NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489277460|ref|WP_003185136|]
View 

MULTISPECIES: flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [Pseudomonas]

Protein Classification

flavodoxin/ferredoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase( domain architecture ID 10011395)

flavodoxin/ferredoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate, part of an alternative non-mevalonate pathway for isoprenoid biosynthesis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
1-358 0e+00

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


:

Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 649.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   1 MHGESPIKRRESRKIWVGNVPVGGDAPIAVQSMTNSDTNDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKIKQLVK 80
Cdd:PRK00366   1 MRPSTPIPRRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQLP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  81 VPLVADIHFDYRIALRVAELGVDCLRINPGNIG-REDRVRAVVDAARDRGIPIRIGVNAGSLEKDLQKKYGEPTPAALVE 159
Cdd:PRK00366  81 VPLVADIHFDYRLALAAAEAGADALRINPGNIGkRDERVREVVEAAKDYGIPIRIGVNAGSLEKDLLEKYGEPTPEALVE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 160 SALRHVEHLERLNFQDFKVSVKASDVFMAVEAYRLLAKEIVQPLHLGITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRIS 239
Cdd:PRK00366 161 SALRHAKILEELGFDDIKISVKASDVQDLIAAYRLLAKRCDYPLHLGVTEAGMGFKGTVKSAAGLGALLQEGIGDTIRVS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 240 LAADPVEEVKVGYDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDLLVPLDVAVIGCVVNGPGEAKEAHIG 319
Cdd:PRK00366 241 LTADPVEEVKVGQEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEHIKMPLKVAVMGCVVNGPGEAKEADIG 320
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 489277460 320 LTGGTP-NLIYIDGKPSQKLTNDNLVDELERLIRQKAAEK 358
Cdd:PRK00366 321 IAGGNPkGPVFVDGEKIKTLPEENIVEELEAEIEAYAEER 360
 
Name Accession Description Interval E-value
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
1-358 0e+00

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 649.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   1 MHGESPIKRRESRKIWVGNVPVGGDAPIAVQSMTNSDTNDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKIKQLVK 80
Cdd:PRK00366   1 MRPSTPIPRRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQLP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  81 VPLVADIHFDYRIALRVAELGVDCLRINPGNIG-REDRVRAVVDAARDRGIPIRIGVNAGSLEKDLQKKYGEPTPAALVE 159
Cdd:PRK00366  81 VPLVADIHFDYRLALAAAEAGADALRINPGNIGkRDERVREVVEAAKDYGIPIRIGVNAGSLEKDLLEKYGEPTPEALVE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 160 SALRHVEHLERLNFQDFKVSVKASDVFMAVEAYRLLAKEIVQPLHLGITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRIS 239
Cdd:PRK00366 161 SALRHAKILEELGFDDIKISVKASDVQDLIAAYRLLAKRCDYPLHLGVTEAGMGFKGTVKSAAGLGALLQEGIGDTIRVS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 240 LAADPVEEVKVGYDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDLLVPLDVAVIGCVVNGPGEAKEAHIG 319
Cdd:PRK00366 241 LTADPVEEVKVGQEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEHIKMPLKVAVMGCVVNGPGEAKEADIG 320
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 489277460 320 LTGGTP-NLIYIDGKPSQKLTNDNLVDELERLIRQKAAEK 358
Cdd:PRK00366 321 IAGGNPkGPVFVDGEKIKTLPEENIVEELEAEIEAYAEER 360
IspG COG0821
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism] ...
4-363 0e+00

