|
Name |
Accession |
Description |
Interval |
E-value |
| ASKHA_NBD_ROK_BsFRK-like |
cd24067 |
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ... |
4-281 |
2.67e-149 |
|
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466917 [Multi-domain] Cd Length: 285 Bit Score: 419.26 E-value: 2.67e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 4 YGAIEAGGTKFCCAIGNEHGDILEEMTIPTEHPEKTLQKLIPFFEQHD--IEALGVGSFGPICVQKDDPSYGYIMNTPKV 81
Cdd:cd24067 1 FGGIEAGGTKFVCAVGTGDGNIIERTEFPTTTPEETLQAVIDFFREQEepIDAIGIASFGPIDLNPTSPTYGYITTTPKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 82 EWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHSHPEMGHILVRQH 161
Cdd:cd24067 81 GWRNFDILGALKRAFPVPVGFDTDVNAAALAEYRWGAAKGLDSLAYITVGTGIGVGLVVNGKPVHGLLHPEMGHIRVPRH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 162 ESDV-FEGVCPAHGTCLEGLAAGPAIEKRWGKSAKELTEEKSVWALEADYLAQALMQYSLILSPERIIMGGGVMKQKQLF 240
Cdd:cd24067 161 PDDDgFPGVCPFHGDCLEGLASGPAIAARWGIPAEELPDDHPAWDLEAYYLAQACANLTLTLSPERIVLGGGVMQRPGLF 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 489306294 241 PLIREKLVAYLNDYVDLP----PLDTYIVSPGLEDKAGMTGALLL 281
Cdd:cd24067 241 PRIREKFRKLLNGYLEVPrllpDIDEYIVPPALGNDAGILGALAL 285
|
|
| ROK |
pfam00480 |
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
5-284 |
1.44e-75 |
|
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.
Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 232.62 E-value: 1.44e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 5 GAIEAGGTKFCCAIGNEHGDIL--EEMTIPTEHPEKTLQKLIPFF----EQ--HDIEALGVGSFGPIcvqkdDPSYGYIM 76
Cdd:pfam00480 1 IGIDIGGTKIAAALFDEEGEILarERVPTPTTTTEETLVDAIAFFvdsaQRkfGELIAVGIGSPGLI-----SPKYGYIT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 77 NTPKVEWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHS--HPEMG 154
Cdd:pfam00480 76 NTPNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNgvAGEIG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 155 HILVrqhESDVFEGVCPAHGtCLEGLAAGPAIEKRWGKSAKELT-------EEKS------VWALEADYLAQALMQYSLI 221
Cdd:pfam00480 156 HIQL---DPNGPKCGCGNHG-CLETIASGRALEKRYQQKGEDLEgkdiivlAEQGdevaeeAVERLARYLAKAIANLINL 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489306294 222 LSPERIIMGGGVMKQKQLFPLIREKLVAYLNDYVDLPPLDtyIVSPGLEDKAGMTGALLLAIE 284
Cdd:pfam00480 232 FDPQAIVLGGGVSNADGLLEAIRSLVKKYLNGYLPVPPVI--IVAASLGDNAGALGAAALAKQ 292
|
|
| NagC |
COG1940 |
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
1-284 |
2.79e-72 |
|
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];
Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 224.39 E-value: 2.79e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 1 MAYYGAIEAGGTKFCCAIGNEHGDILEEMTIPTEH---PEKTLQKLIPFFEQ---------HDIEALGVGSFGPIcvqkd 68
Cdd:COG1940 4 AGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAgagPEAVLEAIAELIEEllaeagisrGRILGIGIGVPGPV----- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 69 DPSYGYIMNTPKVE-WKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHG 147
Cdd:COG1940 79 DPETGVVLNAPNLPgWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 148 HS--HPEMGHILVRQHESDVFegvCPAHGtCLEGLAAGPAIEKRWGK-------SAKELTEE--------KSVWALEADY 210
Cdd:COG1940 159 ANgnAGEIGHMPVDPDGPLCG---CGNRG-CLETYASGPALLRRARElggaeklTAEELFAAaragdplaLEVLDEAARY 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489306294 211 LAQALMQYSLILSPERIIMGGGVMKQ-KQLFPLIREKLVAYLndyvdLPPL--DTYIVSPGLEDKAGMTGALLLAIE 284
Cdd:COG1940 235 LGIGLANLINLLDPEVIVLGGGVSAAgDLLLEPIREALAKYA-----LPPAreDPRIVPASLGDDAGLLGAAALALE 306
|
|
| ASKHA_ATPase_ROK |
cd23763 |
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ... |
6-281 |
1.08e-45 |
|
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.
