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Conserved domains on  [gi|489277918|ref|WP_003185590|]
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MULTISPECIES: tetratricopeptide repeat protein [Bacillus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 1000094)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
93-298 5.50e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.10  E-value: 5.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  93 YYFKANNYAHLGLFQEAYKAAETYLKEDPDGEFSEENAELLDLLDMGEEDQGYSQFDQDDLILK-QDRAKSLLENGQLQE 171
Cdd:COG3914   17 LLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALlELAALLLQALGRYEE 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 172 SIAMLEEIISDYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEALSEQLSNIY 251
Cdd:COG3914   97 ALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 489277918 252 PMLFEQRYKLGATLALVGRYDLGFKWLKSLYRMGFEGDETFYYWLAC 298
Cdd:COG3914  177 PDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFA 223
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
19-124 4.01e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.15  E-value: 4.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  19 QDGQYFYHKGLKAYRERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFILKnINEKMTECYYFKAN 98
Cdd:COG4235   15 NDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALA-LDPDNPEALYLLGL 93
                         90       100
                 ....*....|....*....|....*.
gi 489277918  99 NYAHLGLFQEAYKAAETYLKEDPDGE 124
Cdd:COG4235   94 AAFQQGDYAEAIAAWQKLLALLPADA 119
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
93-298 5.50e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.10  E-value: 5.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  93 YYFKANNYAHLGLFQEAYKAAETYLKEDPDGEFSEENAELLDLLDMGEEDQGYSQFDQDDLILK-QDRAKSLLENGQLQE 171
Cdd:COG3914   17 LLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALlELAALLLQALGRYEE 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 172 SIAMLEEIISDYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEALSEQLSNIY 251
Cdd:COG3914   97 ALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 489277918 252 PMLFEQRYKLGATLALVGRYDLGFKWLKSLYRMGFEGDETFYYWLAC 298
Cdd:COG3914  177 PDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFA 223
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
19-124 4.01e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.15  E-value: 4.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  19 QDGQYFYHKGLKAYRERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFILKnINEKMTECYYFKAN 98
Cdd:COG4235   15 NDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALA-LDPDNPEALYLLGL 93
                         90       100
                 ....*....|....*....|....*.
gi 489277918  99 NYAHLGLFQEAYKAAETYLKEDPDGE 124
Cdd:COG4235   94 AAFQQGDYAEAIAAWQKLLALLPADA 119
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
33-325 1.48e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.30  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918   33 RERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLdfilkninEKMTECYYFKANNYAHLGLF------ 106
Cdd:TIGR02917 341 RLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYL--------AKATELDPENAAARTQLGISklsqgd 412
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  107 -QEAYKAAETYLKEDPDGEfseeNAELLdlldmgeedqgysqfdqddLILkqdrakSLLENGQLQESIAMLEEIISDYPE 185
Cdd:TIGR02917 413 pSEAIADLETAAQLDPELG----RADLL-------------------LIL------SYLRSGQFDKALAAAKKLEKKQPD 463
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  186 FWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEALSEQLSNIYPMLFEQRYKLGATL 265
Cdd:TIGR02917 464 NASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLY 543
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489277918  266 ALVGRYDLGFKWLKSLYRMGfEGDETFYywLACSAYYTGRVQFARS--VWKKMQEEYPDDAR 325
Cdd:TIGR02917 544 LRTGNEEEAVAWLEKAAELN-PQEIEPA--LALAQYYLGKGQLKKAlaILNEAADAAPDSPE 602
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
93-298 5.50e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.10  E-value: 5.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  93 YYFKANNYAHLGLFQEAYKAAETYLKEDPDGEFSEENAELLDLLDMGEEDQGYSQFDQDDLILK-QDRAKSLLENGQLQE 171
Cdd:COG3914   17 LLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALlELAALLLQALGRYEE 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 172 SIAMLEEIISDYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEALSEQLSNIY 251
Cdd:COG3914   97 ALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 489277918 252 PMLFEQRYKLGATLALVGRYDLGFKWLKSLYRMGFEGDETFYYWLAC 298
Cdd:COG3914  177 PDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFA 223
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
30-247 1.05e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.14  E-value: 1.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  30 KAYRER-NLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFILKnINEKMTECYYFKANNYAHLGLFQE 108
Cdd:COG2956   50 NLYRRRgEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLE-LDPDDAEALRLLAEIYEQEGDWEK 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 109 AYKAAETYLKEDPD-GEFSEENAELLdlLDMGEEDQGYSQFDQ------DDLILKQDRAKSLLENGQLQESIAMLEEIIS 181
Cdd:COG2956  129 AIEVLERLLKLGPEnAHAYCELAELY--LEQGDYDEAIEALEKalkldpDCARALLLLAELYLEQGDYEEAIAALERALE 206
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489277918 182 DYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEALSEQL 247
Cdd:COG2956  207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQL 272
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
17-283 1.34e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.14  E-value: 1.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  17 LFQDGQYFyhKGLKAYRERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFILKnINEKMTECYYFK 96
Cdd:COG2956    6 AAALGWYF--KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLE-RDPDRAEALLEL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  97 ANNYAHLGLFQEAYKAAETYLKEDPDgefseeNAELLDLLdmgeedqgysqfdqddlilkqdrAKSLLENGQLQESIAML 176
Cdd:COG2956   83 AQDYLKAGLLDRAEELLEKLLELDPD------DAEALRLL-----------------------AEIYEQEGDWEKAIEVL 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 177 EEIISDYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEALSEQLSNIYPMLFE 256
Cdd:COG2956  134 ERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLP 213
                        250       260
                 ....*....|....*....|....*..
