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Conserved domains on  [gi|489190666|ref|WP_003100031|]
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MULTISPECIES: ornithine carbamoyltransferase [Pseudomonas]

Protein Classification

ornithine carbamoyltransferase( domain architecture ID 11479748)

ornithine carbamoyltransferase reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to L-ornithine (ORN) to produce L-citrulline, as part of the urea cycle and L-arginine biosynthesis

EC:  2.1.3.3
Gene Ontology:  GO:0005737|GO:0016597|GO:0019546|GO:0004585|GO:0019547
PubMed:  27109103

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 1-335 0e+00

ornithine carbamoyltransferase; Validated


:

Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 684.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   1 MAFNMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDP 80
Cdd:PRK02102   1 MAFNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  81 NSSQIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSdKPLHDISYA 160
Cdd:PRK02102  81 NDSQLGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHF-GPLKGLKLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 161 YLGDARNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEP 240
Cdd:PRK02102 160 YVGDGRNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGEE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 241 VEaWGERIKELLPYQVNMEIMKATGNPRAKFMHCLPAFHNSETKVGKQIAEQYPnlANGIEVTEDVFESPYNIAFEQAEN 320
Cdd:PRK02102 240 DE-WEERIKLLKPYQVNMDLMKATGNPDVIFMHCLPAFHDTETKVGKEIAEKYG--LKGLEVTDEVFESKYSIVFDEAEN 316

                        330
                 ....*....|....*
gi 489190666 321 RMHTIKAILVSTLAD 335
Cdd:PRK02102 317 RMHTIKAVMVATLGD 331
 
Name Accession Description Interval E-value
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 1-335 0e+00

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 684.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   1 MAFNMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDP 80
Cdd:PRK02102   1 MAFNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  81 NSSQIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSdKPLHDISYA 160
Cdd:PRK02102  81 NDSQLGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHF-GPLKGLKLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 161 YLGDARNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEP 240
Cdd:PRK02102 160 YVGDGRNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGEE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 241 VEaWGERIKELLPYQVNMEIMKATGNPRAKFMHCLPAFHNSETKVGKQIAEQYPnlANGIEVTEDVFESPYNIAFEQAEN 320
Cdd:PRK02102 240 DE-WEERIKLLKPYQVNMDLMKATGNPDVIFMHCLPAFHDTETKVGKEIAEKYG--LKGLEVTDEVFESKYSIVFDEAEN 316

                        330
                 ....*....|....*
gi 489190666 321 RMHTIKAILVSTLAD 335
Cdd:PRK02102 317 RMHTIKAVMVATLGD 331
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 3-335 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 525.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   3 FNMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNS 82
Cdd:COG0078    1 TNLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  83 SQIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSDKpLHDISYAYL 162
Cdd:COG0078   81 SQLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGK-LKGLKVAYV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 163 GDArNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEPVE 242
Cdd:COG0078  160 GDG-NNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 243 AwGERIKELLPYQVNMEIMKATGnPRAKFMHCLPAFHnsetkvgkqiaeqypnlanGIEVTEDVFESPYNIAFEQAENRM 322
Cdd:COG0078  239 A-EERIKAFKPYQVNEELMALAK-PDAIFMHCLPAHR-------------------GEEVTDEVIDGPQSVVFDEAENRL 297

                        330
                 ....*....|...
gi 489190666 323 HTIKAILVSTLAD 335
Cdd:COG0078  298 HAQKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 8-334 1.40e-169

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 473.38  E-value: 1.40e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666    8 RNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSSQIGH 87
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   88 KESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSDKpLHDISYAYLGDArN 167
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGK-LKGVKVVYVGDG-N 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  168 NMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEPvEAWGER 247
Cdd:TIGR00658 159 NVCNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEE-DKKEER 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  248 IKELLPYQVNMEIMKATgNPRAKFMHCLPAFHnsetkvgkqiaeqypnlanGIEVTEDVFESPYNIAFEQAENRMHTIKA 327
Cdd:TIGR00658 238 LKLFRPYQVNEELMELA-KPEVIFMHCLPAHR-------------------GEEVTDEVIEGPHSIVFDQAENRLHAQKA 297


