|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
11-368 |
1.77e-92 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 283.30 E-value: 1.77e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 11 LYFATLLMLTGSGLLSTYLALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHGL 90
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 91 LPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMILVAHPQLGPELLMLVAFCFAL 170
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 171 CLVPLALTHKIHPAALRPAPLEPRFFIRRVPQSLTTVLVSGLVVGSFYGLAPLYANQLGLPNEQVGLYMGACIFAGLLVQ 250
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 251 WPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQMPlALLLALGIAASMLQFTLYPLAVAFSNDHVETERRVSLTAMLL 330
Cdd:cd17477 241 WPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLP-LALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALL 319
|
330 340 350
....*....|....*....|....*....|....*...
gi 489189355 331 VTFGVGACIGPLAAGALMRLFGANMLYAFVSACALILV 368
Cdd:cd17477 320 LLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFL 357
|
|
| PRK03633 |
PRK03633 |
putative MFS family transporter protein; Provisional |
10-370 |
4.09e-35 |
|
putative MFS family transporter protein; Provisional
Pssm-ID: 179614 [Multi-domain] Cd Length: 381 Bit Score: 133.63 E-value: 4.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 10 ALYFATLLMLTGS-GLLSTYLALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGH 88
Cdd:PRK03633 9 LLLLCGLLLLTLAiAVLNTLVPLWLAQEHLPTWQVGVVSSSYFTGNLVGTLLAGYVIKRIGFNRSYYLASLIFAAGCAGL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 89 GLLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMILVAHPQLGPELLMLVAFCF 168
Cdd:PRK03633 89 GLMVGFWSWLAWRFVAGIGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYLGTVLGQLLVSKVSTELMSVLPWVTGLV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 169 ALCLVPLALTHKIHPAALRPAPLEPRFFIRRVPQSLTTV--LVSGLVVGSFYGLAPLYANQLGLPNEQVGLYMGACIFAG 246
Cdd:PRK03633 169 LAAILPLLFTRILNQQAENHDSTSIWPMLKLRQARLGVNgcIISGIVLGSLYGLMPLYLNHQGMSDASIGFWMALLVSAG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 247 LLVQWPLGWLSDRRDRAWLIRAcaillCLFALPLALLQQMPLALLLALGIAASMLQFTLYPLAVAFSNDHVETERRVSLT 326
Cdd:PRK03633 249 ILGQWPIGRLADRFGRLLVLRV-----QVFVVILGSIAMLSQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHELVAMN 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 489189355 327 AMLLVTFGVGACIGPLAAGALMRLFGANMLY---AFVSACALILVWR 370
Cdd:PRK03633 324 QALLLSYTVGSLLGPSFTAMLMQNYSDNLLFimiASVSFIYLLMLLR 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-337 |
4.33e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 110.83 E-value: 4.33e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 2 RRIFFSFRALYFATLLMLTGSGLLSTYLALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVV 81
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 82 TAAVLGHGLLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMI-LVAHPQLGPEL 160
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLgGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 161 LMLVAFCFALCLVPLALTHKIHPAALRPAPLEPRFF-IRRVPQSLTTVLVSGLVVGSFYG----LAPLYANQLGLPNEQV 235
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESRPAARARLRGSLReLLRRPRLLLLLLLAFLLGFGFFAlftyLPLYLQEVLGLSASAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 236 GLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQMPlaLLLALGIAASMLQFTLYPLAVAFSND 315
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLW--LLLLALFLLGFGFGLLFPLLQALVAE 323
|
330 340
....*....|....*....|..
gi 489189355 316 HVETERRVSLTAMLLVTFGVGA 337
Cdd:COG2814 324 LAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-341 |
6.98e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 93.25 E-value: 6.98e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 11 LYFATLLMLTGSGLLSTYLALRLAAD-KVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHG 89
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 90 LLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMI-LVAHPQLGPELLMLVAFCF 168
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLgGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 169 ALCLVPLALTHKIHPAALRPAPLEPR----------FFIRRVPQSLTTVLVSGLVVGSFYGLAPLYANQLGLPNEQVGLY 238
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEArlslivawkaLLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 239 MGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQMPLALLLALGI-AASMLQFTLYPLAVAFSNDHV 317
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALlLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 489189355 318 ETERRVSLTAMLLVTFGVGACIGP 341
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-370 |
1.22e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 93.02 E-value: 1.22e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 11 LYFATLLMLTGSGLLSTYLALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHGL 90
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 91 LPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMI-LVAHPQLGPELLMLVA---- 165
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLgGLLADALGYRAPFLVCaala 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 166 -FCFALCLVPLALTHKIHPAALRPAPLEPRFFI-----RRVPQSLTTVLVSGLVVGSFYGLAPLYANQL-GLPNEQVGLY 238
Cdd:cd17325 161 lLALVLALLLLPEPRPPPNKRAVSAARLRSGLRlllrdRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 239 MGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQMPlaLLLALGIAASMLQFTLYPLAVAFSNDHVE 318
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFW--LLLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 489189355 319 TERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLYAF---VSACALILVWR 370
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAaaaLLLLAAVLFLL 373
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
41-367 |
2.49e-17 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 82.65 E-value: 2.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 41 LWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHGLLPWLPAWIALRMVMGLGLMCQYMVIESWLN 120
Cdd:cd17316 36 LQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 121 EQADASQRGAVFGGYMAASYLGLVLG-QMILVAHPQLGPELLMLVAFCFALCLVPLALthkihpaalrpapleprFFIRR 199
Cdd:cd17316 116 EFAPSKRRGFALGLLQSGWALGALLAaLVASLLIPLLSGDWGWRILFLIGALPALLAL-----------------LLRRR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 200 VPQSLTTVLVSGLVVGSFYGLAP-LYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFAL 278
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPtYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 279 PLALLQQMPLALLLALGIAASMLQFTLYPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLYA 358
Cdd:cd17316 259 PLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA 338
|
....*....
