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Conserved domains on  [gi|489188158|ref|WP_003097554|]
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MULTISPECIES: AraC family transcriptional regulator [Pseudomonas]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 11677366)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  33837749|12596232|10473770|15808743|9409145|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
246-327 1.24e-17

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 76.44  E-value: 1.24e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158   246 PSIAWVARQLKVTERTLRRRLADE-GTNYREVLDLVRHDRARQLLRDERLRIEEVAERLGYMDTSSFRHAFRRWTGQCAN 324
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 489188158   325 DYR 327
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
132-332 3.74e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.82  E-value: 3.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 132 RLYHANVLASAAYAVFRDLLLGELELVRLRLPERNGDVRAYEEYFRVPVYFAGAGITFTLPEELLEAEIATANSAVFQAS 211
Cdd:COG2207   55 GGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRAL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 212 LALGSKAFNTRVTREMGGYRQRIVALLEVLQDRYPSIAWVARQLKVTERTLRRRLADE-GTNYREVLDLVRHDRARQLLR 290
Cdd:COG2207  135 ELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLA 214

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 489188158 291 DERLRIEEVAERLGYMDTSSFRHAFRRWTGQCANDYRQARLA 332
Cdd:COG2207  215 ETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRA 256
Arabinose_bd super family cl14988
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 59-198 1.53e-09

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


The actual alignment was detected with superfamily member pfam12625:

Pssm-ID: 432679  Cd Length: 185  Bit Score: 56.50  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158   59 GLSLGEHYRLSDYGVAGLALQSAGTVGEALQLIKTNMLLFrKDIRGIAVRRSSCDTVDVDIDLQDKPdwpqsARLYHANV 138
Cdd:pfam12625  47 GLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLLRYLRLL-SDALELRLEEGEGGLARLRLDVRPIP-----GRRRDFLL 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489188158  139 LASAAYAV--FRDLLLGELELVRLRLP-ERNGDVRAYEEYFRVPVYFAGAGITFTLPEELLEA 198
Cdd:pfam12625 121 ELALAALLrlARWLLGRRLPPLRVEFPhPAPADAAEYERLFGCPVRFGAPRNALVFDAADLDR 183
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
246-327 1.24e-17

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 76.44  E-value: 1.24e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158   246 PSIAWVARQLKVTERTLRRRLADE-GTNYREVLDLVRHDRARQLLRDERLRIEEVAERLGYMDTSSFRHAFRRWTGQCAN 324
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 489188158   325 DYR 327
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
132-332 3.74e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.82  E-value: 3.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 132 RLYHANVLASAAYAVFRDLLLGELELVRLRLPERNGDVRAYEEYFRVPVYFAGAGITFTLPEELLEAEIATANSAVFQAS 211
Cdd:COG2207   55 GGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRAL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 212 LALGSKAFNTRVTREMGGYRQRIVALLEVLQDRYPSIAWVARQLKVTERTLRRRLADE-GTNYREVLDLVRHDRARQLLR 290
Cdd:COG2207  135 ELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLA 214

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 489188158 291 DERLRIEEVAERLGYMDTSSFRHAFRRWTGQCANDYRQARLA 332
Cdd:COG2207  215 ETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRA 256
HTH_18 pfam12833
Helix-turn-helix domain;
251-329 9.70e-16

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 71.08  E-value: 9.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158  251 VARQLKVTERTLRRRLADE-GTNYREVLDLVRHDRARQLLRDE-RLRIEEVAERLGYMDTSSFRHAFRRWTGQCANDYRQ 328
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 489188158  329 A 329
Cdd:pfam12833  81 R 81
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 233-332 1.09e-13

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 70.57  E-value: 1.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 233 RIVALLEVLQDRY---PSIAWVARQLKVTERTLRRRLADE-GTNYREVLDLVRHDRARQLLRDERLRIEEVAERLGYMDT 308
Cdd:COG4977  211 RLARAQAWMEANLeepLSVDELARRAGMSPRTLERRFRAAtGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSA 290

                         90       100
                 ....*....|....*....|....
gi 489188158 309 SSFRHAFRRWTGQCANDYRQARLA 332
Cdd:COG4977  291 SHFRRAFRRRFGVSPSAYRRRFRA 314
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 59-198 1.53e-09

