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Conserved domains on  [gi|489194165|ref|WP_003103491|]
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MULTISPECIES: NAD-glutamate dehydrogenase GdhB [Pseudomonas]

Protein Classification

NAD-glutamate dehydrogenase( domain architecture ID 11458462)

NAD-specific glutamate dehydrogenase is involved in arginine catabolism by converting L-glutamate into 2-oxoglutarate, which is then channeled into the tricarboxylic acid cycle; can also utilize other amino acids of the glutamate family

EC:  1.4.1.2
Gene Ontology:  GO:0004352
PubMed:  10924516

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gdh2 COG2902
NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism];
5-1610 0e+00

NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism];


:

Pssm-ID: 442147 [Multi-domain]  Cd Length: 1607  Bit Score: 2726.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165    5 TAASKADFQHQLQTALAQHLGDKALPQVTLFAEQFFSLISLDELTQRRLSDLVGCTLSAWRLLERFDRDQPEVRVYNPDY 84
Cdd:COG2902     3 SEASKAELLEAVAELIAERLPAAQAPLVAAFARQYYRHVPPEDLAARSPEDLYGAALSHWQLAQQRKPGEPKVRVFNPDL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   85 EKHGWQSTHTAVEVLHPDLPFLVDSVRMELNRRGYSIHTLQTNVLSVRRSAKGELKEILPKGSQGKDVSQESLMYLEIDR 164
Cdd:COG2902    83 EEHGWQSTHTVVEIVTDDMPFLVDSVTMELNRLGLTIHLVVHPVLAVERDADGELVEVLPADEAPADGLRESLIHIEIDR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  165 CAHAGELRALEKAILEVLGEVRVTVADFEPMKAKARELLTWLGKAKLKVPAEELKEVRSYLEWLLDNHFTFLGYEEFSVA 244
Cdd:COG2902   163 QTDPEALEELEAELERVLADVRAAVEDWPAMRARLLEIAAELEAAPPPVDADEVAEAAAFLRWLADDHFTFLGYREYDLV 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  245 DEADGGRMVYDEKSFLGLTRLLRAGLSKDDL-HIEDYAVAYLREPVLLSFAKAAHPSRVHRPAYPDYVSIRELDGKGRVI 323
Cdd:COG2902   243 GEDGDDVLRPVPGSGLGILRDDSVRVRGRSLsALPPEARAFAREPDLLILTKANSRSTVHRPAYLDYIGVKRFDADGEVI 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  324 RECRFMGLFTSSVYNESVNDIPFIRGKVAEVMRRSGFDTKAHLGKELAQVLEVLPRDDLFQTPVDELFSTALAIVRIQER 403
Cdd:COG2902   323 GERRFLGLFTSTAYNESVRDIPLLRRKVEAVLERSGFDPGSHSGKALLNILETYPRDELFQISEDELLETALGILHLQER 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  404 NKIRVFLRKDPYGRFCYCLAYVPRDVYSTETRLKIQQVLMERLQASDCEFWTFFSESVLARVQFILRVDPKSRIDIDPAR 483
Cdd:COG2902   403 RRVRLFLRRDPFGRFVSCLVYVPRDRYNTELRLRIQAILAEAFGGESVEFTTYFSESVLARVHFIVRVDPGELPDVDVAE 482

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  484 LEEEVIQACRSWQDDYSSLVVENLGEAKGTNVLADFPKGFPAGYRERFAPHFAVVDLQHLLSLSEQRPLVMSFYQPLAQG 563
Cdd:COG2902   483 LEARLAEAARSWEDDLREALVERFGEERGNRLARRYADAFPAGYREDFSPRTAVADIERLESLSEEGPLAMSLYRPLEAD 562

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  564 EQQLHCKLYHADTPLALSDVLPILENLGLRVLGEFPYRLRHQNGREYWIHDFAFTYAEGLDVDIQQLNEILQDAFVHIVS 643
Cdd:COG2902   563 PGELRLKLYHRGEPIPLSDVLPVLENMGLRVIDERPYEIEPADGEPVWIHDFGLEYPGGGEIDLDEVRELFEDAFAAVWR 642

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  644 GDAENDAFNRLVLTANLPWRDVALLRAYARYLKQIRLGFDLGYIASALNAHTDIARELVRLFKTRFYLARKltAEDLEDK 723
Cdd:COG2902   643 GEAENDGFNRLVLAAGLTWREVAVLRAYARYLRQIGFPFSQDYIEDTLARHPAIARLLVELFEARFDPARD--DDDREER 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  724 QQKLEQAILGALDEVQVLNEDRILRRYLDLIKATLRTNFYQPDGNGQNKSYFSFKFNPKAIPELPRPVPKYEIFVYSPRV 803
Cdd:COG2902   721 AAALREEIEAALDEVASLDEDRILRRFLNLIQATLRTNFYQRDADGQPKPYLSFKLDPRKIPDLPLPRPMFEIFVYSPRV 800

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  804 EGVHLRGGKVARGGLRWSDREEDFRTEVLGLVKAQQVKNAVIVPVGAKGGFVPRRLPLGGSRDEIQAEAIACYRIFISGL 883
Cdd:COG2902   801 EGVHLRGGKVARGGLRWSDRREDFRTEVLGLVKAQMVKNAVIVPVGAKGGFVVKRLPAPGDREAWLAEGIACYKTFIRGL 880

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  884 LDITDNLKEGEVVPPANVVRHDEDDPYLVVAADKGTATFSDIANGIAAEYGFWLGDAFASGGSAGYDHKGMGITAKGAWV 963
Cdd:COG2902   881 LDITDNLVGGEVVPPEDVVRHDGDDPYLVVAADKGTATFSDIANGISAEYGFWLGDAFASGGSVGYDHKKMGITARGAWE 960

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  964 SVQRHFRERGIDVQKDNISVIGIGDMAGDVFGNGLLMSDKLQLVAAFNHMHIFIDPNPDAASSFVERQRLFNLPRSSWAD 1043
Cdd:COG2902   961 SVKRHFRELGIDIQTEDFTVVGIGDMSGDVFGNGMLLSEHIRLVAAFDHRHIFIDPNPDAAASFAERKRLFELPRSSWAD 1040

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1044 YDAKLISAGGGIFLRSAKSIAITPEMKARFDIQADRLAPTELIHALLKAPVDLLWNGGIGTYVKSSKETHADVGDKANDG 1123
Cdd:COG2902  1041 YDKSLISKGGGVFSRSAKSIPLSPEMRAALGIEVDSLTPNELIRAILKAPVDLLWNGGIGTYVKASTESHADVGDRANDA 1120

