|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
25-547 |
0e+00 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 701.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 25 TGTWAPFSIQAFRIIWICNLFANLGTWAQSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLW 104
Cdd:pfam05977 1 TSPLAPLRQGVFRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 105 GLSFEMTGAMFATLLAFLGYLDPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGG 184
Cdd:pfam05977 81 GQLLLALVSTLLTLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 185 LLLSAVGPAWVFLFNSFCYMALIWAIWQWRRDVPKRSLPPEGILEGVIAALRFTQYSTVTRLVMMRSFAFGLSASAVWAL 264
Cdd:pfam05977 161 VLLAAFGPAFTFALNALSYFAVIAALWRWKRAAPASPLPRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 265 LPLLAHRNPDGDAAIYGYMLGALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGGGC 344
Cdd:pfam05977 241 LPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 345 WIGALATYNSAVQILVPDWIKARALALYQTALYGGLALGSFLWGHLAETMTVHGALLAAGCLLLASVILLYNSRLPEMDA 424
Cdd:pfam05977 321 WITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAGLRFRLPEGEA 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 425 A-SISRAPasMPGQP-SFVFNTRRGMVLVSIEYRIPAERTRDFVRAAQPLRRLRLRNGAERWSLFRDVSNPEVWQELFLV 502
Cdd:pfam05977 401 AdLIPSNH--WPEPLvALAVKPRRGPVLVLIEYSIDKEDIPAFLKAMAELRRERRRDGAYGWGLTRDLANPEVWVETFMV 478
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 489249317 503 DNWIQHLRMLDRMTLADKIVIDNVTALHAGDGPPQIRHCVSYEAS 547
Cdd:pfam05977 479 ESWAEHLRHHQRVTAADADVQDKVTAFHSGKEPPQVRHSLSIERP 523
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
36-397 |
1.25e-72 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 237.13 E-value: 1.25e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 36 FRIIWICNLFANLGTWAQSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFEMTGAMF 115
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 116 ATLLAFLGYLDPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWV 195
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 196 FLFNSFCYMALIWAIWQWRRDVPKRSLPPEGIL-EGVIAALRFTQYSTVTRLVMMRSFAFGLSASAVWALLPLLAHRNPD 274
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLlRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 275 GDAAIYGYMLGALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGALATYNS 354
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 489249317 355 AVQILVPDWIKARALALYQTALYGGLALGSFLWGHLAETMTVH 397
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
27-382 |
2.16e-38 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 144.35 E-value: 2.16e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 27 TWAPFSIQAFRIIWICNLFANLGTWAQSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGL 106
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 107 SFeMTGAMFATLLAflgyLDPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLL 186
Cdd:COG2814 83 LL-FALGSLLCALA----PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 187 LSAVGPAWVFLFNSFCYMALIWAIWQWRRDVPKRSLPPEGilegviAALRFTQYSTVTRLVMMRSFAFGLSASAVWALLP 266
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLR------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 267 LLAHRNPDGDAAIYGYMLGALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWI 346
Cdd:COG2814 232 LYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFG 311
|
330 340 350
....*....|....*....|....*....|....*.
gi 489249317 347 GALATYNSAVQILVPDWIKARALALYQTALYGGLAL 382
Cdd:COG2814 312 LLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
61-393 |
3.04e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 119.22 E-value: 3.04e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 61 VTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLsfemtGAMFATLLAFLGYLDPVLLIISILWISLG 140
Cdd:cd17325 23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGL-----LLLAVSTLLFAFATSYWQLLLARFLQGLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 141 GSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLFNSFCYMALIWAIWQWRRDVPKR 220
Cdd:cd17325 98 SAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 221 SLPPEGILEGVIAALRFTQYSTVTRLVMMRSFAFGLSASAVWALLPLLAHRNPDGDAAIYGYMLGALGLGAILGSTQVSR 300
Cdd:cd17325 178 PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 301 LRQRIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGALATYNSAVQILVPDWIKARALALYQTALYGGL 380
Cdd:cd17325 258 LSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGM 337
|
330
....*....|...
gi 489249317 381 ALGSFLWGHLAET 393
Cdd:cd17325 338 VLGPLLGGFLYDA 350
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
39-384 |
2.06e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 101.73 E-value: 2.06e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 39 IWICNLFANLGTWAQSVAAAWVVTDA-HASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGlsfeMTGAMFAT 117
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIG----LLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 118 LLAFLGYLDPVLLIISILwISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFL 197
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVL-QGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 198 FNSFCYMALIWAIWQWRRDVPKRSLPPEGILEGVIAALRFTQYSTVTRLVMMRSFAFGLSASAVWALLPLLAHRnPDGDA 277
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 278 AIYGYMLGALGLGAILGSTQVSRLRQRIGSSR---LISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGALATYNS 354
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314
|
330 340 350
....*....|....*....|....*....|
gi 489249317 355 AVQILVPDWIKARALALYQTALYGGLALGS 384
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
65-392 |
6.97e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 88.78 E-value: 6.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 65 HASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFEMTGAMFATLLAFLgyldPVLLIISILWiSLGGSVT 144
Cdd:cd17474 30 GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF----ALLLAGRALQ-GIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 145 IPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLlSAVGPAWVFLFNSFCYMALIWAIWQWrrdVPKRSLPP 224
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAILFL---LPEPKEKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 225 EGILEGVIAALRFTQYSTVTRLVMMRSFAFGLSASAVWALLPLLAHRNPDGDAAIYGYMLGALGLGAILGSTQVSR-LRQ 303
Cdd:cd17474 181 KSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKK 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 304 RIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGALATYNSAVQILVPDWIKARALALYQTALYGGLALG 383
Cdd:cd17474 261 RFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
|
....*....
