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Conserved domains on  [gi|489188292|ref|WP_003097687|]
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class I SAM-dependent methyltransferase [Pseudomonas aeruginosa]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 57-168 1.29e-21

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 87.74  E-value: 1.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  57 WLGDVRGREILCLASAGGQQAPILAAAGARVTLFDASAGQLDKDRQVAARDRLELACVQGDMRDLStFADASFDLVFNPI 136
Cdd:COG2226   17 ALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLP-FPDGSFDLVISSF 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489188292 137 SNLYVDDVLPVWRECARVLRPGGKLLASFYNP 168
Cdd:COG2226   96 VLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 57-168 1.29e-21

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 87.74  E-value: 1.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  57 WLGDVRGREILCLASAGGQQAPILAAAGARVTLFDASAGQLDKDRQVAARDRLELACVQGDMRDLStFADASFDLVFNPI 136
Cdd:COG2226   17 ALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLP-FPDGSFDLVISSF 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489188292 137 SNLYVDDVLPVWRECARVLRPGGKLLASFYNP 168
Cdd:COG2226   96 VLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 67-162 1.07e-19

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 81.17  E-value: 1.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292   67 LCLASAGGQQAPILAAAGARVTLFDASAGQLDKDRQVAARDRLELacVQGDMRDLStFADASFDLVFNPISNLYVDDVLP 146
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTF--VVGDAEDLP-FPDNSFDLVLSSEVLHHVEDPER 77

                          90
                  ....*....|....*.
gi 489188292  147 VWRECARVLRPGGKLL 162
Cdd:pfam08241  78 ALREIARVLKPGGILI 93
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 66-166 5.78e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.91  E-value: 5.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  66 ILCL-ASAGGQQAPILAAAGARVTLFDASAGQLDKDRQVAAR---DRLELacVQGDMRDLSTFADASFDLVF-NPISNLY 140
Cdd:cd02440    2 VLDLgCGTGALALALASGPGARVTGVDISPVALELARKAAAAllaDNVEV--LKGDAEELPPEADESFDVIIsDPPLHHL 79

                         90       100
                 ....*....|....*....|....*.
gi 489188292 141 VDDVLPVWRECARVLRPGGKLLASFY 166
Cdd:cd02440   80 VEDLARFLEEARRLLKPGGVLVLTLV 105
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 82-161 2.75e-07

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 50.53  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  82 AAGARVTLFDASAGQLDKDRQVAARDRLelacVQGDMRDLsTFADASFDLVFnpiSNLYV---DDVLPVWRECARVLRPG 158
Cdd:PRK10258  62 ERGSQVTALDLSPPMLAQARQKDAADHY----LAGDIESL-PLATATFDLAW---SNLAVqwcGNLSTALRELYRVVRPG 133


                 ...
gi 489188292 159 GKL 161
Cdd:PRK10258 134 GVV 136
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 57-162 2.73e-06

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 47.26  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292   57 WLGDVRGREILCLASAGGQQAPILA---AAGARVTLFDASAGQLDKDRQVAARDrLELACVQGDMRDLStFADASFDLV- 132
Cdd:TIGR01934  34 LIGVFKGQKVLDVACGTGDLAIELAksaPDRGKVTGVDFSSEMLEVAKKKSELP-LNIEFIQADAEALP-FEDNSFDAVt 111

                          90       100       110
                  ....*....|....*....|....*....|..
gi 489188292  133 --FNpISNlyVDDVLPVWRECARVLRPGGKLL 162
Cdd:TIGR01934 112 iaFG-LRN--VTDIQKALREMYRVLKPGGRLV 140
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 57-168 1.29e-21

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 87.74  E-value: 1.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  57 WLGDVRGREILCLASAGGQQAPILAAAGARVTLFDASAGQLDKDRQVAARDRLELACVQGDMRDLStFADASFDLVFNPI 136
Cdd:COG2226   17 ALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLP-FPDGSFDLVISSF 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489188292 137 SNLYVDDVLPVWRECARVLRPGGKLLASFYNP 168
Cdd:COG2226   96 VLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 67-162 1.07e-19

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 81.17  E-value: 1.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292   67 LCLASAGGQQAPILAAAGARVTLFDASAGQLDKDRQVAARDRLELacVQGDMRDLStFADASFDLVFNPISNLYVDDVLP 146
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTF--VVGDAEDLP-FPDNSFDLVLSSEVLHHVEDPER 77