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1124 LRVDGRELRAKVVGEGGNLGMTQLARVEFGLHGGANNTDFIDNAGGVDCSDHEVNIKILLNEVVQAGDMTEKQRNALLVK 1203
Cdd:COG2902  1121 LRVNGSELRAKVVGEGGNLGLTQLGRIEYALNGGRINTDAIDNSAGVDCSDHEVNIKILLNRLVADGDLTLKQRNKLLAE 1200

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1204 MTDAVGALVLGNNYKQTQALSLAQRRARERIAEYKRLMGDLEARGKLDRALEFLPSDEELAERISAGQGLTRAELSVLIS 1283
Cdd:COG2902  1201 MTDEVAELVLRDNYRQTQALSLAEAQAAERLGEHARFIRALERAGRLDRALEFLPSDEELAERRAAGQGLTRPELAVLLA 1280

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1284 YSKIDLKESLLKSLVPDDDYLTRDMETAFPALLAEKFGDAMRRHRLKREIVSTQIANDLVNHMGITFVQRLKESTGMSAA 1363
Cdd:COG2902  1281 YAKIVLKDELLASDLPDDPYLARELVRYFPKPLRERFADEIAEHPLRREIIATQLANDMVNRMGITFVFRLQEETGASAA 1360

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1364 NVAGAYVIVRDVFHLPHWFRQIENLDYQVPADIQLTLMDELMRLGRRATRWFLRSRRNELDAARDVAHFGPRIAALGLKL 1443
Cdd:COG2902  1361 DIARAYVIAREVFGLPALWAAIEALDNKVPADVQLEMLLEVRRLLRRATRWFLRNRRQPLDIAAVIERFRPGVAALRPAL 1440

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1444 NELLEGPTRELWQARYQTYVDAGVPELLARMVAGTSHLYTLLPIIEASDVTGQDTAEVAKAYFAVGSALDLTWYLQQITN 1523
Cdd:COG2902  1441 PELLPGEEREALEARAAELVEAGVPEDLARRIAALPYLYSALDIVEVAEETGRDVAEVARVYFALGDRLGLDWLREQISA 1520

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1524 LPVENNWQALAREAFRDDLDWQQRAITVSVLQMQDGPKEVEARVGLWLEQHLPLVERWRAMLVELRAASGTDYAMYAVAN 1603
Cdd:COG2902  1521 LPVDDRWQALARAALRDDLYAQQRALTAAVLRSTDPGEDAEERVEAWLEANAAALERWRQMLAEIRASGTLDLAMLSVAL 1600


                  ....*..
gi 489194165 1604 RELMDLA 1610
Cdd:COG2902  1601 RELRDLA 1607
 
Name Accession Description Interval E-value
Gdh2 COG2902
NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism];
5-1610 0e+00

NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism];


Pssm-ID: 442147 [Multi-domain]  Cd Length: 1607  Bit Score: 2726.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165    5 TAASKADFQHQLQTALAQHLGDKALPQVTLFAEQFFSLISLDELTQRRLSDLVGCTLSAWRLLERFDRDQPEVRVYNPDY 84
Cdd:COG2902     3 SEASKAELLEAVAELIAERLPAAQAPLVAAFARQYYRHVPPEDLAARSPEDLYGAALSHWQLAQQRKPGEPKVRVFNPDL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   85 EKHGWQSTHTAVEVLHPDLPFLVDSVRMELNRRGYSIHTLQTNVLSVRRSAKGELKEILPKGSQGKDVSQESLMYLEIDR 164
Cdd:COG2902    83 EEHGWQSTHTVVEIVTDDMPFLVDSVTMELNRLGLTIHLVVHPVLAVERDADGELVEVLPADEAPADGLRESLIHIEIDR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  165 CAHAGELRALEKAILEVLGEVRVTVADFEPMKAKARELLTWLGKAKLKVPAEELKEVRSYLEWLLDNHFTFLGYEEFSVA 244
Cdd:COG2902   163 QTDPEALEELEAELERVLADVRAAVEDWPAMRARLLEIAAELEAAPPPVDADEVAEAAAFLRWLADDHFTFLGYREYDLV 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  245 DEADGGRMVYDEKSFLGLTRLLRAGLSKDDL-HIEDYAVAYLREPVLLSFAKAAHPSRVHRPAYPDYVSIRELDGKGRVI 323
Cdd:COG2902   243 GEDGDDVLRPVPGSGLGILRDDSVRVRGRSLsALPPEARAFAREPDLLILTKANSRSTVHRPAYLDYIGVKRFDADGEVI 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  324 RECRFMGLFTSSVYNESVNDIPFIRGKVAEVMRRSGFDTKAHLGKELAQVLEVLPRDDLFQTPVDELFSTALAIVRIQER 403
Cdd:COG2902   323 GERRFLGLFTSTAYNESVRDIPLLRRKVEAVLERSGFDPGSHSGKALLNILETYPRDELFQISEDELLETALGILHLQER 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  404 NKIRVFLRKDPYGRFCYCLAYVPRDVYSTETRLKIQQVLMERLQASDCEFWTFFSESVLARVQFILRVDPKSRIDIDPAR 483
Cdd:COG2902   403 RRVRLFLRRDPFGRFVSCLVYVPRDRYNTELRLRIQAILAEAFGGESVEFTTYFSESVLARVHFIVRVDPGELPDVDVAE 482

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  484 LEEEVIQACRSWQDDYSSLVVENLGEAKGTNVLADFPKGFPAGYRERFAPHFAVVDLQHLLSLSEQRPLVMSFYQPLAQG 563
Cdd:COG2902   483 LEARLAEAARSWEDDLREALVERFGEERGNRLARRYADAFPAGYREDFSPRTAVADIERLESLSEEGPLAMSLYRPLEAD 562

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  564 EQQLHCKLYHADTPLALSDVLPILENLGLRVLGEFPYRLRHQNGREYWIHDFAFTYAEGLDVDIQQLNEILQDAFVHIVS 643
Cdd:COG2902   563 PGELRLKLYHRGEPIPLSDVLPVLENMGLRVIDERPYEIEPADGEPVWIHDFGLEYPGGGEIDLDEVRELFEDAFAAVWR 642

