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Conserved domains on  [gi|489191210|ref|WP_003100569|]
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MULTISPECIES: hypothetical protein [Pseudomonas]

Protein Classification

SRPBCC family protein( domain architecture ID 51693)

SRPBCC (START/RHOalphaC/PITP/Bet v1/CoxG/CalC) family protein may have a deep hydrophobic ligand-binding pocket

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRPBCC super family cl44048
Ligand-binding SRPBCC domain [General function prediction only];
5-156 2.44e-11

Ligand-binding SRPBCC domain [General function prediction only];


The actual alignment was detected with superfamily member COG4276:

Pssm-ID: 443417  Cd Length: 153  Bit Score: 57.95  E-value: 2.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489191210   5 LHFESRLQASPEQLWRWITSVDGILReirpllsmSVPPGirslEDLEVVPRRP--LF---RSHMRL-FGLLPLG-TSQLT 77
Cdd:COG4276    4 FERETRIPAPLEEVFDFHSRPDNLER--------LTPPW----MGERILSGVPggLElgdRVTYRLrHFGIPQRwTSEIT 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489191210  78 llELTPGHGFIEQSPMTGMRLWRHERRILPTPGEageCLLVDQLTVRP-------LFAAGLVRWFLTRIFRHRHRVLCRQ 150
Cdd:COG4276   72 --EVEPPHYFVDEQVKGPFKSWRHEHRFEEVGGG---TLMTDRVEYELplgllgrLAHGLFVKKYLERIFAYRHRVLKEL 146


                 ....*.
gi 489191210 151 FRTDRR 156
Cdd:COG4276  147 LESHAK 152
 
Name Accession Description Interval E-value
SRPBCC COG4276
Ligand-binding SRPBCC domain [General function prediction only];
5-156 2.44e-11

Ligand-binding SRPBCC domain [General function prediction only];


Pssm-ID: 443417  Cd Length: 153  Bit Score: 57.95  E-value: 2.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489191210   5 LHFESRLQASPEQLWRWITSVDGILReirpllsmSVPPGirslEDLEVVPRRP--LF---RSHMRL-FGLLPLG-TSQLT 77
Cdd:COG4276    4 FERETRIPAPLEEVFDFHSRPDNLER--------LTPPW----MGERILSGVPggLElgdRVTYRLrHFGIPQRwTSEIT 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489191210  78 llELTPGHGFIEQSPMTGMRLWRHERRILPTPGEageCLLVDQLTVRP-------LFAAGLVRWFLTRIFRHRHRVLCRQ 150
Cdd:COG4276   72 --EVEPPHYFVDEQVKGPFKSWRHEHRFEEVGGG---TLMTDRVEYELplgllgrLAHGLFVKKYLERIFAYRHRVLKEL 146


                 ....*.
gi 489191210 151 FRTDRR 156
Cdd:COG4276  147 LESHAK 152
SRPBCC_3 cd07820
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized ...
 5-144 6.60e-06

Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.


Pssm-ID: 176862  Cd Length: 137  Bit Score: 43.36  E-value: 6.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489191210   5 LHFESRLQASPEQLWRWITSVDGILREIRPLLSMSV--PPGIRSLEDLEVVPRrplfrshMRLFGLLPLGTSQLTLLElt 82
Cdd:cd07820    1 LERSTVIPAPIEEVFDFHSRPDNLERLTPPWLEFAVlgRTPGLIYGGARVTYR-------LRHFGIPQRWTTEITEVE-- 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489191210  83 PGHGFI-EQS--PMtgmRLWRHERRILPTPGEageCLLVDQLTVRP-------LFAAGLVRWFLTRIFRHRH 144
Cdd:cd07820   72 PPRRFVdEQVsgPF---RSWRHTHRFEAIGGG---TLMTDRVEYRLplgplgrLAAPLVVRRYLERFFAYRH 137
 
Name Accession Description Interval E-value
SRPBCC COG4276
Ligand-binding SRPBCC domain [General function prediction only];
5-156 2.44e-11

Ligand-binding SRPBCC domain [General function prediction only];


Pssm-ID: 443417  Cd Length: 153  Bit Score: 57.95  E-value: 2.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489191210   5 LHFESRLQASPEQLWRWITSVDGILReirpllsmSVPPGirslEDLEVVPRRP--LF---RSHMRL-FGLLPLG-TSQLT 77
Cdd:COG4276    4 FERETRIPAPLEEVFDFHSRPDNLER--------LTPPW----MGERILSGVPggLElgdRVTYRLrHFGIPQRwTSEIT 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489191210  78 llELTPGHGFIEQSPMTGMRLWRHERRILPTPGEageCLLVDQLTVRP-------LFAAGLVRWFLTRIFRHRHRVLCRQ 150
Cdd:COG4276   72 --EVEPPHYFVDEQVKGPFKSWRHEHRFEEVGGG---TLMTDRVEYELplgllgrLAHGLFVKKYLERIFAYRHRVLKEL 146


                 ....*.
gi 489191210 151 FRTDRR 156
Cdd:COG4276  147 LESHAK 152
SRPBCC_3 cd07820
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized ...
 5-144 6.60e-06

Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.


Pssm-ID: 176862  Cd Length: 137  Bit Score: 43.36  E-value: 6.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489191210   5 LHFESRLQASPEQLWRWITSVDGILREIRPLLSMSV--PPGIRSLEDLEVVPRrplfrshMRLFGLLPLGTSQLTLLElt 82
Cdd:cd07820    1 LERSTVIPAPIEEVFDFHSRPDNLERLTPPWLEFAVlgRTPGLIYGGARVTYR-------LRHFGIPQRWTTEITEVE-- 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489191210  83 PGHGFI-EQS--PMtgmRLWRHERRILPTPGEageCLLVDQLTVRP-------LFAAGLVRWFLTRIFRHRH 144
Cdd:cd07820   72 PPRRFVdEQVsgPF---RSWRHTHRFEAIGGG---TLMTDRVEYRLplgplgrLAAPLVVRRYLERFFAYRH 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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