gi 489189355 359 FVSACALIL 367
Cdd:cd17316 339 LILALLAIV 347
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
42-371 |
1.74e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.61 E-value: 1.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 42 WVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHGLLPWLPAWIALRMVMGLGLMCQYMVIESWLNE 121
Cdd:COG2807 54 QAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKR 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 122 QAdASQRGAVFGGYMAASYLGLVLGQMILVA-HPQLG--PELLMLVAFCFALCLVPLALTHKIHPAALRPAPLEPRFFIR 198
Cdd:COG2807 134 WF-PDRVGLMTGLYTAAMGLGAALAAGLTVPlAAALGwrGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLW 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 199 RVPQSLTTVLVSGLVVGSFYGL---APLYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDR-RDRAWLIracAILLC 274
Cdd:COG2807 213 RSPLAWLLTLFFGLQSLLYYAVvawLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRlGDRRPLL---LLLGL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 275 LFALPLALLQQMPLALLLALGIAASMLQFTLYPLAVAFSNDHVETERRV-SLTAMLLVTFGVGACIGPLAAGALMRLFG- 352
Cdd:COG2807 290 LGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAaALSGMAQSVGYLLAALGPLLVGALHDATGs 369
|
330 340
....*....|....*....|..
gi 489189355 353 ---ANMLYAFVSACALILVWRV 371
Cdd:COG2807 370 wtaALLLLAALAVLMLVAGLLA 391
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-366 |
1.80e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 77.22 E-value: 1.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 2 RRIFFSFRALYFATLLMLTGSGLLSTYLALRLAADKVDglwVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVV 81
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQ---LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 82 TAAVLGHGLLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMILVA-HPQLGPEL 160
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWlLAAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 161 LMLVAFCFALCLVPLALthkihpaalrpapleprffirrvpqsLTTVLVSGLVVGSFYGLA----PLYANQLGLPNEQVG 236
Cdd:COG2271 166 AFLILGLPGLLLALLRF--------------------------WLLALAYFLVYFALYGFLtwlpTYLVEVRGLSLAQAG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 237 LYMGACIFAGLLVQWPLGWLSDR--RDRAWLIRACAILLCLFALPLALLQqmPLALLLALGIAASMLQFTLYPLAVAFSN 314
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAALALLLLALLP--SPALAIALLFLAGFGLGGAFGLLWALAA 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 489189355 315 DHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLYAFVSACALI 366
Cdd:COG2271 298 ELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALL 349
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
43-371 |
3.27e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 76.84 E-value: 3.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 43 VGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHGLLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQ 122
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 123 ADASQRGAVFGGYMAASYLGLVLGQMIL-VAHPQLGPELLMLVAFCFALCLVPLALT----HKIHPAALRPAPLEPRFFI 197
Cdd:COG2223 122 FPPDRRGLALGLAAGGGNLGAAVAAFLApLLIAAFGWRNAFLILGILLLVVAVLAWLflrdPPAGAAAAAKASLRDQLEA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 198 RRVPQSLTTVLVSGLVVGSFYG----LAPLYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILL 273
Cdd:COG2223 202 LRDPRFWLLSLLYFGTFGSFIGfsswLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALM 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 274 CLFALPLALLQQMPLALLLALGIAASMLQFTlYPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFG- 352
Cdd:COG2223 282 ALGLLLLALALGSLWLFLVLFLLLGLALGGG-NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGs 360
|
330 340
....*....|....*....|..
