLHRLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTESPEALNSLRQAVEQAHPFTKREATLT 82
Cdd:PRK11360 260 TRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFPPNTPFASPLLDTLEHGTEHVDLEISFP 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 83 SITGvsiTVDYAVT--PILNRNETLLLLEVHPRDRLMRItREEAQLSKQE---TTKLLVRGLAHEIKNPLGGIRGAAQLL 157
Cdd:PRK11360 340 GRDR---TIELSVStsLLHNTHGEMIGALVIFSDLTERK-RLQRRVARQErlaALGELVAGVAHEIRNPLTAIRGYVQIW 415
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 158 SRELPEESLKDYTNVIIEEADRLRNLVDRML--GSNKLPNLAPTNIHEVLERVSSLV-EAESQGSITLVRDYDPSIPDLL 234
Cdd:PRK11360 416 RQQTSDPPSQEYLSVVLREVDRLNKVIDQLLefSRPRESQWQPVSLNALVEEVLQLFqTAGVQARVDFETELDNELPPIW 495
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 235 LDREQMIQAVLNMVRNAMQAIAGqndlrLGRITLRSRtlrQFTIGHtrhrlVCkVEIIDNGPGIPAELQETIFYPMVSGR 314
Cdd:PRK11360 496 ADPELLKQVLLNILINAVQAISA-----RGKIRIRTW---QYSDGQ-----VA-VSIEDNGCGIDPELLKKIFDPFFTTK 561
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 489186619 315 PDGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPLEQG 356
Cdd:PRK11360 562 AKGTGLGLALSQRIINAHGGDIEVESEPGVgTTFTLYLPINPQ 604
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
6-353 |
4.14e-54 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 181.92 E-value: 4.14e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 6 LHRLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTESPEALNSLRQAVEQAHPFTKREATLTSIT 85
Cdd:COG4191 7 LLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 86 GVSITVDYAVTPILNRNETLLLLEVHPRDRLMRITREEAQLSKQE----TTKL-----LVRGLAHEIKNPLGGIRGAAQL 156
Cdd:COG4191 87 LLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEqlvqSEKLaalgeLAAGIAHEINNPLAAILGNAEL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 157 LSRELPE----ESLKDYTNVIIEEADRLRNLVDRMLGSNKL--PNLAPTNIHEVLERVSSLVEAE-SQGSITLVRDYDPS 229
Cdd:COG4191 167 LRRRLEDepdpEELREALERILEGAERAAEIVRSLRAFSRRdeEEREPVDLNELIDEALELLRPRlKARGIEVELDLPPD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 230 IPDLLLDREQMIQAVLNMVRNAMQAIAGQNDlrlGRITLRSRTlrqftightRHRLVCkVEIIDNGPGIPAELQETIFYP 309
Cdd:COG4191 247 LPPVLGDPGQLEQVLLNLLINAIDAMEEGEG---GRITISTRR---------EGDYVV-ISVRDNGPGIPPEVLERIFEP 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 489186619 310 MVSGRP--DGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPL 353
Cdd:COG4191 314 FFTTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGGgTTFTITLPL 360
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
10-353 |
2.71e-49 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 169.20 E-value: 2.71e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 10 LLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQ-FISELFTESPEALNslrqaveQAHPFTKREATLTSITGVS 88
Cdd:COG5807 32 LFDSILEFVFFIDSKGEILECNDFAEDLYGLSQNEYIGKtFVEEKCILKDEQLY-------NKEAFDRIEISYLTKNGEF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 89 ITVDYavtPILNRNETLLLLEVHPRDRLMRITREEAQLSKQETTKL--LVRGLAHEIKNPLGGIRGAAQLLSRELPEESL 166
Cdd:COG5807 105 DEIIY---PIYYKDGVILGLITVYRDITKRKEAEDKLLRSEKLSVAgeLAAGIAHEIRNPLTSIKGFLQLLQESREDSER 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 167 KDYTNVIIEEADRLRNLVDRML--GSNKLPNLAPTNIHEVLERVSSLVEAE-SQGSITLVRDYDPSIPDLLLDREQMIQA 243
Cdd:COG5807 182 EEYFNIIISEIDRINTIITELLvlSKPKKFNFKKLNLNDVLEDVIALLSTEaILKNISIKYDLADDEPVINGDKNQLKQV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 244 VLNMVRNAMQAIAgqndlRLGRITLRSRTLRQFtightrhrlvCKVEIIDNGPGIPAELQETIFYPMVSGRPDGTGLGLA 323
Cdd:COG5807 262 FINLIKNAIEAME-----TGGNITIKTYVEGDF----------VVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLS 326
|
330 340 350
....*....|....*....|....*....|.
gi 489186619 324 IAQNIISQHQGLIECESHPGH-TVFSLFLPL 353
Cdd:COG5807 327 ICKKIIEEHNGTIEVESKPGKgTTFTIYLPL 357
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
7-355 |
8.79e-46 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 162.84 E-value: 8.79e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 7 HRLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTESP--EALNSLRQAVEQAHPFTKrEATLTSI 84
Cdd:COG5809 143 FRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDqeNVAAFISQLLKDGGIAQG-EVRFWTK 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 85 TGVSITVDYAVTPIlNRNETLLLLEVHPRDRLMRITREEaQLSKQETTKLLVR---GLAHEIKNPLGGIRGAAQLLSREL 161
Cdd:COG5809 222 DGRWRLLEASGAPI-KKNGEVDGIVIIFRDITERKKLEE-LLRKSEKLSVVGElaaGIAHEIRNPLTSLKGFIQLLKDTI 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 162 PEESlKDYTNVIIEEADRLRNLVDR--MLGSNKLPNLAPTNIHEVLERVSSLVEAES-QGSITLVRDYDPSIPDLLLDRE 238
Cdd:COG5809 300 DEEQ-KTYLDIMLSELDRIESIISEflVLAKPQAIKYEPKDLNTLIEEVIPLLQPQAlLKNVQIELELEDDIPDILGDEN 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 239 QMIQAVLNMVRNAMQAIAGQndlrlGRITLRsrtlrqftIGHTRHRLVcKVEIIDNGPGIPAELQETIFYPMVSGRPDGT 318
Cdd:COG5809 379 QLKQVFINLLKNAIEAMPEG-----GNITIE--------TKAEDDDKV-VISVTDEGCGIPEERLKKLGEPFYTTKEKGT 444
|
330 340 350
....*....|....*....|....*....|....*...
gi 489186619 319 GLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPLEQ 355
Cdd:COG5809 445 GLGLMVSYKIIEEHGGKITVESEVGKgTTFSITLPIKL 482
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
37-354 |
4.76e-45 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 157.38 E-value: 4.76e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 37 LLAVSGQRSHGQFISELFTESPEALNSLRQAVEQAHPFTKREATLTSITGVSITVDYAVTPILNRNETLLLLEVHPRDRL 116
Cdd:COG0642 14 LLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 117 MRITREEAQLSKQETTK-LLVRGLAHEIKNPLGGIRGAAQLLSRELPEEsLKDYTNVIIEEADRLRNLVDRMLGSNKL-- 193
Cdd:COG0642 94 LLLLALLLLLEEANEAKsRFLANVSHELRTPLTAIRGYLELLLEELDEE-QREYLETILRSADRLLRLINDLLDLSRLea 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 194 ----PNLAPTNIHEVLERVSSLVEAESQG-SITLVRDYDPSIPDLLLDREQMIQAVLNMVRNAMQAIAGQndlrlGRITL 268
Cdd:COG0642 173 gkleLEPEPVDLAELLEEVVELFRPLAEEkGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEG-----GTVTV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 269 RSRtlrqftightRHRLVCKVEIIDNGPGIPAELQETIFYPMVSGRPD----GTGLGLAIAQNIISQHQGLIECESHPGH 344
Cdd:COG0642 248 SVR----------REGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSrrggGTGLGLAIVKRIVELHGGTIEVESEPGK 317
|
330
....*....|.