                  ....*..
gi 489190666  328 ILVSTLA 334
Cdd:TIGR00658 298 VMVALLG 304
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
9-148 6.00e-69

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 211.90  E-value: 6.00e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666    9 NLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSSQIGHK 88
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   89 ESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMRE 148
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
 
Name Accession Description Interval E-value
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 1-335 0e+00

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 684.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   1 MAFNMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDP 80
Cdd:PRK02102   1 MAFNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  81 NSSQIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSdKPLHDISYA 160
Cdd:PRK02102  81 NDSQLGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHF-GPLKGLKLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 161 YLGDARNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEP 240
Cdd:PRK02102 160 YVGDGRNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGEE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 241 VEaWGERIKELLPYQVNMEIMKATGNPRAKFMHCLPAFHNSETKVGKQIAEQYPnlANGIEVTEDVFESPYNIAFEQAEN 320
Cdd:PRK02102 240 DE-WEERIKLLKPYQVNMDLMKATGNPDVIFMHCLPAFHDTETKVGKEIAEKYG--LKGLEVTDEVFESKYSIVFDEAEN 316

                        330
                 ....*....|....*
gi 489190666 321 RMHTIKAILVSTLAD 335
Cdd:PRK02102 317 RMHTIKAVMVATLGD 331
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 1-334 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 675.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   1 MAFNMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDP 80
Cdd:PRK01713   1 MAFNLKNRHLLSLVNHTEREIKYLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  81 NSSQIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSDKPLHDISYA 160
Cdd:PRK01713  81 NSSQIGHKESMKDTARVLGRMYDAIEYRGFKQSIVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENCDKPLSEISYV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 161 YLGDARNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEP 240
Cdd:PRK01713 161 YIGDARNNMGNSLLLIGAKLGMDVRICAPKALLPEASLVEMCEKFAKESGARITVTDDIDKAVKGVDFVHTDVWVSMGEP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 241 VEAWGERIKELLPYQVNMEIMKATGNPRAKFMHCLPAFHNSETKVGKQIAEQYPNLANGIEVTEDVFESPYNIAFEQAEN 320
Cdd:PRK01713 241 LETWGERIKLLMPYQVTPELMKRTGNPKVKFMHCLPAFHNSETKVGRQIAEKYPELANGIEVTEDVFESPMNIAFEQAEN 320

                        330
                 ....*....|....
gi 489190666 321 RMHTIKAILVSTLA 334
Cdd:PRK01713 321 RMHTIKAVMVASLA 334
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 4-334 0e+00

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 567.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   4 NMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSS 83
Cdd:PRK03515   3 QFYQRHFLRLLDFTPAELNSLLQLAAKLKADKKNGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  84 QIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREH-SDKPLHDISYAYL 162
Cdd:PRK03515  83 QIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHlPGKAFNEMTLAYA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 163 GDARNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEPVE 242
Cdd:PRK03515 163 GDARNNMGNSLLEAAALTGLDLRLVAPKACWPEAALVTECRALAQKNGGNITLTEDIAEGVKGADFIYTDVWVSMGEPKE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 243 AWGERIKELLPYQVNMEIMKATGNPRAKFMHCLPAFHNSETKVGKQIAEQYpNLANGIEVTEDVFESPYNIAFEQAENRM 322
Cdd:PRK03515 243 VWAERIALLRPYQVNSKMMQLTGNPQVKFLHCLPAFHDDQTTLGKKMAEEY-GLHGGMEVTDEVFESAHSIVFDQAENRL 321