gi 489249317 384 SFLWGHLAE 392
Cdd:cd17474 341 PLLFGLLLE 349
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
65-388 |
1.17e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 81.83 E-value: 1.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 65 HASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGlsfeMTGAMFATLLAFLGYLDPVLLIISILwISLGGSVT 144
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVL----LLLFILGNLLAALAPSFALLLLARAL-AGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 145 IPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLFNSFCYMALIWAIWQWRRDVPKRSLPP 224
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 225 EGILEGVIAALRftqySTVTRLVMMRSFAFGLSASAVWALLPLLAHRNPDGDAAIYGYMLGALGLGAILGSTQVSRLRQR 304
Cdd:cd17324 185 LGLLSSLLLLLR----NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 305 IGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGALATYNSAVQILVPDwIKARALALYQTALYGGLALGS 384
Cdd:cd17324 261 GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-ARGLASSLYLAAYNLGGALGA 339
|
....
gi 489249317 385 FLWG 388
Cdd:cd17324 340 ALGG 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
39-395 |
5.13e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.16 E-value: 5.13e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 39 IWICNLFANLGTWAQSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFemtGAMFATL 118
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLL---FALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 119 LAFLGYLdPVLLIISILWiSLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLF 198
Cdd:cd06174 78 FAFAPSF-WLLLLGRFLL-GLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 199 NSFCYMALIWAI--WQWRRDVPKRSLPPEGILEG--VIAALRFTQYSTVTRLVMMRSFAFGLSASAVWALLPLLAHRNPD 274
Cdd:cd06174 156 LIAAALALLAAIllLLVVPDPPESARAKNEEASSksVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 275 GDAAIYGYMLGALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALILL-TLGLVDNLWVLFPVLILGGGCWIGALATYN 353
Cdd:cd06174 236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLaLLLLAPSLLLLLLLLLLLGFGLGGLLPLSF 315
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 489249317 354 SAVQILVPDWIKARALALYQTALYGGLALGSFLWGHLAETMT 395
Cdd:cd06174 316 ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
37-386 |
8.41e-16 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 79.19 E-value: 8.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 37 RIIWICNLFANLGTWA-QSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFemTGAMF 115
Cdd:cd17329 2 WVLLIGSFLNRLGFFMvWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLL--RALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 116 AtLLAFLGylDPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAvGPAWV 195
Cdd:cd17329 80 A-LLGFAH--SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 196 FLFNSFCY-MALIWAIWQWRRDVPKRslpPEGILEGVIAALRFTQYSTVTRLVMMRSFAFGLSASAVWALLPLLAHRNPD 274
Cdd:cd17329 156 FLAAAVLFlLAALVLLFLLPETRPKR---RAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 275 GDAAIYGYMLGALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILgggCWIGALaTYNS 354
Cdd:cd17329 233 LGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIV---LTLGEM-LVFP 308
|
330 340 350
....*....|....*....|....*....|..
gi 489249317 355 AVQILVPDWIKARALALYQTALYGGLALGSFL 386
Cdd:cd17329 309 AVQTLVAALAPPDKRGSYMGFYALAWGLGRAI 340
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
35-414 |
2.04e-14 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 75.40 E-value: 2.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 35 AFRIIWICNLFANLGTWAQSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSfemTGAM 114
Cdd:PRK10489 18 AFRAVFIARFISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLARG---TCGL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 115 FATLLAFLGYLD-PVLLIISIL--WISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVG 191
Cdd:PRK10489 95 GFIGLALNAFLPePSLLAIYLLglWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 192 PAWVFLFNSFCYMALIWAIWQWRRdVPKRSLPPEGILEGVIAALRFTQYSTVTRLVMMRSFAFGLsASAVWALLPLLAHR 271
Cdd:PRK10489 175 VAWNYGLAAAGTFITLLPLLRLPA-LPPPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGLLTM-ASAVRVLYPALADE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 272 NPDGDAAIYGYMLGALGLGAILG---STQVSRLRqRIGSSRLISLAGftLALILLTLGLVDNLWVLFPVLILGGgcWIGA 348
Cdd:PRK10489 253 VWQMGAAQIGLLYAAVPLGAALGaltSGWLAHSA-RPGLLMLLSTLG--SFLAVGLFGLMPMWILAVLCLALFG--YLSA 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489249317 349 LATY--NSAVQILVPDWIKARALALYQTALYGGLALGSFLWGHLAETMTVHGALLAAGCLLLASVILL 414
Cdd:PRK10489 328 ISSLlqYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLL 395
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
59-392 |
3.64e-14 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 74.12 E-value: 3.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 59 WVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNH-DRRKIMLWglsfemtgAMFATLLAFLGYLD----PVLLIIS 133
Cdd:cd17471 22 FLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGgDRKPLILL--------ALLAGALGYLLFAFlrnyWVLLLVG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 134 ILWISLGGSvTIPAWQAAVNEQVPARMVSDAVLLNSV---NYNVARAAGPALGGLLLSAVGPAWVFLFNSFCYMALIWAI 210
Cdd:cd17471 94 VVLLSLGAA-AFPQLFALAREYADRSSGRDATLFNSVlraAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 211 WQWRRDVPKRSLPPEgilegvIAALRFTQYSTVTRLVMMRSFAFGLSASAVWAL-LPLLAHRNPDGDAAIYGYMLG---A 286
Cdd:cd17471 173 LFLLPSVKPPAQKAT------PASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIaMPLYVTNELGGSESWVGLLFGlaaA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 287 LGLGAILGStqvSRLRQRIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILgGGCWIGALATYN-SAVQILVPDWIk 365
Cdd:cd17471 247 LEIPIMLLA---GLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLL-NAIFIGITAGLGiSYFQDLMPGQP- 321
|
330 340
....*....|....*....|....*..
