|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
9-419 |
0e+00 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 644.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 9 SNEERRKRIFAIVGASSGNLVEWFDFYVYAFCAIYFAPAFFPSDNPTVQLLNTAGVFAAGFLMRPIGGWMFGRIADKHGR 88
Cdd:PRK10406 13 TSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 89 KTAMLISVVMMCAGSLAIACMPTYASIGTLAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGG 168
Cdd:PRK10406 93 KKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 169 QLLAVLVVVILQQLLSEDELRAWGWRIPFVIGAITAVIALWLRRSLNETASKSTLERKESGTFAELFKHKRAFFTVLGFT 248
Cdd:PRK10406 173 QLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALKEAGSLKGLWRNRRAFIMVLGFT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 249 AGGSLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKT 328
Cdd:PRK10406 253 AAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAALFTVPILSALQN 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 329 VSSPYMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFGGSAEYVALGLKSVGMENVFYWYVSAM 408
Cdd:PRK10406 333 VSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSIGMETAFFWYVTLM 412
|
410
....*....|.
gi 489224681 409 CLLALLVCVSL 419
Cdd:PRK10406 413 AVVAFLVSLML 423
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
20-423 |
0e+00 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 528.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 20 IVGASSGNLVEWFDFYVYAFCAIYFAPAFFPSDNPTVQLLNTAGVFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVMM 99
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 100 CAGSLAIACMPTYASIGTLAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVIL 179
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 180 QQLLSEDELRAWGWRIPFVIGAITAVIALWLRRSLNETAS---KSTLERKESGTFAELFKHKRAFFTVLGFTAGGSLIFY 256
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESfeaIAESNEASAGTLRELRRHPRELLLVVGLTAGGTLAFY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 257 TFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAF 336
Cdd:cd17367 241 TWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 337 FLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFGGSAEYVALGLKSVGMENVFYWYVSAMCLLALLVC 416
Cdd:cd17367 321 ALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVFFWYVAGLIAISLVVY 400
|
....*..
gi 489224681 417 VSLPDLR 423
Cdd:cd17367 401 LRMPETR 407
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
26-414 |
2.17e-147 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 424.76 E-value: 2.17e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 26 GNLVEWFDFYVYAFCAIYFAPAFFP-SDNPTVQLLNTAGVFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVMMCAGSL 104
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPpSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 105 AIACMPTYASIGTLAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVILQQLLS 184
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 185 EDELRAWGWRIPFVIGAITAVIALWLRRSLNETASKSTLE---RKESGTFAELF-KHKRAFFTVLGFTAGGSLIFYTFTT 260
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQekhKKKRGPIAETLtKHRKPFLLGLGLVIATTTTFYLITT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 261 YMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAFFLII 340
Cdd:TIGR00883 241 YLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFFFLVL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489224681 341 LALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFGGSAEYVALGLKSVGMENVFYWYVSAMCLLALL 414
Cdd:TIGR00883 321 GMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIGL 394
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
19-417 |
5.72e-92 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 283.65 E-value: 5.72e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 19 AIVGASSGNLVEWFDFYVYAFCA-IYFAPAFFPSDNPTVQLLNTAGVFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVV 97
Cdd:cd17369 3 VALASLVGTAIEWYDFFIYGTAAaLVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 98 MMCAGSLAIACMPTYASIGTLAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVV 177
Cdd:cd17369 83 LMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 178 ILQQLLSEDELRAWGWRIPFVIGAITAVIALWLRRSLNET----ASKSTLERKESGTFAELFKHKRAFFTVLGFTAGGSL 253
Cdd:cd17369 163 LLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETpvfrRAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAENV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 254 IFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPY 333
Cdd:cd17369 243 LFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 334 MAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFGGSAEYVALGLkSVGMENVFY--WYVSAMCLL 411
Cdd:cd17369 323 IVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATAL-VAATGSWWPvaLYLAALAVI 401
|
....*.
gi 489224681 412 ALLVCV 417
Cdd:cd17369 402 SLVAAL 407
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
20-414 |
1.16e-76 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 244.21 E-value: 1.16e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 20 IVGASSGNLVEWFDFYVYAFCAIYFAPAFFPSDNPTVQLLNTAGVFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVMM 99
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 100 CAGSLAIACMPTYASIGTLAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVIL 179
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 180 QQLLSEDELRAWGWRIPFVIGAITAVIALWLRRSLNET----ASKSTLERkeSGTFAELFKHKRAFFTVLGFTAGGSLIF 255
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETeaflERKARPTR--RELFALLANNRRIILLGMLLVAGSTVTF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 256 YTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMA 335
Cdd:cd17368 239 YFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSFGRL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 336 FFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFGGSAEYVALGLKSVGMENVF-YWYV---SAMCLL 411
Cdd:cd17368 319 LLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLApAWYLmgaALLGLL 398
|
...
gi 489224681 412 ALL 414
Cdd:cd17368 399 ATL 401
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
20-421 |
5.87e-72 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 231.09 E-value: 5.87e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 20 IVGASSGNLVEWFDFYVYAFCAIYFAPAFFPSDNPTVQLLNTAGVFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVMM 99
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 100 CAGSLAIACMPTYASIGTLAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVIL 179
Cdd:cd17366 81 AASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 180 QQLLSEDELRAWGWRIPFVIGAITAVIALWLRRSLnetaskstlerkesgtfaelfkhkrafFTVLGFTAGGSLIFYTFT 259
Cdd:cd17366 161 TLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLRRPL---------------------------LICIGLVLVFNVTNYMLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 260 TYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKtSMLWFGTLGTLC-TLPILLALKTVSSPYMAFFL 338
Cdd:cd17366 214 SYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRK-PVYAAGLAGLLVlAVPAFLLMNSGSIAAIFIGL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 339 IILALaIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFGGSAEYVALGLKSV-GMENVFYWYVSAMCLLALLVCV 417
Cdd:cd17366 293 LVLGL-LLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSAtGNPLMPAYYLMVAAVVGLVAVL 371
|
....
gi 489224681 418 SLPD 421
Cdd:cd17366 372 FLTE 375
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-417 |
3.18e-69 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 223.25 E-value: 3.18e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 20 IVGASSGNLVEWFDFYVYAFCAIYFAPAFfpsdNPTVQLLNTAGVFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVMM 99
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 100 CAGSLAIACMPTYASIGTlapallllARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVIL 179
Cdd:cd17316 77 GLATLLIGLLPTPILLLV--------LRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 180 QQLLSEDelraWGWRIPFVIGAITAVIALWLRRSLnetaskstlerkesgtfaelfkhkrafFTVLGFTAGGSLIFYTFT 259
Cdd:cd17316 149 IPLLSGD----WGWRILFLIGALPALLALLLRRRT---------------------------LLLILLWFFISFGYYGLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 260 TYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTvsSPYMAFFLI 339
Cdd:cd17316 198 TFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSG--SPTLLLLLL 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489224681 340 ILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFGGSAEYVALGLKSVGMENVFYWYVSAMCLLALLVCV 417
Cdd:cd17316 276 FILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
1-383 |
1.07e-65 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 216.35 E-value: 1.07e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 1 MTAPVHQYSNEERRKRIFAIVgasSGNLVEWFDFYVYAFCAIYFAPAFFPSDNPTVQLLNTAGVFAAGFLMRPIGGWMFG 80
Cdd:PRK15075 1 MSTMTPAASRESKARAILRVT---SGNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 81 RIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIGTLAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASF 160
Cdd:PRK15075 78 AYIDRVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 161 Q---------YVTLIGgqllavlvvVILQQLLSEDELRAWGWRIPFVIGAITAVIALWLRRSLNETAskSTLERKESGTF 231
Cdd:PRK15075 158 QsasqqvavvFAALLG---------YLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETE--EFLARKHRPSM 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 232 AELFKHKRAFFTVLgfTAGGSLI------FYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRK 305
Cdd:PRK15075 227 REIFRSLAANWRIV--LAGMLMVamttvsFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRR 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 306 TSMLWFGTLGTLCTLPILLALktVSSPYMAFFLIILaLAIVSLYTSISG-LIKA--EMFPPEVRALGVGVSYAVGNAIFG 382
Cdd:PRK15075 305 PVLIAFTVLAILTAYPALSWL--VAAPSFARMLAVE-LWLSFLYGSYNGaMVVAltEVMPAEVRTAGFSLAYSLATAIFG 381
|
.
gi 489224681 383 G 383
Cdd:PRK15075 382 G 382
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
19-382 |
6.13e-56 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 192.23 E-value: 6.13e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 19 AIVGASSGNLVEWFDFYVYAFCAIYFAPAFFPSDNPTVQLLNTAGVFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVM 98
Cdd:PRK10642 17 AITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 99 MCAGSLAIACMPTYASIGTLAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVI 178
Cdd:PRK10642 97 MSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 179 LQQLLSEDELRAWGWRIPFVIGAITAVIALWLRRSLNET------------ASKSTLERKESGTFAELF-KHKRAFFTVL 245
Cdd:PRK10642 177 ISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETpafqqhvdkleqGDREGLQDGPKVSFKEIAtKHWRSLLTCI 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 246 GFTAGGSLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKtSMLWFGTLGTLC-TLPILL 324
Cdd:PRK10642 257 GLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRR-PFVILGSVALFVlAIPAFI 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489224681 325 ALKTVSSPYMAFFLIILALaIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFG 382
Cdd:PRK10642 336 LINSNVIGLIFAGLLMLAV-ILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAG 392
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
19-415 |
1.13e-52 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 182.24 E-value: 1.13e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 19 AIVGASSGNLVEWFDFYVYAF-CAIYFAPAFFPSDNPTVQLLNTAGVFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVV 97
Cdd:PRK09952 23 AALGSFAGAVVDWYDFLLYGItAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLTVW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 98 MMCAGSLAIACMPTYASIGTLAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVV 177
Cdd:PRK09952 103 MMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 178 ILQQLLSEDELRAWGWRIPFVIGAITAVIALWLRRSLNETA------SKSTLERKESGTFAELFKHKRAFFTVLGFTAGG 251
Cdd:PRK09952 183 LISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAefeqqqHEQAAAKKRIPVIEALLRHPGAFLKIIALRLCE 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 252 SLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSS 331
Cdd:PRK09952 263 LLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSI 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 332 PYMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFGGSAEYVALGLKSVGMENvfyW-----YVS 406
Cdd:PRK09952 343 FWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTYFGGS---WhsvaiYLL 419
|
....*....
