|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-386 |
1.19e-72 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 231.28 E-value: 1.19e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 22 AMAVGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATA 101
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 102 FTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAI 181
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 182 ALCTIALVWQFVPD---RHDEPRSDPRKELRAFTKPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGLAA 258
Cdd:cd17324 163 ALLAALLLWRLLPSlppKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 259 FGVGGIIGNIAGGKLFDRLQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAP-LQIRLMDIAHEAPSL 337
Cdd:cd17324 243 FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSaLQTRVLRLAPEARGL 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489311504 338 AAASNHAAFNLANALGPWFGGMAITAGyGWTSTGYIGAATALVGLGIYL 386
Cdd:cd17324 323 ASSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLAL 370
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
22-393 |
4.97e-65 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 211.87 E-value: 4.97e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 22 AMAVGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATA 101
Cdd:PRK10091 7 SLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 102 FTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAI 181
Cdd:PRK10091 87 LSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 182 ALCTIALVWQFVPDRHDEPRSDPRKELRAFTKPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGLAAFGV 261
Cdd:PRK10091 167 NIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMMLVGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 262 GGIIGNIAGGKLFDRLQFRAVGWI--MVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAPLQIRLMDIAHEAPSLAA 339
Cdd:PRK10091 247 GMVLGNLLSGRLSGRYSPLRIAAVtdFIIVLALLMLFFFGGMKTASLIFAFICCAGLFALSAPLQILLLQNAKGGELLGA 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 489311504 340 ASNHAAFNLANALGPWFGGMAITAGYGWTSTGYIGAATALVGLGIYLIARRMKG 393
Cdd:PRK10091 327 AGGQIAFNLGSAIGAYCGGMMLTLGLAYNYVALPAALLSFAAMSSLLLYGRYKR 380
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-352 |
2.77e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 132.79 E-value: 2.77e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 12 PARSAAKMEAAMAVGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMG 91
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 92 LYALGNLATAFTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGW 171
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 172 RSAFALVSAIALCTIALVWQFVPDRHDEPRSDPRKELRA-FTKPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQ 250
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRElLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 251 WIPFGLAAFGVGGIIGNIAGGKLFDRLQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAP-LQIRLMD 329
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPlLQALVAE 323
|
330 340
....*....|....*....|....
gi 489311504 330 IAH-EAPSLAAASNHAAFNLANAL 352
Cdd:COG2814 324 LAPpEARGRASGLYNSAFFLGGPL 347
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
22-390 |
9.04e-27 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 109.98 E-value: 9.04e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 22 AMAVGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATA 101
Cdd:PRK03545 13 TLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLSA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 102 FTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAI 181
Cdd:PRK03545 93 LAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 182 ALCTIALVWQFVPDRHDEPRSDPRKELRAFTKPQ-VWMALsIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGLAAFG 260
Cdd:PRK03545 173 ALITLLLLIKLLPLLPSEHSGSLKSLPLLFRRPAlVSLYL-LTVVVVTAHFTAYSYIEPFVQQVAGLSENFATLLLLLFG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 261 VGGIIGNIAGGKLFDRLQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGT-MIAMAAPLQIRLMDIAHEAPSLAA 339
Cdd:PRK03545 252 GAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIaIMCIGLAMQVKVLKLAPDATDVAM 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 489311504 340 ASNHAAFNLANALGPWFGGMAITAgYGWTSTGYIGAATALVGLGIYLIARR 390
Cdd:PRK03545 332 ALFSGIFNIGIGAGALLGNQVSLH-LGLSSIGYVGAALALAALVWSILIFR 381
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-389 |
2.51e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 97.26 E-value: 2.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 24 AVGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFT 103
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 104 PTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIAL 183
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 184 CTIALVWQFVPDRHDEPRSDPRKELRAFT-------KPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGL 256
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKRAVSAARLRSglrlllrDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 257 AAFGVGGIIGNIAGGKLFDRLQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMA-APLQIRLMDIAHEAP 335
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVfPATLALLADIVPPEG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 489311504 336 -SLAAASNHAAFNLANALGPWFGGMaITAGYGWTSTGYIGAATALVGLGIYLIAR 389
Cdd:cd17325 322 rGTAMGLFNTAFSLGMVLGPLLGGF-LYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-390 |
1.21e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 89.55 E-value: 1.21e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 22 AMAVGAFAIGTGEFAIMG-LMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLAT 100
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSvLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 101 AFTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSA 180
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 181 IALCTIALVWQFVPDRHDEPRSDPRKELR----AFTKPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGL 256
Cdd:COG2223 168 LLLVVAVLAWLFLRDPPAGAAAAAKASLRdqleALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 257 AAFGVGGIIGNIAGGKLFDRLQFRAVGWIMVWSMAV-LIFFTFAASSLWGVLLGIGLVGTMIAMAAPLQIRLmdIAHEAP 335
Cdd:COG2223 248 ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALgLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFAL--VPDIFP 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 489311504 336 SLAAASNH----AAFNLANALGPWFGGMAITAGYGWTSTGYIGAATALVGLGIYLIARR 390
Cdd:COG2223 326 TKNAGAVYglvgAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-353 |
8.09e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 83.62 E-value: 8.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 23 MAVGAFAIGTGEFAIMGLMP-DIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATA 101
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 102 FTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAI 181
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 182 ALCTIALVWQFVPDRHDEPRSDPRKELRAFTKP------QVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFG 255
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAwkallrDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 256 LAAFGVGGIIGNIAGGKLFDRLQFR---AVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAPLQIRLmdIAH 332
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL--VSD 318
|
330 340
....*....|....*....|.