                        330
                 ....*....|..
gi 489190666 323 HTIKAILVSTLA 334
Cdd:PRK03515 322 HTIKAVMVATLS 333
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 2-335 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 538.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   2 AFNMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPN 81
Cdd:PRK04284   1 MKNLRNRSFLTLLDFTPKEIEYLLDLSEDLKRAKYAGIEVQKLKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVTYLGPT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  82 SSQIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSDKPLHDISYAY 161
Cdd:PRK04284  81 GSQMGKKESTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEHLKKPYKDIKFTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 162 LGDARNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEPV 241
Cdd:PRK04284 161 VGDGRNNVANALMQGAAIMGMDFHLVCPKELNPDDELLNKCKEIAAETGGKITITDDIDEGVKGSDVIYTDVWVSMGEPD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 242 EAWGERIKELLPYQVNMEIMKATGNPRAKFMHCLPAFHNSETKVGKQIAEQYPnlANGIEVTEDVFESPYNIAFEQAENR 321
Cdd:PRK04284 241 EVWEERIKLLKPYQVNKEMMKKTGNPNAIFEHCLPSFHDLDTKVGKEIFEKYG--LKEMEVTDEVFESKASVVFDEAENR 318

                        330
                 ....*....|....
gi 489190666 322 MHTIKAILVSTLAD 335
Cdd:PRK04284 319 MHTIKAVMVATLGE 332
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 3-335 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 525.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   3 FNMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNS 82
Cdd:COG0078    1 TNLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  83 SQIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSDKpLHDISYAYL 162
Cdd:COG0078   81 SQLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGK-LKGLKVAYV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 163 GDArNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEPVE 242
Cdd:COG0078  160 GDG-NNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 243 AwGERIKELLPYQVNMEIMKATGnPRAKFMHCLPAFHnsetkvgkqiaeqypnlanGIEVTEDVFESPYNIAFEQAENRM 322
Cdd:COG0078  239 A-EERIKAFKPYQVNEELMALAK-PDAIFMHCLPAHR-------------------GEEVTDEVIDGPQSVVFDEAENRL 297

                        330
                 ....*....|...
gi 489190666 323 HTIKAILVSTLAD 335
Cdd:COG0078  298 HAQKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 8-334 1.40e-169

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 473.38  E-value: 1.40e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666    8 RNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSSQIGH 87
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   88 KESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSDKpLHDISYAYLGDArN 167
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGK-LKGVKVVYVGDG-N 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  168 NMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEPvEAWGER 247
Cdd:TIGR00658 159 NVCNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEE-DKKEER 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  248 IKELLPYQVNMEIMKATgNPRAKFMHCLPAFHnsetkvgkqiaeqypnlanGIEVTEDVFESPYNIAFEQAENRMHTIKA 327
Cdd:TIGR00658 238 LKLFRPYQVNEELMELA-KPEVIFMHCLPAHR-------------------GEEVTDEVIEGPHSIVFDQAENRLHAQKA 297


                  ....*..
gi 489190666  328 ILVSTLA 334
Cdd:TIGR00658 298 VMVALLG 304
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 4-334 5.56e-160

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 450.28  E-value: 5.56e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   4 NMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSS 83
Cdd:PRK12562   3 GFYKKHFLKLLDFTPAELNSLLQLAAKLKADKKNGKEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  84 QIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREH-SDKPLHDISYAYL 162
Cdd:PRK12562  83 QIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHlPGKAFNEMTLVYA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 163 GDARNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEPVE 242
Cdd:PRK12562 163 GDARNNMGNSMLEAAALTGLDLRLVAPQACWPEASLVAECSALAQKHGGKITLTEDIAAGVKGADFIYTDVWVSMGEPKE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 243 AWGERIKELLPYQVNMEIMKATGNPRAKFMHCLPAFHNSETKVGKQIAEQYpNLANGIEVTEDVFESPYNIAFEQAENRM 322
Cdd:PRK12562 243 KWAERIALLRGYQVNSKMMALTGNPQVKFLHCLPAFHDDQTTLGKKMAKEF-GLHGGMEVTDEVFESPASIVFDQAENRM 321

                        330
                 ....*....|..
gi 489190666 323 HTIKAILVSTLA 334
Cdd:PRK12562 322 HTIKAVMVATLA 333
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 4-333 5.40e-141