gi 489224681 407 AMCLLALLV 415
Cdd:PRK09952 420 AGCLISAMT 428
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-424 |
4.87e-30 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 119.99 E-value: 4.87e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 14 RKRIFAIVGASSGNLVEWFDFYVYAFCAIYFAPAFfpsdnpTVQLLNTAGVFAAGFLMRPIGGWMFGRIADKHGRKTAML 93
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF------GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 94 ISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAv 173
Cdd:COG2223 75 IGLLLLGIGLLLLALAVSYWLL--------LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVA- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 174 lvvvilqQLLSEDELRAWGWRIPFVI-GAITAVIALWLRRSLNETASKSTLERKES-GTFAELFKHKRAFFTVLGFtAGG 251
Cdd:COG2223 146 -------AFLAPLLIAAFGWRNAFLIlGILLLVVAVLAWLFLRDPPAGAAAAAKASlRDQLEALRDPRFWLLSLLY-FGT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 252 SLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSS 331
Cdd:COG2223 218 FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 332 PYMAFFLIILALAIVSlyTSISGLIkAEMFPPEVRALGVGVSYAVGNaiFGGSAEYVALG--LKSVGMENVFYWYVSAMC 409
Cdd:COG2223 298 FLVLFLLLGLALGGGN--GAVFALV-PDIFPTKNAGAVYGLVGAAGG--LGGFLGPLLFGalLDATGSYTAAFLVFAVLA 372
|
410
....*....|....*
gi 489224681 410 LLALLVCVSLPDLRK 424
Cdd:COG2223 373 LVALVLTLLLYRRPR 387
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-379 |
9.06e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 118.15 E-value: 9.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 10 NEERRKRIFAIVGASSGNLVEWFDFYVYAFCAIYFAPAFFPSDnPTVQLlntagVFAAGFLMRPIGGWMFGRIADKHGRK 89
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASP-AQAGL-----VVTAYLLGAALGAPLAGRLADRFGRR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 90 TAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQ 169
Cdd:COG2814 76 RVLLLGLLLFALGSLLCALAPSLWLL--------LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 170 LLAVLVVVILQQllsedelrAWGWRIPFVIGAITAVIALWLRRSLNEtASKSTLERKESGTFAELFKHkRAFFTVLGFTA 249
Cdd:COG2814 148 ALGPLLGGLLAD--------LFGWRWVFLVNAVLALLALLLLLRLLP-ESRPAARARLRGSLRELLRR-PRLLLLLLLAF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 250 GGSLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCtlpILLALKTV 329
Cdd:COG2814 218 LLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG---LLLLALAG 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 489224681 330 SSPYMAFFLIILALAIVSLYTSISGLIkAEMFPPEVRALGVGVSYAVGNA 379
Cdd:COG2814 295 SLWLLLLALFLLGFGFGLLFPLLQALV-AELAPPEARGRASGLYNSAFFL 343
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-424 |
3.83e-28 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 114.20 E-value: 3.83e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 13 RRKRIFAIVGASSGNLVEWFDFYVYAFCAIYFAPAFFPSDnptVQLlntAGVFAAGFLMRPIGGWMFGRIADKHGRKTAM 92
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSA---AQL---GLLASAFFLGYALGQIPAGLLADRFGRRRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 93 LISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFqyvTLIGGQLLA 172
Cdd:COG2271 79 AIGLLLWGLATLLFGFATSFWQL--------LLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGI---FNAGGPLGG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 173 VLVVVILQQLLSedelrAWGWRIPFVIGAITAVIALWLRrslnetaskstlerkesgtfaelfkhkraFFTVLGFTAGGS 252
Cdd:COG2271 148 ALAPPLLGWLLA-----AFGWRAAFLILGLPGLLLALLR-----------------------------FWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 253 LIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSmlWFGTLGTLCTLPILLALKTVSSP 332
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRK--LVLAIGLLLAALALLLLALLPSP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 333 YMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFGGSAEYVALGLKSVGMENVFYWYVSAMCLLA 412
Cdd:COG2271 272 ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAA 351
|
410
....*....|..
gi 489224681 413 LLVCVSLPDLRK 424
Cdd:COG2271 352 LLALLLLRETRK 363
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
74-421 |
3.11e-24 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 103.54 E-value: 3.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 74 IGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIGtlapalllLARMFQGLSVGGEYGTSATYMSEVALKGQ 153
Cdd:cd17371 49 IGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLL--------ILRALAGLGFGGEWAAGAALMAEYVPARH 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 154 RGFFASFQYvtliGGQLLAVLVVVILQQLLSEDELRAWGWRIPFVIGAITAVIALWLRRSLNETAskSTLERKESGTFAE 233
Cdd:cd17371 121 RGKALGYVQ----SGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPP--QWQAARAARRHFA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 234 LFKHKRAFFT--VLGFTAGGSL-------IFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGR 304
Cdd:cd17371 195 DRPSLRELFSppLLRTTLLASLlatgalgGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGR 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 305 KTsMLWFGTLGTLCTLPILLALKtvSSPYMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFGGS 384
Cdd:cd17371 275 RN-NFALFALGSAISILLYFFLP--LSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALF 351
|
330 340 350
....*....|....*....|....*....|....*..
gi 489224681 385 AEYVALGLKSVGMENVFYWYVSAMCLLALLVCVSLPD 421
Cdd:cd17371 352 PFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPE 388
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
14-317 |
3.21e-23 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 99.11 E-value: 3.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 14 RKRIFAIVGASSGNLVEWFDFYVYAFcAIYFAPAFFPSDNPTVQLlntagVFAAGFLMRPIGGWMFGRIADKHGRKTAML 93
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNV-ALPSIAADLGASSAQLGW-----IVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 94 ISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAV 173
Cdd:COG0477 84 IGLLLFGLASLLCGLAPSPELL--------IAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 174 LVVVILqqllsedeLRAWGWRIPFVIGAITAVIALWLRRSLNETASKSTLERKESGTFAELFKHKRAFFTVLGFTAGGSL 253
Cdd:COG0477 156 LLGGLL--------VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLL 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489224681 254 IFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTL 317
Cdd:COG0477 228 ALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
3-377 |
9.55e-22 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 97.46 E-value: 9.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 3 APVHQYSNEERRKRIFAivgASSGNLVEWFDFYVYAFCAIYFAPAFfpsdnpTVQLLNTAGVFAAGFLMRPIGGWMFGRI 82
Cdd:PRK03893 8 IPWYRHLNRAQWKAFSA---AWLGYLLDGFDFVLITLVLTEVQGEF------GLTTVQAASLISAAFISRWFGGLLLGAM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 83 ADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFqy 162
Cdd:PRK03893 79 GDRYGRRLAMVISIVLFSVGTLACGFAPGYWTL--------FIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGF-- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 163 vtLIGGQLLAVLVVVILQQLLSEdelrAWGWRIPFVIGAITAVIALWLRRSLNETAS-KSTLERKESG--TFAELFKHKR 239
Cdd:PRK03893 149 --LISGFSIGAVVAAQVYSLVVP----VWGWRALFFIGILPIIFALWLRKNLPEAEDwKEKHAGKAPVrtMVDILYRGEH 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 240 AFFTV-LGFTAGGSL-----------------------IFYTFT-----------------------------TYMQKYL 266
Cdd:PRK03893 223 RIINIlLTLAAAAALwfcfagnlqnaaivavlgllcaaIFISFMvqssgkrwptgvmlmvvvlfaflyswpiqALLPTYL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 267 VNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTvsspyMAFFLIILALAIV 346
Cdd:PRK03893 303 KTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLISQLLIIPVFAIGGA-----NVWVLGLLLFFQQ 377
|
410 420 430
....*....|....*....|....*....|....
gi 489224681 347 SLYTSISGLIK---AEMFPPEVRALGVGVSYAVG 377
Cdd:PRK03893 378 MLGQGISGLLPkliGGYFDTEQRAAGLGFTYNVG 411
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
23-420 |
4.20e-20 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 91.95 E-value: 4.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 23 ASSGNLVEWFDFYVYAfcAIYFAPAFF------PSDNPTVQLLNTAGVFAAGFLM-RPIGGWMFGRIADKHGRKTAMLIS 95
Cdd:pfam00083 5 AALGGFLFGYDTGVIG--AFLTLIDFFknfglsKSVSSLAALSVLSGLIVSIFSVgCFIGSLFAGKLGDRFGRKKSLLIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 96 VVMMCAGSLAIACmptyaSIGTLAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLV 175
Cdd:pfam00083 83 NVLFVIGAVLQGA-----AKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 176 VvilqqLLSEDELRAWGWRIPFVIGAITAVIAL-----------WLRRSLNETASKSTLER------------------- 225
Cdd:pfam00083 158 G-----LGLNKTSNSDGWRIPLGLQLVPALLLIigllflpesprWLVEKGRLEEAREVLAKlrgvpdvdreldeikdsle 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 226 ----KESGTFAELFK---HKRAFFTVLGFTAGGSLIFYTFTTYMQKYLVNTAGMSaktASAVMTFALFAYMLMQPLFG-M 297
Cdd:pfam00083 233 agqeAEKASWKELFStktRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLS---DSFLVTIIVGVVNFVFTFIAiF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 298 LSDRIGRKTSMLWFGTLGTLCTLPI--LLALKTVSSPYMAFFLIILALAIVSLY----TSISGLIKAEMFPPEVRALGVG 371
Cdd:pfam00083 310 LVDRFGRRPLLLLGAAGMAICFVILgiVALLGVSKSDWAGIVAIVFIALFIAFFamgwGPVPWVIVSELFPLSVRSKAMA 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 489224681 372 VSYAVGNAIFGGSAEYVALGLKSVGMENVFYWYVSAMCLLALLVCVSLP 420
Cdd:pfam00083 390 LATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVP 438
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
13-382 |
5.94e-18 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 85.10 E-value: 5.94e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 13 RRKRIFAIVGASSGNLVEWFDFYVYAFCAIYFAPAFfpsDNPTVQLlntAGVFAAGFLMRPIGGWMFGRIADKHGRKTAM 92
Cdd:TIGR00895 12 SRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEW---GLDPVQL---GFLFSAGLIGMAFGALFFGPLADRIGRRRVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 93 LISVVMMCAGSLAIACMPTYASIGtlapalllLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYV-----TLIG 167
Cdd:TIGR00895 86 LWSILLFSVFTLLCALATNVTQLL--------ILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCgypigAAVG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 168 GqllavlvvvilqqLLSEDELRAWGWRIPFVIGAITAVIALWL--------------------------------RRSLN 215
Cdd:TIGR00895 158 G-------------FLAGWLIPVFGWRSLFYVGGIAPLLLLLLlmrflpesidflvskrpetvrrivnaiapqmqAEAQS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 216 ETASKSTLERKESGTFAELFKHKRAFFTVL--GFTAGGSLIFYTFTTYMQKyLVNTAGMSAKTASAVMTFALFAYMLMQP 293
Cdd:TIGR00895 225 ALPEQKSTQGTKRSVFKALFQGKTARITVLlwLLYFMLLVGVYFLTNWLPK-LMVELGFSLSLAATGGALFNFGGVIGSI 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 294 LFGMLSDRIGRKTSMlwFGTLGTLCTLPILLAlkTVSSPYMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVS 373
Cdd:TIGR00895 304 IFGWLADRLGPRVTA--LLLLLGAVFAVLVGS--TLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWA 379
|
410
....*....|.