gi 489189355 353 ---ANMLYAFVSACALILVWRV 371
Cdd:COG2223 361 ytaAFLVFAVLALVALVLTLLL 382
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
11-372 |
4.22e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 76.48 E-value: 4.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 11 LYFATLLMLTGSGLLSTYLALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHGL 90
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 91 LPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMI-LVAHPQLGPELLMLVAF--- 166
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALgLFLYQHLGFAVLFIVAAvla 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 167 --CFALCLVPLALTHKIHPAALRPAPLEPRFFIRRVPQSLTTVLVSGLVVGSFYGLAPLYANQLGLPNeqVGLYMGACIF 244
Cdd:cd17489 161 llALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN--AGLFFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 245 AGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQMPLALLLALGIAA--SMLQFTLYPLAVafsnDHVETERR 322
Cdd:cd17489 239 ALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLgfGLLFPALQALAV----DLVPPHRR 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489189355 323 VSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLYAF---VSACALILVWRVH 372
Cdd:cd17489 315 GAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLaavVVLLALVLYIFLL 367
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-369 |
1.87e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 71.42 E-value: 1.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 1 MRRIFFSFRALYFATLLMLTGSGLLSTYLALRLAADKVDglwVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGV 80
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQ---AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 81 VTAAVLGHGLLPWLPAWIALRMVMGLGLMCQYMVIESWLN--EQADASQR----GAVFG-GYMAASYLGLVLGQMILVAH 153
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAalGPETAASRlnllHAFFSlGALLGPLLGGLLILLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 154 PQLGPELLMLVAFCFALCLVPLALTHKIHPAALRPAPLEPRFFIRRVPQSLTTVLVSGLVVG---SFYGLAPLYANQ-LG 229
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGaegAIGDWLPLYLKDvLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 230 LPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQMPLALLLALGIAASMLqfTLYPLA 309
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLS--LMFPTI 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 310 VAFSNDHVEtERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLYAFVSACALILVW 369
Cdd:COG0738 321 FSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILL 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-369 |
7.70e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 69.38 E-value: 7.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 11 LYFATLLMLTGSGLLSTYLALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHGL 90
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 91 LPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQ---MILVAHPQLG-PELLMLVAF 166
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPllgGILASSLGFGwRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 167 CFALCLVPLALTHKIHPAALRPAP--------LEPRFFIRRVPQSLTTVLVSGLVVGSFYGLAPLYA----NQLGLPNEQ 234
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNeeassksvLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPlfllDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 235 VGLYMGACIFAGLLVQWPLGWLSDR-RDRAWLIRACAILLCLFALPLALLqqMPLALLLALGIAASMLQFTLYPLAVAFS 313
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLA--PSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 314 NDHVETERRVSLTAMLLVTFGVGACIGPLAAGALM----RLFGANMLYAFVSACALILVW 369
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaatfGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
10-369 |
1.99e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 68.37 E-value: 1.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 10 ALYFATLLMLTGSGLLSTYLALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHG 89
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 90 LLPWLPAWIALRMVMGLG---LMCQYMVIeswLNEQADASQRGAVFGGYMAASYLGLVLGQMI---LVAH----PQLGPE 159
Cdd:cd17474 83 LSDSFALLLAGRALQGIGaagLGPLALTL---IGDLFEGGERAKAMGLYEAALGLGIAVGPLLgglLAAIswryPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 160 LLMLVAFCFALCLVPlaltHKIHPAALRPAPLEPRFFIRRVPQSLTTVLVSGLVV----GSFYGLAPLYANQL-GLPNEQ 234
Cdd:cd17474 160 ALIPVAFLAILFLLP----EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYfflyFAFLTYLPFLLELLyGISPII 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 235 VGLYMGACIFAGLLVQWPLGWLSDRRDRAwlIRACAILLCLFALPLALLQQMPLALLLALGIAASMLQFTLY-PLAVAFS 313
Cdd:cd17474 236 IGLLFAGWSVLLALGSLFVGRLLKKRFGA--RRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNlPLLTTLV 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 489189355 314 NDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLYAFVSACALILVW 369
Cdd:cd17474 314 TELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
206-374 |
5.92e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 60.37 E-value: 5.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 206 TVLVSGLVVGSFYGLAPLYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQ 285
Cdd:COG2814 18 GAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 286 MPLALLLALGIaaSMLQFTLYPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLY---AFVSA 362
Cdd:COG2814 98 LWLLLAARFLQ--GLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFlvnAVLAL 175
|
170
....*....|..
gi 489189355 363 CALILVWRVHPE 374
Cdd:COG2814 176 LALLLLLRLLPE 187
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-178 |
1.40e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.55 E-value: 1.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 2 RRIFFSFRALYFATLLMLTGSGLLSTYLALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVV 81
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 82 TAAVLGHGLLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMIL-VAHPQLGPEL 160
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAgLLADALGLSA 364
|
170
....*....|....*...