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 401.01  E-value: 5.40e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   4 NMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSS 83
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  84 QIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSdKPLHDISYAYLG 163
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHR-GSLKGLKVAWVG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 164 DArNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAqckKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEPVEA 243
Cdd:PRK00779 160 DG-NNVANSLLLAAALLGFDLRVATPKGYEPDPEIVE---KIAKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEA 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 244 wGERIKELLPYQVNMEIMKATgNPRAKFMHCLPAfHNSEtkvgkqiaeqypnlangiEVTEDVFESPYNIAFEQAENRMH 323
Cdd:PRK00779 236 -EERLKAFAPYQVNEELMALA-KPDAIFMHCLPA-HRGE------------------EVTDEVIDGPQSVVWDEAENRLH 294

                        330
                 ....*....|
gi 489190666 324 TIKAILVSTL 333
Cdd:PRK00779 295 AQKALLAWLL 304
putr_carbamoyl TIGR04384
putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase ...
 17-330 2.09e-98

putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase (EC 2.1.3.6). There is some overlapping specificity with ornithine carbamoyltransferase (EC 2.1.3.3). The gene regularly is found next to agmatine deiminase and a carbamate kinase, suggesting a conserved catabolic agmatine deiminase pathway. [Energy metabolism, Amino acids and amines]


Pssm-ID: 275177  Cd Length: 330  Bit Score: 293.86  E-value: 2.09e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   17 STRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSSQIGHKESMKDTAR 96
Cdd:TIGR04384   9 TKEEILDIIDLSLKIKEAIKDGYYPPLLKNKSLGMIFEQSSTRTRVSFETAMTQLGGHAQYLAPGQIQLGGHESIEDTAR 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   97 VLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREH--SDKPLHDISYAYLGDArNNMGNSLL 174
Cdd:TIGR04384  89 VLSRLVDIIMARVDRHETVVELAKYATVPVINGMSDYNHPTQELGDLFTMIEHlpAGKKLEDCKVVFVGDA-TQVCVSLM 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  175 LIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMGEPVEAWGERIKELLP- 253
Cdd:TIGR04384 168 FICTKMGMDFVHFGPKGYQIPEEWLAIAEANCKVSGGSVTVTDDVDEAVKGADFIYTDVWYGLYDQELSEEERMAIFYPk 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489190666  254 YQVNMEIMkATGNPRAKFMHCLPAfhnsetkvgkqiaeqypnlANGIEVTEDVFESPYNIAFEQAENRMHTIKAILV 330
Cdd:TIGR04384 248 YQVNPELM-AKAGPHAKFMHCLPA-------------------SRGEEVTDEVMDSPQSICFDEAENRLTAIRALLV 304
PLN02342 PLN02342
ornithine carbamoyltransferase
 11-334 4.64e-93

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 280.91  E-value: 4.64e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  11 LSLMHHSTRELRYLLDLSRDLKRAKYTGTEQ-QHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSSQIGHKE 89
Cdd:PLN02342  49 LHIDDFDKEEILGLLDRAKEVKALLKSGDRSfQPFKGKSMAMIFTKPSMRTRVSFETGFFLLGGHALYLGPDDIQLGKRE 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  90 SMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSDKpLHDISYAYLGDArNNM 169
Cdd:PLN02342 129 ETRDIARVLSRYNDIIMARVFAHQDVLDLAEYSSVPVINGLTDYNHPCQIMADALTIIEHIGR-LEGTKVVYVGDG-NNI 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 170 GNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQckkfAEESG-AKLTLTEDPKEAVKGVDFVHTDVWVSMGEPVEAwGERI 248
Cdd:PLN02342 207 VHSWLLLAAVLPFHFVCACPKGYEPDAKTVEK----ARAAGiSKIEITNDPAEAVKGADVVYTDVWASMGQKEEA-EKRK 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 249 KELLPYQVNMEIMKATGnPRAKFMHCLPAfhnsetkvgkqiaeqypnlANGIEVTEDVFESPYNIAFEQAENRMHTIKAI 328
Cdd:PLN02342 282 KAFQGFQVNEALMKLAG-PQAYFMHCLPA-------------------ERGVEVTDGVMEAPNSIVFPQAENRMHAQNAI 341