gi 489224681 374 YAVGN--AIFG 382
Cdd:TIGR00895 380 IGIGRlgAIIG 390
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
64-419 |
2.16e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.39 E-value: 2.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 64 VFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSAT 143
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQL--------LLARFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 144 YMSEVALKGQRG----FFASFQYV-----TLIGGqllavlvvvilqqLLSEdelrAWGWRIPFVIGAITAVIALWLR-RS 213
Cdd:cd17325 108 LIADIAPPEERGramgIFSSAIGLgfligPLLGG-------------LLAD----ALGYRAPFLVCAALALLALVLAlLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 214 LNETASKSTLERKESGTFAELFK---HKRAFFTVLGFTAGGSLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYML 290
Cdd:cd17325 171 LPEPRPPPNKRAVSAARLRSGLRlllRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 291 MQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLAlktvSSPYMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGV 370
Cdd:cd17325 251 SQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAM 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489224681 371 GVSYAVGNAIFGGSAEYVALGLKSVGMENVFYWyVSAMCLLALLVCVSL 419
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA-AAALLLLAAVLFLLL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
64-417 |
8.27e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 78.62 E-value: 8.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 64 VFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSAT 143
Cdd:cd06174 36 LFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLL--------LLGRFLLGLGSGLIDPAVLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 144 YMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVILQQLLSedelraWGWRIPFVIGAITAVIALWLRRSLNETASKSTL 223
Cdd:cd06174 108 LIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG------FGWRAVFLIAAALALLAAILLLLVVPDPPESAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 224 ERKESGTFAELFK------HKRAFFTVLGFTAGGSLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGM 297
Cdd:cd06174 182 AKNEEASSKSVLKllkrvlKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 298 LSDRIGRKTSMLWFGTLGTLCTLPILLALktvSSPYMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVG 377
Cdd:cd06174 262 LSDRLIGRKPLLLIGLLLMALGLALLLLA---PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFG 338
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 489224681 378 NAIFGGSAEYVALGLKSVGMENVFYWYVSAMCLLALLVCV 417
Cdd:cd06174 339 FLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
64-378 |
2.20e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 77.07 E-value: 2.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 64 VFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSAT 143
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLL--------LVLRVLQGLGAGALFPAALA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 144 YMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVILqqllsedeLRAWGWRIPFVIGAITAVIA-----LWLRRSLNETA 218
Cdd:pfam07690 109 LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL--------ASLFGWRAAFLILAILSLLAavlllLPRPPPESKRP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 219 SKSTLERKESGTFAELFKHKRAFFTVLGFtAGGSLIFYTFTTYMQKYlVNTAGMSAKTASAVMTFALFAYMLMQPLFGML 298
Cdd:pfam07690 181 KPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 299 SDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAFFLIILALAIVSLYTSISGLIkAEMFPPEVRALGVGVSYAVGN 378
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALV-SDLAPKEERGTASGLYNTAGS 337
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
79-415 |
4.72e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 76.05 E-value: 4.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 79 FGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFA 158
Cdd:cd17324 54 LGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALL--------LLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 159 SfqyvTLIGGQLLAVLVVVILQQLLSEdelrAWGWRIPF-VIGAITAVIALWLRRSLNETASKSTLERKESGTFAELFKH 237
Cdd:cd17324 126 G----LVFSGLTLGLVLGRPLGGLLGQ----LLGWRAAFlAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRN 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 238 KRAFFT-VLGFTAGGSliFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGt 316
Cdd:cd17324 198 PRLRLAyLITFLLFGG--FFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLA- 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 317 lctlpILLALKTVSSPYMAFFLIILALAIVSLYTSISGL-IKAEMFPPEVRALGVG---VSYAVGNAIFGgsaeyvALGl 392
Cdd:cd17324 275 -----AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALqTRVLRLAPEARGLASSlylAAYNLGGALGA------ALG- 342
|
330 340
....*....|....*....|...
gi 489224681 393 kSVGMENVFYWYVSAMCLLALLV 415
Cdd:cd17324 343 -GLVLDHGGWAGVGWVGAALLLL 364
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
64-415 |
6.83e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 75.31 E-value: 6.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 64 VFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIGtlapalllLARMFQGLSVGGEYGTSAT 143
Cdd:cd17365 39 VGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLA--------LLRFLTGLGLGAAMPNAIT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 144 YMSEVALKGQRGFFASFQYVTL-IGGQLLAvlvvvilqqLLSEDELRAWGWRIPFVIGAITAVIALWLRRslnetaskST 222
Cdd:cd17365 111 LVSEYAPARRRSLAVTLMFCGYpLGAALGG---------FLAAALIPAFGWRSVFLLGGVPPLILLPLLR--------GT 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 223 LerkesgTFAElfkhkrAFFTVLgftaggsLIFYTFTTYMQKyLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRI 302
Cdd:cd17365 174 L------LLWV------TFFMGL-------LLVYLLNSWLPK-LMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 303 GRKTSMLWFGTLGTLCTLpiLLALKTVSSPYMAFFLIILALAIVSLYTSISGLIkAEMFPPEVRALGVGVSYAVG--NAI 380
Cdd:cd17365 234 GPKRVLALFFALGAVSLA--LLGVSPASLVLLYVLVFLAGACVNGAQVGLYALA-ARFYPTEVRATGVGWALGVGrlGAI 310
|
330 340 350
....*....|....*....|....*....|....*
gi 489224681 381 FGGSAEYVALGLkSVGMENVFYWYVSAMCLLALLV 415
Cdd:cd17365 311 LGPLLGGLLLAA-GLGPESVFLALAIPAALGALAV 344
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
67-421 |
3.01e-14 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 74.19 E-value: 3.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 67 AGFLMRPIGGWMFGRIADKHGRKTAMLISVVMMCAGslaiacmpTYASIGTLAPALLLLARMFQGLSVGGEYGTSATYMS 146
Cdd:PRK12307 61 AAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVG--------TGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAV 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 147 EVALKGQRGFFASFqyvtLIGGQLLAVLVVVILQQLLSEdelrAWGWRIPFVIGAITAVIALWLRRSLNEtaSKSTLERK 226
Cdd:PRK12307 133 ESWPKHLKSKASAF----LVSGFGIGNIIAAYFMPSFAE----AYGWRAAFFVGLLPVLLVIYIRARAPE--SKEWEEAK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 227 ESG--------------TFAELFKHKRAFFTVLGFTAGGSL------IFYTFTTYMQKYLVNTAgmsakTASAVMTFALF 286
Cdd:PRK12307 203 LSGkgkhsqsawsvfslSMKGLFNRAQFPLTLCVFIVLFSIfganwpIFGLLPTYLAGEGFDTG-----VVSNLMTAAAF 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 287 AYMLMQPLFGMLSDRIGRKTSMlwfgTLGTLCTLPILLALKTVSSP-YMAFFLIILALAIVSLytSISGLIKA---EMFP 362
Cdd:PRK12307 278 GTVLGNIVWGLCADRIGLKKTF----SIGLLMSFLFIFPLFRIPQDnYLLLGACLFGLMATNV--GVGGLVPKflyDYFP 351
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489224681 363 PEVRALGVGVSYAVGNAifGGSAEYVALGLKSVGM---ENVFYWYVSAMCLLALLVCVSLPD 421
Cdd:PRK12307 352 LEVRGLGTGLIYNLAAT--SGTFNSMAATWLGITMglgAALTFIVAFWTATILLIIGLSIPD 411
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
74-415 |
3.10e-14 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 73.85 E-value: 3.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 74 IGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIGtlAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQ 153
Cdd:cd17364 54 IGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLG--VMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKR 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 154 RG----FFASFQYVTLIGGQLLAVLVVVILQQLLSEDELRA--WGWRIPFVIGAITAVIALWLRRSLNETASKstlerke 227
Cdd:cd17364 132 RGaliaAVFAMQGFGILAGAIVTLILSAIFEHPLPAGTYHHadLVWRIVLGLGAIPALSVLYFRKHLLGTAGT------- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 228 sgtfaeLFKHKRAFFtvlGFTAGGSLIfytFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRK-T 306
Cdd:cd17364 205 ------WFLLDIAFY---GQNLFQSTI---ISAIGFSKTMNAYQELFNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKkI 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 307 SMLWFGTLGtlctlpilLALKTVSSPY-MAFFLIILALAIVSLY--------TSISGLIKAEMFPPEVRALGVGVSYAVG 377
Cdd:cd17364 273 QMMGFFGMT--------IFLLILAGPYdHWKISTIGFFVLYGLTfffsnfgpNTTTFIVPAEVFPARVRSTCHGISAASG 344
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 489224681 378 N--AIFGGsaeYVALGL-KSVGMENVFyWYVSAMCLLALLV 415
Cdd:cd17364 345 KigAIVGS---FLFLSLtQNIGVRNVL-IILAGVALLGIIL 381
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
74-414 |
6.22e-14 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 72.99 E-value: 6.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 74 IGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTyasigtlaPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQ 153
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPN--------FTIFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 154 RGFFASFQYVTLIGGQLLAVLVVVILQQLLSEDELRAWGWRIPFVIGAITAVIALWLrrslnetasksTLERKESGTFAe 233
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLG-----------MLFIPESPRWL- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 234 LFKHKRAFFTVLGFTA-----GGSLIFYTFTTYMQKylvntAGMSAkTASAVMTFALFAYMLMQPLFGM-LSDRIGRKTS 307
Cdd:cd17359 191 VSKGKPILIIGIGLAIfqqfvGINVIFYYGPEIFQN-----AGFSE-NAALLQTIGIGVVNVIFTIIAIlLVDKVGRKPL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 308 MLWfGTLGTLCTLPIL-----LALKTVSSPYMAFFLIILALAIVSLYTS-ISGLIKAEMFPPEVRALGVGVSYAV---GN 378
Cdd:cd17359 265 LLI-GSIGMAISLLLIgtafyFAPGSQASGIVALVLILLFVAFFAMSWGpVTWVLLSEIFPNRIRGLAMGIAVFFlwiAN 343
|
330 340 350
....*....|....*....|....*....|....*.