gi 489311504 333 EAPSLAAASNHAAFNLANALG 353
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLG 339
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-390 |
3.92e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 76.06 E-value: 3.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 21 AAMAVGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLAT 100
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 101 AFTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSA 180
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 181 IALCTIALvwqfvpdrhdeprsdprkelraftkpQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGLAAFG 260
Cdd:COG2271 173 PGLLLALL--------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 261 VGGIIGNIAGGKLFDRLQFR---AVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAPLQIRLMDIAH-EAPS 336
Cdd:COG2271 227 LAGIVGSLLGGWLSDRLGRRrklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARG 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 489311504 337 LAAASNHAAFNLANALGPWFGGMAITAgYGWTSTGYIGAATALVGLGIYLIARR 390
Cdd:COG2271 307 TASGLVNTFGFLGGALGPLLVGYLLDA-TGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
40-387 |
4.04e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 72.99 E-value: 4.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 40 LMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFISGLP 119
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 120 HGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVWQFVpdrhde 199
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 200 prsdprkelraftkPQVWMaLSIGAIGFAGMFCVFSYLAPTML-EVTKVSPQWIPFGLAAFGVGGIIGNIAGGKLFDRLQ 278
Cdd:cd17319 179 --------------RQVWG-LALGYFGINYALYGLLTWLPTYLkQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 279 FRAVGWIMVWSMAVLIFFTFAA---SSLWGVLLGIGLVGTMIAMAAPLQIRLMDIAHEAPSLAAAS--NHAAFNLANALG 353
Cdd:cd17319 244 RGARRLVIIIGLLLAAVGLLLAyltTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGglINSGGNLGGFVA 323
|
330 340 350
....*....|....*....|....*....|....
gi 489311504 354 PWFGGMAITAGYGWTSTGYIGAATALVGLGIYLI 387
Cdd:cd17319 324 PLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
23-386 |
4.08e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 73.23 E-value: 4.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 23 MAVGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAF 102
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 103 TPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQH--FGWRSAFALVSA 180
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 181 IALCTIALVWQFVPDRHDEPRSDPRKELRAFTKPQVWMALSIGAIGFAGMFCVF---------SYLAPTMLEVTKVSPQW 251
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLvnlayysfsTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 252 IPFGLAAFGVGGIIGNIAGGKLFDRLQFR-AVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAPLQIRLMDI 330
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRkPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489311504 331 AHEAPSLAAAS--NHAAFNLANALGPWFGGMAITAGYGWTSTGYIGAATALVGLGIYL 386
Cdd:cd06174 321 LFPPEIRGTAFglLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
42-387 |
1.35e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 71.45 E-value: 1.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 42 PDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFISGLPHG 121
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 122 AYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQhFGWRSAFALVSAIALCTIALVWQFVPDRHDEPR 201
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPEPKEKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 202 SDPRKELRAFTKPQVW-MALSIGAIGFAGMFCVFSYLA--PTMLE-VTKVSPQWIPFGLAAFGVGGIIGNIAGGKLFD-R 276
Cdd:cd17474 182 SSSATKLRDLKKALRGrGLLTFLVSAFLYFFLYFAFLTylPFLLElLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 277 LQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAPL-QIRLMDIAHEAP-SLAAASNHAAFNLANALGP 354
Cdd:cd17474 262 FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLlTTLVTELAPEEErGTASSLYNFVRFLGQAVGP 341
|
330 340 350
....*....|....*....|....*....|...
