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Conserved domains on  [gi|489270149|ref|WP_003177887|]
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MULTISPECIES: carbohydrate ABC transporter permease [Bacillus]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
120-412 1.16e-68

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 219.24  E-value: 1.16e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 120 YPYLISGPSLFILVFAVVFPILFSFALAFTNYNLYHSPParlvDWVGIKTFSEIFTvdiwRSTFLDVLAWTIVWTLVAST 199
Cdd:COG1175   19 AAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPP----EFVGLDNYARLFT----DPRFWNALGNTLLFTVVSVP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 200 LQVGLGILLAVVVNQKeVRFKKIFRTILVLPWAVPGFVTILVFAGLFNDSFGAFNhQILAAFGIDPIPWMTNANWTKLAL 279
Cdd:COG1175   91 LQLVLGLLLALLLNRK-LRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLN-ALLGALGLEPINWLGDPSLALPAV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 280 ILMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLILIAMAPIIITQFTFNFNNFNIIYLFNGGGP 359
Cdd:COG1175  169 IIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGP 248

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489270149 360 avpgstAGGTDILVSWIYKLTMQSSQYSLAAALTILLSVFVISIALWQFRRTN 412
Cdd:COG1175  249 ------GNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLR 295
DUF5683 super family cl40938
Family of unknown function (DUF5683); This is a domain of unknown function found mostly in ...
 5-26 2.08e-04

Family of unknown function (DUF5683); This is a domain of unknown function found mostly in bacteria.


The actual alignment was detected with superfamily member pfam18935:

Pssm-ID: 465918  Cd Length: 151  Bit Score: 41.31  E-value: 2.08e-04
                          10        20
                  ....*....|....*....|...
gi 489270149    5 KKALLLS-IIPGLGQFYNKQWIK 26
Cdd:pfam18935   6 RKAALYSaILPGLGQIYNRKYWK 28
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
120-412 1.16e-68

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 219.24  E-value: 1.16e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 120 YPYLISGPSLFILVFAVVFPILFSFALAFTNYNLYHSPParlvDWVGIKTFSEIFTvdiwRSTFLDVLAWTIVWTLVAST 199
Cdd:COG1175   19 AAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPP----EFVGLDNYARLFT----DPRFWNALGNTLLFTVVSVP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 200 LQVGLGILLAVVVNQKeVRFKKIFRTILVLPWAVPGFVTILVFAGLFNDSFGAFNhQILAAFGIDPIPWMTNANWTKLAL 279
Cdd:COG1175   91 LQLVLGLLLALLLNRK-LRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLN-ALLGALGLEPINWLGDPSLALPAV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 280 ILMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLILIAMAPIIITQFTFNFNNFNIIYLFNGGGP 359
Cdd:COG1175  169 IIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGP 248

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489270149 360 avpgstAGGTDILVSWIYKLTMQSSQYSLAAALTILLSVFVISIALWQFRRTN 412
Cdd:COG1175  249 ------GNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLR 295
malF PRK10999
maltose ABC transporter permease MalF;
164-411 1.62e-55

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 191.33  E-value: 1.62e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 164 WVGIKTFSEIFTVDIWRSTFLDVLAWTIVWTLVASTLQVGLGILLAVVVNQKEVRFKKIFRTILVLPWAVPGFVTILVFA 243
Cdd:PRK10999 264 TIGWKNFTRVFTDEGIQKPFIAIFIWTVVFSLLTVVLTVAVGMVLACLVQWEALKGKAVYRVLLILPYAVPSFISILIFK 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 244 GLFNDSFGAFNHQILAAFGIDPiPWMTNANWTKLALILMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRH 323
Cdd:PRK10999 344 GLFNQSFGEINMMLSALFGIKP-AWFSDPTLAKTMILIVNTWLGYPYMMILCMGLLKAIPDDLYEASAMDGAGPFQNFFK 422

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 324 ITLPLILIAMAPIIITQFTFNFNNFNIIYLFNGGGPAVPGST--AGGTDILVSWIYKLTMQSS---QYSLAAALTILLSV 398
Cdd:PRK10999 423 ITLPLLIKPLTPLMIASFAFNFNNFVLIQLLTNGGPDMIGTTtpAGYTDLLVSYTYRIAFEGGggqDFGLAAAIATLIFL 502