gi 489186619 345 -TVFSLFLPLE 354
Cdd:COG0642 318 gTTFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
115-355 |
2.95e-43 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 149.67 E-value: 2.95e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 115 RLMRITREEAQLSKQETTklLVRGLAHEIKNPLGGIRGAAQLLSR--ELPEESLKDYTNVIIEEADRLRNLVDRMLGSNK 192
Cdd:COG2205 1 ELEEALEELEELERLKSE--FLANVSHELRTPLTSILGAAELLLDeeDLSPEERRELLEIIRESAERLLRLIEDLLDLSR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 193 L------PNLAPTNIHEVLERVSSLVEAESQGS-ITLVRDYDPSIPDLLLDREQMIQAVLNMVRNAMQAiAGQNdlrlGR 265
Cdd:COG2205 79 LesgklsLELEPVDLAELLEEAVEELRPLAEEKgIRLELDLPPELPLVYADPELLEQVLANLLDNAIKY-SPPG----GT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 266 ITLRSRTLRQFTIghtrhrlvckVEIIDNGPGIPAELQETIFYPMVSGRPD----GTGLGLAIAQNIISQHQGLIECESH 341
Cdd:COG2205 154 ITISARREGDGVR----------ISVSDNGPGIPEEELERIFERFYRGDNSrgegGTGLGLAIVKRIVEAHGGTIWVESE 223
|
250
....*....|....*
gi 489186619 342 PGH-TVFSLFLPLEQ 355
Cdd:COG2205 224 PGGgTTFTVTLPLAE 238
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
7-353 |
1.09e-40 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 149.50 E-value: 1.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 7 HRLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTES-PEALNSLRQAVEQAhpFTKREATLTSIT 85
Cdd:COG5805 159 LQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCdKEEFKERIESITEV--WQEFIIEREIIT 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 86 --GVSITVDYAVTPILNRNETLLLLEVHPRDrlmrITreeaqlSKQETTKLLVR------------GLAHEIKNPLGGIR 151
Cdd:COG5805 237 kdGRIRYFEAVIVPLIDTDGSVKGILVILRD----IT------EKKEAEELMARseklsiagqlaaGIAHEIRNPLTSIK 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 152 GAAQLLSRELpeESLKDYTNVIIEEADRLRNLVDRMLGSNK--LPNLAPTNIHEVLERVSSLVEAE-SQGSITLVRDYDP 228
Cdd:COG5805 307 GFLQLLQPGI--EDKEEYFDIMLSELDRIESIISEFLALAKpqAVNKEKENINELIQDVVTLLETEaILHNIQIRLELLD 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 229 SIPDLLLDREQMIQAVLNMVRNAMQAIAGQndlrlGRITLRSRTLRQFtightrhrlvCKVEIIDNGPGIPAELQETIFY 308
Cdd:COG5805 385 EDPFIYCDENQIKQVFINLIKNAIEAMPNG-----GTITIHTEEEDNS----------VIIRVIDEGIGIPEERLKKLGE 449
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 489186619 309 PMVSGRPDGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPL 353
Cdd:COG5805 450 PFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKgTTFTITLPL 495
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
8-355 |
2.50e-39 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 143.54 E-value: 2.50e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 8 RLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTESPEALNSLRQAVEQAHPFTKREATLTSITGV 87
Cdd:COG5002 40 LLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 88 SITVDYAVTPILNRNETLLLLEVHPRDRLMRITREEAQLSKQETTK-LLVRGLAHEIKNPLGGIRGAAQLLSRE--LPEE 164
Cdd:COG5002 120 LLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRrEFVANVSHELRTPLTSIRGYLELLLDGaaDDPE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 165 SLKDYTNVIIEEADRLRNLVDRML-------GSNKLpNLAPTNIHEVLERVSSLVEAES-QGSITLVRDYDPSIPDLLLD 236
Cdd:COG5002 200 ERREYLEIILEEAERLSRLVNDLLdlsrlesGELKL-EKEPVDLAELLEEVVEELRPLAeEKGIELELDLPEDPLLVLGD 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 237 REQMIQAVLNMVRNAMQAIAGQndlrlGRITLRSRTLRQFtightrhrlvCKVEIIDNGPGIPAELQETI---FY---PM 310
Cdd:COG5002 279 PDRLEQVLTNLLDNAIKYTPEG-----GTITVSLREEDDQ----------VRISVRDTGIGIPEEDLPRIferFYrvdKS 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 489186619 311 VSGRPDGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPLEQ 355
Cdd:COG5002 344 RSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKgTTFTITLPLAR 389
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
105-355 |
2.38e-33 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 128.71 E-value: 2.38e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 105 LLLLEVHPRDRLMRITREEAQLSKQETTKLLVRGLAHEIKNPLGGIRGAAQLLSRELPEESLKDYTNVIIEEADRLRNLV 184
Cdd:COG5808 214 LLQYNLLKRKTLLERVIQEINTQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKYFDIIQEEIQRINQIV 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 185 DR--MLGSNKLPNLAPTNIHEVLERVSSLVEAESQGS-ITLVR-DYDPSIPdLLLDREQMIQAVLNMVRNAMQAIAGQND 260
Cdd:COG5808 294 SEflVLGKPTAKKLELDDLNELIEEILSIIDSEANLKnIRVEKqSLDEPLH-IKCDKDRIKQVLLNLIKNAIEAMKEGGK 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 261 LRLgritlrsrtlrqfTIGHTRHRLVckVEIIDNGPGIPAELQETIFYPMVSGRPDGTGLGLAIAQNIISQHQGLIECES 340
Cdd:COG5808 373 LTI-------------SIENDDEKAV--IEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIES 437
|
250
....*....|....*.