gi 489311504 355 WFGGMaITAGYGWTSTGYIGAATALVGLGIYLI 387
Cdd:cd17474 342 LLFGL-LLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
24-388 |
3.04e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 70.30 E-value: 3.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 24 AVGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFT 103
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 104 PTFGSLVAFRFISGLPhGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIAL 183
Cdd:cd17504 82 PNLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 184 CTIALVwqfvpdrhdeprsdPRKELRAFTKPQVWMALSIGAIGFAGMFCVFsYLAPTMLEvtkvSPQWIPFGLAA----- 258
Cdd:cd17504 161 LLAALV--------------PLIDLRLLRRRNVLLANITALLAGFGMFMVF-QLLPQLLQ----LPTPTGFGLGIteagl 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 259 ----FGVGGIIGNIAGGKLFDRLQFRAVGWI-MVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAPLQIRLMDIAHE 333
Cdd:cd17504 222 lllpGALVMLIAGPLAGRLIARVGPRRVLLIgLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489311504 334 A--PSLAAASNHAAFNLANALGPWFGGMAITAGYGWTSTGYIGAATA-----LVGLGIYLIA 388
Cdd:cd17504 302 PdrTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGVPTEGAyvlafLIGAALALAA 363
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-390 |
6.84e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 69.52 E-value: 6.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 1 MTIQQTPGHVLPARSAAKMEAAMAVGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKL 80
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 81 LRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPnDKRAGAVARVMMGLTLAMLLGNP 160
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 161 IATFLGQHFGWRSAFALVSAIALCTIALVWQFVPDRHDEPR--SDPRKELRAFTKPQVWMALSIGAIGFAGMFCVFSYLa 238
Cdd:COG2807 160 LTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAaaPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWL- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 239 PTMLEVTKVSPQWIPFGLAAFGVGGIIGNIAGGKLFDRLQFR-----AVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLV 313
Cdd:COG2807 239 PPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRrplllLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489311504 314 GTmIAMAAPLQIRLMDIAHEAPSLAAASNhAAFNLANALGPWFGGMAITAGYGWTSTGYIGAATALVGLGIYLIARR 390
Cdd:COG2807 319 GL-FPLALTLIGLRARTPAEAAALSGMAQ-SVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
28-389 |
9.54e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 68.77 E-value: 9.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 28 FAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFG 107
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 108 SLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIA 187
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 188 LVWqFVPDRHDEPRSDPRKELRAFTKPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGLAAFGVGGIIGN 267
Cdd:cd17489 166 LVF-LVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLLSR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 268 IAGGKLFDRLQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAP-LQIRLMDIA-HEAPSLAAASNHAA 345
Cdd:cd17489 245 PFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPaLQALAVDLVpPHRRGAANGTFFIF 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 489311504 346 FNLANALGPWFGGMaITAGYGWTSTGYIGAATALVGLGIYLIAR 389
Cdd:cd17489 325 FDLGIGLGGLLLGL-VAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
41-387 |
2.28e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 67.60 E-value: 2.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 41 MPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFISGLPH 120
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 121 GAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVWQFVP------ 194
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPetlpee 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 195 DRHDEPRSDPRKELRAFTKPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGLAAFGVGGIIGNIAGGKLF 274
Cdd:cd17320 182 KRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 275 DRLQFRAVGWIMVWSMAVLIFFTFAAS-----SLWGVLLGIGLVGTMIAMAAPLQIRL-MDIAHEAPSLAAASNHAAFNL 348
Cdd:cd17320 262 RRFGPRRLLRLGLLLLLAAALVLLLAAllgglSLWPLVAPLFLIFFGFGLIFPNATSLaLEPFPHVAGTASALLGFLQFL 341
|
330 340 350
....*....|....*....|....*....|....*....
gi 489311504 349 ANALGPWFGGMAItAGYGWTSTGYIGAATALVGLGIYLI 387
Cdd:cd17320 342 IGALAGALVGLLP-NGTALPMGLLILVLGLLALLLLILL 379
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
34-195 |
5.95e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 66.61 E-value: 5.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 34 EFAIMGLM-PDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAF 112
Cdd:TIGR00895 32 DLAAMGFAaPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLIL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 113 RFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVWQF 192
Cdd:TIGR00895 112 RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRF 191
|
...