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440583 [Multi-domain]  Cd Length: 363  Bit Score: 645.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   4 ESPIKRRESRKIWVGNVPVGGDAPIAVQSMTNSDTNDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKIKQLVKVPL 83
Cdd:COG0821    3 SSPIPRRKTRQVRVGNVAIGGGAPISVQSMTNTDTADVEATVAQIKALAEAGCEIVRVAVPDEEAAAALPEIKKQLPVPL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  84 VADIHFDYRIALRVAELGVDCLRINPGNIGREDRVRAVVDAARDRGIPIRIGVNAGSLEKDLQKKYGEPTPAALVESALR 163
Cdd:COG0821   83 VADIHFDYRLALEAAEAGVDKLRINPGNIGSDEKVREVVEAAKERGIPIRIGVNAGSLEKDLLEKYGDPTPEALVESALE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 164 HVEHLERLNFQDFKVSVKASDVFMAVEAYRLLAKEIVQPLHLGITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRISLAAD 243
Cdd:COG0821  163 HARILEELGFDDIKISLKASDVQDTIAAYRLLAERCDYPLHLGVTEAGTGRKGTVKSAAGLGILLAEGIGDTIRVSLTAD 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 244 PVEEVKVGYDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDLLVPLDVAVIGCVVNGPGEAKEAHIGLTGG 323
Cdd:COG0821  243 PVEEVKVAQEILKSLGLRSRGPEVISCPTCGRTEIDLIQLAEEVEERLRDIKEPLKVAVMGCVVNGPGEAKEADIGIAGG 322
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 489277460 324 TP-NLIYIDGKPSQKLTNDNLVDELERLIRQKAAEKVEADA 363
Cdd:COG0821  323 GGeGLLFKKGEIIRKVPEDEIVEELLEEIEKYVAERYGEGA 363
GcpE pfam04551
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids ...
12-353 0e+00

GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.


Pssm-ID: 428003 [Multi-domain]  Cd Length: 343  Bit Score: 615.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   12 SRKIWVGNVPVGGDAPIAVQSMTNSDTNDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKIKQLVKVPLVADIHFDY 91
Cdd:pfam04551   1 TRQVRVGNVPIGGGAPIVVQSMTNTDTRDVEATVAQIRRLAEAGCEIVRVAVPDMEAAEALKEIKKRLPIPLVADIHFDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   92 RIALRVAELGVDCLRINPGNIGREDRVRAVVDAARDRGIPIRIGVNAGSLEKDLQKKYGEPTPAALVESALRHVEHLERL 171
Cdd:pfam04551  81 RLALEAAEAGVDKIRINPGNIGSEEKVREVVEAAKERGIPIRIGVNSGSLEKDLLEKYGGPTPEALVESALEHVRILEEL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  172 NFQDFKVSVKASDVFMAVEAYRLLAKEIVQPLHLGITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRISLAADPVEEVKVG 251
Cdd:pfam04551 161 GFDDIVISLKASDVPLTVEAYRLLAERCDYPLHLGVTEAGTGESGTIKSAVGIGALLAEGIGDTIRVSLTGDPVEEVKVA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  252 YDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDLLVPLDVAVIGCVVNGPGEAKEAHIGLTGGTP-NLIYI 330
Cdd:pfam04551 241 KEILQSLGLRKRGVEIISCPTCGRTEIDLIELAEEVEERLEHLKKPLKVAVMGCVVNGPGEAKEADIGIAGGKGeGLLFK 320
                         330       340
                  ....*....|....*....|...
gi 489277460  331 DGKPSQKLTNDNLVDELERLIRQ 353
Cdd:pfam04551 321 KGEIVRKVPEEELVEELLEEIEK 343
ispG_gcpE TIGR00612
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown ...
9-351 1.54e-164