gi 489189355 161 LMLVAFCFALCLVPLALT 178
Cdd:cd06173 365 VFLLAGALLLLAALLLLL 382
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
9-366 |
1.48e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 59.55 E-value: 1.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 9 RALYFATLLMLTGSGLLSTYLALRLAADKVDGLW-VGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLG 87
Cdd:cd17329 2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASiVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 88 HGLLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMILVAHPQLGPELLMLVAF- 166
Cdd:cd17329 82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAv 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 167 CFALCLVPLALTHKIHPAALRPAPLEPrfFIRRVPQSLT---------TVLVSGLVVGSFYGLAPLYANQ-LGLPNEQVG 236
Cdd:cd17329 162 LFLLAALVLLFLLPETRPKRRAAEKTE--ILRGYKIVLRdrafllfllASFLISLIYFQLESTLPVYVVEiLGLGESLLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 237 LYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQMPLALLlalgiaaSMLQFTL-----YPLAVA 311
Cdd:cd17329 240 LLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLIL-------AMIVLTLgemlvFPAVQT 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 489189355 312 FSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLYAFVSACALI 366
Cdd:cd17329 313 LVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLI 367
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
44-367 |
9.26e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 56.93 E-value: 9.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 44 GALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHGLLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQA 123
Cdd:cd06180 37 GWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 124 DASQRGAVFGGYMAASYLGLVLGQMILVAHPQLG---PELLMLVAFCFALCLVPLALTHKIHPAALRPAPLEPRFFIRRV 200
Cdd:cd06180 117 TAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGlswRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 201 PQSLTTVLvsglvvgsfYGLA-----------PLYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRD-RAWLIRA 268
Cdd:cd06180 197 PLWRLALA---------YGLFgfgyiitatflPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGtRRALAAN 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 269 CAILLCLFALPLAllqqMPLALLLALGIAASMLQFTLYPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALM 348
Cdd:cd06180 268 LLVQAVGVLLPLL----SPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRALALMTASFGVGQILGPLLAGWLA 343
|
330
....*....|....*....
gi 489189355 349 RLFGANMLYAFVSACALIL 367
Cdd:cd06180 344 DATGGFAPALILAAAALVV 362
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
204-375 |
1.35e-08 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 56.40 E-value: 1.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 204 LTTVLVSGLVVGSFYGLAPLY-ANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRR-DRAWLIRACAILLCLFALPLA 281
Cdd:cd17471 2 LLATLLTGLAGAFVLPYLSLFlTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGgDRKPLILLALLAGALGYLLFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 282 LLQQMPLALLLALGIAAsmLQFTLYPLAVAFSNDHVE---TERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLYA 358
Cdd:cd17471 82 FLRNYWVLLLVGVVLLS--LGAAAFPQLFALAREYADrssGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFL 159
|
170 180
....*....|....*....|
gi 489189355 359 FVSAC---ALILVWRVHPEK 375
Cdd:cd17471 160 LAALLylvVALLVLFLLPSV 179
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
204-378 |
6.85e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.96 E-value: 6.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 204 LTTVLVSGLVVGSFYGLAPLY-ANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLAL 282
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 283 LQQMPLALLLALGIaaSMLQFTLYPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFG---ANMLYAF 359
Cdd:pfam07690 82 ASSLWLLLVLRVLQ--GLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGwraAFLILAI 159
|
170
....*....|....*....
gi 489189355 360 VSACALILVWRVHPEKVSG 378
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESK 178
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
8-368 |
1.85e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.00 E-value: 1.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 8 FRALYFATLLMLTGSGLLSTYLALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVAC---AGVVTAA 84
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 85 VLGHGLLPWLPAWIALRMVMGLGLMCQYM--VIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMI---LVAHpqLGPE 159
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFgpARQALLPELVPKEQLVRANALNSLATQLARIIGPALgglLVAL--LGPG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 160 LLMLV-AFCFALCLVPLALTHKIHPAALRPAPLEP--------RFFIRRVP--QSLTTVLVSGLVVGSFYGLAPLYA-NQ 227
Cdd:cd06173 159 GAFAInALSFLLSALLLLFIRRPPPAAPGESSSLLlrdlreglRYLRRSPLlrLLLLALALFALLGGALTVLLPLLAkEV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 228 LGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQMPLALLLALGIAASMLQFTLYp 307
Cdd:cd06173 239 LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVP- 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489189355 308 lAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLYAFVSACALILV 368
Cdd:cd06173 318 -LNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAA 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
204-405 |
2.28e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.58 E-value: 2.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 204 LTTVLVSGLVVGSFYGLAPLYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALL 283
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 284 QQMPLALLLALGIAASMLQFTlyPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLYAFVSAC 363
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVW--PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 489189355 364 ---ALILVWRVHPEKVSGLHRVDDAPLHHVPTPDNMTSSPLVAAL 405
Cdd:cd17325 160 allALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLAL 204
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
24-278 |
2.69e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 52.30 E-value: 2.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 24 LLSTYLALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVAcaGVVTAAVLGhGLLPWLPAWIAL--- 100
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVI--TILLFAVFT-LLCGFAQNYWQLlil 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 101 RMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVL-----GQMILVAHPQLGPELLMLVAFCFALCLVPL 175
Cdd:cd17371 94 RALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLatllaALLFPLLPPEIAWRVLFLLGALPALLVLFI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 176 ALTHKIHP----AALRPAPLEPRFFIRRV------PQSLTTVLVSGLVVGSFYGLA---PLYAN-QLGLPNEQVGLYMGA 241
Cdd:cd17371 174 RRFVKEPPqwqaARAARRHFADRPSLRELfsppllRTTLLASLLATGALGGYYGITtwlPSYLTgERGLSFEGSAGYLVV 253
|
250 260 270
....*....|....*....|....*....|....*..