                        250
                 ....*....|...
gi 489270149 399 FVISIALWQFRRT 411
Cdd:PRK10999 503 LVGALAILNLKAT 515
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 187-403 1.20e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 69.23  E-value: 1.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 187 LAWTIVWTLVASTLQVGLGILLAVVVNQKEVRFKKIFRTILVLPWAVPGFVTILVFAGLFNDSFGafnhqilaafgidpi 266
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLG--------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 267 pWMTNANWTKLALILMQGWLgFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLILIAMAPIIITQFTFNFN 346
Cdd:cd06261   66 -WGILPGLGLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALG 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489270149 347 NFNIIYLFNGGGPAVPGstaggtdilvSWIYKLTMQSSQYSLAAALTILLSVFVISI 403
Cdd:cd06261  144 EFALVSFLGGGEAPGPG----------TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 201-411 7.47e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 63.86  E-value: 7.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149  201 QVGLGILLAVVVNqkeVRFKKIFRTILVLPWAVPGFVTILVFAglfndsfgafnhqilaafgidPIPWMTNANWTKLALI 280
Cdd:pfam00528   1 GIPLGIIAALRRG---RRLDRLLRPLIDLLQALPSFVLAILLV---------------------VIAILSILGHGILPAI 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149  281 LMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLILIAMAPIIITQFTFNFNNFNIIYLFNGGGPa 360
Cdd:pfam00528  57 ILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPG- 135

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489270149  361 vpgstAGGTDILVSWIYKLTMQSSQYSLAAALTILLSVFVISIALWQFRRT 411
Cdd:pfam00528 136 -----LGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRV 181
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 123-415 3.52e-07

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 52.38  E-value: 3.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149  123 LISGPSLFILVFAVVfPILFSFALAFTNynlyhsppaRLVDWVGIKTFSEIFTvdiwRSTFLDVLAWTIVWTLVASTLQV 202
Cdd:TIGR03262   6 LLAGMILALLLFLLL-PLLALLTKSVYD---------SDGDFIGLANFAEYFA----TPGLLQSLGNSLTVSAIVTAIVV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149  203 GLGILLAVVVNQKEVRFKKIFRTILVLPWAVP------GFVTILVFAGLFNDSFGAFNhqILAAFGIdpipWMTNANWTk 276
Cdd:TIGR03262  72 PLAFAFAYALTRSRIPGKGAFRLVALLPLLAPsllpaiSLIYLFGNQGLLKGLLGGFS--IYGFWGI----VIGEVFYT- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149  277 lalilmqgwlgFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLI---LIAMAPIIITqftfnfnnfniiYL 353
Cdd:TIGR03262 145 -----------FPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAkygLISAAFVVFT------------LV 201

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489270149  354 FNGGGpaVPGSTAGGTDILVSWIYKLTMQSSQYSLAAALTILL---SVFVISIALWQFRRTNSFK 415
Cdd:TIGR03262 202 ITDFG--VPKVIGGDYNVLATDIYKQVIGQQNFPMGAVVGVLLllpALLAFGIDRAIQRRQRAQL 264
DUF5683 pfam18935
Family of unknown function (DUF5683); This is a domain of unknown function found mostly in ...
 5-26 2.08e-04

Family of unknown function (DUF5683); This is a domain of unknown function found mostly in bacteria.


Pssm-ID: 465918  Cd Length: 151  Bit Score: 41.31  E-value: 2.08e-04
                          10        20
                  ....*....|....*....|...
gi 489270149    5 KKALLLS-IIPGLGQFYNKQWIK 26
Cdd:pfam18935   6 RKAALYSaILPGLGQIYNRKYWK 28
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
120-412 1.16e-68

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 219.24  E-value: 1.16e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 120 YPYLISGPSLFILVFAVVFPILFSFALAFTNYNLYHSPParlvDWVGIKTFSEIFTvdiwRSTFLDVLAWTIVWTLVAST 199
Cdd:COG1175   19 AAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPP----EFVGLDNYARLFT----DPRFWNALGNTLLFTVVSVP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 200 LQVGLGILLAVVVNQKeVRFKKIFRTILVLPWAVPGFVTILVFAGLFNDSFGAFNhQILAAFGIDPIPWMTNANWTKLAL 279
Cdd:COG1175   91 LQLVLGLLLALLLNRK-LRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLN-ALLGALGLEPINWLGDPSLALPAV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 280 ILMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLILIAMAPIIITQFTFNFNNFNIIYLFNGGGP 359
Cdd:COG1175  169 IIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGP 248

