|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
18-412 |
3.49e-97 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 297.17 E-value: 3.49e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMGNIVADLGSFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIA 97
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 98 QTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGI 177
Cdd:cd17502 81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 178 LSLFFIlryykeslehkkqkidwagaitlvvsivglmfalelggktydwnsvqiiglfavfavffiaffiverkaeepii 257
Cdd:cd17502 161 LALALL-------------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 258 sfwmfknRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTK-VRFRNLMLI 336
Cdd:cd17502 167 -------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKtGRYKPLIVI 239
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489248481 337 SVVAFFIGMLLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTI 412
Cdd:cd17502 240 GTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
13-494 |
3.74e-67 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 224.18 E-value: 3.74e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 13 FVVIGLLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGS 91
Cdd:TIGR00711 2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGsSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 92 ALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYI 171
Cdd:TIGR00711 82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 172 NVPIGILSLFFILRYYKESLEHKKQKIDWAGAITLVVSIVGLMFALELGGKTYDWNSVQIIGLFAVFAVFFIAFFIVERK 251
Cdd:TIGR00711 162 NVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWELT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 252 AEEPIISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFR 331
Cdd:TIGR00711 242 DDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 332 NLMLISVVAFFIGM-LLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGV 410
Cdd:TIGR00711 322 KLVTIGLILYAVGFyWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGT 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 411 TIFGTIQTN---VFTNKLTDSFSGMKGAGGAMQNIGNPQEIFQAGTRAHIPPHILdriIDAMSQSITYVFTLALAPIVIA 487
Cdd:TIGR00711 402 ALITTILTNrtqFHHSQLTETINPVNPNFLSGYSQLAALGNPEQQVYALIAQQIT---LHAFSIAINEIFWMATLLFVSG 478
|
....*..
gi 489248481 488 AVTILFM 494
Cdd:TIGR00711 479 LILIWFL 485
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
18-428 |
3.74e-64 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 212.80 E-value: 3.74e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGI 96
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGaSPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 97 AQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIG 176
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 177 ILSLFFIlryykeslehkkqkidwagaitlvvsivglmfalelggktydwnsvqiiglfavfavffiaffiverkaeepi 256
Cdd:cd17321 161 LVALLLA------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 257 isfwmfknRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLI 336
Cdd:cd17321 168 --------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 337 SVVAFFIGMLLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFGTI 416
Cdd:cd17321 240 GLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
410
....*....|..
gi 489248481 417 QTNVFTNKLTDS 428
Cdd:cd17321 320 LTAGLSANLGDS 331
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
18-423 |
2.77e-63 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 210.90 E-value: 2.77e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGI 96
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGaSLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 97 AQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIG 176
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 177 ILSLFFIlryykeslehkkqkidwagaitlvvsivglmfalelggktydwnsvqiiglfavfavffiaffiverkaeePI 256
Cdd:cd17503 161 ILALLLA-----------------------------------------------------------------------PL 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 257 ISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLI 336
Cdd:cd17503 170 LDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLA 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 337 SVVAFFIGMLLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFGTI 416
Cdd:cd17503 250 GLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329
|
....*..
gi 489248481 417 QTNVFTN 423
Cdd:cd17503 330 LTNRTQF 336
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-408 |
9.44e-52 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 179.40 E-value: 9.44e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 5 AAKDASTKFVVIGLLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFG 83
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 84 LILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSI 163
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 164 SWHWVFYINVPIGILSLFFILRYYKESLEHKKQKIDWAgaitlvvsivglmfalelggktydwnsvqiiglfavfavffi 243
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS------------------------------------------ 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 244 affiverkaeepiiSFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGI 323
Cdd:COG2814 200 --------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGR 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 324 FQTKVRFRNLMLISVVAFFIGMLLLSNMTPDtarTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRS 403
Cdd:COG2814 266 LADRFGRRRLLLIGLLLLALGLLLLALAGSL---WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342
|
....*
gi 489248481 404 FGMTL 408
Cdd:COG2814 343 LGGPL 347
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
30-495 |
4.07e-46 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 168.57 E-value: 4.07e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 30 TIVATAMGNIVADLGSFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVI 109
Cdd:cd06179 15 TLPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 110 QGIGGGALmPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLG--ALITDSISWHWVFYINVPIGILSLFFILRYY 187
Cdd:cd06179 95 IGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAgaLVEANAAGWRWIFYINAIFNALALILLFFFY 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 188 K---------ESLEHKKQKIDWAGAITLVVSIVGLMFALELGGKTYDWNSVQIIGLFAVFAVFFIAFFIVERKA--EEPI 256
Cdd:cd06179 174 HppprpqlhgSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHVIAPLVIGGVLLIAFGLYEWKGtkDGLL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 257 ISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVR-FRNLML 335
Cdd:cd06179 254 PPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKhIKWQLV 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 336 ISVVAFFIGMLLLSNMTPDTARTMLtVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFGT 415
Cdd:cd06179 334 AGFVLFTAFLALLALITPDNKALAI-AFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGTAIFTS 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 416 IQTNVFTNKLTDSFSG-------------------MKGAGGAMQNI-GNPQEIFQAGTRAhipphildrIIDAMSQSITY 475
Cdd:cd06179 413 ILSNRLSKNLPARVAPaaleaglpasslpallgalASGNIAALTAVpGINPEIIAAATAA---------LKQAYADSFRY 483
|
490 500
....*....|....*....|
gi 489248481 476 VFTLALAPIVIAAVTILFMG 495
Cdd:cd06179 484 VWYAAIPFGVVAIIAALFLR 503
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
18-434 |
2.14e-40 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 149.65 E-value: 2.14e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGI 96
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGtSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 97 AQTMDQLIIYRVIQGIGGGALmPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIG 176
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 177 ILSLFFIlryykeslehkkqkidwagaitlvvsivglmfalelggktydwnsvqiiglfavfavffiaffiverkaeePI 256
Cdd:cd17504 160 VLLAALV-----------------------------------------------------------------------PL 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 257 ISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQ----AVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRN 332
Cdd:cd17504 169 IDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRR 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 333 LMLISVVAFFIGMLLLsnMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTI 412
Cdd:cd17504 249 VLLIGLVISAVGLLLL--ALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAI 326
|
410 420
....*....|....*....|..
gi 489248481 413 FGTIQTNVFTNKLTDSFSGMKG 434
Cdd:cd17504 327 AGAILTTYTVSITSGGVPTEGA 348
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-292 |
2.72e-38 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 141.87 E-value: 2.72e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 2 EQTAAKDASTKFVVIGLLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFF 80
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGaSSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 81 LFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALIT 160
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 161 DSISWHWVFYINVPIGILSLFFILRYYKESLEHKKQKIDWAGAITLVVSIVGLMFALELGGKTYDWNSVQIIGLFAVFAV 240
Cdd:COG0477 163 AALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLL 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 489248481 241 FFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFV 292
Cdd:COG0477 243 LALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
15-414 |
3.55e-32 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 126.92 E-value: 3.55e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 15 VIGLLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSAL 93
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGaSPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 94 CGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDsISWHWVFYInV 173
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFL-L 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 174 PIGILSLFFILRYYKESLEHKKQKIDwagaitlVVSIVGLMFAlelggktydwnsvqiiglfavfavffiaffiverkae 253
Cdd:cd17474 159 AALIPVAFLAILFLLPEPKEKAKSSS-------ATKLRDLKKA------------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 254 epiisfwmFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGG-IFQTKVRFRN 332
Cdd:cd17474 195 --------LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARR 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 333 LMLISVVAFFIGMLLLSNMtpdTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTI 412
Cdd:cd17474 267 ILVIGLLLYALSLLLLGFV---PSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLL 343
|
..
gi 489248481 413 FG 414
Cdd:cd17474 344 FG 345
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
21-414 |
8.93e-31 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 124.46 E-value: 8.93e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 21 GILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQT 99
Cdd:PRK10504 18 GFFMQSLDTTIVNTALPSMAQSLGeSPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 100 MDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRgkMSGM-FGAVFG-LSSVLGPLLGALITDSISWHWVFYINVPIGI 177
Cdd:PRK10504 98 LNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQY--MAAMtFVTLPGqVGPLLGPALGGLLVEYASWHWIFLINIPVGI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 178 ---LSLFFILRYYKesleHKKQKIDWAGAITLVVSIVGLMFALElGGKTYDWNSVQIIGLFAVFAVFFIAFFIVERKAEE 254
Cdd:PRK10504 176 igaIATLMLMPNYT----MQTRRFDLSGFLLLAVGMATLTLALD-GSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 255 PIISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVigSMIGGIFQTKVRF--RN 332
Cdd:PRK10504 251 ALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSM--GMKRIVVQVVNRFgyRR 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 333 LMLISVVAFFIGMLLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTI 412
Cdd:PRK10504 329 VLVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTI 408
|
..
gi 489248481 413 FG 414
Cdd:PRK10504 409 AG 410
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-409 |
1.13e-29 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 119.06 E-value: 1.13e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMGNIVA-DLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCG 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAeDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 96 IAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPI 175
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 176 GILSLFFILRYYKESLEHKKqkidwagaitlvvsivglmfalelggktydwnsvqiiglfavfavffiafFIVERKAEEP 255
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRP--------------------------------------------------KPAEEARLSL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 256 IISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQaVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLML 335
Cdd:pfam07690 191 IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489248481 336 ISVVAFFIGMLLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLG 409
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
15-412 |
1.67e-29 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 119.22 E-value: 1.67e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 15 VIGLLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSAL 93
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGaSASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 94 CGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINV 173
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 174 PIGILSLFFILRYYKESLEHKKQKIDWAGAITLVVSIvglmfalelggktydwnsvqiiglfavfavffiaffiverkae 253
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRV------------------------------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 254 epiisfwmFKNRLFataQILAFLYGATFVILAVFI---PIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRF 330
Cdd:cd17320 198 --------LKNRRF---LGYALALGLSFAGLFAYLaaaPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGP 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 331 RNLMLISVVAFFIG--MLLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMnDLEPRYRGSANSTNSFLRSFGMTL 408
Cdd:cd17320 267 RRLLRLGLLLLLAAalVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLAL-EPFPHVAGTASALLGFLQFLIGAL 345
|
....
gi 489248481 409 GVTI 412
Cdd:cd17320 346 AGAL 349
|
|
| MFS_efflux_LmrB |
NF000060 |
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters ... |
3-499 |
1.87e-29 |
|
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters Lmr(B) expression in Bacillus subtilis and allows Lmr(B) to confer resistance to lincomycin.