gi 489186619 341 HPGH-TVFSLFLPLEQ 355
Cdd:COG5808 438 EEGKgTTFTIRLPLKK 453
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
135-353 |
4.59e-33 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 127.98 E-value: 4.59e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 135 LVRGLAHEIKNPLGGIRGAAQLLSRELPEES-LKDYTNVIIEEADRLRNLVDRMLGSNKlP---NLAPTNIHEVLERVSS 210
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKGLAKYFAERAPAGGeAHQLAQVMAKEADRLNRVVSELLELVK-PthlALQAVDLNDLINHSLQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 211 LVE--AESQGsITLVRDYDPSIPDLLLDREQMIQAVLNMVRNAMQAIAGQndlrlGRITLRSrtlrqftighTRHRLVCK 288
Cdd:PRK10364 319 LVSqdANSRE-IQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQH-----GVISVTA----------SESGAGVK 382
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489186619 289 VEIIDNGPGIPAELQETIFYPMVSGRPDGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPL 353
Cdd:PRK10364 383 ISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKgATFTLWLPV 448
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
130-357 |
8.62e-29 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 117.47 E-value: 8.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 130 ETTKLLVRGLAHEIKNPLGGIRGAAQL-LSRELPEESLKDYTNVIIEEADRLRNLVDRMLG-SNKLP-NLAPTNIHEVLE 206
Cdd:PRK13837 448 EAVGTLASGIAHNFNNILGAILGYAEMaLNKLARHSRAARYIDEIISAGARARLIIDQILAfGRKGErNTKPFDLSELVT 527
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 207 RVSSLVEAESQGSITLVRDYDPSIPDLLLDREQMIQAVLNMVRNAMQAI--AGQNDLRLGRITLRS-RTLRQFTIGHTRH 283
Cdd:PRK13837 528 EIAPLLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMdgAGRVDISLSRAKLRApKVLSHGVLPPGRY 607
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489186619 284 RLVCkVEiiDNGPGIPAELQETIFYPMVSGRPDGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPLEQGV 357
Cdd:PRK13837 608 VLLR-VS--DTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRgTRFDVYLPPSSKV 679
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
136-353 |
1.63e-25 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 106.85 E-value: 1.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 136 VRGLAHEIKNPLGGIRGAAQLLSRELPEESLKDYTNVIIEEADRLRNLVDRMLGSNKLPN------LAPTNIHEVLERVS 209
Cdd:PRK11100 260 VQTLTHELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQrqelevLEPVALAALLEELV 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 210 SLVEAE-SQGSITLVRDYDPSipDLLLDREQMIQAVLNMVRNAMqAIAGQNdlrlGRITLRSRTLRQFTightrhrlvcK 288
Cdd:PRK11100 340 EAREAQaAAKGITLRLRPDDA--RVLGDPFLLRQALGNLLDNAI-DFSPEG----GTITLSAEVDGEQV----------A 402
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489186619 289 VEIIDNGPGIPAELQETI---FYPMVsgRPDG----TGLGLAIAQNIISQHQGLIECESHPGHTVF-SLFLPL 353
Cdd:PRK11100 403 LSVEDQGPGIPDYALPRIferFYSLP--RPANgrksTGLGLAFVREVARLHGGEVTLRNRPEGGVLaTLTLPR 473
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
3-356 |
1.13e-24 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 104.87 E-value: 1.13e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 3 TDTLHRLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTESPEALNSLRQAVEQAHPFTKREATLT 82
Cdd:COG4251 143 LRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLG 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 83 SITGVSITVDYAVTPILNRNETLLLLEVHPRDRLMRITREEAQLSKQETTKLLVR----------GLAHEIKNPLGGIRG 152
Cdd:COG4251 223 GGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERsneeleqfayVASHDLREPLRKISG 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 153 AAQLLSRELPE---ESLKDYTNVIIEEADRLRNLVDRML-----GSNKLPnLAPTNIHEVLERV-SSLVEAESQGSITLV 223
Cdd:COG4251 303 FSQLLEEDYGDkldEEGREYLERIRDAAERMQALIDDLLaysrvGRQELE-FEPVDLNELLEEVlEDLEPRIEERGAEIE 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 224 RDYDPSIpdlLLDREQMIQAVLNMVRNAMQAIAGQndlRLGRITlrsrtlrqftIGHTRHRLVCKVEIIDNGPGIPAELQ 303
Cdd:COG4251 382 VGPLPTV---RGDPTLLRQVFQNLISNAIKYSRPG---EPPRIE----------IGAEREGGEWVFSVRDNGIGIDPEYA 445
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489186619 304 ETIFYPMV----SGRPDGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPLEQG 356
Cdd:COG4251 446 EKIFEIFQrlhsRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEgATFYFTLPKAPA 503
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
237-353 |
2.28e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 95.57 E-value: 2.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 237 REQMIQAVLNMVRNAMQAIAGQndlrlGRITLRSrtlrqftiGHTRHRLvcKVEIIDNGPGIPAELQETIFYPMVSGRP- 315
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGR-----GRITIRT--------WAHVDQV--LIEVEDTGSGIDPEILGRIFDPFFTTKPv 65
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 489186619 316 -DGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPL 353
Cdd:cd16943 66 gEGTGLGLSLSYRIIQKHGGTIRVASVPGGgTRFTIILPI 105
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
7-354 |
6.48e-24 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 101.46 E-value: 6.48e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 7 HRLLLDNLTTAVILLNGELRLEYMNPAAEMLLavsGQRSHGQFISELFtesPEALNSLRQAVEqahpftkreatltsITG 86
Cdd:COG3290 86 REAVLESIREGVIAVDRDGRITLINDAARRLL---GLDAIGRPIDEVL---AEVLETGERDEE--------------ILL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 87 VSITVDYAVTPILNRNETLLLLeVHPRDRLmRITREEAQLSKQETTKLLVRGLAHEIKNPLGGIRGAAQLLSrelpEESL 166
Cdd:COG3290 146 NGRVLVVNRVPIRDDGRVVGAV-ATFRDRT-ELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGE----YDEA 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 167 KDYtnvIIEEADRLRNLVDRMLGSNKLPNLAptnihEVLERVSSlvEAESQGsITLVRDYDPSIPDLLLDREQMIQAVLN 246
Cdd:COG3290 220 LEY---IDEISEELQELIDSLLSRIGNPVLA-----ALLLGKAA--RARERG-IDLTIDIDSDLPDLPLSDTDLVTILGN 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 247 MVRNAMQAIAGQNDLRlGRITLrsrtlrqfTIGHTRHRLVckVEIIDNGPGIPAELQETIFYPMVSGRP-DGTGLGLAIA 325
Cdd:COG3290 289 LLDNAIEAVEKLPEEE-RRVEL--------SIRDDGDELV--IEVEDSGPGIPEELLEKIFERGFSTKLgEGRGLGLALV 357
|
330 340 350
....*....|....*....|....*....|
gi 489186619 326 QNIISQHQGLIECESHPGH-TVFSLFLPLE 354
Cdd:COG3290 358 KQIVEKYGGTIEVESEEGEgTVFTVRLPKE 387
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
236-354 |
1.43e-23 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 93.87 E-value: 1.43e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 236 DREQMIQAVLNMVRNAMQAIAGQndlrlGRITLRSRtlrqftightRHRLVCKVEIIDNGPGIPAELQETIFYPMVSGRP 315
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEG-----GRITVTLE----------RDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK 66
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 489186619 316 D-----GTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPLE 354
Cdd:smart00387 67 RsrkigGTGLGLSIVKKLVELHGGEISVESEPGGgTTFTITLPLE 111
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
117-353 |
1.10e-21 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 95.32 E-value: 1.10e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 117 MRITREEAQLSKQETTKLLVRGLAHEIKNPLGGIRGAAQLL-SRELPEESLKDYTNVIIEEADRLRNLVDRMLGSNK--L 193
Cdd:COG5806 186 ILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLqEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKpqP 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 194 PNLAPTNIHEVLERVSSLVE--AESQGsITLVRDYDPSIpDLLLDREQMIQAVLNMVRNAMQAIagQNDlrlGRITLrsr 271
Cdd:COG5806 266 EKLEKIDVSEELEHVIDVLSpyANMNN-VEIQTELEPGL-YIEGDRQKLQQCLINIIKNGIEAM--PNG---GTLTI--- 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 272 tlrqfTIGHTRHRLVckVEIIDNGPGIPAELQETIFYPMVSGRPDGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLF 350
Cdd:COG5806 336 -----DVSIDKNKVI--ISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKgTTFTIT 408
|
...
gi 489186619 351 LPL 353
Cdd:COG5806 409 LPL 411
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
240-351 |
1.77e-19 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 82.27 E-value: 1.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 240 MIQAVLNMVRNAMQAIAGQndlrlGRITLRSRtlrqftigHTRHRLVckVEIIDNGPGIPAELQETIFYPMVSGRPD--- 316
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPG-----GTIEISLR--------QEGDGVV--LEVEDNGPGIPEEDLERIFERFYRGDKSreg 65
|
90 100 110
....*....|....*....|....*....|....*..