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 56.50  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158   59 GLSLGEHYRLSDYGVAGLALQSAGTVGEALQLIKTNMLLFrKDIRGIAVRRSSCDTVDVDIDLQDKPdwpqsARLYHANV 138
Cdd:pfam12625  47 GLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLLRYLRLL-SDALELRLEEGEGGLARLRLDVRPIP-----GRRRDFLL 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489188158  139 LASAAYAV--FRDLLLGELELVRLRLP-ERNGDVRAYEEYFRVPVYFAGAGITFTLPEELLEA 198
Cdd:pfam12625 121 ELALAALLrlARWLLGRRLPPLRVEFPhPAPADAAEYERLFGCPVRFGAPRNALVFDAADLDR 183
ftrA PRK09393
transcriptional activator FtrA; Provisional
 231-327 2.72e-08

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 54.58  E-value: 2.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 231 RQRIVALLEVLQDRYP---SIAWVARQLKVTERTLRRRLAD-EGTNYREVLDLVRHDRARQLLRDERLRIEEVAERLGYM 306
Cdd:PRK09393 217 SDRLGPLIDWMRAHLAephTVASLAARAAMSPRTFLRRFEAaTGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFG 296

                         90       100
                 ....*....|....*....|.
gi 489188158 307 DTSSFRHAFRRWTGQCANDYR 327
Cdd:PRK09393 297 SEESLRHHFRRRAATSPAAYR 317
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
246-327 1.24e-17

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 76.44  E-value: 1.24e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158   246 PSIAWVARQLKVTERTLRRRLADE-GTNYREVLDLVRHDRARQLLRDERLRIEEVAERLGYMDTSSFRHAFRRWTGQCAN 324
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 489188158   325 DYR 327
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
132-332 3.74e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.82  E-value: 3.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 132 RLYHANVLASAAYAVFRDLLLGELELVRLRLPERNGDVRAYEEYFRVPVYFAGAGITFTLPEELLEAEIATANSAVFQAS 211
Cdd:COG2207   55 GGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRAL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 212 LALGSKAFNTRVTREMGGYRQRIVALLEVLQDRYPSIAWVARQLKVTERTLRRRLADE-GTNYREVLDLVRHDRARQLLR 290
Cdd:COG2207  135 ELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLA 214

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 489188158 291 DERLRIEEVAERLGYMDTSSFRHAFRRWTGQCANDYRQARLA 332
Cdd:COG2207  215 ETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRA 256
HTH_18 pfam12833
Helix-turn-helix domain;
251-329 9.70e-16

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 71.08  E-value: 9.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158  251 VARQLKVTERTLRRRLADE-GTNYREVLDLVRHDRARQLLRDE-RLRIEEVAERLGYMDTSSFRHAFRRWTGQCANDYRQ 328
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRElGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 489188158  329 A 329
Cdd:pfam12833  81 R 81
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 233-332 1.09e-13

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 70.57  E-value: 1.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 233 RIVALLEVLQDRY---PSIAWVARQLKVTERTLRRRLADE-GTNYREVLDLVRHDRARQLLRDERLRIEEVAERLGYMDT 308
Cdd:COG4977  211 RLARAQAWMEANLeepLSVDELARRAGMSPRTLERRFRAAtGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSA 290

                         90       100
                 ....*....|....*....|....
gi 489188158 309 SSFRHAFRRWTGQCANDYRQARLA 332
Cdd:COG4977  291 SHFRRAFRRRFGVSPSAYRRRFRA 314
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 59-198 1.53e-09

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 56.50  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158   59 GLSLGEHYRLSDYGVAGLALQSAGTVGEALQLIKTNMLLFrKDIRGIAVRRSSCDTVDVDIDLQDKPdwpqsARLYHANV 138
Cdd:pfam12625  47 GLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLLRYLRLL-SDALELRLEEGEGGLARLRLDVRPIP-----GRRRDFLL 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489188158  139 LASAAYAV--FRDLLLGELELVRLRLP-ERNGDVRAYEEYFRVPVYFAGAGITFTLPEELLEA 198
Cdd:pfam12625 121 ELALAALLrlARWLLGRRLPPLRVEFPhPAPADAAEYERLFGCPVRFGAPRNALVFDAADLDR 183
ftrA PRK09393
transcriptional activator FtrA; Provisional
 231-327 2.72e-08

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 54.58  E-value: 2.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 231 RQRIVALLEVLQDRYP---SIAWVARQLKVTERTLRRRLAD-EGTNYREVLDLVRHDRARQLLRDERLRIEEVAERLGYM 306
Cdd:PRK09393 217 SDRLGPLIDWMRAHLAephTVASLAARAAMSPRTFLRRFEAaTGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFG 296

                         90       100
                 ....*....|....*....|.
gi 489188158 307 DTSSFRHAFRRWTGQCANDYR 327
Cdd:PRK09393 297 SEESLRHHFRRRAATSPAAYR 317
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 247-330 4.89e-07