gi 489311504 193 VPD 195
Cdd:TIGR00895 192 LPE 194
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
23-389 |
1.58e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 65.29 E-value: 1.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 23 MAVGAFAIGTGeFAIMGLMPDIA-HNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATA 101
Cdd:cd17473 5 LLASTLTVMAG-AAIAPALPAIAqHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 102 FTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRagavARVMMGLTLAMLLGNPIATFLGQH---FGWRSAFaLV 178
Cdd:cd17473 84 FLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEER----AKMLGLQSAAMSLGGVVFLLLGGAlaeIGWRAPF-LV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 179 SAIALCTIALVWQFVPD---RHDEPRSDPRKELRAFTKPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFG 255
Cdd:cd17473 159 YLLALPVLILVLLFLPEparKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 256 LAAFGVGGIIGNIAGGKLFDRLQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAP-LQIRLMDIAHEA 334
Cdd:cd17473 239 LAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPtLNSWAMSLVPPE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 489311504 335 PS-LAAASNHAAFNLANALGPWFGGMAITAGYGWTSTGYIGAATALVGLGIYLIAR 389
Cdd:cd17473 319 LRgRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
41-353 |
1.60e-10 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 62.21 E-value: 1.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 41 MPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFISGLPH 120
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 121 GAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVwqfvpdrhdep 200
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA----------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 201 rsdPRKELRAFTKPQVWMALSIGAIGFAGMFCVFsYLAPTMLEVTK-VSPQWIPFGLAAFGVGGIIGNIAGGKLFDRLQF 279
Cdd:cd17503 168 ---PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAM-FLLPLYLQNVLgYSAFESGLVLAPGGLASAILSPLVGRLLDKFGP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 280 RavgWIMVWSMAVLIFFTF-----------AASSLWGVLLGIGLVGTMIAMAAplqIRLMDIAHEAPSLAAASNHAAFNL 348
Cdd:cd17503 244 R---LLLLAGLLLLALGTLllafltpdtslWLIILPLFIRGLGMGLVFMPLNT---LALNSLPPEQIGDATALFNTIRQL 317
|
....*
gi 489311504 349 ANALG 353
Cdd:cd17503 318 GGSIG 322
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
36-390 |
2.51e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 61.45 E-value: 2.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 36 AIMG-LMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRF 114
Cdd:cd17365 16 AVMGfVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 115 ISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFaLVSAIALCTIAlvwqfvp 194
Cdd:cd17365 96 LTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVF-LLGGVPPLILL------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 195 drhdeprsdprkelraftkPQVWMALSIGAIGFAGMFCVF---SYLaPTMLEVTKVSPQWIPFGLAAFGVGGIIGNIAGG 271
Cdd:cd17365 168 -------------------PLLRGTLLLWVTFFMGLLLVYllnSWL-PKLMVEAGYSLSQALTITLLLNIGGVIGSLLLG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 272 KLFDRLQ-FRAVGWIMVWSMAVLIFFTFAASSLWGV-----LLGIGLVGTMIAMAA------PLQIRlmdiaheapSLAA 339
Cdd:cd17365 228 WLADRFGpKRVLALFFALGAVSLALLGVSPASLVLLyvlvfLAGACVNGAQVGLYAlaarfyPTEVR---------ATGV 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 489311504 340 ASNHAAFNLANALGPWFGGMAITAGYGWTSTGYIGAATALVGLGIYLIARR 390
Cdd:cd17365 299 GWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLRL 349
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
32-361 |
3.56e-10 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 61.09 E-value: 3.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 32 TGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVA 111
Cdd:PRK10213 34 IVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 112 FRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVWQ 191
Cdd:PRK10213 114 GRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGVLCIFWIIK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 192 FVPDRHDEPRSDPRKELRAFTKPQVWMALSIGAIGFAGMFCVFSYLAPTML-----EVTKVSPQWIPFGLAAFgvGGIIG 266
Cdd:PRK10213 194 SLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMnlagfGVDGLTLVLLSFGIASF--VGTSL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 267 NIAGGKLFDRLQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAPLQI--RLMDIAHEAPSLAAasnhA 344
Cdd:PRK10213 272 SSFILKRSVKLALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWGLTFALVPVGWSTWItrSLADQAEKAGSIQV----A 347
|
330
....*....|....*..
gi 489311504 345 AFNLANALGPWFGGMAI 361
Cdd:PRK10213 348 VIQLANTCGAAIGGYAL 364
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-325 |
4.68e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 60.65 E-value: 4.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 37 IMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFIS 116
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 117 GLPHGAYFGIAAVVAsSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVWQFVPDR 196
Cdd:cd17478 95 GIGSAAFHPEGARLA-SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 197 HDEPRSDPRKELRAFTKPQVWMALS-IGAIGFAGMFCVFSYLA--PTMLEVTKVSPQWIPFGLAAFGVGGIIGNIAGGKL 273
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWRALLlLLIIVFLRSWVLSSLTTflPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPL 253
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 489311504 274 FDRLQFRavgWIMVWSMAVLIFFT--FAASSLWGVLLGIGLVGTMIAMAAPLQI 325
Cdd:cd17478 254 SDRFGRR---RVIIASLLLAAPFLllFLLTPGIWSYILLVLAGFLLFASFPVTV 304
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
41-378 |
9.52e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.49 E-value: 9.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 41 MPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFISGLPH 120
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 121 GAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVwqfvpdrhdep 200
Cdd:cd17321 99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA----------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 201 rsdprkelraftkPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGLAAFGVGGIIGNIAGGKLFDRLQFR 280
Cdd:cd17321 168 -------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 281 AVGWIMVWSMAV---LIFFTFAASSLWGVLLGIGL--VGTMIAMAAPLQIRLMDIAHEAPSLAAASNHAAFNLANALGPW 355
Cdd:cd17321 235 LVLVAGLLLTAVgllLLALLGADSSVWLLLPGLVLlgLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVA 314
|
330 340
....*....|....*....|...