gi 489186619 317 -GTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFL 351
Cdd:cd00075 66 gGTGLGLAIVRRIVEAHGGRITVESEPGGgTTFTVTL 102
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
116-355 |
9.31e-19 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 86.89 E-value: 9.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 116 LMRITREEAQLSK-----QETTKLLVRGLAHEIKNPLGGIRGAAQLLSRElpEESLKDYTNVIIEEADRLRN-LVDRMLG 189
Cdd:PRK09467 208 VRSVTRAFNQMAAgikqlEDDRTLLMAGVSHDLRTPLTRIRLATEMMSEE--DGYLAESINKDIEECNAIIEqFIDYLRT 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 190 SNKLPnLAPTNIHEVLERVSSlVEAESQGSITLvrDYDPSIPDLLLDREQMIQAVLNMVRNAmqaiagqndLRLG--RIT 267
Cdd:PRK09467 286 GQEMP-MEMADLNALLGEVIA-AESGYEREIET--ALQPGPIEVPMNPIAIKRALANLVVNA---------ARYGngWIK 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 268 LRSrtlrqftiGHTRHRLVCKVEiiDNGPGIPAELQETIFYPMVSGrpD------GTGLGLAIAQNIISQHQGLIECESH 341
Cdd:PRK09467 353 VSS--------GTEGKRAWFQVE--DDGPGIPPEQLKHLFQPFTRG--DsargssGTGLGLAIVKRIVDQHNGKVELGNS 420
|
250
....*....|....*
gi 489186619 342 P-GHTVFSLFLPLEQ 355
Cdd:PRK09467 421 EeGGLSARAWLPLTT 435
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
236-355 |
8.13e-18 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 78.18 E-value: 8.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 236 DREQMIQAVLNMVRNAMQAIAGQNDlrlGRITLrsrtlrqftigHTRHRLVckVEIIDNGPGIPAELQETIFYPMVSGRP 315
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGE---ITVTL-----------SEGGELT--LTVEDNGIGIPPEDLPRIFEPFSTADK 65
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 489186619 316 D---GTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPLEQ 355
Cdd:pfam02518 66 RgggGTGLGLSIVRKLVELLGGTITVESEPGGgTTVTLTLPLAQ 109
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
236-343 |
1.79e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 74.50 E-value: 1.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 236 DREQMIQAVLNMVRNAMQAIAGQNDLRlGRITLRSRTLRQFTIghtrhrlvcKVEIIDNGPGIPAELQETIFYPMVSGRP 315
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRPSDV-GEVRIRVEADQDGRI---------VLIVCDNGKGFPREMRHRATEPYVTTRP 70
|
90 100
....*....|....*....|....*...
gi 489186619 316 DGTGLGLAIAQNIISQHQGLIECESHPG 343
Cdd:cd16944 71 KGTGLGLAIVKKIMEEHGGRISLSNREA 98
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
240-353 |
6.31e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 72.91 E-value: 6.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 240 MIQAVLNMVRNAmqaiagqndLRL---GRITLRSRTlrqftIGHTRHRLVCKVEIIDNGPGIPAELQETIFYPMV----- 311
Cdd:cd16922 1 LRQILLNLLGNA---------IKFteeGEVTLRVSL-----EEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSqadss 66
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 489186619 312 -SGRPDGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPL 353
Cdd:cd16922 67 tTRKYGGTGLGLAISKKLVELMGGDISVESEPGQgSTFTFTLPL 110
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
118-353 |
2.14e-15 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 77.64 E-value: 2.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 118 RITREEAQLSKQETTKLLVrGLAHEIKNPLGGIRGAAQLLSRELPEESLKDYTNVIIEEADRLRNLVDRML--------G 189
Cdd:PRK11466 431 RQARAEAEKASQAKSAFLA-AMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILdysaieagG 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 190 SNKLPNLAPTNIHEVLERVSSLVEAESQGS-ITLVRDYDPSIPDLLL-DREQMIQAVLNMVRNAMQAIagqndlRLGRIT 267
Cdd:PRK11466 510 KNVSVSDEPFEPRPLLESTLQLMSGRVKGRpIRLATDIADDLPTALMgDPRRIRQVITNLLSNALRFT------DEGSIV 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 268 LRSRTLRQFTIghtrhrlvckVEIIDNGPGIPAELQETIFYPMV--SGRPDGTGLGLAIAQNIISQHQGLIECESHPGH- 344
Cdd:PRK11466 584 LRSRTDGEQWL----------VEVEDSGCGIDPAKLAEIFQPFVqvSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVg 653
|
....*....
gi 489186619 345 TVFSLFLPL 353
Cdd:PRK11466 654 SCFCLRLPL 662
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
242-352 |
3.19e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 70.89 E-value: 3.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 242 QAVLNMVRNAMQAIAGQNDLRlgritlrsrtlRQFTIGHTR--HRLVcKVEIIDNGPGIPAELQETIFYPMVSGRPDGTG 319
Cdd:cd16920 3 QVLINLVRNGIEAMSEGGCER-----------RELTIRTSPadDRAV-TISVKDTGPGIAEEVAGQLFDPFYTTKSEGLG 70
|
90 100 110
....*....|....*....|....*....|....
gi 489186619 320 LGLAIAQNIISQHQGLIECESHP-GHTVFSLFLP 352
Cdd:cd16920 71 MGLSICRSIIEAHGGRLSVESPAgGGATFQFTLP 104
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
105-356 |
9.30e-15 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 74.60 E-value: 9.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 105 LLLLEvhprDRLMRITREEAQLSKQETTK-LLVRGLAHEIKNPLGGIRGAAQLL-------SRELPEESLKDYTNVI--- 173
Cdd:PRK09303 127 LLQLS----DELFVLRQENETLLEQLKFKdRVLAMLAHDLRTPLTAASLALETLelgqideDTELKPALIEQLQDQArrq 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 174 IEEADRL-RNLVDRMLGSNK----------LPNLAptniHEVLERVSSLVEAESQgsiTLVRDYDPSIPDLLLDREQMIQ 242
Cdd:PRK09303 203 LEEIERLiTDLLEVGRTRWEalrfnpqkldLGSLC----QEVILELEKRWLAKSL---EIQTDIPSDLPSVYADQERIRQ 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 243 AVLNMVRNAMQAIAGQndlrlGRITLrsrtlrqfTIghtRHRLVCKVE--IIDNGPGIPAELQETIFYPMV----SGRPD 316
Cdd:PRK09303 276 VLLNLLDNAIKYTPEG-----GTITL--------SM---LHRTTQKVQvsICDTGPGIPEEEQERIFEDRVrlprDEGTE 339
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 489186619 317 GTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPLEQG 356
Cdd:PRK09303 340 GYGIGLSVCRRIVRVHYGQIWVDSEPGQgSCFHFTLPVYRG 380
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-351 |
2.86e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 67.87 E-value: 2.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 240 MIQAVLNMVRNAMQAIAGQNDLRLgRITLRSRTLRQFtightrhrlvckVEIIDNGPGIPAELQETIFYPMVSGRP--DG 317
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENPRI-RIAARRLGGRLV------------LVVRDNGPGIAEEHLSRVFDPFFTTKPvgKG 67
|
90 100 110
....*....|....*....|....*....|....*
gi 489186619 318 TGLGLAIAQNIISQHQGLIECESH-PGHTVFSLFL 351
Cdd:cd16976 68 TGLGLSISYGIVEEHGGRLSVANEeGAGARFTFDL 102
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
135-188 |
4.09e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 63.77 E-value: 4.09e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 489186619 135 LVRGLAHEIKNPLGGIRGAAQLLSRELPEESLKDYTNVIIEEADRLRNLVDRML 188
Cdd:pfam00512 5 FLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLL 58
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
242-353 |
4.37e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 64.65 E-value: 4.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 242 QAVLNMVRNAmqaiagqndLRLGRITLR---SRTLRQFTIghtrhrlvckvEIIDNGPGIPAELQETIFYPMVsgRPD-- 316
Cdd:cd16949 3 RALENVLRNA---------LRYSPSKILldiSQDGDQWTI-----------TITDDGPGVPEDQLEQIFLPFY--RVDsa 60
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 489186619 317 ------GTGLGLAIAQNIISQHQGLIECE-SHPGHTVFSLFLPL 353
Cdd:cd16949 61 rdresgGTGLGLAIAERAIEQHGGKIKASnRKPGGLRVRIWLPA 104
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
242-352 |
1.82e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 63.55 E-value: 1.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 242 QAVLNMVRNAMQAIAgqndlRLGRITLRSRTLRQFTIGHTRH------RLVCkVEIIDNGPGIPAELQETIFYPMVSGRP 315
Cdd:cd16919 3 LAILNLAVNARDAMP-----EGGRLTIETSNQRVDADYALNYrdlipgNYVC-LEVSDTGSGMPAEVLRRAFEPFFTTKE 76
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 489186619 316 --DGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLP 352
Cdd:cd16919 77 vgKGTGLGLSMVYGFVKQSGGHLRIYSEPGVgTTVRIYLP 116
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
135-355 |
1.59e-11 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 65.34 E-value: 1.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 135 LVRGLAHEIKNPLGGIRGAAQLLSRELPEESlkdYTNVIIEEADRLrnlvDRMLgsNKLPNLAPTNIHEVLER----VSS 210
Cdd:PRK09470 246 LLSDISHELRTPLTRLQLATALLRRRQGESK---ELERIETEAQRL----DSMI--NDLLVLSRNQQKNHLERetfkANS 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 211 L---------VEAEsQGSITLVRDYDPSIPDLLLDREQMIQAVLNMVRNAmqaiagqndLRLG--RITLrsrtlrQFTIg 279
Cdd:PRK09470 317 LwsevledakFEAE-QMGKSLTVSAPPGPWPINGNPNALASALENIVRNA---------LRYShtKIEV------AFSV- 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 280 hTRHRLVCKVEiiDNGPGIPAELQETIFYPM--VSGRPD----GTGLGLAIAQNIISQHQGLIECE-SHPGHTVFSLFLP 352
Cdd:PRK09470 380 -DKDGLTITVD--DDGPGVPEEEREQIFRPFyrVDEARDresgGTGLGLAIVENAIQQHRGWVKAEdSPLGGLRLTIWLP 456
|
...