gi 489189355 242 CIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFAL 278
Cdd:cd17371 254 TILGGFLGYLAGGFLADRIGRRNNFALFALGSAISIL 290
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
63-352 |
2.88e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.60 E-value: 2.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 63 RLIARVGHIRAYVACAGVVTAAVLGhgLLPWLPAW---------IALRMVMGLGLMCQYMVIESWLNEQA-DASQRGAVF 132
Cdd:COG2211 72 RTRTRWGRRRPWILIGAIPLALSFV--LLFTAPDLsptgkliyaLVTYLLLGLAYTLVNIPYSALGAELTpDYEERTRLS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 133 GGYMAASYLGLVLGQMI-------LVAHPQLGPELLMLV--AFCFALCLVPLALTHKIHPAALRPAPLepRFFIRRVPQS 203
Cdd:COG2211 150 SWRFAFAGLGGLLASVLppplvaaFGGDAALGYRLTALIfaVLGLLAFLLTFFGTKERPVPEEEKVSL--KESLKALLKN 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 204 ------LTTVLVSGLVVGSFYGLAPLYA-NQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLF 276
Cdd:COG2211 228 rpflllLLAYLLFFLALALVAALLLYYFkYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 277 ALPLALLQQMPLALLLALGIAASMLQFTLYPLAVAFSNDHVE-----TERRVSLTAMLLVTFGVGAC--IGPLAAGALMR 349
Cdd:COG2211 308 LLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewkTGRRREGLYFGIFTFAIKLGqaLAGALAGLLLA 387
|
...
gi 489189355 350 LFG 352
Cdd:COG2211 388 LFG 390
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
43-369 |
3.07e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.17 E-value: 3.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 43 VGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHGLLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQ 122
Cdd:cd17324 36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 123 ADASQRGAVFGGYMAASYLGLVLGQMI--LVAhPQLGPELLMLVAFCFALCLVPL---ALTHKIHPAALRPAPLEPRFFI 197
Cdd:cd17324 116 VPPEKRGRAIGLVFSGLTLGLVLGRPLggLLG-QLLGWRAAFLAIAVLALLAALLlwrLLPSLPPKKPGSLGLLSSLLLL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 198 RRVPQSLTTVLVSGLVVGSFYG----LAPLYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRR-DRAWLIRACAIL 272
Cdd:cd17324 195 LRNPRLRLAYLITFLLFGGFFAlytyLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGgRRALLIALLLLA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 273 LCLFALPLALLQqmpLALLLALGIAASMLQFTLYPLAVAFSNDhVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFG 352
Cdd:cd17324 275 AALLLLTLLGPS---PLLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGG 350
|
330 340
....*....|....*....|
gi 489189355 353 ANMLY---AFVSACALILVW 369
Cdd:cd17324 351 WAGVGwvgAALLLLALLLAL 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
9-178 |
6.95e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.01 E-value: 6.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 9 RALYFATLLMLTGSGLLSTYLALRLAAD-KVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLG 87
Cdd:cd17324 201 RLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 88 HGLLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASqRGAVFGGYMAASYLGLVLGQMI---LVAHpqlgPELLMLV 164
Cdd:cd17324 281 TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALgglVLDH----GGWAGVG 355
|
170
....*....|....
gi 489189355 165 AFCFALCLVPLALT 178
Cdd:cd17324 356 WVGAALLLLALLLA 369
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-283 |
1.45e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.81 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 10 ALYFATLLMLTGSGLLSTYLALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHG 89
Cdd:COG0477 18 ALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 90 LLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMI---LVAHPQLGPELLMLVAF 166
Cdd:COG0477 98 LAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLgglLVAALGWRWIFLINAPL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 167 CFALCLVPLALTHKIHPAALRPAPLEPRFFIRRVPQSLTTVLVSGLVVGSFYGLAPLYANQLGLPNEQVGLYMGACIFAG 246
Cdd:COG0477 178 GLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALL 257
|
250 260 270
....*....|....*....|....*....|....*..