Pssm-ID: 411077 [Multi-domain] Cd Length: 479 Bit Score: 120.90 E-value: 1.87e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 3 QTAAKdASTKFVVIGLLLGILMSAMDNTIVATAMGNIVADLG-----SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRK 77
Cdd:NF000060 4 ETTAK-ASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLMkelniTAATVQWLTTGYLLVLGILVPVSGLLLQWFTTR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 78 RFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGA 157
Cdd:NF000060 83 QLFTVSLIFSILGTFIAALAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 158 LITDSISWHWVFYINVPIGILSLFFILRYYKESLEHKKQKIDWAGAITLVVSIVGLMFALELGGK-TYDWNSVQIIGLFA 236
Cdd:NF000060 163 LVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGIVFGFSNAGEgSGGWSSPTVIVSLI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 237 VFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVI 316
Cdd:NF000060 243 VGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILGVIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGF 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 317 GSMIGGIFQTKVRFRNLMLISVVAFFIGMLLLSNMTpdTARTMLTVFMLISGFGVGFNFSLLPAASmndlepryrgsaNS 396
Cdd:NF000060 323 MSPVTGRLFDKYGPKWLVIPGFVIVTVVLWFFSNVT--TTSTAVLIIILHTCLMIGISMIMMPAQT------------NG 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 397 TNSFLRSFgMTLGVTIFGTIQtnvftnkltdSFSGMKGAGGAMQNIGNPQEIFQAGTRAHIPPHILDRiidAMSQSITYV 476
Cdd:NF000060 389 LNQLPREF-YPDGTAIMNTLQ----------QMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQ---ALTAGVQHA 454
|
490 500
....*....|....*....|...
gi 489248481 477 FTLALAPIVIAAVTILFMGKARV 499
Cdd:NF000060 455 FVFAMIVAIIGLIGAFFMKRVKV 477
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-416 |
4.57e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 117.66 E-value: 4.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 13 FVVIGLLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGS 91
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGlSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 92 ALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYI 171
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 172 nvpigilslffilryykeslehkkqkidwAGAITLVVSIVGLMFALelggktydwnsvqiiglfavfavffiaffiverk 251
Cdd:COG2271 170 -----------------------------LGLPGLLLALLRFWLLA---------------------------------- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 252 aeepiisfwmfknrlfataqILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKV--R 329
Cdd:COG2271 187 --------------------LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgrR 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 330 FRNLMLISVVAFFIGMLLLSNMTPDtarTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLG 409
Cdd:COG2271 247 RKLVLAIGLLLAALALLLLALLPSP---ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALG 323
|
....*..
gi 489248481 410 VTIFGTI 416
Cdd:COG2271 324 PLLVGYL 330
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-416 |
1.13e-28 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 116.91 E-value: 1.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMGNIVADLGSFDKFA-WVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGI 96
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIgLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 97 AQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIG 176
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 177 ILSLFFILRYYKESLEHKKQKidwagaitlvvsivglmfalelggktydwnsvqiiglfavfavffiaffiVERKAEEPI 256
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKR--------------------------------------------------AVSAARLRS 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 257 ISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLI 336
Cdd:cd17325 191 GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 337 SVVAFFIGMLLLSNMtpdTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFGTI 416
Cdd:cd17325 271 GLLLSAVALLLLPLA---TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
26-482 |
2.13e-24 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 105.97 E-value: 2.13e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 26 AMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVaVMAGMPI-YGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQL 103
Cdd:PRK14995 19 AIDATVLHVAAPTLSMTLGaSGNELLWIIDIYSL-VMAGMVLpMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 104 IIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMS-GMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFF 182
Cdd:PRK14995 98 IATRALLAIGAAMIVPATLAGIRATFTEEKQRNMAlGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 183 ILRYYKESLEHKKQKIDWAGAITLVVSIVGLMFALELGGKTyDWNSVQIIGLFAVFAVFFIAFFIVERKAEEPIISFWMF 262
Cdd:PRK14995 178 TARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKG-FLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLF 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 263 KNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNL----MLISV 338
Cdd:PRK14995 257 THRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVatggMALSA 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 339 VAFFigmlLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFGTIQT 418
Cdd:PRK14995 337 LSFY----GLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLLLS 412
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489248481 419 NVFTNKL---TDSFSGMkgAGGAMQNIGNPQEIFQAgtrahIPPHILDRIIDAMSQSITYVFTLALA 482
Cdd:PRK14995 413 RSYSASIrlpAGLPAQL--IEKASSSIGEAVQLANS-----LPPTLGQALLDAAKQAFIWSHSVVLS 472
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-416 |
2.60e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 101.88 E-value: 2.60e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 14 VVIGLLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSA 92
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGlSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 93 LCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYIN 172
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 173 VPIGILSLFFILRYYKESLEHKKQkidwagaitlvvsivglmfalelggktydwnsvqiiglfavfavffiaffiverKA 252
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAA------------------------------------------------------AA 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 253 EEPIISFW-MFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFR 331
Cdd:COG2223 192 KASLRDQLeALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGR 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 332 NLMLISVVAFFIGMLLLSNMTPDTarTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVT 411
Cdd:COG2223 272 RVLLIVFALMALGLLLLALALGSL--WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPL 349
|
....*
gi 489248481 412 IFGTI 416
Cdd:COG2223 350 LFGAL 354
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
18-435 |
5.75e-23 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 100.03 E-value: 5.75e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGI 96
Cdd:cd17476 3 ISGAQLLNQAGLGSVIVILPIIGDSFGtSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 97 AQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKM-SGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINvpi 175
Cdd:cd17476 83 SPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIvFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL--- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 176 GILSlffilryykeslehkkqkidwagAITLVVSIVglmfalelggktydwnsvqiiglfavfavffiaffiverkaeep 255
Cdd:cd17476 160 AILA-----------------------AIVAVAAIF-------------------------------------------- 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 256 iisfwmFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLML 335
Cdd:cd17476 173 ------WTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIMA 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 336 ISVVAFFIGMLLLSNMTPDTARTMLTVF-MLISGFGVGFNFsllPAASM---NDLEPRYRGSANSTNSFLRSFGMTLGVT 411
Cdd:cd17476 247 ISMVAFLVGPILFATMPVHQTYWAQAFPaMIVAPFGMDFSF---PAATIiasNAVPREYQGLAGSLVNTVVNYGISIGLG 323
|
410 420
....*....|....*....|....
gi 489248481 412 IFGTIQTNVFTNKlTDSFSGMKGA 435
Cdd:cd17476 324 IAGTVETSVNEDG-ADLLKGYRAA 346
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
15-416 |
3.98e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 98.01 E-value: 3.98e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 15 VIGLLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSAL 93
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGvSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 94 CGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGK-MSGMFGAVFgLSSVLGPLLGALITDSISWHWVFYIN 172
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRaIGLVFSGLT-LGLVLGRPLGGLLGQLLGWRAAFLAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 173 VPIGILSLFFILRYYKESLEHKKQKIDWAGAITLVvsivglmfalelggktydwnsvqiiglfavfavffiaffiverka 252
Cdd:cd17324 160 AVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLL--------------------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 253 eepiisfwmFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRN 332
Cdd:cd17324 195 ---------LRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 333 LMLISVVAFFIGMLLLSNMTPDTArtmLTVFMLISGFGVGFNFSLLPAAsMNDLEPRYRGSANSTNSFLRSFGMTLGVTI 412
Cdd:cd17324 266 LLIALLLLAAALLLLTLLGPSPLL---LLVGLVLWGLGFFAAHSALQTR-VLRLAPEARGLASSLYLAAYNLGGALGAAL 341
|
....
gi 489248481 413 FGTI 416
Cdd:cd17324 342 GGLV 345
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
16-438 |
2.10e-20 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 92.64 E-value: 2.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 16 IGLLLGILMSAMDNTIVATAMGNIVADLGSFDKF--AWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSAL 93
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELlvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 94 CGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDsISWHWVFYINV 173
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 174 pIGILSLFFILRYYKESLEHKKQKIDWAGAITlvvsivglmfalelggKTYDWNSVQIIGlfavfavffiaffiverkae 253
Cdd:cd17473 161 -LALPVLILVLLFLPEPARKSKSAASPGAATA----------------AALPWKRVLPIY-------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 254 epiisfwmfknrlfataqILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNL 333
Cdd:cd17473 204 ------------------FLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 334 MLISVVAFFIGMLLLSnmtpdTARTMLTVF--MLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVT 411
Cdd:cd17473 266 LAIGFALMALGFLLLA-----LASGLWVVLlgAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPL 340
|
410 420
....*....|....*....|....*..
gi 489248481 412 IFGTIQTNVFTNKLTDSFSGMKGAGGA 438
Cdd:cd17473 341 VLGPLVNLTGGLSGAFLILGVLALVLA 367
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-423 |
3.38e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.41 E-value: 3.38e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGI 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGlSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 97 AQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSI--SWHWVFYINVP 174
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 175 IGILSLFFILRYYKESLEHKKQKIDWAGAITLVVSIVGLmfalelggktydwnsvqiiglfavfavffiaffiverkaee 254
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRV----------------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 255 piisfwmFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTkvRFRNLM 334
Cdd:cd06174 200 -------LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD--RLIGRK 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 335 LISVVAFFIGMLLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFG 414
Cdd:cd06174 271 PLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG 350
|
....*....
gi 489248481 415 TIQTNVFTN 423
Cdd:cd06174 351 FLLAATFGL 359
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
23-403 |
1.42e-18 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 87.25 E-value: 1.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 23 LMSAMDNTIVATAMGNIVADLGSFDKFAWVTAS-YMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMD 101
Cdd:cd17323 9 FVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSlFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 102 QLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVpigilslf 181
Cdd:cd17323 89 MLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA-------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 182 filryykeslehkkqkidWAGAITLVVSIVGLmfalelggktydwnsvqiiglfavfavffiaffiverkaeePIIsfwm 261
Cdd:cd17323 161 ------------------IISGFCLILIFLFL-----------------------------------------PIV---- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 262 fknrlFATAQILAFLYGATFVILAVFIPIFVQaVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRN--------- 332
Cdd:cd17323 178 -----LLLGLYVGLVYAILYLFLTAFPYVFGE-VYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLkkknggkpe 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 333 ------LMLISVVAFFIGMLLLS-NMTPDTARTMLTVFMLISGFGVGFNFSllpaASMN---DLEPRYRGSANSTNSFLR 402
Cdd:cd17323 252 pearlpPAFIGAFLFPIGLFIFGwTIYPHIHWIVPIIGSAFFGFGLMLIFQ----SSLTylvDSYPKYAASALAANTLVR 327
|
.
