NCBI Conserved Domain Search

Conserved domains on [gi|489307513|ref|WP_003214948|]

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MULTISPECIES: PAS domain-containing hybrid sensor histidine kinase/response regulator [Pseudomonas]

Protein Classification

PAS domain-containing hybrid sensor histidine kinase/response regulator( domain architecture ID 11426751)

PAS domain-containing hybrid sensor histidine kinase/response regulator with an N-terminal domain related to SLC5 solute-binding domains, part of a two-component regulatory system, receives the signal from the sensor partner in a two-component system through its receiver (REC) domain and functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH: 3.40.50.2300|3.30.565.10|3.30.450.20

EC: 2.7.13.3

Gene Ontology: GO:0000160|GO:0000156|GO:0000155|GO:0004673|GO:0007165|GO:0005524

PubMed: 20226724|10339418|10637609|15009198|9382818

SCOP: 4003632|4001957|3000471

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

SLC5sbd

cd10322

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...

7-475

2.45e-62

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.

Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 220.12 E-value: 2.45e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513    7 LIAAVALAYMAIMFAIAFYGDRRHAPL------PPRMRAWVYSLSL-AVYCTSWTFFGAVGQAAEQLWAFLPIYLGPVLL 79
Cdd:cd10322     1 IDLIIVVVYLALLLGIGLYASKKVKSSedfflaGRSLGPWLLAGTLaATWISAGSFVGVAGLAYTYGLSAIWYILGAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   80 LVLAPWVLQKMVLISkqeNITSIADFIAARYGkSQSLAVVVALICLVGVLPYIALQLKGIVLGVNLLIGASADTtgtrsq 159
Cdd:cd10322    81 ALLLALFLAPRLRRL---GKTTIPETILERYY-SKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTV------ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  160 dtALIVSLVLALFTIVFGTRnldatehhRGMVLAIAFESLVKLFAFLAVGAFVTYGLY-DGFDDLFsQAMLAPRLEEYWK 238
Cdd:cd10322   151 --AVIIAAVIVILYTVFGGM--------RAVAWTDVIQGIVMLIGVLVAAIFILSKVGgGGFSALA-AALPALLLALGPG 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  239 ETVNWPSMVVQTGVAMMAIICLPRQFHVTVVENiDPQDLRLAKWVFPAYLILAALFVIPIALGGKMLLPGSVLPDSYVIS 318
Cdd:cd10322   220 GGLGWSTILSLILLTGLGVLALPQVFQRILAAK-DEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLENPDLALPT 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  319 LPLAEAHPALAVLAFIGGASAATGMVIVASIALSTMVSNDMLLPWLLRRSSAERpfevfrhwMLSVRRVSIVIILLLAYV 398
Cdd:cd10322   299 LINSLLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKK--------LLRVSRIAVVVVGVLALL 370

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489307513  399 SYRLLGSSASLatIGQIAFAAVTQLAPAMLGALYWKQANRRGVFAGLAAGTFLWFYTLVLPVtaKSLGWSFSLFPGM 475
Cdd:cd10322   371 LALLPPSILLL--LSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPL--ASPLGIDPIIPAL 443

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

782-1018

2.85e-62

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 212.07 E-value: 2.85e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  782 ALTDAKGVAETASQSKTRFLAAVSHDLMQPLNAARLFSAALSHQNDGMSPDARQLVQHLDSSLRSAEDLISDLLDISRLE 861
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  862 NGKINPQRQPFVLNELFDTLGAEFKALAQEQGLRFRLR--GSRLRVDSDIKLLRRVLQNFLTNAFRY--ADGPVLLGVRR 937
Cdd:COG2205    81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDlpPELPLVYADPELLEQVLANLLDNAIKYspPGGTITISARR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  938 RRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDShqTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLAR 1017
Cdd:COG2205   161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDN--SRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238


                  .
gi 489307513 1018 T 1018
Cdd:COG2205   239 S 239

PAS_7

pfam12860

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

642-756

3.72e-58

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.

Pssm-ID: 432837 [Multi-domain] Cd Length: 115 Bit Score: 195.45 E-value: 3.72e-58

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   642 IENITQGISVVDQSLRLVAWNRRYLELFNYPEGLISVGRPIADIIRYNAERGLCGPGEAEVHVARRLHWMRQGRAHTSER 721
Cdd:pfam12860    1 LENMSQGLSVFDADLRLVAWNRRYRELLDLPEDLVQVGVPFEEIIRYNAERGEYGPGDVEAHVRRRLAAARAGSPHYFER 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 489307513   722 LFPNGRVIELIGNPMPGGGFVMSFTDITAFREAEQ 756
Cdd:pfam12860   81 ERPDGRVIEIRGNPLPDGGFVTTFTDITERRRAEE 115

CheY

COG0784

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...

1033-1155

2.98e-22

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];

Pssm-ID: 440547 [Multi-domain] Cd Length: 128 Bit Score: 93.38 E-value: 2.98e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1033 PLSGAQVLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLDhGETGTELMGWLRAQLAEP- 1111
Cdd:COG0784     2 PLGGKRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAG-PPDLILLDINMP-GMDGLELLRRIRALPRLPd 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 489307513 1112 IPGVVISADGRPEMVAQVHAAGLD-YLAKPVKPAALRALLSRHLP 1155
Cdd:COG0784    80 IPIIALTAYADEEDRERALEAGADdYLTKPVDPEELLEALRRLLA 124

Name

Accession

Description

Interval

E-value

SLC5sbd

cd10322

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...

7-475

2.45e-62

Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 220.12 E-value: 2.45e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513    7 LIAAVALAYMAIMFAIAFYGDRRHAPL------PPRMRAWVYSLSL-AVYCTSWTFFGAVGQAAEQLWAFLPIYLGPVLL 79
Cdd:cd10322     1 IDLIIVVVYLALLLGIGLYASKKVKSSedfflaGRSLGPWLLAGTLaATWISAGSFVGVAGLAYTYGLSAIWYILGAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   80 LVLAPWVLQKMVLISkqeNITSIADFIAARYGkSQSLAVVVALICLVGVLPYIALQLKGIVLGVNLLIGASADTtgtrsq 159
Cdd:cd10322    81 ALLLALFLAPRLRRL---GKTTIPETILERYY-SKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTV------ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  160 dtALIVSLVLALFTIVFGTRnldatehhRGMVLAIAFESLVKLFAFLAVGAFVTYGLY-DGFDDLFsQAMLAPRLEEYWK 238
Cdd:cd10322   151 --AVIIAAVIVILYTVFGGM--------RAVAWTDVIQGIVMLIGVLVAAIFILSKVGgGGFSALA-AALPALLLALGPG 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  239 ETVNWPSMVVQTGVAMMAIICLPRQFHVTVVENiDPQDLRLAKWVFPAYLILAALFVIPIALGGKMLLPGSVLPDSYVIS 318
Cdd:cd10322   220 GGLGWSTILSLILLTGLGVLALPQVFQRILAAK-DEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLENPDLALPT 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  319 LPLAEAHPALAVLAFIGGASAATGMVIVASIALSTMVSNDMLLPWLLRRSSAERpfevfrhwMLSVRRVSIVIILLLAYV 398
Cdd:cd10322   299 LINSLLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKK--------LLRVSRIAVVVVGVLALL 370

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489307513  399 SYRLLGSSASLatIGQIAFAAVTQLAPAMLGALYWKQANRRGVFAGLAAGTFLWFYTLVLPVtaKSLGWSFSLFPGM 475
Cdd:cd10322   371 LALLPPSILLL--LSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPL--ASPLGIDPIIPAL 443

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

782-1018

2.85e-62

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 212.07 E-value: 2.85e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  782 ALTDAKGVAETASQSKTRFLAAVSHDLMQPLNAARLFSAALSHQNDGMSPDARQLVQHLDSSLRSAEDLISDLLDISRLE 861
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  862 NGKINPQRQPFVLNELFDTLGAEFKALAQEQGLRFRLR--GSRLRVDSDIKLLRRVLQNFLTNAFRY--ADGPVLLGVRR 937
Cdd:COG2205    81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDlpPELPLVYADPELLEQVLANLLDNAIKYspPGGTITISARR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  938 RRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDShqTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLAR 1017
Cdd:COG2205   161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDN--SRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238


                  .
gi 489307513 1018 T 1018
Cdd:COG2205   239 S 239

PAS_7

pfam12860

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

642-756

3.72e-58

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.

Pssm-ID: 432837 [Multi-domain] Cd Length: 115 Bit Score: 195.45 E-value: 3.72e-58

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   642 IENITQGISVVDQSLRLVAWNRRYLELFNYPEGLISVGRPIADIIRYNAERGLCGPGEAEVHVARRLHWMRQGRAHTSER 721
Cdd:pfam12860    1 LENMSQGLSVFDADLRLVAWNRRYRELLDLPEDLVQVGVPFEEIIRYNAERGEYGPGDVEAHVRRRLAAARAGSPHYFER 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 489307513   722 LFPNGRVIELIGNPMPGGGFVMSFTDITAFREAEQ 756
Cdd:pfam12860   81 ERPDGRVIEIRGNPLPDGGFVTTFTDITERRRAEE 115

COG4251

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...

510-1018

4.57e-40

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];

Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 156.10 E-value: 4.57e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  510 MLSRTRVSEHWQAGRFIGQEISQRASARSMLSVQINDLLSLAARFVGEERAHQSFVRFAYRQGKGFNPNQNADNDWIAHT 589
Cdd:COG4251     6 LLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  590 ERLLAGVLGASSTRAVVKAAIEGREMQLEDVVRIADEASEVLQFNRALLQGAIENITQGISVVDQSLRLVAWNRRYLELF 669
Cdd:COG4251    86 LLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  670 NYPEGLISVGRPIADIIRYNAERGLCGPGEAEVHVARRLHWMRQGRAHTSERLFPNGRVIELIGNPMPGGGFVMSFTDIT 749
Cdd:COG4251   166 LILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLL 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  750 AFREAEQALTE---ANEGLEQRVTERTHELSQLNVALTdakgvaetasqsktRFLAAVSHDLMQPLNAARLFSAALSHQ- 825
Cdd:COG4251   246 LLLILVLELLElrlELEELEEELEERTAELERSNEELE--------------QFAYVASHDLREPLRKISGFSQLLEEDy 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  826 NDGMSPDARQLVQHLDSSLRSAEDLISDLLDISRLENGKInpQRQPFVLNELFDTLGAEFKALAQEQGLRFRLrGSRLRV 905
Cdd:COG4251   312 GDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQEL--EFEPVDLNELLEEVLEDLEPRIEERGAEIEV-GPLPTV 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  906 DSDIKLLRRVLQNFLTNAFRYAD----GPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLdsHQTRAEKGLGL 981
Cdd:COG4251   389 RGDPTLLRQVFQNLISNAIKYSRpgepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRL--HSRDEYEGTGI 466

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 489307513  982 GLAIadglCR--VLGH--RLSVRSWPGKGSVFSVRVPLART 1018
Cdd:COG4251   467 GLAI----VKkiVERHggRIWVESEPGEGATFYFTLPKAPA 503

PRK15347

two component system sensor kinase;

765-1151

2.63e-34

two component system sensor kinase;

Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 142.47 E-value: 2.63e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  765 LEQRVTERTHELsqlnvalTDAKGVAETASQSKTRFLAAVSHDLMQPLNAArlfSAALSH-QNDGMSPDARQLvqhLDSS 843
Cdd:PRK15347  373 LENKVAERTQAL-------AEAKQRAEQANKRKSEHLTTISHEIRTPLNGV---LGALELlQNTPLTAEQMDL---ADTA 439

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  844 LRSAEDL---ISDLLDISRLENGKINPQRQPFVLNELFDTLGAEFKALAQEQGLRFRLRGSR---LRVDSDIKLLRRVLQ 917
Cdd:PRK15347  440 RQCTLSLlaiINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAhvpLYLHLDSLRLRQILV 519

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  918 NFLTNAFRYA-DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHqtraEKGLGLGLAIADGLCRVLGHR 996
Cdd:PRK15347  520 NLLGNAVKFTeTGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH----SQGTGLGLTIASSLAKMMGGE 595

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  997 LSVRSWPGKGSVFSVRVPLA--------RTQVSAP--------------------------------------------- 1023
Cdd:PRK15347  596 LTLFSTPGVGSCFSLVLPLNeyappeplKGELSAPlalhrqlsawgitcqpghqnpalldpelaylpgrlydllqqiiqg 675

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1024 AKPAQESGQPLS--GAQVLCVDNEES--ILIGMrsLLTRWGCEVWTARDQAQcAALLAEGVRPQLALVDYH---LDHGET 1096
Cdd:PRK15347  676 APNEPVINLPLQpwQLQILLVDDVETnrDIIGM--MLVELGQQVTTAASGTE-ALELGRQHRFDLVLMDIRmpgLDGLET 752

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489307513 1097 gTELMGWLRAQLAEPIPGVVISADGRPEMVAQVHAAGL-DYLAKPVKPAALRALLS 1151
Cdd:PRK15347  753 -TQLWRDDPNNLDPDCMIVALTANAAPEEIHRCKKAGMnHYLTKPVTLAQLARALE 807

HATPase

cd00075

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...

912-1012

2.56e-28

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.

Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 109.61 E-value: 2.56e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAFRYA--DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDShqTRAEKGLGLGLAIADGL 989
Cdd:cd00075     1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78

                          90       100
                  ....*....|....*....|...
gi 489307513  990 CRVLGHRLSVRSWPGKGSVFSVR 1012
Cdd:cd00075    79 VEAHGGRITVESEPGGGTTFTVT 101

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

908-1016

5.14e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 109.28 E-value: 5.14e-28

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513    908 DIKLLRRVLQNFLTNAFRYA--DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDShQTRAEKGLGLGLAI 985
Cdd:smart00387    2 DPDRLRQVLSNLLDNAIKYTpeGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSI 80

                            90       100       110
                    ....*....|....*....|....*....|.
gi 489307513    986 ADGLCRVLGHRLSVRSWPGKGSVFSVRVPLA 1016
Cdd:smart00387   81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

908-1017

1.05e-24

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 99.75 E-value: 1.05e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   908 DIKLLRRVLQNFLTNAFRYADGPVLLGVR-RRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRaekGLGLGLAIA 986
Cdd:pfam02518    2 DELRLRQVLSNLLDNALKHAAKAGEITVTlSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGG---GTGLGLSIV 78

                           90       100       110
                   ....*....|....*....|....*....|.
gi 489307513   987 DGLCRVLGHRLSVRSWPGKGSVFSVRVPLAR 1017
Cdd:pfam02518   79 RKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109

CheY

COG0784

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...

1033-1155

2.98e-22

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];

Pssm-ID: 440547 [Multi-domain] Cd Length: 128 Bit Score: 93.38 E-value: 2.98e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1033 PLSGAQVLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLDhGETGTELMGWLRAQLAEP- 1111
Cdd:COG0784     2 PLGGKRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAG-PPDLILLDINMP-GMDGLELLRRIRALPRLPd 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 489307513 1112 IPGVVISADGRPEMVAQVHAAGLD-YLAKPVKPAALRALLSRHLP 1155
Cdd:COG0784    80 IPIIALTAYADEEDRERALEAGADdYLTKPVDPEELLEALRRLLA 124

REC

cd00156

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...

1040-1140

2.95e-17

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381085 [Multi-domain] Cd Length: 99 Bit Score: 78.04 E-value: 2.95e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1040 LCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLdHGETGTELMGWLRaQLAEPIPGVVISA 1119
Cdd:cd00156     1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREE-RPDLVLLDLMM-PGMDGLELLRKLR-ELPPDIPVIVLTA 77

                          90       100
                  ....*....|....*....|..
gi 489307513 1120 DGRPEMVAQ-VHAAGLDYLAKP 1140
Cdd:cd00156    78 KADEEDAVRaLELGADDYLVKP 99

Response_reg

pfam00072

Response regulator receiver domain; This domain receives the signal from the sensor partner in ...

1039-1150

1.10e-11

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.

Pssm-ID: 395025 [Multi-domain] Cd Length: 111 Bit Score: 62.55 E-value: 1.10e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLDhGETGTELMGWLRaQLAEPIPGVVIS 1118
Cdd:pfam00072    1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEE-RPDLILLDINMP-GMDGLELLKRIR-RRDPTTPVIILT 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 489307513  1119 ADGRPEMVAQVHAAG-LDYLAKPVKPAALRALL 1150
Cdd:pfam00072   78 AHGDEDDAVEALEAGaDDFLSKPFDPDELLAAI 110

PAS

COG2202

PAS domain [Signal transduction mechanisms];

626-801

1.91e-10

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 62.73 E-value: 1.91e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  626 EASEVLQFNRALLQGAIENITQGISVVDQSLRLVAWNRRYLELFNYPEGLIsVGRPIADIIrynaerglcGPGEAEVHVA 705
Cdd:COG2202     1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEEL-LGKTLRDLL---------PPEDDDEFLE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  706 RRLHWMRQGRAHTSERLF--PNGRVI--ELIGNPMPGG-----GFVMSFTDITAFREAEQALTEANEGLEQRVterthEL 776
Cdd:COG2202    71 LLRAALAGGGVWRGELRNrrKDGSLFwvELSISPVRDEdgeitGFVGIARDITERKRAEEALRESEERLRLLV-----EN 145

                         170       180
                  ....*....|....*....|....*
gi 489307513  777 SQLNVALTDAKGVAETASQSKTRFL 801
Cdd:COG2202   146 APDGIFVLDLDGRILYVNPAAEELL 170

SSF

pfam00474

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...

36-448

7.41e-09

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.

Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 59.28 E-value: 7.41e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513    36 RMRAWVYSLSLAV-YCTSWTFFGAVGQAAEQLWAFLPIYLGPVLLLVLAPWVLQKmvlISKQENITSIADFIAARYGKSQ 114
Cdd:pfam00474    7 SMTGFVNGLSLAAsYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAP---RLRNLGAYTMPDYLRKRFGGKR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   115 SLAVVVALICLVGVLPYIALQLKGIVLGVNLLIGASADTTgtrsqdtALIVSLVLALFTIVFGTRNLDATEHHRGMVLAI 194
Cdd:pfam00474   84 ILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTA-------VLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLF 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   195 AfESLVKLFAFLAVGafvtyglydGFDDLFSQAMLA-PRLEEYWK------------ETVNWPSMVV-QTGVAMMAIICL 260
Cdd:pfam00474  157 G-TIILMIIVFHEVG---------GYSSAVEKYMTAdPNGVDLYTpdglhilrdpltGLSLWPGLVLgTTGLPHILQRCL 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   261 PRQFHVTVVENIdpqdlRLAKWVFPAYLILAalfvIPIALGGKMLLpgSVLPDSYVISLPLAE-AHPALAV-------LA 332
Cdd:pfam00474  227 AAKDAKCIRCGV-----LILTPMFIIVMPGM----ISRGLFAIALA--GANPRACGTVVGCSNiAYPTLAVklgppglAG 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   333 FIGGASAATGMVIVASIAL--STMVSNDMLLpwLLRRSSAERPFEVFRhwmlsvrrVSIVIILLLAYVSYRLLGSSASLA 410
Cdd:pfam00474  296 IMLAVMLAAIMSTLTSQLLssSSAFTHDLYK--NIRRKASATEKELVG--------RSRIIVLVVISLAILLAVQPAQMG 365

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 489307513   411 TIGQIAFA---AVTQLAPAMLGALYWKQANRRGVFAGLAAG 448
Cdd:pfam00474  366 IAFLVQLAfagLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406

sensory_box

TIGR00229

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

641-758

2.69e-08

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 53.45 E-value: 2.69e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   641 AIENITQGISVVDQSLRLVAWNRRYLELFNY-PEGLIsvGRPIADIIRynaerglcgPGEAEVHVAR-RLHWMRQGRAHT 718
Cdd:TIGR00229    8 IFESSPDAIIVIDLEGNILYVNPAFEEIFGYsAEELI--GRNVLELIP---------EEDREEVRERiERRLEGEPEPVS 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 489307513   719 SERLFP--NGRVI--ELIGNPMP--GG--GFVMSFTDITAFREAEQAL 758
Cdd:TIGR00229   77 EERRVRrkDGSEIwvEVSVSPIRtnGGelGVVGIVRDITERKEAEEAL 124

sss

TIGR00813

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...

36-448

2.18e-07

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 54.62 E-value: 2.18e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513    36 RMRAWVYSLSL-AVYCTSWTFFGAVGQAAEQLWAFLPIYLGPVLLLVLAPWVLqkmVLISKQENITSIADFIAARYGKS- 113
Cdd:TIGR00813    4 SLGGWVVAASLfASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLF---VPIFINNGAYTMPEYLEKRFGKRi 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   114 -QSLAVVVALICLVGvlpYIALQLKGIVLGVNLLIGASADTTgtrsqdtALIVSLVLALFTIVFGTRnldatehhrGMVL 192
Cdd:TIGR00813   81 lRGLSVLSLILYIFL---YMSVDLFSGALLIELITGLDLYLS-------LLLLGAITILYTVFGGLK---------AVVW 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   193 AIAFESLVKLFAFLAVGAFVTY--GLYDGFDDLFSQAMLAPRLEEYWKETVNWPS---MVVQTGVAMMAIICLPRQF-HV 266
Cdd:TIGR00813  142 TDTIQAVIMILGTFILPVFAFSevGGLGTFVEKASQAAPTNPSPDDLYDFFRDPStsdLPWGAGVFGLPHVALWYWTnQV 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   267 TVVENIDPQDLRLAKwvfpAYLILAA-LFVIPIALggkMLLPG--------SVLPDSYVISLPLAE-AHPALAVL---AF 333
Cdd:TIGR00813  222 IVQRCLAAKSAKHAK----KGCLISGvLKLLPMFG---AVLPGliaralytDIDPALAGAVNQNSDqAYPLLVQElmpPG 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   334 IGGASAATGMVIVAS------IALSTMVSNDMLLPWllRRSSAERpfevfRHWMLSVRRVSIVIILLLAYVsyrllgssA 407
Cdd:TIGR00813  295 LAGLFLAAILAAVMStlssqlNSASTVFTMDLYKKI--IRPNASG-----EKKIVMRGRIAVLVAAVIAGF--------V 359

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 489307513   408 SLATIGQIAFAAVT-------QLAPAMLGALYWKQANRRGVFAGLAAG 448
Cdd:TIGR00813  360 AAAQGGQVLQYVQEafgglgaPFLPVFLLGIFWKRMNAKGALAGMIAG 407

PRK13435

response regulator; Provisional

1039-1152

1.51e-04

response regulator; Provisional

Pssm-ID: 184052 [Multi-domain] Cd Length: 145 Bit Score: 43.12 E-value: 1.51e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGVRPQLALVDYHLDHGETGTElmgwLRAQLAEPIPGVVIS 1118
Cdd:PRK13435    8 VLIVEDEALIALELEKLVEEAGHEVVGIAMSSEQAIALGRRRQPDVALVDVHLADGPTGVE----VARRLSADGGVEVVF 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 489307513 1119 ADGRPEMVAQVHAAGLDYLAKPVKPAALRALLSR 1152
Cdd:PRK13435   84 MTGNPERVPHDFAGALGVIAKPYSPRGVARALSY 117

PAS

smart00091

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

636-686

3.14e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 40.08 E-value: 3.14e-04

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 489307513    636 ALLQGAIENITQGISVVDQSLRLVAWNRRYLELFNYPEGLIsVGRPIADII 686
Cdd:smart00091    1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEEL-IGKSLLELI 50

Name

Accession

Description

Interval

E-value

SLC5sbd

cd10322

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...

7-475

2.45e-62

Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 220.12 E-value: 2.45e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513    7 LIAAVALAYMAIMFAIAFYGDRRHAPL------PPRMRAWVYSLSL-AVYCTSWTFFGAVGQAAEQLWAFLPIYLGPVLL 79
Cdd:cd10322     1 IDLIIVVVYLALLLGIGLYASKKVKSSedfflaGRSLGPWLLAGTLaATWISAGSFVGVAGLAYTYGLSAIWYILGAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   80 LVLAPWVLQKMVLISkqeNITSIADFIAARYGkSQSLAVVVALICLVGVLPYIALQLKGIVLGVNLLIGASADTtgtrsq 159
Cdd:cd10322    81 ALLLALFLAPRLRRL---GKTTIPETILERYY-SKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTV------ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  160 dtALIVSLVLALFTIVFGTRnldatehhRGMVLAIAFESLVKLFAFLAVGAFVTYGLY-DGFDDLFsQAMLAPRLEEYWK 238
Cdd:cd10322   151 --AVIIAAVIVILYTVFGGM--------RAVAWTDVIQGIVMLIGVLVAAIFILSKVGgGGFSALA-AALPALLLALGPG 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  239 ETVNWPSMVVQTGVAMMAIICLPRQFHVTVVENiDPQDLRLAKWVFPAYLILAALFVIPIALGGKMLLPGSVLPDSYVIS 318
Cdd:cd10322   220 GGLGWSTILSLILLTGLGVLALPQVFQRILAAK-DEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLENPDLALPT 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  319 LPLAEAHPALAVLAFIGGASAATGMVIVASIALSTMVSNDMLLPWLLRRSSAERpfevfrhwMLSVRRVSIVIILLLAYV 398
Cdd:cd10322   299 LINSLLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKK--------LLRVSRIAVVVVGVLALL 370

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489307513  399 SYRLLGSSASLatIGQIAFAAVTQLAPAMLGALYWKQANRRGVFAGLAAGTFLWFYTLVLPVtaKSLGWSFSLFPGM 475
Cdd:cd10322   371 LALLPPSILLL--LSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPL--ASPLGIDPIIPAL 443

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

782-1018

2.85e-62

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 212.07 E-value: 2.85e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  782 ALTDAKGVAETASQSKTRFLAAVSHDLMQPLNAARLFSAALSHQNDGMSPDARQLVQHLDSSLRSAEDLISDLLDISRLE 861
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  862 NGKINPQRQPFVLNELFDTLGAEFKALAQEQGLRFRLR--GSRLRVDSDIKLLRRVLQNFLTNAFRY--ADGPVLLGVRR 937
Cdd:COG2205    81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDlpPELPLVYADPELLEQVLANLLDNAIKYspPGGTITISARR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  938 RRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDShqTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLAR 1017
Cdd:COG2205   161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDN--SRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238


                  .
gi 489307513 1018 T 1018
Cdd:COG2205   239 S 239

BaeS

COG0642

Signal transduction histidine kinase [Signal transduction mechanisms];

764-1016

4.12e-61

Signal transduction histidine kinase [Signal transduction mechanisms];

Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 212.08 E-value: 4.12e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  764 GLEQRVTERTHELSQLNVALTDAKGVAETASQSKTRFLAAVSHDLMQPLNAARLFSAALSHQNDgmsPDARQLVQHLDSS 843
Cdd:COG0642    77 LLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD---EEQREYLETILRS 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  844 LRSAEDLISDLLDISRLENGKINPQRQPFVLNELFDTLGAEFKALAQEQGLRFRLR--GSRLRVDSDIKLLRRVLQNFLT 921
Cdd:COG0642   154 ADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlpDDLPTVRGDPDRLRQVLLNLLS 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  922 NAFRYAD--GPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDShqTRAEKGLGLGLAIADGLCRVLGHRLSV 999
Cdd:COG0642   234 NAIKYTPegGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDP--SRRGGGTGLGLAIVKRIVELHGGTIEV 311

                         250
                  ....*....|....*..
gi 489307513 1000 RSWPGKGSVFSVRVPLA 1016
Cdd:COG0642   312 ESEPGKGTTFTVTLPLA 328

PAS_7

pfam12860

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

642-756

3.72e-58

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.

Pssm-ID: 432837 [Multi-domain] Cd Length: 115 Bit Score: 195.45 E-value: 3.72e-58

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   642 IENITQGISVVDQSLRLVAWNRRYLELFNYPEGLISVGRPIADIIRYNAERGLCGPGEAEVHVARRLHWMRQGRAHTSER 721
Cdd:pfam12860    1 LENMSQGLSVFDADLRLVAWNRRYRELLDLPEDLVQVGVPFEEIIRYNAERGEYGPGDVEAHVRRRLAAARAGSPHYFER 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 489307513   722 LFPNGRVIELIGNPMPGGGFVMSFTDITAFREAEQ 756
Cdd:pfam12860   81 ERPDGRVIEIRGNPLPDGGFVTTFTDITERRRAEE 115

WalK

COG5002

Sensor histidine kinase WalK [Signal transduction mechanisms];

791-1018

7.50e-52

Sensor histidine kinase WalK [Signal transduction mechanisms];

Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 187.84 E-value: 7.50e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  791 ETASQSKTRFLAAVSHDLMQPLNAARLFSAALSHQNDGMSPDARQLVQHLDSSLRSAEDLISDLLDISRLENGKINPQRQ 870
Cdd:COG5002   159 ERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKE 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  871 PFVLNELFDTLGAEFKALAQEQGLRFRLRGSR--LRVDSDIKLLRRVLQNFLTNAFRY--ADGPVLLGVRRRRGELCLEV 946
Cdd:COG5002   239 PVDLAELLEEVVEELRPLAEEKGIELELDLPEdpLLVLGDPDRLEQVLTNLLDNAIKYtpEGGTITVSLREEDDQVRISV 318

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489307513  947 WDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLART 1018
Cdd:COG5002   319 RDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390

COG4251

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...

510-1018

4.57e-40

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];

Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 156.10 E-value: 4.57e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  510 MLSRTRVSEHWQAGRFIGQEISQRASARSMLSVQINDLLSLAARFVGEERAHQSFVRFAYRQGKGFNPNQNADNDWIAHT 589
Cdd:COG4251     6 LLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  590 ERLLAGVLGASSTRAVVKAAIEGREMQLEDVVRIADEASEVLQFNRALLQGAIENITQGISVVDQSLRLVAWNRRYLELF 669
Cdd:COG4251    86 LLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  670 NYPEGLISVGRPIADIIRYNAERGLCGPGEAEVHVARRLHWMRQGRAHTSERLFPNGRVIELIGNPMPGGGFVMSFTDIT 749
Cdd:COG4251   166 LILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLL 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  750 AFREAEQALTE---ANEGLEQRVTERTHELSQLNVALTdakgvaetasqsktRFLAAVSHDLMQPLNAARLFSAALSHQ- 825
Cdd:COG4251   246 LLLILVLELLElrlELEELEEELEERTAELERSNEELE--------------QFAYVASHDLREPLRKISGFSQLLEEDy 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  826 NDGMSPDARQLVQHLDSSLRSAEDLISDLLDISRLENGKInpQRQPFVLNELFDTLGAEFKALAQEQGLRFRLrGSRLRV 905
Cdd:COG4251   312 GDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQEL--EFEPVDLNELLEEVLEDLEPRIEERGAEIEV-GPLPTV 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  906 DSDIKLLRRVLQNFLTNAFRYAD----GPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLdsHQTRAEKGLGL 981
Cdd:COG4251   389 RGDPTLLRQVFQNLISNAIKYSRpgepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRL--HSRDEYEGTGI 466

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 489307513  982 GLAIadglCR--VLGH--RLSVRSWPGKGSVFSVRVPLART 1018
Cdd:COG4251   467 GLAI----VKkiVERHggRIWVESEPGEGATFYFTLPKAPA 503

PutP

COG0591

Na+/proline symporter [Amino acid transport and metabolism];

5-475

5.85e-39

Na+/proline symporter [Amino acid transport and metabolism];

Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 152.28 E-value: 5.85e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513    5 SGLIAAVALAYMAIMFAIAFYGDRRHAPLPP------RMRAWVYSLSL-AVYCTSWTFFGAVGQAAEQ----LWAFLPIY 73
Cdd:COG0591     2 STLDLIIIILYLLLLLGIGLYASRRTKSLEDyflagrSLGWWVLALSLgATWLSAWTFLGVPGLAYAYglsaLWYALGYA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   74 LGPVLL-LVLAPWVlqkmvlisKQENITSIADFIAARYGKSqsLAVVVALICLVGVLPYIALQLKGIVLGVNLLIGASAD 152
Cdd:COG0591    82 LGALLLaLFFAPRL--------RRLGALTIPEFLEKRFGRG--LRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYW 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  153 TTgtrsqdtALIVSLVLALFTiVFGtrnldatehhrGMvLAIAFESLVK---LFAFLAVGAFVTYGLYDGFDDLFSQAML 229
Cdd:COG0591   152 LG-------ILIGALIVLLYT-VLG-----------GL-RAVAWTDVLQgilMLVGLILLLIVALSALGGFGELFAALPA 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  230 APRLEEYWKETVNWPSMVVQTGVAMMAIICLPRQFHVTVVENIDPQDLRLAKWVFPAYLILAALFVIPIALGGKMLLPGS 309
Cdd:COG0591   212 PGLLSLFPGLGFTGWLAFLGLFLAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDL 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  310 VLPDSYVIsLP---LAEAHPALAVLAFIGGASAAtgMVIVAS--IALSTMVSNDMLLPWLLRRSSAERpfevfrhwMLSV 384
Cdd:COG0591   292 PLADPDLA-LPlliLELLPPGLAGLLLAAILAAA--MSTADSqlLAASSVFTRDIYKPFIKPKASDKQ--------LLRV 360

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  385 RRVSIVIILLLAYVSyrLLGSSASLATIGQIAFAAVTQ-LAPAMLGALYWKQANRRGVFAGLAAGTFLWFYTLVLPVTAK 463
Cdd:COG0591   361 SRLAVLVVGLLALLL--ALLFPSSILDLVLLAWGGLGAaLLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLGGPLG 438

                         490
                  ....*....|..
gi 489307513  464 SLGWSFSLFPGM 475
Cdd:COG0591   439 PFGWLYPILPGL 450

NtrY

COG5000

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...