gi 489249317 366 ARALALYQTALYGGLALGSFLWGHLAE 392
Cdd:cd17471 322 GLATTLYSNASRIGSLLGGLLAGVIAQ 348
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
38-393 |
1.22e-13 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 72.60 E-value: 1.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 38 IIWICNLFANLGTWAQSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLsfeMTGAMFAT 117
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL---LLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 118 LLAFLGYLdPVLLIISILWiSLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFL 197
Cdd:COG2271 91 LFGFATSF-WQLLLLRFLL-GLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 198 FNSFcyMALIWAIWQwrrdvpkrslppegilegviaalrftqystvTRLVMMRSFAFGLSASAVWALLPLLAHRNPDGDA 277
Cdd:COG2271 169 ILGL--PGLLLALLR-------------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 278 AIYGYMLGALGLGAILGSTQVSRLRQRIGSSR--LISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGALATYNSA 355
Cdd:COG2271 216 AQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWAL 295
|
330 340 350
....*....|....*....|....*....|....*...
gi 489249317 356 VQILVPDWIKARALALYQTALYGGLALGSFLWGHLAET 393
Cdd:COG2271 296 AAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
54-316 |
4.93e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 66.76 E-value: 4.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 54 SVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFeMTGAMFATLLAFlgylDPVLLIIS 133
Cdd:COG0477 34 NVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL-FGLASLLCGLAP----SPELLIAA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 134 ILWISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLFNSFCYMALIWAIWQW 213
Cdd:COG0477 109 RALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 214 RRDVPKRSLPPEGILEGVIAALRFTQYSTVTRLVMMRSFAFGLSASAVWALLPLLAHRNPDGDAAIYGYMLGALGLGAIL 293
Cdd:COG0477 189 PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLL 268
|
250 260
....*....|....*....|...
gi 489249317 294 GSTQVSRLRQRIGSSRLISLAGF 316
Cdd:COG0477 269 LLLLALLLALLLLLLLLLLLLLL 291
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
35-397 |
1.73e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.03 E-value: 1.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 35 AFRIIWICNLFANLGTWAQSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFemtgaM 114
Cdd:COG0738 9 ALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL-----M 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 115 FATLLAFLGYLDPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNyNVARAAGPALGGLLLSA-VGPA 193
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFF-SLGALLGPLLGGLLILLgLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 194 WVFLFNSFCYMALIWAIWQWRRDVPKRSLPPEGILEGVIAALRFTQYSTVTRLVMMrSFAFGLSASAVWALLPLLAHRNP 273
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLA-IFLYVGAEGAIGDWLPLYLKDVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 274 DGDAAIYGYMLGALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALILLTLGLVDNLWV-LFPVLILGGGCWIGALATY 352
Cdd:COG0738 242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLaLIGLALVGLGLSLMFPTIF 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 489249317 353 NSAVQILVPDwiKARALALYQTALYGGLALGSFLWGHLAETMTVH 397
Cdd:COG0738 322 SLALDGLGKR--TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLR 364
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
60-393 |
2.34e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 65.67 E-value: 2.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 60 VVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFemtgAMFATLLAFLGYLDPVLLIISILWiSL 139
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLL----FILASLLCALASSIEQLLIARFLQ-GL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 140 GGSVTIPAWQAAVNEQVP----ARMVSdavLLNSVNyNVARAAGPALGGLLLSAVGPAWVFLFNS-FCYMALIWAIWQWR 214
Cdd:cd17320 100 GAAAGSVVARAIVRDLYSgaelAKIFS---LLMMIL-AIAPALAPLLGGLLLLFFGWRAIFVFLAlLGLLLLLLVLLFLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 215 --RDVPKRSLPPEGILEGVIAALRftqystvTRLVMMRSFAFGLSASAVWALL---PLLAHRNPDGDAAIYGYMLGALGL 289
Cdd:cd17320 176 etLPEEKRKPLLSSLLRAYKRVLK-------NRRFLGYALALGLSFAGLFAYLaaaPFIYIEQLGLSPAQFGLLFALNAI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 290 GAILGSTQVSRLRQRIGSSRLI------SLAGFTLALILLTLGLVDNLWVLFPVLILGGGCwigALATYNSAVQILVP-D 362
Cdd:cd17320 249 ALILGSLLNGRLVRRFGPRRLLrlglllLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGF---GLIFPNATSLALEPfP 325
|
330 340 350
....*....|....*....|....*....|.
gi 489249317 363 WIKARALALYQTALYGGLALGSFLWGHLAET 393
Cdd:cd17320 326 HVAGTASALLGFLQFLIGALAGALVGLLPNG 356
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
35-386 |
6.76e-11 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 64.13 E-value: 6.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 35 AFRIIWIC--NLFANLGTWAQ-SVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFEMT 111
Cdd:COG2223 3 RWRVLLLAtlAFFLAFGVWYLwSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 112 GAMFATLLaflgyLDPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVG 191
Cdd:COG2223 83 GLLLLALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 192 PAWVFLFNSFCYMALIWAIWQWRRDVPK-RSLPPEGILEGVIAALRftqYSTVTRLVMMRSFAFGlSASAVWALLPLLAH 270
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDPPAgAAAAAKASLRDQLEALR---DPRFWLLSLLYFGTFG-SFIGFSSWLPPYLV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 271 RNPDGDAAIYGYMLGALGLGAILGSTQVSRLRQRIGSSR-LISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGAl 349
Cdd:COG2223 234 DQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRvLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGG- 312
|
330 340 350
....*....|....*....|....*....|....*..