gi 489224681 379 AIFGGSaeyVALGLKSVGMENVFYWYVsAMCLLALL 414
Cdd:cd17359 344 FLVSLT---FPILLAAFGLAFTFLIFA-VICVLAFL 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
68-415 |
3.42e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 68.00 E-value: 3.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 68 GFLMRPIGGWMFGRIADKHG-RKTAMLISVVMMCAGSLAIACMPTYASIGTLAPALLLLARMFQGLSVGgeygtSATYMS 146
Cdd:COG2211 59 DAITDPLIGALSDRTRTRWGrRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLV-----NIPYSA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 147 EVAL----KGQRGFFASFQYVTLIGGQLLAVLVVVILQQLLSEDElrAWGWRIPFVIGAITAVIA-LWLRRSLNETASKS 221
Cdd:COG2211 134 LGAEltpdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALIFAVLGLLAfLLTFFGTKERPVPE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 222 TLERKESGTFAELFKHkRAFFTVLGFTAGGSLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDR 301
Cdd:COG2211 212 EEKVSLKESLKALLKN-RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 302 IGRKTSMLWFGTLGTLCTLPILLAlkTVSSPYMAFFLIILALAIVSLYTSISGLIKAEMFPPE--------------VRA 367
Cdd:COG2211 291 FGKKKAFIIGLLLAALGLLLLFFL--GPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrreglyfgIFT 368
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 489224681 368 LGVGVSYAVGNAIFG---GSAEYVALGLKS----VGMENVFYWYVSAMCLLALLV 415
Cdd:COG2211 369 FAIKLGQALAGALAGlllALFGYVAGAAQSpsalTGIRLLFFLLPAVLLLLAALL 423
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
78-416 |
3.96e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 67.20 E-value: 3.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 78 MFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIGTLAPALLLLARMF--QGLSVGGEYGTS--ATYMSEVALKGQ 153
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFhpEGARLASQAAGGrrGLAMSIFSVGGN 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 154 RGFFASFQYVTLIggqllavlvvvilqqllsedeLRAWGWRIPFVIGAITAVI-ALWLRRSLNETASKSTLERKESGTFA 232
Cdd:cd17478 130 LGFALGPLIAAAL---------------------VALFGGLGLLILLIIPGLAvALLLLRLRPLKKPEAKKAAAKSSARS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 233 ELFKHKRAFFTVLGFTAGGSLIFYTFTTYMQKYLVNTaGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTsMLWFG 312
Cdd:cd17478 189 TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRR-VIIAS 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 313 TLGTlctlPILLALKTVSSPYMAFFLIILALAIVSLYTSISGLIKAEMFpPEVRALGVGVSYAVGNAIFGGSAEYVALGL 392
Cdd:cd17478 267 LLLA----APFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL-PGNVGLASGLMMGLSFGLGGIGAPVLGALA 341
|
330 340
....*....|....*....|....
gi 489224681 393 KSVGMENVFYWYVSAMCLLALLVC 416
Cdd:cd17478 342 DAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
44-382 |
5.01e-12 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 66.89 E-value: 5.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 44 FAPAFFPS----------------DNPTVQLLNT----AGVFAAGFLMRPIGGWmfgriadkhGRKTAMLISVVMMCAGS 103
Cdd:cd17361 25 FLEKFFPSvyekkkgasennyckyDDQLLQLFTSslylAGLVASLLASYVTRKW---------GRKPSMLIGGVLFLVGA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 104 LAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKGQRG-FFASFQYVTLIGgqllavlvvVILQQL 182
Cdd:cd17361 96 ALNAAAQNIAML--------IVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGaLNIGFQLAITIG---------ILIANL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 183 LS--EDELRAWGWRIPFVIGAITAVIALWLRRSLNETASKSTLE--------RKESGTFAELFkHKRAFFTVLGFTAGGS 252
Cdd:cd17361 159 INygTSKIKPNGWRLSLGLAAVPALILLLGSLFLPETPNSPQLViailipffQQLTGINVIMF-YAPVLFQTLGFGSDAS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 253 LIFYTFTtymqkylvntagMSAKTASAVMTFalfaymlmqplfgMLSDRIGRKTSMLWFGTLGTLC--TLPILLALKTVS 330
Cdd:cd17361 238 LISAVIT------------GAVNVVSTLVSI-------------YLVDRFGRRFLLLEGGVQMLASqvAIGILLAVKFGD 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 331 SPYMAFFLIILALAIVSLY--------TSISGLIKAEMFPPEVRALGVGVSYAVgNAIFG 382
Cdd:cd17361 293 GGELPKAYAIAVVVLICLYvaafawswGPLGWLVPSEIFPLETRSAGQSLTVAV-NFLFT 351
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
64-342 |
5.12e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.19 E-value: 5.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 64 VFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIGTLApallllarMFQGLSVGGEYGTSAT 143
Cdd:COG0738 48 LLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAL--------FLLGLGLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 144 YMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVILQQLLSedelraWGWRIPF-VIGAITAVIALWLRRS-LNETASKS 221
Cdd:COG0738 120 YVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLS------LSWHLPYlILAVLLLLLALLFLRSkLPEIEEEE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 222 TLERKESGTFAELFKHKRAFFTVLGFTAGGsLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDR 301
Cdd:COG0738 194 EEAAGSAASLKSLLKNPRLLLGGLAIFLYV-GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR 272
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 489224681 302 IGRKTSMLWFGTLGTLCTLPILLAlktvSSPYMAFFLIILA 342
Cdd:COG0738 273 FGPVRLLRLSALLAAVGLLLALLA----PGPWLALIGLALV 309
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
190-350 |
5.39e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 60.66 E-value: 5.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 190 AWGWRIPFVIGAITAVIALWLRRSLNETASKSTLERKESGTFAELFKHKRAFfTVLGFTAGGSLIFYTFTTYMQKYLVnT 269
Cdd:COG2807 167 ALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAW-LLTLFFGLQSLLYYAVVAWLPPILR-D 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 270 AGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAFFL-------IILA 342
Cdd:COG2807 245 AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLglgqgglFPLA 324
|
....*...
gi 489224681 343 LAIVSLYT 350
Cdd:COG2807 325 LTLIGLRA 332
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
74-421 |
6.60e-10 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 60.36 E-value: 6.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 74 IGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKGQ 153
Cdd:cd17360 50 VGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVL--------IVGRVLVGLGVGIASMTVPLYIAEAAPPRI 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 154 RGFFASFQYVTLIGGQLLAVLVVVILQQLLSedelrawGWRIPFVIGAITAVIALWLRRSLNETAS-KSTLERKESGTFA 232
Cdd:cd17360 122 RGRLVTINVLFITGGQFVAYVINGAFSYLPG-------GWRWMLGLAAVPAVLQFIGLLFLPESPRwPSTRRALIVGCGL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 233 ELFKHKRAFFTVLGFTAggsLIFYTFTTymqKYLVNTAGMSAKTASAVMTFALFAYMLMqplfgmlsDRIGRKTSMLW-- 310
Cdd:cd17360 195 QAFQQFSGINTVMYYSA---TILQMAGF---KDNQNAIWLSLIVAGTNFIFTIVGMYLI--------DKFGRRKLLLIsl 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 311 FGTLGTLCTLPILLALktvsspymaFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYA---VGNAIFggSAEY 387
Cdd:cd17360 261 FGVIVALVVLAVWLAL---------VGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAvnwVFNLLV--SQTF 329
|
330 340 350
....*....|....*....|....*....|....
gi 489224681 388 VALgLKSVGMENVFYWYVSAMCLLALLVCVSLPD 421
Cdd:cd17360 330 LTL-TQAIGPYGTFLLFAGLAVLGLIFIYFCVPE 362
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
61-423 |
6.62e-10 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 60.74 E-value: 6.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 61 TAGVFAAGFLmrpIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIacmptYASIGTLAPALLLLARMFQGLSVGGEYGT 140
Cdd:cd17357 54 IVSIFFIGGA---IGSFISAFLANRFGRKNGLLISNALLVVSSLLM-----FLSKSAKSPELLIFGRFLVGIACGLSTGF 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 141 SATYMSEVALKGQRGFFASFQYVTLIGGqlLAVLVVVILQQLLSEDELRAWGWRIPFVIGAITAVIALWLRRS------- 213
Cdd:cd17357 126 VPMYLQEISPSELRGALGSLTQIGVTLG--ILLGQVFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESpkfllis 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 214 -LNETASKSTLER------------------------KESGTFAELFKHK---RAFFTVLGFTAG------GSLIFYTFT 259
Cdd:cd17357 204 kGDEEEAEKSLKFlrgieddvdqeleeikkeseqmgdQKQVSLMQLLRDPslrLPLLLVLVVSASqqfsgiNAIFFYSTF 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 260 TYMQkylvntAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSS-PYMAFFL 338
Cdd:cd17357 284 IFEN------AGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQnSWMSYGC 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 339 IILALAIVSLYT----SISGLIKAEMFPPEVRALGVGVSYAV---GNAIFGgsaeYVALGLKSVGMENVFYWYVSAMCLL 411
Cdd:cd17357 358 IVAIFLFIFFFAiglgPIPWFIGAELFPQAPRSAAQSLGSSVnwtSNFIVG----MAFPPLQSIGGGFVFIIFAIPCALF 433
|
410
....*....|..
gi 489224681 412 ALLVCVSLPDLR 423
Cdd:cd17357 434 LLYLYRYLPETK 445
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
78-417 |
1.25e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 59.51 E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 78 MFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKGQR--- 154
Cdd:cd17473 54 LAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL--------LASRALLGIGVAGIMTLATALIGDYFEGEERakm 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 155 -GFFASFQYV-----TLIGGQllavlvvvilqqllsedeLRAWGWRIPFVIGAITAVIALWLRRSLNETASKSTlERKES 228
Cdd:cd17473 126 lGLQSAAMSLggvvfLLLGGA------------------LAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSK-SAASP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 229 GTFAELFKHKRAFFTVLGFTAGGSLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSM 308
Cdd:cd17473 187 GAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 309 LWFGTLGTLCtlpiLLALKTVSSPYMAFFLIILA-----LAIVSLYTSISGLIkaemfPPEVRALGVGVsyaVGNAIFGG 383
Cdd:cd17473 267 AIGFALMALG----FLLLALASGLWVVLLGAILAglgfgLLLPTLNSWAMSLV-----PPELRGRAMGI---VTSAFFLG 334
|
330 340 350
....*....|....*....|....*....|....*...