                          90
                  ....*....|....*.
gi 489188292  147 VWRECARVLRPGGKLL 162
Cdd:pfam08241  78 ALREIARVLKPGGILI 93
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 62-167 3.05e-18

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 78.52  E-value: 3.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  62 RGREILCLASAGGQQAPILAAAGARVTLFDASAGQLDKDRQVAARDRLELacVQGDMRDLStFADASFDLVFNPISNLYV 141
Cdd:COG2227   24 AGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNVDF--VQGDLEDLP-LEDGSFDLVICSEVLEHL 100

                         90       100
                 ....*....|....*....|....*.
gi 489188292 142 DDVLPVWRECARVLRPGGKLLASFYN 167
Cdd:COG2227  101 PDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 66-159 3.80e-17

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 74.52  E-value: 3.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292   66 ILCLASAGGQQAPILAAA-GARVTLFDASAGQLDKDRQVAARDRLELACVQGDMRDLStFADASFDLVF--NPISNLYVD 142
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLP-FPDGSFDLVVssGVLHHLPDP 79

                          90
                  ....*....|....*..
gi 489188292  143 DVLPVWRECARVLRPGG 159
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 66-166 5.78e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.91  E-value: 5.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  66 ILCL-ASAGGQQAPILAAAGARVTLFDASAGQLDKDRQVAAR---DRLELacVQGDMRDLSTFADASFDLVF-NPISNLY 140
Cdd:cd02440    2 VLDLgCGTGALALALASGPGARVTGVDISPVALELARKAAAAllaDNVEV--LKGDAEELPPEADESFDVIIsDPPLHHL 79

                         90       100
                 ....*....|....*....|....*.
gi 489188292 141 VDDVLPVWRECARVLRPGGKLLASFY 166
Cdd:cd02440   80 VEDLARFLEEARRLLKPGGVLVLTLV 105
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
114-201 1.98e-08

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 52.56  E-value: 1.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292 114 VQGDMRDLSTFADASFDLVFnpiSN-----LYVDDVLPVWRECARVLRPGGKL---------LASFYNPALFIEDRSPEL 179
Cdd:COG4627   32 IVGDLTDPLPFPDNSVDAIY---SShvlehLDYEEAPLALKECYRVLKPGGILrivvpdlehVARLYLAEYDAALDVAEL 108

                         90       100
                 ....*....|....*....|..
gi 489188292 180 AEQGLIRPRHRLPYSDLESLSA 201
Cdd:COG4627  109 RLAGPIDPLGIILGERLAGLAA 130
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
84-165 7.89e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 49.05  E-value: 7.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  84 GARVTLFDASAGQLDKdrqvaARDRL-ELACVQGDMRDLStfADASFDLVFnpiSNL---YVDDVLPVWRECARVLRPGG 159
Cdd:COG4106   25 GARVTGVDLSPEMLAR-----ARARLpNVRFVVADLRDLD--PPEPFDLVV---SNAalhWLPDHAALLARLAAALAPGG 94


                 ....*.
gi 489188292 160 KLLASF 165
Cdd:COG4106   95 VLAVQV 100
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 62-214 2.57e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 49.91  E-value: 2.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  62 RGREILCLASAGGQQAPILAAA-GARVTLFDASAGQLDKDRQVAAR---DRLELacVQGDMRDLSTFADASFDLV--FNP 135
Cdd:COG0500   26 KGGRVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALARARAAKaglGNVEF--LVADLAELDPLPAESFDLVvaFGV 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489188292 136 ISNLYVDDVLPVWRECARVLRPGGKLLASFYNPALFIEDRSPELAEQGLIRPRHRLPYSDLESLSAEALAAKREKGEAL 214
Cdd:COG0500  104 LHHLPPEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLATASLLELLLLLRLLALELYLRALLAAAATEDLR 182
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 82-161 2.75e-07

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 50.53  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  82 AAGARVTLFDASAGQLDKDRQVAARDRLelacVQGDMRDLsTFADASFDLVFnpiSNLYV---DDVLPVWRECARVLRPG 158
Cdd:PRK10258  62 ERGSQVTALDLSPPMLAQARQKDAADHY----LAGDIESL-PLATATFDLAW---SNLAVqwcGNLSTALRELYRVVRPG 133