                 ....*.
gi 489190666 329 LVSTLA 334
Cdd:PLN02342 342 MLHQLG 347
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 8-333 5.83e-82

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 250.76  E-value: 5.83e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   8 RNLLSLMHHSTRELRYLLDLSRDLKR--AKYtgteQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSSQI 85
Cdd:PRK14805   2 KHLLSIKELTQQQLLDLLALAKTIKAnpAEY----RQALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCLYLDQQNGAL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  86 GHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMREHSDKpLHDISYAYLGDA 165
Cdd:PRK14805  78 GKRESVADFAANLSCWADAIVARVFSHSTIEQLAEHGSVPVINALCDLYHPCQALADFLTLAEQFGD-VSKVKLAYVGDG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 166 rNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDpKEAVKGVDFVHTDVWVSMGEPVEAwg 245
Cdd:PRK14805 157 -NNVTHSLMYGAAILGATMTVICPPGHFPDGQIVAEAQELAAKSGGKLVLTSD-IEAIEGHDAIYTDTWISMGDDTPL-- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 246 ERIKE-LLPYQVNMEIMKATGnprAK-FMHCLPAFHnsetkvgkqiaeqypnlanGIEVTEDVFESPYNIAFEQAENRMH 323
Cdd:PRK14805 233 AEIKAkFAPYQVNKALMEKAG---ATfVMHCQPAHR-------------------GVEITSEVMDGEGSLILQQAENRMH 290

                        330
                 ....*....|
gi 489190666 324 TIKAILVSTL 333
Cdd:PRK14805 291 AQNAVLVTLL 300
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
9-148 6.00e-69

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 211.90  E-value: 6.00e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666    9 NLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSSQIGHK 88
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   89 ESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMRE 148
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
159-332 1.25e-68

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 211.70  E-value: 1.25e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  159 YAYLGDARNNMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVWVSMG 238
Cdd:pfam00185   2 IAYVGDGHNNVAHSLIIAAAKLGMDVRLATPKGYPPDPEVLDKAKKIAEKSGGSIEITDDPAEAVKGADVVYTDVWQSMG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  239 EPVEaWGERIKELLPYQVNMEIMKATGnPRAKFMHCLPAFHnsetkvgkqiaeqypnlanGIEVTEDVFESPYNIAFEQA 318
Cdd:pfam00185  82 QEKE-REERLKAFKPYQVNEELMKLAK-KDAIFMHCLPAHR-------------------GEEVTDDVFDGPRSVVFDQA 140

                         170
                  ....*....|....
gi 489190666  319 ENRMHTIKAILVST 332
Cdd:pfam00185 141 ENRLHAQKALLALL 154
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 5-329 3.11e-50

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 170.31  E-value: 3.11e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   5 MHNRNLLSLMHHSTRELRYLLDLSRDLKRakytGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSS- 83
Cdd:PRK04523   1 MSLKHFLNTQDWSRAELDALLTQAAAFKR----NKLGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVLQPGKDa 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  84 -QIGHK----------ESMKDTARVLGRMYDAIEYRGF---------KQEIV-EELAKFAGVPVFNgLTDEYHPTQMLAD 142
Cdd:PRK04523  77 wPIEFElgavmdgeteEHIREVARVLSRYVDLIGVRAFpkfvdwskdRQDQVlNSFAKYSTVPVIN-METITHPCQELAH 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 143 VLTMREHSDKPLHD----ISYAY----LGDArnnMGNSLLLIGAKLGMDVRIAAPKALWPHDE-FVAQCKKFAEESGAKL 213
Cdd:PRK04523 156 ALALQEHFGTTLRGkkyvLTWTYhpkpLNTA---VANSALLIATRLGMDVTLLCPTPDYILDErYMDWAEQNAAESGGSL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 214 TLTEDPKEAVKGVDFVHTDVWVSMgePV-EAWGERiKELLP----YQVNMEIMKATGNprAKFMHCLPAFHNsetkvgkq 288
Cdd:PRK04523 233 TVSHDIDSAYAGADVVYAKSWGAL--PFfGNWEPE-KPIRDqyqhFIVDERKMALTNN--GVFSHCLPLRRN-------- 299