gi 489224681 384 SAEY----VALGLKSVGMENVFYWYVSAMCLLALLVCV 417
Cdd:cd17473 335 QFLSplvlGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
23-414 |
6.57e-09 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 57.20 E-value: 6.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 23 ASSGNLVEWFDFYVYAFCAIYFAPAFFPSDNPTVQLLNTAGVFAAGFlmrpIGGWMFGRIADKHGRKTAMLISVVMMCAG 102
Cdd:cd17315 2 AALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAA----IGSLFGGPLADRFGRRKSLLIAAVLYVIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 103 SLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVILQQL 182
Cdd:cd17315 78 ALLSALAPNVWVL--------IVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 183 LSedelraWGWRIPFVIGAITAVIALWLRRSLNETaskstlerkesgtfaelfkhkRAFFTVLG------FTAGGSLIFY 256
Cdd:cd17315 150 PP------GWWRLMFALAAVPALLQLLLMFFLPES---------------------RALLVGVGlqllqqLTGINAVMYY 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 257 TFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMlmqplfgMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAF 336
Cdd:cd17315 203 APTIFKSAGGGTASILASIIVGVVNLLATLVAI-------RLVDKVGRRPLLLIGFAGMAASLLLLAIAFLLPALAKAAG 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 337 FLIILALAIVSLYTSIS-----GLIKAEMFPPEVRALGVGVSYAV---GNAIFGGSAEYValgLKSVGMENVFYWYvSAM 408
Cdd:cd17315 276 WLALLGILLYIAAFAMGagpvpWLLLSEIFPLRIRGKGMAIATLVnwiFNFIVGLTFLIM---VSTIGLAGVFIFF-AAV 351
|
....*.
gi 489224681 409 CLLALL 414
Cdd:cd17315 352 CLLALV 357
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
62-350 |
7.59e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 57.18 E-value: 7.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 62 AGVFAAGFLmrpIGGWMFGRIADKHGRKTAMLisvVMMCAGSLAIACMPTYASIgtlapALLLLARMFQGLSVGGEYGTS 141
Cdd:cd17477 37 ASAYYLGIL---LGSPLVPRLIRRVGHIRAFA---AGAAITAVSVLLLALTDSP-----WVWFLLRFVMGIGLAGLFVVS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 142 ATYMSEVALKGQRG----FFASFQYVTLIGGQLLAVLVVVILQQllsedelrawgwriPFVIGAIT---AVIALWLRRSl 214
Cdd:cd17477 106 ESWLNALATNENRGrvlgLYSTVLGLGFALGPLLLALVGTAGAL--------------PFLIAAVLlllALVPLLLTRR- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 215 netaSKSTLERKESGTFAELFKhkRAFFTVLG-FTAGGSLIfyTFTTYMQKYLVNtAGMSAKTASAVMTFALFAYMLMQP 293
Cdd:cd17477 171 ----AAPEIEEAESISLRRLLR--IAPLALLGaFVAGFLEG--AFYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQW 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 489224681 294 LFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTvsSPYMAFFLIILALAIVSLYT 350
Cdd:cd17477 242 PLGWLADRFDRRRVLLGCALLGALAALLLPLVPGL--PLALLVLLFLWGGAAGPLYT 296
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
32-417 |
1.07e-08 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 56.96 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 32 FDFYVYAFCAIYFAPAF---FPSDNPTVQLLNTAGVFAAGFLM-RPIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIA 107
Cdd:TIGR00879 40 FGYDTGVIGGALALPAFefkFTSANSDSYSSSLWGLVVSIFLVgGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 108 CmptyaSIGTLAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVILQQLLSEDe 187
Cdd:TIGR00879 120 L-----AAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVSLNNTL- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 188 lrawGWRIPFVIGAITAVIAL-----------WLRRSLNETASKSTLERKESGT--------FAELFKHKRAFFTVLGFT 248
Cdd:TIGR00879 194 ----GWRIPLGLQLIPAGLLFlglfflpesprWLVGKGRVEEARKSLARLRGTSgedkelldELELIDIKRSIEKRSVQP 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 249 AGGSLiFYTFTTYMQK------------------------YLVNTAGMSAKTASaVMTFALFAY-MLMQPLFGMLSDRIG 303
Cdd:TIGR00879 270 SWGSL-FSSTRRIRRRlflgvvlqwfqqftginaimyyspTIFENAGVSTDHAF-LVSIIVGAVnFAFTFVAIFLVDRFG 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 304 RKTsMLWFGTLGTLCT---LPILLALKTVSSPYMAFFLIILALAIVSLY--TSISG---LIKAEMFPPEVRALgvGVSYA 375
Cdd:TIGR00879 348 RRP-LLLIGAAGMAIClfvLGILGASFVTGSSKSSGNVAIVFILLFIAFfaMGWGPvpwVIVSEIFPLSLRPK--GISIA 424
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 489224681 376 VGNAIFG----GSAEYVALGLKSVGmenVFYWYVSAMCLLALLVCV 417
Cdd:TIGR00879 425 VAANWLAnfivGFLFPTMLESIGVG---GVFIFFGGLNVLGLIFVY 467
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
73-420 |
2.14e-08 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 56.04 E-value: 2.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 73 PIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKG 152
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWML--------YLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 153 QRGFFASFQYVTLIGGQLLAVLVVVILqqllsedelrawGWRIPFVIGAITAVIAL-----------WL-RRSLNETASK 220
Cdd:cd17358 127 VRGALGSLNQLLVNIGILLGYVLGSFL------------PWRTLALIGAIPPVVFLillffipesprWLaKKGREEEAEK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 221 S------------------------TLERKESGTFAELFKHK--RAFFTVLGFTA----GGSlifYTFTTYMQKYLVNT- 269
Cdd:cd17358 195 SlqflrgkdadiskeaaeiqeelaeLEKEAKESSFSDLFQRKylKPLVIGLGLMLfqqlSGI---NAVIFYASSIFDEAg 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 270 AGMSAKTAsavmTFALFAYMLMQPLFGM-LSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAFFLIILALAIVSL 348
Cdd:cd17358 272 SGLDPNTA----TIIIGVVQVVGTLVATlLVDRLGRRPLLLVSAIGMGIGLLALGLYFYLQEHGALLSSVSWLPLVGLVI 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 349 YT--------SISGLIKAEMFPPEVRALGVGVSYAVGN-AIFGGSAEYVALGLkSVGMENVFyWYVSAMCLLALL-VCVS 418
Cdd:cd17358 348 YIisfsiglgPLPWVIMSEIFPAKIKGLAGSLVTLVNWlFAFIVTKTFPFLTL-AWGASGTF-WIFAGICGLALVfVLLF 425
|
..
gi 489224681 419 LP 420
Cdd:cd17358 426 VP 427
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
198-415 |
2.50e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 55.63 E-value: 2.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 198 VIGAITAVIALWLRRSLNETASKSTLERKESgtfaELFKHKRAFFTVLGFTAGGSLIFYTFTTYMqkYLVNTAGMSAKTA 277
Cdd:cd17370 163 AIPALLALLILLFVVKEYPRPPKLRKKSKKT----SLKKLPKAFWLYLLAVALFALGNFSFAFLI--LRAQELGLSAALI 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 278 SAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLwfgtLGTLCTLPILLALKTVSSPYMAFFLIILALAIVSLYTSISGLIK 357
Cdd:cd17370 237 PLLYALFNLVYALAAYPAGRLSDRIGRKKLLI----LGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAV 312
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 489224681 358 AEMFPPEVRALGVGVSYA-VGNAIFGGSAEYVALgLKSVGMENVFyWYVSAMCLLALLV 415
Cdd:cd17370 313 ADLVPAELRGTAYGLFNTvVGIGWLLASLIAGYL-WDLISPSAAF-LFSAVLALIALLL 369
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
56-419 |
4.58e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.88 E-value: 4.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 56 VQLLNTAGVFAAGFLMRPIGgwmfgRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLsvg 135
Cdd:cd17474 36 VGLLITAFTLPAAVLMPVAG-----VLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL--------LAGRALQGI--- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 136 GEYGTSATYMSEVAlkgqrGFFASFQYVTLIGGQLLAVLVVVILQQLLSeDELRAWGWRIPFVIGAITAVIALWLRRSLN 215
Cdd:cd17474 100 GAAGLGPLALTLIG-----DLFEGGERAKAMGLYEAALGLGIAVGPLLG-GLLAAISWRYPFFLLAALIPVAFLAILFLL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 216 ETASKSTLERKESGTFAELFKHKRAFFTVLGFTAG-GSLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPL 294
Cdd:cd17474 174 PEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFlYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 295 FGMLSD-RIGRKTSMLwfgtLGTLCTLPILLALKTVSSPYMAFFLIILALAIVSLY-TSISGLIkAEMFPPEVRALgvgV 372
Cdd:cd17474 254 VGRLLKkRFGARRILV----IGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNlPLLTTLV-TELAPEEERGT---A 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489224681 373 SYAVGNAIFGGSA--EYVALGLKSVGMENVFYWYVSAMCLLALLVCVSL 419
Cdd:cd17474 326 SSLYNFVRFLGQAvgPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
192-373 |
4.71e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.55 E-value: 4.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 192 GWRIPFVI-GAITAVIALWLRRSLNETASKSTLERKESGTFAELFKHKRAFFTVLGFTAGGSLIF--YTFTTYMQKYLVN 268
Cdd:cd17475 148 GWRAAFVVaGLVSILAAVLFWLFYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVApqFALLTFLLLFLHD 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 269 TAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIG---RKTSMLWFGTLgTLCTLPILLALKTVSSPYMAFFLIILALAI 345
Cdd:cd17475 228 HLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVITAAI-AAAALLVLSLLSPGTPLWLLVLLLILLGLF 306
|
170 180
....*....|....*....|....*...
gi 489224681 346 VSLYTSISGLIKAEMFPPEVRALGVGVS 373
Cdd:cd17475 307 AIGWNGLYLTLVAESAGPEQAGTALGLA 334
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
236-414 |
4.94e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.49 E-value: 4.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 236 KHKRAFFTVLGFTAGGSLIFYTFTT---YMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFG 312
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSnlsVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 313 TLGTLCTLPILLAlktvSSPYMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFGGSAEYVALGL 392
Cdd:COG2271 83 LLWGLATLLFGFA----TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL 158
|
170 180
....*....|....*....|..