gi 489277918 257 QRYKLGATLALVGRYDLGFKWLKSLYR 283
Cdd:COG2956  214 ALPRLAELYEKLGDPEEALELLRKALE 240
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
159-382 2.89e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.82  E-value: 2.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 159 RAKSLLENGQLQESIAMLEEIISDYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDD 238
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 239 KVEALSEQLSNIYPMLFEQRYKLGATLALVGRYDLGFKWLKSLYRMGfEGDETFYYWLACSAYYTGRVQFARSVWKKMQE 318
Cdd:COG2956   94 RAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLG-PENAHAYCELAELYLEQGDYDEAIEALEKALK 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 319 EYPDDAR------------------MEPWKERKEKRPVQRPLEERLAAYYIsgRKGEKAQLKAVLDSQMAKTPFEDQFVR 380
Cdd:COG2956  173 LDPDCARallllaelyleqgdyeeaIAALERALEQDPDYLPALPRLAELYE--KLGDPEEALELLRKALELDPSDDLLLA 250

                 ..
gi 489277918 381 LV 382
Cdd:COG2956  251 LA 252
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
20-263 6.17e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.55  E-value: 6.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  20 DGQYFYHKGLKAYRERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFILKnINEKMTECYYFKANN 99
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE-LDPDDAEALNNLGLA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 100 YAHLGLFQEAYKAAETYLKEDPDgefseeNAELLDlldmgeedqgysqfdqddlilkqDRAKSLLENGQLQESIAMLEEI 179
Cdd:COG0457   86 LQALGRYEEALEDYDKALELDPD------DAEALY-----------------------NLGLALLELGRYDEAIEAYERA 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 180 ISDYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEALSEQLSNIYPMLFEQRY 259
Cdd:COG0457  137 LELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTL 216

                 ....
gi 489277918 260 KLGA 263
Cdd:COG0457  217 AALA 220
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
157-284 9.30e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.96  E-value: 9.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 157 QDRAKSLLENGQLQESIAMLEEIISDYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERR 236
Cdd:COG4783    8 YALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGD 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489277918 237 DDKVEALSEQLSNIYPMLFEQRYKLGATLALVGRYDLGFKWLKSLYRM 284
Cdd:COG4783   88 YDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
85-283 5.20e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 5.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  85 INEKMTECYYFKANNYAHLGLFQEAYKAAETYLKEDPDgefseeNAELLDLLdmgeedqgysqfdqddlilkqdrAKSLL 164
Cdd:COG0457    3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPD------DAEALYNL-----------------------GLAYL 53
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 165 ENGQLQESIAMLEEIISDYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEALS 244
Cdd:COG0457   54 RLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAY 133
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 489277918 245 EQLSNIYPMLFEQRYKLGATLALVGRYDLGFKWLKSLYR 283
Cdd:COG0457  134 ERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEA 172
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
19-206 1.65e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.23  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  19 QDGQYFYHKGLKAYRERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFILKnINEKMTECYYFKAN 98
Cdd:COG0457   40 DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALE-LDPDDAEALYNLGL 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  99 NYAHLGLFQEAYKAAETYLKEDPDGEFSEENAELLdLLDMGEEDQGYSQFDQDDLILKQDRAKSLLENGQLQESIAMLEE 178
Cdd:COG0457  119 ALLELGRYDEAIEAYERALELDPDDADALYNLGIA-LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLL 197
                        170       180
                 ....*....|....*....|....*...