gi 489186619 353 LEQ 355
Cdd:PRK09470 457 LYK 459
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
119-353 |
1.87e-11 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 65.35 E-value: 1.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 119 IT-REEAQ-----LSKQETTklLVRGLAHEIKNPLGGIRGAAQ-LLSRELPEESLKdYTNVIIEEADRLRNL------VD 185
Cdd:PRK11091 266 ITeRKRYQdalekASRDKTT--FISTISHELRTPLNGIVGLSRiLLDTELTAEQRK-YLKTIHVSAITLGNIfndiidMD 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 186 RMlGSNKLP-NLAPTNIHEVLERVSSL--VEAESQGsITLVRDYDPSIPDL-LLDREQMIQAVLNMVRNAMQAIAGqndl 261
Cdd:PRK11091 343 KM-ERRKLQlDNQPIDFTDFLADLENLsgLQAEQKG-LRFDLEPLLPLPHKvITDGTRLRQILWNLISNAVKFTQQ---- 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 262 rlGRITLRSRTlrqftigHTRHRLVCKVEiiDNGPGIPAELQETIF--YPMVSGRPD-----GTGLGLAIAQNIISQHQG 334
Cdd:PRK11091 417 --GGVTVRVRY-------EEGDMLTFEVE--DSGIGIPEDELDKIFamYYQVKDSHGgkpatGTGIGLAVSKRLAQAMGG 485
|
250 260
....*....|....*....|
gi 489186619 335 LIECESHPGH-TVFSLFLPL 353
Cdd:PRK11091 486 DITVTSEEGKgSCFTLTIHA 505
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
110-354 |
3.40e-11 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 64.66 E-value: 3.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 110 VHPRDRLMRITREEA-QLSKQETTKLLVrgLAHEIKNPLGGIRGAAQLL--------SRELPEESLK--DYTNVIIEead 178
Cdd:PRK15347 377 VAERTQALAEAKQRAeQANKRKSEHLTT--ISHEIRTPLNGVLGALELLqntpltaeQMDLADTARQctLSLLAIIN--- 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 179 rlrNLVD--RMLGSNKLPNLAPTNIHEVLERVSSLVEAESQG-SITLVRDYDPSIP-DLLLDREQMIQAVLNMVRNAMQA 254
Cdd:PRK15347 452 ---NLLDfsRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSkSLTLRTFVGAHVPlYLHLDSLRLRQILVNLLGNAVKF 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 255 IAGqndlrlGRITLRsrtlrqftIGHTRHRLVCKVEiiDNGPGIPAELQETIFYPM--VSGRPDGTGLGLAIAQNIISQH 332
Cdd:PRK15347 529 TET------GGIRLR--------VKRHEQQLCFTVE--DTGCGIDIQQQQQIFTPFyqADTHSQGTGLGLTIASSLAKMM 592
|
250 260
....*....|....*....|...
gi 489186619 333 QGLIECESHPGH-TVFSLFLPLE 354
Cdd:PRK15347 593 GGELTLFSTPGVgSCFSLVLPLN 615
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
220-356 |
4.70e-11 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 63.78 E-value: 4.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 220 ITLVRDYDPSIPDLllDREQMIqAVL-----NMVRNAMQAIAGQNDlrlGRITLrsrtlrqfTIGHTRHRLVCkvEIIDN 294
Cdd:PRK11086 412 ITLIISEDSQLPDS--GDEDQV-HELitilgNLIENALEAVGGEEG---GEISV--------SLHYRNGWLHC--EVSDD 475
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489186619 295 GPGIPAELQETIFYPMVSGRPDGTGLGLAIAQNIISQHQGLIECESHPG-HTVFSLFLPLEQG 356
Cdd:PRK11086 476 GPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGvGTQFFVQIPWDGE 538
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
135-188 |
5.65e-11 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 57.61 E-value: 5.65e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 489186619 135 LVRGLAHEIKNPLGGIRGAAQLLSREL-PEESLKDYTNVIIEEADRLRNLVDRML 188
Cdd:cd00082 7 FLANVSHELRTPLTAIRGALELLEEELlDDEEQREYLERIREEAERLLRLINDLL 61
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
122-357 |
6.35e-11 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 63.54 E-value: 6.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 122 EEA--QLSKQETTKLLVRGLAHEIKNPLGGIRGAAQLLSRELPEESLKdyTNVIIEEADRLRNLVDR--MLgSNKLPNLA 197
Cdd:PRK13557 151 EDAlrQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDAD--RGRMARSVENIRAAAERaaTL-TQQLLAFA 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 198 --------PTNIHEVLERVSSLVEAESQGSITLVRDYDPSIPDLLLDREQMIQAVLNMVRNAMQAIAGQndlrlGRITLR 269
Cdd:PRK13557 228 rkqrlegrVLNLNGLVSGMGELAERTLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEG-----GRVTIR 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 270 SRTL------RQFTIGHTRHRLVCkVEIIDNGPGIPAELQETIFYPMVSGRPD--GTGLGLAIAQNIISQHQGLIECESH 341
Cdd:PRK13557 303 TRNVeiededLAMYHGLPPGRYVS-IAVTDTGSGMPPEILARVMDPFFTTKEEgkGTGLGLSMVYGFAKQSGGAVRIYSE 381
|
250
....*....|....*..
gi 489186619 342 PGH-TVFSLFLPLEQGV 357
Cdd:PRK13557 382 VGEgTTVRLYFPASDQA 398
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
135-188 |
6.73e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 57.19 E-value: 6.73e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 489186619 135 LVRGLAHEIKNPLGGIRGAAQLLSRELPEESLKDYTNVIIEEADRLRNLVDRML 188
Cdd:smart00388 5 FLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLL 58
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
141-354 |
6.75e-11 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 63.71 E-value: 6.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 141 HEIKNPLGGIRG-AAQLLSRELpEESLKDYTNVIIEEADRLRNLVDRMLGSNKL-------PNLaPTNIHEVLERVSSLV 212
Cdd:PRK11107 302 HELRTPLNGVIGfTRQTLKTPL-TPTQRDYLQTIERSANNLLAIINDILDFSKLeagklvlENI-PFSLRETLDEVVTLL 379
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 213 --EAESQGsITLVRDYDPSIPDLLL-DREQMIQAVLNMVRNAmqaI----AGQNDLRlgrITLRSrtlrqftigHTRHRL 285
Cdd:PRK11107 380 ahSAHEKG-LELTLNIDPDVPDNVIgDPLRLQQIITNLVGNA---IkfteSGNIDIL---VELRA---------LSNTKV 443
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489186619 286 VCKVEIIDNGPGIPAELQETIFYPM------VSGRPDGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLPLE 354
Cdd:PRK11107 444 QLEVQIRDTGIGISERQQSQLFQAFrqadasISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRgSTFWFHLPLD 519
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
246-352 |
1.04e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 58.07 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 246 NMVRNAMQAIAGQNDLRlGRITlrsrtlrqFTIGHTRHRLVCKVEiiDNGPGIPAELQETIFYPMVSGRPDGT-GLGLAI 324
Cdd:cd16915 7 NLIDNALDALAATGAPN-KQVE--------VFLRDEGDDLVIEVR--DTGPGIAPELRDKVFERGVSTKGQGErGIGLAL 75
|
90 100
....*....|....*....|....*....