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489270149 360 avpgstAGGTDILVSWIYKLTMQSSQYSLAAALTILLSVFVISIALWQFRRTN 412
Cdd:COG1175  249 ------GNSTTTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLR 295
malF PRK10999
maltose ABC transporter permease MalF;
164-411 1.62e-55

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 191.33  E-value: 1.62e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 164 WVGIKTFSEIFTVDIWRSTFLDVLAWTIVWTLVASTLQVGLGILLAVVVNQKEVRFKKIFRTILVLPWAVPGFVTILVFA 243
Cdd:PRK10999 264 TIGWKNFTRVFTDEGIQKPFIAIFIWTVVFSLLTVVLTVAVGMVLACLVQWEALKGKAVYRVLLILPYAVPSFISILIFK 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 244 GLFNDSFGAFNHQILAAFGIDPiPWMTNANWTKLALILMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRH 323
Cdd:PRK10999 344 GLFNQSFGEINMMLSALFGIKP-AWFSDPTLAKTMILIVNTWLGYPYMMILCMGLLKAIPDDLYEASAMDGAGPFQNFFK 422

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 324 ITLPLILIAMAPIIITQFTFNFNNFNIIYLFNGGGPAVPGST--AGGTDILVSWIYKLTMQSS---QYSLAAALTILLSV 398
Cdd:PRK10999 423 ITLPLLIKPLTPLMIASFAFNFNNFVLIQLLTNGGPDMIGTTtpAGYTDLLVSYTYRIAFEGGggqDFGLAAAIATLIFL 502

                        250
                 ....*....|...
gi 489270149 399 FVISIALWQFRRT 411
Cdd:PRK10999 503 LVGALAILNLKAT 515
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 129-405 2.23e-31

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 121.74  E-value: 2.23e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 129 LFILVFAVVFPILFSFA------LAFTNYN----LYHSPparlvdWVGIKTFSEIFTvdiwrstflDVLAWTIVW-TLVA 197
Cdd:COG4209   30 YLMLLPGLIYLLIFSYLpmygivIAFKDYNpfkgIFGSP------WVGLKNFKFLFS---------SPDFWRVLRnTLLI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 198 STLQVGLG----ILLAVVVNQ-KEVRFKKIFRTILVLP----WAVpgfVTILVFAgLFNDSFGAFNhQILAAFGIDPIPW 268
Cdd:COG4209   95 SLLKLVFGfplpIILALLLNElRSKRFKKTVQTISYLPhflsWVV---VAGIVYQ-FLSPDTGLVN-QLLRALGGEPINF 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 269 MTNANWTKLALILMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLILiamaPIIITQftfnfnnf 348
Cdd:COG4209  170 LTEPKYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGIR----PTIVIL-------- 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489270149 349 NI-------------IYLF-NGGGPAVpgstaggTDILVSWIYKLTMQSSQYSLAAALTILLSvfVISIAL 405
Cdd:COG4209  238 LIlnignilnvgfeqIYLLyNPLNYST-------SDVIDTYVYRIGLQNGDYSYATAVGLFKS--VVGLIL 299
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
121-409 9.87e-23

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 100.24  E-value: 9.87e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 121 PYLISGPSLFILVFAVVFPILFSFALAFTnynlyhspparlvdwVGIKTFSEIFtvdiWRSTFLDVLAWTIVWTLVASTL 200
Cdd:COG1178    9 PRLLLLLLALLLALLVLLPLLALLLRAFT---------------DGLANFWALL----SDPYLWRALGNTLLLALLVTLL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 201 QVGLGILLAVVVNQKEVRFKKIFRTILVLPWAVPGFVTILVFAGLFNDSfGAFNHQILAAFGIDPIPWMTNAnwtklALI 280
Cdd:COG1178   70 SLLLGVPLAWLLARTDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPN-GLLNTLLRALFGLEPPDIYGLG-----GII 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 281 LMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLILIAMAPIIItqftfnfnnfnIIYLFNGGGPA 360
Cdd:COG1178  144 LVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGAL-----------LVFLLCLADFG 212

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 489270149 361 VPGSTAGGTDILVSWIYKLTMQSSQYSLAAALTILLSVFVISIALWQFR 409
Cdd:COG1178  213 TPLVLGGGYTTLTTAIYQAWLGDFDLGAAAALALVLLLLVLLLLLLERR 261
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 121-412 1.55e-17