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  644 GDAENDAFNRLVLTANLPWRDVALLRAYARYLKQIRLGFDLGYIASALNAHTDIARELVRLFKTRFYLARKltAEDLEDK 723
Cdd:COG2902   643 GEAENDGFNRLVLAAGLTWREVAVLRAYARYLRQIGFPFSQDYIEDTLARHPAIARLLVELFEARFDPARD--DDDREER 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  724 QQKLEQAILGALDEVQVLNEDRILRRYLDLIKATLRTNFYQPDGNGQNKSYFSFKFNPKAIPELPRPVPKYEIFVYSPRV 803
Cdd:COG2902   721 AAALREEIEAALDEVASLDEDRILRRFLNLIQATLRTNFYQRDADGQPKPYLSFKLDPRKIPDLPLPRPMFEIFVYSPRV 800

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  804 EGVHLRGGKVARGGLRWSDREEDFRTEVLGLVKAQQVKNAVIVPVGAKGGFVPRRLPLGGSRDEIQAEAIACYRIFISGL 883
Cdd:COG2902   801 EGVHLRGGKVARGGLRWSDRREDFRTEVLGLVKAQMVKNAVIVPVGAKGGFVVKRLPAPGDREAWLAEGIACYKTFIRGL 880

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  884 LDITDNLKEGEVVPPANVVRHDEDDPYLVVAADKGTATFSDIANGIAAEYGFWLGDAFASGGSAGYDHKGMGITAKGAWV 963
Cdd:COG2902   881 LDITDNLVGGEVVPPEDVVRHDGDDPYLVVAADKGTATFSDIANGISAEYGFWLGDAFASGGSVGYDHKKMGITARGAWE 960

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  964 SVQRHFRERGIDVQKDNISVIGIGDMAGDVFGNGLLMSDKLQLVAAFNHMHIFIDPNPDAASSFVERQRLFNLPRSSWAD 1043
Cdd:COG2902   961 SVKRHFRELGIDIQTEDFTVVGIGDMSGDVFGNGMLLSEHIRLVAAFDHRHIFIDPNPDAAASFAERKRLFELPRSSWAD 1040

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1044 YDAKLISAGGGIFLRSAKSIAITPEMKARFDIQADRLAPTELIHALLKAPVDLLWNGGIGTYVKSSKETHADVGDKANDG 1123
Cdd:COG2902  1041 YDKSLISKGGGVFSRSAKSIPLSPEMRAALGIEVDSLTPNELIRAILKAPVDLLWNGGIGTYVKASTESHADVGDRANDA 1120

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1124 LRVDGRELRAKVVGEGGNLGMTQLARVEFGLHGGANNTDFIDNAGGVDCSDHEVNIKILLNEVVQAGDMTEKQRNALLVK 1203
Cdd:COG2902  1121 LRVNGSELRAKVVGEGGNLGLTQLGRIEYALNGGRINTDAIDNSAGVDCSDHEVNIKILLNRLVADGDLTLKQRNKLLAE 1200

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1204 MTDAVGALVLGNNYKQTQALSLAQRRARERIAEYKRLMGDLEARGKLDRALEFLPSDEELAERISAGQGLTRAELSVLIS 1283
Cdd:COG2902  1201 MTDEVAELVLRDNYRQTQALSLAEAQAAERLGEHARFIRALERAGRLDRALEFLPSDEELAERRAAGQGLTRPELAVLLA 1280

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1284 YSKIDLKESLLKSLVPDDDYLTRDMETAFPALLAEKFGDAMRRHRLKREIVSTQIANDLVNHMGITFVQRLKESTGMSAA 1363
Cdd:COG2902  1281 YAKIVLKDELLASDLPDDPYLARELVRYFPKPLRERFADEIAEHPLRREIIATQLANDMVNRMGITFVFRLQEETGASAA 1360

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1364 NVAGAYVIVRDVFHLPHWFRQIENLDYQVPADIQLTLMDELMRLGRRATRWFLRSRRNELDAARDVAHFGPRIAALGLKL 1443
Cdd:COG2902  1361 DIARAYVIAREVFGLPALWAAIEALDNKVPADVQLEMLLEVRRLLRRATRWFLRNRRQPLDIAAVIERFRPGVAALRPAL 1440

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1444 NELLEGPTRELWQARYQTYVDAGVPELLARMVAGTSHLYTLLPIIEASDVTGQDTAEVAKAYFAVGSALDLTWYLQQITN 1523
Cdd:COG2902  1441 PELLPGEEREALEARAAELVEAGVPEDLARRIAALPYLYSALDIVEVAEETGRDVAEVARVYFALGDRLGLDWLREQISA 1520

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1524 LPVENNWQALAREAFRDDLDWQQRAITVSVLQMQDGPKEVEARVGLWLEQHLPLVERWRAMLVELRAASGTDYAMYAVAN 1603
Cdd:COG2902  1521 LPVDDRWQALARAALRDDLYAQQRALTAAVLRSTDPGEDAEERVEAWLEANAAALERWRQMLAEIRASGTLDLAMLSVAL 1600


                  ....*..
gi 489194165 1604 RELMDLA 1610
Cdd:COG2902  1601 RELRDLA 1607
Bac_GDH pfam05088
Bacterial NAD-glutamate dehydrogenase; This family consists of several bacterial proteins ...
 77-1608 0e+00

Bacterial NAD-glutamate dehydrogenase; This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyze the reversible oxidative deamination of glutamate to ketoglutarate and ammonia.