gi 489186619 325 AQNIISQHQGLIECESHP-GHTVFSLFLP 352
Cdd:cd16915 76 VRQSVERLGGSITVESEPgGGTTFSIRIP 104
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-337 |
1.31e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 57.84 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 240 MIQAVLNMVRNAmqaiagqndLRLGRITLRSRTlrqftiGHTRHRLVCKVEiiDNGPGIPAELQETIFYPMVSGRP---- 315
Cdd:cd16950 1 LKRVLSNLVDNA---------LRYGGGWVEVSS------DGEGNRTRIQVL--DNGPGIAPEEVDELFQPFYRGDNargt 63
|
90 100
....*....|....*....|..
gi 489186619 316 DGTGLGLAIAQNIISQHQGLIE 337
Cdd:cd16950 64 SGTGLGLAIVQRISDAHGGSLT 85
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
141-352 |
1.92e-10 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 61.56 E-value: 1.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 141 HEIKNPLGGIRGAAQLLSRELPEESLKDYT-NVIIEEADRLRNLVDRMLGSNKLpNLAPTniHEVLERVS-----SLVEA 214
Cdd:PRK11006 213 HELRTPLTVLQGYLEMMQDQPLEGALREKAlHTMREQTQRMEGLVKQLLTLSKI-EAAPT--IDLNEKVDvpmmlRVLER 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 215 E----SQGSITLVRDYDPSIpDLLLDREQMIQAVLNMVRNAMqaiagqNDLRLG-RITLRSRtlrqftigHTRHRLVCKV 289
Cdd:PRK11006 290 EaqtlSQGKHTITFEVDNSL-KVFGNEDQLRSAISNLVYNAV------NHTPEGtHITVRWQ--------RVPQGAEFSV 354
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489186619 290 EiiDNGPGIPAE----LQETiFYPMVSGRP---DGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLP 352
Cdd:PRK11006 355 E--DNGPGIAPEhiprLTER-FYRVDKARSrqtGGSGLGLAIVKHALSHHDSRLEIESEVGKgTRFSFVLP 422
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-341 |
1.13e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 55.27 E-value: 1.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 240 MIQAVLNMVRNAMQAIAGQNdlrlGRITLRSrtlrqftiGHTRHRLVCKVEiiDNGPGIPAELQETIFYPMVSGRPDG-- 317
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDT----GRITVSA--------MPTGKMVTISVE--DEGPGIPQEKLESIFDRFYTERPANea 66
|
90 100
....*....|....*....|....*...
gi 489186619 318 ----TGLGLAIAQNIISQHQGLIECESH 341
Cdd:cd16953 67 fgqhSGLGLSISRQIIEAHGGISVAENH 94
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
133-353 |
1.20e-09 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 59.23 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 133 KLLVRGLAHEIKNPLGGIRGAAQLLSRELPEESL---KDYT--NVIIEEA---DRL-RNLVDRMLGSNKLPNLAPTNIHE 203
Cdd:PRK10604 213 KQLIDGIAHELRTPLVRLRYRLEMSDNLSAAESQalnRDIGqlEALIEELltyARLdRPQNELHLSEPDLPAWLSTHLAD 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 204 VlervsSLVEAESQGSITLVRDYDPSIPDL-LLDReqmiqAVLNMVRNAmqaiagqndLRLGRITLRSRTLRQftightr 282
Cdd:PRK10604 293 I-----QAVTPEKTVRLDTPHQGDYGALDMrLMER-----VLDNLLNNA---------LRYAHSRVRVSLLLD------- 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 283 HRLVCkVEIIDNGPGIPAELQETIFYPMVsgRPD--------GTGLGLAIAQNIISQHQGLIECESHP-GHTVFSLFLPL 353
Cdd:PRK10604 347 GNQAC-LIVEDDGPGIPPEERERVFEPFV--RLDpsrdratgGCGLGLAIVHSIALAMGGSVNCDESElGGARFSFSWPV 423
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-353 |
2.58e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 53.97 E-value: 2.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 240 MIQAVLNMVRNAmqaiagqndLRLGRITLRSRTLRQFTightrhRLVCKVEiiDNGPGIPAELQETIFYPMVSGRPD--- 316
Cdd:cd16939 1 MARALDNLLRNA---------LRYAHRTVRIALLVSGG------RLTLIVE--DDGPGIPAAARERVFEPFVRLDPSrdr 63
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 489186619 317 ---GTGLGLAIAQNIISQHQGLIECESHP-GHTVFSLFLPL 353
Cdd:cd16939 64 atgGFGLGLAIVHRVALWHGGHVECDDSElGGACFRLTWPR 104
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
293-352 |
2.73e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 53.87 E-value: 2.73e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489186619 293 DNGPGIPAELQETIF--YPMVSGRPD--GTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLP 352
Cdd:cd16921 41 DNGIGIDPEYAEKVFgiFQRLHSREEyeGTGVGLAIVRKIIERHGGRIWLESEPGEgTTFYFTLP 105
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
289-354 |
3.52e-09 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 58.51 E-value: 3.52e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489186619 289 VEIIDNGPGIPAELQETIFYPMVSGRPD----GTGLGLAIAQNIISQHQGLIECESHP-GHTVFSLFLPLE 354
Cdd:PRK10490 813 LDVWDNGPGIPPGQEQLIFDKFARGNKEsaipGVGLGLAICRAIVEVHGGTIWAENRPeGGACFRVTLPLE 883
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
121-336 |
9.47e-09 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 57.00 E-value: 9.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 121 REEAQLSKQETTKLLVRG-----LAHEIKNPLGGIRGAAQLLSRELPEESLKDYTNVIieeaDRLRNLVDRMLG------ 189
Cdd:COG4192 417 LRQTQDELIQAAKMAVVGqtmtsLAHELNQPLNAMSMYLFSAKKALEQENYAQLPTSL----DKIEGLIERMDKiikslr 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 190 --SNKLPN-LAPTNIHEVLERVSSLVEAES---QGSITLvrdydPSIPDLLLDREQMIQAVLNMVRNAMQAIAGQndlrl 263
Cdd:COG4192 493 qfSRKSDTpLQPVDLRQVIEQAWELVESRAkpqQITLHI-----PDDLMVQGDQVLLEQVLVNLLVNALDAVATQ----- 562
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489186619 264 gritlrsrtlRQFTIGHTRHRLVCKVEIIDNGPGIPaeLQETIFYPMVSGRPDGTGLGLAIAQNIISQHQGLI 336
Cdd:COG4192 563 ----------PQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDL 623
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
236-352 |
1.04e-08 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 52.49 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 236 DREQMIQAVLNMVRNAMQAIAGQndlrlGRITLRsrtLRQFTIGHtrhrlvCKVEIIDNGPGIPAELQETIFYPMVSGRP 315
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDG-----GRIRCI---LEKFRLNR------FLLTVSDSGPGIPPNLREEIFERFRQGDG 66
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 489186619 316 D------GTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLP 352
Cdd:cd16925 67 SstrahgGTGLGLSIVKEFVELHGGTVTVSDAPGGgALFQVELP 110
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
139-354 |
2.25e-08 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 55.90 E-value: 2.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 139 LAHEIKNPLGGIRGAAQLLSRE-LPEESLKDYTNVIIEEADRLRNLVDRMLGSNKLPN----LAPTNIHevlerVSSLVE 213
