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Conserved domains on  [gi|489189686|ref|WP_003099064|]
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MULTISPECIES: VOC family protein [Pseudomonas]

Protein Classification

VOC family protein( domain architecture ID 10008083)

vicinal oxygen chelate (VOC) family protein uses a metal center to coordinate a substrate, intermediate, or transition state through vicinal oxygen atoms

CATH:  3.10.180.70
Gene Ontology:  GO:0046872|GO:0003824
PubMed:  21820381|11076500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3865 COG3865
Glyoxalase superfamily enzyme, possible 3-demethylubiquinone-9 3-methyltransferase [General ...
 3-158 1.25e-94

Glyoxalase superfamily enzyme, possible 3-demethylubiquinone-9 3-methyltransferase [General function prediction only];


:

Pssm-ID: 443074  Cd Length: 156  Bit Score: 270.48  E-value: 1.25e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189686   3 SKNTICLWYDNAALEAATFYAETFPDSAVLAVHSAPGDYPSGKEGDVLTVEFRVMGIPCLGLNGGPAFRHSEAFSFQVAT 82
Cdd:COG3865    2 QKITPCLWFDGQAEEAAEFYVSVFPDSRITAVTRYPEDGPGGPAGSVLTVEFTLAGQPFMALNGGPLFKFNEAVSFQVNC 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489189686  83 DDQAETDRLWNAIVDnGGEESACGWCRDKWGISWQITPRVLSEAIASPDRAAARRAFEAMMTMGRIDIATIEKAFK 158
Cdd:COG3865   82 EDQAEVDRLWDALSA-GGEESQCGWLKDRFGLSWQIVPRRLGELLADPDPAKAQRAMQAMMQMKKIDIAALEAAAR 156
 
Name Accession Description Interval E-value
COG3865 COG3865
Glyoxalase superfamily enzyme, possible 3-demethylubiquinone-9 3-methyltransferase [General ...
 3-158 1.25e-94

Glyoxalase superfamily enzyme, possible 3-demethylubiquinone-9 3-methyltransferase [General function prediction only];


Pssm-ID: 443074  Cd Length: 156  Bit Score: 270.48  E-value: 1.25e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189686   3 SKNTICLWYDNAALEAATFYAETFPDSAVLAVHSAPGDYPSGKEGDVLTVEFRVMGIPCLGLNGGPAFRHSEAFSFQVAT 82
Cdd:COG3865    2 QKITPCLWFDGQAEEAAEFYVSVFPDSRITAVTRYPEDGPGGPAGSVLTVEFTLAGQPFMALNGGPLFKFNEAVSFQVNC 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489189686  83 DDQAETDRLWNAIVDnGGEESACGWCRDKWGISWQITPRVLSEAIASPDRAAARRAFEAMMTMGRIDIATIEKAFK 158
Cdd:COG3865   82 EDQAEVDRLWDALSA-GGEESQCGWLKDRFGLSWQIVPRRLGELLADPDPAKAQRAMQAMMQMKKIDIAALEAAAR 156
3-dmu-9_3-mt pfam06983
3-demethylubiquinone-9 3-methyltransferase; This family represents a conserved region ...
 3-119 7.86e-67

3-demethylubiquinone-9 3-methyltransferase; This family represents a conserved region approximately 100 residues long within a number of bacterial and archaeal 3-demethylubiquinone-9 3-methyltransferases (EC:2.1.1.64). Note that some family members contain more than one copy of this region, and that many members are hypothetical proteins.


Pssm-ID: 399756  Cd Length: 116  Bit Score: 198.68  E-value: 7.86e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189686    3 SKNTICLWYDNAALEAATFYAETFPDSAVLAVHSAPGDYPsGKEGDVLTVEFRVMGIPCLGLNGGPAFRHSEAFSFQVAT 82
Cdd:pfam06983   1 QKITPCLWFDGQAEEAAEFYVSLFPNSEIGSVNRYPEDGP-GKPGSVLTVEFTLNGQPFIALNGGPNFKFNEAVSFQVTC 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 489189686   83 DDQAETDRLWNAIVDNGGEESACGWCRDKWGISWQIT 119
Cdd:pfam06983  80 KDQEEVDRYWNALSENGGPESQCGWLKDKFGVSWQIV 116
PhnB_like cd06588
Escherichia coli PhnB and similar proteins; The Escherichia coli phnB gene is found next to an ...
 6-119 1.12e-36

Escherichia coli PhnB and similar proteins; The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.