Pssm-ID: 466849 [Multi-domain] Cd Length: 239 Bit Score: 154.16 E-value: 1.08e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 6 AIEAGGTKFCCAIGNEHGDILEEMTIPTEH---PEKTLQKLIPFFEQ--------HDIEALGVGSFGPIcvqkdDPSYGY 74
Cdd:cd23763 2 GIDIGGTKIRAALVDLDGEILARERVPTPAeegPEAVLDRIAELIEEllaeagvrERILGIGIGVPGPV-----DPETGI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 75 IMNTPKV-EWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHS--HP 151
Cdd:cd23763 77 VLFAPNLpWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANgaAG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 152 EMGHIlvrqhesdvfegvcpahgtcleglaagpaiekrwgksakelteekSVWALEADYLAQALMQYSLILSPERIIMGG 231
Cdd:cd23763 157 EIGHI---------------------------------------------TVLEEAARYLGIGLANLINLLNPELIVLGG 191
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 489306294 232 GVMKQKQLF-PLIREKLVAYLNDYvdlPPLDTYIVSPGLEDKAGMTGALLL 281
Cdd:cd23763 192 GVAEAGDLLlEPIREAVRRRALPP---LRRRVRIVPSELGDDAGLLGAAAL 239
|
|
| ASKHA_NBD_ROK_FnNanK-like |
cd24068 |
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ... |
3-281 |
1.19e-43 |
|
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466918 [Multi-domain] Cd Length: 294 Bit Score: 150.40 E-value: 1.19e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 3 YYGAIEAGGTKFCCAIGNEHGDILEEMTIPTEH-------PEKTLQKLIPFFEQHDIEALGVGSFGPIcvqkdDPSYGYI 75
Cdd:cd24068 1 KILGIDIGGTKIKYGLVDADGEILEKDSVPTPAskggdaiLERLLEIIAELKEKYDIEGIGISSAGQV-----DPKTGEV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 76 M----NTPkvEWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHSHP 151
Cdd:cd24068 76 IyatdNLP--GWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 152 --EMGHILVrqhESDVFEGVCPAHGtCLEGLAAGPAIEKR-------WGKSAKE---LTEEKSVWALEA-----DYLAQA 214
Cdd:cd24068 154 agELGHMVV---DPGGRPCCCGGKG-CLEQYASGTALVRRvaealgePGIDGREifdLADAGDPLAKEVveefaEDLATG 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 215 LMQYSLILSPERIIMGGGVMKQKQLF-PLIREKLVAYLndyvdLPPL--DTYIVSPGLEDKAGMTGALLL 281
Cdd:cd24068 230 LANLVHIFDPEVIVIGGGISAQGELFlEELREELRKLL-----MPPLldATKIEPAKLGNDAGLLGAAYL 294
|
|
| ASKHA_NBD_ROK_SgGLK-like |
cd24061 |
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ... |
7-282 |
1.10e-34 |
|
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466911 [Multi-domain] Cd Length: 306 Bit Score: 127.08 E-value: 1.10e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 7 IEAGGTKFCCAIGNEHGDILEEMTIPTEHPEKTLQKLI-----PFFEQHDIEALGVGSFGPIcvqkdDPSYGYIMNTPKV 81
Cdd:cd24061 4 VDIGGTKIAAGVVDEEGEILATERVPTPPTADGIVDAIveaveELREGHDVSAVGVAAAGFV-----DADRATVLFAPNI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 82 EWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGH--SHPEMGHILVr 159
Cdd:cd24061 79 AWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAfgIAGEFGHIRV- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 160 qhesdVFEGV---CPAHGtCLEGLAAGPAIEkRWGKSAKELTEEKSVWALE----------------------------- 207
Cdd:cd24061 158 -----VPDGLlcgCGSRG-CWEQYASGRALV-RYAKEAANATPEGAAVLLAdgsvdgitgkhiseaaragdpvaldalre 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489306294 208 -ADYLAQALMQYSLILSPERIIMGGGVMKQKQLF-PLIREKLVAYLNDYVDLPPLDtyIVSPGLEDKAGMTGALLLA 282
Cdd:cd24061 231 lARWLGAGLASLAALLDPELFVIGGGVSDAGDLLlDPIREAFERWLPGRGWRPIPR--LRTAQLGNDAGLIGAADLA 305
|
|
| ASKHA_NBD_ROK_TmGLK-like |
cd24064 |
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ... |
7-278 |
4.73e-34 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466914 [Multi-domain] Cd Length: 301 Bit Score: 125.69 E-value: 4.73e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 7 IEAGGTKFCCAIGNEHGDILEEMTIPTEHPE----------KTLQKLIpffEQHDIEALGVGSFGPIcvqkdDPSYGYIM 76
Cdd:cd24064 4 IDLGGTDTKIGIVDENGDILKKKTIDTKVENgkedvinriaETVNELI---EEMELLGIGIGSPGSI-----DRENGIVR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 77 NTPKV-EWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHS--HPEM 153
Cdd:cd24064 76 FSPNFpDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDgiAAEL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 154 GHILVrqhESDVFEGVCPAHGtCLEGLAAGPAIEK---RWGK-------------SAKEL---TEEKSVWALE-----AD 209