gi 489249317 350 atyNSAVQILVPDWIKARALALYQTALYGGLALGSFL 386
Cdd:COG2223 313 ---NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFL 346
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
79-391 |
1.26e-10 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 63.44 E-value: 1.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 79 ALPLVLLSILSGVIADNHDRrKIMLWGLSFEMTGAMFatLLAFLGYLdPVLLIISILWISLGGsvTIPAWQAAVNEQVPA 158
Cdd:cd17391 46 FLVSAIFSPIWGRLADRYGR-KPMLLRASLGMAIVIG--LMAFVTNV-WQLLILRLLQGVFSG--YVPNATALIASQTPK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 159 RMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLFNS-FCYMALIWAIW----QWRRDVPKRSLPPEGILEGVIA 233
Cdd:cd17391 120 EKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGgLLFLAFLLTLFfvkeDFKPVEKKKMVSTKEVWNSVPN 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 234 AlrftqystvtRLVMMRSFAFGLSASAVWALLPLLA------HRNPDGDAAIYGYMLGALGLGAILGSTQVSRLRQRIGS 307
Cdd:cd17391 200 P----------SLLISLFVTTFIIQLANQSIEPILTlyirqlMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGH 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 308 SRLISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGALATYNSAVQILVPDWIKARALALYQTALYGGLALGSFLW 387
Cdd:cd17391 270 HRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLG 349
|
....
gi 489249317 388 GHLA 391
Cdd:cd17391 350 SAIA 353
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
39-394 |
3.80e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 58.76 E-value: 3.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 39 IWICNLFANLGTWAQSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLsfemtgamFATL 118
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGL--------LIFA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 119 LAFLGYL---DPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWV 195
Cdd:cd17489 73 LATLLYLlatSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 196 FLFNSFCyMALIWAIWQWRRDVPKRslPPEGILEGVIAALRFtqYSTVTRLVMMRSFAFGLSASAVWALLPLLA-HRNPD 274
Cdd:cd17489 153 FIVAAVL-ALLALLLVFLVKDPPPV--AAEEAEAGTRAFRRL--VEKKVLPPALILFLASIAYGAISTFLPLYAaERGIS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 275 GdaaiYGYMLGALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGALATYNS 354
Cdd:cd17489 228 N----AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQA 303
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 489249317 355 AVQILVPDWIKARALALYQTALYGGLALGSFLWGHLAETM 394
Cdd:cd17489 304 LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF 343
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
251-386 |
6.16e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 57.95 E-value: 6.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 251 SFAFGLSASAVWALLPLLAHRNpDGDAAIYGYMLGALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALILLTLGLVDN 330
Cdd:cd17477 5 VALLGLGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 489249317 331 LWVLFPVLILGGGCWIGALATYNSAVQILVPDWIKARALALYQTALYGGLALGSFL 386
Cdd:cd17477 84 PWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL 139
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
42-386 |
1.54e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 56.80 E-value: 1.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 42 CNLFANLGTWAQSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFemtgaMFATLLAF 121
Cdd:cd17477 4 SVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAI-----TAVSVLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 122 LGYLDPVLLII--SILWISLGGS-VTIPAW-QAAVNEQVPARMVSdavllnsvNYNVARAAGPALGGLLLSAVGPAWVFL 197
Cdd:cd17477 79 ALTDSPWVWFLlrFVMGIGLAGLfVVSESWlNALATNENRGRVLG--------LYSTVLGLGFALGPLLLALVGTAGALP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 198 FNSFCYMALIWAIWQWRRDVPKRSLPPEgilegviAALRFTQYSTVTRLVMMRSFAFGLSASAVWALLPLLAHRNPDGDA 277
Cdd:cd17477 151 FLIAAVLLLLALVPLLLTRRAAPEIEEA-------ESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 278 AIyGYMLGALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALILLTLGLVDNL-WVLFPVLILGGGCwigALATYNSAV 356
Cdd:cd17477 224 QA-ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLpLALLVLLFLWGGA---AGPLYTLAL 299
|
330 340 350
....*....|....*....|....*....|
gi 489249317 357 qILVPDWIKARALALYQTALYGGLALGSFL 386
Cdd:cd17477 300 -ALAGDRLPGDELVAANAALLLLYGLGSVI 328
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
43-354 |
2.23e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.45 E-value: 2.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 43 NLFANLGTWAQSVAAAWVVTD-AHASPLMVAMIQVAAALPLVLLSILSGVIADNHD-----RRKIMLWGLsfeMTGAMFA 116
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDvLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGA---IPLALSF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 117 TLLAFLGYLDPV-----LLIISILWISLGGSVTIPaWQAavneqVPARMVSDAVLLNSVNynVARAAGPALGGLLLSAVG 191
Cdd:COG2211 96 VLLFTAPDLSPTgkliyALVTYLLLGLAYTLVNIP-YSA-----LGAELTPDYEERTRLS--SWRFAFAGLGGLLASVLP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 192 PAWVFLF-----NSFCYMALIWAI---------WQWRRDVPKRSLPPEGILEGVIAALRFTQYstvtRLVMMRSFAFGLS 257
Cdd:COG2211 168 PPLVAAFggdaaLGYRLTALIFAVlgllaflltFFGTKERPVPEEEKVSLKESLKALLKNRPF----LLLLLAYLLFFLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 258 ASAVWALLPLLAHRNPDGDAAIYGYMLGALGLGAILGSTQVSRLRQRIGSSR--LISLAGFTLALILLTLGLVDNLWVLF 335
Cdd:COG2211 244 LALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKafIIGLLLAALGLLLLFFLGPGNLWLLL 323
|
330
....*....|....*....