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 489190666 289 iaeqypnlangIEVTEDVFESPYNIAFEQAENRMHTIKAIL 329
Cdd:PRK04523 300 -----------VKVTDAVMDSPNCIAIDEAENRLHVQKAIM 329
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 8-333 5.22e-46

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 158.65  E-value: 5.22e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   8 RNLLSLMHHSTRELRYLLDLSRDLK--RAKYTGteqqHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSSQI 85
Cdd:PRK14804   7 KHLISWEDWSDSEILDLLDFAVHVKknRVNYAG----HMSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDWMASNF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  86 gHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNGLTDEYHPTQMLADVLTMR-EHSDKPLHDISYAYLGd 164
Cdd:PRK14804  83 -QLSDIDLEARYLSRNVSVIMARLKKHEDLLVMKNGSQVPVINGCDNMFHPCQSLADIMTIAlDSPEIPLNQKQLTYIG- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 165 ARNNMGNSLLLIGAKLGMDVRIAAPKAlwPHDEFVAQCKKFAEESGAkLTLTEDPKEAVKGVDFVHTDVWVSM---GEP- 240
Cdd:PRK14804 161 VHNNVVNSLIGITAALGIHLTLVTPIA--AKENIHAQTVERAKKKGT-LSWEMNLHKAVSHADYVYTDTWLDMeffNDPs 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 241 -VEAWGERIKELLPYQVNMEIMKATgnpRAKFMHCLPafhnsetkvgkqiaeqypnLANGIEVTEDVFESPYNIAFEQAE 319
Cdd:PRK14804 238 yADKKKQRMELMMPYQINSSLMEKT---NAKVMHDMP-------------------IHAGYEITREVVLSDRSIIFQQAE 295

                        330
                 ....*....|....
gi 489190666 320 NRMHTIKAILVSTL 333
Cdd:PRK14804 296 NRLDAQKAVILKLL 309
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
3-329 6.44e-36

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 131.73  E-value: 6.44e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   3 FNMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQ-QHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDP- 80
Cdd:PRK00856   1 NPLKMKHLLSIEDLSREEIELLLDTAEEFKEVLRREVKKvPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAs 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  81 -NSSQIGhkESMKDTARVLGRMY-DAIEYRGFKQEIVEELAKFAGVPVFNGlTD---EyHPTQMLADVLTMREHSdKPLH 155
Cdd:PRK00856  81 tSSVSKG--ETLADTIRTLSAMGaDAIVIRHPQSGAARLLAESSDVPVINA-GDgshQ-HPTQALLDLLTIREEF-GRLE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 156 DISYAYLGD------ARNNMgnsLLLigAKLGMDVRIAAPKALWPHDefvaqckkFAEEsgaklTLTEDPKEAVKGVDFV 229
Cdd:PRK00856 156 GLKVAIVGDikhsrvARSNI---QAL--TRLGAEVRLIAPPTLLPEG--------MPEY-----GVHTDLDEVIEDADVV 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 230 ---------HTDvwvsmGEPVEAwgERIKELlpYQVNMEIMKATgNPRAKFMHCLPAFHnsetkvgkqiaeqypnlanGI 300
Cdd:PRK00856 218 mmlrvqkerMDG-----GLLPSY--EEYKRS--YGLTAERLALA-KPDAIVMHPGPVNR-------------------GV 268

                        330       340       350
                 ....*....|....*....|....*....|...
gi 489190666 301 EVTEDVFESPYNIAFEQAEN----RMhtikAIL 329
Cdd:PRK00856 269 EIASDVADGPQSVIFEQVTNgvavRM----AVL 297
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 4-335 1.11e-24