                 ...
gi 489188292 159 GKL 161
Cdd:PRK10258 134 GVV 136
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
58-165 3.13e-07

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 49.23  E-value: 3.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  58 LGDVRGREILCLASAGGQQAPILAAAGARVTLFDASAGQLDKdrqvAARDRLELACVQGDMRDLsTFADASFDLVfnpIS 137
Cdd:COG4976   42 LPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAK----AREKGVYDRLLVADLADL-AEPDGRFDLI---VA 113

                         90       100       110
                 ....*....|....*....|....*....|.
gi 489188292 138 NL---YVDDVLPVWRECARVLRPGGKLLASF 165
Cdd:COG4976  114 ADvltYLGDLAAVFAGVARALKPGGLFIFSV 144
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 63-162 5.44e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 48.39  E-value: 5.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  63 GREILCLASAGGQQAPILAAA-GARVTLFDASAGQLDKDRQVAAR----DRLELacVQGDMRDLstFADASFDLVFNP-- 135
Cdd:COG2230   52 GMRVLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYARERAAEaglaDRVEV--RLADYRDL--PADGQFDAIVSIgm 127

                         90       100       110
                 ....*....|....*....|....*....|
gi 489188292 136 ---ISNLYVDDVLpvwRECARVLRPGGKLL 162
Cdd:COG2230  128 fehVGPENYPAYF---AKVARLLKPGGRLL 154
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 57-162 1.09e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 48.61  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  57 WLGDVRGREILCLASAGGQQAPILAAAG---ARVTLFDASAGQLDkdrqvAARDRLELAC-------VQGDMRDLStFAD 126
Cdd:PRK00216  46 WLGVRPGDKVLDLACGTGDLAIALAKAVgktGEVVGLDFSEGMLA-----VGREKLRDLGlsgnvefVQGDAEALP-FPD 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 489188292 127 ASFDLVfnPIS----NlyVDDVLPVWRECARVLRPGGKLL 162
Cdd:PRK00216 120 NSFDAV--TIAfglrN--VPDIDKALREMYRVLKPGGRLV 155
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 77-161 1.45e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 45.82  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292   77 APILAA-AGARVTLFDASAGQLDK-DRQVAARDRLELACVQGDMRDLSTFADASFDLVFnpISNL--YVDDVLPVWRECA 152
Cdd:pfam08242  12 RALLEAlPGLEYTGLDISPAALEAaRERLAALGLLNAVRVELFQLDLGELDPGSFDVVV--ASNVlhHLADPRAVLRNIR 89


                  ....*....
gi 489188292  153 RVLRPGGKL 161
Cdd:pfam08242  90 RLLKPGGVL 98
PRK08317 PRK08317
hypothetical protein; Provisional
 62-164 1.73e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 48.01  E-value: 1.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  62 RGREILCLASAGGQQAPILAAA---GARVTLFDASAGQLDKDRQVAARDRLELACVQGDMRDLStFADASFDLVFNPISN 138
Cdd:PRK08317  19 PGDRVLDVGCGPGNDARELARRvgpEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGLP-FPDGSFDAVRSDRVL 97

                         90       100
                 ....*....|....*....|....*.
gi 489188292 139 LYVDDVLPVWRECARVLRPGGKLLAS 164
Cdd:PRK08317  98 QHLEDPARALAEIARVLRPGGRVVVL 123
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 57-162 2.73e-06

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 47.26  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292   57 WLGDVRGREILCLASAGGQQAPILA---AAGARVTLFDASAGQLDKDRQVAARDrLELACVQGDMRDLStFADASFDLV- 132
Cdd:TIGR01934  34 LIGVFKGQKVLDVACGTGDLAIELAksaPDRGKVTGVDFSSEMLEVAKKKSELP-LNIEFIQADAEALP-FEDNSFDAVt 111

                          90       100       110
                  ....*....|....*....|....*....|..
gi 489188292  133 --FNpISNlyVDDVLPVWRECARVLRPGGKLL 162
Cdd:TIGR01934 112 iaFG-LRN--VTDIQKALREMYRVLKPGGRLV 140
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 85-199 7.00e-06

