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Conserved domains on  [gi|489193260|ref|WP_003102595|]
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MULTISPECIES: Tfp pilus assembly protein FimT/FimU [Pseudomonas]

Protein Classification

GspH/FimT family pseudopilin( domain architecture ID 18794731)

GspH/FimT family pseudopilin may assemble either into the base or the tip of pili, and may function as an initiator or regulator of pilus biogenesis and dynamics

Gene Ontology:  GO:0015627|GO:0015628
SCOP:  4005454

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
4-71 5.83e-17

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


:

Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 71.03  E-value: 5.83e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489193260   4 RSQRALTLTELLFALVLLGILGSLALPGMAAWLDGNRERSVLHELSASIQLGRTHAVAYQRPVTLCPS 71
Cdd:COG4970    6 RRQRGFTLIELLVVLAILAILAAIAVPSFSSLIARQRLRAAANELAAALRLARSEAIRRGQPVTLSPS 73
GspH pfam12019
Type II transport protein GspH; GspH is involved in bacterial type II export systems. Like all ...
 47-148 1.81e-10

Type II transport protein GspH; GspH is involved in bacterial type II export systems. Like all pilins, GspH has an N terminus alpha helix. This helix is followed by nine beta strands forming two beta sheets, one of five antiparallel strands and one of four antiparallel strands. GspH is a minor pseudopilin; it is expressed much less than other pseudopilins in the type II secretion pilus (major pilins). The function and localization of minor pseudo-pilins are still to be fully unraveled. It has been suggested that some minor pseudopilins may assemble either into the base or the tip of pili, or both. They function as initiators or regulators of pilus biogenesis and dynamics, and/or as adaptors between various pseudopilin component and other members of the T2SS.


:

Pssm-ID: 463433  Cd Length: 108  Bit Score: 55.29  E-value: 1.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489193260   47 ELSASIQLGRTHAVAYQRPVTLCPstdgrhcgSDWGEGWLLAEDGGER---------LLVGRALAKKERLRWNRS--NRL 115
Cdd:pfam12019   4 RLAAALQLARSEAIKRGRPVTVCP--------SDWSGGWIVFVDANANgdldggedlLRVGAALAGGDVLVTASSasPQI 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 489193260  116 RFLPSGqLNIHNGRFLLC-GRHTVAWQLILNRQG 148
Cdd:pfam12019  76 TFNPDG-RAATPGTLTLCsGGSGRSRRVVVSASG 108
 
Name Accession Description Interval E-value
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
4-71 5.83e-17

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 71.03  E-value: 5.83e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489193260   4 RSQRALTLTELLFALVLLGILGSLALPGMAAWLDGNRERSVLHELSASIQLGRTHAVAYQRPVTLCPS 71
Cdd:COG4970    6 RRQRGFTLIELLVVLAILAILAAIAVPSFSSLIARQRLRAAANELAAALRLARSEAIRRGQPVTLSPS 73
GspH pfam12019
Type II transport protein GspH; GspH is involved in bacterial type II export systems. Like all ...
 47-148 1.81e-10

Type II transport protein GspH; GspH is involved in bacterial type II export systems. Like all pilins, GspH has an N terminus alpha helix. This helix is followed by nine beta strands forming two beta sheets, one of five antiparallel strands and one of four antiparallel strands. GspH is a minor pseudopilin; it is expressed much less than other pseudopilins in the type II secretion pilus (major pilins). The function and localization of minor pseudo-pilins are still to be fully unraveled. It has been suggested that some minor pseudopilins may assemble either into the base or the tip of pili, or both. They function as initiators or regulators of pilus biogenesis and dynamics, and/or as adaptors between various pseudopilin component and other members of the T2SS.


Pssm-ID: 463433  Cd Length: 108  Bit Score: 55.29  E-value: 1.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489193260   47 ELSASIQLGRTHAVAYQRPVTLCPstdgrhcgSDWGEGWLLAEDGGER---------LLVGRALAKKERLRWNRS--NRL 115
Cdd:pfam12019   4 RLAAALQLARSEAIKRGRPVTVCP--------SDWSGGWIVFVDANANgdldggedlLRVGAALAGGDVLVTASSasPQI 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 489193260  116 RFLPSGqLNIHNGRFLLC-GRHTVAWQLILNRQG 148
Cdd:pfam12019  76 TFNPDG-RAATPGTLTLCsGGSGRSRRVVVSASG 108
typeII_sec_gspH TIGR01708
type II secretion system protein H; This model represents GspH, protein H of the main terminal ...
 4-153 1.78e-04