gi 489311504 356 FGGMAITAGYGWTSTGYIGAATA 378
Cdd:cd17321 315 LLGALLTAGLSANLGDSGVAALL 337
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
6-304 |
1.97e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 58.28 E-value: 1.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 6 TPGHVLPARSAAKMEAAMAVGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHM 85
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 86 LLLLMGLYALGNLATAFTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFL 165
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 166 GQHFGWRSAFALVSAIALCTIALVWQFvpdrhDEPRSDPRKELRAFTKPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVT 245
Cdd:COG0477 162 VAALGWRWIFLINAPLGLLALVLRLRL-----PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAG 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 489311504 246 KVSPQWIPFGLAAFGVGGIIGNIAGGKLFDRLQFRAVGWIMVWSMAVLIFFTFAASSLW 304
Cdd:COG0477 237 AALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
21-389 |
4.47e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 57.70 E-value: 4.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 21 AAMAVGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLAT 100
Cdd:cd06180 2 AGALALAVAMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 101 AFTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQH-FGWRSAFALVS 179
Cdd:cd06180 82 ALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGgLSWRAGWLALA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 180 AIALCTIALVWQFVPD-RHDEPRSDPRKELRAFTKPQVWMALSIGAIGFaGMFCVFSYLaPTMLEVTKVSPQWIPFGLAA 258
Cdd:cd06180 162 LLSAVLLLLSFLLLRRgPSAPTEASAAESAPGLNRPLWRLALAYGLFGF-GYIITATFL-PLIARETGAGSLLAGLLWSL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 259 FGVGGIIGNIAGGKLFDRLQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVG-TMIAMAAPLQIRLMDIAHEAPSL 337
Cdd:cd06180 240 FGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGgTFMAITALVMALARELAPPAAPR 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 489311504 338 AAASNHAAFNLANALGPWFGGMAITAGYGWTSTGYIGAATALVGLGIYLIAR 389
Cdd:cd06180 320 ALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALLVL 371
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
41-250 |
1.27e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 56.08 E-value: 1.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 41 MPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFISGLph 120
Cdd:PRK11102 14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL-- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 121 gayFGIAAVVASS-----MVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVWQFVPD 195
Cdd:PRK11102 92 ---AAAAASVVINalmrdMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPE 168
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489311504 196 RHDEPRSDP-------RKELRAFTKPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQ 250
Cdd:PRK11102 169 TLPKERRQPfhlrttiRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQ 230
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
35-386 |
5.74e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.14 E-value: 5.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 35 FAIMGLMPDIAH--NLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAF 112
Cdd:cd17316 16 FLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 113 RFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHF----GWRSAFALVSAIALCTIAL 188
Cdd:cd17316 96 RFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRILFLIGALPALLALLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 189 vwqfvpdrhdeprsdprkelraftKPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGLAAFGVGGIIGNI 268
Cdd:cd17316 176 ------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGAL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 269 AGGKLFDRLQFRAVGWIMVWSMAVL--IFFTFAASSLWGVLLGIGLVGTMIAMAAPLQIRLmdIAHEAPSLAAASNHAAF 346
Cdd:cd17316 232 IAGLLSDRIGRKKTLVIGLILSGILalPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAY--LAELFPTEVRATGVGLS 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 489311504 347 ----NLANALGPWFGGMAITAGYGWTSTGYIGAATALVGLGIYL 386
Cdd:cd17316 310 ynlgRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
42-320 |
6.15e-08 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 54.31 E-value: 6.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 42 PDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFISGLPHG 121
Cdd:TIGR00710 29 PEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGAS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 122 AYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVWQFVPDRH-DEP 200
Cdd:TIGR00710 109 AGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLpYEA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 201 RSDPRKELRAFTKP----QVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGLAAFGVGGIIGNIAGGKLFDR 276
Cdd:TIGR00710 189 RIQISTYFETFLLLlkskMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKK 268
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 489311504 277 LQFRAVGWIMVWSMAVLIFFTfAASSLWGVLLGIGLVGTMIAMA 320
Cdd:TIGR00710 269 WGAKSLLRMGLILFAVSAVLL-EITAILGLGSWAMIIGPMMFVG 311
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
37-194 |
6.89e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 50.65 E-value: 6.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 37 IMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFIS 116
Cdd:cd17323 18 YSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQ 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489311504 117 GLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVWQFVP 194
Cdd:cd17323 98 GFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLP 175
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
34-219 |
1.11e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 50.31 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 34 EFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFR 113
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 114 FISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHF-GWRSAFALVSAIALCTIALVWQF 192
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLF 174
|
170 180
....*....|....*....|....*..