Cdd:cd24064 156 GHVIV---EPNGPICGCGNRG-CVEAFASATAIIRyarESRKrypdslagesekiNAKHVfdaARKNDPLATMvfrrvVD 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489306294 210 YLAQALMQYSLILSPERIIMGGGVMKQKQ-LFPLIREKLVaylnDYVDLPPLDTY-IVSPGLEDKAGMTGA 278
Cdd:cd24064 232 ALAIAIGGFVHIFNPEIIIIGGGISRAGSfLLDPIREKTK----KYVMLSFQDTYsIELSNLVEDAGILGA 298
|
|
| ASKHA_NBD_ROK_ApGLK-like |
cd24063 |
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ... |
3-281 |
6.66e-33 |
|
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466913 [Multi-domain] Cd Length: 308 Bit Score: 122.45 E-value: 6.66e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 3 YYGAIEAGGTKFCCAIGNEHGDILEEMTIPTEHPEKTLQ------KLIPFF----EQHDIEALGVGSFGPIcvqkdDPSY 72
Cdd:cd24063 1 YYVAVDIGGTWIRAGLVDEDGRILLKIRQPTPKTGDPGTvseqvlGLIETLlskaGKDSIEGIGVSSAGPL-----DLRK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 73 GYIMNTPKVEWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELL---HGHS 149
Cdd:cd24063 76 GTIVNSPNIKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLlgkNGNA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 150 HpEMGHILVRQHEsdvfEGVCPAHGT-CLEGLAAGPAIEKRwgksAKELTEEKSVWALEA-------------------- 208
Cdd:cd24063 156 A-EVGHLVVDTES----GLKCGCGGYgHWEAFASGRGIPRF----AREWAEGFSSRTSLKlrnpggegitakevfsaark 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 209 -DYLAQALMQY---------SLILS---PERIIMGGGVMKQKQLF--PLIREklvaylndYVDLPPLDT--YIVSPGLED 271
Cdd:cd24063 227 gDPLALKIIEKlaryngrgiANVINaydPELIVIGGSVFNNNKDIldPLIEY--------LEKNPAISKgpEIVLSELGD 298
|
330
....*....|
gi 489306294 272 KAGMTGALLL 281
Cdd:cd24063 299 DVGLIGALAL 308
|
|
| ASKHA_NBD_ROK_BsGLK-like |
cd24062 |
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ... |
3-278 |
1.50e-31 |
|
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466912 [Multi-domain] Cd Length: 311 Bit Score: 118.93 E-value: 1.50e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 3 YYGAIEAGGTKFCCAIGNEHGDILEEMTIPT--------------EHPEKTLQKLIPffEQHDIEALGVGSFGPIcvqkd 68
Cdd:cd24062 1 WIVGIDVGGTTIKMAFLTQEGEIVQKWEIPTnkleggeniitdiaESIQQLLEELGY--SKEDLIGIGVGVPGPV----- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 69 DPSYGYIMNTPKVEWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGH 148
Cdd:cd24062 74 DVETGTVEVAVNLGWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 149 SHP--EMGHILVrqhesDVFEGV---CPAHGtCLEGLAAGPAI-----------------------EKRWGKSAKELTEE 200
Cdd:cd24062 154 NGAagEIGHITV-----NPEGGApcnCGKTG-CLETVASATGIvriareeleegkgssalrilalgGELTAKDVFEAAKA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 201 KSVWALE-----ADYLAQALMQYSLILSPERIIMGGGVMKQKQlfpLIREKLVAYLNDYVdLPPL--DTYIVSPGLEDKA 273
Cdd:cd24062 228 GDELALAvvdtvARYLGLALANLANTLNPEKIVIGGGVSAAGE---FLLSPVKEYFDRFT-FPRVrqDTEIVLATLGNDA 303
|
....*
gi 489306294 274 GMTGA 278
Cdd:cd24062 304 GVIGA 308
|
|
| ROK_glcA_fam |
TIGR00744 |
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ... |
6-282 |
2.29e-31 |
|
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]
Pssm-ID: 273246 [Multi-domain] Cd Length: 318 Bit Score: 118.85 E-value: 2.29e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 6 AIEAGGTKFCCAIGNEHGDILEEMTIPTEHPEKT----LQKLIPFFEQ------HDIEALGVGSFGPICVQKddpsyGYI 75
Cdd:TIGR00744 2 GVDIGGTTIKLGVVDEEGNILSKWKVPTDTTPETivdaIASAVDSFIQhiakvgHEIVAIGIGAPGPVNRQR-----GTV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 76 MNTPKVEWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGH--SHPEM 153
Cdd:TIGR00744 77 YFAVNLDWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHngVGAEI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 154 GHIlvRQHESDVFEGVCPAHGtCLEGLAAGPAIEKRWGKSAKELTEEKSVWALEAD------------------------ 209
Cdd:TIGR00744 157 GHI--RMVPDGRLLCNCGKQG-CIETYASATGLVRYAKRANAKPERAEVLLALGDGdgisakhvfvaarqgdpvavdsyr 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489306294 210 ----YLAQALMQYSLILSPERIIMGGGVMKQKQlfpLIREKL-VAYLNDYVDLPPLDTYIVSPGLEDKAGMTGALLLA 282
Cdd:TIGR00744 234 evarWAGAGLADLASLFNPSAIVLGGGLSDAGD---LLLDPIrKSYKRWLFGGARQVADIIAAQLGNDAGLVGAADLA 308
|
|
| ASKHA_ATPase_ROK_BsXylR-like |
cd24076 |
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ... |
23-284 |
4.24e-28 |
|
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.
