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Conserved domains on  [gi|489327669|ref|WP_003234960|]
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MULTISPECIES: DUF523 domain-containing protein [Bacillus]

Protein Classification

DUF523 domain-containing protein( domain architecture ID 10517206)

DUF523 domain-containing protein may be involved in the conversion of 2-thiouracil to uracil; similar to Bacillus subtilis YbbK

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2-thiour_desulf pfam04463
2-thiouracil desulfurase; This family of proteins, predominantly found in Bacteria, are ...
2-146 1.86e-66

2-thiouracil desulfurase; This family of proteins, predominantly found in Bacteria, are involved in the desulfuration of 2-thiouracil into uracil in the 2-thiouridine degradation pathway. It has been demonstrated that these proteins contain a Fe-S cluster required for their activity.


:

Pssm-ID: 461320  Cd Length: 137  Bit Score: 198.06  E-value: 1.86e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489327669    2 ILVSSCLGGIECRYNGSHAAS--EKIRKLVDEKKAVMACPELLGGFSTPREPAEIIGgtgedvlngtAKIVTASGEDVTE 79
Cdd:pfam04463   1 ILVSACLLGENCRYDGGHKRDvnEVLAKLVREGEFIPVCPEVLGGLPTPRPPAEIVG----------ARVQTKTGEDVTE 70
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489327669   80 LYMEGAAKTLAYAKEINASAVILKENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENE 146
Cdd:pfam04463  71 AFLRGAEEALELAKEEGIDGAILKSKSPSCGSGRIYDGTFSGTLIPGVGVFAALLKEHGPLVPVEEE 137
 
Name Accession Description Interval E-value
2-thiour_desulf pfam04463
2-thiouracil desulfurase; This family of proteins, predominantly found in Bacteria, are ...
2-146 1.86e-66

2-thiouracil desulfurase; This family of proteins, predominantly found in Bacteria, are involved in the desulfuration of 2-thiouracil into uracil in the 2-thiouridine degradation pathway. It has been demonstrated that these proteins contain a Fe-S cluster required for their activity.


Pssm-ID: 461320  Cd Length: 137  Bit Score: 198.06  E-value: 1.86e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489327669    2 ILVSSCLGGIECRYNGSHAAS--EKIRKLVDEKKAVMACPELLGGFSTPREPAEIIGgtgedvlngtAKIVTASGEDVTE 79
Cdd:pfam04463   1 ILVSACLLGENCRYDGGHKRDvnEVLAKLVREGEFIPVCPEVLGGLPTPRPPAEIVG----------ARVQTKTGEDVTE 70
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489327669   80 LYMEGAAKTLAYAKEINASAVILKENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENE 146
Cdd:pfam04463  71 AFLRGAEEALELAKEEGIDGAILKSKSPSCGSGRIYDGTFSGTLIPGVGVFAALLKEHGPLVPVEEE 137
YbbK COG1683
Uncharacterized conserved protein YbbK, DUF523 family [Function unknown];
2-150 3.00e-64

Uncharacterized conserved protein YbbK, DUF523 family [Function unknown];


Pssm-ID: 441289  Cd Length: 149  Bit Score: 193.04  E-value: 3.00e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489327669   2 ILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGGFSTPREPAEIIGGTGEDVLngtakIVTASGEDVTELY 81
Cdd:COG1683    4 ILVSACLLGEPVRYDGGHKRDPFVEELAKYGEFVPVCPEVAGGLPTPRPPAEIVGGDGEVRV-----VQTKTGEDVTEAF 78
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489327669  82 MEGAAKTLAYAKEINASAVILKENSPSCGSGF-IYNGTFSGKKITGSGVTAALLKQAGYRVISENE-LNDI 150
Cdd:COG1683   79 LAGAEEALKLAREHGIDGAILKSKSPSCGSGRkIYDGTFSGTLKKGVGVFAALLKENGPLVVEEEGrLNDP 149
 
Name Accession Description Interval E-value
2-thiour_desulf pfam04463
2-thiouracil desulfurase; This family of proteins, predominantly found in Bacteria, are ...
2-146 1.86e-66

2-thiouracil desulfurase; This family of proteins, predominantly found in Bacteria, are involved in the desulfuration of 2-thiouracil into uracil in the 2-thiouridine degradation pathway. It has been demonstrated that these proteins contain a Fe-S cluster required for their activity.


Pssm-ID: 461320  Cd Length: 137  Bit Score: 198.06  E-value: 1.86e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489327669    2 ILVSSCLGGIECRYNGSHAAS--EKIRKLVDEKKAVMACPELLGGFSTPREPAEIIGgtgedvlngtAKIVTASGEDVTE 79
Cdd:pfam04463   1 ILVSACLLGENCRYDGGHKRDvnEVLAKLVREGEFIPVCPEVLGGLPTPRPPAEIVG----------ARVQTKTGEDVTE 70
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489327669   80 LYMEGAAKTLAYAKEINASAVILKENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENE 146
Cdd:pfam04463  71 AFLRGAEEALELAKEEGIDGAILKSKSPSCGSGRIYDGTFSGTLIPGVGVFAALLKEHGPLVPVEEE 137
YbbK COG1683
Uncharacterized conserved protein YbbK, DUF523 family [Function unknown];
2-150 3.00e-64

Uncharacterized conserved protein YbbK, DUF523 family [Function unknown];


Pssm-ID: 441289  Cd Length: 149  Bit Score: 193.04  E-value: 3.00e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489327669   2 ILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGGFSTPREPAEIIGGTGEDVLngtakIVTASGEDVTELY 81
Cdd:COG1683    4 ILVSACLLGEPVRYDGGHKRDPFVEELAKYGEFVPVCPEVAGGLPTPRPPAEIVGGDGEVRV-----VQTKTGEDVTEAF 78
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489327669  82 MEGAAKTLAYAKEINASAVILKENSPSCGSGF-IYNGTFSGKKITGSGVTAALLKQAGYRVISENE-LNDI 150
Cdd:COG1683   79 LAGAEEALKLAREHGIDGAILKSKSPSCGSGRkIYDGTFSGTLKKGVGVFAALLKENGPLVVEEEGrLNDP 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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