gi 489248481 403 S 403
Cdd:cd17323 328 S 328
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
18-433 |
4.11e-18 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 86.14 E-value: 4.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMGNIVADLGSFDKFA-WVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGI 96
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAgLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 97 AQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSI-SWHWVFYINVPI 175
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 176 GILSLFFILRYYKESleHKKQKIDWAGAITLVVSIVGLMFALeLGGKTYDWNSVQIIglfavfavffiaffiverkaeep 255
Cdd:cd17328 164 GVLLAILLLLFVREP--PRGAAEGGVMAKSTATSFLADLKAL-AKNPSFILSTLGFT----------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 256 iisfwmfknrlfataqILAFLYGAtfviLAVFIPIFVQAVYGSTATSAG------FILTpmMIGSVIGSMIGGIFQTKVR 329
Cdd:cd17328 218 ----------------AVSFVTGA----LAFWAPTFFLRAFGVGDLSSAdvglifGAIT--CIAGVLGVLLGGILADRLR 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 330 FRN---LMLISVVAFFIGM--LLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRS- 403
Cdd:cd17328 276 RKTpraDPLVCAVGLLAAApfLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHl 355
|
410 420 430
....*....|....*....|....*....|
gi 489248481 404 FGMTLGVTIFGTIQtNVFTNKLTDSFSGMK 433
Cdd:cd17328 356 LGDAGSPYLIGLIS-DLLRQNKDSPLAEAA 384
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
18-421 |
1.05e-16 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 81.47 E-value: 1.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMGNIVADLGSFDK----FAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSAL 93
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGAsgyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 94 CGIAQTMDQLIIYRVIQGIGGGALmPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINV 173
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 174 PIGILSLFFILRYykeslehkkqkidwagaITLVVSIVGLMFALELGGKTYdwnsvqiiglfavfavffiaffiverkae 253
Cdd:cd17330 160 ALALLNLVLVLFF-----------------LPPLRRLLLVYFLIALAFAGL----------------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 254 EPIISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFvqavygstatsagfiltpmmigsvigsmigGIFQTKVRFRNL 333
Cdd:cd17330 194 ESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLI------------------------------PRLAKRLGERKL 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 334 MLISVVAFFIGMLLLSNMtpdTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIF 413
Cdd:cd17330 244 LRLGLLLAIIGLLLLPFA---SSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLA 320
|
....*...
gi 489248481 414 GTIQTNVF 421
Cdd:cd17330 321 GPLYSFLG 328
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
54-190 |
1.47e-16 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 76.53 E-value: 1.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 54 ASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEK 133
Cdd:TIGR00880 5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 489248481 134 RGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYYKES 190
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
15-439 |
2.10e-16 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 80.72 E-value: 2.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 15 VIGLLLGILMSAMDNTIVATAMGNIVADLGSFDKFAWVTASYMVAvMAGMPI----YGKLSDMYGRKRFFLFGLILFLIG 90
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAG-FLGRPIgallFGYLGDRIGRKKALILTLLLFGLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 91 SALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSIS----WH 166
Cdd:cd17316 80 TLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 167 WVFYINVPIGilslffilryykeslehkkqkidwagaitlvvsivglmfalelggktydwnsvqiiglfavfavffiaff 246
Cdd:cd17316 160 ILFLIGALPA---------------------------------------------------------------------- 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 247 iverkaeepIISFWMFKNRLFATaqILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQT 326
Cdd:cd17316 170 ---------LLALLLRRRTLLLI--LLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 327 KVRFRNLMLISVVAFFIGMLLLSNMTPDTARTMLTVFMLISGFGVGFNFSLlpAASMNDLEP-RYRGSANSTNSFLRSFG 405
Cdd:cd17316 239 RIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGAL--YAYLAELFPtEVRATGVGLSYNLGRLG 316
|
410 420 430
....*....|....*....|....*....|....
gi 489248481 406 MTLGVTIFGTIQTNVFTNKLTDSFSGMKGAGGAM 439
Cdd:cd17316 317 GGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
33-488 |
2.37e-16 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 82.02 E-value: 2.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 33 ATAMGNIVADLGSFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGI 112
Cdd:pfam06609 64 ASALPNILQDIGQSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 113 GGGalmPIAFTIIFDLFPPEKRGKMSGMF--GAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYY--- 187
Cdd:pfam06609 144 AAG---PAGASPLFIGELMSNKTKFLGLLivSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIWYhpp 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 188 --------KESLEHKKQKIDWAGAITLVVSIVGLMFALELGGKTYD-WNSVQIIGLFAVFAVFFIAFFIVE--RKAEEPI 256
Cdd:pfam06609 221 sfaqlhgkKARKRDELAKLDWIGIFLVIAGTSLFLLGVSWGGKPNNpWNSAKIIGLISSGAGSLVIFALYEvfGKPEQPI 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 257 ISFWMFKN-RLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATS---AGFILTPMMIGSVIGSMI-GGIFQTKVRFR 331
Cdd:pfam06609 301 IPPALFKDtRGFVCILIISSIMGAMHLCLTIIYPQQVINIFGSSLKNweeTAWMSATASFGTGAGVMIlGNLFHLIRHIR 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 332 NLMLISVVAF--FIGMLLLSNMTPDTARTMLTVFmliSGFGVGF--NFSLLPAASMNDLEPryRGSANSTNSFLRSFGMT 407
Cdd:pfam06609 381 WQILVGALWLtaFLGAMSSINRDNKNAAIALSFF---SGFVVAWaqDITMLLVQFITTDED--LGVAFAVVAAARPFAGS 455
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 408 LGVTIFGTIQTNVFTNKLTDSFSgmkgagGAMQNIGNPQEIF----QAGTRAHIP-----PHILDRIIDAMSQSIT---- 474
Cdd:pfam06609 456 IFTAAFISLYSNQYPKEIASHLS------SALRGTDFPQASFpsllEAAKSGRIDavkalPGMTNEIAAVVSQAMAdsyt 529
|
490 500
....*....|....*....|
gi 489248481 475 ------YVFTLALAPIVIAA 488
Cdd:pfam06609 530 asyanvYYFAMALGVIPIIA 549
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
14-192 |
3.62e-16 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 80.48 E-value: 3.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 14 VVIGLLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSA 92
Cdd:TIGR00895 18 AIILSFLIMLMDGYDLAAMGFAAPAISAEWGlDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 93 LCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYIN 172
Cdd:TIGR00895 98 LCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVG 177
|
170 180
....*....|....*....|
gi 489248481 173 VPIGILSLFFILRYYKESLE 192
Cdd:TIGR00895 178 GIAPLLLLLLLMRFLPESID 197
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
52-414 |
1.43e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 78.02 E-value: 1.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 52 VTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPP 131
Cdd:cd17489 36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 132 EKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYYKESLEHKKQKIDWAGAITLVVSIV 211
Cdd:cd17489 116 SRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 212 GLMFALelggktydwnsvqiiglfavfavffiaffiverkaeepiisfwmfknrlfataqiLAFLYGATFVILAVFIPIF 291
Cdd:cd17489 196 VLPPAL-------------------------------------------------------ILFLASIAYGAISTFLPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 292 VQAvygSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGMLLLSNMTPDtarTMLTVFMLISGFGV 371
Cdd:cd17489 221 AAE---RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSP---WMLLLAAVLYGLGF 294
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 489248481 372 GFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFG 414
Cdd:cd17489 295 GLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLG 337
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
13-416 |
3.13e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 77.23 E-value: 3.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 13 FVVIGLLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGS 91
Cdd:cd17319 3 RIIPLLFLAYVINYLDRVNISVAAPTIMKDLGlSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 92 ALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYI 171
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 172 NVPIGILSLFFILRYYKeslehkkqkidwagaitlvvsivglmfalelggktydwnsvqiiglfavfavffiaffiverk 251
Cdd:cd17319 163 EGLLGLLLAVLWWFYLR--------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 252 aeepiiSFWMFknrlfataQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFR 331
Cdd:cd17319 180 ------QVWGL--------ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 332 NLMLISVVAFFIGMLLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVT 411
Cdd:cd17319 246 ARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPL 325
|
....*
gi 489248481 412 IFGTI 416
Cdd:cd17319 326 LIGYL 330
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
18-416 |
5.93e-15 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 76.50 E-value: 5.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMGNIVADL-GSFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGI 96
Cdd:cd06173 4 LWLAQLLSALGDWIFTVALPWLVLQLtGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 97 AQTMD-----QLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYI 171
Cdd:cd06173 84 LALLGslslwLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 172 NVPIGILSLFFILRYYKESLEHKKQKIDWAGAitlvvsivglmfALELGGktydwnsvqiiglfavfavffiaffiverk 251
Cdd:cd06173 164 NALSFLLSALLLLFIRRPPPAAPGESSSLLLR------------DLREGL------------------------------ 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 252 aeepiisFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFR 331
Cdd:cd06173 202 -------RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRG 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 332 NLMLISVVAFFIGMLLLSNMTPDtarTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVT 411
Cdd:cd06173 275 RLLLIGALLLGLALLVLGLSPSL---WLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGAL 351
|
....*
gi 489248481 412 IFGTI 416
Cdd:cd06173 352 LAGLL 356
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
56-195 |
1.53e-14 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 75.44 E-value: 1.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 56 YMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRG 135
Cdd:PRK10473 47 YLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRA 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 136 KMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYYKESLEHKK 195
Cdd:PRK10473 127 KVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKETRPARA 186
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
20-394 |
2.20e-14 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 74.65 E-value: 2.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 20 LGILMSAMDNTIVATAMGNIVADLGSFDKFAWVTASYMVAVMA-GMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQ 98
Cdd:cd17371 6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAiGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 99 TMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSG---MFGAV-FGLSSVLGPLLGALITDSISWHWVFYINVp 174
Cdd:cd17371 86 NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGyvqSGWAVgWLLATLLAALLFPLLPPEIAWRVLFLLGA- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 175 IGILSLFFILRYYKESLEhkkqkidWAGAitlvvsivglmfalelggktydwnsvqiiglfavfavffiaffIVERKAEE 254
Cdd:cd17371 165 LPALLVLFIRRFVKEPPQ-------WQAA-------------------------------------------RAARRHFA 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 255 PIISFWMFKNRLFATAQILAFLYGA----TFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRF 330
Cdd:cd17371 195 DRPSLRELFSPPLLRTTLLASLLATgalgGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGR 274
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489248481 331 RNLMLISVVAFFIGMLLLSNMTPDTarTMLTVFMLISGFGVGFNFSLLpAASMNDLEP-RYRGSA 394
Cdd:cd17371 275 RNNFALFALGSAISILLYFFLPLSP--TLILILGFPLGFFASGPFSGM-GAYLTELFPtAVRATA 336
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
67-414 |
2.79e-14 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 74.17 E-value: 2.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 67 YGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIggGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFG 146
Cdd:cd17472 52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALIGASIG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 147 LSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYYKESLEHKKQKIDWAGAITLVVSIVGLMfalelggktydw 226
Cdd:cd17472 130 IAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLL------------ 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 227 nsvqiiglfavfavffiaffiverkaeepiisfwmfknRLFATAQILAFLYGATFVIlavfIPIFVQAVYGSTAtSAGFI 306
Cdd:cd17472 198 --------------------------------------RLDFSIFILHFVLMAFFYI----LPLLLTQLGGGKG-QLWKV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 307 LTPMMIGSVIGSMIGGIFQTKVR-FRNLMLISVVAFFIGMLLLSNmtpdTARTMLTVFMLISGFGVGFNF--SLLPAASM 383
Cdd:cd17472 235 YLPAILIGFILMVPFVIYAEKKGkMKQVFVSSILLIAVGFLLLLF----AATSLWLLIIGLIIFFIGFNLleALLPSLVS 310
|
330 340 350
....*....|....*....|....*....|.