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 82.12  E-value: 1.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 121 PYLISGPSLFILVFAVVFPILFSFALAFTNYNLYHSPPARLvdwvGIKTFSEIFTvdiwRSTFLDVLAWTIVWTLVASTL 200
Cdd:COG1176   11 PLLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYGGVVPGF----TLENYARLFT----DPLYLKVLLRTLWIALLTTLI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 201 QVGLGILLAVVVNQKEVRFKKIFRTILVLPWAVPGFVTILVFAGLFNDSfGAFNhQILAAFGI--DPIPWMtnanWTKLA 278
Cdd:COG1176   83 CLLLGYPIAYFLARAPPRWRNLLLLLVILPFWTSFLVRTYAWIVLLGRN-GLLN-SLLLALGLidEPLRLL----YTEFA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 279 LILMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLiliAMAPIIITqftfnfnnFNIIYLFNGGG 358
Cdd:COG1176  157 VVIGLVYVYLPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPL---SLPGIIAG--------SLLVFIPALGA 225

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489270149 359 PAVPGSTAGGTDILVS-WIYKLTMQSSQYSLAAALTILLSVFVISIALWQFRRTN 412
Cdd:COG1176  226 FVTPALLGGGKVLMIGnLIYQQFLSALNWPLAAALAVVLLLIVLLVLLLYLRLLR 280
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
164-409 6.66e-15

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 74.48  E-value: 6.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 164 WVGIKTFSEIFTVDIWRSTFldvlaWTivwTLVASTLQVGLGIL----LAVVVNQKeVRFKKIFRTILVLPWAVPGFVTI 239
Cdd:PRK10561  38 FVGLDNFVALFHDSYYLDSF-----WT---TIKFSTLVTVSGLLvslfFAALVDYV-VRGSRFYQTLMLLPYAVAPAVAA 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 240 LVFAGLFNDSFGAFNHqILAAFGIDpipW--MTNANWTKLALILMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASA 317
Cdd:PRK10561 109 VLWIFLFNPGRGLITH-FLAEFGYD---WnhAQNSGQAMFLVVFASVWKQISYNFLFFFAALQSIPRSLVEAAAIDGAGP 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 318 FSKFRHITLPLIliamAPIiitqfTFNFNNFNIIYLFNGGGPAVPGSTAGG----TDILVSWIYKLTMQSSQYSLAAALT 393
Cdd:PRK10561 185 IRRFFKLALPLI----APV-----SFFLLVVNLVYAFFDTFPVIDAATSGGpvqaTTTLIYKIYREGFTGLDLSSSAAQS 255

                        250
                 ....*....|....*.
gi 489270149 394 ILLSVFVISIALWQFR 409
Cdd:PRK10561 256 VVLMFLVIVLTVVQFR 271
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 187-403 1.20e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 69.23  E-value: 1.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 187 LAWTIVWTLVASTLQVGLGILLAVVVNQKEVRFKKIFRTILVLPWAVPGFVTILVFAGLFNDSFGafnhqilaafgidpi 266
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLG--------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 267 pWMTNANWTKLALILMQGWLgFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLILIAMAPIIITQFTFNFN 346
Cdd:cd06261   66 -WGILPGLGLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALG 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489270149 347 NFNIIYLFNGGGPAVPGstaggtdilvSWIYKLTMQSSQYSLAAALTILLSVFVISI 403
Cdd:cd06261  144 EFALVSFLGGGEAPGPG----------TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 129-330 2.86e-13

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 69.37  E-value: 2.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 129 LFILVFAVVF-PILFSFALAFTNYNLYHSPPARL-VDWvgiktFSEIFTvdiwRSTFLDVLAWTIVWTLVASTLQVGLGI 206
Cdd:COG1177   12 FLALVLLFLYlPILVLVLYSFNDSWFLTFPPEGFtLRW-----YAELFS----DPRLLDALLNSLLIALLSTLLATVLGT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 207 LLAVVVNQKEVRFKKIFRTILVLPWAVPGFVTILVFAGLFndsfgafnhqilAAFGIDPIPWmtnanwtklALILMQGWL 286
Cdd:COG1177   83 PAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLF------------SALGLSGGLW---------GLILAHVVF 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 489270149 287 GFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLIL 330
Cdd:COG1177  142 TLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIA 185
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 122-334 3.52e-13