gi 489311504 193 VPDRhdePRSDPRKELRAFTKPQVWMA 219
Cdd:cd17328 175 VREP---PRGAAEGGVMAKSTATSFLA 198
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-323 |
1.52e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.85 E-value: 1.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 19 MEAAMAVGAFAIGTGEFAIMG--------LMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLM 90
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGfatalwgpLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 91 GLYALGNLATAFTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRA---GAVARVMMGLTLAMLLGNpIATFLGQ 167
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASrlnLLHAFFSLGALLGPLLGG-LLILLGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 168 HFGWRSAFALVSAIALCTIALVWQF----VPDRHDEPRSDPRKELRAFTKPQVWMALSIGAIGFAGMFCVFSYLAPTMLE 243
Cdd:COG0738 160 SLSWHLPYLILAVLLLLLALLFLRSklpeIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 244 VTKVSPQWIPFGLAAFGVGGIIGNIAGGKLFDRLQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAPL 323
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPT 319
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
138-323 |
4.56e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.36 E-value: 4.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 138 DKRAGAVARVMMGLTLAMLLGNPIATFLGQHF------GWRSAFALVSAIALCTIALVWQFVPDRH--DEPRSDPRKELR 209
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPvpEEEKVSLKESLK 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 210 AFTKPQVWMALSIGAI-GFAGMFCVFSYLAPTMLEVTKVSPQWIPFGLAAFGVGGIIGNIAGGKLFDRLQFRAV--GWIM 286
Cdd:COG2211 223 ALLKNRPFLLLLLAYLlFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAfiIGLL 302
|
170 180 190
....*....|....*....|....*....|....*..
gi 489311504 287 VWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAPL 323
Cdd:COG2211 303 LAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVL 339
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
23-190 |
1.97e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.41 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 23 MAVGAFAIGTGEFAIMGLMPDIAHNL-NLSEPQVGHAISAYALGVMVGAPLLA-ILGAKLLRKHMLLLLMGLYALGNLAT 100
Cdd:cd17474 203 FLVSAFLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 101 AFTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSA 180
Cdd:cd17474 283 GFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAA 362
|
170
....*....|
gi 489311504 181 IALCTIALVW 190
Cdd:cd17474 363 IALAAAVLLA 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
22-196 |
2.75e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.63 E-value: 2.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 22 AMAVGAFAIGTGEFAIMGLMPDIAHN-LNLSEPQVGHAISAYALGVMVGAPLLAILG--AKLLRKHMLLLLMGLYALGNL 98
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSdrLGRRRKLVLAIGLLLAALALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 99 ATAFTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALV 178
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLL 343
|
170
....*....|....*...
gi 489311504 179 SAIALCTIALVWQFVPDR 196
Cdd:COG2271 344 AALALLAALLALLLLRET 361
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
40-370 |
3.86e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 45.44 E-value: 3.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 40 LMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFISGLP 119
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 120 HGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATF-LGQHFGWRSAFALVSAIALcTIALVWQFV----- 193
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAI-IVSLICFLLlrdsp 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 194 ---------PDRHDEPRSDPRKELRAFTKPQVWMA----------LSIGAIGFAGM-FCVFSYLAPTMLEVTKVSPQWIP 253
Cdd:TIGR00881 176 qscglppaeEMPNEEPDGDAEKKEEELTKKQIFLQyvllnkvlwyISLGYVFVYVVrTGILDWSPLYLTQEKGFSKEKAS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 254 FGLAAFGVGGIIGNIAGGKLFDRLqFRAVGWIMVWSMAVLIFFTFAasSLWGVLLGIGLVGTMIAMAA------PLQIRL 327
Cdd:TIGR00881 256 WAFTLYELGGLVGTLLAGWLSDKL-FNGRRGPLAVFFMALIIVSLL--VYWLNPAANPLMDLICLFALgflvygPQMLIG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 489311504 328 MDIAHEAPSLAAASNHAAFNLANALGPWFGGMA---ITAGYGWTST 370
Cdd:TIGR00881 333 VIASELAPKKAAGTAAGFVGFFAYLGGILAGLPlgyLADGFGWAGA 378
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
23-194 |
5.04e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.88 E-value: 5.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 23 MAVGAFAIGTGEFAIMGLMPDI---AHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLA 99
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 100 TAFTPTFGSLVAFRFISGLpHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVS 179
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170
....*....|....*
gi 489311504 180 AIALCTIALVWQFVP 194
Cdd:cd17330 160 ALALLNLVLVLFFLP 174
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
23-190 |
5.97e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.91 E-value: 5.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 23 MAVGAFAIGTGEFAIMGLMPDIA-HNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATA 101
Cdd:cd06173 213 LLLALALFALLGGALTVLLPLLAkEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLG 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 102 FTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAI 181
Cdd:cd06173 293 LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGAL 372
|
....*....