Pssm-ID: 428297 [Multi-domain]  Cd Length: 1530  Bit Score: 2653.36  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165    77 VRVYNPDYEKHGWQSTHTAVEVLHPDLPFLVDSVRMELNRRGYSIHTLQTNVLSVRRSAKGELKEILPKGSQGKDVSQES 156
Cdd:pfam05088    1 VRVFNPDLEEHGWQSTHTVVEIVNDDMPFLVDSVTMELNRQGLTIHLVVHPVLVVRRDADGKLVEVLPAADAAAGAAGES 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   157 LMYLEIDRCAHAGELRALEKAILEVLGEVRVTVADFEPMKAKARELLTWLGKAKLKVPAEELKEVRSYLEWLLDNHFTFL 236
Cdd:pfam05088   81 LIHIEIDRQTDPERLEALEAELERVLADVRAAVEDWPAMRARLLAIAAELETAPPPVSADEVEEAAAFLRWLADDHFTFL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   237 GYEEFSVADEADGGRMVYDEKSFLGLTRLLRAGLSKDDL-HIEDYAVAYLREPVLLSFAKAAHPSRVHRPAYPDYVSIRE 315
Cdd:pfam05088  161 GYREYDLVEDEGGGVLRAVPGSGLGILRDDSVLPRSRSLaALPPEARAFALEPELLILTKANSRSTVHRPAYLDYVGVKR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   316 LDGKGRVIRECRFMGLFTSSVYNESVNDIPFIRGKVAEVMRRSGFDTKAHLGKELAQVLEVLPRDDLFQTPVDELFSTAL 395
Cdd:pfam05088  241 FDADGEVIGERRFLGLFTSTAYNESPREIPLLRRKVARVLERSGFDPGSHSGKALLNILETYPRDELFQISEDELLEIAL 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   396 AIVRIQERNKIRVFLRKDPYGRFCYCLAYVPRDVYSTETRLKIQQVLMERLQASDCEFWTFFSESVLARVQFILRVDPKS 475
Cdd:pfam05088  321 GILHLQERRRVRLFLRRDPFGRFVSCLVYVPRDRYNTELRLRIQAILAEALGGTDVEFTTYFSESVLARLHFIVRVDPGN 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   476 RIDIDPARLEEEVIQACRSWQDDYSSLVVENLGEAKGTNVLADFPKGFPAGYRERFAPHFAVVDLQHLLSLSEQRPLVMS 555
Cdd:pfam05088  401 PPEVDVAELEARLAEAARSWEDDLREALVEAHGEERGNRLARRYADAFPAAYKEDFSPRSAVADIERLEALSEEGDLAMS 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   556 FYQPLAQGEQQLHCKLYHADTPLALSDVLPILENLGLRVLGEFPYRLRHQNGREYWIHDFAFTYAEGLDVDIQQLNEILQ 635
Cdd:pfam05088  481 LYRPLEADPGELRLKLYRRGEPLPLSDVLPMLENMGLRVIDERPYEIRPADGKRVWIHDFGLRYAGGAALDLDEVRELFE 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   636 DAFVHIVSGDAENDAFNRLVLTANLPWRDVALLRAYARYLKQIRLGFDLGYIASALNAHTDIARELVRLFKTRFYLARkl 715
Cdd:pfam05088  561 DAFAAVWRGEAENDGFNRLVLRAGLTWREVAVLRAYARYLRQIGFTFSQDYIEDTLAAHPDIARLLVALFEARFDPAL-- 638

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   716 tAEDLEDKQQKLEQAILGALDEVQVLNEDRILRRYLDLIKATLRTNFYQPDGNGQNKSYFSFKFNPKAIPELPRPVPKYE 795
Cdd:pfam05088  639 -AAGREARAEALEAEILAALDEVASLDEDRILRRYLNLIEATLRTNFYQRDADGQPKPYISFKLDPRAIPDLPLPRPMFE 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   796 IFVYSPRVEGVHLRGGKVARGGLRWSDREEDFRTEVLGLVKAQQVKNAVIVPVGAKGGFVPRRLPLGGSRDEIQAEAIAC 875
Cdd:pfam05088  718 IFVYSPRVEGVHLRGGKVARGGLRWSDRREDFRTEVLGLVKAQMVKNAVIVPVGAKGGFVVKRLPPAGDREAWLAEGIAC 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   876 YRIFISGLLDITDNLKEGEVVPPANVVRHDEDDPYLVVAADKGTATFSDIANGIAAEYGFWLGDAFASGGSAGYDHKGMG 955
Cdd:pfam05088  798 YKTFIRGLLDITDNLVDGEVVPPADVVRHDGDDPYLVVAADKGTATFSDIANGISAEYGFWLGDAFASGGSVGYDHKKMG 877

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   956 ITAKGAWVSVQRHFRERGIDVQKDNISVIGIGDMAGDVFGNGLLMSDKLQLVAAFNHMHIFIDPNPDAASSFVERQRLFN 1035
Cdd:pfam05088  878 ITARGAWESVKRHFRELGVDTQTEDFTVVGIGDMSGDVFGNGMLLSEHIRLVAAFNHRHIFIDPDPDAAASFAERKRLFE 957

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1036 LPRSSWADYDAKLISAGGGIFLRSAKSIAITPEMKARFDIQADRLAPTELIHALLKAPVDLLWNGGIGTYVKSSKETHAD 1115
Cdd:pfam05088  958 LPRSSWADYDRSLISAGGGVFPRSAKSIPLSPEMRAALGIEKDVLTPNELIRAILKAPVDLLWNGGIGTYVKASTETHAD 1037

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1116 VGDKANDGLRVDGRELRAKVVGEGGNLGMTQLARVEFGLHGGANNTDFIDNAGGVDCSDHEVNIKILLNEVVQAGDMTEK 1195
Cdd:pfam05088 1038 VGDKANDALRVNGSELRAKVVGEGGNLGLTQLGRIEYALNGGRINTDAIDNSAGVDCSDHEVNIKILLNGVVAAGDLTLK 1117

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1196 QRNALLVKMTDAVGALVLGNNYKQTQALSLAQRRARERIAEYKRLMGDLEARGKLDRALEFLPSDEELAERISAGQGLTR 1275
Cdd:pfam05088 1118 QRNALLAEMTDEVAELVLRDNYRQTQALSLAEAQAAERLDEHARLIRALEREGRLDRALEFLPSDEELAERKAAGQGLTR 1197

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1276 AELSVLISYSKIDLKESLLKSLVPDDDYLTRDMETAFPALLAEKFGDAMRRHRLKREIVSTQIANDLVNHMGITFVQRLK 1355
Cdd:pfam05088 1198 PELAVLLAYAKIVLKDELLASDLPDDPYLARELVRYFPTPLRERFAEAIARHPLRREIIATQLANDMVNRMGITFVFRLQ 1277

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1356 ESTGMSAANVAGAYVIVRDVFHLPHWFRQIENLDYQVPADIQLTLMDELMRLGRRATRWFLRSRRNELDAARDVAHFGPR 1435
Cdd:pfam05088 1278 EETGASVADVARAYVIAREVFGLPELWAQIEALDNKVPAAVQTEMLLEVRRLVRRATRWLLRNRRQPLDIAATIARFAPG 1357

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1436 IAALGLKLNELLEGPTRELWQARYQTYVDAGVPELLARMVAGTSHLYTLLPIIEASDVTGQDTAEVAKAYFAVGSALDLT 1515
Cdd:pfam05088 1358 VAALAAQLPELLPGAEREALQARAARLVEAGVPEELARRVAGLPYLYSALDIVEVAEATGRDLEEVARVYFALGDRLGLD 1437