gi 489189355 247 LLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALL 283
Cdd:COG0477 258 LLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
123-366 |
1.56e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 123 ADASQRGAVFGGYMAASYLGLVLGQ---MILVAHPQLGPELLMLVAFCFALC-LVPLALTHKIHPAALRPAPLEPRFFIR 198
Cdd:cd17370 117 TPPSGRGKAFGLHRALDTLGAVLGPllaALLLYLLGGNYRTIFLLAAIPALLaLLILLFVVKEYPRPPKLRKKSKKTSLK 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 199 RVPQSLTTVLVSGLVVG---SFYGLAPLYANQLGLPNEQV----GLYMGACIFAGLlvqwPLGWLSDRRDRAWLIraCAI 271
Cdd:cd17370 197 KLPKAFWLYLLAVALFAlgnFSFAFLILRAQELGLSAALIpllyALFNLVYALAAY----PAGRLSDRIGRKKLL--ILG 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 272 LLCLFALPLALLQQMPLALLLALGIAASM---LQFTLYPLAVAfsnDHVETERRVSLTAMLLVTFGVGACIGPLAAGALM 348
Cdd:cd17370 271 YLSLALAYLGFALGSSLWLLLLGFILWGLymgAQESIERAAVA---DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLW 347
|
250
....*....|....*...
gi 489189355 349 RLFGANMLYAFVSACALI 366
Cdd:cd17370 348 DLISPSAAFLFSAVLALI 365
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
207-377 |
4.04e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.74 E-value: 4.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 207 VLVSGLVVGSFYGLA----PLYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLAL 282
Cdd:cd17489 1 ILLANFFFFLSFYLLlpvlPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 283 LQQMPLALLLALGIAASMLQFTlyPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLY---AF 359
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFT--TAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFivaAV 158
|
170
....*....|....*...
gi 489189355 360 VSACALILVWRVHPEKVS 377
Cdd:cd17489 159 LALLALLLVFLVKDPPPV 176
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
10-178 |
5.55e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.26 E-value: 5.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 10 ALYFATLLMLTGSGLLSTYLALRLAA-DKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGH 88
Cdd:cd17473 201 PIYFLAFLAMLLFYVIPIQLPFLLQErGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 89 GLLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLG-----LVLGQMILVAHpqlGPELLML 163
Cdd:cd17473 281 ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGqflspLVLGPLVNLTG---GLSGAFL 357
|
170
....*....|....*
gi 489189355 164 VAFCFALCLVPLALT 178
Cdd:cd17473 358 ILGVLALVLAIVLLL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
189-369 |
7.11e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.86 E-value: 7.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 189 APLEPRFFIRRVPQSLTTVLVSGLVVGSFYGLAPLYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRA 268
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 269 CAILLCLFALPLALLQQMPLALLLALGIAASmlQFTLYPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALM 348
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLG--EAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL 158
|
170 180
....*....|....*....|.
gi 489189355 349 RLFGANMLYAFVSACALILVW 369
Cdd:COG2271 159 AAFGWRAAFLILGLPGLLLAL 179
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
10-368 |
2.85e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 42.95 E-value: 2.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 10 ALYFATLLMLTGSGLLSTYL-ALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGhiRAYVACAGVVTAAVLGH 88
Cdd:cd17473 3 TLLLASTLTVMAGAAIAPALpAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFG--RKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 89 G--LLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMI---LVAHPQLGPELLML 163
Cdd:cd17473 81 AglFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLggaLAEIGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 164 VAFCFALcLVPLALTHKIHPAALRPAPLEPRFFIRRVPQSLTTVLVSGLVVGSFYGLA---PLYANQLGLPNE-QVGLYM 239
Cdd:cd17473 161 LALPVLI-LVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPiqlPFLLQERGGGSAaLIGLAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 240 GACIFAGLLVQWPLGWLSDRRDRAWLIracAILLCLFALPLALLQQMPLALLLALGIAASMLQF-TLYPLAVAFSNDHVE 318
Cdd:cd17473 240 AIASLAGAIGALLFGRLKRRLGKRRLL---AIGFALMALGFLLLALASGLWVVLLGAILAGLGFgLLLPTLNSWAMSLVP 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 489189355 319 TERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGaNMLYAFVSACALILV 368
Cdd:cd17473 317 PELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG-GLSGAFLILGVLALV 365
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
11-368 |
3.14e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.57 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 11 LYFATLLMLTGSGLLSTYLAL---RLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLG 87
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFyvrEFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 88 HGLLPWLPAWIALRMVMGLgLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMILVAHPQLGPELLMLVaFC 167
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFL-VA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 168 FALCLVPLALTHkihpaalrpapleprFFIRRVPQSLTTVLVSGLVVGSFYGLAPLYANQ-LGLPNEQVGLYMGACIFAG 246
Cdd:cd17330 159 AALALLNLVLVL---------------FFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDrFGFSPSQIGLLLALVGIAG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 247 LLVQWPL-GWLSDRRDRAWLIRACAILLCLFALPLALLQQMPLALLLALGIAASMLqfTLYPLAVAFSNDHVETERRVSL 325
Cdd:cd17330 224 ILAQLLLiPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTG--IVFPALSALLSKSVPSKEQGKA 301
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 489189355 326 TAMLLVTFGVGACIGPLAAGALMRLFGANMLYAFVSACALILV 368
Cdd:cd17330 302 QGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIAL 344
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
44-371 |
3.98e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.17 E-value: 3.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 44 GALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHGLLPWLPAWIALRMVMGLGLMCQYMVIESWLNEQA 123
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 124 DASQRGAVFGGYMAASYLGLVLGQMILVAhpqlgpelLML-----VAFcFALCLVPLALThkihpaalrpaplepRFFIR 198
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGW--------LLLlfgwrWAF-IIEGLLGLLLA---------------VLWWF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 199 RVPQSLTTVLVSGLVVGSFYGLA---PLY-ANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRD---RAWLIRACAI 271
Cdd:cd17319 177 YLRQVWGLALGYFGINYALYGLLtwlPTYlKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLrgaRRLVIIIGLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 272 LLCLFALPLALLQQMplALLLALGIAASMLQFTLYPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLF 351
Cdd:cd17319 257 LAAVGLLLAYLTTSP--VVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAT 334
|
330 340
....*....|....*....|....