626-1017

1.74e-35

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];

Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 140.48 E-value: 1.74e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  626 EASEVLQFNRALLQGAIENITQGISVVDQSLRLVAWNRRYLELFNYPEGLIsVGRPIADIIRynaerglCGPGEAEVHVA 705
Cdd:COG5000    80 EQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEEL-IGKPLEELLP-------ELDLAELLREA 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  706 RRLHWMRQGRAHTSERlfpngRVIELIGNPMPGGGFVMSFTDITafrEAEQAlteanegleqrvtERTHELSQLnvaltd 785
Cdd:COG5000   152 LERGWQEEIELTRDGR-----RTLLVRASPLRDDGYVIVFDDIT---ELLRA-------------ERLAAWGEL------ 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  786 AKGVAetasqsktrflaavsHDLMQPLNAARLFSAALSHQ-NDGMSPDARQLVQHLDSSLRSAEDL---ISDLLDISRLE 861
Cdd:COG5000   205 ARRIA---------------HEIKNPLTPIQLSAERLRRKlADKLEEDREDLERALDTIIRQVDRLkriVDEFLDFARLP 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  862 NgkinPQRQPFVLNELFDTLGAEFKALAQEQGLRFRLR--GSRLRVDSDIKLLRRVLQNFLTNAfRYA---DGPVLLGVR 936
Cdd:COG5000   270 E----PQLEPVDLNELLREVLALYEPALKEKDIRLELDldPDLPEVLADRDQLEQVLINLLKNA-IEAieeGGEIEVSTR 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  937 RRRGELCLEVWDRGPGIPQDKQKVIFEEFkrldshQTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLA 1016
Cdd:COG5000   345 REDGRVRIEVSDNGPGIPEEVLERIFEPF------FTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLA 418


                  .
gi 489307513 1017 R 1017
Cdd:COG5000   419 E 419

PRK15347

two component system sensor kinase;

765-1151

2.63e-34

two component system sensor kinase;

Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 142.47 E-value: 2.63e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  765 LEQRVTERTHELsqlnvalTDAKGVAETASQSKTRFLAAVSHDLMQPLNAArlfSAALSH-QNDGMSPDARQLvqhLDSS 843
Cdd:PRK15347  373 LENKVAERTQAL-------AEAKQRAEQANKRKSEHLTTISHEIRTPLNGV---LGALELlQNTPLTAEQMDL---ADTA 439

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  844 LRSAEDL---ISDLLDISRLENGKINPQRQPFVLNELFDTLGAEFKALAQEQGLRFRLRGSR---LRVDSDIKLLRRVLQ 917
Cdd:PRK15347  440 RQCTLSLlaiINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAhvpLYLHLDSLRLRQILV 519

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  918 NFLTNAFRYA-DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHqtraEKGLGLGLAIADGLCRVLGHR 996
Cdd:PRK15347  520 NLLGNAVKFTeTGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH----SQGTGLGLTIASSLAKMMGGE 595

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  997 LSVRSWPGKGSVFSVRVPLA--------RTQVSAP--------------------------------------------- 1023
Cdd:PRK15347  596 LTLFSTPGVGSCFSLVLPLNeyappeplKGELSAPlalhrqlsawgitcqpghqnpalldpelaylpgrlydllqqiiqg 675

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1024 AKPAQESGQPLS--GAQVLCVDNEES--ILIGMrsLLTRWGCEVWTARDQAQcAALLAEGVRPQLALVDYH---LDHGET 1096
Cdd:PRK15347  676 APNEPVINLPLQpwQLQILLVDDVETnrDIIGM--MLVELGQQVTTAASGTE-ALELGRQHRFDLVLMDIRmpgLDGLET 752

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489307513 1097 gTELMGWLRAQLAEPIPGVVISADGRPEMVAQVHAAGL-DYLAKPVKPAALRALLS 1151
Cdd:PRK15347  753 -TQLWRDDPNNLDPDCMIVALTANAAPEEIHRCKKAGMnHYLTKPVTLAQLARALE 807

NtrB

COG3852

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

631-1019

3.29e-33

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 132.28 E-value: 3.29e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  631 LQFNRALLQGAIENITQGISVVDQSLRLVAWNRRYLELFNYPEGLIsVGRPIADIIRYNAErglcgpgeaevHVARRLHW 710
Cdd:COG3852     2 LRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEEL-LGRPLAELFPEDSP-----------LRELLERA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  711 MRQGRAHTSERL---FPNG--RVIELIGNPMPG----GGFVMSFTDITAFREAEQALTEAnegleqrvterthelSQLNV 781
Cdd:COG3852    70 LAEGQPVTEREVtlrRKDGeeRPVDVSVSPLRDaegeGGVLLVLRDITERKRLERELRRA---------------EKLAA 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  782 ALTDAKGVAetasqsktrflaavsHDLMQPLNAARLFSAALSHQNDgmSPDARQLVQHLDSSLRSAEDLISDLLDISRLE 861
Cdd:COG3852   135 VGELAAGLA---------------HEIRNPLTGIRGAAQLLERELP--DDELREYTQLIIEEADRLNNLVDRLLSFSRPR 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  862 NgkinPQRQPF----VLNELFDTLGAEFKALAQeqgLRFRLRGSRLRVDSDIKLLRRVLQNFLTNAF------------- 924
Cdd:COG3852   198 P----PEREPVnlheVLERVLELLRAEAPKNIR---IVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAeampeggtitirt 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  925 RYADGpVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFkrldshQTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPG 1004
Cdd:COG3852   271 RVERQ-VTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPF------FTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPG 343

                         410
                  ....*....|....*
gi 489307513 1005 KGSVFSVRVPLARTQ 1019
Cdd:COG3852   344 KGTTFRIYLPLEQAE 358

PRK11466

hybrid sensory histidine kinase TorS; Provisional

750-1116

6.16e-33

hybrid sensory histidine kinase TorS; Provisional

Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 138.11 E-value: 6.16e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  750 AFREAEQALTEANEGLEQRVTERTHELSQLNVALTDAKGVAETASQSKTRFLAAVSHDLMQPLNAArLFSAALSHQNDgM 829
Cdd:PRK11466  397 AFRSNVHALNRHREQLAAQVKARTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGI-LGTAQLLADNP-A 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  830 SPDARQLVQHLDSSLRSAEDLISDLLDISRLENGKINP--QRQPFVLNELFDTlgaefkALAQEQGlrfRLRGSRLRVDS 907
Cdd:PRK11466  475 LNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVsvSDEPFEPRPLLES------TLQLMSG---RVKGRPIRLAT 545

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  908 DI------------KLLRRVLQNFLTNAFRYAD-GPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQtr 974
Cdd:PRK11466  546 DIaddlptalmgdpRRIRQVITNLLSNALRFTDeGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR-- 623

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  975 aeKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLARTQVSAPAKPAQesGQPLSGAQVLCV-DNEESILIGMR 1053
Cdd:PRK11466  624 --GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVATAPVPKTVNQ--AVRLDGLRLLLIeDNPLTQRITAE 699

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489307513 1054 sLLTRWGCEVWTARDQAQCAALLAEGVRPQLALVDYHLDHGETGTelmgwLRAQLAEPIPGVV 1116
Cdd:PRK11466  700 -MLNTSGAQVVAVGNAAQALETLQNSEPFAAALVDFDLPDYDGIT-----LARQLAQQYPSLV 756

COG4191

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...

663-1016

2.35e-28

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];

Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 117.98 E-value: 2.35e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  663 RRYLELFNYPEGLISVGRPIADIIRYNAERGLCGPGEAEVHVARRLHWMRQGRAHTSERLFPNGRVIELIGNPMPGGGFV 742
Cdd:COG4191    10 LLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  743 MSFTDITAFREAEQALTEANEGLEQRVTERTHELSQLNVALtdakgvAETASQSKT----RFLAAVSHDLMQPLNAARLF 818
Cdd:COG4191    90 LEALLLLLLAALDAEENAELEELERDITELERAEEELRELQ------EQLVQSEKLaalgELAAGIAHEINNPLAAILGN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  819 SAALSH--QNDGMSPDARQLVQHLDSSLRSAEDLISDLLDISRLENgkinPQRQPFVLNELFDTLGAEFKALAQEQG--L 894
Cdd:COG4191   164 AELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRLKARGieV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  895 RFRLRGSRLRVDSDIKLLRRVLQNFLTNAfRYA-----DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEF---K 966
Cdd:COG4191   240 ELDLPPDLPPVLGDPGQLEQVLLNLLINA-IDAmeegeGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFfttK 318

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 489307513  967 RldshqtrAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLA 1016
Cdd:COG4191   319 P-------VGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361

HATPase

cd00075

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...

912-1012

2.56e-28

Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 109.61 E-value: 2.56e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAFRYA--DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDShqTRAEKGLGLGLAIADGL 989
Cdd:cd00075     1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78

                          90       100
                  ....*....|....*....|...
gi 489307513  990 CRVLGHRLSVRSWPGKGSVFSVR 1012
Cdd:cd00075    79 VEAHGGRITVESEPGGGTTFTVT 101

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

908-1016

5.14e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 109.28 E-value: 5.14e-28

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513    908 DIKLLRRVLQNFLTNAFRYA--DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDShQTRAEKGLGLGLAI 985
Cdd:smart00387    2 DPDRLRQVLSNLLDNAIKYTpeGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSI 80

                            90       100       110
                    ....*....|....*....|....*....|.
gi 489307513    986 ADGLCRVLGHRLSVRSWPGKGSVFSVRVPLA 1016
Cdd:smart00387   81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111

PRK10604

sensor protein RstB; Provisional

770-1024

2.69e-26

sensor protein RstB; Provisional

Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 113.54 E-value: 2.69e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  770 TERTH-----ELSQLNVALTDAKGVAETASQSKTRFLAAVSHDLMQPLnaARL-FSAALShqnDGMSPDARQLvqhLDSS 843
Cdd:PRK10604  180 AERIHfdegsSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPL--VRLrYRLEMS---DNLSAAESQA---LNRD 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  844 LRSAEDLISDLLDISRLENGKINPQRQPFVLNELFDTLGAEFKALAQEQGLRFRLRGSRLRVDSDIKLLRRVLQNFLTNA 923
Cdd:PRK10604  252 IGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNA 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  924 FRYADGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAIADGLCRVLGHRLSVRSWP 1003
Cdd:PRK10604  332 LRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESE 411

                         250       260
                  ....*....|....*....|.
gi 489307513 1004 GKGSVFSVRVPLARTQVSAPA 1024
Cdd:PRK10604  412 LGGARFSFSWPVWHNLPQFTS 432

HATPase_EvgS-ArcB-TorS-like

cd16922

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...

912-1015

3.09e-26

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 104.11 E-value: 3.09e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAFRY-ADGPVLLGVRRRRGE-----LCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAI 985
Cdd:cd16922     1 LRQILLNLLGNAIKFtEEGEVTLRVSLEEEEedgvqLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 489307513  986 ADGLCRVLGHRLSVRSWPGKGSVFSVRVPL 1015
Cdd:cd16922    81 SKKLVELMGGDISVESEPGQGSTFTFTLPL 110

PRK10490

sensor protein KdpD; Provisional

801-1015

3.17e-26

sensor protein KdpD; Provisional

Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 116.67 E-value: 3.17e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  801 LAAVSHDLMQPLNAarLFSAA------LSHQNDGMSPDARQLVQHLDSSLRsaedLISDLLDISRLENGKINPQRQPFVL 874
Cdd:PRK10490  668 LAALSHDLRTPLTV--LFGQAeiltldLASEGSPHARQASEIRQQVLNTTR----LVNNLLDMARIQSGGFNLRKEWLTL 741

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  875 NELfdtLGAEFKALA---QEQGLRFRLRGSRLRVDSDIKLLRRVLQNFLTNAFRYADGPVLLGVRRRRGE--LCLEVWDR 949
Cdd:PRK10490  742 EEV---VGSALQMLEpglSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGerLQLDVWDN 818

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489307513  950 GPGIPQDKQKVIFEEFKRldSHQTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPL 1015
Cdd:PRK10490  819 GPGIPPGQEQLIFDKFAR--GNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPL 882

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

791-1152

3.82e-25

aerobic respiration control sensor protein ArcB; Provisional

Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 112.73 E-value: 3.82e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  791 ETASQSKTRFLAAVSHDLMQPLNAArlfsAALSHQNDGMSPDARQLvQHLDSSLRSAEDL---ISDLLDISRLENGKINP 867
Cdd:PRK11091  277 EKASRDKTTFISTISHELRTPLNGI----VGLSRILLDTELTAEQR-KYLKTIHVSAITLgniFNDIIDMDKMERRKLQL 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  868 QRQPFVLNELFDTLGAEFKALAQEQGLRFRL-RGSRL--RVDSDIKLLRRVLQNFLTNAFRY-ADGPVLLGVRRRRGE-L 942
Cdd:PRK11091  352 DNQPIDFTDFLADLENLSGLQAEQKGLRFDLePLLPLphKVITDGTRLRQILWNLISNAVKFtQQGGVTVRVRYEEGDmL 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  943 CLEVWDRGPGIPQDKQKVIFEEFKRL-DSHQTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLARTQVS 1021
Cdd:PRK11091  432 TFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVAEE 511

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1022 APAKPAQESgQPLSGAQVLCVDNEESILIGMRSLLTRWGCEVwtarDQAQCAALLAEGVRP---QLALVDYHL-DHgeTG 1097
Cdd:PRK11091  512 VEDAFDEDD-MPLPALNILLVEDIELNVIVARSVLEKLGNSV----DVAMTGKEALEMFDPdeyDLVLLDIQLpDM--TG 584

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489307513 1098 TELMGWLRAQLAepipgvvisADGRPEMVA----------QVHAAGLD-YLAKPVKPAALRALLSR 1152
Cdd:PRK11091  585 LDIARELRERYP---------REDLPPLVAltanvlkdkkEYLDAGMDdVLSKPLSVPALTAMIKK 641

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

908-1017

1.05e-24

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 99.75 E-value: 1.05e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   908 DIKLLRRVLQNFLTNAFRYADGPVLLGVR-RRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRaekGLGLGLAIA 986
Cdd:pfam02518    2 DELRLRQVLSNLLDNALKHAAKAGEITVTlSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGG---GTGLGLSIV 78

                           90       100       110
                   ....*....|....*....|....*....|.
gi 489307513   987 DGLCRVLGHRLSVRSWPGKGSVFSVRVPLAR 1017
Cdd:pfam02518   79 RKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109

PRK10841

two-component system sensor histidine kinase RcsC;

790-1032

4.54e-23

two-component system sensor histidine kinase RcsC;

Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 106.21 E-value: 4.54e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  790 AETASQSKTRFLAAVSHDLMQPL-----NAARLFSAALShqndgmsPDARQLVQHLDSSLRSAEDLISDLLDISRLENG- 863
Cdd:PRK10841  440 AEQASQSKSMFLATVSHELRTPLygiigNLDLLQTKELP-------KGVDRLVTAMNNSSSLLLKIISDILDFSKIESEq 512

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  864 -KINPQrqPFVLNELFDTLGAEFKALAQ----------EQGLRFRLRGSRLRvdsdiklLRRVLQNFLTNAFRYAD-GPV 931
Cdd:PRK10841  513 lKIEPR--EFSPREVINHITANYLPLVVkkrlglycfiEPDVPVALNGDPMR-------LQQVISNLLSNAIKFTDtGCI 583

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  932 LLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSV 1011
Cdd:PRK10841  584 VLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTI 663

                         250       260
                  ....*....|....*....|.
gi 489307513 1012 RVPLARTQVSAPAKPAQESGQ 1032
Cdd:PRK10841  664 RIPLYGAQYPQKKGVEGLQGK 684

PRK09303

histidine kinase;

795-1017

6.24e-23

histidine kinase;

Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 102.34 E-value: 6.24e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  795 QSKTRFLAAVSHDLMQPLNAARLfsaAL------SHQNDGMSPDA--RQLVQHLDSSLRSAEDLISDLLDISRLENGK-- 864
Cdd:PRK09303  149 KFKDRVLAMLAHDLRTPLTAASL---ALetlelgQIDEDTELKPAliEQLQDQARRQLEEIERLITDLLEVGRTRWEAlr 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  865 INPQRqpfvlnelfdtlgAEFKALAQE--QGLRFRLRGSRLRVDSDI-----------KLLRRVLQNFLTNAFRY--ADG 929
Cdd:PRK09303  226 FNPQK-------------LDLGSLCQEviLELEKRWLAKSLEIQTDIpsdlpsvyadqERIRQVLLNLLDNAIKYtpEGG 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  930 PVLLGVRRRRGE-LCLEVWDRGPGIPQDKQKVIFEEFKRLDshQTRAEKGLGLGLAiadgLCR--VLGH--RLSVRSWPG 1004
Cdd:PRK09303  293 TITLSMLHRTTQkVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLS----VCRriVRVHygQIWVDSEPG 366

                         250
                  ....*....|...
gi 489307513 1005 KGSVFSVRVPLAR 1017
Cdd:PRK09303  367 QGSCFHFTLPVYR 379

CheY

COG0784

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...

1033-1155

2.98e-22

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];

Pssm-ID: 440547 [Multi-domain] Cd Length: 128 Bit Score: 93.38 E-value: 2.98e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1033 PLSGAQVLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLDhGETGTELMGWLRAQLAEP- 1111
Cdd:COG0784     2 PLGGKRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAG-PPDLILLDINMP-GMDGLELLRRIRALPRLPd 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 489307513 1112 IPGVVISADGRPEMVAQVHAAGLD-YLAKPVKPAALRALLSRHLP 1155
Cdd:COG0784    80 IPIIALTAYADEEDRERALEAGADdYLTKPVDPEELLEALRRLLA 124

PRK11100

sensory histidine kinase CreC; Provisional

806-1017

6.23e-22

sensory histidine kinase CreC; Provisional

Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 100.69 E-value: 6.23e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  806 HDLMQPLNAARlfsAALSHQNDGMSPDARQ-LVQHLDSSLRSAEDLISDLLDISRLENGKINPQRQPFVLNELFDTLGAE 884
Cdd:PRK11100  265 HELKSPLAAIR---GAAELLQEDPPPEDRArFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEA 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  885 FKALAQEQGLRFRLRGSRLRVDSDIKLLRRVLQNFLTNA--FRYADGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIF 962
Cdd:PRK11100  342 REAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAidFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIF 421

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 489307513  963 EEF---KRLDSHQtraeKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLAR 1017
Cdd:PRK11100  422 ERFyslPRPANGR----KSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475

PRK11107

hybrid sensory histidine kinase BarA; Provisional

776-1153

1.99e-19

hybrid sensory histidine kinase BarA; Provisional

Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 94.53 E-value: 1.99e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  776 LSQL---NVALTDAKGVAETASQSKTRFLAAVSHDLMQPLN-----AARLFSAAL-SHQNDgmspdarqlvqHLDSSLRS 846
Cdd:PRK11107  269 LEQMeiqNVELDLAKKRAQEAARIKSEFLANMSHELRTPLNgvigfTRQTLKTPLtPTQRD-----------YLQTIERS 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  847 AEDL---ISDLLDISRLENGKINPQRQPFVLNELFD---TLGAEfkaLAQEQGLRFRLRgsrlrVDSDIK--------LL 912
Cdd:PRK11107  338 ANNLlaiINDILDFSKLEAGKLVLENIPFSLRETLDevvTLLAH---SAHEKGLELTLN-----IDPDVPdnvigdplRL 409

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  913 RRVLQNFLTNAFRYAD-GPVLLGVRRR-----RGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAIA 986
Cdd:PRK11107  410 QQIITNLVGNAIKFTEsGNIDILVELRalsntKVQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVIT 489

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  987 DGLCRVLGHRLSVRSWPGKGSVFSVRVPLARTQVSAPAKPAQESgqpLSGAQVLCVD-NEESILIGMRsLLTRWGCEVWT 1065
Cdd:PRK11107  490 QKLVNEMGGDISFHSQPNRGSTFWFHLPLDLNPNPIIDGLPTDC---LAGKRLLYVEpNSAAAQATLD-ILSETPLEVTY 565

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1066 ARDQAQCAALlaegvRPQLALVDYHLDHGETGTELMGWLRAqlAEPIPGVVI----SADgrPEMVAQVHAAGLDY-LAKP 1140
Cdd:PRK11107  566 SPTLSQLPEA-----HYDILLLGLPVTFREPLTMLHERLAK--AKSMTDFLIlalpCHE--QVLAEQLKQDGADAcLSKP 636

                         410
                  ....*....|....
gi 489307513 1141 VKPAAL-RALLSRH 1153
Cdd:PRK11107  637 LSHTRLlPALLEPC 650

HATPase_RstB-like

cd16939

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

912-1015

4.93e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.

Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 83.25 E-value: 4.93e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAFRYADGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAIADGLCR 991
Cdd:cd16939     1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80

                          90       100
                  ....*....|....*....|....
gi 489307513  992 VLGHRLSVRSWPGKGSVFSVRVPL 1015
Cdd:cd16939    81 WHGGHVECDDSELGGACFRLTWPR 104

PRK11360

two-component system sensor histidine kinase AtoS;

642-1017

6.42e-19

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 92.34 E-value: 6.42e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  642 IENITQGISVVDQSLRLVAWNRRYLELFNYPEGLIsVGRPIADiirynaergLCGPGEAEVHVARRLhwMRQGRAHTSER 721
Cdd:PRK11360  268 LESIADGVIAIDRQGKITTMNPAAEVITGLQRHEL-VGKPYSE---------LFPPNTPFASPLLDT--LEHGTEHVDLE 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  722 L-FPN-GRVIELI----------GNPMpggGFVMSFTDITAFREaeqalteanegLEQRVtERTHELSQLNvaltdakgv 789
Cdd:PRK11360  336 IsFPGrDRTIELSvstsllhnthGEMI---GALVIFSDLTERKR-----------LQRRV-ARQERLAALG--------- 391

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  790 aetasqsktRFLAAVSHDLMQPLNAARLFSAALSHQNDGMS-----PDARQLVQHLDSslrsaedLISDLLDISRlengK 864
Cdd:PRK11360  392 ---------ELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPsqeylSVVLREVDRLNK-------VIDQLLEFSR----P 451

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  865 INPQRQPFVLNELFDTLGAEFKALAQEQGLRFR--LRGSRLRVDSDIKLLRRVLQNFLTNAFRYADGPVLLGVRRRR--- 939
Cdd:PRK11360  452 RESQWQPVSLNALVEEVLQLFQTAGVQARVDFEteLDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQysd 531

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489307513  940 GELCLEVWDRGPGIPQDKQKVIFEEFkrldsHQTRAeKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLAR 1017
Cdd:PRK11360  532 GQVAVSIEDNGCGIDPELLKKIFDPF-----FTTKA-KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603

PRK09959

acid-sensing system histidine kinase EvgS;

760-1071

2.25e-18

acid-sensing system histidine kinase EvgS;

Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 91.33 E-value: 2.25e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  760 EANEGLEQRVTERTHELSQLNV---------------------ALTDAKGVAETASQSKTRFLAAVSHDLMQPLNAARLF 818
Cdd:PRK09959  654 EIDNGIEKRCINHWHTLCNLPAsdhavyicgwqditetrdlihALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGF 733

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  819 SAALShqNDGMSPDAR-QLVQHLDSSLRSAEDLISDLLDISRLENGKINPQRQPFVLNELFDTLGAEFKALAQEQGLRFR 897
Cdd:PRK09959  734 LELLS--GSGLSKEQRvEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALS 811

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  898 LRGS---RLRVDSDIKLLRRVLQNFLTNAFRYA-DGPV-----LLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRl 968
Cdd:PRK09959  812 CSSTfpdHYLVKIDPQAFKQVLSNLLSNALKFTtEGAVkittsLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQ- 890

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  969 dSHQTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLARTQVSAPAKPAQEsgQPLSGAQ---VLCVDNE 1045
Cdd:PRK09959  891 -TSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEISQQVATVEAKAE--QPITLPEklsILIADDH 967

                         330       340
                  ....*....|....*....|....*.
gi 489307513 1046 ESILIGMRSLLTRWGCEVWTARDQAQ 1071
Cdd:PRK09959  968 PTNRLLLKRQLNLLGYDVDEATDGVQ 993

CitA

COG3290

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...

618-1017

3.60e-18

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];

Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 87.98 E-value: 3.60e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  618 EDVVRIADEASEVLQFNRALLQGAIEnitqGISVVDQSLRLVAWNRRYLELFnypeGLISVGRPIADIIRynaERGLCGP 697
Cdd:COG3290    70 ALLLKLLEEIARLVEEREAVLESIRE----GVIAVDRDGRITLINDAARRLL----GLDAIGRPIDEVLA---EVLETGE 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  698 GEAEVHVARRLHWMRQgrahtsERLFPNGRVIelignpmpggGFVMSFTDITafreaeqalteanegleqrvterthELS 777
Cdd:COG3290   139 RDEEILLNGRVLVVNR------VPIRDDGRVV----------GAVATFRDRT-------------------------ELE 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  778 QLNVALTDAKGVAETasqsktrfLAAVSHDLMQPLNAArlfsAALSHQNDgmSPDARQLVQHLDSSLRSAEDLISDLLDI 857
Cdd:COG3290   178 RLEEELEGVKELAEA--------LRAQRHDFRNHLHTI----SGLLQLGE--YDEALEYIDEISEELQELIDSLLSRIGN 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  858 SRLE---NGKINpqrqpfvlnelfdtlgaefkaLAQEQGLRFRLR-GSRLRVDS-DIKLLRRVLQNFLTNAFRYA----- 927
Cdd:COG3290   244 PVLAallLGKAA---------------------RARERGIDLTIDiDSDLPDLPlSDTDLVTILGNLLDNAIEAVeklpe 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  928 -DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEE-FkrldshQTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPGK 1005
Cdd:COG3290   303 eERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERgF------STKLGEGRGLGLALVKQIVEKYGGTIEVESEEGE 376

                         410
                  ....*....|..
gi 489307513 1006 GSVFSVRVPLAR 1017
Cdd:COG3290   377 GTVFTVRLPKEG 388

REC

cd00156

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...

1040-1140

2.95e-17

Pssm-ID: 381085 [Multi-domain] Cd Length: 99 Bit Score: 78.04 E-value: 2.95e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1040 LCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLdHGETGTELMGWLRaQLAEPIPGVVISA 1119
Cdd:cd00156     1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREE-RPDLVLLDLMM-PGMDGLELLRKLR-ELPPDIPVIVLTA 77

                          90       100
                  ....*....|....*....|..
gi 489307513 1120 DGRPEMVAQ-VHAAGLDYLAKP 1140
Cdd:cd00156    78 KADEEDAVRaLELGADDYLVKP 99

HATPase_CpxA-like

cd16949

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

912-1015

3.08e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.

Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 78.14 E-value: 3.08e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAFRYADGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAIADGLCR 991
Cdd:cd16949     1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80

                          90       100
                  ....*....|....*....|....
gi 489307513  992 VLGHRLSVRSWPGKGSVFSVRVPL 1015
Cdd:cd16949    81 QHGGKIKASNRKPGGLRVRIWLPA 104

HATPase_YcbM-like

cd16947

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

908-1011

3.47e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).

Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 78.71 E-value: 3.47e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  908 DIKLLRRVLQNFLTNAFRYADGPVLLGVRRRRGE--LCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAI 985
Cdd:cd16947    17 NTEALQRILKNLISNAIKYGSDGKFLGMTLREDEkhVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTI 96

                          90       100
                  ....*....|....*....|....*.
gi 489307513  986 ADGLCRVLGHRLSVRSWPGKGSVFSV 1011
Cdd:cd16947    97 TKRLAESMGGSIYVNSKPYEKTVFTV 122

KinE

COG5809

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

610-1016

3.90e-17

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 85.80 E-value: 3.90e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  610 IEGREMQLEDVVRiADEASEVLQFNRALLQGAIENITQGISVVDQSLRLVAWNRRYLELFNYPEGLISvGRPIADIIRYN 689
Cdd:COG5809   116 IEGMLAISRDITE-RKRMEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELI-GKSILELIHSD 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  690 AERglcgpgeaevHVARRLHWMRQGRAH-TSERLF--PNGRVIELIGNPMP------GGGFVMSFTDITAFREAEQALte 760
Cdd:COG5809   194 DQE----------NVAAFISQLLKDGGIaQGEVRFwtKDGRWRLLEASGAPikkngeVDGIVIIFRDITERKKLEELL-- 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  761 anegleqRVTERTHELSQLnvaltdakgvaetasqsktrfLAAVSHDLMQPLNAARLFSAALShqnDGMSPDARQLVQHL 840
Cdd:COG5809   262 -------RKSEKLSVVGEL---------------------AAGIAHEIRNPLTSLKGFIQLLK---DTIDEEQKTYLDIM 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  841 DSSLRSAEDLISDLLDISRLENGKInpqrQPFVLNELFDTLGAEFKALAQEQGLRFRLRgsrlrVDSDI-------KLLR 913
Cdd:COG5809   311 LSELDRIESIISEFLVLAKPQAIKY----EPKDLNTLIEEVIPLLQPQALLKNVQIELE-----LEDDIpdilgdeNQLK 381

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  914 RVLQNFLTNAFRYADGPVLLGVRRRR---GELCLEVWDRGPGIPQDKQKVIFEEFkrldshQTRAEKGLGLGLAIADGLC 990
Cdd:COG5809   382 QVFINLLKNAIEAMPEGGNITIETKAeddDKVVISVTDEGCGIPEERLKKLGEPF------YTTKEKGTGLGLMVSYKII 455

                         410       420
                  ....*....|....*....|....*.
gi 489307513  991 RVLGHRLSVRSWPGKGSVFSVRVPLA 1016
Cdd:COG5809   456 EEHGGKITVESEVGKGTTFSITLPIK 481

HATPase_TutC-TodS-like

cd16925

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...

908-1014

1.60e-16

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.

Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 76.38 E-value: 1.60e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  908 DIKLLRRVLQNFLTNAFRYA--DGPVLLGVRRRRGELCL-EVWDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLA 984
Cdd:cd16925     1 DAEKYERVVLNLLSNAFKFTpdGGRIRCILEKFRLNRFLlTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 489307513  985 IADGLCRVLGHRLSVRSWPGKGSVFSVRVP 1014
Cdd:cd16925    81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110

CitB

COG4565

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...

1039-1154

5.10e-16

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];

Pssm-ID: 443622 [Multi-domain] Cd Length: 138 Bit Score: 75.78 E-value: 5.10e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWG--CEVWTARDQAQCAALLAEGvRPQLALVDYHLDhGETGTELMGWLRAQlAEPIPGVV 1116
Cdd:COG4565     6 VLIVEDDPMVAELLRRYLERLPgfEVVGVASSGEEALALLAEH-RPDLILLDIYLP-DGDGLELLRELRAR-GPDVDVIV 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 489307513 1117 ISADGRPEMVAQVHAAG-LDYLAKPVKPAALRALLSRHL 1154
Cdd:COG4565    83 ITAARDPETVREALRAGvVDYLIKPFTFERLREALERYL 121

AtoC

COG2204

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...

1035-1154

1.04e-14

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];

Pssm-ID: 441806 [Multi-domain] Cd Length: 418 Bit Score: 77.70 E-value: 1.04e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1035 SGAQVLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLdHGETGTELMGWLRAQLAEpIPG 1114
Cdd:COG2204     1 SMARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREE-PPDLVLLDLRM-PGMDGLELLRELRALDPD-LPV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 489307513 1115 VVISADGRPEMVAQVHAAG-LDYLAKPVKPAALRALLSRHL 1154
Cdd:COG2204    78 ILLTGYGDVETAVEAIKAGaFDYLTKPFDLEELLAAVERAL 118

PRK13837

two-component system VirA-like sensor kinase;

830-1154

1.05e-14

two-component system VirA-like sensor kinase;

Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 78.95 E-value: 1.05e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  830 SPDARQLVQHLDSSLRSAEDLISDLLDISRlengKINPQRQPFVLNELFDTLGAEFKA-LAQEQGLRFRLRGSRLRVDSD 908
Cdd:PRK13837  482 HSRAARYIDEIISAGARARLIIDQILAFGR----KGERNTKPFDLSELVTEIAPLLRVsLPPGVELDFDQDQEPAVVEGN 557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  909 IKLLRRVLQNFLTNAFRYADGPVLLGVRRRRGEL-----------------CLEVWDRGPGIPQDKQKVIFEEFkrldsH 971
Cdd:PRK13837  558 PAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLrapkvlshgvlppgryvLLRVSDTGAGIDEAVLPHIFEPF-----F 632

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  972 QTRAeKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLARTQVSAPAKPAQESGQPLS-GAQVLCVDNEESILI 1050
Cdd:PRK13837  633 TTRA-GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKVPVAPQAFFGPGPLPRGrGETVLLVEPDDATLE 711

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1051 GMRSLLTRWGCE-VWTARDQAQCAALLAEGVRPQLALVDYHLDHGEtgtELMGWLRAqLAEPIPGVVISADGRPEMVAQV 1129
Cdd:PRK13837  712 RYEEKLAALGYEpVGFSTLAAAIAWISKGPERFDLVLVDDRLLDEE---QAAAALHA-AAPTLPIILGGNSKTMALSPDL 787

                         330       340
                  ....*....|....*....|....*
gi 489307513 1130 HAAGLDYLAKPVKPAALRALLSRHL 1154
Cdd:PRK13837  788 LASVAEILAKPISSRTLAYALRTAL 812

SLC5sbd_PanF

cd10327

Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ...

12-502

1.12e-14

Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.

Pssm-ID: 212037 Cd Length: 472 Bit Score: 78.02 E-value: 1.12e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   12 ALAYMAIMFAIAFYGDRRHAP----------LPPR-MRAWVYSLSL-AVYCTSWTFFGAVGQAAEQ--LWAFLPIYLGPV 77
Cdd:cd10327     5 IIIYLVILLGIGFYARRSKKRrsgdfleeyfIGGRsMGGFVLAMTLvATYTSASSFIGGPGAAYKIglGWVLLAMIQVPT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   78 LLLVLApwVL-QKMVLISKQENITSIADFIAARYgKSQSLAVVVALICLVGVLPYIALQLKGivlGVNLLigasADTTGT 156
Cdd:cd10327    85 GFLTLG--VLgKKFAIIARKINAVTIIDYLRARY-NSKALVVLSSLALIVFFIAAMVAQFIG---GARLL----EAVTGL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  157 RSQDTALIVSLVLALFTIVFGTRNLDATEHHRGMVLAIAfeSLVKLFAFLAVGafvtyglyDGFDDLFSQ------AMLA 230
Cdd:cd10327   155 SYVTGLLIFGLTVILYTTIGGFRAVALTDAIQGIVMIIG--TVLLLVGVLAAG--------GGMEAIMATlaeidpNLLT 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  231 PRLEEYWketvNWP---SMVVQTGVammAIICLPRqfhvTVVENI---DPQDLRLAKWVfpAYLILAALFVIPIALG--G 302
Cdd:cd10327   225 PFGPGFL----SPPyilSFWVLVGF---GVIGLPQ----TAVRCMgykDSKSMHRAMII--GTVVVGFLMLGMHLAGvlG 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  303 KMLLPGSVLPDSYVISLPLAEAHPALAVLaFIGGASAAT-----GMVIVASialSTMVsNDMLLPWLLRRSSAERPfevf 377
Cdd:cd10327   292 RAVLPDLEVPDKVIPTLALKVLPPWLAGL-FLAGPLAAImstvdSQLILAS---SAIV-KDLYLNYKNKEKKTSEK---- 362

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  378 rhwmlSVRRVSIVIILLLAYVSYRL-LGSSASLATIGQIAFAA--VTQLAPAMLGaLYWKQANRRGVFAGLAAGTFLWFY 454
Cdd:cd10327   363 -----KVKRISLIITIILGLLVFLLaINPPDLIVWLNLFAFGGleAAFFWPLVLG-LYWKRANATGALASMVVGLVSYIL 436

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 489307513  455 TlvlpvtakslgwsfsLFPGMTWLHSHPLglsVTSLTLGTVFSLAGNF 502
Cdd:cd10327   437 I---------------TYLKIKILGLHPI---VPSLLLSLIAFIIVSL 466

HATPase_BaeS-like

cd16946

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

908-1014

1.84e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.

Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 70.57 E-value: 1.84e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  908 DIKLLRRVLQNFLTNAFRYAD--GPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAI 985
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTDtgGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80

                          90       100
                  ....*....|....*....|....*....
gi 489307513  986 ADGLCRVLGHRLSVRSWPGKGSVFSVRVP 1014
Cdd:cd16946    81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109

SLC5sbd_u4

cd11480

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...