gi 489248481 384 NDLEPRYRGSANSTNSFLRSFGMTLGVTIFG 414
Cdd:cd17472 311 KIAPKEYRGTAMGIYNTSQFLGSFLGGALGG 341
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
55-396 |
7.98e-14 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 73.19 E-value: 7.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 55 SYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKR 134
Cdd:TIGR00710 48 LYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEEL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 135 GKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYYKESLEHKKQkidwagaitLVVSIVGLM 214
Cdd:TIGR00710 128 SRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEAR---------IQISTYFET 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 215 FALELGGKTYdWNSVQIIGlfavfavffiaffiverkaeepiisfwmfknrlFATAQILAFLYGATFVIlavfipifvQA 294
Cdd:TIGR00710 199 FLLLLKSKMF-WGYALIYG---------------------------------ASFGGFFAFFSGAPFVY---------ID 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 295 VYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGMLLL--SNMTPDTARTMLTVFMLISGFGVG 372
Cdd:TIGR00710 236 IMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLeiTAILGLGSWAMIIGPMMFVGIGNS 315
|
330 340
....*....|....*....|....
gi 489248481 373 FNFSLLPAASMNDLePRYRGSANS 396
Cdd:TIGR00710 316 MISSIAMAYALEDF-PHVAGTASA 338
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
22-171 |
3.05e-13 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 71.08 E-value: 3.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 22 ILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTM 100
Cdd:cd17365 8 IVLDGFDLAVMGFVAPALAQDWGlSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSV 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489248481 101 DQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYI 171
Cdd:cd17365 88 LQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
56-187 |
3.35e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.07 E-value: 3.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 56 YMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRG 135
Cdd:cd17325 244 QGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRG 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 489248481 136 KMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYY 187
Cdd:cd17325 324 TAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
10-416 |
9.78e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.80 E-value: 9.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 10 STKFVVIGLLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFL 88
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGlSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 89 IGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSgMFGAVFGLSSVLGPLLGALITD---SISW 165
Cdd:COG0738 85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLN-LLHAFFSLGALLGPLLGGLLILlglSLSW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 166 HWVFYInvpigilslffilryykeslehkkqkidwAGAITLVVSIVGLMFALELGGKTydwnsvqiiglfavfavffiaf 245
Cdd:COG0738 164 HLPYLI-----------------------------LAVLLLLLALLFLRSKLPEIEEE---------------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 246 fiVERKAEEPIISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQ 325
Cdd:COG0738 193 --EEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 326 TKVRFRNLMLISVVAFFIGMLLLSNMtpdTARTMLTVFMLISGFGVGFNFSLLPAASMNDLePRYRGSANSTNSFLRSFG 405
Cdd:COG0738 271 KRFGPVRLLRLSALLAAVGLLLALLA---PGPWLALIGLALVGLGLSLMFPTIFSLALDGL-GKRTAAAVSAVLIMGIVG 346
|
410
....*....|.
gi 489248481 406 MTLGVTIFGTI 416
Cdd:COG0738 347 GAIGPPLIGFL 357
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
27-418 |
2.02e-11 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 65.82 E-value: 2.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 27 MDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLII 105
Cdd:TIGR00893 8 LDRANLSFAAPMLQEDLGlSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 106 YRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILR 185
Cdd:TIGR00893 88 LRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIWGVLWLK 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 186 YYKESLEHKKQKIDWAGAItlvvsIVGLMFALELGGKTYDWNSVQIIGLfavfavffiaffiverkaeepiisfwmFKNR 265
Cdd:TIGR00893 168 FIPDPPQKAKWLTEEEKYI-----VVGGLLAEQQGKGPSTPKKYQIKEL---------------------------LKDR 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 266 LFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGM 345
Cdd:TIGR00893 216 RVWGLALGQFLVNIGLGFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIA 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489248481 346 LLLSNMTPDTARTMLTVFMLISGFGVGF---NFSLLPAASMNDLEPRY-RGSANSTNSFLRSFGMTLGVTIFGTIQT 418
Cdd:TIGR00893 296 GLVLSLLMFATNYVNIPYAALALVALGFfglGAGAIGWALISDNAPGNiAGLTGGLINSLGNLGGIVGPIVIGAIAA 372
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
62-348 |
4.34e-11 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 65.02 E-value: 4.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 62 AGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMF 141
Cdd:cd17322 52 VSQPPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFASAIP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 142 GAVFGLSSVLGPLLGALITDSISWHW---VFYINVPIGILSLFFILRYY----------KESLEHKK------------- 195
Cdd:cd17322 132 SLPYIITTWIGGNIAQAALPNSNWRWgygMWAIILPLSSLPLVLCLLYMqrkarkdgeiKELKNQETeeqtgglsqnlvk 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 196 --QKIDWAGAITLVVSIVGLMFALEL-GGKTYDWNSVQIIGLFAVFAVFFIAFFIVE-RKAEEPIISFWMFKNRLFATAQ 271
Cdd:cd17322 212 lfWKLDIFGVILLTAGLGLILVPLTLaGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEaKFAKYPFLPFRLLKDRTILAAC 291
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489248481 272 ILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKV-RFRNLMLISVVAFFIGMLLL 348
Cdd:cd17322 292 LIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTrRYKVLVIIGVPLYIVGMGLL 369
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
35-191 |
5.21e-11 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 64.17 E-value: 5.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 35 AMGNIVADLGSFDKFAWVTASYMVAVMA-GMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIG 113
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAiGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489248481 114 GGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYYKESL 191
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETL 170
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
18-380 |
5.79e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 64.12 E-value: 5.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMG----NIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSA 92
Cdd:COG2807 19 LLLAIVLVALNLRPAITSVGpllpEIRADLGlSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 93 LCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFpPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYIn 172
Cdd:COG2807 99 LRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 173 vpigilslffilryykeslehkkqkidWAgAITLVVSIVGLMFALELGGktydwnsvqiiglfavfavffiaffiVERKA 252
Cdd:COG2807 177 ---------------------------WA-LLALLALLLWLPLLRRRPA--------------------------AAAAA 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 253 EEPIISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQAvYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVR-FR 331
Cdd:COG2807 203 PAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGdRR 281
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489248481 332 NLMLISVVAFFIGMLLLSnMTPDTArtmLTVFMLISGFGVGFNFSLLPA 380
Cdd:COG2807 282 PLLLLLGLLGLAGLLGLL-LAPGSL---PWLWAVLLGLGQGGLFPLALT 326
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
48-187 |
6.06e-10 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 60.67 E-value: 6.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 48 KFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFD 127
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 128 LFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDsisWHWVFYInvpIGILSLFFILRYY 187
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLA---ISLPGLLFLLLLW 159
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
49-206 |
6.25e-10 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 61.11 E-value: 6.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 49 FAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGgALMPIAFTIIFDL 128
Cdd:cd17388 40 YGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITG-ATGAVAAAYIADV 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489248481 129 FPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDsISWHWVFYINVPIGILSLFFILRYYKESLE-HKKQKIDWAGAITL 206
Cdd:cd17388 119 TPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFLVAAGLNGLNFLLGLFVLPESLPpERRRAFRWRRANPF 196
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
65-200 |
3.05e-09 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 58.82 E-value: 3.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 65 PIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMpIAFTIIFDLFPPEKRGKMSGMFGAV 144
Cdd:cd17389 82 PITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVS-LSTAIVADVTSPKKRSKGMALIGVA 160
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489248481 145 FGLSSVLGPLLGALI-TDSISWHWVFYINVPI-----GILSLFFILRYYKESLEHKKQKIDW 200
Cdd:cd17389 161 FSLGFIIGPMIGAYFaSFTRSLGEVFFSMPALfalvlALADLLFIFFFLPETLPSNLRRLGL 222
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
103-348 |
7.12e-09 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 57.98 E-value: 7.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 103 LIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDsiswhwvFYINVPIGILS--- 179
Cdd:pfam03137 91 FFLGQLLLGIGGTPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLR-------IYVDIGKVSITltp 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 180 ----------LFFILryykeslehkkqkidwAGAITLVVSIVGLMFALELGGKTydWNSVQIIGLFAVFAVFFIAFFIVE 249
Cdd:pfam03137 164 kdprwvgawwLGFLI----------------AGLLLLLTAIPFFFFPKSLPGAA--KRRAKKKKEPHSQDIADLKKTKSL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 250 RKAEEPIISFW-----MFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMI-GSVIGSMIGGI 323
Cdd:pfam03137 226 KKLGPSLKDFPkalkrLLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVAIpGAALGILLGGL 305
|
250 260
....*....|....*....|....*..
gi 489248481 324 F--QTKVRFRNLMLISVVAFFIGMLLL 348
Cdd:pfam03137 306 IikKFKLSAKGLAKFNVITSLVSLLLS 332
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
51-184 |
1.33e-08 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 56.90 E-value: 1.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 51 WVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIA---QTMDQLIIYRVIQGIGGGALMPIAFTIIFD 127
Cdd:pfam00083 50 LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISE 129
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489248481 128 LFPPEKRGKMSGMfgavFGLSSVLGPLLGALIT-------DSISWHWVFYINVPIGILSLFFIL 184
Cdd:pfam00083 130 IAPKKLRGALGSL----YQLAITFGILLAYIFGlglnktsNSDGWRIPLGLQLVPALLLIIGLL 189
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
52-160 |
1.62e-08 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 56.47 E-value: 1.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 52 VTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMpIAFTIIFDLFPP 131
Cdd:cd17390 36 IGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQS-LCKAYLSDLVSE 114
|
90 100
....*....|....*....|....*....