gi 489189355 352 GANMLY----AFVSACALILVWRV 371
Cdd:cd17319 335 GSYTAAflflAAVALLAALLVLLL 358
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
38-369 |
4.58e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.18 E-value: 4.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 38 VDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTAAVLGHGLLPWLPAWIALRMVMGLGLMCQYMVIES 117
Cdd:cd17320 31 ASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 118 WLNEQADASQRGAVFG----GYMAASYLGLVLGQMIL-VAHPQLGPELLMLVAF-CFALCLVPLALTHKIHPAALRPAPL 191
Cdd:cd17320 111 IVRDLYSGAELAKIFSllmmILAIAPALAPLLGGLLLlFFGWRAIFVFLALLGLlLLLLVLLFLPETLPEEKRKPLLSSL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 192 EPRFF-IRRVPQSLTTVLVSGLVVG---SFYGLAP-LYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLI 266
Cdd:cd17320 191 LRAYKrVLKNRRFLGYALALGLSFAglfAYLAAAPfIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 267 R---ACAILLCLFALPLALLQQMPLALLLALGIAASMLQFTLYPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLA 343
Cdd:cd17320 271 RlglLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALV 350
|
330 340
....*....|....*....|....*.
gi 489189355 344 agALMRLFGANMLYAFVSACALILVW 369
Cdd:cd17320 351 --GLLPNGTALPMGLLILVLGLLALL 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
221-369 |
4.81e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.22 E-value: 4.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 221 APLYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQMPLALLLALGIAASM 300
Cdd:cd06173 22 LPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFL 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489189355 301 LQFT---LYPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLYAFVSACALILVW 369
Cdd:cd06173 102 LGIAsafFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSAL 173
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
8-368 |
2.11e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.95 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 8 FRALYFATLLMLTGSGLLSTY----LALRLAADKVDGLWVGALMAANYFGLVLGGKVGHRLIARVGHIRAYVACAGVVTA 83
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYfgvfIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 84 AVLGHGLLPWLPAWIALRMVM-GLGLMCQYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMILVAHPQLGPELLM 162
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLgGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 163 LVAFCF--ALCLVPLAL------THKIHPAALRPAPLEPRFFIRRVPQS------LTTVLVSGLVVGSFYGLAPLYANQL 228
Cdd:cd17355 161 LLVLALlaLLVLVPVLLllrrrpADLALRAYDDASPASPGSTLKEALRSasfwllALAFFLCGFAVVGLIVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 229 GLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLiraCAILLCLFALPLALLQQMPLALLLALGIAASM--LQFTLY 306
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRL---LAASYALRALGLALLLLLPFPPLALLLFAALFglGWGATV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489189355 307 PLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGaNMLYAFVSACALILV 368
Cdd:cd17355 318 PLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG-SYTAAWALAVALGLI 378
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
160-287 |
2.84e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.84 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 160 LLMLVAFCFALCLVPLALTHKIHPAALRPAPLEPRFFIRRVPQSLTTVLVS---GLVVGSFYGLA-PLY-ANQLGLPNEQ 234
Cdd:cd17471 157 LFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAftlLFAANSMYIIAmPLYvTNELGGSESW 236
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 489189355 235 VGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQMP 287
Cdd:cd17471 237 VGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLW 289
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
63-362 |
4.35e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.10 E-value: 4.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 63 RLIARVGHIRAYVACAGVVTAAVLGHGLLPWLPAWIALRMVMGLGL----MCQYMVIESWLNEQADASQrGAVFGGYMAA 138
Cdd:cd17504 53 RLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGavfpLAFALVREEFPPERVPVAQ-GILSATFGIG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 139 SYLGLVLGQmILVAHpqLGPEllMLVAFCFALCLVPLALTHKIHPAALRpapleprffIRRVPQSLTTVLVSGLVVGSFY 218
Cdd:cd17504 132 AGIGLPLGG-WIVQH--LGWR--WIFWTAAPVAVLLAALVPLIDLRLLR---------RRNVLLANITALLAGFGMFMVF 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 219 GLAPLYANQ-----LGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQMPLALLLA 293