102-473

3.22e-14

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.

Pssm-ID: 271374 Cd Length: 488 Bit Score: 76.77 E-value: 3.22e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  102 IADFIAARYGkSQSLAVVVALICLVGVLPYIALQLKGIVLGVNLLIGASadttgtrsQDTALIVSLVLALFTIVFGtrnl 181
Cdd:cd11480    98 VPDFLGARLG-SRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIP--------YEVGVVVVGALMIVYVVLG---- 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  182 datehhrGMvLAI----AFESLVKLFAFL--AVGAFVTYGLYDGFDDLF----SQAMLAPRLEEYWKETVNWPSM--VVQ 249
Cdd:cd11480   165 -------GM-RATtwvqIIQYVLLLGAFLvpAILVLARFGGNPLGAGPGllglAAAAASGAGEAYLAPGLLLTDPldVIS 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  250 TGVAMM-AIICLPrqfHV-----TVVeniDPQDLRL-AKWVF----------PAYLILAALFVIPIALGGKMLLPGSVLP 312
Cdd:cd11480   237 LTLALMlGTAGLP---HVlmrfyTVP---DARAARKsVVWALgfiglfyllaPALGFGARALVGPDVIGAPIAGELDGGG 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  313 DSYVISLPLAEAHPALaVLAFI-GGA-----SAATGMVIVASIALSTmvsnDmLLPWLLRRSSAERpFEVFrhwmlsVRR 386
Cdd:cd11480   311 DMAVLLLPEIAGLGDL-LLALVaAGAfaailATVAGLLLAAASALAH----D-LYAGVIRPGASER-REVR------VAR 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  387 VSIVIILLLAYvsyrLLGSSASLATIGQI---AFA-AVTQLAPAMLGALYWKQANRRGVFAGLAAGTFLWFYTLVL--PV 460
Cdd:cd11480   378 IAAVVVGVIAI----LLALLFPPQNVAFLvalAFAiAASAFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLVLIVLspAV 453

                         410
                  ....*....|...
gi 489307513  461 TAKSLGWSFSLFP 473
Cdd:cd11480   454 SGAPPGHDFAGFP 466

RpfG

COG3437

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...

1039-1156

8.92e-14

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];

Pssm-ID: 442663 [Multi-domain] Cd Length: 224 Bit Score: 71.73 E-value: 8.92e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLdHGETGTELMGWLRAQ-LAEPIPGVVI 1117
Cdd:COG3437     9 VLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEA-PPDLILLDVRM-PGMDGFELLRLLRADpSTRDIPVIFL 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 489307513 1118 SADGRPEMVAQVHAAG-LDYLAKPVKPAALRALLSRHLPL 1156
Cdd:COG3437    87 TALADPEDRERALEAGaDDYLTKPFDPEELLARVRNALEL 126

PleD

COG3706

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...

1039-1150

1.99e-13

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];

Pssm-ID: 442920 [Multi-domain] Cd Length: 179 Bit Score: 69.55 E-value: 1.99e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLDhGETGTELMGWLRAQLA-EPIPGVVI 1117
Cdd:COG3706     4 ILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEH-RPDLILLDLEMP-DMDGLELCRRLRADPRtADIPIIFL 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 489307513 1118 SADGRPEMVAQVHAAG-LDYLAKPVKPAALRALL 1150
Cdd:COG3706    82 TALDDEEDRARALEAGaDDYLTKPFDPEELLARV 115

PRK09835

Cu(+)/Ag(+) sensor histidine kinase;

775-1000

5.87e-13

Cu(+)/Ag(+) sensor histidine kinase;

Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 72.50 E-value: 5.87e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  775 ELSQLNVALTDAKGVAETASQSKTRFLAAVSHDLMQPL-NAARLFSAALSHqndgmSPDARQLVQHLDSSL----RSAEd 849
Cdd:PRK09835  240 ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPItNLITQTEIALSQ-----SRSQKELEDVLYSNLeeltRMAK- 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  850 LISDLLDISRLENGKINPQRQPFVLNELFDTLGAEFKALAQEQGLRFRLRGSRLRVDSDIKLLRRVLQNFLTNAFRYADG 929
Cdd:PRK09835  314 MVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPA 393

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489307513  930 PVLLGVRRRRGELCLEVWDRGPGIPQDKQKV--IFEEFKRLDSHQTRAEKGLGLGLAIADGLcrVLGHRLSVR 1000
Cdd:PRK09835  394 GEAITVRCQEVDHQVQLVVENPGTPIAPEHLprLFDRFYRVDPSRQRKGEGSGIGLAIVKSI--VVAHKGTVA 464

PRK10755

two-component system sensor histidine kinase PmrB;

767-985

1.70e-12

two-component system sensor histidine kinase PmrB;

Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 70.38 E-value: 1.70e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  767 QRVTERTHELSQLNVALTdakgvaeTASQSKTRFLAAVSHDLMQPLNAARLFSAALSHQNdgmSPDARQLVQHLDSSLRS 846
Cdd:PRK10755  114 LEIEAVTSALNQLVSRLT-------STLDQERLFTADVAHELRTPLAGIRLHLELLEKQH---HIDVAPLIARLDQMMHT 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  847 aedlISDLLDISRLENGKINPQRQPF-VLNELFDTLGAEFKALAQ--EQGLRFRLRGSRLRVDSDIKLLRRVLQNFLTNA 923
Cdd:PRK10755  184 ----VEQLLQLARAGQSFSSGHYQTVkLLEDVILPSQDELSEMLEqrQQTLLLPESAADITVQGDATLLRLLLRNLVENA 259

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489307513  924 FRYAD--GPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTraekGLGLGLAI 985
Cdd:PRK10755  260 HRYSPegSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSRYG----GIGLGLSI 319

COG4567

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...

1039-1153

1.73e-12

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];

Pssm-ID: 443624 [Multi-domain] Cd Length: 177 Bit Score: 66.86 E-value: 1.73e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQcAALLAEGVRPQLALVDYHLDhGETGTELMGWLRaQLAEPIPGVVIS 1118
Cdd:COG4567     7 LLLVDDDEAFARVLARALERRGFEVTTAASVEE-ALALLEQAPPDYAVLDLRLG-DGSGLDLIEALR-ERDPDARIVVLT 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 489307513 1119 ADGRPEM-VAQVHAAGLDYLAKPVKPAALRALLSRH 1153
Cdd:COG4567    84 GYASIATaVEAIKLGADDYLAKPADADDLLAALERA 119

phoR

PRK11006

phosphate regulon sensor histidine kinase PhoR;

800-1014

2.09e-12

phosphate regulon sensor histidine kinase PhoR;

Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 70.81 E-value: 2.09e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  800 FLAAVSHDLMQPLNAARLFsAALSHQNDGMSPDARQLVQHLDSSLRSAEDLISDLLDISRLENGkinPQRQpfvLNELFD 879
Cdd:PRK11006  207 FFANVSHELRTPLTVLQGY-LEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAA---PTID---LNEKVD 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  880 T------LGAEFKALAQEQ-GLRFRLrGSRLRVDSDIKLLRRVLQNFLTNAFRYADGPVLLGVRRRRGE--LCLEVWDRG 950
Cdd:PRK11006  280 VpmmlrvLEREAQTLSQGKhTITFEV-DNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPqgAEFSVEDNG 358

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489307513  951 PGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAIADglcRVLGH---RLSVRSWPGKGSVFSVRVP 1014
Cdd:PRK11006  359 PGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVK---HALSHhdsRLEIESEVGKGTRFSFVLP 422

OmpR

COG0745

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...

1037-1153

3.97e-12

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];

Pssm-ID: 440508 [Multi-domain] Cd Length: 204 Bit Score: 66.52 E-value: 3.97e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1037 AQVLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLdHGETGTELMGWLRAQLAEpIPGVV 1116
Cdd:COG0745     2 PRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEE-RPDLILLDLML-PGMDGLEVCRRLRARPSD-IPIIM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 489307513 1117 ISADGRPEMVAQVHAAG-LDYLAKPVKP----AALRALLSRH 1153
Cdd:COG0745    79 LTARDDEEDRVRGLEAGaDDYLTKPFDPeellARIRALLRRR 120

PRK10549

two-component system sensor histidine kinase BaeS;

768-985

4.14e-12

two-component system sensor histidine kinase BaeS;

Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 70.05 E-value: 4.14e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  768 RVTERTH-ELSQLNVALTDAKGVAETASQSKTRFLAAVSHDLMQPLNAARLFSAALshqNDGMspdaRQLVQHLDSSLRs 846
Cdd:PRK10549  210 RVTPTSRdELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAI---QDGV----RKFTPESVASLQ- 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  847 AE-----DLISDLLDISRLENGKINPQRQPFVLNELFDTLGAEFKALAQEQGLRFRLR-GSRLRVDSDIKLLRRVLQNFL 920
Cdd:PRK10549  282 AEvgtltKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSlPDSATVFGDPDRLMQLFNNLL 361

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489307513  921 TNAFRYAD--GPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAI 985
Cdd:PRK10549  362 ENSLRYTDsgGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAI 428

envZ

PRK09467

osmolarity sensor protein; Provisional

786-985

4.20e-12

osmolarity sensor protein; Provisional

Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 69.55 E-value: 4.20e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  786 AKGVAETAsQSKTRFLAAVSHDLMQPLNAARLFSaalshqnDGMSPDarqlvqhlDSSLrsAEDLISDLLD--------I 857
Cdd:PRK09467  219 AAGIKQLE-DDRTLLMAGVSHDLRTPLTRIRLAT-------EMMSEE--------DGYL--AESINKDIEEcnaiieqfI 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  858 SRLENGKiNPQRQPFVLNELF-DTLGAEFKalaQEQGLRFRLRGSRLRVDSDIKLLRRVLQNFLTNAFRYADG--PVLLG 934
Cdd:PRK09467  281 DYLRTGQ-EMPMEMADLNALLgEVIAAESG---YEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGwiKVSSG 356

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489307513  935 VRRRRGELCLEvwDRGPGIPQDKQKVIFEEFKRLDShqTRAEKGLGLGLAI 985
Cdd:PRK09467  357 TEGKRAWFQVE--DDGPGIPPEQLKHLFQPFTRGDS--ARGSSGTGLGLAI 403

HATPase_EnvZ-like

cd16950

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

912-1014

4.56e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.

Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 63.62 E-value: 4.56e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAFRYADGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDShqTRAEKGLGLGLAIADGLCR 991
Cdd:cd16950     1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDN--ARGTSGTGLGLAIVQRISD 78

                          90       100
                  ....*....|....*....|...
gi 489307513  992 VLGHRLSVRSWPGKGSVFSVRVP 1014
Cdd:cd16950    79 AHGGSLTLANRAGGGLCARIELP 101

REC_2_DhkD-like

cd17580

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...

1039-1150

4.61e-12

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381118 [Multi-domain] Cd Length: 112 Bit Score: 63.63 E-value: 4.61e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDqAQCAALLAEGVRPQLALVDYHLDhGETGTELMGWLRAQ-LAEPIPGVVI 1117
Cdd:cd17580     1 ILVVDDNEDAAEMLALLLELEGAEVTTAHS-GEEALEAAQRFRPDVILSDIGMP-GMDGYELARRLRELpWLANTPAIAL 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 489307513 1118 SADGRPEMVAQVHAAGLD-YLAKPVKPAALRALL 1150
Cdd:cd17580    79 TGYGQPEDRERALEAGFDaHLVKPVDPDELIELI 112

HisKA

pfam00512

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...

796-863

4.86e-12

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.

Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 62.23 E-value: 4.86e-12

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489307513   796 SKTRFLAAVSHDLMQPLNAARLFSAALshQNDGMSPDARQLVQHLDSSLRSAEDLISDLLDISRLENG 863
Cdd:pfam00512    1 AKSEFLANLSHELRTPLTAIRGYLELL--RDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66

HisKA

smart00388

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...

796-863

7.12e-12

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.

Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 61.81 E-value: 7.12e-12

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489307513    796 SKTRFLAAVSHDLMQPLNAARLFSAALshQNDGMSPDARQLVQHLDSSLRSAEDLISDLLDISRLENG 863
Cdd:smart00388    1 AKREFLANLSHELRTPLTAIRGYLELL--LDTELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66

cpxA

PRK09470

envelope stress sensor histidine kinase CpxA;

799-985

1.02e-11

envelope stress sensor histidine kinase CpxA;

Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 68.81 E-value: 1.02e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  799 RFLAAVSHDLMQPLNAARLFSAALSHQNdGMSPDarqlVQHLDSSLRSAEDLISDLLDISRLENgKINPQRQPFVLNELF 878
Cdd:PRK09470  245 RLLSDISHELRTPLTRLQLATALLRRRQ-GESKE----LERIETEAQRLDSMINDLLVLSRNQQ-KNHLERETFKANSLW 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  879 DTL--GAEFKALAQEQGLRFRLRGSRLRVDSDIKLLRRVLQNFLTNAFRYADGPVLLGVRRRRGELCLEVWDRGPGIPQD 956
Cdd:PRK09470  319 SEVleDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEE 398

                         170       180
                  ....*....|....*....|....*....
gi 489307513  957 KQKVIFEEFKRLDSHQTRAEKGLGLGLAI 985
Cdd:PRK09470  399 EREQIFRPFYRVDEARDRESGGTGLGLAI 427

Response_reg

pfam00072

Response regulator receiver domain; This domain receives the signal from the sensor partner in ...

1039-1150

1.10e-11

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.

Pssm-ID: 395025 [Multi-domain] Cd Length: 111 Bit Score: 62.55 E-value: 1.10e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLDhGETGTELMGWLRaQLAEPIPGVVIS 1118
Cdd:pfam00072    1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEE-RPDLILLDINMP-GMDGLELLKRIR-RRDPTTPVIILT 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 489307513  1119 ADGRPEMVAQVHAAG-LDYLAKPVKPAALRALL 1150
Cdd:pfam00072   78 AHGDEDDAVEALEAGaDDFLSKPFDPDELLAAI 110

HisKA

cd00082

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...

794-859

1.59e-11

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.

Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 60.69 E-value: 1.59e-11

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489307513  794 SQSKTRFLAAVSHDLMQPLNAARLFSAALSHQNDGmSPDARQLVQHLDSSLRSAEDLISDLLDISR 859
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLD-DEEQREYLERIREEAERLLRLINDLLDLSR 65

HATPase_PhoQ-like

cd16954

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

915-1012

2.14e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.

Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 62.65 E-value: 2.14e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  915 VLQNFLTNAFRYADGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLD-SHQtraekGLGLGLAIADGLCRVL 993
Cdd:cd16954    41 LLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDeQRP-----GQGLGLAIAKEIVEQY 115

                          90
                  ....*....|....*....
gi 489307513  994 GHRLSVRSWPGKGSVFSVR 1012
Cdd:cd16954   116 GGELSLSDSPLGGARFEVV 134

ComP

COG4585

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

806-1018

2.44e-11

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 65.41 E-value: 2.44e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  806 HD-LMQPLNAARLFSAALSHQNDGMSPDARQLVQHLDSSLRSAedlISDLLDISRLENGKINPQRqpfvlnELFDTLGAE 884
Cdd:COG4585    62 HDgVGQSLSAIKLQLEAARRLLDADPEAAREELEEIRELAREA---LAELRRLVRGLRPPALDDL------GLAAALEEL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  885 FKALAQEQGLRFRLR--GSRLRVDSDIKL-LRRVLQNFLTNAFRYADG-PVLLGVRRRRGELCLEVWDRGPGIPQDkqkv 960
Cdd:COG4585   133 AERLLRAAGIRVELDvdGDPDRLPPEVELaLYRIVQEALTNALKHAGAtRVTVTLEVDDGELTLTVRDDGVGFDPE---- 208

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 489307513  961 ifeefkrldshqtrAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLART 1018
Cdd:COG4585   209 --------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252

KinA

COG5805

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...

629-1015

3.35e-11

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 67.06 E-value: 3.35e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  629 EVLQFNRALLQGAIENITQGISVVDQSLRLVAWNRRYLELFNYPEGLIsVGRPIADIIRY-NAERglcgPGEAEVHVARR 707
Cdd:COG5805   150 EILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREEL-IGKNLLELLHPcDKEE----FKERIESITEV 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  708 lhwmRQGRAHTSERLFPNGRVI--ELIGNPMPGG-----GFVMSFTDITAFREAEQALteanegleqRVTERthelsqLN 780
Cdd:COG5805   225 ----WQEFIIEREIITKDGRIRyfEAVIVPLIDTdgsvkGILVILRDITEKKEAEELM---------ARSEK------LS 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  781 VALTDAKGVAetasqsktrflaavsHDLMQPLNAAR----LFSAALSHQNDGMspdarqlvQHLDSSLRSAEDLISDLLD 856
Cdd:COG5805   286 IAGQLAAGIA---------------HEIRNPLTSIKgflqLLQPGIEDKEEYF--------DIMLSELDRIESIISEFLA 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  857 ISRLENgkinPQRQPFVLNELFDTLGA--EFKALAQEQGLRFRLRGSRLRVDSDIKLLRRVLQNFLTNAFRYAD--GPVL 932
Cdd:COG5805   343 LAKPQA----VNKEKENINELIQDVVTllETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPngGTIT 418

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  933 LGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFkrldshQTRAEKGLGLGLA----IADglcrvlGHR--LSVRSWPGKG 1006
Cdd:COG5805   419 IHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPF------FTTKEKGTGLGLMvsykIIE------NHNgtIDIDSKVGKG 486


                  ....*....
gi 489307513 1007 SVFSVRVPL 1015
Cdd:COG5805   487 TTFTITLPL 495

REC_hyHK_CKI1_RcsC-like

cd17546

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...