gi 489248481 132 EKRGKMSGMFGAVFGLSSVLGPLLGALIT 160
Cdd:cd17390 115 QERSRVLGRFNAASSLGFILGPVVGGHLA 143
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
18-197 |
2.06e-08 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 56.45 E-value: 2.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSA---MDNTIVATAMGNIVADLGsfdkfawVTASYMVAVMAG--MP------IYGKLSDMYGRKRFFLFGLIL 86
Cdd:PRK11652 10 LFMLVLLVAvgqMAQTIYVPAIADMARDLN-------VREGAVQAVMAAylLTyglsqlFYGPLSDRVGRRPVILVGMSI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 87 FLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWH 166
Cdd:PRK11652 83 FILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWR 162
|
170 180 190
....*....|....*....|....*....|.
gi 489248481 167 WVFYINVPIGILSLFFILRYYKESLEHKKQK 197
Cdd:PRK11652 163 ACYLFLLLLGAGVTFSMARWMPETRPADARR 193
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
12-171 |
3.02e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 55.73 E-value: 3.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 12 KFVVIGLLLGILMSAMDNTIVATAMGNIVADLGSFDK----FAWVTASYM-VAVMAGMPIYGKLSDMYGRKRFFLFGLIL 86
Cdd:cd17391 200 PSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASnlafISGLVFSATgVSSLLSAPRLGKLGDRIGHHRILLGALLA 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 87 FLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWH 166
Cdd:cd17391 280 SALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYR 359
|
....*
gi 489248481 167 WVFYI 171
Cdd:cd17391 360 AVFVV 364
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
51-202 |
3.59e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 55.65 E-value: 3.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 51 WVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFP 130
Cdd:cd17359 40 LVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 131 PEKRGKMSGM------FG--AVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILsLFFILRYYKES---LEHKKQKID 199
Cdd:cd17359 120 AEIRGRLVSLnqlmivFGqlLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAIL-FLLGMLFIPESprwLVSKGKPIL 198
|
...
gi 489248481 200 WAG 202
Cdd:cd17359 199 IIG 201
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
56-186 |
4.02e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 4.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 56 YMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRG 135
Cdd:cd17489 236 YAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRG 315
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 489248481 136 KMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRY 186
Cdd:cd17489 316 AANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
61-416 |
7.83e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 54.25 E-value: 7.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 61 MAGMPIYGKLSDMYGRKRFflFGLILFLIGSALCGIAQTMDQLIIY--RVIQGIGGGALMPIAFTIIFDLFpPEKRGKMS 138
Cdd:cd17333 45 LIGSLLAGFLMKRLGRRRT--LILGLLLISLALALIFATPSIYLFVvlMFLAGLGAGILDTGANTFVGALF-EESSATRL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 139 GMFGAVFGLSSVLGPLL-GALITDSISWHWVFYINVPIGILSLFFILRYYKESLEHKKQKIDWAGAItlvvsivglmfal 217
Cdd:cd17333 122 NVLHGFFGLGALIGPLIaTSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAF------------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 218 elggktydwnsvqiiglfavfavffiaffiverkaeePIISFWMFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYG 297
Cdd:cd17333 189 -------------------------------------SASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 298 STATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGMLLLSNMTPdtartmlTVFMLISGFGVGFNFSL 377
Cdd:cd17333 232 VSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPT-------LVVGLVATALLGLFMAA 304
|
330 340 350
....*....|....*....|....*....|....*....
gi 489248481 378 LPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFGTI 416
Cdd:cd17333 305 LFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIM 343
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
52-183 |
7.91e-08 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 54.64 E-value: 7.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 52 VTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPP 131
Cdd:TIGR00898 132 TQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPK 211
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 489248481 132 EKRGKMSGMFGAVFGLSSVLGPLLGALITDsisWHWV-FYINVP--IGILSLFFI 183
Cdd:TIGR00898 212 KQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WRWLqLAVSLPtfLFFLLSWFV 263
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
68-416 |
1.03e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 54.15 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 68 GKLSDMYGRKRFFLFGLILFLIGSALC-GIAQTMDQLIIYRVIQGIGGGalMPIAFTIIF-DLFPPEKRGKMSGMFGAVF 145
Cdd:cd17490 52 GILSDRIGKRKLFIIIGLLFTVLASLImILFPSPWGLLIARFLSGIAAA--TWVSFTVLYaSYFPPDEAAKAMGLINLVN 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 146 GLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYYKESLEHKKQKIDWAGAITlvvsivglmfalelggktyd 225
Cdd:cd17490 130 NLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKELLS-------------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 226 wnsvqiiglfavfavffiaffiverkaeepiisfwMFKNRLFATAQILAFL-YGATFVILAVFIPIFVQAVyGSTATSAG 304
Cdd:cd17490 190 -----------------------------------VLKDKKLLFFSLLAILqQMITFSTTFGFTPLIAKQL-GASSFQLG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 305 FILTPMMIGSVIGSMIGG-IFQTKVRFRNLMLISvvafFIGMLLLSNMTPDTAR-TMLTVFMLISGFGVGFNFSLLPAAS 382
Cdd:cd17490 234 LLSIIYLLPNALASLLSGtLFYKKLGERNTIIIG----FLLLGAYCFLIPFAPNlTLLYLLQALNGFGTGILFPLLMSLS 309
|
330 340 350
....*....|....*....|....*....|....
gi 489248481 383 MNDLEPRYRGSANSTNSFLRSFGMTLGVTIFGTI 416
Cdd:cd17490 310 IEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGII 343
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
20-190 |
1.23e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 53.73 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 20 LGILMSAMDNTIVATAMGNIVADLG-SFDKFA--WVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGI 96
Cdd:cd17315 4 LGGLLFGYDLGVINGALLYIAKDLGfGLSTSLqgLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 97 AQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMF--GAVFG--LSSVLGplLGALITDSISWHWVFYIN 172
Cdd:cd17315 84 APNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNqlMITFGilLAYLLG--LALSLSPPGWWRLMFALA 161
|
170
....*....|....*...
gi 489248481 173 VPIGILsLFFILRYYKES 190
Cdd:cd17315 162 AVPALL-QLLLMFFLPES 178
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
50-396 |
1.88e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.94 E-value: 1.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 50 AWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFdLF 129
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLAS-QA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 130 PPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYYKESLEHKKQKidwagaitlvvs 209
Cdd:cd17478 113 AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKA------------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 210 ivglmfalelggktydwnsvqiiglfavfavffiaffIVERKAEEPIISFWMFKNRLFataqILAFLYGATFVILAVFIP 289
Cdd:cd17478 181 -------------------------------------AAKSSARSTLKGVWRALLLLL----IIVFLRSWVLSSLTTFLP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 290 IFVQAVYGSTATsAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGMLLLSNMTPdtarTMLTVFMLISGF 369
Cdd:cd17478 220 FYLVQRGYSLVF-AGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPG----IWSYILLVLAGF 294
|
330 340
....*....|....*....|....*..
gi 489248481 370 GVGFNFSLLPAAsMNDLEPRYRGSANS 396
Cdd:cd17478 295 LLFASFPVTVVL-AQELLPGNVGLASG 320
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
3-190 |
3.56e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 52.27 E-value: 3.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 3 QTAAKDASTKFVVIGLLLGI-LMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFF 80
Cdd:PRK11551 4 RTSSASSSRLALTIGLCFLVaLLEGLDLQSAGVAAPRMAQEFGlDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRIL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 81 LFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGK-MSGMF-GAVFGlsSVLGPLLGAL 158
Cdd:PRK11551 84 IVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTaVSLMYcGVPFG--GALASVIGVL 161
|
170 180 190
....*....|....*....|....*....|..
gi 489248481 159 ITDSISWHWVFYINVPIGILSLFFILRYYKES 190
Cdd:PRK11551 162 AAGDAAWRHIFYVGGVGPLLLVPLLMRWLPES 193
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
272-416 |
3.77e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.04 E-value: 3.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 272 ILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGMLLLSNM 351
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489248481 352 TPDTartMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFGTI 416
Cdd:pfam07690 83 SSLW---LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL 144
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-184 |
4.04e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.17 E-value: 4.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 50 AWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLf 129
Cdd:cd17324 237 IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL- 315
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 489248481 130 PPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFIL 184
Cdd:cd17324 316 APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
15-188 |
6.04e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 51.40 E-value: 6.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 15 VIGLLLGILMSAMDNTIVATAMGNIVADLGSFDKFA-WVTAS----YMVAVMAGmpiyGKLSDMYGRKRFFLFGLILFLI 89
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQgLVLSSffwgYALTQVLG----GYLADRFGGKKVLLLAVALWSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 90 GSALCGIA--QTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHW 167
Cdd:cd17380 77 ATLLTPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPS 156
|
170 180
....*....|....*....|.
gi 489248481 168 VFYINVPIGILSLFFILRYYK 188
Cdd:cd17380 157 VFYFFGLLGLLWALVWLIYLP 177
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
14-409 |
6.45e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.41 E-value: 6.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 14 VVIGLLLGILMSAMDNTIVATAMGNIVADLgsfDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSAL 93
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVST---ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 94 CGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALitdsiswhwvfyinV 173
Cdd:cd17477 78 LALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL--------------V 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 174 PIGILSLFFIlryykeslehkkqkidwaGAITLVVSIVGLMFALELGGKTYdwnsvqiiglfavfavffiaffiverkaE 253
Cdd:cd17477 144 GTAGALPFLI------------------AAVLLLLALVPLLLTRRAAPEIE----------------------------E 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 254 EPIISFWMFKnRLFATAQILAFLYGATFVILAVFIPIFVQAVyGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNL 333
Cdd:cd17477 178 AESISLRRLL-RIAPLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRV 255
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489248481 334 MLISVVAFFIGMLLLSnMTPDTARTMLTVFMLISGFGVGFnFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLG 409
Cdd:cd17477 256 LLGCALLGALAALLLP-LVPGLPLALLVLLFLWGGAAGPL-YTLALALAGDRLPGDELVAANAALLLLYGLGSVIG 329
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
262-416 |
7.63e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.13 E-value: 7.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 262 FKNRLFATAQILAFLYGATFVILAVFIPIFVQAvYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAF 341
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489248481 342 FIGMLLLSnMTPDTarTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFGTI 416
Cdd:COG2814 86 ALGSLLCA-LAPSL--WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
65-197 |
7.82e-07 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 51.46 E-value: 7.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 65 PIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGaLMPIAFTIIFDLFPPEKRGKMSGMF--G 142
Cdd:PRK09874 72 PFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNANALIATQVPRNKSGWALGTLstG 150
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 489248481 143 AVFGlsSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYYKESLEHKKQK 197
Cdd:PRK09874 151 GVSG--ALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPVSKK 203
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
29-198 |
1.10e-06 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 50.71 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 29 NTIVATAMGNIVADLGSfdKFAWVTASYMVAVMAGMP---IYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLII 105
Cdd:PRK15402 29 NDMIQPGMLAVVEDFNA--GAEWVPTSMTAYLAGGMFlqwLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 106 YRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILR 185
Cdd:PRK15402 107 LRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWR 186
|
170
....*....|...