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1516 WYLQQITNLPVENNWQALAREAFRDDLDWQQRAITVSVLQMQDGPKEVEARVGLWLEQHLPLVERWRAMLVELRAASGTD 1595
Cdd:pfam05088 1438 WLREQISALPVDNRWQALARAALRDDLYAQQRALTASVLASSDPDGDAEARVAAWLEANAAALERWRAMLAEIRASSGLD 1517

                         1530
                   ....*....|...
gi 489194165  1596 YAMYAVANRELMD 1608
Cdd:pfam05088 1518 LAMLSVALRELRD 1530
PTZ00324 PTZ00324
glutamate dehydrogenase 2; Provisional
 682-1177 4.85e-19

glutamate dehydrogenase 2; Provisional


Pssm-ID: 240359 [Multi-domain]  Cd Length: 1002  Bit Score: 94.10  E-value: 4.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  682 FDLGYIASALNAHTDIARELVRLFktrfylARKLTAEDLEDKQQKLEqaILGALDEVQVLNEDR-ILRRYLDLIKATLRT 760
Cdd:PTZ00324  376 FSERYIGEAIALYPEFVKLLYEDF------RLGHTPERRAAITQKIE--ETARLKEDIRNELDRtIFSAFLSFNEHILKT 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  761 NFYQpdgngQNKSYFSFKFNPKAIPELPRPVPKYEIF-VYSPRVEGVHLRGGKVARGGLRW--SDREEDFRT-------E 830
Cdd:PTZ00324  448 NFYK-----TEKTALAFRLDPSFLSELEYPRVPYGVFlVAGAQFRGFHIRFTDIARGGVRMiqSFKEQAYRRnkrsvfdE 522

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  831 VLGLVKAQQVKNAVIVPVGAKGGFvprrlpLGGSRDEIQAEAIACYRIF---ISGLLDItdnlkegeVVPPANVVRHDED 907
Cdd:PTZ00324  523 NYNLASTQLLKNKDIPEGGSKGTI------LLSSRYLNKFAQVRCQHAFlqyIDALLDV--------MLPGEKVVDHLKQ 588

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  908 DPYLVVAADK-GTATFSDIANGIAAEYGFWLGDAFASGGS---AGYDHKGMGITAKG--AWV-SVQRHFRERGIDVQKdn 980
Cdd:PTZ00324  589 EEIIFLGPDEhTTGTLMDWAALHAKKRGYPFWKSFTTGKSpsmGGIPHDTYGMTTRSvrAYVtGILEKLGLNEEEVTK-- 666

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  981 isvIGIGDMAGDVFGNGLLMSdKLQLVAAFNHMHIFIDPNPdaassfVERQRLFNLP--RSSWADYDAKLISAGGGIFLR 1058
Cdd:PTZ00324  667 ---FQTGGPDGDLGSNELLLS-KEKTVGIVDGSGVLHDPEG------LNREELRRLAhhRLPAREFDESKLSPQGFLVLT 736

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1059 SAKSIAItPEMkarfDIQADRLAPTELIHALLKAPVDLLWN-GGigtyvKSSKETHADVGDKandgLRVDGRELRAKVVG 1137
Cdd:PTZ00324  737 DDRDVKL-PDG----TIVESGLRFRNEFHLLPYSDADVFVPcGG-----RPRSVTLFNVGRF----FDEKNGKLRFKIIV 802

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 489194165 1138 EGGNLGMTQLARVEFGLHGGANNTDFIDNAGGVDCSDHEV 1177
Cdd:PTZ00324  803 EGANLFITQDARLALEECGVILFKDASANKGGVTSSSLEV 842
ELFV_dehydrog smart00839
Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glutamate, leucine, phenylalanine and ...
 1131-1208 1.49e-03

Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glutamate, leucine, phenylalanine and valine dehydrogenases are structurally and functionally related. They contain a Gly-rich region containing a conserved Lys residue, which has been implicated in the catalytic activity, in each case a reversible oxidative deamination reaction.


Pssm-ID: 214847 [Multi-domain]  Cd Length: 102  Bit Score: 39.50  E-value: 1.49e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489194165   1131 LRAKVVGEGGNLGMTQLARVEFGLHGGANNTDFIDNAGGVDCSDHevnikillnEVVQAGDMT-EKQRNALLVKMTDAV 1208
Cdd:smart00839   23 LGAKIIAEGANMPLTDEADDILEDRGVLYAPDFAANAGGVIVSAL---------EMLQNLARTaEEVFTDLSEIMRNAL 92
 
Name Accession Description Interval E-value
Gdh2 COG2902
NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism];
5-1610 0e+00

NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism];


Pssm-ID: 442147 [Multi-domain]  Cd Length: 1607  Bit Score: 2726.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165    5 TAASKADFQHQLQTALAQHLGDKALPQVTLFAEQFFSLISLDELTQRRLSDLVGCTLSAWRLLERFDRDQPEVRVYNPDY 84
Cdd:COG2902     3 SEASKAELLEAVAELIAERLPAAQAPLVAAFARQYYRHVPPEDLAARSPEDLYGAALSHWQLAQQRKPGEPKVRVFNPDL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   85 EKHGWQSTHTAVEVLHPDLPFLVDSVRMELNRRGYSIHTLQTNVLSVRRSAKGELKEILPKGSQGKDVSQESLMYLEIDR 164
Cdd:COG2902    83 EEHGWQSTHTVVEIVTDDMPFLVDSVTMELNRLGLTIHLVVHPVLAVERDADGELVEVLPADEAPADGLRESLIHIEIDR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  165 CAHAGELRALEKAILEVLGEVRVTVADFEPMKAKARELLTWLGKAKLKVPAEELKEVRSYLEWLLDNHFTFLGYEEFSVA 244
Cdd:COG2902   163 QTDPEALEELEAELERVLADVRAAVEDWPAMRARLLEIAAELEAAPPPVDADEVAEAAAFLRWLADDHFTFLGYREYDLV 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  245 DEADGGRMVYDEKSFLGLTRLLRAGLSKDDL-HIEDYAVAYLREPVLLSFAKAAHPSRVHRPAYPDYVSIRELDGKGRVI 323
Cdd:COG2902   243 GEDGDDVLRPVPGSGLGILRDDSVRVRGRSLsALPPEARAFAREPDLLILTKANSRSTVHRPAYLDYIGVKRFDADGEVI 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  324 RECRFMGLFTSSVYNESVNDIPFIRGKVAEVMRRSGFDTKAHLGKELAQVLEVLPRDDLFQTPVDELFSTALAIVRIQER 403
Cdd:COG2902   323 GERRFLGLFTSTAYNESVRDIPLLRRKVEAVLERSGFDPGSHSGKALLNILETYPRDELFQISEDELLETALGILHLQER 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  404 NKIRVFLRKDPYGRFCYCLAYVPRDVYSTETRLKIQQVLMERLQASDCEFWTFFSESVLARVQFILRVDPKSRIDIDPAR 483
Cdd:COG2902   403 RRVRLFLRRDPFGRFVSCLVYVPRDRYNTELRLRIQAILAEAFGGESVEFTTYFSESVLARVHFIVRVDPGELPDVDVAE 482