gi 489277918 179 IISDYPEFWSAYNNLALAYFYAGDVQKA 206
Cdd:COG0457  198 ALLLALEQALRKKLAILTLAALAELLLL 225
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
100-253 1.91e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 47.65  E-value: 1.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 100 YAHLGLFQEAYKAAETYLKEDPDGEFSEENAELLDLLDMGEEDQGYSQFDQDDLILKQDRAKSLLENGQLQESIAMLEEI 179
Cdd:COG5010    1 ARALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQA 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489277918 180 ISDYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEALSEQLSNIYPM 253
Cdd:COG5010   81 LQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSPL 154
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
19-124 4.01e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.15  E-value: 4.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  19 QDGQYFYHKGLKAYRERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFILKnINEKMTECYYFKAN 98
Cdd:COG4235   15 NDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALA-LDPDNPEALYLLGL 93
                         90       100
                 ....*....|....*....|....*.
gi 489277918  99 NYAHLGLFQEAYKAAETYLKEDPDGE 124
Cdd:COG4235   94 AAFQQGDYAEAIAAWQKLLALLPADA 119
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
19-185 1.38e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.54  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  19 QDGQYFYHKGLKAYRERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFILKnINEKMTECYYFKAN 98
Cdd:COG0457   74 DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALE-LDPDDADALYNLGI 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  99 NYAHLGLFQEAYKAAETYLKEDPDGEFSEENAELLDLLDMGEEDQGYSQFDQDDLILKQDRAKSLLENGQLQESIAMLEE 178
Cdd:COG0457  153 ALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLA 232

                 ....*..
gi 489277918 179 IISDYPE 185
Cdd:COG0457  233 LRLAALA 239
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
19-122 5.38e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.26  E-value: 5.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  19 QDGQYFYHKGLKAYRERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFILKnINEKMTECYYFKAN 98
Cdd:COG4783   36 DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALK-LDPEHPEAYLRLAR 114
                         90       100
                 ....*....|....*....|....
gi 489277918  99 NYAHLGLFQEAYKAAETYLKEDPD 122
Cdd:COG4783  115 AYRALGRPDEAIAALEKALELDPD 138
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
33-325 1.48e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.30  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918   33 RERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLdfilkninEKMTECYYFKANNYAHLGLF------ 106
Cdd:TIGR02917 341 RLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYL--------AKATELDPENAAARTQLGISklsqgd 412
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  107 -QEAYKAAETYLKEDPDGEfseeNAELLdlldmgeedqgysqfdqddLILkqdrakSLLENGQLQESIAMLEEIISDYPE 185
Cdd:TIGR02917 413 pSEAIADLETAAQLDPELG----RADLL-------------------LIL------SYLRSGQFDKALAAAKKLEKKQPD 463
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  186 FWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEALSEQLSNIYPMLFEQRYKLGATL 265
Cdd:TIGR02917 464 NASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLY 543
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489277918  266 ALVGRYDLGFKWLKSLYRMGfEGDETFYywLACSAYYTGRVQFARS--VWKKMQEEYPDDAR 325
Cdd:TIGR02917 544 LRTGNEEEAVAWLEKAAELN-PQEIEPA--LALAQYYLGKGQLKKAlaILNEAADAAPDSPE 602
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
180-324 1.82e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 180 ISDYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEALSEQLSNIYPMLFEQRY 259
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489277918 260 KLGATLALVGRYDLGFKWLKSLYRMGFEgDETFYYWLACSAYYTGRVQFARSVWKKMQEEYPDDA 324
Cdd:COG0457   81 NLGLALQALGRYEEALEDYDKALELDPD-DAEALYNLGLALLELGRYDEAIEAYERALELDPDDA 144
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
93-252 4.34e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 4.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  93 YYFKANNYAHLGLFQEAYKAAETYLKEDPDgefseeNAELLDLLdmgeedqgysqfdqddlilkqdrAKSLLENGQLQES 172
Cdd:COG4783    7 LYALAQALLLAGDYDEAEALLEKALELDPD------NPEAFALL-----------------------GEILLQLGDLDEA 57
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 173 IAMLEEIISDYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEALSEQLSNIYP 252
Cdd:COG4783   58 IVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