1039-1150

4.75e-11

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381099 [Multi-domain] Cd Length: 113 Bit Score: 60.95 E-value: 4.75e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYH---LDhgetGTELMGWLRAQ--LAEPIP 1113
Cdd:cd17546     1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEE-PFDLVLMDLQmpvMD----GLEATRRIRELegGGRRTP 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489307513 1114 GVVISADGRPEMVAQVHAAGLD-YLAKPVKPAALRALL 1150
Cdd:cd17546    76 IIALTANALEEDREKCLEAGMDdYLSKPVKLDQLKEVL 113

HATPase_Glnl-NtrB-like

cd16918

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

912-1014

6.33e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).

Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 60.49 E-value: 6.33e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAFRYADGP-------------VLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFkrldshQTRAEKG 978
Cdd:cd16918     1 LIQVFLNLVRNAAQALAGSggeiilrtrtqrqVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPM------VSGRENG 74

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 489307513  979 LGLGLAIADGLCRVLGHRLSVRSWPGKgSVFSVRVP 1014
Cdd:cd16918    75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109

HATPase_EcPhoR-like

cd16952

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

912-1017

1.09e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.

Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 59.91 E-value: 1.09e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAFRYADGPVLLGVRRRRGE--LCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAIADgl 989
Cdd:cd16952     1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEEsgARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVK-- 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 489307513  990 cRVLGH---RLSVRSWPGKGSVFSVRVPLAR 1017
Cdd:cd16952    79 -HVMSRhdaRLLIASELGKGSRFTCLFPSSR 108

HATPase_HupT_MifS-like

cd16976

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

912-1011

1.41e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.

Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 59.39 E-value: 1.41e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAF----RYADGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFkrldsHQTR-AEKGLGLGLAIA 986
Cdd:cd16976     1 IQQVLMNLLQNALdamgKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPF-----FTTKpVGKGTGLGLSIS 75

                          90       100
                  ....*....|....*....|....*
gi 489307513  987 DGLCRVLGHRLSVRSWPGKGSVFSV 1011
Cdd:cd16976    76 YGIVEEHGGRLSVANEEGAGARFTF 100

PRK10618

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional

795-1066

1.69e-10

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional

Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 65.34 E-value: 1.69e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  795 QSKTRFLAAVSHDLMQPLNAARLFSAALSH--QNDGMSPDARQLVQHLDSSLRsaedLISDLLDISRLENGKINPQRQPF 872
Cdd:PRK10618  448 QARKAFLQNIGDELKQPLQSLAQLAAQLRQtsDEEQQQPELDQLAEQSDVLVR----LVDNIQLLNMLETQDWKPEQELF 523

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  873 VLNELFDTLGAEFKALAQEQGL----RFRLRGSRLRVdSDIKLLRRVLQNFLTNAFRYAD-GPVLLGVRR---RRGELCL 944
Cdd:PRK10618  524 SLQDLIDEVLPEVLPAIKRKGLqlliHNHLKAEQLRI-GDRDALRKILLLLLNYAITTTAyGKITLEVDQdesSPDRLTI 602

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  945 EVWDRGPGIPQDKQKVIfeEFKRL-DSHQTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLartqvsAP 1023
Cdd:PRK10618  603 RILDTGAGVSIKELDNL--HFPFLnQTQGDRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKM------LA 674

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 489307513 1024 AKPAQESGQP--LSGAQVLC-VDNEE--SILIGMrslLTRWGCEVWTA 1066
Cdd:PRK10618  675 ADPEVEEEEEklLDGVTVLLdITSEEvrKIVTRQ---LENWGATCITP 719

PAS

COG2202

PAS domain [Signal transduction mechanisms];

626-801

1.91e-10

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 62.73 E-value: 1.91e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  626 EASEVLQFNRALLQGAIENITQGISVVDQSLRLVAWNRRYLELFNYPEGLIsVGRPIADIIrynaerglcGPGEAEVHVA 705
Cdd:COG2202     1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEEL-LGKTLRDLL---------PPEDDDEFLE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  706 RRLHWMRQGRAHTSERLF--PNGRVI--ELIGNPMPGG-----GFVMSFTDITAFREAEQALTEANEGLEQRVterthEL 776
Cdd:COG2202    71 LLRAALAGGGVWRGELRNrrKDGSLFwvELSISPVRDEdgeitGFVGIARDITERKRAEEALRESEERLRLLV-----EN 145

                         170       180
                  ....*....|....*....|....*
gi 489307513  777 SQLNVALTDAKGVAETASQSKTRFL 801
Cdd:COG2202   146 APDGIFVLDLDGRILYVNPAAEELL 170

COG3920

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...

550-1019

6.00e-10

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];

Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 63.00 E-value: 6.00e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  550 LAARFVGEERAHQSFVRFAYRQGKGFNPNQNADNDWIAHTERLLAGVLGASSTRAVVKAAIEGREMQLEDVVRIADEASE 629
Cdd:COG3920    82 LALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  630 VLQFNRALLqgAIENITQGISVVDQSLRLVAWNRRYLELFNYPEGLISVGRPIADIIRYNAERGLCGPGEAEVHVARRLH 709
Cdd:COG3920   162 LLAEELAAL--RLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLE 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  710 WMRQGRAHTSERLFPNGRVIELIGNPMPGGGFVMSFTDITAFREAEQALTEANEglEQRVTerTHELS-------QLNVA 782
Cdd:COG3920   240 ELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLE--EKELL--LRELHhrvknnlQVVSS 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  783 LtdakgVAETASQSKTRFLAAVSHDLMQplnaaRLFSAALSHqndgmspdaRQLVQHLDSSlrsaedlisdlldisrlen 862
Cdd:COG3920   316 L-----LRLQARRADDPEAREALEESQN-----RIQALALVH---------ELLYQSEDWE------------------- 357

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  863 gKINpqrqpfvLNELFDTLGAEFKALAQEQGLRFRLRGSRLRVDSDIKL-LRRVLQNFLTNAFRYA-----DGPVLLGVR 936
Cdd:COG3920   358 -GVD-------LRDYLRELLEPLRDSYGGRGIRIELDGPDVELPADAAVpLGLILNELVTNALKHAflsgeGGRIRVSWR 429

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  937 RRRGELCLEVWDRGPGIPQDkqkvifeefkrldshqTRAEKGLGLGLAIADGLCRVLGHRLSVRSwpGKGSVFSVRVPLA 1016
Cdd:COG3920   430 REDGRLRLTVSDNGVGLPED----------------VDPPARKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITFPLA 491


                  ...
gi 489307513 1017 RTQ 1019
Cdd:COG3920   492 ELA 494

HATPase_DpiB-CitA-like

cd16915

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

915-1014

6.58e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.

Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 57.30 E-value: 6.58e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  915 VLQNFLTNAF------RYADGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEfkrldSHQTRAEKGLGLGLAIADG 988
Cdd:cd16915     4 IVGNLIDNALdalaatGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFER-----GVSTKGQGERGIGLALVRQ 78

                          90       100
                  ....*....|....*....|....*.
gi 489307513  989 LCRVLGHRLSVRSWPGKGSVFSVRVP 1014
Cdd:cd16915    79 SVERLGGSITVESEPGGGTTFSIRIP 104

HATPase_BasS-like

cd16940

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

911-1012

6.60e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.

Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 57.80 E-value: 6.60e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  911 LLRRVLQNFLTNAFRY--ADGPVLLGVRRRRGELcLEVWDRGPGIPQDKQKVIFEEFKRLDShqtRAEKGLGLGLAIADG 988
Cdd:cd16940    13 LLFLLLRNLVDNAVRYspQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIVKR 88

                          90       100
                  ....*....|....*....|....
gi 489307513  989 LCRVLGHRLSVRSWPGKGSVFSVR 1012
Cdd:cd16940    89 IVELHGGQIFLGNAQGGGLEAWVR 112

HATPase_FilI-like

cd16921

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

912-1014

1.08e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 56.95 E-value: 1.08e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAFRYA---DGPVL-LGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLdsHQTRAEKGLGLGLAIAD 987
Cdd:cd16921     1 LGQVLTNLLGNAIKFRrprRPPRIeVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRL--HSREEYEGTGVGLAIVR 78

                          90       100
                  ....*....|....*....|....*..
gi 489307513  988 GLCRVLGHRLSVRSWPGKGSVFSVRVP 1014
Cdd:cd16921    79 KIIERHGGRIWLESEPGEGTTFYFTLP 105

HATPase_AtoS-like

cd16943

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

911-1015

3.72e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.

Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 55.12 E-value: 3.72e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  911 LLRRVLQNFLTNAFRYAD--GPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFkrldsHQTRAE-KGLGLGLAIAD 987
Cdd:cd16943     3 QLNQVLLNLLVNAAQAMEgrGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPF-----FTTKPVgEGTGLGLSLSY 77

                          90       100
                  ....*....|....*....|....*...
gi 489307513  988 GLCRVLGHRLSVRSWPGKGSVFSVRVPL 1015
Cdd:cd16943    78 RIIQKHGGTIRVASVPGGGTRFTIILPI 105

HATPase_BceS-YxdK-YvcQ-like

cd16948

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

907-1014

4.94e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.

Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 54.98 E-value: 4.94e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  907 SDIKLLRRVLQNFLTNAFRYAD--GPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEF-----KRLDSHQTraekgl 979
Cdd:cd16948     1 TDAKWLSFIIGQIVSNALKYSKqgGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGftgenGRNFQEST------ 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 489307513  980 GLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVP 1014
Cdd:cd16948    75 GMGLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109

HATPase_TmoS-FixL-DctS-like

cd16920

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

940-1014

7.36e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 54.32 E-value: 7.36e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489307513  940 GELCLEVWDRGPGIPQDKQKVIFEEFkrldsHQTRAEkGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVP 1014
Cdd:cd16920    36 RAVTISVKDTGPGIAEEVAGQLFDPF-----YTTKSE-GLGMGLSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104

SSF

pfam00474

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...

36-448

7.41e-09

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.

Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 59.28 E-value: 7.41e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513    36 RMRAWVYSLSLAV-YCTSWTFFGAVGQAAEQLWAFLPIYLGPVLLLVLAPWVLQKmvlISKQENITSIADFIAARYGKSQ 114
Cdd:pfam00474    7 SMTGFVNGLSLAAsYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAP---RLRNLGAYTMPDYLRKRFGGKR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   115 SLAVVVALICLVGVLPYIALQLKGIVLGVNLLIGASADTTgtrsqdtALIVSLVLALFTIVFGTRNLDATEHHRGMVLAI 194
Cdd:pfam00474   84 ILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTA-------VLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLF 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   195 AfESLVKLFAFLAVGafvtyglydGFDDLFSQAMLA-PRLEEYWK------------ETVNWPSMVV-QTGVAMMAIICL 260
Cdd:pfam00474  157 G-TIILMIIVFHEVG---------GYSSAVEKYMTAdPNGVDLYTpdglhilrdpltGLSLWPGLVLgTTGLPHILQRCL 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   261 PRQFHVTVVENIdpqdlRLAKWVFPAYLILAalfvIPIALGGKMLLpgSVLPDSYVISLPLAE-AHPALAV-------LA 332
Cdd:pfam00474  227 AAKDAKCIRCGV-----LILTPMFIIVMPGM----ISRGLFAIALA--GANPRACGTVVGCSNiAYPTLAVklgppglAG 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   333 FIGGASAATGMVIVASIAL--STMVSNDMLLpwLLRRSSAERPFEVFRhwmlsvrrVSIVIILLLAYVSYRLLGSSASLA 410
Cdd:pfam00474  296 IMLAVMLAAIMSTLTSQLLssSSAFTHDLYK--NIRRKASATEKELVG--------RSRIIVLVVISLAILLAVQPAQMG 365

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 489307513   411 TIGQIAFA---AVTQLAPAMLGALYWKQANRRGVFAGLAAG 448
Cdd:pfam00474  366 IAFLVQLAfagLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406

PRK10337

sensor protein QseC; Provisional

799-1012

1.39e-08

sensor protein QseC; Provisional

Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 58.51 E-value: 1.39e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  799 RFLAAVSHDLMQPLNAARLFS--AALSHQNDGMSPDArqlVQHLDSSLRSAEDLISDLLDISRLENGKINPQRQPFVLNE 876
Cdd:PRK10337  239 RFTSDAAHELRSPLAALKVQTevAQLSDDDPQARKKA---LLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLED 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  877 LFDTLGAEFKALAQEQGLRFRLRGSrlrvDSDIK------LLRRVLQNFLTNAFRYAdgPVLLGVRRRRGELCLEVWDRG 950
Cdd:PRK10337  316 LLQSAVMDIYHTAQQAGIDVRLTLN----AHPVIrtgqplLLSLLVRNLLDNAIRYS--PQGSVVDVTLNARNFTVRDNG 389

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489307513  951 PGIPQDKQKVIFEEFKRLDSHQtraEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVR 1012
Cdd:PRK10337  390 PGVTPEALARIGERFYRPPGQE---ATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448

HATPase_VanS-like

cd16923

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

912-1014

1.58e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.

Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 53.54 E-value: 1.58e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAFRYADGPVLLGVRRRRGELCLEVWDRGPG--IPQDKQKVIFEEFKRLDShqTRAEKGLGLGLAIADGL 989
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSshPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAI 78

                          90       100
                  ....*....|....*....|....*
gi 489307513  990 CRVLGHRLSVRSwPGKGSVFSVRVP 1014
Cdd:cd16923    79 IELHGGSASAEY-DDNHDLFKVRLP 102

AmiR

COG3707

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...

1039-1150

2.49e-08

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];

Pssm-ID: 442921 [Multi-domain] Cd Length: 194 Bit Score: 55.35 E-value: 2.49e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGVRPQLALVDYHLDhGETGTELMGWLRAQLAEPIpgVVIS 1118
Cdd:COG3707     6 VLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMP-DRDGLEAARQISEERPAPV--ILLT 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 489307513 1119 ADGRPEMVAQVHAAGLD-YLAKPVKPAALRALL 1150
Cdd:COG3707    83 AYSDPELIERALEAGVSaYLVKPLDPEDLLPAL 115

sensory_box

TIGR00229

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

641-758

2.69e-08

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 53.45 E-value: 2.69e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   641 AIENITQGISVVDQSLRLVAWNRRYLELFNY-PEGLIsvGRPIADIIRynaerglcgPGEAEVHVAR-RLHWMRQGRAHT 718
Cdd:TIGR00229    8 IFESSPDAIIVIDLEGNILYVNPAFEEIFGYsAEELI--GRNVLELIP---------EEDREEVRERiERRLEGEPEPVS 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 489307513   719 SERLFP--NGRVI--ELIGNPMP--GG--GFVMSFTDITAFREAEQAL 758
Cdd:TIGR00229   77 EERRVRrkDGSEIwvEVSVSPIRtnGGelGVVGIVRDITERKEAEEAL 124

REC_RpfG-like

cd17551

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...

1037-1148

3.46e-08

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381103 [Multi-domain] Cd Length: 118 Bit Score: 52.83 E-value: 3.46e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1037 AQVLCVDNEESILIGMRSLLTRWG-CEVWTARDqAQCAALLAEGVRPQLALVDY---HLDhgetGTELMGWLRAQLA-EP 1111
Cdd:cd17551     1 MRILIVDDNPTNLLLLEALLRSAGyLEVVSFTD-PREALAWCRENPPDLILLDYmmpGMD----GLEFIRRLRALPGlED 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489307513 1112 IPGVVISADGRPEMVAQVHAAGL-DYLAKPVKPAALRA 1148
Cdd:cd17551    76 VPIVMITADTDREVRLRALEAGAtDFLTKPFDPVELLA 113

PRK10364

two-component system sensor histidine kinase ZraS;

802-1019

1.22e-07

two-component system sensor histidine kinase ZraS;

Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 55.56 E-value: 1.22e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  802 AAVSHDLMQPLNAARLFSAALSHQNDGMSpDARQLVQHLDSSLRSAEDLISDLLDISRlengkinPQR---QPFVLNELF 878
Cdd:PRK10364  242 AGVAHEIRNPLSSIKGLAKYFAERAPAGG-EAHQLAQVMAKEADRLNRVVSELLELVK-------PTHlalQAVDLNDLI 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  879 DTLGAEFKALAQEQG--LRFRLRGSRLRVDSDIKLLRRVLQNFLTNAFRY--ADGPVLLGVRRRRGELCLEVWDRGPGIP 954
Cdd:PRK10364  314 NHSLQLVSQDANSREiqLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAigQHGVISVTASESGAGVKISVTDSGKGIA 393

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489307513  955 QDKQKVIFeefkrlDSHQTRAEKGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLARTQ 1019
Cdd:PRK10364  394 ADQLEAIF------TPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITR 452

HATPase_CreC-like

cd16945

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

911-1006

1.28e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.

Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 50.92 E-value: 1.28e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  911 LLRRVLQNFLTNA--FRYADGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTrAEKGLGLGLAIADG 988
Cdd:cd16945     4 LLRQAINNLLDNAidFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHS-GQKSTGLGLAFVQE 82

                          90
                  ....*....|....*...
gi 489307513  989 LCRVLGHRLSVRSWPGKG 1006
Cdd:cd16945    83 VAQLHGGRITLRNRPDGV 100

RocR

COG3829

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

631-775

1.50e-07

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 55.16 E-value: 1.50e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  631 LQFNRALLQGAIENITQGISVVDQSLRLVAWNRRYLELFNYPEGLIsVGRPIADIIRynaerglcgpgeaEVHVARRLhw 710
Cdd:COG3829     6 LKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEV-IGKNVTELIP-------------NSPLLEVL-- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489307513  711 mRQGRAHTSERLFPNGRVIELIGNPMP---GG---GFVMSFTDITAFREAEQALtEANEGLEQRVTERTHE 775
Cdd:COG3829    70 -KTGKPVTGVIQKTGGKGKTVIVTAIPifeDGeviGAVETFRDITELKRLERKL-REEELERGLSAKYTFD 138

SLC5sbd_CHT

cd11474

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...