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  484 LEEEVIQACRSWQDDYSSLVVENLGEAKGTNVLADFPKGFPAGYRERFAPHFAVVDLQHLLSLSEQRPLVMSFYQPLAQG 563
Cdd:COG2902   483 LEARLAEAARSWEDDLREALVERFGEERGNRLARRYADAFPAGYREDFSPRTAVADIERLESLSEEGPLAMSLYRPLEAD 562

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  564 EQQLHCKLYHADTPLALSDVLPILENLGLRVLGEFPYRLRHQNGREYWIHDFAFTYAEGLDVDIQQLNEILQDAFVHIVS 643
Cdd:COG2902   563 PGELRLKLYHRGEPIPLSDVLPVLENMGLRVIDERPYEIEPADGEPVWIHDFGLEYPGGGEIDLDEVRELFEDAFAAVWR 642

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  644 GDAENDAFNRLVLTANLPWRDVALLRAYARYLKQIRLGFDLGYIASALNAHTDIARELVRLFKTRFYLARKltAEDLEDK 723
Cdd:COG2902   643 GEAENDGFNRLVLAAGLTWREVAVLRAYARYLRQIGFPFSQDYIEDTLARHPAIARLLVELFEARFDPARD--DDDREER 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  724 QQKLEQAILGALDEVQVLNEDRILRRYLDLIKATLRTNFYQPDGNGQNKSYFSFKFNPKAIPELPRPVPKYEIFVYSPRV 803
Cdd:COG2902   721 AAALREEIEAALDEVASLDEDRILRRFLNLIQATLRTNFYQRDADGQPKPYLSFKLDPRKIPDLPLPRPMFEIFVYSPRV 800

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  804 EGVHLRGGKVARGGLRWSDREEDFRTEVLGLVKAQQVKNAVIVPVGAKGGFVPRRLPLGGSRDEIQAEAIACYRIFISGL 883
Cdd:COG2902   801 EGVHLRGGKVARGGLRWSDRREDFRTEVLGLVKAQMVKNAVIVPVGAKGGFVVKRLPAPGDREAWLAEGIACYKTFIRGL 880

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  884 LDITDNLKEGEVVPPANVVRHDEDDPYLVVAADKGTATFSDIANGIAAEYGFWLGDAFASGGSAGYDHKGMGITAKGAWV 963
Cdd:COG2902   881 LDITDNLVGGEVVPPEDVVRHDGDDPYLVVAADKGTATFSDIANGISAEYGFWLGDAFASGGSVGYDHKKMGITARGAWE 960

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  964 SVQRHFRERGIDVQKDNISVIGIGDMAGDVFGNGLLMSDKLQLVAAFNHMHIFIDPNPDAASSFVERQRLFNLPRSSWAD 1043
Cdd:COG2902   961 SVKRHFRELGIDIQTEDFTVVGIGDMSGDVFGNGMLLSEHIRLVAAFDHRHIFIDPNPDAAASFAERKRLFELPRSSWAD 1040

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1044 YDAKLISAGGGIFLRSAKSIAITPEMKARFDIQADRLAPTELIHALLKAPVDLLWNGGIGTYVKSSKETHADVGDKANDG 1123
Cdd:COG2902  1041 YDKSLISKGGGVFSRSAKSIPLSPEMRAALGIEVDSLTPNELIRAILKAPVDLLWNGGIGTYVKASTESHADVGDRANDA 1120

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1124 LRVDGRELRAKVVGEGGNLGMTQLARVEFGLHGGANNTDFIDNAGGVDCSDHEVNIKILLNEVVQAGDMTEKQRNALLVK 1203
Cdd:COG2902  1121 LRVNGSELRAKVVGEGGNLGLTQLGRIEYALNGGRINTDAIDNSAGVDCSDHEVNIKILLNRLVADGDLTLKQRNKLLAE 1200

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1204 MTDAVGALVLGNNYKQTQALSLAQRRARERIAEYKRLMGDLEARGKLDRALEFLPSDEELAERISAGQGLTRAELSVLIS 1283
Cdd:COG2902  1201 MTDEVAELVLRDNYRQTQALSLAEAQAAERLGEHARFIRALERAGRLDRALEFLPSDEELAERRAAGQGLTRPELAVLLA 1280

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1284 YSKIDLKESLLKSLVPDDDYLTRDMETAFPALLAEKFGDAMRRHRLKREIVSTQIANDLVNHMGITFVQRLKESTGMSAA 1363
Cdd:COG2902  1281 YAKIVLKDELLASDLPDDPYLARELVRYFPKPLRERFADEIAEHPLRREIIATQLANDMVNRMGITFVFRLQEETGASAA 1360

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1364 NVAGAYVIVRDVFHLPHWFRQIENLDYQVPADIQLTLMDELMRLGRRATRWFLRSRRNELDAARDVAHFGPRIAALGLKL 1443
Cdd:COG2902  1361 DIARAYVIAREVFGLPALWAAIEALDNKVPADVQLEMLLEVRRLLRRATRWFLRNRRQPLDIAAVIERFRPGVAALRPAL 1440

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1444 NELLEGPTRELWQARYQTYVDAGVPELLARMVAGTSHLYTLLPIIEASDVTGQDTAEVAKAYFAVGSALDLTWYLQQITN 1523
Cdd:COG2902  1441 PELLPGEEREALEARAAELVEAGVPEDLARRIAALPYLYSALDIVEVAEETGRDVAEVARVYFALGDRLGLDWLREQISA 1520

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1524 LPVENNWQALAREAFRDDLDWQQRAITVSVLQMQDGPKEVEARVGLWLEQHLPLVERWRAMLVELRAASGTDYAMYAVAN 1603
Cdd:COG2902  1521 LPVDDRWQALARAALRDDLYAQQRALTAAVLRSTDPGEDAEERVEAWLEANAAALERWRQMLAEIRASGTLDLAMLSVAL 1600


                  ....*..
gi 489194165 1604 RELMDLA 1610
Cdd:COG2902  1601 RELRDLA 1607
Bac_GDH pfam05088
Bacterial NAD-glutamate dehydrogenase; This family consists of several bacterial proteins ...
 77-1608 0e+00

Bacterial NAD-glutamate dehydrogenase; This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyze the reversible oxidative deamination of glutamate to ketoglutarate and ammonia.