Pssm-ID: 466926 [Multi-domain] Cd Length: 303 Bit Score: 109.58 E-value: 4.24e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 23 GDILEEMTIPTEH---PEKTLQKLIPFFEQ---------HDIEALGVGSFGPIcvqkdDPSYGYIMNTPKVEWKHYPFIP 90
Cdd:cd24076 22 GEVLWRREVPLPAsddPDEVLAQLAALIREalaaapdspLGILGIGVGVPGLV-----DSEDGVVLLAPNLGWRDVPLRD 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 91 ELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHS--HPEMGHILVRQHesdvfeG 168
Cdd:cd24076 97 LLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASgfAGEIGHMTVDPD------G 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 169 ---VCPAHGtCLEGLAAGPAIEKRWGKSAKELTEEK-----------SVWALEA-----DYLAQALMQYSLILSPERIIM 229
Cdd:cd24076 171 ppcSCGNRG-CWETYASERALLRAAGRLGAGGEPLSlaelveaaragDPAALAAleevgEYLGIGLANLVNTFNPELVVL 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 489306294 230 GGGVMkqkQLFPLIREKLVAYLNDYVdLPPL--DTYIVSPGLEDKAGMTGALLLAIE 284
Cdd:cd24076 250 GGALA---PLGPWLLPPLRAEVARRA-LPAParDVRIVVSRLGEDAAALGAAALAID 302
|
|
| ASKHA_NBD_ROK-like |
cd24152 |
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ... |
3-281 |
1.54e-26 |
|
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466988 [Multi-domain] Cd Length: 286 Bit Score: 104.96 E-value: 1.54e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 3 YYGAIEAGGTKFCCAIGNEHGDILEEMTIPT-----EHPEKTLQKLIPFFeQHDIEALGVGSFGPIcvqkdDPSYGYIMN 77
Cdd:cd24152 1 KYLVFDIGGTFIKYALVDENGNIIKKGKIPTpkdslEEFLDYIKKIIKRY-DEEIDGIAISAPGVI-----DPETGIIYG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 78 TPKVEW-KHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHSH--PEMG 154
Cdd:cd24152 75 GGALPYlKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFfaGEFS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 155 HILvrqHESDVFEGVCPAHGTCLEGLAAGPAIEKRW----GKSAKELTEEKSVWALEA-----DYLAQALMQYSLILSPE 225
Cdd:cd24152 155 YLL---TDDDDKDLLFFSGLASMFGLVKRYNKAKGLepldGEEIFEKYAKGDEAAKKIldeyiRNLAKLIYNIQYILDPE 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 489306294 226 RIIMGGGVMKQKQLFPLIREKLVAYL-NDYVDLPPldTYIVSPGLEDKAGMTGALLL 281
Cdd:cd24152 232 VIVIGGGISEQPLFIEDLKKEVNEILaNRPGSIPK--PEIKACKFGNDANLLGALYN 286
|
|
| ASKHA_ATPase_ROK_Lmo0178-like |
cd24071 |
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ... |
7-283 |
3.16e-26 |
|
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466921 [Multi-domain] Cd Length: 312 Bit Score: 104.67 E-value: 3.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 7 IEAGGTKFCCAigNEHGDILEEMTIPTEH---PEKTLQ----KLIPFFEQHDIEA----LGVGSFGPICVQKDDPSYGYI 75
Cdd:cd24071 8 IEEGYLVLALT--DLKGKILEKTRIPFDHetdPEKVIEliaeNIKKLIKNKHVEKkllgIGIAVSGLVDSKKGIVIRSTI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 76 MNtpkveWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGH--SHPEM 153
Cdd:cd24071 86 LG-----WENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNfgGAGEI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 154 GHILVRQhesDVFEGVCPAHGtCLEGLAAGPAIEKRwGKSAKELTEEKSVWALE-------------------------A 208
Cdd:cd24071 161 GHMTIQP---DGRKCYCGQKG-CLEAYASFEALVNE-IKELTESYPLSLLKELEdfeiekvreaaeegdsvatelfkkaG 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489306294 209 DYLAQALMQYSLILSPERIIMGGGVMKQKQLFpliREKLVAYLND-YVDLPPLDTYIVSPGLEDKAGMTGALLLAI 283
Cdd:cd24071 236 EYLGIGIKNLINIFNPEAIIIGGEGLEFKDYF---LPKIIEIAKEnFFGKAGRNVIILVDSLGEDAWVLGAALLVI 308
|
|
| ASKHA_NBD_ROK_TtHK-like |
cd24065 |
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ... |
7-281 |
7.84e-26 |
|
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466915 [Multi-domain] Cd Length: 289 Bit Score: 103.18 E-value: 7.84e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 7 IEAGGTKFCCAIGNEhGDILEEMTIPT--EHPEKTLQKLIPFFEQHD-----IEALGVGSFGPIcvqkdDPSYGYIMNTP 79
Cdd:cd24065 5 LDLGGTKIAAGVVDG-GRILSRLVVPTprEGGEAVLDALARAVEALQaeapgVEAVGLGVPGPL-----DFRRGRVRFAP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 80 KV-EWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHsH---PEMGH 155
Cdd:cd24065 79 NIpGLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGR-HgqaGEIGH 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 156 ILVRQHesdvfeGVCPAHGT--CLEGLAAGPAIEKR----WGK--SAKEL------TEEKSVWALE--ADYLAQALMQYS 219