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 46.13  E-value: 7.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292   85 ARVTLFDASAGQLdkdRQVAARDRLELACVQGDMRDLStFADASFDLVFnpiSNL---YVDDVLPVWRECARVLRPGGKL 161
Cdd:TIGR02072  59 AEFIALDISAGML---AQAKTKLSENVQFICGDAEKLP-LEDSSFDLIV---SNLalqWCDDLSQALSELARVLKPGGLL 131

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489188292  162 LASFYNPALFIEDRSpelaeqglIRPRHRLPYSDLESL 199
Cdd:TIGR02072 132 AFSTFGPGTLHELRQ--------SFGQHGLRYLSLDEL 161
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 84-164 2.17e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 40.48  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292   84 GARVTLFDASAGQLDKDRQVAAR---DRLELAcvQGDMRDL-STFADASFDLVF-----NPISNLyvDDVLpvwRECARV 154
Cdd:pfam13847  28 NAEVVGIDISEEAIEKARENAQKlgfDNVEFE--QGDIEELpELLEDDKFDVVIsncvlNHIPDP--DKVL---QEILRV 100

                          90
                  ....*....|
gi 489188292  155 LRPGGKLLAS 164
Cdd:pfam13847 101 LKPGGRLIIS 110
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
114-175 4.93e-04

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 40.29  E-value: 4.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292 114 VQGDMRD-LSTFADASFDLVF---------------NPISN-----LYVDDVLPVWRECARVLRPGGkllaSFYnpaLFI 172
Cdd:COG0863    3 ICGDCLEvLKELPDESVDLIVtdppynlgkkyglgrREIGNelsfeEYLEFLREWLAECYRVLKPGG----SLY---VNI 75


                 ...
gi 489188292 173 EDR 175
Cdd:COG0863   76 GDR 78
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 67-159 1.25e-03

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 38.63  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  67 LCLASAggqqapilAAAGARVTLFDasagqLDKDRQVAARDRLELA-------CVQGDMRD-LSTFADASFDLVFnpisn 138
Cdd:COG4122   32 LWLARA--------LPDDGRLTTIE-----IDPERAAIARENFARAgladrirLILGDALEvLPRLADGPFDLVF----- 93

                         90       100
                 ....*....|....*....|....*
gi 489188292 139 lyVD----DVLPVWRECARVLRPGG 159
Cdd:COG4122   94 --IDadksNYPDYLELALPLLRPGG 116
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 85-162 6.05e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.80  E-value: 6.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292   85 ARVTLFDASAGQLDKDRQVAARDRLELA-CVQGDMrdLSTFADASFDLVfnpISN------LYVDDVLpVWR---ECARV 154
Cdd:pfam05175  56 AELTMVDINARALESARENLAANGLENGeVVASDV--YSGVEDGKFDLI---ISNppfhagLATTYNV-AQRfiaDAKRH 129


                  ....*...
gi 489188292  155 LRPGGKLL 162
Cdd:pfam05175 130 LRPGGELW 137
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
59-179 8.45e-03

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 36.65  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292   59 GDVRGREILCLASAGGQQA-PILAAAGAR--VTLFDASAGQLDKDRQVAARD---RLELacVQGDMRDLStFADASFDLV 132
Cdd:pfam01209  39 GVKRGNKFLDVAGGTGDWTfGLSDSAGSSgkVVGLDINENMLKEGEKKAKEEgkyNIEF--LQGNAEELP-FEDDSFDIV 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 489188292  133 FNPISNLYVDDVLPVWRECARVLRPGGKLLA-SFYNPALFIEDRSPEL 179
Cdd:pfam01209 116 TISFGLRNFPDYLKVLKEAFRVLKPGGRVVClEFSKPENPLLSQAYEL 163
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 80-162 9.20e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 36.32  E-value: 9.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489188292  80 LAAAGARVTLFDASAGQLDKDRQVAARDRLELA-CVQGDmrDLSTFADASFDLVF-NP---ISNLYVDDVlpVWR---EC 151
Cdd:COG2813   69 KRNPEARVTLVDVNARAVELARANAAANGLENVeVLWSD--GLSGVPDGSFDLILsNPpfhAGRAVDKEV--AHAliaDA 144

                         90
                 ....*....|.
gi 489188292 152 ARVLRPGGKLL 162
Cdd:COG2813  145 ARHLRPGGELW 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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