Pssm-ID: 319899  Cd Length: 129  Bit Score: 122.77  E-value: 1.12e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189686   6 TICLWYDNAALEAATFYAETFPDSAVLAVHSA---PGDYPSGKEGDVLTVEFRVMGIPCLGLNGGP--AFRHSEAFSFQV 80
Cdd:cd06588    2 TPYLWFNGNAEEALEFYAEVFPGGEILSLTRYgegPPDFPEGDEGKVMHAEFTLGGQTLMASDDGPgfPFTFGNAISLSV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489189686  81 ATDDQAETDRLWNAIVDNGGEE---------SACGWCRDKWGISWQIT 119
Cdd:cd06588   82 DCDSQEEADRLFEKLSEGGEVLmplqetfwgARYGWVKDKFGVSWQIN 129
 
Name Accession Description Interval E-value
COG3865 COG3865
Glyoxalase superfamily enzyme, possible 3-demethylubiquinone-9 3-methyltransferase [General ...
 3-158 1.25e-94

Glyoxalase superfamily enzyme, possible 3-demethylubiquinone-9 3-methyltransferase [General function prediction only];


Pssm-ID: 443074  Cd Length: 156  Bit Score: 270.48  E-value: 1.25e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189686   3 SKNTICLWYDNAALEAATFYAETFPDSAVLAVHSAPGDYPSGKEGDVLTVEFRVMGIPCLGLNGGPAFRHSEAFSFQVAT 82
Cdd:COG3865    2 QKITPCLWFDGQAEEAAEFYVSVFPDSRITAVTRYPEDGPGGPAGSVLTVEFTLAGQPFMALNGGPLFKFNEAVSFQVNC 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489189686  83 DDQAETDRLWNAIVDnGGEESACGWCRDKWGISWQITPRVLSEAIASPDRAAARRAFEAMMTMGRIDIATIEKAFK 158
Cdd:COG3865   82 EDQAEVDRLWDALSA-GGEESQCGWLKDRFGLSWQIVPRRLGELLADPDPAKAQRAMQAMMQMKKIDIAALEAAAR 156
3-dmu-9_3-mt pfam06983
3-demethylubiquinone-9 3-methyltransferase; This family represents a conserved region ...
 3-119 7.86e-67

3-demethylubiquinone-9 3-methyltransferase; This family represents a conserved region approximately 100 residues long within a number of bacterial and archaeal 3-demethylubiquinone-9 3-methyltransferases (EC:2.1.1.64). Note that some family members contain more than one copy of this region, and that many members are hypothetical proteins.


Pssm-ID: 399756  Cd Length: 116  Bit Score: 198.68  E-value: 7.86e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189686    3 SKNTICLWYDNAALEAATFYAETFPDSAVLAVHSAPGDYPsGKEGDVLTVEFRVMGIPCLGLNGGPAFRHSEAFSFQVAT 82
Cdd:pfam06983   1 QKITPCLWFDGQAEEAAEFYVSLFPNSEIGSVNRYPEDGP-GKPGSVLTVEFTLNGQPFIALNGGPNFKFNEAVSFQVTC 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 489189686   83 DDQAETDRLWNAIVDNGGEESACGWCRDKWGISWQIT 119
Cdd:pfam06983  80 KDQEEVDRYWNALSENGGPESQCGWLKDKFGVSWQIV 116
PhnB_like cd06588
Escherichia coli PhnB and similar proteins; The Escherichia coli phnB gene is found next to an ...
 6-119 1.12e-36

Escherichia coli PhnB and similar proteins; The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.


Pssm-ID: 319899  Cd Length: 129  Bit Score: 122.77  E-value: 1.12e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189686   6 TICLWYDNAALEAATFYAETFPDSAVLAVHSA---PGDYPSGKEGDVLTVEFRVMGIPCLGLNGGP--AFRHSEAFSFQV 80
Cdd:cd06588    2 TPYLWFNGNAEEALEFYAEVFPGGEILSLTRYgegPPDFPEGDEGKVMHAEFTLGGQTLMASDDGPgfPFTFGNAISLSV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489189686  81 ATDDQAETDRLWNAIVDNGGEE---------SACGWCRDKWGISWQIT 119
Cdd:cd06588   82 DCDSQEEADRLFEKLSEGGEVLmplqetfwgARYGWVKDKFGVSWQIN 129
PhnB COG2764
Zn-dependent glyoxalase, PhnB family [Energy production and conversion];
6-118 3.65e-03

Zn-dependent glyoxalase, PhnB family [Energy production and conversion];


Pssm-ID: 442048 [Multi-domain]  Cd Length: 118  Bit Score: 35.22  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189686   6 TICLWYDNAAlEAATFYAETFpDSAVLAVHSAPgdypsgkEGDVLTVEFR-----VMGIPClglNGGPAFRHSEAFSFQV 80
Cdd:COG2764    3 TPYLVVDDAE-EALEFYEDVF-GFEVVFRMTDP-------DGKIMHAELRiggsvLMLSDA---PPDSPAAEGNGVSLSL 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489189686  81 ATDDqaeTDRLWNAIVDNGGEE----------SACGWCRDKWGISWQI 118
Cdd:COG2764   71 YVDD---VDALFARLVAAGATVvmplqdtfwgDRFGMVRDPFGVLWMI 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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