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 103.28  E-value: 1.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   4 NMHNRNLLSLMHHSTRELRYLLDLSRDLKrakytgteqqHLKRKNIAL----------IFEKTSTRTRCAFEVAAYDQGA 73
Cdd:PRK07200  17 HMHEKDFLLTWEKTPDELKAVLDVADALR----------ALREENISTkvfnsglgisVFRDNSTRTRFSYASACNLLGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  74 NVTYIDPNSSQIGHKESMKDTARVLGRMYDAIEYR---------------------GFKQEIVEELAKFAgvpvfNGLTD 132
Cdd:PRK07200  87 EVQDLDEGKSQIAHGETVRETANMISFMADVIGIRddmyigkgnaymrevgaavddGYKQGVLPQRPTLV-----NLQCD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 133 EYHPTQMLADVLTMREHsdkplhdisyayLGDARNNMGNSLL------------------LIG--AKLGMDVRIAAPKAL 192
Cdd:PRK07200 162 IDHPTQSMADLLHLIEH------------FGGLENLKGKKIAmtwayspsygkplsvpqgIIGlmTRFGMDVTLAHPEGY 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 193 WPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGVDFVHTDVW---VSMGEPVEAWGERI--------KELLP-------Y 254
Cdd:PRK07200 230 DLMPEVVEVAKKNAKASGGSFRQVNSMEEAFKDADIVYPKSWapyKVMEERTELYRAGDhegikaleKELLAqnaqhkdW 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 255 QVNMEIMKATGNPRAKFMHCLPA-FHNSETKVGkqiaeqypnlangiEVTEDVFESpYNIA-FEQAENRMHTIKA-ILVS 331
Cdd:PRK07200 310 HCTEEMMKLTKDGKALYMHCLPAdISGVSCKEG--------------EVTESVFDR-YRIAlYKEASWKPYIIAAmIFLR 374


                 ....
gi 489190666 332 TLAD 335
Cdd:PRK07200 375 KYKN 378
PLN02527 PLN02527
aspartate carbamoyltransferase
 9-329 7.44e-18

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 82.49  E-value: 7.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   9 NLLSLMHHSTRELRYLLDLSRDLKRAKYTGTEQQHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDP--NSSQIG 86
Cdd:PLN02527   2 DVIEAQQFDREMLELLFEVAREMEKVERGSPGSQMLKGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTENagEFSSAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  87 HKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFN-GLTDEYHPTQMLADVLTMREHSDKpLHDISYAYLGDA 165
Cdd:PLN02527  82 KGETLEDTIRTVEGYSDIIVLRHFESGAARRAAATAEIPVINaGDGPGQHPTQALLDVYTIQREIGR-LDGIKVGLVGDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 166 RNNMG-NSLLLIGAKL-GMDVRIAAPKALWPHDEFvaqcKKFAEESGAKLTLTEDPKEAVKGVDFVH-TDVwvsmgePVE 242
Cdd:PLN02527 161 ANGRTvRSLAYLLAKYeDVKIYFVAPDVVKMKDDI----KDYLTSKGVEWEESSDLMEVASKCDVLYqTRI------QRE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 243 AWGERIKELLP----YQVNMEIMKATgNPRAKFMHCLPAFHnsetkvgkqiaeqypnlangiEVTEDVFESPYNIAFEQA 318
Cdd:PLN02527 231 RFGERIDLYEAargkYIVDKKVMDVL-PKHAVVMHPLPRLD---------------------EITTDVDSDPRAAYFRQA 288

                        330
                 ....*....|.
gi 489190666 319 ENRMHTIKAIL 329
Cdd:PLN02527 289 KNGLFIRMALL 299
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 51-230 1.34e-12

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 67.44  E-value: 1.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  51 LIFEKtSTRTRCAFEVAAYDQGANVT-YIDPNSSQIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNG 129
Cdd:PRK08192  50 LFFEP-STRTRVSFGCAFNLLGGHVReTTGMASSSLSKGESLYDTARVLSTYSDVIAMRHPDAGSVKEFAEGSRVPVING 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 130 --LTDEyHPTQMLADVLTMR---EHSDKPLHDISYAYLGDARNnmGNSLLLIGAKLGM--DVRIA--APKALWPHDEFVA 200
Cdd:PRK08192 129 gdGSNE-HPTQALLDLFTIQkelAHAGRGIDGMHIAMVGDLKF--GRTVHSLSRLLCMykNVSFTlvSPKELAMPDYVIS 205