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273174 [Multi-domain]  Cd Length: 346  Bit Score: 463.82  E-value: 1.54e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460    9 RRESRKIWVGNVPVGGDAPIAVQSMTNSDTNDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKIKQLVKVPLVADIH 88
Cdd:TIGR00612   1 RRKTRQVRVGNVKVGGDAPIVVQSMTNTDTHDVDATVAQIRRLEEAGCEIVRVTVPDKESAEALEEIKEGSNVPLVADIH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   89 FDYRIALRVAELGVDCLRINPGNIGREDRVRAVVDAARDRGIPIRIGVNAGSLEKDLQKKYGEPTPAALVESALRHVEHL 168
Cdd:TIGR00612  81 FAYSYAALAMAKGVAKVRINPGNIGFEERVRDIVEKARRHGKAMRIGVNHGSLERRLLEKYGDPTAEAMVQSALEWAEIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  169 ERLNFQDFKVSVKASDVFMAVEAYRLLAKEIVQPLHLGITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRISLAADPVEEV 248
Cdd:TIGR00612 161 EKLGFRNVVVSMKASDVLQTVAAYRLLAERSDYPLHLGVTEAGMGVKGIIKSSVGIGILLAMGIGDTIRVSLTDDPVVEV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  249 KVGYDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDLLVPLDVAVIGCVVNGPGEAKEAHIGLTGGTPNLI 328
Cdd:TIGR00612 241 PVAYEILQSLGLRRRGVEIVACPSCGRTGFDLEKVVKEVQEALSHLKTPLKVAVMGCVVNGPGEAKHADIGISGPGTGFA 320
                         330       340
                  ....*....|....*....|....*
gi 489277460  329 --YIDGKPSQKLTNDNLVDELERLI 351
Cdd:TIGR00612 321 wlFKHGKPKAKVPETDMVDELIKLI 345
 
Name Accession Description Interval E-value
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
1-358 0e+00

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 649.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   1 MHGESPIKRRESRKIWVGNVPVGGDAPIAVQSMTNSDTNDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKIKQLVK 80
Cdd:PRK00366   1 MRPSTPIPRRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQLP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  81 VPLVADIHFDYRIALRVAELGVDCLRINPGNIG-REDRVRAVVDAARDRGIPIRIGVNAGSLEKDLQKKYGEPTPAALVE 159
Cdd:PRK00366  81 VPLVADIHFDYRLALAAAEAGADALRINPGNIGkRDERVREVVEAAKDYGIPIRIGVNAGSLEKDLLEKYGEPTPEALVE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 160 SALRHVEHLERLNFQDFKVSVKASDVFMAVEAYRLLAKEIVQPLHLGITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRIS 239
Cdd:PRK00366 161 SALRHAKILEELGFDDIKISVKASDVQDLIAAYRLLAKRCDYPLHLGVTEAGMGFKGTVKSAAGLGALLQEGIGDTIRVS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 240 LAADPVEEVKVGYDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDLLVPLDVAVIGCVVNGPGEAKEAHIG 319
Cdd:PRK00366 241 LTADPVEEVKVGQEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEHIKMPLKVAVMGCVVNGPGEAKEADIG 320
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 489277460 320 LTGGTP-NLIYIDGKPSQKLTNDNLVDELERLIRQKAAEK 358
Cdd:PRK00366 321 IAGGNPkGPVFVDGEKIKTLPEENIVEELEAEIEAYAEER 360
IspG COG0821
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism] ...
4-363 0e+00

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440583 [Multi-domain]  Cd Length: 363  Bit Score: 645.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   4 ESPIKRRESRKIWVGNVPVGGDAPIAVQSMTNSDTNDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKIKQLVKVPL 83
Cdd:COG0821    3 SSPIPRRKTRQVRVGNVAIGGGAPISVQSMTNTDTADVEATVAQIKALAEAGCEIVRVAVPDEEAAAALPEIKKQLPVPL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  84 VADIHFDYRIALRVAELGVDCLRINPGNIGREDRVRAVVDAARDRGIPIRIGVNAGSLEKDLQKKYGEPTPAALVESALR 163
Cdd:COG0821   83 VADIHFDYRLALEAAEAGVDKLRINPGNIGSDEKVREVVEAAKERGIPIRIGVNAGSLEKDLLEKYGDPTPEALVESALE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 164 HVEHLERLNFQDFKVSVKASDVFMAVEAYRLLAKEIVQPLHLGITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRISLAAD 243
Cdd:COG0821  163 HARILEELGFDDIKISLKASDVQDTIAAYRLLAERCDYPLHLGVTEAGTGRKGTVKSAAGLGILLAEGIGDTIRVSLTAD 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 244 PVEEVKVGYDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDLLVPLDVAVIGCVVNGPGEAKEAHIGLTGG 323
Cdd:COG0821  243 PVEEVKVAQEILKSLGLRSRGPEVISCPTCGRTEIDLIQLAEEVEERLRDIKEPLKVAVMGCVVNGPGEAKEADIGIAGG 322
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 489277460 324 TP-NLIYIDGKPSQKLTNDNLVDELERLIRQKAAEKVEADA 363
Cdd:COG0821  323 GGeGLLFKKGEIIRKVPEDEIVEELLEEIEKYVAERYGEGA 363
GcpE pfam04551
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids ...
12-353 0e+00

GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.