Cdd:cd24065 158 TTVLPG------GPMCGCGLvgCLEALASGRALARDasfaYGRpmSTAELfelaqqGEPKALRIVEqaAAHLGIGLANLQ 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489306294 220 LILSPERIIMGGGVMKQ-KQLFPLIREKLVAYLNDYVDLPpldtyIVSPGLEDKAGMTGALLL 281
Cdd:cd24065 232 KALDPEVFVLGGGVAQVgDYYLLPVQEAARRYTEGWHAPP-----LRLAHLGTDAGVIGAALA 289
|
|
| ASKHA_NBD_ROK_TM1224-like |
cd24059 |
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ... |
23-284 |
4.94e-23 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466909 [Multi-domain] Cd Length: 305 Bit Score: 96.12 E-value: 4.94e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 23 GDILEEMTIPTEH---PEKTLQKLIP----FFEQHDIE----ALGVGSFGPIcvqkdDPSYGYIMNTPKV-EWKHYPFIP 90
Cdd:cd24059 22 GNILAREKYPLDEkenPEEVLEKLYElidrLLEKENIKskilGIGIGAPGPL-----DVEKGIILNPPNFpGWENIPLVE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 91 ELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHG-HSHP-EMGHILVrqhesdVFEG 168
Cdd:cd24059 97 LLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGvDGYAgEIGHTSI------DING 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 169 V---CPAHGtCLEGLAAGPAIEKR----------WGKSAKELTEEKSVWALE-----ADYLAQALMQYSLILSPERIIMG 230
Cdd:cd24059 171 PrcsCGNRG-CLELYASIPAIEKKarsalgsgrsFQLDIVEALQKGDPIADEvieeaAKYLGIGLVNLINLLNPEAIIIG 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 489306294 231 GGVMKqkqlfplIREKLVAYLNDYVD--LPPLDTY---IVSPGLEDKAGMTGALLLAIE 284
Cdd:cd24059 250 GELIY-------LGERYLEPIEKEVNsrLFGRNARevrILKSSLGEDAPLLGAAALVLN 301
|
|
| ASKHA_NBD_ROK_EcFRK-like |
cd24066 |
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ... |
7-281 |
3.81e-21 |
|
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466916 [Multi-domain] Cd Length: 294 Bit Score: 90.73 E-value: 3.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 7 IEAGGTKFCCAIGNEHGDILEEMTIPTEHP--EKTL---QKLIPFFEQ--HDIEALGVGSFGPIcvqkdDPSYGYIMNTP 79
Cdd:cd24066 4 IDLGGTKIEGIALDRAGRELLRRRVPTPRGdyEATLdaiADLVEEAEEelGAPATVGIGTPGSI-----SPRTGLVKNAN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 80 KVEWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHSH--PEMGHIL 157
Cdd:cd24066 79 STWLNGKPLKADLEARLGRPVRIENDANCFALSEATDGAGAGAGVVFGVILGTGVGGGIVVNGRVLTGANGiaGEWGHNP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 158 VRQHESDVFEGV---CPAHGtCLEGLAAGPAIEKRW----GK--SAKELTEE--------KSVWALEADYLAQALMQYSL 220
Cdd:cd24066 159 LPWPDEDELPGPpcyCGKRG-CVETFLSGPALERDYarltGKtlSAEEIVALaragdaaaVATLDRFLDRLGRALANVIN 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489306294 221 ILSPERIIMGGGVMKQKQLFplirEKLVAYLNDYVDLPPLDTYIVSPGLEDKAGMTGALLL 281
Cdd:cd24066 238 ILDPDVIVLGGGLSNIDELY----TEGPAALARYVFSDEVETPIVKNKHGDSSGVRGAAWL 294
|
|
| ASKHA_NBD_ROK_GNE |
cd24060 |
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ... |
6-200 |
1.56e-19 |
|
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.
Pssm-ID: 466910 [Multi-domain] Cd Length: 305 Bit Score: 86.32 E-value: 1.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 6 AIEAGGTKFCCAIGNEHGDILEEMTIPTEHPEKTLQKLIPFF--------EQHDIEALGVG-SFGpicvQKDDPSYGYIM 76
Cdd:cd24060 4 AVDLGGTNLRVAIVSMKGEIVKKYTQPNPKTYEERIDLILQMcveaaseaVKLNCRILGVGiSTG----GRVNPREGIVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 77 NTPKV--EWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHSH--PE 152
Cdd:cd24060 80 HSTKLiqEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGIGGGIILNHELIHGSSFcaAE 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 489306294 153 MGHILVrqhESDVFEGVCPAHGtCLEGLAAGPAIEKRwgksAKELTEE 200
Cdd:cd24060 160 LGHIVV---SLDGPDCMCGSHG-CVEAYASGMALQRE----AKKLHDE 199
|
|
| ASKHA_NBD_ROK_EcNanK-like |
cd24069 |
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ... |
6-281 |
5.39e-19 |
|
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466919 [Multi-domain] Cd Length: 283 Bit Score: 84.64 E-value: 5.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 6 AIEAGGTKFCCAIgNEHGDILEEMTIPTEHPE------KTLQKLIPFFEQHDiEALGVGSFGPIcvqkDDPSYGYIMNTP 79
Cdd:cd24069 2 AIDIGGTKIAAAL-IGNGQIIDRRQIPTPRSGtpealaDALASLLADYQGQF-DRVAVASTGII----RDGVLTALNPKN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 80 KVEWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGH----SHpeMGH 155