gi 489248481 186 YYKESLEHKKQKI 198
Cdd:PRK15402 187 AMPETAGRVGEKL 199
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-184 |
1.89e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 50.12 E-value: 1.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 12 KFVVIGLLLGILMSAMDNTIVATAMGNIVADLGSFDKFAWVTASYMVAVMAGMPIYGKLSDMY-GRKRFFLFGLILFLIG 90
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 91 SALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDS-ISWHWVF 169
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAF 363
|
170
....*....|....*
gi 489248481 170 YINVPIGILSLFFIL 184
Cdd:cd06174 364 LVLAVLLLLAAILLL 378
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
46-184 |
2.03e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 46 FDKFAWVTASYMVA----VMAGMPIyGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIA 121
Cdd:cd17370 230 GLSAALIPLLYALFnlvyALAAYPA-GRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIE 308
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489248481 122 FTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFIL 184
Cdd:cd17370 309 RAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
261-499 |
2.18e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.90 E-value: 2.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 261 MFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVA 340
Cdd:COG2211 224 LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 341 FFIGMLLLSNMTPDTArTMLTVFMLISGFGVGFNFSLLPAASMNDLEP-------RYRGSANSTNSFLRSFGMTLGVTIF 413
Cdd:COG2211 304 AALGLLLLFFLGPGNL-WLLLVLAALAGIGLGAILVLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKLGQALAGALA 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 414 GTIqtnvftnkltdsfsgmkgaggaMQNIGnpqeiFQAGtrAHIPPHILDRIidamsqsityVFTLALAPIVIAAVTILF 493
Cdd:COG2211 383 GLL----------------------LALFG-----YVAG--AAQSPSALTGI----------RLLFFLLPAVLLLLAALL 423
|
....*.
gi 489248481 494 MGKARV 499
Cdd:COG2211 424 LLFYPL 429
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
3-184 |
3.92e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.11 E-value: 3.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 3 QTAAKDASTKFVVIGLLLGILMSAMDNTIVATAMGNIVADLGSFD--KFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFF 80
Cdd:cd17473 187 GAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSaaLIGLALAIASLAGAIGALLFGRLKRRLGKRRLL 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 81 LFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALIT 160
Cdd:cd17473 267 AIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLV 346
|
170 180
....*....|....*....|....
gi 489248481 161 DSISWHWVFYINVPIGILSLFFIL 184
Cdd:cd17473 347 NLTGGLSGAFLILGVLALVLAIVL 370
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
66-197 |
6.31e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 48.35 E-value: 6.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 66 IYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVF 145
Cdd:PRK11043 60 LWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLV 139
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 489248481 146 GLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYYKESLEHKKQK 197
Cdd:PRK11043 140 ALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKARKQSQ 191
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
50-182 |
6.35e-06 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 48.30 E-value: 6.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 50 AWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGAlMPIAFTIIFDLF 129
Cdd:cd17372 37 ALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGG-GPQLASWYLEFL 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 489248481 130 PPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYI-NVPIGILSLFF 182
Cdd:cd17372 116 PAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFsSVPSSLLLVFY 169
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
291-408 |
6.59e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 48.33 E-value: 6.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 291 FVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGMlLLSNMTPDTarTMLTVFMLISGFG 370
Cdd:cd17359 26 FLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA-LGSAFSPNF--TIFIIARIIGGLA 102
|
90 100 110
....*....|....*....|....*....|....*...
gi 489248481 371 VGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTL 408
Cdd:cd17359 103 VGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLL 140
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
261-416 |
7.48e-06 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 48.37 E-value: 7.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 261 MFKNRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAgFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVA 340
Cdd:cd17332 217 LLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELV-LLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 341 FFIGMLLLSNMTPDTArTMLTVFMLISGFGVGFnFSLLPAASMNDLEP--------RYRGSANSTNSFLRSFGMTLGVTI 412
Cdd:cd17332 296 AILGLLLLFFLPPGNL-VLILVLAVLAGIGYGG-ANLLPWAMLADVIDygelktgkRREGIFYSVMTFFRKLGLALAGAL 373
|
....
gi 489248481 413 FGTI 416
Cdd:cd17332 374 VGLI 377
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
103-187 |
7.95e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 48.00 E-value: 7.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 103 LIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYInvpIGILSLFF 182
Cdd:cd17318 114 LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYI---FGGLGLLW 190
|
....*
gi 489248481 183 ILRYY 187
Cdd:cd17318 191 CLLWF 195
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
65-183 |
8.94e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.03 E-value: 8.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 65 PIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGaLMPIAFTIIFDLFPPEKRGKMSGMFGAV 144
Cdd:cd17391 54 PIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQTPKEKSGWALGTLSTG 132
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 489248481 145 FGLSSVLGPLLGALITDSISWHWVFYIN----VPIGILSLFFI 183
Cdd:cd17391 133 VVAGTLIGPLLGGFLADLFGIRNVFFITggllFLAFLLTLFFV 175
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
58-185 |
9.90e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 9.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 58 VAVMAGMPIYGKLSDM-YGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGK 136
Cdd:cd17474 245 VLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGT 324
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 489248481 137 MSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILR 185
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
57-409 |
1.47e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.22 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 57 MVAVMAGMPIY-GKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRG 135
Cdd:cd17329 44 SAVAGIVASLIgGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 136 KMSGMFGAVFGLSSVLGPLLGALITDSiswhwvfyinvpiGILSLFfilryykeslehkkqkidWAGAITLVVSIVGLMF 215
Cdd:cd17329 124 RAFSLLYWAINLGVAIGPLLGGLLLLY-------------SFRLLF------------------LAAAVLFLLAALVLLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 216 ALELGGKTydwnsvqiiglfavfavffiaffiVERKAEEPIISFWM--FKNRLFATAQILAFLYGATFVILAVFIPIFVQ 293
Cdd:cd17329 173 LLPETRPK------------------------RRAAEKTEILRGYKivLRDRAFLLFLLASFLISLIYFQLESTLPVYVV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 294 AVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGMLLLSNMtpdTARTMLTVFMLISGFGVGF 373
Cdd:cd17329 229 EILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFA---NTLAVLILAMIVLTLGEML 305
|
330 340 350
....*....|....*....|....*....|....*.
gi 489248481 374 NFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLG 409
Cdd:cd17329 306 VFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIG 341
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
1-184 |
1.73e-05 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 47.13 E-value: 1.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 1 MEQTAAKDASTKFVVIGLLLGILMSAMDNTIVATAMGNIVADLGSFDKFAWVTAS-YMVAVMAGMPIYGKLSDMYGRKRF 79
Cdd:PRK15403 4 MPRFFARHAATLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSlYLAGGMALQWLLGPLSDRIGRRPV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 80 FLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALI 159
Cdd:PRK15403 84 LITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAAL 163
|
170 180
....*....|....*....|....*
gi 489248481 160 TDSISWHWVFYINVPIGILSLFFIL 184
Cdd:PRK15403 164 MHFVHWKVLFAIIAVMGLIAFVGLL 188
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
49-185 |
1.89e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 49 FAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDL 128
Cdd:cd06173 246 YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLR 325
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 489248481 129 FPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILR 185
Cdd:cd06173 326 VPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
65-416 |
2.87e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.43 E-value: 2.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 65 PIYGKLSDM----YGRKRF-FLFGLILFLIGSALCGIAQTMDQliIYRVIQGIGGGALMPIAFTIIF--------DLFP- 130
Cdd:COG2211 64 PLIGALSDRtrtrWGRRRPwILIGAIPLALSFVLLFTAPDLSP--TGKLIYALVTYLLLGLAYTLVNipysalgaELTPd 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 131 PEKRGKMSGMFGAVFGLSSVLGPLLGALITDSIS------WHWVFYINVPIGILSLFFILRYYKESLEHKKQKIDWAGAI 204
Cdd:COG2211 142 YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESL 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 205 TLVvsivglmfalelggktydwnsvqiiglfavfavffiaffiverkaeepiisfwmFKNRLFATAQILAFLYGATFVIL 284
Cdd:COG2211 222 KAL------------------------------------------------------LKNRPFLLLLLAYLLFFLALALV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 285 AVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGMLLLSNMTPDTArTMLTVFM 364
Cdd:COG2211 248 AALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNL-WLLLVLA 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 489248481 365 LISGFGVGFNFSLLPAASMNDLEP-------RYRGSANSTNSFLRSFGMTLGVTIFGTI 416
Cdd:COG2211 327 ALAGIGLGAILVLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
68-186 |
3.09e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 46.27 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 68 GKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQ--LIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVF 145
Cdd:TIGR00894 97 GYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIalVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGF 176
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 489248481 146 glssVLGPLLGALITDSISWHW-----VFYIN--VPIGILSLFFILRY 186
Cdd:TIGR00894 177 ----QLGTFIFLPISGWLCESWggwpmIFYVFgiVGCAWSLLWFVFPA 220
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
13-184 |
4.01e-05 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 46.23 E-value: 4.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 13 FVVIGLLLGILMSAMDNTIVATAmgnivadlgsfdkfAWVTASYMVAVMAGMpIYGKLSDMYGRKRFFLFGLILFLIGSA 92
Cdd:PRK03893 36 FVLITLVLTEVQGEFGLTTVQAA--------------SLISAAFISRWFGGL-LLGAMGDRYGRRLAMVISIVLFSVGTL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 93 LCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYin 172
Cdd:PRK03893 101 ACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFF-- 178
|
170
....*....|..