Cdd:PRK09959 719 MSHEIRTPISSIMGFLELLSGSgLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESgnyqLQPQWVD-----IPTLVQ 793
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 214 --AESQGSI----TLVRDYDPSIPDLLL---DREQMIQAVLNMVRNAMQAIAGqndlrlGRITLRSrTLRQFTIGHTrhr 284
Cdd:PRK09959 794 ntCHSFGAIaaskSIALSCSSTFPDHYLvkiDPQAFKQVLSNLLSNALKFTTE------GAVKITT-SLGHIDDNHA--- 863
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489186619 285 lVCKVEIIDNGPGIPAELQETIF--YPMVS-GRPD-GTGLGLAIAQNIISQHQGLIECESHPG-HTVFSLFLPLE 354
Cdd:PRK09959 864 -VIKMTIMDSGSGLSQEEQQQLFkrYSQTSaGRQQtGSGLGLMICKELIKNMQGDLSLESHPGiGTTFTITIPVE 937
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
3-355 |
1.43e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 49.90 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 3 TDTLHRLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTESPEALNSLRQAVEQAHPFTKREATLT 82
Cdd:COG3920 166 ELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRR 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 83 SITGVSITVDYAVTPILNRNETLLLLEVHPRDRLMRITREEAQLSKQETTKLLVRGLAHEIKNPLGGIRGAAQLLSRELP 162
Cdd:COG3920 246 RARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELLLRELHHRVKNNLQVVSSLLRLQARRAD 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 163 EESLKDYTNVIIeeaDRLR--NLVDRMLGSNKlpNLAPTNIHEVLER-VSSLVEAESQGSITLVRDydpsIPDLLLDREQ 239
Cdd:COG3920 326 DPEAREALEESQ---NRIQalALVHELLYQSE--DWEGVDLRDYLRElLEPLRDSYGGRGIRIELD----GPDVELPADA 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 240 MIQA--VLN-MVRNAMQ-AIAGQNDlrlGRITLRSRtlrqftightRHRLVCKVEIIDNGPGIPAELQEtifypmvsgrP 315
Cdd:COG3920 397 AVPLglILNeLVTNALKhAFLSGEG---GRIRVSWR----------REDGRLRLTVSDNGVGLPEDVDP----------P 453
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 489186619 316 DGTGLGLAIAQNIISQHQGLIECESHPGhTVFSLFLPLEQ 355
Cdd:COG3920 454 ARKGLGLRLIRALVRQLGGTLELDRPEG-TRVRITFPLAE 492
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
139-352 |
3.37e-06 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 48.61 E-value: 3.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 139 LAHEIKNPLGGIRGAAQL-LSRELPEESLKD--YTNviIEEADRLRNLVDRML-----GSNKL-PNLAPTNIHEVLERVS 209
Cdd:PRK09835 269 IAHEIRTPITNLITQTEIaLSQSRSQKELEDvlYSN--LEELTRMAKMVSDMLflaqaDNNQLiPEKKMLDLADEVGKVF 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 210 SLVEA-ESQGSITLVRDYDPsiPDLLLDREQMIQAVLNMVRNAMQAI-AGQndlrlgRITLRSRTLRQFtightrhrlvc 287
Cdd:PRK09835 347 DFFEAwAEERGVELRFVGDP--CQVAGDPLMLRRAISNLLSNALRYTpAGE------AITVRCQEVDHQ----------- 407
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489186619 288 kVEIIDNGPG--IPAELQETIF---Y---PMVSGRPDGTGLGLAIAQNIISQHQGLIECESHPGHTVFSLFLP 352
Cdd:PRK09835 408 -VQLVVENPGtpIAPEHLPRLFdrfYrvdPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLP 479
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
286-352 |
4.11e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 45.07 E-value: 4.11e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489186619 286 VCKVEIIDNGPGIPAELQETIFYPMVSG----RPDGTGLGLAIAQNIISQHQGLIECESHPGHTVFSLFLP 352
Cdd:cd16923 32 VVNIMFKNPSSHPLDFKLEKLFERFYRGdnsrNTEGAGLGLSIAKAIIELHGGSASAEYDDNHDLFKVRLP 102
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-343 |
9.18e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 44.32 E-value: 9.18e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 489186619 289 VEIIDNGPGIPAELQETI---FYPMVSGRPDGTGLGLAIAQNIISQHQGLIECESHPG 343
Cdd:cd16940 47 IRVEDNGPGIDEEELEALferFYRSDGQNYGGSGLGLSIVKRIVELHGGQIFLGNAQG 104
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
293-352 |
1.16e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 43.73 E-value: 1.16e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489186619 293 DNGPGIPAE----LQETiFYPMVSGR---PDGTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFLP 352
Cdd:cd16952 39 DTGPGIPPEhiprLTER-FYRVDIERcrnTGGTGLGLAIVKHVMSRHDARLLIASELGKgSRFTCLFP 105
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
141-354 |
1.26e-05 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 46.94 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 141 HEIKNPLGGIRG---AAQLLSRELPEESLkdytNVIIEEADRLRNLVDRM--LGSNKLPNLA----PTNIHEVLE-RVSS 210
Cdd:PRK10549 249 HELRTPLAVLRGeleAIQDGVRKFTPESV----ASLQAEVGTLTKLVDDLhqLSLSDEGALAyrktPVDLVPLLEvAGGA 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 211 LVEAESQGSITLVRDYDPSIPdLLLDREQMIQAVLNMVRNAMQAIAGQNDLRlgrITLRSRtlrqftigHTRHRLVckve 290
Cdd:PRK10549 325 FRERFASRGLTLQLSLPDSAT-VFGDPDRLMQLFNNLLENSLRYTDSGGSLH---ISAEQR--------DKTLRLT---- 388
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489186619 291 IIDNGPGIPAELQETI---FYPMVSGR---PDGTGLGLAIAQNIISQHQGLIECESHP-GHTVFSLFLPLE 354
Cdd:PRK10549 389 FADSAPGVSDEQLQKLferFYRTEGSRnraSGGSGLGLAICLNIVEAHNGRIIAAHSPfGGVSITVELPLE 459
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
10-133 |
1.71e-05 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 46.30 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 10 LLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTESPealnsLRQAVEQAHPFTKReatLTSITGVSI 89
Cdd:COG3829 16 ILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSP-----LLEVLKTGKPVTGV---IQKTGGKGK 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 489186619 90 TVDYAVTPILNRNETLLLLEV-HPRDRLMRITRE--EAQLSKQETTK 133
Cdd:COG3829 88 TVIVTAIPIFEDGEVIGAVETfRDITELKRLERKlrEEELERGLSAK 134
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
236-342 |
1.97e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 43.22 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 236 DREQMIQAVLNMVRNAMQAI-AGqndlrlGRITLRSRTLRQftightrhrlVCKVEIIDNGPGIPAELQETI---FYPMV 311
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTdTG------GKLRIRAAQTPQ----------EVRLDVEDSAPGVSDDQLARLferFYRVE 64
|
90 100 110
....*....|....*....|....*....|....