                        170       180       190
                 ....*....|....*....|....*....|
gi 489190666 201 QCkkfaEESGAKLTLTEDPKEAVKGVDFVH 230
Cdd:PRK08192 206 DI----ENAGHKITITDQLEGNLDKADILY 231
pyrB PRK13814
aspartate carbamoyltransferase;
27-207 8.70e-12

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 65.12  E-value: 8.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  27 LSRD-----LKRAKY---TGTEQ----QHLKRKNIALIFEKTSTRTRCAFEVAAYDQGANVTYIDPNSSQIGHKESMKDT 94
Cdd:PRK13814  14 LTRDhieklIQRANYfltQGMEKnsvfETLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVLNPNLKISAISKGETLFDT 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  95 ARVLGRM--YDAIeYRGFKQEIVEELAK--FAGVPVFNGLTDEYHPTQMLADVLTMREHsdKP-LHDISYAYLGDARNN- 168
Cdd:PRK13814  94 IKTLEAMgvYFFI-VRHSENETPEQIAKqlSSGVVINAGDGNHQHPSQALIDLMTIKQH--KPhWNKLCVTIIGDIRHSr 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 489190666 169 MGNSLLLIGAKLGM-DVRIAAPKALWPHDEFVAQCKKFAE 207
Cdd:PRK13814 171 VANSLMDGLVTMGVpEIRLVGPSSLLPDKVGNDSIKKFTE 210
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 51-276 3.47e-11

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 63.73  E-value: 3.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  51 LIFEkTSTRTRCAFEVAAYDQGANV-TYIDPNSSQIGHKESMKDTARVLGRMYDAIEYRGFKQEIVEELAKFAGVPVFNG 129
Cdd:PRK11891 132 LFFE-ASTRTRVSFGAAFCRLGGSVcDTTGFTFSSMAKGESIYDTSRVMSGYVDALVIRHPEQGSVAEFARATNLPVING 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666 130 LTDE-YHPTQMLADVLTM-REHS--DKPLHDISYAYLGDARNNMG-NSLL-LIGAKLGMDVRIAAPKALWPHDEFVAQck 203
Cdd:PRK11891 211 GDGPgEHPSQALLDLYTIqREFSrlGKIVDGAHIALVGDLKYGRTvHSLVkLLALYRGLKFTLVSPPTLEMPAYIVEQ-- 288

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489190666 204 kfAEESGAKLTLTEDPKEAVKGVDFVHTdvwvsmgepVEAWGERIKELL------PYQVNMEIMKATGNPRAKFMHCLP 276
Cdd:PRK11891 289 --ISRNGHVIEQTDDLAAGLRGADVVYA---------TRIQKERFADESfegytpDFQINQALVDAVCKPDTLIMHPLP 356
pyrB PRK13376
bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase ...
 1-164 1.12e-04

bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional


Pssm-ID: 237369 [Multi-domain]  Cd Length: 525  Bit Score: 43.60  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666   1 MAFNMHNRNLLSLMHHSTRELRYLLDLSRDLKRAKYTGTE--QQHLKRKN--IALIFEKTSTRTRCAFEVAA-YDQGANV 75
Cdd:PRK13376   1 MKRDFLGRTLAVIEDLSVEEQLFLYEKTRELKQRWYEGEDvsEFRIKKRDvgIYIVFVEPSTRTKESFINAAkFHKNVKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489190666  76 TYIDPNSSQIGHKESMKDTARVLgrmydaIEYRGFKQEIV------------EELAKFAG-----VPVFNGLTD--EYHP 136
Cdd:PRK13376  81 NIFDSEHSSFNKQESYTDTFNML------TGYSDYSIFIVrtrlegvcrlleEKVSEFASrngieVPAFINAGDgkHEHP 154

                        170       180
                 ....*....|....*....|....*...
gi 489190666 137 TQMLADVLTMREHSDKPLHDISYAYLGD 164
Cdd:PRK13376 155 TQELLDEFTFLEQNNFDNSFIHIALVGD 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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