Pssm-ID: 428003 [Multi-domain]  Cd Length: 343  Bit Score: 615.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   12 SRKIWVGNVPVGGDAPIAVQSMTNSDTNDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKIKQLVKVPLVADIHFDY 91
Cdd:pfam04551   1 TRQVRVGNVPIGGGAPIVVQSMTNTDTRDVEATVAQIRRLAEAGCEIVRVAVPDMEAAEALKEIKKRLPIPLVADIHFDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   92 RIALRVAELGVDCLRINPGNIGREDRVRAVVDAARDRGIPIRIGVNAGSLEKDLQKKYGEPTPAALVESALRHVEHLERL 171
Cdd:pfam04551  81 RLALEAAEAGVDKIRINPGNIGSEEKVREVVEAAKERGIPIRIGVNSGSLEKDLLEKYGGPTPEALVESALEHVRILEEL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  172 NFQDFKVSVKASDVFMAVEAYRLLAKEIVQPLHLGITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRISLAADPVEEVKVG 251
Cdd:pfam04551 161 GFDDIVISLKASDVPLTVEAYRLLAERCDYPLHLGVTEAGTGESGTIKSAVGIGALLAEGIGDTIRVSLTGDPVEEVKVA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  252 YDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDLLVPLDVAVIGCVVNGPGEAKEAHIGLTGGTP-NLIYI 330
Cdd:pfam04551 241 KEILQSLGLRKRGVEIISCPTCGRTEIDLIELAEEVEERLEHLKKPLKVAVMGCVVNGPGEAKEADIGIAGGKGeGLLFK 320
                         330       340
                  ....*....|....*....|...
gi 489277460  331 DGKPSQKLTNDNLVDELERLIRQ 353
Cdd:pfam04551 321 KGEIVRKVPEEELVEELLEEIEK 343
ispG_gcpE TIGR00612
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown ...
9-351 1.54e-164

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273174 [Multi-domain]  Cd Length: 346  Bit Score: 463.82  E-value: 1.54e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460    9 RRESRKIWVGNVPVGGDAPIAVQSMTNSDTNDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKIKQLVKVPLVADIH 88
Cdd:TIGR00612   1 RRKTRQVRVGNVKVGGDAPIVVQSMTNTDTHDVDATVAQIRRLEEAGCEIVRVTVPDKESAEALEEIKEGSNVPLVADIH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   89 FDYRIALRVAELGVDCLRINPGNIGREDRVRAVVDAARDRGIPIRIGVNAGSLEKDLQKKYGEPTPAALVESALRHVEHL 168
Cdd:TIGR00612  81 FAYSYAALAMAKGVAKVRINPGNIGFEERVRDIVEKARRHGKAMRIGVNHGSLERRLLEKYGDPTAEAMVQSALEWAEIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  169 ERLNFQDFKVSVKASDVFMAVEAYRLLAKEIVQPLHLGITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRISLAADPVEEV 248
Cdd:TIGR00612 161 EKLGFRNVVVSMKASDVLQTVAAYRLLAERSDYPLHLGVTEAGMGVKGIIKSSVGIGILLAMGIGDTIRVSLTDDPVVEV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  249 KVGYDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDLLVPLDVAVIGCVVNGPGEAKEAHIGLTGGTPNLI 328
Cdd:TIGR00612 241 PVAYEILQSLGLRRRGVEIVACPSCGRTGFDLEKVVKEVQEALSHLKTPLKVAVMGCVVNGPGEAKHADIGISGPGTGFA 320
                         330       340
                  ....*....|....*....|....*
gi 489277460  329 --YIDGKPSQKLTNDNLVDELERLI 351
Cdd:TIGR00612 321 wlFKHGKPKAKVPETDMVDELIKLI 345
PLN02925 PLN02925
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
9-248 1.65e-65