gi 489249317 336 PVLILGGGCWIGALATYNS 354
Cdd:COG2211 324 VLAALAGIGLGAILVLPWA 342
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
35-219 |
4.05e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 55.26 E-value: 4.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 35 AFRIIWICNLFANLGTWA-QSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFemtGA 113
Cdd:COG2271 181 RFWLLALAYFLVYFALYGfLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGL---LL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 114 MFATLLAFLGYLDPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPA 193
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170 180
....*....|....*....|....*.
gi 489249317 194 WVFLFNSFCYMALIWAIWQWRRDVPK 219
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
70-395 |
1.06e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 54.10 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 70 MVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFemtGAMFATLLAFLGylDPVLLIISILWISLGGSVTIPawQ 149
Cdd:cd17478 32 QAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLL---TGLGLSLLGFAP--NYWLLLLLVALAGIGSAAFHP--E 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 150 AAVNeqvpARMVSD-----AVLLNSVNYNVARAAGPALGGLLLSAVG-PAWVFLfnsFCYMALIWAIWQWRRDVPKRSLP 223
Cdd:cd17478 105 GARL----ASQAAGgrrglAMSIFSVGGNLGFALGPLIAAALVALFGgLGLLIL---LIIPGLAVALLLLRLRPLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 224 PEGILEGVIAALRFTQYSTVTRL---VMMRSFAFglsaSAVWALLP-LLAHRNpdGDAAIYGYMLGALGLGAILGSTQVS 299
Cdd:cd17478 178 KKAAAKSSARSTLKGVWRALLLLliiVFLRSWVL----SSLTTFLPfYLVQRG--YSLVFAGLLLSLFLFAGAIGTLIGG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 300 RLRQRIGSSRLIsLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGALATYNSAVQILVPDwikARALAlyqTALYGG 379
Cdd:cd17478 252 PLSDRFGRRRVI-IASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPG---NVGLA---SGLMMG 324
|
330 340
....*....|....*....|.
gi 489249317 380 LA-----LGSFLWGHLAETMT 395
Cdd:cd17478 325 LSfglggIGAPVLGALADAFG 345
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
66-388 |
1.15e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.12 E-value: 1.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 66 ASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLsfemtgaMFATLLAFLGYL--DPVLLIIS--ILWISLGG 141
Cdd:cd17473 32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGL-------LLYGIGGVAGLFldSLYALLASraLLGIGVAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 142 SVTIP-----------------AWQAAVNeqvparmvsdavllnsvnyNVARAAGPALGGLLlSAVGPAWVFLFNSFCYM 204
Cdd:cd17473 105 IMTLAtaligdyfegeerakmlGLQSAAM-------------------SLGGVVFLLLGGAL-AEIGWRAPFLVYLLALP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 205 ALIWAIWQWRRDVPKRSLPPEGILEGVIAALRFTQYstvtrLVMMRSFAFGLSASAVWALLPLLAHRNPDGDAAIYGYML 284
Cdd:cd17473 165 VLILVLLFLPEPARKSKSAASPGAATAAALPWKRVL-----PIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 285 GALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGG-GCWIgALATYNSAVQILVPDW 363
Cdd:cd17473 240 AIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGlGFGL-LLPTLNSWAMSLVPPE 318
|
330 340
....*....|....*....|....*
gi 489249317 364 IKARALALYQTALYGGLALGSFLWG 388
Cdd:cd17473 319 LRGRAMGIVTSAFFLGQFLSPLVLG 343
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
63-390 |
1.31e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 53.74 E-value: 1.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 63 DAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFEMTGamfatlLAFLGYLDPVLLIisILWISLGG- 141
Cdd:cd17330 28 KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS------YVLLGLSRNLWLL--FLARFLDGl 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 142 -SVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLFNSFcyMALIwaiwqwrrdvpkr 220
Cdd:cd17330 100 tGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA--LALL------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 221 slppegileGVIAALRFTqysTVTRLVMMRSFAFGLSASAVWALLPLLAHRNPDGDAAIYGYMLGALGLGAILGSTQV-S 299
Cdd:cd17330 165 ---------NLVLVLFFL---PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLiP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 300 RLRQRIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGALATYNSAVQILVPDWIKARALALYQTALYGG 379
Cdd:cd17330 233 RLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLA 312
|
330
....*....|.
gi 489249317 380 LALGSFLWGHL 390
Cdd:cd17330 313 RIIGPLLAGPL 323
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
65-360 |
2.61e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 52.96 E-value: 2.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 65 HASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGlsfeMTGAMFATLLAFLGYLDPVLLIISILWiSLGGSVT 144
Cdd:cd17503 27 GASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTA----LALFTLGSLLCGLAPNLASLIIFRILQ-GFGGGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 145 IPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLFNsfcymaliwaiwqwrrdvpkrsLPP 224
Cdd:cd17503 102 IPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYIN----------------------LPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 225 eGILEGVIAA---LRFTQYSTVtRLVMMRSFAFGLSASAVWALLPLLAHRNPDGDAAIYGYMLGALGLGAILGSTQVSRL 301
Cdd:cd17503 160 -GILALLLAPlldLRLFKDRNF-TLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRL 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 489249317 302 RQRIGsSRLISLAGFtlalilltlglvdnlwvlfpvLILGGGCWIGALATYNSAVQILV 360
Cdd:cd17503 238 LDKFG-PRLLLLAGL---------------------LLLALGTLLLAFLTPDTSLWLII 274
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-198 |
5.95e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.78 E-value: 5.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 38 IIWICNLFANLGTWaqSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFemtgAMFAT 117
Cdd:cd17324 205 LITFLLFGGFFALY--TYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLL----AAALL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 118 LLAFLGYLDPVLLIISILWiSLGGSVTIPAWQAAVNEQVPaRMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFL 197
Cdd:cd17324 279 LLTLLGPSPLLLLVGLVLW-GLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
|
.
gi 489249317 198 F 198
Cdd:cd17324 357 V 357
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
28-191 |
1.04e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.44 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 28 WAPFSIQAFRIIWICNLFANLGTWAQSVAAAWVVTDA-HASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGL 106
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 107 SFemtGAMFATLLAFLGYLDPVLLIISILWISLGGSVTIPawqaavneqVPARMVSDAV-------------LLNSVNY- 172
Cdd:COG2211 302 LL---AALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILV---------LPWAMLADVVdydewktgrrregLYFGIFTf 369
|
170 180
....*....|....*....|.
gi 489249317 173 --NVARAAGPALGGLLLSAVG 191
Cdd:COG2211 370 aiKLGQALAGALAGLLLALFG 390
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
48-383 |
1.25e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.63 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 48 LGTWAQSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFeMTGAMFATLLAFlgylDP 127
Cdd:cd17321 10 LDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLAL-FGLASLLCALAP----SL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 128 VLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLFNSfcymali 207
Cdd:cd17321 85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 208 waiwqwrrdvpkrslpPEGILeGVIAALRFTqystvtrLVMMRSFAFGLSASAVWALLPLLAHRNPDGDAAIYGYMLGAL 287
Cdd:cd17321 158 ----------------PIGLV-ALLLARTFS-------GAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 288 GLGAILGSTQVSRLRQRIGsSRLISLAGFTLA----LILLTLGLVDNLWVLFPVLILGGGCWIGALATYNSAVQILVPDW 363
Cdd:cd17321 214 ALAMLVAAPLAGRLADRFG-PRLVLVAGLLLTavglLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKE 292
|
330 340
....*....|....*....|
gi 489249317 364 IKARALALYQTALYGGLALG 383
Cdd:cd17321 293 KAGAASGILNTARQLGGALG 312
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
7-180 |
1.31e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.49 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 7 PKHDLPLKPEGQAAKPERTGTWAPFSIQAFRIIWICNLFANLGTWAQSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLS 86
Cdd:pfam07690 173 PPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGR 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 87 ILSGVIADNHDRRKIMLWGLSFemTGAMFATLLAFLGYLDPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVL 166
Cdd:pfam07690 253 LLLGRLSDRLGRRRRLLLALLL--LILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASG 330
|
170
....*....|....
gi 489249317 167 LNSVNYNVARAAGP 180
Cdd:pfam07690 331 LYNTAGSLGGALGP 344
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
63-301 |
1.96e-06 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 51.08 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 63 DAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFEmtgaMFATLLAFLGYL---DPVLLIISILwisL 139
Cdd:PRK08633 41 DGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFE----VGLTLLIVLAYYlgwFWLAFAVTFL---L 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 140 GGSVTI--PAWQAAVNEQVPARMVSDA-VLLNSVNYnVARAAGPALGGLL------------LSAVGPA-WVFLFNSFCY 203
Cdd:PRK08633 114 GAQSAIysPAKYGIIPELVGKENLSRAnGLLEAFTI-VAILAGTALFSFLfesvngntpseiLGRIAPAgLVLLAVAVLG 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 204 MALIWAI-----WQWRRDVPKRSLPPEGILEgviaALRFTQYSTVTRL-VMMRSFAFGLSASAVWALLPLLAHRNPDGDA 277
Cdd:PRK08633 193 LIFAYRLpkvpaAAPEVFDKKKYLFPKLLWR----NLKLLRSDRVLWLaIIGLSYFWFISQLAQANFPAYAKEVLGLDNT 268
|
250 260
....*....|....*....|....
gi 489249317 278 AIYGYMLGALGLGAILGSTQVSRL 301
Cdd:PRK08633 269 FQVQYLLAASAIGIGIGSLLAGRL 292
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
60-211 |
1.37e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 60 VVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFEMTGAMFATLLAFlgylDPVLLIISILWISL 139
Cdd:cd17474 225 LELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVP----SLALLLIAIVLFGL 300
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489249317 140 GGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLFNSFCYMALIWAIW 211
Cdd:cd17474 301 GLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
251-392 |
5.78e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 5.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 251 SFAFGLSASAVWALLPLLAHRNPDGDAAIYGYMLGALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALILLTLGLVDN 330
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489249317 331 LWVLFPVLILGGGcwigALATYNSAVQILVPDWIK----ARALALYQTALYGGLALGSFLWGHLAE 392
Cdd:pfam07690 85 LWLLLVLRVLQGL----GAGALFPAALALIADWFPpeerGRALGLVSAGFGLGAALGPLLGGLLAS 146
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
67-207 |
7.21e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.26 E-value: 7.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 67 SPLMVAMIQVAAALPLVLLSIL-SGVIADNHDRRKIMLWGLSFEMTGAMFATLLAFLGyldpvLLIISILWISLGGSVTI 145
Cdd:cd17330 208 SPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVP-----LLVLAAAILAFGTGIVF 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489249317 146 PAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLFNSFCYMALI 207
Cdd:cd17330 283 PALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIAL 344
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
29-190 |
7.31e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 45.24 E-value: 7.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 29 APFSIQAFRIIWICNLFANLGTWAQSVAAAWVVTDA-HASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLS 107
Cdd:cd17321 163 ALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVlGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 108 FEMTGAMfatLLAFLGYLDPV-LLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLL 186
Cdd:cd17321 243 LTAVGLL---LLALLGADSSVwLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
....
gi 489249317 187 LSAV 190
Cdd:cd17321 320 LTAG 323
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
48-213 |
9.84e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.04 E-value: 9.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 48 LGTWAQSVAAAWVVTDAHASPLMVAMIqvaaaLPLVLLSILSGVIADNHDRRKIMLWGLsfeMTGAMFATLLAFLGYLDP 127
Cdd:TIGR00895 36 MGFAAPAISAEWGLDPVQLGFLFSAGL-----IGMAFGALFFGPLADRIGRRRVLLWSI---LLFSVFTLLCALATNVTQ 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 128 VLLIISILWISLGGsvTIPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLFNSFCYMALI 207
Cdd:TIGR00895 108 LLILRFLAGLGLGG--LMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLL 185
|
....*.
gi 489249317 208 WAIWQW 213
Cdd:TIGR00895 186 LLLMRF 191
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
65-414 |
1.08e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.84 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 65 HASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRK-IMLWGLSFemtGAMFATLLAFLGYLDPVLLIISILWISLGgsv 143
Cdd:cd17370 30 GASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKpLVILGYGL---SALAKPLLALAGSWQLVLLLRILERLGKG--- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 144 tipawqaavnEQVPAR--MVSDAVllNSVNYNVA----RA-------AGPALGGLLL--SAVGPAWVFLFNSFCYMALIW 208
Cdd:cd17370 104 ----------IRTPPRdaLLADAT--PPSGRGKAfglhRAldtlgavLGPLLAALLLylLGGNYRTIFLLAAIPALLALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 209 AIWQWRRDVPKRSLPPEGILEGVIAAL--RFTQYSTVTRLVMMRSFAFglsasavwALLPLLAHRNPDGDAAIYGYMLGA 286
Cdd:cd17370 172 ILLFVVKEYPRPPKLRKKSKKTSLKKLpkAFWLYLLAVALFALGNFSF--------AFLILRAQELGLSAALIPLLYALF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 287 LGLGAiLGSTQVSRLRQRIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGGgCWIGALATYNSA-VQILVPDWIK 365
Cdd:cd17370 244 NLVYA-LAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWG-LYMGAQESIERAaVADLVPAELR 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489249317 366 ARALALYQTALYGGLALGSFLWGHLAETMTVHGALLAAGCLLLASVILL 414
Cdd:cd17370 322 GTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
243-394 |
1.14e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 243 VTRLVMMRSFAFGLSASAVWALLPLLAhRNPDGDAAIYGYMLGALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALIL 322
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489249317 323 LTLGLVDNLWVLFPVLILGGGCWIGALATYNSAVQILVPDWIKARALALYQTALYGGLALGSFLWGHLAETM 394
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
38-211 |
2.52e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 2.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 38 IIWICNLFAN--LGTWAQSVaaawVVTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLsfeMTGAMF 115
Cdd:cd17316 184 LLWFFISFGYygLTTFLPTY----LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGL---ILSGIL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 116 ATLLAFLGYLDPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVllnSVNYNVARAAG---PALGGLLLSAVGP 192
Cdd:cd17316 257 ALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGV---GLSYNLGRLGGggaPPLIALLLASTGG 333
|
170
....*....|....*....
gi 489249317 193 AWVFLFNSFCYMALIWAIW 211
Cdd:cd17316 334 TGVPALILALLAIVALIVA 352
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
20-210 |
1.01e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 41.59 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 20 AKPERTGTWAPFSiQAFRIIWICNLFANLGTWAQSVAAAWVVTDAHAS---PLMVAMI-QVAAALPLVLLSILSGVIADN 95
Cdd:cd17368 206 ARPTRRELFALLA-NNRRIILLGMLLVAGSTVTFYFTTVYTPTYAKTVlglSARDSFLvTLLAGVANFIWAPLGGALSDR 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 96 HDRRKIMLWG--LSFEMTGAMFATLLAflgYLDPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVllnSVNYN 173
Cdd:cd17368 285 IGRRPVLLVItlAALVTLYPVFAWLTA---APSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGF---SLVYA 358
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 489249317 174 VARAA--------GPALGGLLLSAVGPAWVFLFNSFCYMALIWAI 210
Cdd:cd17368 359 LAVAIfggfaqfiVTWLIELTGSPLAPAWYLMGAALLGLLATLML 403
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
72-392 |
3.19e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.24 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 72 AMIQVAAALPLV---LLSILSGVIADNHDRRKIMLWGLsfemtGAMFATLLAFLGYLDPVLLIISILWISLGGSVTIPAW 148
Cdd:COG2807 53 TQAGLLTTLPLLafgLFAPLAPRLARRFGLERTLLLAL-----LLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 149 QAAVNEQVPARmVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLFNS-FCYMALIWAIWQWRRDVPKRSLPPEGi 227
Cdd:COG2807 128 PGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWAlLALLALLLWLPLLRRRPAAAAAAPAA- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 228 lEGVIAALRftqySTVTRLVMMRSFAFGLSASAVWALLP-LLAHRNPDGDAAiyGYMLGALGLGAILGSTQVSRLRQRIG 306
Cdd:COG2807 206 -ASLRSLWR----SPLAWLLTLFFGLQSLLYYAVVAWLPpILRDAGLSAATA--GLLLSLFQLAGIPGSLLVPLLADRLG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 307 SSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGALATYNSAVQILVPDWIKARAL-ALYQTALYGGLALGSF 385
Cdd:COG2807 279 DRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALsGMAQSVGYLLAALGPL 358
|
....*..
gi 489249317 386 LWGHLAE 392
Cdd:COG2807 359 LVGALHD 365
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
299-390 |
4.15e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.87 E-value: 4.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 299 SRLRQRIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGG----GCWIGALatynSAVQILVPDWIKARALALYQT 374
Cdd:cd17335 254 SRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGltfaLVWAAAV----SYASAAAPPGLRATAQGLLQG 329
|
90
....*....|....*..
gi 489249317 375 ALYG-GLALGSFLWGHL 390
Cdd:cd17335 330 LYFGlGGGLGSLIGGYL 346
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
48-370 |
4.57e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.49 E-value: 4.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 48 LGTWAQSVAAAWVVTDAHASPLMVAmiqvaAALPLVLLSILSGVIADNHDRRKIMLWGLSFemtGAMFATLLAFLGYLDP 127
Cdd:cd17365 18 MGFVAPALAQDWGLSPAQLGPVGSA-----ALFGMAIGALLAGPLADRFGRKRVLLVSVAL---FGLFTLLTAFAQSVLQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 128 VLLIISILWISLGGSVtiPAWQAAVNEQVPARMVSDAVLLNSVNYNVARAAGPALGGLLLSAVGPAWVFLFnsfcymali 207
Cdd:cd17365 90 LALLRFLTGLGLGAAM--PNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL--------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 208 waiwqwrrdvpkrslppegileGVIAALRFTQYSTVTRLVMMRSFAFGLSASAVWALLPLLAhRNPDGDAAIYGYMLGAL 287
Cdd:cd17365 159 ----------------------GGVPPLILLPLLRGTLLLWVTFFMGLLLVYLLNSWLPKLM-VEAGYSLSQALTITLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 288 GLGAILGSTQVSRLRQRIGSSR-LISLAGFTLALILLTLGLVDNLWVLFPVLILGGGCWIGALATYNSAVQILVPDWIKA 366
Cdd:cd17365 216 NIGGVIGSLLLGWLADRFGPKRvLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRA 295
|
....
gi 489249317 367 RALA 370
Cdd:cd17365 296 TGVG 299
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-220 |
4.73e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 4.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 13 LKPEGQAAKPERTGTWAPFSIQAFRIIWICnLFANLGTW--AQSVAAAWVVTDAHASPLMVAMIQVAAALPLVLLSILSG 90
Cdd:COG0738 189 IEEEEEEAAGSAASLKSLLKNPRLLLGGLA-IFLYVGAEgaIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGG 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 91 VIADNHDRRKIMLWGLSfemtGAMFATLLAFLGYlDPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAVLLNSV 170
Cdd:COG0738 268 FLLKRFGPVRLLRLSAL----LAAVGLLLALLAP-GPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM 342
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 489249317 171 NYnVARAAGPALGGLLLSAVGPAWVFLFNSFCYMALIWAIWQWRRDVPKR 220
Cdd:COG0738 343 GI-VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
251-392 |
5.19e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.48 E-value: 5.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 251 SFAFGLSASAVWALLPLLAHRnPDGDAAIYGYMLGALGLGAILGSTQVSRLRQRIGSSRLISLAGFTLALILLTLGLVDN 330
Cdd:cd17325 5 LFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489249317 331 LWVLFPVLILGGGCWIGALATYNSAVQILVPDWIKARALALYQTALYGGLALGSFLWGHLAE 392
Cdd:cd17325 84 YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD 145
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
61-392 |
5.86e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 5.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 61 VTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKImlwglsFEMTGAMFATLLAFLGYL--DPVLLIISILWIS 138
Cdd:cd17490 23 AESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKL------FIIIGLLFTVLASLIMILfpSPWGLLIARFLSG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 139 LGGS--VTIPAWQAAVNeqvPARMVSDAV-LLNSVNyNVARAAGPALGGLLLSAVG---PAWVFLFNSFCYMALIWAIwQ 212
Cdd:cd17490 97 IAAAtwVSFTVLYASYF---PPDEAAKAMgLINLVN-NLGQLIAFLIGGLIAEHFGmraPFLLAALAGVLGFILSLFI-K 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 213 WRRDVPKRSLPPEGILEGVIAALRFTQYSTVTRLVMMRSFAFglsasaVWALLPLLAHRNPDGDAAIyGYMLGALGLGAI 292
Cdd:cd17490 172 EERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFST------TFGFTPLIAKQLGASSFQL-GLLSIIYLLPNA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 293 LGSTQVSRLR-QRIGSSRLISLAGFTLALILLTLGLVDNLWVLFPVLILGG-GCWIGALATYNSAVQIlVPDWIKARALA 370
Cdd:cd17490 245 LASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGfGTGILFPLLMSLSIEG-VPAEQRSTAMG 323
|
330 340
....*....|....*....|...
gi 489249317 371 LYQtALYG-GLALGSFLWGHLAE 392
Cdd:cd17490 324 FFQ-AIYAlGMFLGPVLVGIISE 345
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
35-198 |
9.14e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.68 E-value: 9.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 35 AFRIIWICNLFANLGTWAQSVAAAWVvTDAHASPLMVAMIQVAAALPLVLLSILSGVIADNHDRRKIMLWGLSFemtgaM 114
Cdd:cd17370 201 AFWLYLLAVALFALGNFSFAFLILRA-QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLS-----L 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249317 115 FATLLAFLGYLDPVLLIISILWISLGGSVTIPAWQAAVNEQVPARMVSDAV-LLNSVnYNVARAAGPALGGLLLSAVGPA 193
Cdd:cd17370 275 ALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYgLFNTV-VGIGWLLASLIAGYLWDLISPS 353
|
....*
gi 489249317 194 WVFLF 198
Cdd:cd17370 354 AAFLF 358
|
|
| |