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 50.31  E-value: 4.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 247 SIAWVARQLKVTERTLRRRLADEGTNYREVLDLVRHDRARQLLRDERLRIEEVAERLGYMDTSSFRHAFRRWTGQCANDY 326
Cdd:PRK09978 160 TLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEY 239


                 ....
gi 489188158 327 RQAR 330
Cdd:PRK09978 240 QERS 243
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
200-332 8.03e-07

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 49.68  E-value: 8.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 200 IATANSAVFQASLALGSKAFNTrvtremGGYRQ--RIVALLEVLQDRYP-SIAW--VARQLKVTERTLRRRLADE-GTNY 273
Cdd:PRK13503 143 IASREILFMQLLVLLRKSSLQE------NGENSdaRLNQLLAWLEDHFAeEVNWeaLADQFSLSLRTLHRQLKQQtGLTP 216

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489188158 274 REVLDLVRHDRARQLLRDERLRIEEVAERLGYMDTSSFRHAFRRWTGQCANDYRQARLA 332
Cdd:PRK13503 217 QRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRDIRQGRDG 275
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 232-338 2.34e-06

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 48.90  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 232 QRIVALLEVLQDRYPSIAWVARQLKVTERTLRRRLADE-GTNYREVLDLVRHDRARQLLrDERLRIEEVAERLGYMDTSS 310
Cdd:COG2169   87 ARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHtGVTPKAYARARRLLRARQLL-QTGLSVTDAAYAAGFGSLSR 165

                         90       100
                 ....*....|....*....|....*...
gi 489188158 311 FRHAFRRWTGQCANDYRQARlAGKTARR 338
Cdd:COG2169  166 FYEAFKKLLGMTPSAYRRGG-AGAAIRF 192
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 231-318 3.48e-06

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 48.07  E-value: 3.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 231 RQRIVALLEVLQDRYPSIAWVARQLKVTERTLRRRLADEGTNYREVLDLVRHDRARQLLRDERLRIEEVAERLGYMDTSS 310
Cdd:PRK15185 208 KERVYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSY 287


                 ....*...
gi 489188158 311 FRHAFRRW 318
Cdd:PRK15185 288 FIQCFKKY 295
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 255-327 4.22e-05

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 44.31  E-value: 4.22e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489188158 255 LKVTERTLRRRLADEGTNYREVLDLVRHDRARQLLRDERlRIEEVAERLGYMDTSSFRHAFRRWTG----QCANDYR 327
Cdd:PRK09940 160 LYISESLLKKKLKQEQTTFSQILLDARMQHAKNLIRVEG-SVNKIAEQCGYASTSYFIYAFRKHFGnspkRVSKEYR 235
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 206-328 1.13e-04

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 43.48  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 206 AVFQASLALGSKAFNTRVT---REMGGYRQRIVALLEVLQDRYPSIAWVARQLKVTERTLRRRLADEGTNYREVLDLVRH 282
Cdd:PRK09685 172 ALLEALIALLRPALHQRESvqpRRERQFQKVVALIDQSIQEEILRPEWIAGELGISVRSLYRLFAEQGLVVAQYIRNRRL 251

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489188158 283 DRARQLLRD--ERLRIEEVAERLGYMDTSSFRHAFRRWTGQCANDYRQ 328
Cdd:PRK09685 252 DRCADDLRPaaDDEKITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYRR 299
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
244-328 1.89e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 42.58  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188158 244 RYPSIAWVARQLKVTERTLRRRLADE-GTNYREVLDLVRHDRARQLLRDERLRIEEVAERLGYMDTSSFRHAFRRWTGQC 322
Cdd:PRK13501 191 AYFDMADFCHKNQLVERSLKQLFRQQtGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMT 270


                 ....*.
gi 489188158 323 ANDYRQ 328
Cdd:PRK13501 271 PRDYRQ 276
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 251-317 6.39e-04

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 40.82  E-value: 6.39e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489188158 251 VARQLKVTERTLRRRLADEGTNYREVLDLVRHDRARQLLRDERLRIEEVAERLGYMDTSSFRHAFRR 317
Cdd:PRK15186 203 ISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKK 269
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
253-328 8.88e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 40.42  E-value: 8.88e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489188158 253 RQLKVTERTLRRRL-ADEGTNYREVLDLVRHDRARQLLRDERLRIEEVAERLGYMDTSSFRHAFRRWTGQCANDYRQ 328
Cdd:PRK13502 200 QQEQCSERVLRQQFrAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWRH 276
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 291-328 3.04e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 35.21  E-value: 3.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 489188158  291 DERLRIEEVAERLGYmDTSSFRHAFRRWTGQCANDYRQ 328
Cdd:pfam00165   6 STNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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