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase


Pssm-ID: 178513  Cd Length: 733  Bit Score: 220.78  E-value: 1.65e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   9 RRESRKIWVGNVPVGGDAPIAVQSMTNSDTNDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKIK-QLVK----VPL 83
Cdd:PLN02925  77 RRKTRTVMVGNVALGSEHPIRIQTMTTTDTKDVEATVDQVMRIADKGADIVRITVQGKKEADACFEIKnTLVQkgynIPL 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  84 VADIHFDYRIALRVAELgVDCLRINPGNI--GR---------EDRVRA-----------VVDAARDRGIPIRIGVNAGSL 141
Cdd:PLN02925 157 VADIHFAPSVALRVAEC-FDKIRVNPGNFadRRaqfekleytEDDYQKelehieevftpLVEKCKKYGRAMRIGTNHGSL 235
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 142 EKDLQKKYGEpTPAALVESALRHVEHLERLNFQDFKVSVKASDVFMAVEAYRLLAKEIVQ-----PLHLGITEAGGLRSG 216
Cdd:PLN02925 236 SDRIMSYYGD-SPRGMVESAFEFARICRKLDYHNFVFSMKASNPVVMVQAYRLLVAEMYVlgwdyPLHLGVTEAGEGEDG 314
                        250       260       270
                 ....*....|....*....|....*....|..
gi 489277460 217 TVKSAVGLGMLLAEGIGDTIRISLAADPVEEV 248
Cdd:PLN02925 315 RMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEI 346
PRK00694 PRK00694
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated
1-256 3.35e-62

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated


Pssm-ID: 234812  Cd Length: 606  Bit Score: 209.69  E-value: 3.35e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   1 MHGESPIK---RRESRKIWVGNVPVGGDAPIAVQSMTNSDTNDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKIK- 76
Cdd:PRK00694   1 MMATPCIQnafRRKTHPVRIGNLFVGSEHSIKIQSMTTTATTDVDGTVRQICALQEWGCDIVRVTVQGLKEAQACEHIKe 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  77 ----QLVKVPLVADIHFDYRIALRVAELgVDCLRINPGNI--------GR--------------EDRVRAVVDAARDRGI 130
Cdd:PRK00694  81 rliqQGISIPLVADIHFFPQAAMHVADF-VDKVRINPGNYvdkrnmftGKiytdeqyahsllrlEEKFSPLVEKCKRLGK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 131 PIRIGVNAGSLEKDLQKKYGEpTPAALVESALRHVEHLERLNFQDFKVSVKASDVFMAVEAYRLLAKEIVQ-----PLHL 205
Cdd:PRK00694 160 AMRIGVNHGSLSERVMQRYGD-TIEGMVYSALEYIEVCEKLDYRDVVFSMKSSNPKVMVAAYRQLAKDLDArgwlyPLHL 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489277460 206 GITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRISLAADPVEEVKVGYDILK 256
Cdd:PRK00694 239 GVTEAGSGTDGIIKSAVGIGTLLSEGLGDTIRCSLTGCPTNEIPVCISLLK 289
PRK02048 PRK02048
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional
8-279 1.23e-59

