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Conserved domains on  [gi|489311579|ref|WP_003218985|]
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MULTISPECIES: universal stress protein [Pseudomonas]

Protein Classification

universal stress protein( domain architecture ID 10001747)

universal stress protein (USP) enhances the rate of cell survival during prolonged exposure to stress agents

CATH:  3.40.50.620
Gene Ontology:  GO:0042802
PubMed:  23745136|9405142|12732303
SCOP:  8083864

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
2-139 1.34e-31

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 109.63  E-value: 1.34e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579   2 PYEHILVAVDLTEECDPVIKRAVGLAG-DSVKLSLVHIVEPMAMAFGGDVPMDLSQLQQqqfdqAKERLDRLINKYPALK 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKaLGAELHLLHVVDPPPSAAAGPEELEEELREE-----AEEALEEAAERLEEAG 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489311579  81 KD-QSHLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGLA-LLLGSTANDVLHGAPCDVLAV 139
Cdd:COG0589   76 VEvETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRrLLLGSVAERVLRHAPCPVLVV 136
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
2-139 1.34e-31

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 109.63  E-value: 1.34e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579   2 PYEHILVAVDLTEECDPVIKRAVGLAG-DSVKLSLVHIVEPMAMAFGGDVPMDLSQLQQqqfdqAKERLDRLINKYPALK 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKaLGAELHLLHVVDPPPSAAAGPEELEEELREE-----AEEALEEAAERLEEAG 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489311579  81 KD-QSHLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGLA-LLLGSTANDVLHGAPCDVLAV 139
Cdd:COG0589   76 VEvETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRrLLLGSVAERVLRHAPCPVLVV 136
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 3-141 5.64e-31

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 108.16  E-value: 5.64e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579   3 YEHILVAVDLTEECDPVIKRAVGLAGD-SVKLSLVHIVEPMAMAFGGDVPMDLSQLQQQQFDQAKERLDRLiNKYPALKK 81
Cdd:cd23657    1 YKHILVAVDLSPESQSLVDKAVEIAREnDAKLSLIHVDEDISEYYTGLIDVDIAALQDLESTMLEEALKNL-SELAGYPV 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579  82 DQSHLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGLAlLLGSTANDVLHGAPCDVLAVKL 141
Cdd:cd23657   80 DHTFIGYGDLKEEILEVAKKHNVDLIVCGHHGDFGLS-LLGSSARAVLNSAPCDVLIVPL 138
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 6-140 1.06e-28

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 102.10  E-value: 1.06e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579    6 ILVAVDLTEECDPVIKRAVGLAGDS-VKLSLVHIVEPMAMAFGGDVPMDLSQLQQQQFDQAKERLDRLINKYPALKKDQS 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARgAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 489311579   85 HLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGLA-LLLGSTANDVLHGAPCDVLAVK 140
Cdd:pfam00582  81 VVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSrLLLGSVAEYVLRHAPCPVLVVR 137
PRK15005 PRK15005
universal stress protein UspF;
65-140 1.61e-08

universal stress protein UspF;


Pssm-ID: 184967 [Multi-domain]  Cd Length: 144  Bit Score: 50.19  E-value: 1.61e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489311579  65 AKERLDRLINKY--PALKKdQSHLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGLALLLGSTANDVLHGAPCDVLAVK 140
Cdd:PRK15005  68 AKSQLEEIIKKFklPTDRV-HVHVEEGSPKDRILELAKKIPADMIIIASHRPDITTYLLGSNAAAVVRHAECSVLVVR 144
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
2-139 1.34e-31

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 109.63  E-value: 1.34e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579   2 PYEHILVAVDLTEECDPVIKRAVGLAG-DSVKLSLVHIVEPMAMAFGGDVPMDLSQLQQqqfdqAKERLDRLINKYPALK 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKaLGAELHLLHVVDPPPSAAAGPEELEEELREE-----AEEALEEAAERLEEAG 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489311579  81 KD-QSHLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGLA-LLLGSTANDVLHGAPCDVLAV 139
Cdd:COG0589   76 VEvETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRrLLLGSVAERVLRHAPCPVLVV 136
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 3-141 5.64e-31