gi 489311504 182 ALCTIALVW 190
Cdd:cd06173 373 LLLAALLLL 381
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
98-194 |
1.03e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.15 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 98 LATAFTPTF-----GSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWR 172
Cdd:cd17318 98 LLTLLTPLAarggyGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWP 177
|
90 100
....*....|....*....|..
gi 489311504 173 SAFALVSAIALCTIALVWQFVP 194
Cdd:cd17318 178 SIFYIFGGLGLLWCLLWFFLVL 199
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
168-386 |
1.32e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 168 HFGWRSAFALVSAIALCTIALVWQFVPDRHDEPRSDPRKELRAFTK--PQVWMALSIGAIGFAGMFCvFSYLAPTMLEVT 245
Cdd:cd17370 152 GGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKlpKAFWLYLLAVALFALGNFS-FAFLILRAQELG 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 246 kVSPQWIPFGLAAFGVGGIIGNIAGGKLFDRLQFRAVgWIMVWSMAVLIFFTFA-ASSLWGVLLGIGLVGtmIAMAAPLQ 324
Cdd:cd17370 231 -LSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKL-LILGYLSLALAYLGFAlGSSLWLLLLGFILWG--LYMGAQES 306
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489311504 325 IRLMDIAHEAPSLAAASNHAAFNLANALGpWFGGMAItAGYGWTSTGY-----IGAATALVGLGIYL 386
Cdd:cd17370 307 IERAAVADLVPAELRGTAYGLFNTVVGIG-WLLASLI-AGYLWDLISPsaaflFSAVLALIALLLLL 371
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
114-207 |
1.41e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 43.75 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 114 FISGLP----HGayFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALV 189
Cdd:cd17331 92 FLSRLPsvfmHA--MQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLV 169
|
90
....*....|....*...
gi 489311504 190 WQFVPDRHDEPRSDPRKE 207
Cdd:cd17331 170 ILLIPSNTKSKREKEAKE 187
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
42-195 |
3.71e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 42.26 E-value: 3.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 42 PDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFISGLPHG 121
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489311504 122 AYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVWQFVPD 195
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPE 192
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
98-195 |
3.82e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 42.29 E-value: 3.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 98 LATAFTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLT----LAMLLGNPIATFLGQHFGWRS 173
Cdd:cd17371 79 LLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwlLATLLAALLFPLLPPEIAWRV 158
|
90 100
....*....|....*....|..
gi 489311504 174 AFaLVSAIALCTIALVWQFVPD 195
Cdd:cd17371 159 LF-LLGALPALLVLFIRRFVKE 179
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
133-387 |
7.77e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 7.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 133 SMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVWQFVPDRHDEPRSDPRKELRAFT 212
Cdd:cd06173 119 ELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLR 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 213 K--------PQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGLAAFGVGGIIGNIAGGKLFDRLQFRAVGW 284
Cdd:cd06173 199 EglrylrrsPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 285 IMVWSMAVLIFFTFAASSLWGVLLGIGLVGTMIAMAAPLQIRLMDIAHEAPSLA--AASNHAAFNLANALGPWFGGMAIT 362
Cdd:cd06173 279 IGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGrvFSVYNALNSGAMPLGALLAGLLAD 358
|
250 260
....*....|....*....|....*
gi 489311504 363 AGYGWTSTGYIGAATALVGLGIYLI 387
Cdd:cd06173 359 ALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
102-231 |
7.81e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.44 E-value: 7.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 102 FTPTFGSLVAFRFISGLPhGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAI 181
Cdd:cd17490 81 LFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALA 159
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 489311504 182 ALctIALVWQFV---PDRHDEPRSDPRKELRA-FTKPQVW----MALSIGAIGFAGMF 231
Cdd:cd17490 160 GV--LGFILSLFikeERREKKPVLTELKELLSvLKDKKLLffslLAILQQMITFSTTF 215
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
25-189 |
1.48e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 25 VGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTP 104
Cdd:cd17477 195 LGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVP 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 105 TFG-SLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIAL 183
Cdd:cd17477 275 GLPlALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVAL 354
|
....*.