Pssm-ID: 428297 [Multi-domain]  Cd Length: 1530  Bit Score: 2653.36  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165    77 VRVYNPDYEKHGWQSTHTAVEVLHPDLPFLVDSVRMELNRRGYSIHTLQTNVLSVRRSAKGELKEILPKGSQGKDVSQES 156
Cdd:pfam05088    1 VRVFNPDLEEHGWQSTHTVVEIVNDDMPFLVDSVTMELNRQGLTIHLVVHPVLVVRRDADGKLVEVLPAADAAAGAAGES 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   157 LMYLEIDRCAHAGELRALEKAILEVLGEVRVTVADFEPMKAKARELLTWLGKAKLKVPAEELKEVRSYLEWLLDNHFTFL 236
Cdd:pfam05088   81 LIHIEIDRQTDPERLEALEAELERVLADVRAAVEDWPAMRARLLAIAAELETAPPPVSADEVEEAAAFLRWLADDHFTFL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   237 GYEEFSVADEADGGRMVYDEKSFLGLTRLLRAGLSKDDL-HIEDYAVAYLREPVLLSFAKAAHPSRVHRPAYPDYVSIRE 315
Cdd:pfam05088  161 GYREYDLVEDEGGGVLRAVPGSGLGILRDDSVLPRSRSLaALPPEARAFALEPELLILTKANSRSTVHRPAYLDYVGVKR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   316 LDGKGRVIRECRFMGLFTSSVYNESVNDIPFIRGKVAEVMRRSGFDTKAHLGKELAQVLEVLPRDDLFQTPVDELFSTAL 395
Cdd:pfam05088  241 FDADGEVIGERRFLGLFTSTAYNESPREIPLLRRKVARVLERSGFDPGSHSGKALLNILETYPRDELFQISEDELLEIAL 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   396 AIVRIQERNKIRVFLRKDPYGRFCYCLAYVPRDVYSTETRLKIQQVLMERLQASDCEFWTFFSESVLARVQFILRVDPKS 475
Cdd:pfam05088  321 GILHLQERRRVRLFLRRDPFGRFVSCLVYVPRDRYNTELRLRIQAILAEALGGTDVEFTTYFSESVLARLHFIVRVDPGN 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   476 RIDIDPARLEEEVIQACRSWQDDYSSLVVENLGEAKGTNVLADFPKGFPAGYRERFAPHFAVVDLQHLLSLSEQRPLVMS 555
Cdd:pfam05088  401 PPEVDVAELEARLAEAARSWEDDLREALVEAHGEERGNRLARRYADAFPAAYKEDFSPRSAVADIERLEALSEEGDLAMS 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   556 FYQPLAQGEQQLHCKLYHADTPLALSDVLPILENLGLRVLGEFPYRLRHQNGREYWIHDFAFTYAEGLDVDIQQLNEILQ 635
Cdd:pfam05088  481 LYRPLEADPGELRLKLYRRGEPLPLSDVLPMLENMGLRVIDERPYEIRPADGKRVWIHDFGLRYAGGAALDLDEVRELFE 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   636 DAFVHIVSGDAENDAFNRLVLTANLPWRDVALLRAYARYLKQIRLGFDLGYIASALNAHTDIARELVRLFKTRFYLARkl 715
Cdd:pfam05088  561 DAFAAVWRGEAENDGFNRLVLRAGLTWREVAVLRAYARYLRQIGFTFSQDYIEDTLAAHPDIARLLVALFEARFDPAL-- 638

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   716 tAEDLEDKQQKLEQAILGALDEVQVLNEDRILRRYLDLIKATLRTNFYQPDGNGQNKSYFSFKFNPKAIPELPRPVPKYE 795
Cdd:pfam05088  639 -AAGREARAEALEAEILAALDEVASLDEDRILRRYLNLIEATLRTNFYQRDADGQPKPYISFKLDPRAIPDLPLPRPMFE 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   796 IFVYSPRVEGVHLRGGKVARGGLRWSDREEDFRTEVLGLVKAQQVKNAVIVPVGAKGGFVPRRLPLGGSRDEIQAEAIAC 875
Cdd:pfam05088  718 IFVYSPRVEGVHLRGGKVARGGLRWSDRREDFRTEVLGLVKAQMVKNAVIVPVGAKGGFVVKRLPPAGDREAWLAEGIAC 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   876 YRIFISGLLDITDNLKEGEVVPPANVVRHDEDDPYLVVAADKGTATFSDIANGIAAEYGFWLGDAFASGGSAGYDHKGMG 955
Cdd:pfam05088  798 YKTFIRGLLDITDNLVDGEVVPPADVVRHDGDDPYLVVAADKGTATFSDIANGISAEYGFWLGDAFASGGSVGYDHKKMG 877

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165   956 ITAKGAWVSVQRHFRERGIDVQKDNISVIGIGDMAGDVFGNGLLMSDKLQLVAAFNHMHIFIDPNPDAASSFVERQRLFN 1035
Cdd:pfam05088  878 ITARGAWESVKRHFRELGVDTQTEDFTVVGIGDMSGDVFGNGMLLSEHIRLVAAFNHRHIFIDPDPDAAASFAERKRLFE 957

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1036 LPRSSWADYDAKLISAGGGIFLRSAKSIAITPEMKARFDIQADRLAPTELIHALLKAPVDLLWNGGIGTYVKSSKETHAD 1115
Cdd:pfam05088  958 LPRSSWADYDRSLISAGGGVFPRSAKSIPLSPEMRAALGIEKDVLTPNELIRAILKAPVDLLWNGGIGTYVKASTETHAD 1037