116-248 6.09e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.44  E-value: 6.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 116 YLKEDPDGEFSEENAELLDLLDMgEEDQGYSQFDQDDLILKQDRAKSLLENGQLQESIAMLEEIISDYPEFWSAYNNLAL 195
Cdd:COG4785   37 LAIALADLALALAAAALAAAALA-AERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGL 115
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489277918 196 AYFYAGDVQKAKTTVFTVLEKSHGNLHALCNL-LIFYHYERRDDKVEALSEQLS 248
Cdd:COG4785  116 AYLLLGDYDAALEDFDRALELDPDYAYAYLNRgIALYYLGRYELAIADLEKALE 169
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
35-310 9.48e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 9.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918   35 RNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDfILKNINEKMTECYYFKANNYAHlglfQEAYKAAE 114
Cdd:TIGR02917 649 KNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAK-SLQKQHPKAALGFELEGDLYLR----QKDYPAAI 723
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  115 TYLKEdpdgefseenaelldlldmgeedqGYSQFDQDDLILKQDRAksLLENGQLQESIAMLEEIISDYPEFWSAYNNLA 194
Cdd:TIGR02917 724 QAYRK------------------------ALKRAPSSQNAIKLHRA--LLASGNTAEAVKTLEAWLKTHPNDAVLRTALA 777
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  195 LAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHyERRDDKVEALSE----QLSNIYPMLfeqrYKLGATLALVGR 270
Cdd:TIGR02917 778 ELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYL-ELKDPRALEYAEralkLAPNIPAIL----DTLGWLLVEKGE 852
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 489277918  271 YDLGFKWL-KSLYRMgfEGDETFYYWLACSAYYTGRVQFAR 310
Cdd:TIGR02917 853 ADRALPLLrKAVNIA--PEAAAIRYHLALALLATGRKAEAR 891
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
28-122 1.03e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.52  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  28 GLKAYRERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFILKnINEKMTECYYFKANNYAHLGLFQ 107
Cdd:COG3914  119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALE-LDPDNAEALNNLGNALQDLGRLE 197
                         90
                 ....*....|....*
gi 489277918 108 EAYKAAETYLKEDPD 122
Cdd:COG3914  198 EAIAAYRRALELDPD 212
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
19-122 1.16e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.40  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  19 QDGQYFYHKGLKAYRERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFILKnINEKMTECYYFKAN 98
Cdd:COG4783    2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALE-LDPDEPEARLNLGL 80
                         90       100
                 ....*....|....*....|....
gi 489277918  99 NYAHLGLFQEAYKAAETYLKEDPD 122
Cdd:COG4783   81 ALLKAGDYDEALALLEKALKLDPE 104
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
160-252 1.17e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 160 AKSLLENGQLQESIAMLEEIISDYPEFWSAYNNLALAYFYAGDVQKAKTTVFTVLEKSHGNLHALCNLLIFYHYERRDDK 239
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAE 103
                         90
                 ....*....|...
gi 489277918 240 VEALSEQLSNIYP 252
Cdd:COG4235  104 AIAAWQKLLALLP 116
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
163-256 2.18e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918 163 LLENGQLQESIAMLEEIISDYPEFWSAYNNLALAYFYAGDVQKAKtTVFTVLEKSHGNLHALCNLLIFYHYERRDDKVEA 242
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALA 80
                         90
                 ....*....|....
gi 489277918 243 LSEQLSNIYPMLFE 256
Cdd:COG3063   81 YLERALELDPSALR 94
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
31-122 3.49e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 3.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  31 AYRERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFIlkNINEKMTECYYFKANNYAHLGLFQEAY 110
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALEKAL--KLDPNNAEALLNLAELLLELGDYDEAL 79
                         90
                 ....*....|..
gi 489277918 111 KAAETYLKEDPD 122
Cdd:COG3063   80 AYLERALELDPS 91
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
31-150 7.43e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 37.97  E-value: 7.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489277918  31 AYRERNLSRASKLIQRAIFLEPENTGMLSQLAVIYTEMGFYQQSNELLDFILKnINEKMTECYYFKANNYAHLGLFQEAY 110
Cdd:COG4785   49 AAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE-LDPDLAEAYNNRGLAYLLLGDYDAAL 127
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 489277918 111 KAAETYLKEDPDGEFSEENAELLdLLDMGEEDQGYSQFDQ 150
Cdd:COG4785  128 EDFDRALELDPDYAYAYLNRGIA-LYYLGRYELAIADLEK 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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