gi 489311504 184 CTIALV 189
Cdd:cd17477 355 LFLLFL 360
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
54-194 |
1.52e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.26 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 54 QVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTPTFGSLVAFRFISGLPHGAYFGIAAVVASS 133
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489311504 134 MVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQhfgWRSaFALVSAIALCTIALVWQFVP 194
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRW-LQLAISLPGLLFLLLLWWLP 162
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
25-388 |
2.12e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 25 VGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYALGNLATAFTP 104
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 105 TFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQhfgwRSAFALVSAIALC 184
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT----AGALPFLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 185 TIALVWQFVPdRHDEPRSDPRKELRAFTKPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWIPFGLAAFGVGGI 264
Cdd:cd17477 159 LLALVPLLLT-RRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 265 IGNIAGGKLFDRLQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVGTmiAMAAPLQ-IRLMDIAHEAPSLAAASNH 343
Cdd:cd17477 238 LLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWG--GAAGPLYtLALALAGDRLPGDELVAAN 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 489311504 344 AAFNLANALGPWFGGMAITAGYGWTSTGYIGAATALVGLGIYLIA 388
Cdd:cd17477 316 AALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
23-389 |
2.34e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.90 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 23 MAVGAFAIGTGEFAIMGLMPD-IAHNLNLSEPQVGHAISAYALgVMVGAPLLA-----ILGAKLLRKHMLLLLMGLYALG 96
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAV-AGIVASLIGgrladRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 97 NLATAFTPTFGSLVAFRFISGLphgaYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQhFGWRSAFA 176
Cdd:cd17329 83 GFAHSPWLFAIALVLTGFGGGL----FEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 177 LVSAIALCTIALVWQFVPD----RHDEPRSDPRKELRAFTKPQVWMALSIGAIGFAGMFCVFSYLAPTMLEVTKVSPQWI 252
Cdd:cd17329 158 AAAVLFLLAALVLLFLLPEtrpkRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 253 P-FGLAAFGVGGIIGNIAGGKLFDRLQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGL--VGTMIA--MAAPLQIRL 327
Cdd:cd17329 238 LgLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVltLGEMLVfpAVQTLVAAL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489311504 328 MDIAHEAPSLAAASNHAAfnLANALGPWFGGMAITAGYGWtSTGYIGAATALVGLGIYLIAR 389
Cdd:cd17329 318 APPDKRGSYMGFYALAWG--LGRAIGPLVGGLLLDLLGPG-LPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
98-193 |
2.91e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 39.46 E-value: 2.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 98 LATAFTPTF-----GSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWR 172
Cdd:cd17380 76 LATLLTPLLaysslPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWP 155
|
90 100
....*....|....*....|.
gi 489311504 173 SAFALVSAIALcTIALVWQFV 193
Cdd:cd17380 156 SVFYFFGLLGL-LWALVWLIY 175
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
22-165 |
3.44e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.07 E-value: 3.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 22 AMAVGAFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGAPLLAILGAKLLRKHMLLLLMGLYAL--GNLA 99
Cdd:cd17352 187 LLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILglSLLA 266
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489311504 100 TAFTPTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFL 165
Cdd:cd17352 267 FPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLL 332
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
57-190 |
4.75e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.68 E-value: 4.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 57 HAISAYALGVM---VGAPLLAILGAKLLRKHmllllmglyalgNLATAFTPTFGSLVAFRFISGLPHGAYFGIAAVVASS 133
Cdd:cd17370 247 YALAAYPAGRLsdrIGRKKLLILGYLSLALA------------YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVAD 314
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 489311504 134 MVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFGWRSAFALVSAIALCTIALVW 190
Cdd:cd17370 315 LVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
27-386 |
6.88e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 38.12 E-value: 6.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 27 AFAIGTGEFAIMGLMPDIAHNLNLSEPQVGHAISAYALGVMVGApLLAILGAKLLRKHMLLLLMGLYALGNLAT---AFT 103
Cdd:pfam06779 2 TVGMGIGRFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGA-LLASFAWRHGASRLRPALLAGLLATVLLLlamAAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 104 PTFGSLVAFRFISGLPHGAYFGIAAVVASSMVPNDKRAGAVARVMMGLTLAMLLGNPIATFLGQHFG----WRSAFALVS 179
Cdd:pfam06779 81 SSFWAVLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLGLggssLWYGAGVLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 180 AIALCTIALVWQFVPDRHDEPRSDPRKELRAfTKPQVWMALSIGAIGFaGMFCVFSYLAPTMLEVTKVSPQ----WIPFG 255
Cdd:pfam06779 161 AVLTLAVFPLLPRRAPRHASAPAPAAKPLQR-SLPLWILTLAYGLAGF-GYIITATFLPAMARDGFGGPAAaalfWSLFG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311504 256 LAAFGVGGIIGNIAggklfDRLQFRAVGWIMVWSMAVLIFFTFAASSLWGVLLGIGLVG--TMIAMAAPLQIRLMDIAHE 333
Cdd:pfam06779 239 LAAALGVLVWLRAA-----KRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGgtFMAITSLVMQLARELAPPA 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489311504 334 APSLAAASNhAAFNLANALGPWFGGMAITAGYGWTSTGYIGAATALVGLGIYL 386
Cdd:pfam06779 314 PRRLLGLMT-ASFGIGQILGPLLASLLTAATGGLTPALLLAAAALVLAALIVL 365
|
|
| |