gi 489224681 393 KSVGMENVFYWYVSAMCLLALL 414
Cdd:COG2271 159 AAFGWRAAFLILGLPGLLLALL 180
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
62-415 |
6.20e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.11 E-value: 6.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 62 AGVFAAG-FLMRPIGGWMfgriADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGT 140
Cdd:cd17319 44 ASAFFLGyALFQVPGGWL----LDRFGARKVLAVSMLLWSLFTALTGFATSLTSL--------YVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 141 SATYMSEVALKGQRGF----FASFQYV-TLIGGqllavlvvvilqqLLSEDELRAWGWRIPFVIGAITAVIALWLrrsln 215
Cdd:cd17319 112 AIKALAEWFPARERGRatglFNSGAPLgAAIGP-------------PLSGWLLLLFGWRWAFIIEGLLGLLLAVL----- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 216 etaskstlerkesgtfaELFKHKRAFFTVLGFtAGGSLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLF 295
Cdd:cd17319 174 -----------------WWFYLRQVWGLALGY-FGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 296 GMLSDRIGRKTSmLWFGTLGTLCTLPILLALKTVSSPYMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYA 375
Cdd:cd17319 236 GRLSDRLLRGAR-RLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINS 314
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 489224681 376 VGNaiFGGSAEYVALG--LKSVGMENVFYWYVSAMCLLALLV 415
Cdd:cd17319 315 GGN--LGGFVAPLLIGylVDATGSYTAAFLFLAAVALLAALL 354
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
271-380 |
1.74e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.94 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 271 GMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLAlktVSSPYMAFFLIILALAIvSLYT 350
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA---PSFALLLLARALAGLAH-GGFW 105
|
90 100 110
....*....|....*....|....*....|
gi 489224681 351 SISGLIKAEMFPPEVRALGVGVsYAVGNAI 380
Cdd:cd17324 106 AIAAAYAADLVPPEKRGRAIGL-VFSGLTL 134
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
55-417 |
2.31e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 52.58 E-value: 2.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 55 TVQLlnTAGVFAAGFLmrpIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYAsigtlapaLLLLARMFQGLSV 134
Cdd:cd17320 35 AVQL--TLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIE--------QLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 135 GGEYGTSATYMSEVaLKGQRgfFAS-FQYVT-----------LIGGQLlavlvvvilqqllsedeLRAWGWRIPFVI-GA 201
Cdd:cd17320 102 AAGSVVARAIVRDL-YSGAE--LAKiFSLLMmilaiapalapLLGGLL-----------------LLFFGWRAIFVFlAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 202 ITAVIALWLRRSLNETASKSTLERKESGT---FAELFKHKRAFFTVLgFTAGGSLIFYTFTTYMQKYLVNTAGMSAKTAS 278
Cdd:cd17320 162 LGLLLLLLVLLFLPETLPEEKRKPLLSSLlraYKRVLKNRRFLGYAL-ALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 279 AVMTFALFAYMLMQPLFGMLSDRIGRKtSMLWFGTLGTLCTLPILLALKTVSSPYMAFFLIILALAIVSLYTSISGLIKA 358
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPR-RLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 359 EMFPPEVRAlGVgVSYAVGNAIFGGSAEYVAL-GLKSVGMENVFYWYVSAMCLLALLVCV 417
Cdd:cd17320 320 ALEPFPHVA-GT-ASALLGFLQFLIGALAGALvGLLPNGTALPMGLLILVLGLLALLLLI 377
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
64-377 |
2.38e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 52.66 E-value: 2.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 64 VFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSAT 143
Cdd:PRK11551 55 AFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSL--------LVARLLTGVGLGGALPNLIA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 144 YMSEVALKGQRGFFASFQYVTL-IGGQLLAVLVVvilqqLLSEDElrawGWRIPFVIG-----AITAVIALWLRRSlNET 217
Cdd:PRK11551 127 LTSEAVGPRLRGTAVSLMYCGVpFGGALASVIGV-----LAAGDA----AWRHIFYVGgvgplLLVPLLMRWLPES-RAF 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 218 ASKSTLERKESGTFAELFKHKRAFFTVLGFTAggslifYTFTTYMQKYLVN-------TAGMSAKTASAVMTFALFAYML 290
Cdd:PRK11551 197 AQAAGAGKQRAPVLRALFGEGRATATLLLWIS------YFFTLIVLYFLLNwlpsllvGQGLSRSQAGLVQIAFNIGGAL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 291 MQPLFGMLSDRIG-RKTSMLWF-GTLGTLCTLPIllalkTVSSPYMAFFLIILALAIVSLYTSISGLiKAEMFPPEVRAL 368
Cdd:PRK11551 271 GSLLIGALMDRLRpRRVVLLIYaGILASLAALAA-----APSFAGMLLAGFAAGLFVVGGQSVLYAL-APLFYPTQVRGT 344
|
....*....
gi 489224681 369 GVGVSYAVG 377
Cdd:PRK11551 345 GVGAAVAVG 353
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
61-364 |
4.69e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 51.50 E-value: 4.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 61 TAGVFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASigtlapallllarMFQGLSVGGEYGT 140
Cdd:cd17355 40 ISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQ-------------LYLLWGLLGGGGA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 141 SATYMSEVALKGQRGFFAS----FQYVTLiGGQLLAVLVVVILQQLLSedelrAWGWRIPFVI------GAITAVIALWL 210
Cdd:cd17355 107 GTLAAVAFATVAAWWFERRrglaLGILTA-GGGLGSLVFLPLGAALIE-----AFGWRTALLVlallalLVLVPVLLLLR 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 211 RR--SLNETASKSTLERKESGTFAELFKHKRAFFTVLGFTAGGsLIFYTFTTYMQKYLVNtAGMSAktASAVMTFALFAY 288
Cdd:cd17355 181 RRpaDLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCG-FAVVGLIVHLVPYLAD-RGISP--AAAAVALALIGL 256
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489224681 289 MLM--QPLFGMLSDRIGRKTSMLWFGTLGTLCTLpiLLALKTVSSPYMAFFLIILALAIVSLYTSISGLIkAEMFPPE 364
Cdd:cd17355 257 FNIvgRLLSGWLGDRYSPRRLLAASYALRALGLA--LLLLLPFPPLALLLFAALFGLGWGATVPLTAALA-ARYFGAR 331
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
64-382 |
1.12e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.25 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 64 VFAAGFLMrpiggwMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSAT 143
Cdd:cd17321 42 LAFAALLL------LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL--------IAARALQGIGAAAIMPASLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 144 YMSEVALKGQR----GFFASFQYVT-----LIGGqllavlvvvilqqLLSEdelrAWGWRIPFVIGAITAVIALWLRRSL 214
Cdd:cd17321 108 LIAATFPGERRgralGLWGAVVGIGaalgpLLGG-------------LLLE----LFGWRWIFLINVPIGLVALLLARTF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 215 NetaskstlerkesgtfaelfkhkRAFFTVLGFTAGGSLIFYTFTTYMQKYLvntaGMSAKTASAVMTFALFAYMLMQPL 294
Cdd:cd17321 171 S-----------------------GAVLAAFLLGAALGGLLFLLPLYLQGVL----GYSPLQAGLALLPLALAMLVAAPL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 295 FGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAFFLIILALAIVSLYTSISGLIKAEMfPPEVRALGVGV-- 372
Cdd:cd17321 224 AGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSV-PKEKAGAASGIln 302
|
330
....*....|....*
gi 489224681 373 -----SYAVGNAIFG 382
Cdd:cd17321 303 tarqlGGALGVALLG 317
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
190-345 |
1.21e-06 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 50.38 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 190 AWGWRIPFVIGAITAVIALWLRRSLNETASKSTLERKES-GTFAELFKHKR-AFFTVLGFTAGGSliFYTFTTYMQKYLV 267
Cdd:TIGR00886 164 AWGWAFVIVPAGILLLPALLIFFVGADTPPGKPATGKLSfKEALKVFGNRHtWILALLYSVTFGS--FLGVSSIFAMLFK 241
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489224681 268 NTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSpYMAFFLIILALAI 345
Cdd:TIGR00886 242 DQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGS-LAAFIVLFVALFF 318
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
80-415 |
4.52e-06 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 48.50 E-value: 4.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 80 GRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFAS 159
Cdd:cd17362 60 GALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVL--------LVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVS 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 160 FQYVTLIGGQLLAVLVVVILQQLLsedelraWGWRIPFVIGAITAVI----ALWLRRSLNEtaSKSTLERKESGTFAELF 235
Cdd:cd17362 132 LKELFIVLGILLGYVSGYAFADVV-------GGWRYMYGLAAPPALLlgigMWFLPPSPRW--QGNYRKPLIIGLGLVLF 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 236 KHkrafftvlgFTAGGSLIFYTFTTYmqkylvNTAGMSAKTASAVMTFALFAYMLMQPLFGMLS-DRIGRKTsMLWFGTL 314
Cdd:cd17362 203 QQ---------ITGQPSVLYYAATIF------KSAGFSAASDATLVSVGLGVFKLLMTIVAVLLvDKLGRRP-LLLGGVS 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 315 GTLCTLpILLALKTVSSPYMAFFLIILALAIVSLYTS--------ISGLIKAEMFPPEVRALGVGVSYAVGnaiFGGSAe 386
Cdd:cd17362 267 GMVVSL-FLLAAYNLFVQMGPAGLAWLSLVALLLYVGayqisfgpISWLMVSEIFPLRVRGRAIALAVLVN---FGSNA- 341
|
330 340 350
....*....|....*....|....*....|...
gi 489224681 387 YVALGL----KSVGMENVFYWYvSAMCLLALLV 415
Cdd:cd17362 342 LVSLAFlplqELIGLPGTFLGF-GVIGVLALLF 373
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
19-223 |
4.77e-06 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 48.57 E-value: 4.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 19 AIVGASSGNLVEWFDFYVYAFCAIYFAPAFFPSDNPTVQLLNTAgVFAAGFLMRPIGGWMFGRIADKHGRKTAMLISVVM 98
Cdd:TIGR00887 17 AIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKGPLPSSVSAA-VNGSASIGTLAGQLFFGWLADKLGRKRVYGMELII 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 99 MCAGSLAIACMPTYASIGtlAPALLLLARMFQGLSVGGEYGTSATYMSEVALKGQRGFFAS----FQYVTLIGGQLLAVL 174
Cdd:TIGR00887 96 MIIATVASGLSPGSSPKS--VMATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAavfaMQGFGILAGAIVALI 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 175 VVVILQQLL----SEDELRA-------WGWRIPFVIGAITAVIALWLRRSLNETASKSTL 223
Cdd:TIGR00887 174 VLAGFKHSLeaaaDEASCTGscvpavdYMWRILIGFGAVPALLALYFRLTIPETPRYTAD 233
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
241-432 |
2.24e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.42 E-value: 2.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 241 FFTVLGFTAGGSLIFYTFTTYMQKYlvntaGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTL 320
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESL-----GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 321 PILLAlktvSSPYMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNAIFGGSAEYVALGLKSVGMENV 400
Cdd:cd17325 77 LFAFA----TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAP 152
|
170 180 190
....*....|....*....|....*....|..