98-491

1.62e-07

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.

Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 55.22 E-value: 1.62e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   98 NITSIADFIAARYGKSqsLAVVVALICLVGVLPYIALQLK--GIVLGVnlligasadTTGTrSQDTALIVSLVLALFTIV 175
Cdd:cd11474    95 GLLTLGDFFRQRYGRR--VEVLLSIPAVLSYLGWVAAQLValGLVLSV---------ILGL-PVETGILISAAIVLAYTL 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  176 FGtrnldatehhrGMvLAIAFESLVKLFaFLAVGAFV----TYGLYDGFDDLFSQAMLAPRL---EEYWKETVNWpsmvv 248
Cdd:cd11474   163 FG-----------GM-WSVAYTDVVQLI-VIFVGLLVlvpfVLTNPGGVDIASAAAAGKLRFfpwLGTKSDWLIW----- 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  249 qtgVAMMAIICLprqfhvtvvENIDPQDL----------RLAKW--VFPA--YLILAALFVIpIALGGKMLLPGSV---L 311
Cdd:cd11474   225 ---IDAWLTLGL---------GSIPQQDVfqrvlsakseKTAQRlsLLAGvgYLLFAIPPLL-IGLAAASIDPSLTqygL 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  312 PDSYVISLPLAEAH---PALAVLaFIGGASAATGMVIVASI-ALSTMVSNDmLLPWLLRRSSAERPfevfrhwMLSVRRV 387
Cdd:cd11474   292 EEDAQLILPLLLQYltpLWVQVL-FLGALLSAVMSTADSALlAPSSVFSEN-IYKPPFRPKASDRE-------LLWVMRI 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  388 SIVIILLLAYV-------SYRLLGSSASLATIGqiafaAVTQLapamLGALYWKQANRRGVFAGLAAGTFLWFYTLVLPV 460
Cdd:cd11474   363 SVVVFGAIATLmaltvesIYGLVELASDLVLVG-----LFVPL----LAGLYWKRANTYGALAAIIVGLVLRLLGGELLL 433

                         410       420       430
                  ....*....|....*....|....*....|..
gi 489307513  461 TAKSLGWS-FSLFPGMTwlhshpLGLSVTSLT 491
Cdd:cd11474   434 GLPADIPPqLQGFPFST------LAMVIGSLL 459

sss

TIGR00813

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...

36-448

2.18e-07

Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 54.62 E-value: 2.18e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513    36 RMRAWVYSLSL-AVYCTSWTFFGAVGQAAEQLWAFLPIYLGPVLLLVLAPWVLqkmVLISKQENITSIADFIAARYGKS- 113
Cdd:TIGR00813    4 SLGGWVVAASLfASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLF---VPIFINNGAYTMPEYLEKRFGKRi 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   114 -QSLAVVVALICLVGvlpYIALQLKGIVLGVNLLIGASADTTgtrsqdtALIVSLVLALFTIVFGTRnldatehhrGMVL 192
Cdd:TIGR00813   81 lRGLSVLSLILYIFL---YMSVDLFSGALLIELITGLDLYLS-------LLLLGAITILYTVFGGLK---------AVVW 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   193 AIAFESLVKLFAFLAVGAFVTY--GLYDGFDDLFSQAMLAPRLEEYWKETVNWPS---MVVQTGVAMMAIICLPRQF-HV 266
Cdd:TIGR00813  142 TDTIQAVIMILGTFILPVFAFSevGGLGTFVEKASQAAPTNPSPDDLYDFFRDPStsdLPWGAGVFGLPHVALWYWTnQV 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   267 TVVENIDPQDLRLAKwvfpAYLILAA-LFVIPIALggkMLLPG--------SVLPDSYVISLPLAE-AHPALAVL---AF 333
Cdd:TIGR00813  222 IVQRCLAAKSAKHAK----KGCLISGvLKLLPMFG---AVLPGliaralytDIDPALAGAVNQNSDqAYPLLVQElmpPG 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   334 IGGASAATGMVIVAS------IALSTMVSNDMLLPWllRRSSAERpfevfRHWMLSVRRVSIVIILLLAYVsyrllgssA 407
Cdd:TIGR00813  295 LAGLFLAAILAAVMStlssqlNSASTVFTMDLYKKI--IRPNASG-----EKKIVMRGRIAVLVAAVIAGF--------V 359

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 489307513   408 SLATIGQIAFAAVT-------QLAPAMLGALYWKQANRRGVFAGLAAG 448
Cdd:TIGR00813  360 AAAQGGQVLQYVQEafgglgaPFLPVFLLGIFWKRMNAKGALAGMIAG 407

YesM

COG2972

Sensor histidine kinase YesM [Signal transduction mechanisms];

847-1015

2.78e-07

Sensor histidine kinase YesM [Signal transduction mechanisms];

Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 54.25 E-value: 2.78e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  847 AEDLISDLLDISR--LENGKinpqrqpfvlneLFDTLGAEFKA----LAQEQgLRFrlrGSRLRVDSDI-------KLLR 913
Cdd:COG2972   275 AEEMLEALSKLLRysLSKGD------------ELVTLEEELELiksyLEIQK-LRF---GDRLEVEIEIdeelldlLIPK 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  914 RVLQNFLTNAFRYA------DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKrldshqtRAEKGLGLGLAIAD 987
Cdd:COG2972   339 LILQPLVENAIEHGiepkegGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELS-------SKGEGRGIGLRNVR 411

                         170       180       190
                  ....*....|....*....|....*....|.
gi 489307513  988 ---GLCRVLGHRLSVRSWPGKGSVFSVRVPL 1015
Cdd:COG2972   412 erlKLYYGEEYGLEIESEPGEGTTVTIRIPL 442

HATPase_UhpB-NarQ-NarX-like

cd16917

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

912-1014

2.80e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.

Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 49.47 E-value: 2.80e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAFRYADGP-VLLGVRRRRGELCLEVWDRGPGIPQDkqkvifeefkrldshqtRAEKGLGLGLAIADGLC 990
Cdd:cd16917     1 LYRIVQEALTNALKHAGASrVRVTLSYTADELTLTVVDDGVGFDGP-----------------APPGGGGFGLLGMRERA 63

                          90       100
                  ....*....|....*....|....
gi 489307513  991 RVLGHRLSVRSWPGKGSVFSVRVP 1014
Cdd:cd16917    64 ELLGGTLTIGSRPGGGTRVTARLP 87

PRK11086

sensory histidine kinase DcuS; Provisional

915-1014

3.41e-07

sensory histidine kinase DcuS; Provisional

Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 54.53 E-value: 3.41e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  915 VLQNFLTNAFRYA----DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEfkrldSHQTRAEkGLGLGLAIADGLC 990
Cdd:PRK11086  437 ILGNLIENALEAVggeeGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDK-----GYSTKGS-NRGVGLYLVKQSV 510

                          90       100
                  ....*....|....*....|....
gi 489307513  991 RVLGHRLSVRSWPGKGSVFSVRVP 1014
Cdd:PRK11086  511 ENLGGSIAVESEPGVGTQFFVQIP 534

HATPase_CckA-like

cd16919

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...

942-1014

8.40e-07

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).

Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 48.92 E-value: 8.40e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489307513  942 LCLEVWDRGPGIPQDKQKVIFEEFkrldsHQTRAE-KGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVP 1014
Cdd:cd16919    48 VCLEVSDTGSGMPAEVLRRAFEPF-----FTTKEVgKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116

RsbW

COG2172

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];

920-1015

1.00e-06

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];

Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 49.14 E-value: 1.00e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  920 LTNAFRYA-----DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEfkrldshqtraEKGLGLGLAIADGLCrvlg 994
Cdd:COG2172    43 VTNAVRHAyggdpDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYST-----------LAEGGRGLFLIRRLM---- 107

                          90       100
                  ....*....|....*....|.
gi 489307513  995 HRLSVRSWPGkGSVFSVRVPL 1015
Cdd:COG2172   108 DEVEYESDPG-GTTVRLVKRL 127

PAS

COG2202

PAS domain [Signal transduction mechanisms];

626-758

1.01e-06

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 51.56 E-value: 1.01e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  626 EASEVLQFNRALLQGAIENITQGISVVDQSLRLVAWNRRYLELFNYPEGLIsVGRPIADIIRYNAERglcgpgEAEVHVA 705
Cdd:COG2202   127 RAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEEL-LGKSLLDLLHPEDRE------RLLELLR 199

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 489307513  706 RRLHWMRQGRAHTSERLFPNGRVIELIGNPMP------GGGFVMSFTDITAFREAEQAL 758
Cdd:COG2202   200 RLLEGGRESYELELRLKDGDGRWVWVEASAVPlrdggeVIGVLGIVRDITERKRAEEAL 258

REC_typeB_ARR-like

cd17584

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...

1039-1154

1.83e-06

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381121 [Multi-domain] Cd Length: 115 Bit Score: 48.01 E-value: 1.83e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEgvRPQ---LALVDYHLDHGEtGTELMGWLRAQLAepIPGV 1115
Cdd:cd17584     1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLRE--NKDefdLVITDVHMPDMD-GFEFLELIRLEMD--LPVI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 489307513 1116 VISADGRPEMVAQVHAAG-LDYLAKPVKPAALRAlLSRHL 1154
Cdd:cd17584    76 MMSADGSTSTVMKGLAHGaCDYLLKPVSIEDLKN-IWQHV 114

REC_CheC-like

cd17593

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...

1052-1153

3.38e-06

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381124 [Multi-domain] Cd Length: 117 Bit Score: 47.15 E-value: 3.38e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1052 MRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYhldhgeTGTELMGW--LRAQLAEPIPG--VVISADGRPEMVA 1127
Cdd:cd17593    17 ARALPADWDVEITFAENGEEALEILREG-RIDVLFLDL------TMPVMDGYevLEALPVEQLETkvIVVSGDVQPEAKE 89

                          90       100
                  ....*....|....*....|....*..
gi 489307513 1128 QVHAAG-LDYLAKPVKPAALRALLSRH 1153
Cdd:cd17593    90 RVLELGaLAFLKKPFDPEKLAQLLEEL 116

HATPase_SpaK_NisK-like

cd16975

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

908-999

4.70e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.

Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 46.69 E-value: 4.70e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  908 DIKLLRRVLQNFLTNAFRYA--DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQtRAEKGLGLGLAI 985
Cdd:cd16975     1 DTLLLSRALINIISNACQYApeGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79

                          90
                  ....*....|....
gi 489307513  986 ADGLCRVLGHRLSV 999
Cdd:cd16975    80 AKNLVEKHGGSLII 93

REC_D1_PleD-like

cd17538

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...

1039-1141

1.55e-05

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381093 [Multi-domain] Cd Length: 104 Bit Score: 44.80 E-value: 1.55e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDY---HLDhgetGTELMGWLRAQLAEP-IPG 1114
Cdd:cd17538     2 ILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEE-LPDLILLDVmmpGMD----GFEVCRRLKEDPETRhIPV 76

                          90       100
                  ....*....|....*....|....*...
gi 489307513 1115 VVISA-DGRPEMVAQVHAAGLDYLAKPV 1141
Cdd:cd17538    77 IMITAlDDREDRIRGLEAGADDFLSKPI 104

PRK10815

two-component system sensor histidine kinase PhoQ;

915-986

1.65e-05

two-component system sensor histidine kinase PhoQ;

Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 48.86 E-value: 1.65e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489307513  915 VLQNFLTNAFRYADGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTraekGLGLGLAIA 986
Cdd:PRK10815  382 VMGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVA 449

HATPase_NtrY-like

cd16944

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

908-1014

3.45e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.

Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 44.07 E-value: 3.45e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  908 DIKLLRRVLQNFLTNAFRYA----DGPVLLGVR---RRRGELCLEVWDRGPGIPQDKQKVIFEefkrldSHQTRAEKGLG 980
Cdd:cd16944     1 DTTQISQVLTNILKNAAEAIegrpSDVGEVRIRveaDQDGRIVLIVCDNGKGFPREMRHRATE------PYVTTRPKGTG 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 489307513  981 LGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVP 1014
Cdd:cd16944    75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108

SLC5sbd_DUR3

cd11476

Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ...

51-474

4.21e-05

Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.

Pssm-ID: 271370 Cd Length: 493 Bit Score: 47.58 E-value: 4.21e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   51 TSWTFFGAVGQAAE---------QLWAFLPIylgpVLLLVLAPWVLQKMvliskqENITSIADFIAARYGKSQSLavVVA 121
Cdd:cd11476    57 WAATLLQSATVAYQygvsgpfwyASGATLQI----LLFAPLAIRIKRLA------PNAHTLLEIVRARYGTAAHL--VFL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  122 LICLVGVLPYIALQLKGIVLGVNLLigasadtTGTRSQDTALIVSLVLALFTIVFGTRnldATehhrgmVLAIAFESLVk 201
Cdd:cd11476   125 VFALFTNVIVLAMLLLGGSAVVNAL-------TGMPIVAASFLIPLGVLLYTLFGGLR---AT------FLTDYIHTVI- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  202 LFAFLAVGAFVTY------GLYDGFDDLFS-QAMLAPRLEEYWKETVNWPSMVVQTGVAMMAIiclprqFHVTVVENIDP 274
Cdd:cd11476   188 ILIILLVFAFAVYtssdigSPSKVYDLLQEaAPDLPVEGNQGSYLTFKSKAGLIFGIINIVGN------FGTVFLDQGYW 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  275 QDLRLAK--WVFPAYLILA-ALFVIPIALGGKMLLpGSVLPDSYVISLPLAEAHPALAVLAFIGGASAATGMVI-----V 346
Cdd:cd11476   262 QRAIAARpsAAVKGYFLGGlAWFAIPFLLATTLGL-AALALGLNPTFEEVSAGLVLPYVAAALLGKGGAAAVLVllfmaV 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  347 AS------IALSTMVSNDMLLPWLLRRSSAERpfevfrhwMLSVRRVSIVIILLLAYV-SYRLLGSSASLATIGQIAFAA 419
Cdd:cd11476   341 TStasaelIAVSSIVTYDIYRTYINPNATGKQ--------LLRVSRIAVIGFGLFMGGlAVGLNYIGISLGWLLLFMGIL 412

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489307513  420 VTQLAPAMLGALYWKQANRRGVF----AGLAAGTFLWF---YTLVLPVTAKSLGWSFSLFPG 474
Cdd:cd11476   413 IGSAVFPVALGLYWRRQTGTAAVvspiAGLVAGLAVWLvtaKSYYGEVNVDTTGGNYPMLAG 474

PRK13435

response regulator; Provisional

1039-1152

1.51e-04

response regulator; Provisional

Pssm-ID: 184052 [Multi-domain] Cd Length: 145 Bit Score: 43.12 E-value: 1.51e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGVRPQLALVDYHLDHGETGTElmgwLRAQLAEPIPGVVIS 1118
Cdd:PRK13435    8 VLIVEDEALIALELEKLVEEAGHEVVGIAMSSEQAIALGRRRQPDVALVDVHLADGPTGVE----VARRLSADGGVEVVF 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 489307513 1119 ADGRPEMVAQVHAAGLDYLAKPVKPAALRALLSR 1152
Cdd:PRK13435   84 MTGNPERVPHDFAGALGVIAKPYSPRGVARALSY 117

REC_PhyR

cd17540

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...

1037-1151

1.55e-04

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381095 [Multi-domain] Cd Length: 117 Bit Score: 42.24 E-value: 1.55e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1037 AQVLCVDNEESILIGMRSLLTRWGCEV-WTARDQAQCAALLAEgVRPQLALVDYHLDHGETGTELMgwLRAQLAEPIPGV 1115
Cdd:cd17540     1 TRVLIIEDEPLIAMDLEQIVEDLGHQVvGIARTRDEAVALARR-ERPDLILADIQLADGSSGIDAV--NEILTTHDVPVI 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 489307513 1116 VISAdgRPEMVAQVHAAGLDYL-AKPVKPAALRALLS 1151
Cdd:cd17540    78 FVTA--YPERLLTGERPEPTFLiTKPFDPEMVKAAIS 112

REC_PilR

cd19926

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...

1039-1140

2.06e-04

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381153 [Multi-domain] Cd Length: 100 Bit Score: 41.75 E-value: 2.06e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLDHGeTGTELMGWLRAQLAEpIPGVVIS 1118
Cdd:cd19926     1 VLVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASE-PYDLCLTDMRLPDG-SGLELVQHIQQRLPQ-TPVAVIT 77

                          90       100
                  ....*....|....*....|...
gi 489307513 1119 ADGRPEM-VAQVHAAGLDYLAKP 1140
Cdd:cd19926    78 AYGSLDTaIEALKAGAFDFLTKP 100

COG4192

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...