Cdd:cd17504 198 QLLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVA 277
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489189355 294 LGIA---ASMLqFTLYPLAVAFSndhVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGANMLYAFVSA 362
Cdd:cd17504 278 LLLIgigLGLA-FASLPNIVVES---VPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGVPT 345
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
122-366 |
4.69e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.08 E-value: 4.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 122 QADASQRGAVFGGYMAASYLGLVLGQMI--LVAHPQLGPELLMLVAFCFALCLVPLALT-HKIHPAALRPAPLEPRFFIR 198
Cdd:cd17478 111 QAAGGRRGLAMSIFSVGGNLGFALGPLIaaALVALFGGLGLLILLIIPGLAVALLLLRLrPLKKPEAKKAAAKSSARSTL 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 199 RVPQSLTTVLVSGLVVGSFYGLA-----PLYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILL 273
Cdd:cd17478 191 KGVWRALLLLLIIVFLRSWVLSSlttflPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLA 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 274 clfALPLALLQQMPLALLLALGIAASMLQFTLYPLAVAFSNDHVetERRVSLTA--MLLVTFGVGAcIGPLAAGALMRLF 351
Cdd:cd17478 271 ---APFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL--PGNVGLASglMMGLSFGLGG-IGAPVLGALADAF 344
|
250
....*....|....*
gi 489189355 352 GANMLYAFVSACALI 366
Cdd:cd17478 345 GLESVLLILALLPLL 359
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
34-149 |
4.92e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.18 E-value: 4.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 34 AADKVDGLWVGALMAANYFGLVLGGKVGHRLiarvGHIRAYVACAGVVTAAVLGHGLLPWLPAWIAL---RMVMGLGLMC 110
Cdd:pfam00083 43 ALSVLSGLIVSIFSVGCFIGSLFAGKLGDRF----GRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGG 118
|
90 100 110
....*....|....*....|....*....|....*....
gi 489189355 111 QYMVIESWLNEQADASQRGAVFGGYMAASYLGLVLGQMI 149
Cdd:pfam00083 119 ASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIF 157
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
207-352 |
6.92e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.25 E-value: 6.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 207 VLVSGLVVGSFYGLAPLYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQM 286
Cdd:COG0477 23 TFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSP 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 287 PLALLLalgiaaSMLQ----FTLYPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFG 352
Cdd:COG0477 103 ELLIAA------RALQgigaGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
54-348 |
8.28e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.31 E-value: 8.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 54 LVLGGKVGhrliARVGHIRAYVACAGVVTAAVLGHGLLPWLPAWIALRMVMGLG---LMCQYMVIeswLNEQADASQRGA 130
Cdd:cd17321 48 LLLAGRLG----DRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGaaaIMPASLAL---IAATFPGERRGR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 131 VFGGYMAASYLGLVLGQMI---LVAHpqLGPELLMLVafCFALCLVPLALTHKIHPAalrpapleprffirrvpqSLTTV 207
Cdd:cd17321 121 ALGLWGAVVGIGAALGPLLgglLLEL--FGWRWIFLI--NVPIGLVALLLARTFSGA------------------VLAAF 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 208 LVSGLVVGSFYGLAPLYANQLGLPNEQVGLYMGACIFAGLLVQWPLGWLSDRRDRAWLIRACAILLCLFALPLALLQQMP 287
Cdd:cd17321 179 LLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADS 258
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489189355 288 LALLLALGIAASMLQFTLY--PLAVAFSNdHVETERRVSLTAMLLVTFGVGACIGPLAAGALM 348
Cdd:cd17321 259 SVWLLLPGLVLLGLGLGLFatPLTNAALS-SVPKEKAGAASGILNTARQLGGALGVALLGALL 320
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|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
197-367 |
8.31e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.35 E-value: 8.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 197 IRRVPQSLTTVLVSGLVVGSFYGLAPLYA-NQLGLPNEQVGLYMGACIFAGLLVQWPL-GWLSDRRDRAWLIRACAILLC 274
Cdd:cd17331 206 LPGVAFLLLVKLLSGLPIGMFQSMFSLVAmDFFGLTPEENGYLMSYAGVLGMVVQGLLvGPLTKRFGERSLLKLSVALLA 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189355 275 LFALPLALLQQMPLALLLALGIAASmlQFTLYPLAVAFSNDHVETERRVSLTAMLLVTFGVGACIGPLAAGALMRLFGAN 354
Cdd:cd17331 286 IGYLLLAFVTTVWQLLVLLLPLVIG--GSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFP 363
|
170
....*....|...
gi 489189355 355 MLYAFVSACALIL 367
Cdd:cd17331 364 SFGLLGAAINGLL 376
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