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 69.39  E-value: 3.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 122 YLISGPSLFILVFAVVFPILFSFALAFTnynlyhspparlvdwVGIKTFSEIFTVDIwrstFLDVLAWTIVWTLVASTLQ 201
Cdd:COG0555   10 GLTLGLTLLYLSLIVLLPLAALVLKAAG---------------LGWAEFWAVLTSPR----VLAALKLSLGTALIAALIN 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 202 VGLGILLAVVVNQKEVRFKKIFRTILVLPWAVPGFVTILVFAGLFNDSfGAFNhQILAAFGIDPIpwmtnanWTKLALIL 281
Cdd:COG0555   71 LVFGLPLAWVLVRYRFPGKRLVDALVDLPFALPTAVAGIALLLLFGPN-GWLG-QLLAPLGIKVA-------FTPLGIVL 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489270149 282 MQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLILIAMA 334
Cdd:COG0555  142 AQTFVSLPFVVRTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALL 194
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 129-339 9.31e-13

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 68.20  E-value: 9.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 129 LFILVFAVVFPILFSFALAF-TNYNLYHSPPARLVDWVGIKTFSEIFTvdiwRSTFLDVLAWTIVWTLVASTLQVGLGIL 207
Cdd:COG0395   21 LILLALLFLFPLYWMVVTSFkPPAEIFSGPPSLLPSEFTLENYRAAFT----DGPFGRYLLNSLIVAVVSTVLSLLLSSL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 208 LAVVVNQKEVRFKKIFRTILVLPWAVPGFVTILvfaGLFndsfgafnhQILAAFGidpipwMTNanwTKLALILMQGWLG 287
Cdd:COG0395   97 AAYALARFRFRGRKLLFLLILATLMIPGQVLLI---PLY---------LLFRQLG------LLN---TYWGLILPYLAFG 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489270149 288 FPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLiliaMAPIIIT 339
Cdd:COG0395  156 LPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPL----SKPALAT 203
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 201-411 7.47e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 63.86  E-value: 7.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149  201 QVGLGILLAVVVNqkeVRFKKIFRTILVLPWAVPGFVTILVFAglfndsfgafnhqilaafgidPIPWMTNANWTKLALI 280
Cdd:pfam00528   1 GIPLGIIAALRRG---RRLDRLLRPLIDLLQALPSFVLAILLV---------------------VIAILSILGHGILPAI 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149  281 LMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLILIAMAPIIITQFTFNFNNFNIIYLFNGGGPa 360
Cdd:pfam00528  57 ILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPG- 135

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489270149  361 vpgstAGGTDILVSWIYKLTMQSSQYSLAAALTILLSVFVISIALWQFRRT 411
Cdd:pfam00528 136 -----LGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRV 181
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
126-334 4.60e-11

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 64.41  E-value: 4.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 126 GPSLFILVFAVVFPILFSFALaftnynlyhsPPARLVDWVGIKTFSEIFTVDIWRSTFLDVLAWTIVWT-----LVASTL 200
Cdd:COG1178  284 GRWRWLALALCLLLVLLGLLL----------PLLALLLWSLTKALDDNLTLDNYRFVLLDPSLLRALLNslllaLLAALL 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 201 QVGLGILLAVVVNQKEVRFKKIFRTILVLPWAVPGFVTILVFAGLFNDSFGafnhqilaafgidpiPWMTNanwTKLALI 280
Cdd:COG1178  354 AVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVPGIVLGLGLLLLFNRPLP---------------LLLYG---TLAILV 415

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489270149 281 LMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLILIAMA 334
Cdd:COG1178  416 LAYVVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLL 469
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 129-340 2.87e-08

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 54.77  E-value: 2.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 129 LFILVFAVVFPILFSFALAFTNYNLYHSPPArLVDWVGIKTFSEIFTvdiwRSTFLDVLAWTIVWTLVASTLQVGLGILL 208
Cdd:COG3833   22 LIILAIIALFPILWVVSASFNPGGSLYSSSL-IPENFTLENYKKLFT----ETPFLRWFLNSLIVAVVTAIISVFLAALA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 209 AVVVNQKEVRFKKIFRTILVLPWAVPGFVTILVFAGLFnDSFGAFNhqilaafgidpipwmtnanwTKLALILMQGWLGF 288
Cdd:COG3833   97 AYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLL-SALGLLN--------------------TLLGLILVYLGGAI 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489270149 289 PYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLiliaMAPIIITQ 340
Cdd:COG3833  156 PFNTWLMKGYFDTIPKELDEAAKIDGASHFQIFFRIILPL----AKPILAVV 203
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 123-415 3.52e-07