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 108.16  E-value: 5.64e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579   3 YEHILVAVDLTEECDPVIKRAVGLAGD-SVKLSLVHIVEPMAMAFGGDVPMDLSQLQQQQFDQAKERLDRLiNKYPALKK 81
Cdd:cd23657    1 YKHILVAVDLSPESQSLVDKAVEIAREnDAKLSLIHVDEDISEYYTGLIDVDIAALQDLESTMLEEALKNL-SELAGYPV 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579  82 DQSHLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGLAlLLGSTANDVLHGAPCDVLAVKL 141
Cdd:cd23657   80 DHTFIGYGDLKEEILEVAKKHNVDLIVCGHHGDFGLS-LLGSSARAVLNSAPCDVLIVPL 138
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 6-140 1.06e-28

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 102.10  E-value: 1.06e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579    6 ILVAVDLTEECDPVIKRAVGLAGDS-VKLSLVHIVEPMAMAFGGDVPMDLSQLQQQQFDQAKERLDRLINKYPALKKDQS 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARgAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 489311579   85 HLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGLA-LLLGSTANDVLHGAPCDVLAVK 140
Cdd:pfam00582  81 VVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSrLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 5-139 1.30e-24

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 91.64  E-value: 1.30e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579   5 HILVAVDLTEECDPVIKRAVGLAG-DSVKLSLVHIVEPMAMAFggdVPMDLSQLQQQQFDQAKERLDRLINKYPALKKD- 82
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKrPGAELTLLHVVDPPPSSS---LSGGLEELADELKEEAEELLEEAKKLAEEAGVEv 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489311579  83 QSHLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGL-ALLLGSTANDVLHGAPCDVLAV 139
Cdd:cd00293   78 ETIVVEGDPAEAILEEAKELGADLIVMGSRGRSGLkRLLLGSVSEYVLRHAPCPVLVV 135
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 5-140 1.88e-18

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 76.12  E-value: 1.88e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579   5 HILVAVDLTEECDPVIKRAVG-LAGDSVKLSLVHIVEPMAMAFGGDVPMDLSQLQQQQFdqAKERLDRLINKYPALKKDQ 83
Cdd:cd23659    2 KVLIAVDGSEESEYALEWALEnLHRPGDEVVLLHVIEPPSLPAASLGSGSEEWEALEEE--AREKAEKLLEKYEKKLKEE 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489311579  84 SHLTY------GQPRQEIHHLAKEQGCDLIVVGSHGRHGLA-LLLGSTANDVLHGAPCDVLAVK 140
Cdd:cd23659   80 KGIKVkvevvaGDPGEVICKAAEELKADLIVMGSRGLGALKrTLLGSVSDYVVHHSPCPVLVVR 143
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 5-140 1.54e-09

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 53.04  E-value: 1.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579   5 HILVAVDL-TEECDP------VIKRAVGLAG-DSVKLSLVHiVEPMAMAFGGDVPMDLSQLQQQQFDQAKER--LDRLIN 74
Cdd:cd23660    3 RILVAVDPsNEEEYHedlnlrLIELAYSLAAqLKAELHLVS-AWPVTPENIAIELPEFDPTEYVDAIRGRHLeaMKALRQ 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489311579  75 KYpALKKDQSHLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGL-ALLLGSTANDVLHGAPCDVLAVK 140
Cdd:cd23660   82 KF-GIDEEQTHVLEGLPEEVIPDFAEELDADIVVLGTVARTGLsGALIGNTAEHVLDHLNCDLLALK 147
USP_Rv2623_repeat2 cd23661
universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis ...
 66-140 3.93e-09

universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition, Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467507 [Multi-domain]  Cd Length: 133  Bit Score: 51.74  E-value: 3.93e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489311579  66 KERLDRLINKYPALKKDQShLTYGQPRQEIHHLAKEqgCDLIVVGSHGRHGLA-LLLGSTANDVLHGAPCDVLAVK 140
Cdd:cd23661   61 AERLAGWQERYPDVHVHKV-VVRDRPARVLLEASER--AQLVVVGSHGRGGFAgMLLGSVSRAVLHSAPCPVIVVR 133
PRK15005 PRK15005
universal stress protein UspF;
65-140 1.61e-08

universal stress protein UspF;