type II secretion system protein H; This model represents GspH, protein H of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130769 [Multi-domain]  Cd Length: 143  Bit Score: 39.47  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489193260    4 RSQRALTLTELLFALVLLGILGSLALPGMAAwLDGNRE-RSVLHELSASIQLGRTHAVAYQRPVTLCPSTDGRHCGSDWG 82
Cdd:TIGR01708   1 HRQSGFTLIELLVVLAIMGLVAAAAALSLVS-HYGTKSlDQVAGRLAARLRLAQTSARATGRPVLLRLGSRGIRFGERAS 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489193260   83 EGWLLAEdggerlLVGRALAKKERLRWNRSNRLR--FLPSGQLNIHNGRfLLCGRHTVAWQliLNRQGRLRTA 153
Cdd:TIGR01708  80 LALPVDE------VKMTDWTGQETVVADRQTVLTvlFLPDGRASPMDMT-LQRKGRSVTVA--VNWLGGLRLW 143
 
Name Accession Description Interval E-value
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
4-71 5.83e-17

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 71.03  E-value: 5.83e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489193260   4 RSQRALTLTELLFALVLLGILGSLALPGMAAWLDGNRERSVLHELSASIQLGRTHAVAYQRPVTLCPS 71
Cdd:COG4970    6 RRQRGFTLIELLVVLAILAILAAIAVPSFSSLIARQRLRAAANELAAALRLARSEAIRRGQPVTLSPS 73
GspH pfam12019
Type II transport protein GspH; GspH is involved in bacterial type II export systems. Like all ...
 47-148 1.81e-10

Type II transport protein GspH; GspH is involved in bacterial type II export systems. Like all pilins, GspH has an N terminus alpha helix. This helix is followed by nine beta strands forming two beta sheets, one of five antiparallel strands and one of four antiparallel strands. GspH is a minor pseudopilin; it is expressed much less than other pseudopilins in the type II secretion pilus (major pilins). The function and localization of minor pseudo-pilins are still to be fully unraveled. It has been suggested that some minor pseudopilins may assemble either into the base or the tip of pili, or both. They function as initiators or regulators of pilus biogenesis and dynamics, and/or as adaptors between various pseudopilin component and other members of the T2SS.


Pssm-ID: 463433  Cd Length: 108  Bit Score: 55.29  E-value: 1.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489193260   47 ELSASIQLGRTHAVAYQRPVTLCPstdgrhcgSDWGEGWLLAEDGGER---------LLVGRALAKKERLRWNRS--NRL 115
Cdd:pfam12019   4 RLAAALQLARSEAIKRGRPVTVCP--------SDWSGGWIVFVDANANgdldggedlLRVGAALAGGDVLVTASSasPQI 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 489193260  116 RFLPSGqLNIHNGRFLLC-GRHTVAWQLILNRQG 148
Cdd:pfam12019  76 TFNPDG-RAATPGTLTLCsGGSGRSRRVVVSASG 108
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 4-50 7.86e-07

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 45.29  E-value: 7.86e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 489193260   4 RSQRALTLTELLFALVLLGILGSLALPGMAAWLDGNRERSVLHELSA 50
Cdd:COG2165    8 RRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQ 54
typeII_sec_gspH TIGR01708
type II secretion system protein H; This model represents GspH, protein H of the main terminal ...
 4-153 1.78e-04

type II secretion system protein H; This model represents GspH, protein H of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130769 [Multi-domain]  Cd Length: 143  Bit Score: 39.47  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489193260    4 RSQRALTLTELLFALVLLGILGSLALPGMAAwLDGNRE-RSVLHELSASIQLGRTHAVAYQRPVTLCPSTDGRHCGSDWG 82
Cdd:TIGR01708   1 HRQSGFTLIELLVVLAIMGLVAAAAALSLVS-HYGTKSlDQVAGRLAARLRLAQTSARATGRPVLLRLGSRGIRFGERAS 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489193260   83 EGWLLAEdggerlLVGRALAKKERLRWNRSNRLR--FLPSGQLNIHNGRfLLCGRHTVAWQliLNRQGRLRTA 153
Cdd:TIGR01708  80 LALPVDE------VKMTDWTGQETVVADRQTVLTvlFLPDGRASPMDMT-LQRKGRSVTVA--VNWLGGLRLW 143
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
4-53 4.43e-03

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 35.44  E-value: 4.43e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489193260   4 RSQRALTLTELLFALVLLGILGSLALPGMAAWLDGNRE---RSVLHELSASIQ 53
Cdd:COG4968    7 RRQRGFTLIELMIVVAIIGILAAIAIPSYQDYVERARRaeaKAALLELAQAQE 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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