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional


Pssm-ID: 179361  Cd Length: 611  Bit Score: 202.76  E-value: 1.23e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460   8 KRRESRKIWVGNVPVGGDAPIAVQSMTNSDTNDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKI-KQLVK----VP 82
Cdd:PRK02048   7 SRRKTSVVNIGATPLGGPNPIRIQSMTNTSTMDTEACVAQAKRIIDAGGEYVRLTTQGVREAENLMNInIGLRSqgymVP 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  83 LVADIHFDYRIAlRVAELGVDCLRINPGNI---GR--------EDRVRAVVDAARDRGIP-----------IRIGVNAGS 140
Cdd:PRK02048  87 LVADVHFNPKVA-DVAAQYAEKVRINPGNYvdpGRtfkkleytDEEYAQEIQKIRDRFVPflnickenhtaIRIGVNHGS 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 141 LEKDLQKKYGEpTPAALVESALRHVEHLERLNFQDFKVSVKASDVFMAVEAYRLLAKEIVQ-----PLHLGITEAGGLRS 215
Cdd:PRK02048 166 LSDRIMSRYGD-TPEGMVESCMEFLRICVEEHFTDVVISIKASNTVVMVRTVRLLVAVMEAegmhyPLHLGVTEAGDGED 244
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489277460 216 GTVKSAVGLGMLLAEGIGDTIRISLAADPVEEVKVGYDILKSLHLRsRGINFIACPSCSRQNFD 279
Cdd:PRK02048 245 GRIKSAVGIGALLADGIGDTIRVSLSEEPEAEIPVARKLVDYIRSR-ENHPYIPGMEAPGFDYL 307
PLN02925 PLN02925
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
218-352 5.93e-12

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase


Pssm-ID: 178513  Cd Length: 733  Bit Score: 67.09  E-value: 5.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 218 VKSAVGLGMLLAEGIGDTIRISLAADPVEEVK-VGYDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRlEDLLV 296
Cdd:PLN02925 584 IQAGSQAGALLVDGLGDGVLLEAPDQDFDFLRnTSFGLLQGCRMRNTKTEYVSCPSCGRTLFDLQEVSAEIREK-TSHLP 662
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 297 PLDVAVIGCVVNGPGEAKEAHIGLTGGTPNLI--YIdGKPSQK--LTNDNLVDELERLIR 352
Cdd:PLN02925 663 GVSIAIMGCIVNGPGEMADADFGYVGGAPGKIdlYV-GKEVVKrgIAMEEATDALIQLIK 721
PRK02048 PRK02048
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional
218-328 1.75e-11

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional


Pssm-ID: 179361  Cd Length: 611  Bit Score: 65.62  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460 218 VKSAVGLGMLLAEGIGDTIRIsLAADPVEEVKV---GYDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDL 294
Cdd:PRK02048 467 LKAAADMGALIFDGLCDGIFL-FNQGKLSHVVVdatAFGILQAGRLRTSKTEYISCPGCGRTLYDLQSTIARIKEATSHL 545
                         90       100       110
                 ....*....|....*....|....*....|....
gi 489277460 295 lVPLDVAVIGCVVNGPGEAKEAHIGLTGGTPNLI 328
Cdd:PRK02048 546 -KGLKIGIMGCIVNGPGEMADADYGYVGAGRGKI 578
YcjR COG1082
Sugar phosphate isomerase/epimerase [Carbohydrate transport and metabolism];
27-178 2.13e-03

Sugar phosphate isomerase/epimerase [Carbohydrate transport and metabolism];


Pssm-ID: 440699 [Multi-domain]  Cd Length: 254  Bit Score: 39.23  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  27 PIAVQSMTNSDTnDVAATVAQINRLEAAGVDIVRVSVPDMDAAEAFGKIKQL-VKVPLV----ADIHFD----------Y 91
Cdd:COG1082    2 KLGLSTYSLPDL-DLEEALRAAAELGYDGVELAGGDLDEADLAELRAALADHgLEISSLhapgLNLAPDpevreaalerL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277460  92 RIALRVA-ELGVDCLRINPGNIGRE------------DRVRAVVDAARDRGipIRIGVnagslekdlqkkygEPTPAALV 158
Cdd:COG1082   81 KRAIDLAaELGAKVVVVHPGSPPPPdlppeeawdrlaERLRELAELAEEAG--VTLAL--------------ENHEGTFV 144
                        170       180
                 ....*....|....*....|
gi 489277460 159 ESALRHVEHLERLNFQDFKV 178
Cdd:COG1082  145 NTPEEALRLLEAVDSPNVGL 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH