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Conserved domains on  [gi|489249875|ref|WP_003157983|]
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MULTISPECIES: acetyl-CoA carboxylase [Pseudomonas aeruginosa group]

Protein Classification

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit( domain architecture ID 10792873)

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit participates in the carboxylation of the carrier protein and the transfer of the carboxyl group to form malonyl-CoA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
1-80 7.15e-40

biotin carboxyl carrier domain-containing protein;


:

Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 125.90  E-value: 7.15e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249875  1 MAEHNVQSPLPGTFYRKASPDAPPYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVIAS 80
Cdd:PRK07051  1 MAQHEIVSPLPGTFYRRPSPDAPPYVEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEFLVEDGEPVEAGQVLARIEE 80
 
Name Accession Description Interval E-value
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
1-80 7.15e-40

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 125.90  E-value: 7.15e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249875  1 MAEHNVQSPLPGTFYRKASPDAPPYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVIAS 80
Cdd:PRK07051  1 MAQHEIVSPLPGTFYRRPSPDAPPYVEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEFLVEDGEPVEAGQVLARIEE 80
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 2-78 1.87e-24

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 88.80  E-value: 1.87e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489249875   2 AEHNVQSPLPGTFYRKASPDAPPYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVI 78
Cdd:COG0511   59 GGGAVKSPMVGTFYRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVI 135
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 3-78 1.62e-17

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 71.79  E-value: 1.62e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489249875    3 EHNVQSPLPGTFYRKASPDAPPYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVI 78
Cdd:TIGR00531  79 GHIVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVI 154
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 6-78 3.64e-17

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 68.21  E-value: 3.64e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489249875  6 VQSPLPGTFYRkaspdapPYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVI 78
Cdd:cd06850   2 VTAPMPGTVVK-------VLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 4-78 1.47e-11

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 54.14  E-value: 1.47e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489249875   4 HNVQSPLPGTFYRkaSPDAPPYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVI 78
Cdd:pfam00364  1 TEIKSPMIGESVR--EGVVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
 
Name Accession Description Interval E-value
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
1-80 7.15e-40

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 125.90  E-value: 7.15e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489249875  1 MAEHNVQSPLPGTFYRKASPDAPPYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVIAS 80
Cdd:PRK07051  1 MAQHEIVSPLPGTFYRRPSPDAPPYVEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEFLVEDGEPVEAGQVLARIEE 80
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 2-78 1.87e-24

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 88.80  E-value: 1.87e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489249875   2 AEHNVQSPLPGTFYRKASPDAPPYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVI 78
Cdd:COG0511   59 GGGAVKSPMVGTFYRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVI 135
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 3-78 1.62e-17

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 71.79  E-value: 1.62e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489249875    3 EHNVQSPLPGTFYRKASPDAPPYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVI 78
Cdd:TIGR00531  79 GHIVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVI 154
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 6-78 3.64e-17

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 68.21  E-value: 3.64e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489249875  6 VQSPLPGTFYRkaspdapPYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVI 78
Cdd:cd06850   2 VTAPMPGTVVK-------VLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 6-78 1.67e-13

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 63.71  E-value: 1.67e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489249875   6 VQSPLPGTFYRKaspdappYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVI 78
Cdd:PRK09282 525 VTSPMPGTVVKV-------KVKEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEI 590
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 4-78 1.47e-11

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 54.14  E-value: 1.47e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489249875   4 HNVQSPLPGTFYRkaSPDAPPYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVI 78
Cdd:pfam00364  1 TEIKSPMIGESVR--EGVVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 6-79 3.38e-11

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 56.77  E-value: 3.38e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489249875   6 VQSPLPGTFYRKASPDAPPYAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVIA 79
Cdd:PLN02983 200 LKSPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIEAMKLMNEIEADQSGTIVEILAEDGKPVSVDTPLFVIE 273
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
2-79 8.27e-08

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 47.23  E-value: 8.27e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489249875   2 AEHNVQSPLPGTFYRKAspdappyAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVIA 79
Cdd:PRK14040 523 AGEPVTAPLAGNIFKVI-------VTEGQTVAEGDVLLILEAMKMETEIRAAQAGTVRGIAVKEGDAVAVGDTLLTLA 593
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 25-79 5.38e-07

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 45.13  E-value: 5.38e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 489249875   25 YAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVIA 79
Cdd:PRK12999 1091 LVKEGDEVKAGDPLAVIEAMKMETTITAPVDGTVKRVLVKAGDQVEAGDLLVELE 1145
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 6-78 1.52e-06

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 43.91  E-value: 1.52e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489249875    6 VQSPLPGTFYRKAspdappyAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVI 78
Cdd:COG1038  1079 IGAPMPGTVVKVL-------VKEGDEVKKGDPLLTIEAMKMETTITAPRDGTVKEVLVKEGDQVEAGDLLIEL 1144
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 27-79 1.81e-06

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 41.21  E-value: 1.81e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 489249875 27 EVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVIA 79
Cdd:COG0508  25 KEGDTVKEGDPLAEVETDKATMEVPAPAAGVLLEILVKEGDTVPVGAVIAVIA 77
sucB TIGR01347
2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This ...
 28-79 1.89e-05

2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This model describes the TCA cycle 2-oxoglutarate system E2 component, dihydrolipoamide succinyltransferase. It is closely related to the pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase. The seed for this model includes mitochondrial and Gram-negative bacterial forms. Mycobacterial candidates are highly derived, differ in having and extra copy of the lipoyl-binding domain at the N-terminus. They score below the trusted cutoff, but above the noise cutoff and above all examples of dihydrolipoamide acetyltransferase. [Energy metabolism, TCA cycle]


Pssm-ID: 273565 [Multi-domain]  Cd Length: 403  Bit Score: 40.87  E-value: 1.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 489249875   28 VGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVIA 79
Cdd:TIGR01347  24 VGDTVKRDENIVEIETDKVVLEVPSPADGVLQEILFKEGDTVESGQVLAILE 75
PRK05704 PRK05704
2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase;
28-82 5.55e-05

2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase;


Pssm-ID: 235571 [Multi-domain]  Cd Length: 407  Bit Score: 39.43  E-value: 5.55e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489249875  28 VGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVIASAE 82
Cdd:PRK05704  26 PGDAVKRDEVLVEIETDKVVLEVPAPAAGVLSEILAEEGDTVTVGQVLGRIDEGA 80
PLN02226 PLN02226
2-oxoglutarate dehydrogenase E2 component
 29-82 6.83e-05

2-oxoglutarate dehydrogenase E2 component


Pssm-ID: 177871 [Multi-domain]  Cd Length: 463  Bit Score: 39.35  E-value: 6.83e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489249875  29 GQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVIASAE 82
Cdd:PLN02226 116 GERVQADEAIAQIETDKVTIDIASPASGVIQEFLVKEGDTVEPGTKVAIISKSE 169
PRK14042 PRK14042
pyruvate carboxylase subunit B; Provisional
 25-75 8.40e-05

pyruvate carboxylase subunit B; Provisional


Pssm-ID: 172536 [Multi-domain]  Cd Length: 596  Bit Score: 38.93  E-value: 8.40e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489249875  25 YAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVL 75
Cdd:PRK14042 540 HVSAGDEVKAGQAVLVIEAMKMETEIKAPANGVVAEILCQKGDKVTPGQVL 590
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 25-82 1.22e-04

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 38.39  E-value: 1.22e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489249875  25 YAEVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVIASAE 82
Cdd:PRK14875  23 LVQEGDEVEKGDELLDVETDKITNEVEAPAAGTLRRQVAQEGETLPVGALLAVVADAE 80
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 28-82 1.26e-03

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 35.43  E-value: 1.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489249875  28 VGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVIASAE 82
Cdd:PTZ00144  68 VGDYVKEDEVICIIETDKVSVDIRAPASGVITKIFAEEGDTVEVGAPLSEIDTGG 122
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 27-78 2.19e-03

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 33.22  E-value: 2.19e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 489249875 27 EVGQAVEAGSVIGLIEVMKQFSEVQAGQAGVLQAFRVADGEAIEPGQVLAVI 78
Cdd:PRK08225 18 KVGDTVEEGQDVVILESMKMEIPIVAEEAGTVKKINVQEGDFVNEGDVLLEI 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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