gi 489248481 173 vpIGILSLFFIL 184
Cdd:PRK03893 179 --IGILPIIFAL 188
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
50-188 |
4.19e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.03 E-value: 4.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 50 AWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQ-TMDQLIIYRVIQGIGGGALMPIAFTIIFDL 128
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDI 323
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489248481 129 FPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSI-SWHWVFYINVPIGILSLFFILRYYK 188
Cdd:COG2223 324 FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
14-184 |
4.50e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.63 E-value: 4.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 14 VVIGLLLGILMSAMdnTIVATAMGNIVADLGSFdkfawVTASYMVAVMAGMPIyGKLSDMYGRKRFFLFGLILFLIGSAL 93
Cdd:cd17477 198 FVAGFLEGAFYSLL--PLYGLRLGLSVAQAALL-----LAAFVLGGLLLQWPL-GWLADRFDRRRVLLGCALLGALAALL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 94 CGIAQTMD-QLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYIn 172
Cdd:cd17477 270 LPLVPGLPlALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLF- 348
|
170
....*....|..
gi 489248481 173 vpIGILSLFFIL 184
Cdd:cd17477 349 --LAAVALLFLL 358
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
50-193 |
4.70e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 45.63 E-value: 4.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 50 AWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLF 129
Cdd:COG2807 253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRA 332
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489248481 130 P-PEKRGKMSGMFGAVFGLSSVLGPLL-GALITDSISWHWVFYINVPIGILSLFFILRYYKESLEH 193
Cdd:COG2807 333 RtPAEAAALSGMAQSVGYLLAALGPLLvGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPYVED 398
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
102-187 |
6.40e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.29 E-value: 6.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 102 QLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLF 181
Cdd:cd17490 286 LLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAI 365
|
....*.
gi 489248481 182 FILRYY 187
Cdd:cd17490 366 LSLAYY 371
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
45-184 |
6.51e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 45.29 E-value: 6.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 45 SFDKFAWVTASYMVAVMA-----GMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQL-IIYRVIQGIGGGALM 118
Cdd:cd17353 242 EFAGLDAGIAALAVSILSifnggGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLfVLGVALIGFCYGGGF 321
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489248481 119 PIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFIL 184
Cdd:cd17353 322 ALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALAL 387
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
3-187 |
7.10e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.91 E-value: 7.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 3 QTAAKDASTKFVVIGLLLGILMSAMDNTIVATAMGNIVADlgSFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLF 82
Cdd:cd17329 194 KIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGL--GESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMI 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 83 GLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDS 162
Cdd:cd17329 272 GILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDL 351
|
170 180
....*....|....*....|....*
gi 489248481 163 ISWHWVFYINVPIGILSLFFILRYY 187
Cdd:cd17329 352 LGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
47-407 |
8.36e-05 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 44.87 E-value: 8.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 47 DKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIF 126
Cdd:cd17358 41 AQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 127 DLFPPEKRGKmsgmFGAVFGLSSVLGPLLGALITDSISWHWVFYI-NVP--IGILSLFFIlryyKESLEH--KKQKIDWA 201
Cdd:cd17358 121 EIAPKNVRGA----LGSLNQLLVNIGILLGYVLGSFLPWRTLALIgAIPpvVFLILLFFI----PESPRWlaKKGREEEA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 202 gaitlvvsIVGLMFaleLGGKTYDWNSvqiiglfavfAVFFIAFFIVERKAEEPIISFWMFKNRlfatAQILAFLYGATF 281
Cdd:cd17358 193 --------EKSLQF---LRGKDADISK----------EAAEIQEELAELEKEAKESSFSDLFQR----KYLKPLVIGLGL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 282 VILAVFIPIFVQAVYGST-ATSAGFILTP----MMIGSV--IGSMIGGIFQTKVRFRNLMLISVVAFFIGMLLLS----- 349
Cdd:cd17358 248 MLFQQLSGINAVIFYASSiFDEAGSGLDPntatIIIGVVqvVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGlyfyl 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489248481 350 -NMTPDTARTMLTVFMLISGFGVGFNFSL--LPAASMNDLEPRY-RGSANS----TNSFLrSFGMT 407
Cdd:cd17358 328 qEHGALLSSVSWLPLVGLVIYIISFSIGLgpLPWVIMSEIFPAKiKGLAGSlvtlVNWLF-AFIVT 392
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
57-414 |
1.24e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.18 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 57 MVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLII-YRVIQGIGGGALMPIAFTIIFDLFPPEKRG 135
Cdd:cd17355 48 LLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLlWGLLGGGGAGTLAAVAFATVAAWWFERRRG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 136 KMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYInvpigilslffilryykeslehkkqkidWAGAITLVVSIVGLMF 215
Cdd:cd17355 128 LALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV----------------------------LALLALLVLVPVLLLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 216 ALELGGktydwnsvqiIGLFAVFAVFFIAFFIVERKAeepiisfwmFKNRLFATAQILAFLYGATFVILAVFIPIFVQAV 295
Cdd:cd17355 180 RRRPAD----------LALRAYDDASPASPGSTLKEA---------LRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 296 YGSTATSAGfILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGMLLLSNMTPDTarTMLTVFMLISGFGVGFNF 375
Cdd:cd17355 241 GISPAAAAV-ALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPP--LALLLFAALFGLGWGATV 317
|
330 340 350
....*....|....*....|....*....|....*....
gi 489248481 376 SLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFG 414
Cdd:cd17355 318 PLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGG 356
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
260-416 |
1.25e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.09 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 260 WMFKNRLFATAQILAFLYGATFVILAVFIPiFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVV 339
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAP-PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489248481 340 AFFIGMLLLSNMTpdtARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFGTI 416
Cdd:COG2271 84 LWGLATLLFGFAT---SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL 157
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
33-416 |
1.27e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 44.29 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 33 ATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQG 111
Cdd:TIGR00881 15 ALAMPYLVEEIGlSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 112 IGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGP-LLGALITDSISWHWVFYINVPIGILSLFFILRYYKES 190
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 191 LEHKKQkidwagaitlvvSIVGLMFALELGGKTydwnsvqiiglfavfavffiAFFIVERKAEEpIISFWMFKNRLfatA 270
Cdd:TIGR00881 175 PQSCGL------------PPAEEMPNEEPDGDA--------------------EKKEEELTKKQ-IFLQYVLLNKV---L 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 271 QILAFLYGATFVILAVFI---PIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTK--VRFRNLMLISVVAFFIGM 345
Cdd:TIGR00881 219 WYISLGYVFVYVVRTGILdwsPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKlfNGRRGPLAVFFMALIIVS 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489248481 346 LLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFGTI 416
Cdd:TIGR00881 299 LLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYL 369
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
52-372 |
1.45e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 44.17 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 52 VTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSAL---CGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDL 128
Cdd:cd17357 54 IVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLmflSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEI 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 129 FPPEKRGKMSGM----------FGAVFGLSSVLGpllgalitDSISWHWVFYINVPIGILSLfFILRYYKES----LEHK 194
Cdd:cd17357 134 SPSELRGALGSLtqigvtlgilLGQVFGLPSVLG--------TETLWPYLLFFPGIPALLQL-AALPFFPESpkflLISK 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 195 KQKIDwagaitlvvSIVGLMFaleLGGKTYDWNSVQIiglfavfavffIAFFIVERKAEEPIISFW-MFKNRLF--ATAQ 271
Cdd:cd17357 205 GDEEE---------AEKSLKF---LRGIEDDVDQELE-----------EIKKESEQMGDQKQVSLMqLLRDPSLrlPLLL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 272 ILAFLYGATF----VILAVFIPIFVQAvyGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLIS-------VVA 340
Cdd:cd17357 262 VLVVSASQQFsginAIFFYSTFIFENA--GFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISlsvcavaLLL 339
|
330 340 350
....*....|....*....|....*....|..
gi 489248481 341 FFIGMLLLSNMTPDTARTMLTVFMLISGFGVG 372
Cdd:cd17357 340 MSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIG 371
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
50-184 |
1.57e-04 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 44.25 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 50 AWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCG---IAQTMDQLIIYRVIQGIGGGALMPIAFTIIF 126
Cdd:TIGR00879 74 GLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGlaaFALSVEMLIVGRVLLGIGVGIASALVPMYLS 153
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489248481 127 DLFPPEKRGKMSGMfgavFGLSSVLGPLLGALITD-------SISWHWVFYINVP---IGILSLFFIL 184
Cdd:TIGR00879 154 EIAPKALRGALTSL----YQLAITFGILVAYGFGSgkvslnnTLGWRIPLGLQLIpagLLFLGLFFLP 217
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
18-160 |
1.98e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.74 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 18 LLLGILMSAMDNTIVATAMGNIVADL--GSFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCG 95
Cdd:COG2211 233 LLLAYLLFFLALALVAALLLYYFKYVlgLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF 312
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 96 IAQTMD--QLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKR---GKMSGMFGAVFGLSSVLGPLLGALIT 160
Cdd:COG2211 313 FLGPGNlwLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgRRREGLYFGIFTFAIKLGQALAGALA 382
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
103-349 |
2.16e-04 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 43.77 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 103 LIIYRVIQGIGGGALMPIAFTIIFDLFPPEKrgkmSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSlff 182
Cdd:cd17336 91 LFVGQFLLGIGSSPLYTLGITYIDDNVSKKN----SPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVPLGITP--- 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 183 ilryykeslehkkQKIDWAGAITLVVSIVGLMFALelggktydwnsvqiiglfavfavffiaffiverkaeePIISFWMF 262
Cdd:cd17336 164 -------------DDPRWIGAWWLGFLILGILLLI-------------------------------------VSIPLFFF 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 263 KnRLFATAQILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMI-GSVIGSMIGGIFQTKVRFRNLMLISVVAF 341
Cdd:cd17336 194 P-PIFILLLLAIVFESFAISGFSTFLPKYLETQFRLSASLASLLTGLILVpGAALGILLGGLIIKKFKLTARGLAKFVLI 272
|
....*...
