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Conserved domains on  [gi|489332405|ref|WP_003239655|]
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MULTISPECIES: PepSY domain-containing protein [Pseudomonadaceae]

Protein Classification

PepSY domain-containing protein( domain architecture ID 11461384)

PepSY (peptidase propeptide and YPEB) domain-containing protein may act as a regulator of peptidase activity and may also function in protecting the cell from lysis; similar to Bacillus subtilis uncharacterized protein YkoJ and YkoI

CATH:  3.10.450.40
PubMed:  15124630

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YkoI COG3212
PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational ...
 37-102 9.61e-19

PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 442445  Cd Length: 66  Bit Score: 72.93  E-value: 9.61e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489332405  37 GTIKSFEQLDEAILAQHPGaRIEETELEDEYGRYIYQVDLRDAQGQQWDLELDASTGEILKNHQDD 102
Cdd:COG3212    2 GAIISLEQALEIALARVPG-RVLEVELERDDGRLVYEVEILTPDGRVYEVEVDAKTGEVLKVEEDD 66
 
Name Accession Description Interval E-value
YkoI COG3212
PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational ...
 37-102 9.61e-19

PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442445  Cd Length: 66  Bit Score: 72.93  E-value: 9.61e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489332405  37 GTIKSFEQLDEAILAQHPGaRIEETELEDEYGRYIYQVDLRDAQGQQWDLELDASTGEILKNHQDD 102
Cdd:COG3212    2 GAIISLEQALEIALARVPG-RVLEVELERDDGRLVYEVEILTPDGRVYEVEVDAKTGEVLKVEEDD 66
PepSY pfam03413
Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory ...
 41-97 1.12e-09

Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase _ Bacillus subtilis YPEB.


Pssm-ID: 427284 [Multi-domain]  Cd Length: 59  Bit Score: 49.98  E-value: 1.12e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 489332405   41 SFEQLDEAILAQHPGARIEeTELEDEYGRYIYQVDLrDAQGQQWDLELDASTGEILK 97
Cdd:pfam03413   3 SLEQALAIALKAVPGAVIE-AELEPEDGKLVYEVEV-DPDGREYEVYIDAYTGEVLK 57
 
Name Accession Description Interval E-value
YkoI COG3212
PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational ...
 37-102 9.61e-19

PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442445  Cd Length: 66  Bit Score: 72.93  E-value: 9.61e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489332405  37 GTIKSFEQLDEAILAQHPGaRIEETELEDEYGRYIYQVDLRDAQGQQWDLELDASTGEILKNHQDD 102
Cdd:COG3212    2 GAIISLEQALEIALARVPG-RVLEVELERDDGRLVYEVEILTPDGRVYEVEVDAKTGEVLKVEEDD 66
PepSY pfam03413
Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory ...
 41-97 1.12e-09

Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase _ Bacillus subtilis YPEB.


Pssm-ID: 427284 [Multi-domain]  Cd Length: 59  Bit Score: 49.98  E-value: 1.12e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 489332405   41 SFEQLDEAILAQHPGARIEeTELEDEYGRYIYQVDLrDAQGQQWDLELDASTGEILK 97
Cdd:pfam03413   3 SLEQALAIALKAVPGAVIE-AELEPEDGKLVYEVEV-DPDGREYEVYIDAYTGEVLK 57
PiuB COG3182
PepSY-associated TM region [Function unknown];
29-97 4.26e-05

PepSY-associated TM region [Function unknown];


Pssm-ID: 442415 [Multi-domain]  Cd Length: 379  Bit Score: 40.33  E-value: 4.26e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489332405  29 EAKRLQDAGTIKSFEQLDEAILAQHPGARIEETELEDEYGRYIyQVDLRDAQGQQWDLELDASTGEILK 97
Cdd:COG3182   45 ELLAVAPGGPPLSLDELLAAARAAYPGARVTSITLPAEPDRAA-RVRVRDPEGEGRTVYVDPYTGEVLG 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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