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 52.38  E-value: 3.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149  123 LISGPSLFILVFAVVfPILFSFALAFTNynlyhsppaRLVDWVGIKTFSEIFTvdiwRSTFLDVLAWTIVWTLVASTLQV 202
Cdd:TIGR03262   6 LLAGMILALLLFLLL-PLLALLTKSVYD---------SDGDFIGLANFAEYFA----TPGLLQSLGNSLTVSAIVTAIVV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149  203 GLGILLAVVVNQKEVRFKKIFRTILVLPWAVP------GFVTILVFAGLFNDSFGAFNhqILAAFGIdpipWMTNANWTk 276
Cdd:TIGR03262  72 PLAFAFAYALTRSRIPGKGAFRLVALLPLLAPsllpaiSLIYLFGNQGLLKGLLGGFS--IYGFWGI----VIGEVFYT- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149  277 lalilmqgwlgFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLI---LIAMAPIIITqftfnfnnfniiYL 353
Cdd:TIGR03262 145 -----------FPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAkygLISAAFVVFT------------LV 201

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489270149  354 FNGGGpaVPGSTAGGTDILVSWIYKLTMQSSQYSLAAALTILL---SVFVISIALWQFRRTNSFK 415
Cdd:TIGR03262 202 ITDFG--VPKVIGGDYNVLATDIYKQVIGQQNFPMGAVVGVLLllpALLAFGIDRAIQRRQRAQL 264
cysT CHL00187
sulfate transport protein; Provisional
 190-333 6.30e-06

sulfate transport protein; Provisional


Pssm-ID: 214388 [Multi-domain]  Cd Length: 237  Bit Score: 47.32  E-value: 6.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 190 TIVWTLVASTLQVGLGILLAVVVNQKEVRFKKIFRTILVLPWAVPGFVTILVFAGLFNDSfGAFNHqILAAFGIDPIpwm 269
Cdd:CHL00187  60 TLSMALIAALINGFFGLLIAWVLVRYNFPGKRLLDAAVDLPFALPTSVAGLTLATVYGDN-GWIGH-LLSHLGIQIV--- 134

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489270149 270 tnanWTKLALILMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLPLILIAM 333
Cdd:CHL00187 135 ----FTKLGVLLAMIFVSFPFVVRTIQPVLQEIEKELEEAAWSLGASPWQTFWKVIFPPLIPAL 194
DUF5683 pfam18935
Family of unknown function (DUF5683); This is a domain of unknown function found mostly in ...
 5-26 2.08e-04

Family of unknown function (DUF5683); This is a domain of unknown function found mostly in bacteria.


Pssm-ID: 465918  Cd Length: 151  Bit Score: 41.31  E-value: 2.08e-04
                          10        20
                  ....*....|....*....|...
gi 489270149    5 KKALLLS-IIPGLGQFYNKQWIK 26
Cdd:pfam18935   6 RKAALYSaILPGLGQIYNRKYWK 28
PRK10971 PRK10971
sulfate/thiosulfate ABC transporter permease CysT;
196-327 9.41e-03

sulfate/thiosulfate ABC transporter permease CysT;


Pssm-ID: 182873  Cd Length: 277  Bit Score: 37.81  E-value: 9.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489270149 196 VASTLQVGLGILLAVVVNQKEVRFKKIFRTILVLPWAVPGFVTILVFAGLFndSFGAFNHQILAAFGIdpipwmtNANWT 275
Cdd:PRK10971  69 VASIFNAVFGLLMAWILTRYRFPGRTLLDALMDLPFALPTAVAGLTLASLF--SVNGWYGEWLAKFDI-------KVTYT 139

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489270149 276 KLALILMQGWLGFPYVFIVTTGVLQSIPDDLYEAATIDGASAFSKFRHITLP 327
Cdd:PRK10971 140 WLGIAVAMAFTSIPFVVRTVQPVLEELGPEYEEAAETLGATRWQSFRKVVLP 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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