760-997

2.33e-04

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];

Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 45.45 E-value: 2.33e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  760 EANEGLEQRVTERTHELSQLNVALTDAKGVAETASQSKTrfLAAVSHDLMQPLNAAR--LFSAALSHQNDGMSpDARQLV 837
Cdd:COG4192   398 EKTQELETEIEERKRIEKNLRQTQDELIQAAKMAVVGQT--MTSLAHELNQPLNAMSmyLFSAKKALEQENYA-QLPTSL 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  838 QHLDSSLRSAEDLISDLLDISRLENGKInpqrQPFVLNELFDTLGAEFKALAQEQGLRFRLRGSrLRVDSDIKLLRRVLQ 917
Cdd:COG4192   475 DKIEGLIERMDKIIKSLRQFSRKSDTPL----QPVDLRQVIEQAWELVESRAKPQQITLHIPDD-LMVQGDQVLLEQVLV 549

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  918 NFLTNAFRYADGPVLLGVR--RRRGELCLEVWDRGPGIP-QDKqkvIFEEFkrldshQTRAEKGLGLGLAIadglCRVLG 994
Cdd:COG4192   550 NLLVNALDAVATQPQISVDllSNAENLRVAISDNGNGWPlVDK---LFTPF------TTTKEVGLGLGLSI----CRSIM 616


                  ...
gi 489307513  995 HRL 997
Cdd:COG4192   617 QQF 619

PAS

smart00091

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

636-686

3.14e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 40.08 E-value: 3.14e-04

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 489307513    636 ALLQGAIENITQGISVVDQSLRLVAWNRRYLELFNYPEGLIsVGRPIADII 686
Cdd:smart00091    1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEEL-IGKSLLELI 50

REC_OmpR_PhoB

cd17618

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...

1037-1152

4.16e-04

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381133 [Multi-domain] Cd Length: 118 Bit Score: 41.08 E-value: 4.16e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1037 AQVLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEgVRPQLALVDYHLDhGETGTELMGWLRAQ-LAEPIPGV 1115
Cdd:cd17618     1 RTILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVE-PRPDLILLDWMLP-GGSGIQFIRRLKRDeMTRDIPII 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 489307513 1116 VISADGRPE-MVAQVHAAGLDYLAKPVKPaalRALLSR 1152
Cdd:cd17618    79 MLTARGEEEdKVRGLEAGADDYITKPFSP---RELVAR 113

REC_TPR

cd17589

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...

1039-1147

4.70e-04

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.

Pssm-ID: 381123 [Multi-domain] Cd Length: 115 Bit Score: 41.09 E-value: 4.70e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGVRPQLALVDYHLDHGETGTELMGWLR-AQLAEPIPGVV- 1116
Cdd:cd17589     1 FLIVDDQPTFRSMLKSMLRSLGVTRIDTASSGEEALRMCENKTYDIVLCDYNLGKGKNGQQLLEELRhKKLISPSTVFIm 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 489307513 1117 ISADGRPEMVaqVHAAGL---DYLAKPVKPAALR 1147
Cdd:cd17589    81 VTGESSRAMV--LSALELepdDYLLKPFTVSELR 112

HATPase_BvrS-ChvG-like

cd16953

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

912-1014

4.88e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.

Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 41.02 E-value: 4.88e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  912 LRRVLQNFLTNAFRYA-DGPVLLGVRRRRG--ELCLEVWDRGPGIPQDKQKVIFEEFKRLDSHQTRAEKGLGLGLAIADG 988
Cdd:cd16953     1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTgkMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 489307513  989 LCRVLGHRL--SVRSWPG--KGSVFSVRVP 1014
Cdd:cd16953    81 IIEAHGGISvaENHNQPGqvIGARFTVQLP 110

REC_OmpR_VirG

cd17594

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...

1039-1152

5.62e-04

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381125 [Multi-domain] Cd Length: 113 Bit Score: 40.89 E-value: 5.62e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEesilIGMRSLLTRW----GCEVWTARDQAQCAALLAEGvRPQLALVDYHLdHGETGTELMGWLRAQLAEPIpg 1114
Cdd:cd17594     2 VLVVDDD----AAMRHLLILYlrerGFDVTAAADGAEEARLMLHR-RVDLVLLDLRL-GQESGLDLLRTIRARSDVPI-- 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 489307513 1115 VVISADGRPEM--VAQVHAAGLDYLAKPVkpaALRALLSR 1152
Cdd:cd17594    74 IIISGDRRDEIdrVVGLELGADDYLAKPF---GLRELLAR 110

SLC5sbd_SGLT5

cd11489

Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ...

79-458

7.70e-04

Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.

Pssm-ID: 212058 Cd Length: 604 Bit Score: 43.77 E-value: 7.70e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   79 LLVLApWVLqkmVLISKQENITSIADFIAARYGKSQSLAVVVALICLVGVLPYIALQLKGIVLGVNLLIGASADTTgtrs 158
Cdd:cd11489    85 LLALA-WVF---VPVYISSGIVTMPEYLQRRFGGERIRMYLSVLSLLLSVFTKISTDLYSGALFVQVCLGWNLYLS---- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  159 qdtALIVSLVLALFTIVFGTRNLDATEHHRGMVLAIAFeslvklfAFLAVGAFVTYGLYDGFDDLFSQAMLA-------- 230
Cdd:cd11489   157 ---TVLMLVVTALYTIAGGLAAVIYTDALQTLIMVIGA-------VILTIKAFNQIGGYSNLEEAYLQAVPSkiipnttc 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  231 --PRLE--EYWKETVN----WPSMVVqtGVAMMAII--CLPRqfhVTVVENIDPQDLRLAKW--VFPAYLILAALFVIpi 298
Cdd:cd11489   227 hlPRADamHLFRDPVTgdlpWTGMTF--GLTIMATWywCTDQ---VIVQRSLSARSLSHAKGgsILASYLKMLPMGLI-- 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  299 alggkmLLPGSV----LPDSYVISLPL-------AE------AHPALAV-LAFIG--GASAATGMVIVASIALSTMVSND 358
Cdd:cd11489   300 ------IMPGMIsralFPDDVACVDPEeclrvcgAEvgcsniAYPKLVMeLMPSGlrGLMIAVMMAALMSSLTSIFNSSS 373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  359 MLLP---WL-LRRSSAERPfevfrhwMLSVRRVSIVIILLLAYVSYRLLGSSASlatiGQ--IAFAAVTQ-LAPAMLG-- 429
Cdd:cd11489   374 TLFTmdiWRrLRPGASERE-------LLLVGRLVTVILVGVSVVWIPILQSSNS----GQlyIYIQSVTSyLAPPVTAvf 442

                         410       420       430
                  ....*....|....*....|....*....|.
gi 489307513  430 --ALYWKQANRRGVFAGLAAGTFLWFYTLVL 458
Cdd:cd11489   443 vlAVFWRRANEQGAFWGLMAGLVVGLTRMVL 473

REC_HupR-like

cd17569

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...

1039-1150

1.01e-03

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381113 [Multi-domain] Cd Length: 118 Bit Score: 40.08 E-value: 1.01e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGvRPQLALVDYHLDhGETGTELMGWLRAQLAEPI------ 1112
Cdd:cd17569     3 ILLVDDEPNILKALKRLLRREGYEVLTATSGEEALEILKQE-PVDVVISDQRMP-GMDGAELLKRVRERYPDTVrilltg 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 489307513 1113 ---PGVVISADGRpemvAQVHAagldYLAKPVKPAALRALL 1150
Cdd:cd17569    81 yadLDAAIEAINE----GEIYR----FLTKPWDDEELKETI 113

HATPase_CheA-like

cd16916

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...

868-1014

1.15e-03

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.

Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 41.03 E-value: 1.15e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  868 QRQPFVLNELFDTLGAEfkalaqeqgLRFRLRGSRLRVDSD-IKLLRRVLQNFLTNAFRY--------------ADGPVL 932
Cdd:cd16916     3 SRFPRLVRDLARELGKQ---------VELVVEGEDTELDKSvLEKLADPLTHLLRNAVDHgieapeerlaagkpPEGTIT 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  933 LGVRRRRGELCLEVWDRGPGIPQDK--QKVI------FEEFKRLDSHQ-----------TRAE----KGLGLGLAIADGL 989
Cdd:cd16916    74 LRAEHQGNQVVIEVSDDGRGIDREKirEKAIerglitADEAATLSDDEvlnlifapgfsTAEQvtdvSGRGVGMDVVKRS 153

                         170       180
                  ....*....|....*....|....*
gi 489307513  990 CRVLGHRLSVRSWPGKGSVFSVRVP 1014
Cdd:cd16916   154 IESLGGTIEVESEPGQGTTFTIRLP 178

PRK13557

histidine kinase; Provisional

741-1150

1.22e-03

histidine kinase; Provisional

Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 42.74 E-value: 1.22e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  741 FVMSFTDITAFREAEQALTEAnegleqrvtERTHELSQLNvaltdakgvaetasqsktrflAAVSHD---LMQPLNA-AR 816
Cdd:PRK13557  137 FFGSQLDVSRRRDAEDALRQA---------QKMEALGQLT---------------------GGIAHDfnnLLQVMSGyLD 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  817 LFSAALSHQnDGMSPDARQLVQHLDSSLRSAEDLISDLLDISR---LENGKINpqrqpfvLNELFD--------TLGaef 885
Cdd:PRK13557  187 VIQAALSHP-DADRGRMARSVENIRAAAERAATLTQQLLAFARkqrLEGRVLN-------LNGLVSgmgelaerTLG--- 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  886 KALAQEQGLRFRLRGSRL-RVDSDIKLLrrvlqNFLTNAfRYA--DGPVLLgVRRRRGEL-----------------CLE 945
Cdd:PRK13557  256 DAVTIETDLAPDLWNCRIdPTQAEVALL-----NVLINA-RDAmpEGGRVT-IRTRNVEIededlamyhglppgryvSIA 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  946 VWDRGPGIPQDKQKVIFEEFkrldsHQTRAE-KGLGLGLAIADGLCRVLGHRLSVRSWPGKGSVFSVRVPLARTQVSAPA 1024
Cdd:PRK13557  329 VTDTGSGMPPEILARVMDPF-----FTTKEEgKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQAENPEQ 403

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1025 KPAQESGQPLSGAQVLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEGVRPQLALVDYHLDHGETGTELMGWL 1104
Cdd:PRK13557  404 EPKARAIDRGGTETILIVDDRPDVAELARMILEDFGYRTLVASNGREALEILDSHPEVDLLFTDLIMPGGMNGVMLAREA 483

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489307513 1105 RAQLaepiPGV-VISADGRPEMVAQVHAAG---LDYLAKPVKPAAL----RALL 1150
Cdd:PRK13557  484 RRRQ----PKIkVLLTTGYAEASIERTDAGgseFDILNKPYRRAELarrvRMVL 533

HATPase_RsbW-like

cd16936

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...

920-991

1.43e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.

Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 38.79 E-value: 1.43e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489307513  920 LTNAFRYA-----DGPVLLGVRRRRGELCLEVWDRGPGIPQdkqkvifeefkRLDSHQTRAEKGLGLGLAIADGLCR 991
Cdd:cd16936     9 VTNAVRHAyrhdgPGPVRLELDLDPDRLRVEVTDSGPGFDP-----------LRPADPDAGLREGGRGLALIRALMD 74

PRK10529

DNA-binding transcriptional activator KdpE; Provisional

1037-1153

1.55e-03

DNA-binding transcriptional activator KdpE; Provisional

Pssm-ID: 182522 [Multi-domain] Cd Length: 225 Bit Score: 41.33 E-value: 1.55e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1037 AQVLCVDNEESILIGMRSLLTRWGCEVWTArDQAQCAALLAEGVRPQLALVDYHLDHGEtGTELMGWLRAQLAepIPGVV 1116
Cdd:PRK10529    2 TNVLIVEDEQAIRRFLRTALEGDGMRVFEA-ETLQRGLLEAATRKPDLIILDLGLPDGD-GIEFIRDLRQWSA--IPVIV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 489307513 1117 ISA-DGRPEMVAQVHAAGLDYLAKPVK----PAALRALLSRH 1153
Cdd:PRK10529   78 LSArSEESDKIAALDAGADDYLSKPFGigelQARLRVALRRH 119

SLC5sbd_NIS-like_u2

cd11494

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...

36-497

1.88e-03

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.

Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 42.20 E-value: 1.88e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   36 RMRAWVYSLS-LAVYCTSWTFFGAVGQAAEQLWAFLPIYLG-P----VLLLVLAPwVLQKMvliskqeNITSIADFIAAR 109
Cdd:cd11494    36 SMPWWPIGLSiMATQASAITFLSAPGQAYSDGMRFVQYYFGlPlamiFLCITFVP-VFYKL-------KVYTAYEYLERR 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  110 YG-KSQSLAVVVALI--CL-VGVLPY-IALQLKGIvLGVNLLIgasadttgtrsqdTALIVSLVLALFTIVFGTrnldat 184
Cdd:cd11494   108 FGlKTRLLTSILFLIsrGLaTGVTIYaPAIILSTI-LGWSLWL-------------TILLIGGITIIYTVLGGI------ 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  185 ehhRGMVLAIAFESLVKLFAFLAVGAFVTYGLYDGFDDLFSQAMLAPRL-----EEYWKETVNWPSMVVqtGVAMMAIic 259
Cdd:cd11494   168 ---KAVIWTDVIQMVIIWAGLFIAFGLLLKLLPVGFVDALLVAGKSGRLnaldfSFDLSDTYTFWSGLI--GGFFLYL-- 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  260 lpRQFHV--TVVENI----DPQDLRLAkwvfpayLILAALFVIPIALGgkMLLPGSVL--------PDSYVISLPLAEAH 325
Cdd:cd11494   241 --SYFGTdqSQVQRYltakSIKEARKS-------LLLNGFLKFPMQFF--ILLIGVLVfvfyqfnpFPVSFNPAEDETKD 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  326 PALAVLAFIGGA--SAATGMVIVAsIALSTMVSNDMLLPWL--------LRRSSaeRPFEVFRHWmLSVRRVSIVIILLL 395
Cdd:cd11494   310 TNYIFLRFVLNYlpPGVIGLLIAA-IFAAAMSSIDSALNSLatvtvidiYRRFF--KKDASDEHY-LKVSRLLTVFWGLL 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513  396 AYVSYRLLGSSASL----ATIGQIAFAAVtqLAPAMLgALYWKQANRRGVFAGLAAGTFLWFYtlvlpvtakslgwsFSL 471
Cdd:cd11494   386 AIVFALFAGLAGSLieavNKLGSLFYGPI--LGVFLL-AFFTKKANGKGVFAGAILGVIVVIV--------------LWL 448

                         490       500
                  ....*....|....*....|....*.
gi 489307513  472 FPGMTWLHSHPLGLSVTsLTLGTVFS 497
Cdd:cd11494   449 FPDVSWLWWNVIGCVVV-IGVALLLS 473

REC_DC-like

cd17534

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...

1037-1148

2.47e-03

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381089 [Multi-domain] Cd Length: 117 Bit Score: 38.93 E-value: 2.47e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1037 AQVLCVDNEESILIGMRSLLTRWGCEVW-TARDqAQCAALLAEGVRPQLALVDYHLDHGETGTELMGWLRAQLaePIPGV 1115
Cdd:cd17534     1 KKILIVEDEAIIALDLKEILESLGYEVVgIADS-GEEAIELAEENKPDLILMDINLKGDMDGIEAAREIREKF--DIPVI 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 489307513 1116 VISADGRPEMV---AQVHAAGldYLAKPVKPAALRA 1148
Cdd:cd17534    78 FLTAYSDEETLeraKETNPYG--YLVKPFNERELKA 111

PAS

pfam00989

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

636-748

5.02e-03

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 38.17 E-value: 5.02e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513   636 ALLQGAIENITQGISVVDQSLRLVAWNRRYLELFNYPEGLIsVGRPIADIIrynaerglcgPGEAEVHVARRLHWMRQGR 715
Cdd:pfam00989    1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEV-IGKSLLDLI----------PEEDDAEVAELLRQALLQG 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 489307513   716 AHTSE----RLFPNGRVIELIGNPMP----GG---GFVMSFTDI 748
Cdd:pfam00989   70 EESRGfevsFRVPDGRPRHVEVRASPvrdaGGeilGFLGVLRDI 113

HATPase_c_2

pfam13581

Histidine kinase-like ATPase domain;

920-983

5.37e-03

Histidine kinase-like ATPase domain;

Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 38.42 E-value: 5.37e-03

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489307513   920 LTNAFRYA-----DGPVLLGVRRRRGELCLEVWDRGPGIPQDKQKvifeEFKRLDSHQTRAEKGLGLGL 983
Cdd:pfam13581   40 CTNAVEHAyregpEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLP----PPDLEEPDEDRKEGGRGLAL 104

REC_citrate_TCS

cd19925

phosphoacceptor receiver (REC) domain of citrate family two-component system response ...

1065-1152

5.40e-03

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381152 [Multi-domain] Cd Length: 118 Bit Score: 37.99 E-value: 5.40e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1065 TARDQAQCAALLAEgVRPQLALVDYHLDhGETGTELMGWLRAQlAEPIPGVVISADGRPEMV-AQVHAAGLDYLAKPVKP 1143
Cdd:cd19925    31 TAGTGEEALKLLKE-RQPDLILLDIYLP-DGNGLDLLRELRAA-GHDVDVIVVTAANDVETVrEALRLGVVDYLIKPFTF 107


                  ....*....
gi 489307513 1144 AALRALLSR 1152
Cdd:cd19925   108 ERLRQRLER 116

REC_NtrX-like

cd17550

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...

1039-1142

8.29e-03

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

Pssm-ID: 381102 [Multi-domain] Cd Length: 115 Bit Score: 37.48 E-value: 8.29e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489307513 1039 VLCVDNEESILIGMRSLLTRWGCEVWTARDQAQCAALLAEgVRPQLALVDYHLDhGETGTELMGWLRAQLAEpIPGVVIS 1118
Cdd:cd17550     1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKE-RRPDLVLLDIWLP-DMDGLELLKEIKEKYPD-LPVIMIS 77

                          90       100
                  ....*....|....*....|....*
gi 489307513 1119 ADGRPEM-VAQVHAAGLDYLAKPVK 1142
Cdd:cd17550    78 GHGTIETaVKATKLGAYDFIEKPLS 102

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01