gi 489224681 401 FYWYVSAMCLLALLVCVSLPDLRKVSYLNDEP 432
Cdd:cd17325 153 FLVCAALALLALVLALLLLPEPRPPPNKRAVS 184
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
197-419 |
2.69e-05 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 45.96 E-value: 2.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 197 FVIGAITAVIALWLRRslnETASKSTLERKESGTFAELFKHKRAFFTVLGFTAGG------SLIFYTFTTYMQKYLVNTA 270
Cdd:cd17337 163 LVFVALGGLIALFLVR---DRTGEQPLANPSEEPLKELLSGITILFRNPKIAIGGivriinTLSQFGFPVFMPLYFTDTG 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 271 GMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAFFLIILAL--AIVSL 348
Cdd:cd17337 240 GFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWFGGVGCAISTLLFYYVPQLFGHNYWAALIAAILfgIGLAG 319
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489224681 349 YTSISGLIKAEMfpPEVRA-------LGVGVSYAVGNAIfggsaeyVALGLKSVGMENVFyWYVSAMCLLALLVCVSL 419
Cdd:cd17337 320 FVPLSALMPSLA--PEHKGaamsilnLGAGLSNFVGPAI-------VTLFLGSFGAGGVV-WIFAGLYLLSAVLTLFL 387
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
282-385 |
2.87e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 46.07 E-value: 2.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 282 TFALFaYMLMQPLFGMLSDRIGRKTSMlwfgTLGTLCTLPILLALKTVSSpymaFFLIILALAIV----SLYTSISGLIK 357
Cdd:cd17328 42 VFIIS-YMVLSPIFGYLGDRYNRKWIL----AVGILIWSAATLLSSFAPN----FWQLLLFRALVgigeASYSPIAPTII 112
|
90 100
....*....|....*....|....*...
gi 489224681 358 AEMFPPEVRALGVGVSYAvgnAIFGGSA 385
Cdd:cd17328 113 ADLFPKEKRTRALGVFYF---AIPLGSG 137
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
192-345 |
3.03e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 46.09 E-value: 3.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 192 GWRIPF---VIGAITAVIALWLRRSLNETASKSTLERkeSGTFAELFKHKRAFFTVL--GFTAGGsliFYTFTTYMQKYL 266
Cdd:cd17341 158 GWRNAFfvpGILLAIAAVLVLLFGDDLPTGKASALEF--LKVQLAVLKNYRTWILSLlyGVTFGS---FVGFSNVLPTYF 232
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489224681 267 VNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAFFLIILALAI 345
Cdd:cd17341 233 KTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGL 311
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
60-425 |
3.05e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 46.16 E-value: 3.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 60 NTAGVFAAGFLmrpIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYG 139
Cdd:TIGR00898 131 LTQSCFFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVF--------LVFRLLVGMGIGGIWV 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 140 TSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVILQQllsedelrawgWR-------IPFVIGAITAVI----AL 208
Cdd:TIGR00898 200 QAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD-----------WRwlqlavsLPTFLFFLLSWFvpesPR 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 209 WLRRSLNETASKSTLER-------------------------KESGTFAELF---KHKRAFFTVLGFTAGGSLIFYTFTT 260
Cdd:TIGR00898 269 WLISQGRIEEALKILQRiakingkklpaevlslslekdlsssKKQYSFLDLFrtpNLRKTTLCLMMLWFTTAFSYYGLVL 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 261 YMQKYLVNtagmsaktasAVMTFALFAYMLMQPLFG--MLSDRIGRKTSMLWFGTLGTLCTLPILLAlktvssPYMAFFL 338
Cdd:TIGR00898 349 DLGNLGGN----------IYLDLFISGLVELPAKLItlLLIDRLGRRYTMAASLLLAGVALLLLLFV------PVDLYFL 412
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 339 IIlALAIVSlYTSISG------LIKAEMFPPEVRALGVGVSYAVgnAIFGG--SAEYVALGLKSVGMENVFYwyvSAMCL 410
Cdd:TIGR00898 413 RT-ALAVLG-KFGITSafqmvyLYTAELYPTVVRNLGVGVCSTM--ARVGSiiSPFLVYLGEKWLFLPLVLF---GGLAL 485
|
410
....*....|....*
gi 489224681 411 LALLVCVSLPDLRKV 425
Cdd:TIGR00898 486 LAGILTLFLPETKGV 500
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
64-394 |
5.21e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 45.30 E-value: 5.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 64 VFAAGF-LMRPIggwmFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSA 142
Cdd:cd17328 42 VFIISYmVLSPI----FGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQL--------LLFRALVGIGEASYSPIAP 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 143 TYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVILQQLlsedeLRAWGW--RIPFVIGAITAVIALWL-----RRSLN 215
Cdd:cd17328 110 TIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQA-----TGGWRWafRVTGVLGVLLAILLLLFvreppRGAAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 216 ETASKSTLERKESGTFAELFKHKRAFFTVLGFTA----GGSLIFyTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLM 291
Cdd:cd17328 185 GGVMAKSTATSFLADLKALAKNPSFILSTLGFTAvsfvTGALAF-WAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 292 QPLFGMLSDRIGRKTSM--LWFGTLGTLCTLPILLA--LKTVSSPYMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRA 367
Cdd:cd17328 264 VLLGGILADRLRRKTPRadPLVCAVGLLAAAPFLFLalVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRS 343
|
330 340
....*....|....*....|....*..
gi 489224681 368 LGVGVsYAVGNAIFGGSAEYVALGLKS 394
Cdd:cd17328 344 TASAI-QILLSHLLGDAGSPYLIGLIS 369
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
74-415 |
5.77e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.91 E-value: 5.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 74 IGGWMFGRIADKHGRKTAMLISVVMMCAG--SLAIACMPTYASIGTLAPAllllarMFQGLSvggeYGTSATYMSEVALK 151
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGfaLLGFAHSPWLFAIALVLTG------FGGGLF----EPASEAMIADVTTP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 152 GQRGFFASFQYV---------TLIGGQllavlvvvilqqllsedeLRAWGWRIPFVIGAITAVI-ALWLRRSLNETASKS 221
Cdd:cd17329 120 ENRTRAFSLLYWainlgvaigPLLGGL------------------LLLYSFRLLFLAAAVLFLLaALVLLFLLPETRPKR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 222 TLERKESGTFA-ELFKHKRAFFTVLGFTAGGSLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSD 300
Cdd:cd17329 182 RAAEKTEILRGyKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVE 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 301 RIGRKTSMLWFGTLGTLCTLPILLALktvSSPYMAFFLIILALAIVsLYTSISGLIKAEMFPPEVR-------ALGVGVS 373
Cdd:cd17329 262 RFRLRKILMIGILLFAIGFAVLAFAN---TLAVLILAMIVLTLGEM-LVFPAVQTLVAALAPPDKRgsymgfyALAWGLG 337
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 489224681 374 YAVGNAIFGGSAEYVALGLksvgmenvFYWYVSAMCLLALLV 415
Cdd:cd17329 338 RAIGPLVGGLLLDLLGPGL--------PWLILAALGLIAAAL 371
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
277-416 |
6.05e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.88 E-value: 6.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 277 ASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLpiLLALktvsSPYMAFFLIILALAIVSL--YTSISG 354
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGV--LSAF----SPSYELFLVLRFLVGVTSagIFTVGF 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489224681 355 LIKAEMFPPEVR---ALGVGVSYAVGNAIFGGSAE--------YVALGLKSVGMenVFYWYVSAMCLLALLVC 416
Cdd:cd17317 101 VLGMEIVGPKYRsfvGILFGLFWALGYMLLALLAYlirdwrwlQLAISLPGLLF--LLLLWWLPRRTIIVGLI 171
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
55-377 |
6.40e-05 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 44.93 E-value: 6.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 55 TVQLLNTAGVFAAGFLMrpiGGWMFGRIADKHGRKTAMLISVVMMCAGslAIACMPTYASIGtlapaLLLLARMFQGLSV 134
Cdd:cd17356 44 SSRQGLIVSIVNLGSFF---GALISSFLSDRIGRKKSIQIGCVIYIIG--AIIQVAAIGKWY-----QLIVGRIIAGLGV 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 135 GGEYGTSATYMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVILQQLLSedelRAWgWRIPFVIGAITAVIALWLRRSL 214
Cdd:cd17356 114 GFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDG----SAQ-WRIPLGLQIVWGLLLLIGMFFL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 215 NEtaSKSTLERKESGTFAELFKHkrafftvlgfTAGGSLIFYTFTTYMQKylvntAGMSAKTASAVMTFALFAYMLMQPL 294
Cdd:cd17356 189 PE--SPRWLYRTILGIMLQLFQQ----------LTGINYFFYYGTTIFQS-----TGLTGSSPLLTSIILYIVNFVSTIP 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 295 FGMLSDRIGRKTSMLWFGTLGTLCTL-------------PILLALKTVSSPYMAFFLIILALAIVSLYTSISGLIKAEMF 361
Cdd:cd17356 252 GLFFVDKFGRRTCLLIGAAGMSICLFiyaavgvrylipnPQSGTSNKSAGNGMIVFICLFIFSFATTWGPIAWVYVAEVF 331
|
330
....*....|....*.