Cdd:cd24069 76 LGGLSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLVLNGQLLTGPnglaGH--IGH 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 156 ILVRQHESdvfegVCPAHGT-CLEGLAAGPAIEK---RWGK---SAKELTE---EKSVWALE-----ADYLAQALMQYSL 220
Cdd:cd24069 154 TLADPPGP-----VCGCGRRgCVEAIASGTAIAAaasEILGepvDAKDVFErarSGDEEAARlidraARALADLIADLKA 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489306294 221 ILSPERIIMGGGVmkqkQLFPLIREKLVAYLNdyvDLPPLdtY---IVSPGLEDKAGMTGALLL 281
Cdd:cd24069 229 TLDLDCVVIGGSV----GLAEGFLERVEQYLA---DEPAI--FrvsLEPARLGQDAGLLGAALL 283
|
|
| ASKHA_NBD_ROK_NAGK |
cd24057 |
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ... |
4-281 |
9.62e-19 |
|
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466907 [Multi-domain] Cd Length: 298 Bit Score: 84.21 E-value: 9.62e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 4 YGAIEAGGTKFCCAIGNEHGDILEEMTIPT--EHPEKTLQKLIPFFEQHDIEA-----LGVGSFGPIcvqkdDPSYG--Y 74
Cdd:cd24057 2 YYGFDIGGTKIEFAVFDEALQLVWTKRVPTptDDYAAFLAAIAELVAEADARFgvkgpVGIGIPGVI-----DPEDGtlI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 75 IMNTPKVEWKhyPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHSH--PE 152
Cdd:cd24057 77 TANIPAAKGR--PLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGLILGTGVGGGLVVNGRLVGGRSGiaGE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 153 MGH------ILVRQHESDVFEGVCPAHGtCLEGLAAGPAIEKRW------GKSAKELT------EEKSVWALEA--DYLA 212
Cdd:cd24057 155 WGHgplpadALLLGYDLPVLRCGCGQTG-CLETYLSGRGLERLYahlygeELDAPEIIaawaagDPQAVAHVDRwlDLLA 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 213 QALMQYSLILSPERIIMGGGVMKqkqlFPLIREKLVAYLNDYVdLPPLDTYIVSPG-LEDKAGMTGALLL 281
Cdd:cd24057 234 GCLANILTALDPDVVVLGGGLSN----FPALIAELPAALPAHL-LSGARTPRIVPArHGDAGGVRGAAFL 298
|
|
| ASKHA_ATPase_ROK_CYANR |
cd24073 |
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ... |
16-231 |
8.71e-18 |
|
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466923 [Multi-domain] Cd Length: 304 Bit Score: 81.44 E-value: 8.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 16 CAIGNEHGDILEEMTIPTE--HPE-------KTLQKLI--PFFEQHDIEALGVGSFGPIcvqkdDPSYGYIMNTPKVEWK 84
Cdd:cd24073 15 AVLTDLRGNVLASHTLPLDsgDPEavaeaiaEAVAELLaqAGLSPDRLLGIGVGLPGLV-----DAETGICRWSPLLGWR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 85 HYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHS--HPEMGHILVrqhE 162
Cdd:cd24073 90 DVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHggAGEIGHTTV---D 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 163 SDvfeG---VCPAHGtCLEGLAAGPAIEKRW---GKSAKELT-EEKSVWALEADYLAQALMQ-------YSL-----ILS 223
Cdd:cd24073 167 PD---GppcRCGKRG-CLEAYASDPAILRQAreaGLRGEPLTiEDLLAAARAGDPAARAILRragralgLALanlvnLLD 242
|
....*...
gi 489306294 224 PERIIMGG 231
Cdd:cd24073 243 PELIIISG 250
|
|
| ASKHA_ATPase_ROK_NagC |
cd24075 |
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ... |
6-247 |
2.02e-17 |
|
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466925 [Multi-domain] Cd Length: 315 Bit Score: 80.49 E-value: 2.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 6 AIEAGGTKFCCAIGNEHGDILEEMTIP--TEHPEKTLQKLIPFFEQ---------HDIEALGVGSFGPIcvqkdDPSYGY 74
Cdd:cd24075 5 AVRLGRHDLTLGLYDLSGELLAEHTVPltALNQEALLSQLIEEIAQflkshrrktQRLIAISITLPGLI-----NPKTGV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 75 IMNTPKVEWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGHSHP--E 152
Cdd:cd24075 80 VHYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNagE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 153 MGHILV-----RQHesdvfegvCPAHGtCLEGLAAGPAIEKRWGK-----SAKELTEE----KSVW--ALEADYLAQALM 216
Cdd:cd24075 160 IGHIQIeplgeRCH--------CGNFG-CLETVASNAAIEQRVKKllkqgYASQLTLQdctiKDICqaALNGDQLAQDVI 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 489306294 217 QYSL------------ILSPERIIMGGGVMK-QKQLFPLIREKL 247
Cdd:cd24075 231 KRAGrylgkviailinLLNPQKIIIAGEITQaDKVLLPVIKKCI 274
|
|
| ASKHA_NBD_ROK_AlsK |
cd24070 |
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ... |
3-282 |
2.46e-16 |
|