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1116 VGDKANDGLRVDGRELRAKVVGEGGNLGMTQLARVEFGLHGGANNTDFIDNAGGVDCSDHEVNIKILLNEVVQAGDMTEK 1195
Cdd:pfam05088 1038 VGDKANDALRVNGSELRAKVVGEGGNLGLTQLGRIEYALNGGRINTDAIDNSAGVDCSDHEVNIKILLNGVVAAGDLTLK 1117

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1196 QRNALLVKMTDAVGALVLGNNYKQTQALSLAQRRARERIAEYKRLMGDLEARGKLDRALEFLPSDEELAERISAGQGLTR 1275
Cdd:pfam05088 1118 QRNALLAEMTDEVAELVLRDNYRQTQALSLAEAQAAERLDEHARLIRALEREGRLDRALEFLPSDEELAERKAAGQGLTR 1197

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1276 AELSVLISYSKIDLKESLLKSLVPDDDYLTRDMETAFPALLAEKFGDAMRRHRLKREIVSTQIANDLVNHMGITFVQRLK 1355
Cdd:pfam05088 1198 PELAVLLAYAKIVLKDELLASDLPDDPYLARELVRYFPTPLRERFAEAIARHPLRREIIATQLANDMVNRMGITFVFRLQ 1277

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1356 ESTGMSAANVAGAYVIVRDVFHLPHWFRQIENLDYQVPADIQLTLMDELMRLGRRATRWFLRSRRNELDAARDVAHFGPR 1435
Cdd:pfam05088 1278 EETGASVADVARAYVIAREVFGLPELWAQIEALDNKVPAAVQTEMLLEVRRLVRRATRWLLRNRRQPLDIAATIARFAPG 1357

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1436 IAALGLKLNELLEGPTRELWQARYQTYVDAGVPELLARMVAGTSHLYTLLPIIEASDVTGQDTAEVAKAYFAVGSALDLT 1515
Cdd:pfam05088 1358 VAALAAQLPELLPGAEREALQARAARLVEAGVPEELARRVAGLPYLYSALDIVEVAEATGRDLEEVARVYFALGDRLGLD 1437

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  1516 WYLQQITNLPVENNWQALAREAFRDDLDWQQRAITVSVLQMQDGPKEVEARVGLWLEQHLPLVERWRAMLVELRAASGTD 1595
Cdd:pfam05088 1438 WLREQISALPVDNRWQALARAALRDDLYAQQRALTASVLASSDPDGDAEARVAAWLEANAAALERWRAMLAEIRASSGLD 1517

                         1530
                   ....*....|...
gi 489194165  1596 YAMYAVANRELMD 1608
Cdd:pfam05088 1518 LAMLSVALRELRD 1530
PTZ00324 PTZ00324
glutamate dehydrogenase 2; Provisional
 682-1177 4.85e-19

glutamate dehydrogenase 2; Provisional


Pssm-ID: 240359 [Multi-domain]  Cd Length: 1002  Bit Score: 94.10  E-value: 4.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  682 FDLGYIASALNAHTDIARELVRLFktrfylARKLTAEDLEDKQQKLEqaILGALDEVQVLNEDR-ILRRYLDLIKATLRT 760
Cdd:PTZ00324  376 FSERYIGEAIALYPEFVKLLYEDF------RLGHTPERRAAITQKIE--ETARLKEDIRNELDRtIFSAFLSFNEHILKT 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  761 NFYQpdgngQNKSYFSFKFNPKAIPELPRPVPKYEIF-VYSPRVEGVHLRGGKVARGGLRW--SDREEDFRT-------E 830
Cdd:PTZ00324  448 NFYK-----TEKTALAFRLDPSFLSELEYPRVPYGVFlVAGAQFRGFHIRFTDIARGGVRMiqSFKEQAYRRnkrsvfdE 522

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  831 VLGLVKAQQVKNAVIVPVGAKGGFvprrlpLGGSRDEIQAEAIACYRIF---ISGLLDItdnlkegeVVPPANVVRHDED 907
Cdd:PTZ00324  523 NYNLASTQLLKNKDIPEGGSKGTI------LLSSRYLNKFAQVRCQHAFlqyIDALLDV--------MLPGEKVVDHLKQ 588

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  908 DPYLVVAADK-GTATFSDIANGIAAEYGFWLGDAFASGGS---AGYDHKGMGITAKG--AWV-SVQRHFRERGIDVQKdn 980
Cdd:PTZ00324  589 EEIIFLGPDEhTTGTLMDWAALHAKKRGYPFWKSFTTGKSpsmGGIPHDTYGMTTRSvrAYVtGILEKLGLNEEEVTK-- 666

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165  981 isvIGIGDMAGDVFGNGLLMSdKLQLVAAFNHMHIFIDPNPdaassfVERQRLFNLP--RSSWADYDAKLISAGGGIFLR 1058
Cdd:PTZ00324  667 ---FQTGGPDGDLGSNELLLS-KEKTVGIVDGSGVLHDPEG------LNREELRRLAhhRLPAREFDESKLSPQGFLVLT 736

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489194165 1059 SAKSIAItPEMkarfDIQADRLAPTELIHALLKAPVDLLWN-GGigtyvKSSKETHADVGDKandgLRVDGRELRAKVVG 1137
Cdd:PTZ00324  737 DDRDVKL-PDG----TIVESGLRFRNEFHLLPYSDADVFVPcGG-----RPRSVTLFNVGRF----FDEKNGKLRFKIIV 802

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 489194165 1138 EGGNLGMTQLARVEFGLHGGANNTDFIDNAGGVDCSDHEV 1177
Cdd:PTZ00324  803 EGANLFITQDARLALEECGVILFKDASANKGGVTSSSLEV 842
ELFV_dehydrog smart00839
Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glutamate, leucine, phenylalanine and ...
 1131-1208 1.49e-03

Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glutamate, leucine, phenylalanine and valine dehydrogenases are structurally and functionally related. They contain a Gly-rich region containing a conserved Lys residue, which has been implicated in the catalytic activity, in each case a reversible oxidative deamination reaction.


Pssm-ID: 214847 [Multi-domain]  Cd Length: 102  Bit Score: 39.50  E-value: 1.49e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489194165   1131 LRAKVVGEGGNLGMTQLARVEFGLHGGANNTDFIDNAGGVDCSDHevnikillnEVVQAGDMT-EKQRNALLVKMTDAV 1208
Cdd:smart00839   23 LGAKIIAEGANMPLTDEADDILEDRGVLYAPDFAANAGGVIVSAL---------EMLQNLARTaEEVFTDLSEIMRNAL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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