gi 489224681 362 PPEVRALGVGVSYAVG 377
Cdd:cd17356 332 PLRVRSKGMALATAFN 347
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
190-351 |
2.27e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 42.95 E-value: 2.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 190 AWGWRIPFVIGAITAVIAL--WLRRSLNETASKSTLERKESGTfaeLFKHKRAFFtVLGFTAGGSLIFYTFTTYMQKYLV 267
Cdd:cd17339 149 GGGWRGALAIWALPALLALliWLPQLRRRKRAAAAAAPLTKIS---VWRSPLAWQ-VTLFMGLQSLLFYTLMAWLPTILI 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 268 NtAGMSAKTASAVmtfaLFAYMLMQPLFGM----LSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAFFL----- 338
Cdd:cd17339 225 D-AGLSAATAGWL----LSLFQLVGIPASLlvpiLATRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLLglggg 299
|
170
....*....|....*
gi 489224681 339 --IILALAIVSLYTS 351
Cdd:cd17339 300 aaFSLALTLISLRSS 314
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
74-416 |
2.76e-04 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 42.91 E-value: 2.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 74 IGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSVGGEYGTSATYMSEVALKGQ 153
Cdd:cd17372 49 IGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWL--------IILRCLVGLGLGGGPQLASWYLEFLPAKSR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 154 RGFFASFQYVTLIGGQLLAVLVVVILQQLlsedelrawGWRIPFVIGAITAVIALWLRRSLnetaSKSTLErkesgTFAE 233
Cdd:cd17372 121 GTWMVLFSVFWTVGTIFEASLAWLVMPRL---------GWRWLLAFSSVPSSLLLVFYRWT----PKTTLL-----LWVI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 234 LFKHKRAFFTVLGFTA---------GGSLIFYTFTTYMQKYLVNTAGMSAKTasavMTFALFAYMLMQPLFGMLSDRIGR 304
Cdd:cd17372 183 WFGNAFAYYGVVLLTTelnnshnvcGSKSDSDSGESPTEKQCRNSNDVDYRD----VFIATFAEFPGLLISAAMIDRLGR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 305 KTSMlwfgTLGTLCTLPILLALKTVSSPYMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNaIFGGS 384
Cdd:cd17372 259 KASM----ASMLFTCCIFLLLLLICQSPFILTVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGR-IGAIL 333
|
330 340 350
....*....|....*....|....*....|..
gi 489224681 385 AEYVALGLKSVGMENVFYWYVSAMCLLALLVC 416
Cdd:cd17372 334 CPFIAQVLVHGSQTIALLLFSVVCLVSAICVC 365
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
244-379 |
2.87e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.98 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 244 VLGFTAGGSLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWfgtlGTLCTLPIL 323
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLA----GLLLRALGF 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 489224681 324 LALKTVSSPYMAFFLIILALAIVSLYTSISGLIKAEMFPPEVRALGVGVSYAVGNA 379
Cdd:cd17329 80 ALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINL 135
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
190-328 |
4.65e-04 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 42.18 E-value: 4.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 190 AWGWRIPF-VIGAITAVIALWLRRSLnetaskSTLERKESGTFA---ELFKHKRA----FFTVLGFTAggsliFYTFTTY 261
Cdd:PRK03545 159 YLGWRTTFlAIGGGALITLLLLIKLL------PLLPSEHSGSLKslpLLFRRPALvslyLLTVVVVTA-----HFTAYSY 227
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489224681 262 MQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRigRKTSMLWFGTLGTLCTLPILLALKT 328
Cdd:PRK03545 228 IEPFVQQVAGLSENFATLLLLLFGGAGIIGSVLFSRLGNR--HPSGFLLIAIALLLVCLLLLLPAAN 292
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
64-336 |
1.08e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.04 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 64 VFAAGFLMRPIGGWmfgrIADKHGRKTAMLISVVMMCAGSLAiacMPTYASIgtlapALLLLARMFQGLSVGGEYGTSAT 143
Cdd:cd17489 40 FTLAALLARPFAGR----LLDRFGRKRLLLIGLLIFALATLL---YLLATSV-----ALLLVLRLIHGIGWGAFTTAAAT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 144 YMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVILQQllsedelrAWGWRIPFVIGAITAVIALWLRRSLNETASKSTL 223
Cdd:cd17489 108 LVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ--------HLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 224 ERKESGTFAELFKHKRAFFTVLGFtAGGSLIFYTFTTYMQKYLVNTagmSAKTASAVMTFALFAYMLMQPLFGMLSDRIG 303
Cdd:cd17489 180 EAEAGTRAFRRLVEKKVLPPALIL-FLASIAYGAISTFLPLYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSDRKG 255
|
250 260 270
....*....|....*....|....*....|...
gi 489224681 304 RKTSMLWFGTLGTLCtlpiLLALKTVSSPYMAF 336
Cdd:cd17489 256 PKTVIIPGLLLLALG----LLLLSFAGSPWMLL 284
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
252-325 |
1.12e-03 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 41.08 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 252 SLIFYTFTTYMQKYLVNTA--------GMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSML----WFGtlgtLCT 319
Cdd:PRK15402 17 CLVLFEFATYIANDMIQPGmlavvedfNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLagvaFFI----LTC 92
|
....*.
gi 489224681 320 LPILLA 325
Cdd:PRK15402 93 LAILLA 98
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
271-421 |
1.30e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 40.80 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 271 GMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTlpiLLALKTVSSPYMAFFLIILALAIVSLYT 350
Cdd:TIGR00895 48 GLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT---LLCALATNVTQLLILRFLAGLGLGGLMP 124
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489224681 351 SISGLIkAEMFPPEVRALGVGVsYAVGNAIFGGSAEYVALGLKSV-GMENVFYWYVSAMCLLALLVCVSLPD 421
Cdd:TIGR00895 125 NLNALV-SEYAPKRFRGTAVGL-MFCGYPIGAAVGGFLAGWLIPVfGWRSLFYVGGIAPLLLLLLLMRFLPE 194
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
265-342 |
1.31e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.62 E-value: 1.31e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489224681 265 YLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKtsmlWFGTLGTLCTLPILLALKTVSSPYMAFFLIILA 342
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRR----YLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
241-421 |
2.30e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.88 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 241 FFTVLGFTAggsliFYTFTTYMQKYLVNTAGmSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLwFGTLgtLCTL 320
Cdd:cd17489 3 LANFFFFLS-----FYLLLPVLPLYAHDLGG-SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLL-IGLL--IFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 321 PILLALKTVSSPYMAFFLIILALAIVSLYTSISGLIkAEMFPPEVRALGVG---VSYAVGNAIFGGsaeyVALGLKSVGM 397
Cdd:cd17489 74 ATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLV-ADIIPPSRRGEGIGyygLATTLAMALGPA----LGLFLYQHLG 148
|
170 180
....*....|....*....|....
gi 489224681 398 ENVFYWYVSAMCLLALLVCVSLPD 421
Cdd:cd17489 149 FAVLFIVAAVLALLALLLVFLVKD 172
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
236-379 |
3.47e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.02 E-value: 3.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 236 KHKRAFFTVLGFTAGGSLIFYTFTTY--MQKYLVNTAGMSAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGT 313
Cdd:COG0477 8 PTRRRRRALLALALGTFLEGLDFTIVnvALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489224681 314 LGTLCTLPILLAlktVSSPYMAFFLIILALAIVSLYTSISGLIkAEMFPPEVRALGVGVSYAVGNA 379
Cdd:COG0477 88 LFGLASLLCGLA---PSPELLIAARALQGIGAGGLMPGALALI-AELFPARERGRALGLWGAAIGL 149
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
261-391 |
7.24e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.32 E-value: 7.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 261 YMQKYLVNTAGMSAKTASAVMTFALFAYMLMqplfGMLSDRIGRKTSMLWFGTLGTLCTlpILLALKTvSSPYMAFFLII 340
Cdd:cd17359 26 FLQTDFNLTPFLEGLVVSSALLGAAIGALFA----GRLADRFGRRKTLLISAVLFFISA--LGSAFSP-NFTIFIIARII 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489224681 341 LALAiVSLYTSISGLIKAEMFPPEVRA-----------LGVGVSYAVgNAIFGGSAEYVALG 391
Cdd:cd17359 99 GGLA-VGGASALVPMYIAEVAPAEIRGrlvslnqlmivFGQLLAYIV-NYLIANAGGADWLG 158
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
55-372 |
8.39e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.33 E-value: 8.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 55 TVQLLNTAGVFAAGfLMRPIGGWmfgrIADKHGRKTAMLISVVMMCAGSLAIACMPTYASIgtlapallLLARMFQGLSV 134
Cdd:cd17503 32 TVQWVITSYLLALA-IMIPLSGW----LADRFGTRRLFLTALALFTLGSLLCGLAPNLASL--------IIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 135 GGEYGTSATYMSEVALKGQRGFFASFQYVT---------LIGGqllavlvvvilqqLLSEdelrAWGWRIPFVIGAITAV 205
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVillapaigpTLGG-------------WLTD----NLSWRWIFYINLPIGI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 206 IALWLRRSLNetaskstlerkesgtfAELFKHkRAFFTVLGFTAGGSLIFYTFTTYMQKYLVNTAGMSAKTASAVMTFAL 285
Cdd:cd17503 162 LALLLAPLLD----------------LRLFKD-RNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 286 FAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAFFLIILALAIVSLYTSISGLIKAEMfPPEV 365
Cdd:cd17503 225 LASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSL-PPEQ 303
|
....*..
gi 489224681 366 RALGVGV 372
Cdd:cd17503 304 IGDATAL 310
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
273-420 |
8.72e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 37.98 E-value: 8.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 273 SAKTASAVMTFALFAYMLMQPLFGMLSDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAFFLIILALAIVS-LYTS 351
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASaFFGP 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 352 ISGLIKAEMFPPEVRALGVGVSYAVGN-AIFGGSAeyVALGLKSVGMENVFYWYVSAMCLLALLVCVSLP 420
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQlARIIGPA--LGGLLVALLGPGGAFAINALSFLLSALLLLFIR 179
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
64-414 |
8.94e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 37.95 E-value: 8.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 64 VFAAGFLmrpIGGWMFGRIADKHGRKTAMLISVVMMCAGSLAIACMPTYASigtlapalLLLARMFQGLSVGGEYGTSAT 143
Cdd:cd17317 33 IFFLGVL---IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL--------FLVLRFLVGVTSAGIFTVGFV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 144 YMSEVALKGQRGFFASFQYVTLIGGQLLAVLVVVILQQllsedelrawgWRIPFVIGAITAVIALWLRRSLnetaSKSTL 223
Cdd:cd17317 102 LGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD-----------WRWLQLAISLPGLLFLLLLWWL----PRRTI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 224 erkesgtfaelfkhkraFFTVLGFTAggSLIFYTFTTYM-----QKYLvNTAGMSAKTASAVmtfaLFAYMLMqplfgml 298
Cdd:cd17317 167 -----------------IVGLIWFVT--SLVYYGLSLNSsnlggNLYL-NFFLSGLVEIPAY----FLALLLL------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489224681 299 sDRIGRKTSMLWFGTLGTLCTLPILLALKTVSSPYMAFFLII-----LALAIVSLYTSisglikaEMFPPEVRALGVGVS 373
Cdd:cd17317 216 -DRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGkfaisAAFSVIYLYTA-------ELYPTVVRNTGVGLC 287
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 489224681 374 YAVGNaIFGGSAEYVALglksvgmENVFYWYVSA--MCLLALL 414
Cdd:cd17317 288 STVAR-VGAILAPFIVL-------LGKIGPLLPLiiFGVLALL 322
|
|
| |