gi 489248481 342 FIGMLLLS 349
Cdd:cd17336 273 LSLLSVIL 280
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
45-185 |
2.51e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.33 E-value: 2.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 45 SFDKFAWVTASYMVAVMAGMPIYGKLSD-MYGRKRFFLFGLILFLIGSALCGIAQTMDQL--IIYRVIQGIGGGALMPIA 121
Cdd:cd17319 213 SLKQVGLLAAIPFLAGAIGMILGGRLSDrLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVvaVILLSLAGFGIGAASPVF 292
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489248481 122 FTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLL-GALITDSISWHWVFYINVPIGILSLFFILR 185
Cdd:cd17319 293 WSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLiGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
50-180 |
2.92e-04 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 43.26 E-value: 2.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 50 AWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALmPIAFTIIFDLF 129
Cdd:cd17441 37 ALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGV-PQSVTLYAEFL 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 489248481 130 PPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYIN-VPIGILSL 180
Cdd:cd17441 116 PMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSaLPLLIFAV 167
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
57-185 |
2.92e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.95 E-value: 2.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 57 MVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGK 136
Cdd:cd17330 221 IAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGK 300
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 489248481 137 MSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILR 185
Cdd:cd17330 301 AQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
20-137 |
5.08e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 42.26 E-value: 5.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 20 LGILMSAMDNTIVATAMGNIVADLGSFDKFAW----VTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCG 95
Cdd:cd17360 4 IGGFLFGYDTGVISGALLYIKDDLGEVVLSTGwqelIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMA 83
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 489248481 96 IAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKM 137
Cdd:cd17360 84 AAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRL 125
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
52-184 |
5.89e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 42.24 E-value: 5.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 52 VTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSAL-CGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFP 130
Cdd:cd17356 50 IVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIqVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAP 129
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489248481 131 PEKRGKMSGMfgavFGLSSVLGPLLGALIT-------DSISWHWVFYIN-VPIGILSLFFIL 184
Cdd:cd17356 130 KHIRGTLVSL----YQLAITIGILVAYCINygthkldGSAQWRIPLGLQiVWGLLLLIGMFF 187
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
58-145 |
8.07e-04 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 41.83 E-value: 8.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 58 VAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGK- 136
Cdd:cd17438 45 LGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEh 124
|
90
....*....|....
gi 489248481 137 -----MSGMFGAVF 145
Cdd:cd17438 125 lswlcMFWMIGGLY 138
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-153 |
8.38e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.63 E-value: 8.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 15 VIGLLLGILMSAMDNTIVATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSAL 93
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGlSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489248481 94 CGIAQTMDQLIIYR---VIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGP 153
Cdd:pfam07690 282 LLLLSLTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
58-136 |
8.78e-04 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 41.71 E-value: 8.78e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489248481 58 VAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGK 136
Cdd:cd17363 45 LGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGE 123
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
272-409 |
8.94e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.44 E-value: 8.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 272 ILAFLYGATFVILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGMLLL--S 349
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLgfA 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 350 NMTPDTArtmltVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLG 409
Cdd:cd17329 86 HSPWLFA-----IALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIG 140
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
65-204 |
1.04e-03 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 41.64 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 65 PIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMdqliiYRVIQGIGGgaLMPIAFTIIF----DLFPPEKRGKMSGM 140
Cdd:cd17387 54 PLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWW-----YFAMISVSG--IFSVTFSVIFayvaDITTEEERSTAYGL 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489248481 141 FGAVFGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFILRYYKESLEHKKQKIDWAGAI 204
Cdd:cd17387 127 VSATFAASLVTSPALGAYLSESYGDNLVVLVATIVALLDICFILLAVPESLPEKMRPASWGAPI 190
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
52-178 |
1.22e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 41.18 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 52 VTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPP 131
Cdd:cd17362 44 VVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPS 123
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 489248481 132 EKRGKMSGMFGAVFGLSSVLGPLLGALITDSIS-WHWVFYINVPIGIL 178
Cdd:cd17362 124 HIRGLLVSLKELFIVLGILLGYVSGYAFADVVGgWRYMYGLAAPPALL 171
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
20-198 |
1.23e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 41.45 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 20 LGILMSAMDNTIVATAMGNIVADLGSFD-KFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQ 98
Cdd:PRK12307 25 LGYVFDGFDFMLIFYIMYLIKADLGLTDmEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLAS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 99 TMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYINVpIGIL 178
Cdd:PRK12307 105 GVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGL-LPVL 183
|
170 180
....*....|....*....|
gi 489248481 179 SLFFILRYYKESLEHKKQKI 198
Cdd:PRK12307 184 LVIYIRARAPESKEWEEAKL 203
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
33-425 |
1.56e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 40.72 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 33 ATAMGNIVADLG-SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQG 111
Cdd:cd17312 23 SVAKPPIVEEIGlSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 112 IGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSISWHWVFYInvpigilslffilryykesl 191
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLV-------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 192 ehkkqkidwAGAITLVVSivglmfalelggktydwnsvqiiglfavfavffiaffiverkaeepIISFWMFKNR---LFA 268
Cdd:cd17312 163 ---------PGIVGLVVA----------------------------------------------IILFFFLRDSppyVWV 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 269 TAQILAFLYGATFVILaVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKV--RFRNLMLISVVAFFIGML 346
Cdd:cd17312 188 LSLAYAFVYIVRYACL-DWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 347 LLSNMTPDtARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRY-RGSANSTNSFLRSFGMTLGVTIFGTIQTNVFTNKL 425
Cdd:cd17312 267 ALFWFFPH-NKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEaAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTV 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
263-416 |
1.60e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.56 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 263 KNRLFATAQILAFLYGATFVILAVFIPIfVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFF 342
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489248481 343 IGMLLLSnMTPDTArtMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFLRSFGMTLGVTIFGTI 416
Cdd:COG0477 91 LASLLCG-LAPSPE--LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
51-145 |
2.87e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 40.35 E-value: 2.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 51 WVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFP 130
Cdd:TIGR01299 206 MLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLA 285
|
90 100
....*....|....*....|.
gi 489248481 131 PEKRGK------MSGMFGAVF 145
Cdd:TIGR01299 286 QEKRGEhlswlcMFWMIGGIY 306
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
258-406 |
3.51e-03 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 40.06 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 258 SFWMFKNRLFATAQILAFLY------GATFVILAVFI-PIFVQAVYGSTATsaGFILTPMMIGSVIGSMIGGIFQTKVRF 330
Cdd:PRK10077 7 SSYIFSITLVATLGGLLFGYdtavisGTVESLNTVFVaPQNLSESAANSLL--GFCVASALIGCIIGGALGGYCSNRFGR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 331 RNLMLISVVAFFIGML-------LLSNMTPDTARTMLT--VFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNSFL 401
Cdd:PRK10077 85 RDSLKIAAVLFFISALgsawpefGFTSIGPDNTGYVPEfvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFA 164
|
....*
gi 489248481 402 RSFGM 406
Cdd:PRK10077 165 IIFGQ 169
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
274-416 |
3.95e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.50 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 274 AFLYGATFVILAVFIPIFVQAVYGSTATSAGFILT-PMMIGSVIGSMIGGI---FQTKV-RFRNLMLISVVAFFIGMLLL 348
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLvARLWDAITDPLIGALsdrTRTRWgRRRPWILIGAIPLALSFVLL 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489248481 349 SnMTPDTARTMLTVFMLIS--GFGVGFNFSLLPAASM-NDL--EPRYRGSANStnsfLRSFGMTLGVTIFGTI 416
Cdd:COG2211 99 F-TAPDLSPTGKLIYALVTylLLGLAYTLVNIPYSALgAELtpDYEERTRLSS----WRFAFAGLGGLLASVL 166
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
304-409 |
5.20e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.18 E-value: 5.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 304 GFILTPMMIGSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGMLLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASM 383
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYIS 128
|
90 100
....*....|....*....|....*.
gi 489248481 384 NDLEPRYRGSANSTNSFLRSFGMTLG 409
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLA 154
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
45-184 |
8.27e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 8.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 45 SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMD--QLIIYRVIQGIGGGALMPIAF 122
Cdd:cd17316 211 SPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSptLLLLLLFILSFFVGGVWGALY 290
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489248481 123 TIIFDLFPPEKRGKMSGMFGAV-FGLSSVLGPLLGALITDSISWHWVFYINVPIGILSLFFIL 184
Cdd:cd17316 291 AYLAELFPTEVRATGVGLSYNLgRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
61-414 |
8.50e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.35 E-value: 8.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 61 MAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLIIYRvIQGIGGGAlMPIAFTIIFDLFPPEKRGKMSGM 140
Cdd:cd17331 49 LVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSR-LPSVFMHA-MQAAQMVVTDLTDPGERAAALGR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 141 FGAVFGLSSVLGPLLGALITDSISWHWVFYInvpigilslffilryykeslehkkqkidwAGAITLvVSIVGLMFALELG 220
Cdd:cd17331 127 LGLSYGIGMVVGSFLGGLLTKKFGEQAAALV-----------------------------AAVGSL-LSIVLVILLIPSN 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 221 GKTYDWNSVQIIGLfavfavffiaffiverKAEEPIISFWMFKNRLFATAQILAFLYGATF---VILAVFIPIFVQAvYG 297
Cdd:cd17331 177 TKSKREKEAKESAS----------------PPSVFNLKEILRLLRLPGVAFLLLVKLLSGLpigMFQSMFSLVAMDF-FG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 298 STATSAGFILTPMMIGSVIGSMIGGIFQTKvRF--RNLMLISVVAFFIGMLLLSNMTPDTARTMLTVFMLISGFGVGfnf 375
Cdd:cd17331 240 LTPEENGYLMSYAGVLGMVVQGLLVGPLTK-RFgeRSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLY--- 315
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 489248481 376 SLLPAASMNDLEPRYRGSA----NSTNSFLRSFGMTLGVTIFG 414
Cdd:cd17331 316 TVITSLLTKAVPPEDTGTAlglsHALFSLVRTVSPTIGGALLQ 358
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
68-414 |
8.95e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.29 E-value: 8.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 68 GKLSDMYG-RKRFFLFGLILFLIGSALCGIAQTMDQLIIYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFG 146
Cdd:cd17370 55 GYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDT 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 147 LSSVLGPLL--GALITDSISWHWVFYINVPIGILSLFFILRYYKESLEHKKQKidwagaitlvvsivglmfalelggkty 224
Cdd:cd17370 135 LGAVLGPLLaaLLLYLLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLR--------------------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 225 dwnsvqiiglfavfavffiaFFIVERKAEEPIISFWMFknrLFATAQILAFLYGATFVILAvfipifVQAVYGSTATSAG 304
Cdd:cd17370 188 --------------------KKSKKTSLKKLPKAFWLY---LLAVALFALGNFSFAFLILR------AQELGLSAALIPL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489248481 305 FILTPMMIgSVIGSMIGGIFQTKVRFRNLMLISVVAFFIGMLLLSNMTPdtaRTMLTVFMLISGFGVGFNFSLLPAASMN 384
Cdd:cd17370 239 LYALFNLV-YALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSS---LWLLLLGFILWGLYMGAQESIERAAVAD 314
|
330 340 350
....*....|....*....|....*....|
gi 489248481 385 DLEPRYRGSANSTNSFLRSFGMTLGVTIFG 414
Cdd:cd17370 315 LVPAELRGTAYGLFNTVVGIGWLLASLIAG 344
|
|
| |