gi 489186619 312 SGR---PDGTGLGLAIAQNIISQHQGLIECESHP 342
Cdd:cd16946 65 SSRnraSGGSGLGLAICHNIALAHGGTISAEHSP 98
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-351 |
3.07e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 42.89 E-value: 3.07e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 289 VEIIDNGPGIPAELQETIF---YPMVSGRPD---GTGLGLAIAQNIISQHQGLIECESHPGH-TVFSLFL 351
Cdd:cd16947 55 IDIWDKGKGISETEKDHVFerlYTLEDSRNSakqGNGLGLTITKRLAESMGGSIYVNSKPYEkTVFTVTL 124
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
8-72 |
3.97e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 41.23 E-value: 3.97e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489186619 8 RLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFteSPEALNSLRQAVEQAH 72
Cdd:smart00091 4 RAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELI--HPEDRERVQEALQRLL 66
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
280-342 |
6.91e-05 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 44.62 E-value: 6.91e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489186619 280 HTRHRLVCKVEiiDNGPGIPAELQETIFypmVSG------RPdGTGLGLAIAQNIISQHQGLIECESHP 342
Cdd:PRK10815 404 QTDEHLHIVVE--DDGPGIPESKRELIF---DRGqradtlRP-GQGLGLSVAREITEQYEGKISAGDSP 466
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
219-342 |
8.82e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 41.85 E-value: 8.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 219 SITLVRDYDPSIpDLLLDREQMIQAVLNMVRNAMQaiagqndLRLGRITLrsrTLRQftighTRHRLVCKVEiiDNGPGI 298
Cdd:cd16954 18 GVSISLDISPEL-RFPGERNDLMELLGNLLDNACK-------WCLEFVEV---TARQ-----TDGGLHLIVD--DDGPGV 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 489186619 299 PAELQETIFypmVSG-RPD----GTGLGLAIAQNIISQHQGLIECESHP 342
Cdd:cd16954 80 PESQRSKIF---QRGqRLDeqrpGQGLGLAIAKEIVEQYGGELSLSDSP 125
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
293-353 |
9.92e-05 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 44.19 E-value: 9.92e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489186619 293 DNGPGIPAELQETIFYPM------VSGRPDGTGLGLAIAQNIISQHQGLIECESHPG-HTVFSLFLPL 353
Cdd:PRK10841 600 DTGVGIPAKEVVRLFDPFfqvgtgVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGmGSQFTIRIPL 667
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
8-106 |
2.05e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 40.48 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 8 RLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTE--SPEALNSLRQAVEQAHPFTKREATLTSIT 85
Cdd:pfam00989 4 RAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEedDAEVAELLRQALLQGEESRGFEVSFRVPD 83
|
90 100
....*....|....*....|.
gi 489186619 86 GVSITVDYAVTPILNRNETLL 106
Cdd:pfam00989 84 GRPRHVEVRASPVRDAGGEIL 104
|
|
| PRK11388 |
PRK11388 |
DNA-binding transcriptional regulator DhaR; Provisional |
7-128 |
2.28e-04 |
|
DNA-binding transcriptional regulator DhaR; Provisional
Pssm-ID: 183114 [Multi-domain] Cd Length: 638 Bit Score: 43.13 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 7 HRLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTESPealnSLRQAVEQAHPFTKREATLTSiTG 86
Cdd:PRK11388 205 LNALLESMDDGVIAWDEQGNLQFLNAQAARLLRLDATASQGRAITELLTLPA----VLQQAIKQAHPLKHVEVTFES-QG 279
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 489186619 87 VSITVDYAVTPILNRNETLLLLEVHPRDRLMRITREeaQLSK 128
Cdd:PRK11388 280 QFIDAVITLKPIIEGQGTSFILLLHPVEQMRQLMTS--QLGK 319
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
289-352 |
2.62e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 42.90 E-value: 2.62e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489186619 289 VEIIDNGPGIPAELQETIFYPMVSGR---PDGTGLGLAIAQNIISQHQGLIECESH-PGHTVFSLFLP 352
Cdd:PRK15053 471 IEVADQGCGVPESLRDKIFEQGVSTRadePGEHGIGLYLIASYVTRCGGVITLEDNdPCGTLFSIFIP 538
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
232-353 |
4.62e-04 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 42.09 E-value: 4.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 232 DLLLDR---EQMIQAVLNMVRNAM----------QAiAGQNdlRLGRITLRSRtlrqftigHTRHRLVckVEIIDNGPGI 298
Cdd:COG0643 267 ETELDRtvlERLGDPLVHLVRNAVdhgietpeerLA-AGKP--ETGTITLSAY--------HEGGRVV--IEVSDDGRGL 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 299 ------------------------PAELQETIFYP---------MVSGRpdgtGLGLAIAQNIISQHQGLIECESHPGH- 344
Cdd:COG0643 334 dlekirakaiekglitaeeaaalsDEELLELIFAPgfstaeevtDLSGR----GVGMDVVKTNIEALGGTIEIESEPGKg 409
|
....*....
gi 489186619 345 TVFSLFLPL 353
Cdd:COG0643 410 TTFTLRLPL 418
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
264-352 |
5.80e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 38.81 E-value: 5.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 264 GRITLRSRTLRQFTIghtrhrlvckVEIIDNGPGIPAELQETIFYPMVSG---RPDG--TGLGLAIAQNIISQ--HQglI 336
Cdd:cd16948 25 GKIEIYSETNEQGVV----------LSIKDFGIGIPEEDLPRVFDKGFTGengRNFQesTGMGLYLVKKLCDKlgHK--I 92
|
90
....*....|....*..
gi 489186619 337 ECESHPGH-TVFSLFLP 352
Cdd:cd16948 93 DVESEVGEgTTFTITFP 109
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
289-356 |
9.94e-04 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 40.77 E-value: 9.94e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489186619 289 VEIIDNGPGIPAELQETIFYPMvSGRPDGTGLGLAIAQNIISQHQG---LIECESHPGH-TVFSLFLPLEQG 356
Cdd:COG2972 375 ITVEDNGVGMPEEKLEKLLEEL-SSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEgTTVTIRIPLEEE 445
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
8-110 |
1.64e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 39.62 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 8 RLLLDNLTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFTES--PEALNSLRQAVEQAHPFTKREATLTSIT 85
Cdd:COG2202 140 RLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEdrERLLELLRRLLEGGRESYELELRLKDGD 219
|
90 100
....*....|....*....|....*
gi 489186619 86 GVSITVDYAVTPILNRNETLLLLEV 110
Cdd:COG2202 220 GRWVWVEASAVPLRDGGEVIGVLGI 244
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
291-351 |
2.43e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 37.05 E-value: 2.43e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489186619 291 IIDNGPGIPAELQETIFYPMVS-GRPDG----TGLGLAIAQNIISQHQGLIECESHPGHTVFSLFL 351
Cdd:cd16945 41 VFDEGSGIPDYALNRVFERFYSlPRPHSgqksTGLGLAFVQEVAQLHGGRITLRNRPDGVLAFLTL 106
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
14-114 |
2.72e-03 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 36.84 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 14 LTTAVILLNGELRLEYMNPAAEMLLAVSGQRSHGQFISELFteSPEALNSLRQAVEQA---HPFTKREATLTSITGVSIT 90
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLI--HPEDREELRERLENLlsgGEPVTLEVRLRRKDGSVIW 78
|
90 100
....*....|....*....|....
gi 489186619 91 VDYAVTPILNRNETLLLLEVHPRD 114
Cdd:cd00130 79 VLVSLTPIRDEGGEVIGLLGVVRD 102
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
140-343 |
4.37e-03 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 38.86 E-value: 4.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 140 AHEIKNPLGGIRGAAQL--LSRELPEESLKDYTNVI--IEEADRLrnlVDRMLGSNKLPNL------APTNIHEVLER-V 208
Cdd:PRK10337 245 AHELRSPLAALKVQTEVaqLSDDDPQARKKALLQLHagIDRATRL---VDQLLTLSRLDSLdnlqdvAEIPLEDLLQSaV 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489186619 209 SSLVEAESQGSITLVRDydpsIPDLLLDREqmIQAVL--NMVRNAM-QAIAGQNDLRLGRITLRSRTLRqftightrhrl 285
Cdd:PRK10337 322 MDIYHTAQQAGIDVRLT----LNAHPVIRT--GQPLLlsLLVRNLLdNAIRYSPQGSVVDVTLNARNFT----------- 384
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489186619 286 vckveIIDNGPGIPAELQETI---FYpmvsgRP-----DGTGLGLAIAQNIISQHQGLIECESHPG 343
Cdd:PRK10337 385 -----VRDNGPGVTPEALARIgerFY-----RPpgqeaTGSGLGLSIVRRIAKLHGMNVSFGNAPE 440
|
|
| |