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466920 [Multi-domain] Cd Length: 293 Bit Score: 77.20 E-value: 2.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 3 YYGAIEAGGTKFCCAIGNEHGDILEEMTIPT------EHPEKTLQKLI-PFFEQHDIE----ALGVgsfgPICVQKDDps 71
Cdd:cd24070 2 YVLGIDIGGTNIRIGLVDEDGKLLDFEKVPSkdllraGDPVEVLADLIrEYIEEAGLKpaaiVIGV----PGTVDKDR-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 72 yGYIMNTPKV-EWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHGH-- 148
Cdd:cd24070 76 -RTVISTPNIpGLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDDEGVVLGFYIGTGIGNAILINGKPLRGKng 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 149 SHPEMGHILVRQhesdvFEGVCPAHGT-CLEGLAAGPAIEkRWGKSAKELTEEKSV---WALEA------DYLAQALMQY 218
Cdd:cd24070 155 VAGELGHIPVYG-----NGKPCGCGNTgCLETYASGRALE-EIAEEHYPDTPILDIfvdHGDEPeldefvEDLALAIATE 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489306294 219 SLILSPERIIMGGGVMKQKQlFPliREKLVAYLNDYVDLP----PLDTYIVSPGleDKAGMTGALLLA 282
Cdd:cd24070 229 INILDPDAVILGGGVIDMKG-FP--RETLEEYIRKHLRKPypadNLKIIYAELG--PEAGVIGAAIYA 291
|
|
| ASKHA_ATPase_ROK_Mlc |
cd24074 |
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ... |
32-244 |
2.62e-16 |
|
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466924 [Multi-domain] Cd Length: 322 Bit Score: 77.74 E-value: 2.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 32 PTEHPEKTLQKLIPFFEQHDIEALGVGSFGPICVQKDDPSYGYIMNTPKVEWKHYPFIPELEKQLEVPVSFTTDVNAAAL 111
Cdd:cd24074 38 NDPFLDRLLESISEFFSRHQKKLERLTAIAITLPGIIDPESGIVHRLPFYDIKNLPLGEALEQHTGLPVYVQHDISAWTL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 112 GELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLH-GHSHP-EMGHILVRQHESDVFegvCPAHGtCLEGLAAGPAIEKR 189
Cdd:cd24074 118 AERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHaGSSRLgELGHTQIDPYGKRCY---CGNHG-CLETVASIPAILEQ 193
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489306294 190 WGKSAKE------LTEEKSV-----WALEADYLAQALMQYS------------LILSPERIIMGGGVMKQK-QLFPLIR 244
Cdd:cd24074 194 ANQLLEQspdsmlHGQPISIeslcqAALAGDPLAQDIIIQVgrhlgrilailvNLFNPEKILIGSPLNNAAeILFPALS 272
|
|
| ASKHA_ATPase_ROK_YphH-like |
cd24072 |
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ... |
6-247 |
9.95e-14 |
|
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466922 [Multi-domain] Cd Length: 308 Bit Score: 70.14 E-value: 9.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 6 AIEAGGTKFCCAIGNEHGDILEEMT---IPTEHPEKTLQKLIPFFEQ------HDIEALGVGSFGPIcvqkdDPSYGYIM 76
Cdd:cd24072 5 GIVVSPNSLRAQVGNACGELLGEFEyrvITLETPEALIDEIIDCIDRllklwkDRVKGIALAIQGLV-----DSHKGVSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 77 NTPKVEWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVKNELLHG--HSHPEMG 154
Cdd:cd24072 80 WSPGAPWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGasSGSGEIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 155 HIlvrQHESDVFEGVCPAHGtCLEGLAAGPAIEKRWGKSAK-----------------ELTEEKSVWALEADYLAQALMQ 217
Cdd:cd24072 160 HT---KVNPDGARCDCGRRG-CLETVASNSALKRNARVTLKlgpvsadpekltmeqliEALEEGEPIATQIFDRAANAIG 235
|
250 260 270
....*....|....*....|....*....|....*.
gi 489306294 218 YSL-----ILSPERIIM-GGGVMKQKQLFPLIREKL 247
Cdd:cd24072 236 RSLanilnLLNPEQVLLyGRGCRAGDLLLPAIRRAI 271
|
|
| ASKHA_ATPase_ROK_SaXylR-like |
cd24077 |
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ... |
40-284 |
1.05e-13 |
|
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466927 [Multi-domain] Cd Length: 295 Bit Score: 69.88 E-value: 1.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 40 LQKLIPFFeQHDIEALGVGSFGPICVQKddpsygyIMNTPKVEWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTkgAA 119
Cdd:cd24077 51 LISQAPKT-PYGLVGIGIGIHGIVDENE-------IIFTPYYDLEDIDLKEKLEEKFNVPVYLENEANLSALAERT--FS 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 120 KGLNSCLYITVGTGIGAGAVVKNELLHGHS--HPEMGHILVrqhesdVFEGV-CP--AHGtCLEGLAAGPAIEKRWGKS- 193
Cdd:cd24077 121 EDYDNLISISIHSGIGAGIIINNQLYRGYNgfAGEIGHMII------VPNGKpCPcgNKG-CLEQYASEKALLKELSEKk 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 194 -AKELTEEKSVWALEAD-------------YLAQALMQYSLILSPERIIMGGGVMKQ-KQLFPLIREKLVAYLNDYVDLp 258
Cdd:cd24077 194 gLETLTFDDLIQLYNEGdpealelidqfikYLAIGINNIINTFNPEIIIINSSLINEiPELLEKIKEQLSSSFNKYVEI- 272
|
250 260
....*....|....*....|....*.