Pssm-ID: 184967 [Multi-domain]  Cd Length: 144  Bit Score: 50.19  E-value: 1.61e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489311579  65 AKERLDRLINKY--PALKKdQSHLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGLALLLGSTANDVLHGAPCDVLAVK 140
Cdd:PRK15005  68 AKSQLEEIIKKFklPTDRV-HVHVEEGSPKDRILELAKKIPADMIIIASHRPDITTYLLGSNAAAVVRHAECSVLVVR 144
PRK11175 PRK11175
universal stress protein UspE; Provisional
 66-140 4.61e-07

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 47.57  E-value: 4.61e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489311579  66 KERLDRLINKYpALKKDQSHLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGL-ALLLGSTANDVLHGAPCDVLAVK 140
Cdd:PRK11175 225 LLAMKALRQKF-GIDEEQTHVEEGLPEEVIPDLAEHLDAELVILGTVGRTGLsAAFLGNTAEHVIDHLNCDLLAIK 299
PRK10116 PRK10116
universal stress protein UspC; Provisional
 1-144 8.71e-06

universal stress protein UspC; Provisional


Pssm-ID: 182248  Cd Length: 142  Bit Score: 42.77  E-value: 8.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579   1 MPYEHILVAVDLTEECDPVIKRAVGLAGD-SVKLSLVHIV-EP-MAMAFGGdvPMdLSQLQQQQFDQAKERLDRLINK-- 75
Cdd:PRK10116   1 MSYSNILVAVAVTPESQQLLAKAVSIARPvNGKISLITLAsDPeMYNQFAA--PM-LEDLRSVMQEETQSFLDKLIQDad 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489311579  76 YPAlkkDQSHLTYGQPRQEIHHLAKEQGCDLIVVGSHGrHGLALLLGSTANDVLHGAPCDVLAVKLVKS 144
Cdd:PRK10116  78 YPI---EKTFIAYGELSEHILEVCRKHHFDLVICGNHN-HSFFSRASCSAKRVIASSEVDVLLVPLTGD 142
PRK15456 PRK15456
universal stress protein UspG; Provisional
 3-140 8.10e-05

universal stress protein UspG; Provisional


Pssm-ID: 185353  Cd Length: 142  Bit Score: 40.31  E-value: 8.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579   3 YEHILVAVDL--TEECDPVIKRAVGLAGDSVKLSLVHIVEPMA----MAFGGDVpmdlSQLQQQQFDQAKERLDRLINKY 76
Cdd:PRK15456   2 YKTIIMPVDVfeMELSDKAVRHAEFLAQDDGVIHLLHVLPGSAslslHRFAADV----RRFEEHLQHEAEERLQTMVSHF 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489311579  77 ---PAlkKDQSHLTYGQPRQEIHHLAKEQGCDLIVVGSHGRHGLALLLGSTANDVLHGAPCDVLAVK 140
Cdd:PRK15456  78 tidPS--RIKQHVRFGSVRDEVNELAEELGADVVVIGSRNPSISTHLLGSNASSVIRHANLPVLVVR 142
PRK15118 PRK15118
universal stress protein UspA;
1-38 3.63e-04

universal stress protein UspA;


Pssm-ID: 185073  Cd Length: 144  Bit Score: 38.33  E-value: 3.63e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 489311579   1 MPYEHILVAVDLTEECDPVIKRAVGLAG-DSVKLSLVHI 38
Cdd:PRK15118   1 MAYKHILIAVDLSPESKVLVEKAVSMARpYNAKVSLIHV 39
USP_Rv2623_repeat1 cd23944
universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis ...
 6-136 5.53e-03

universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467509  Cd Length: 140  Bit Score: 35.07  E-value: 5.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489311579   6 ILVAVDLTEECDpvikRAVGLAGD-----SVKLSLVHIVEPMAMAFGGDVPMDLSQL-----QQQQFDQAKERLDRLINK 75
Cdd:cd23944    2 IIVGVDGSPASD----AAVRWAAReaqlrQIPLTLVHVVPPVVVSWPEGPRPAEVLDwqqdeARQVIEQARKVAEEASGE 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489311579  76 YPALKKdQSHLTYGQPRQEIhhLAKEQGCDLIVVGSHGRHGLA-LLLGSTANDVLHGAPCDV 136
Cdd:cd23944   78 GPPVKV-ETEIVPGSPVPTL--VEASRDATMVVVGSRGIGALAgLLLGSVSTSLVRHAHCPV 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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