gi 489306294 259 pldtyIVSPgLEDKAGMTGALLLAIE 284
Cdd:cd24077 273 -----LIST-LGKNATLLGGAAVAIK 292
|
|
| PRK09698 |
PRK09698 |
D-allose kinase; Provisional |
7-284 |
1.36e-13 |
|
D-allose kinase; Provisional
Pssm-ID: 182034 [Multi-domain] Cd Length: 302 Bit Score: 69.63 E-value: 1.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 7 IEAGGTKFCCAIGNEHGDILEEMTIPTEHPEK--TLQKLIPFFEQH------DIEALGVGsFgPICVQKDDPSYGYIMNT 78
Cdd:PRK09698 9 IDMGGTHIRFCLVDAEGEILHCEKKRTAEVIApdLVSGLGEMIDEYlrrfnaRCHGIVMG-F-PALVSKDRRTVISTPNL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 79 PKVEWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGlNSCLYITVGTGIGAGAVVKNELLHGHsH---PEMGH 155
Cdd:PRK09698 87 PLTALDLYDLADKLENTLNCPVFFSRDVNLQLLWDVKENNLTQ-QLVLGAYLGTGMGFAVWMNGAPWTGA-HgvaGELGH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 156 ILV--RQHEsdvfegvCPAHGT-CLEGLAAGPAIeKRWGKSAKE-------LTEEKSVWALEA--DYLAQALMQYSLILS 223
Cdd:PRK09698 165 IPLgdMTQH-------CGCGNPgCLETNCSGMAL-RRWYEQQPRdyplsdlFVHAGDHPFIQSllENLARAIATSINLFD 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489306294 224 PERIIMGGGVMKQKQlFPliREKLVAYLNDYV--DLPPLDTYIVSPGLEDKAGMTGALLLAIE 284
Cdd:PRK09698 237 PDAIILGGGVMDMPA-FP--RETLIAMIQKYLrkPLPYEVVRFIYASSSDFNGAQGAAILAHQ 296
|
|
| ASKHA_NBD_ROK_PPGK |
cd24058 |
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ... |
83-282 |
2.13e-13 |
|
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466908 [Multi-domain] Cd Length: 239 Bit Score: 67.98 E-value: 2.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 83 WKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLN-SCLYITVGTGIGAGAVVKNELLHghsHPEMGHILVRQH 161
Cdd:cd24058 81 WIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKgVVLVLTLGTGIGSALFVDGHLVP---NTELGHLEIRGK 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 162 ESDvfegvcpahgtclEGLAAGPAIEKRWGKSAkelteeksvWAleaDYLAQALMQYSLILSPERIIMGGGVMKqkqlfp 241
Cdd:cd24058 158 DAE-------------ERASLGVRAREDLGWKR---------WA---KRVNKYLQYLERLFNPDLFIIGGGNSK------ 206
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 489306294 242 lireklvaYLNDYVDLPPLDTYIVSPGLEDKAGMTGALLLA 282
Cdd:cd24058 207 --------KADKFLPLLDVKTPVVPAVLRNDAGIVGAALLA 239
|
|
| PRK05082 |
PRK05082 |
N-acetylmannosamine kinase; Provisional |
6-233 |
2.45e-10 |
|
N-acetylmannosamine kinase; Provisional
Pssm-ID: 235338 [Multi-domain] Cd Length: 291 Bit Score: 59.93 E-value: 2.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 6 AIEAGGTKFCCAIGNEHGDILEEMTIPTEH---PE---KTLQKLI-PFfeQHDIEALGVGSFGPIcvqkddpSYGYI--M 76
Cdd:PRK05082 5 AIDIGGTKIAAALVGEDGQIRQRRQIPTPAsqtPEalrQALSALVsPL--QAQADRVAVASTGII-------NDGILtaL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 77 NtPKV--EWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNsCLYITVGTGIGAGAVVKNELLHGHS----H 150
Cdd:PRK05082 76 N-PHNlgGLLHFPLVQTLEQLTDLPTIALNDAQAAAWAEYQALPDDIRN-MVFITVSTGVGGGIVLNGKLLTGPGglagH 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 151 peMGHILvrqheSDVFEGVCPAHGT-CLEGLAAGPAIE---KRW--GKSAKELTEEksvwALEADYLAQALMQYS----- 219
Cdd:PRK05082 154 --IGHTL-----ADPHGPVCGCGRRgCVEAIASGRAIAaaaQGWlaGCDAKTIFER----AGQGDEQAQALINRSaqaia 222
|
250 260
....*....|....*....|.
gi 489306294 220 -LI------LSPERIIMGGGV 233
Cdd:PRK05082 223 rLIadlkatLDCQCVVLGGSV 243
|
|
| PRK09557 |
PRK09557 |
fructokinase; Reviewed |
7-255 |
6.08e-08 |
|
fructokinase; Reviewed
Pssm-ID: 236565 [Multi-domain] Cd Length: 301 Bit Score: 52.72 E-value: 6.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 7 IEAGGTKFCCAIGNEHGDILEEMTIPTEHPE--KTLQKLIPFFEQHDIE-----ALGVGSFGPIcvqkdDPSYGYIMNTP 79
Cdd:PRK09557 5 IDLGGTKIEVIALDDAGEELFRKRLPTPRDDyqQTIEAIATLVDMAEQAtgqrgTVGVGIPGSI-----SPYTGLVKNAN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 80 KVEWKHYPFIPELEKQLEVPVSFTTDVNAAALGELTKGAAKGLNSCLYITVGTGIGAGAVVknellHGHSHP-------E 152
Cdd:PRK09557 80 STWLNGQPLDKDLSARLNREVRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVAI-----NGRVHIggngiagE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489306294 153 MGH---------ILVRQHESDVFegvCPAHGtCLEGLAAGPAI----EKRWGKSAK-----ELTEEKSVWALEA-----D 209
Cdd:PRK09557 155 WGHnplpwmdedELRYRNEVPCY---CGKQG-CIETFISGTGFatdyRRLSGKALKgseiiRLVEEGDPVAELAfrryeD 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 489306294 210 YLAQALMQYSLILSPERIIMGGGVMKQKQLFPlireKLVAYLNDYV 255
Cdd:PRK09557 231 RLAKSLAHVINILDPDVIVLGGGMSNVDRLYP----TLPALLKQYV 272
|
|
| |
