|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-469 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 780.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 1 MTVRRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFT 80
Cdd:PRK05826 1 RMLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 81 DKRIELKVGDKFTFSTAhPLTSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGPLSDHKGI 160
Cdd:PRK05826 81 EGKITLKTGDKFTLDTD-QKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 161 NRRGGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESGG-TAWLVAKIERAEAVANdevLDELIR 239
Cdd:PRK05826 160 NIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVDN---IDEIIE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 240 ASDAVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAES 319
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 320 AAGSYPIEAVQAMARICIGAEKHPTGKTSSHRIGHSFTRCDESIALAAMYTANHFPGVKAIIALTESGYTPLIMSRIRSS 399
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPG 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 400 VPIYAFSPHRGTQARAAMFRGVYTVPFDPAAlPPGQVSQAAVDELLKRGLVEQGDWVILTKGDSYHTIGG 469
Cdd:PRK05826 397 APIFAVTRDEKTQRRLALYRGVYPVLFDSAA-DTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAGG 465
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
4-478 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 734.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTDKR 83
Cdd:COG0469 3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 84 IELKVGDKFTFSTAHplTSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGPLSDHKGINRR 163
Cdd:COG0469 83 VELKKGDTFTLTTDD--VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 164 GGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESGGTAWLVAKIERAEAVANdevLDELIRASDA 243
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVEN---LDEIIEASDG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 244 VMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAESAAGS 323
Cdd:COG0469 238 IMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGK 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 324 YPIEAVQAMARICIGAEKHPTGKTSSHRI-GHSFTRCDESIALAAMYTANHFpGVKAIIALTESGYTPLIMSRIRSSVPI 402
Cdd:COG0469 318 YPVEAVETMARIAEEAEKSLDYRRILDRLrDEPERTITDAIARAAVELAEDL-GAKAIVAFTESGSTARRISRYRPKVPI 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489439883 403 YAFSPHRGTQARAAMFRGVYTVPFDPAAlPPGQVSQAAVDELLKRGLVEQGDWVILTKGDSYHTIGGTNGMKILHV 478
Cdd:COG0469 397 LALTPNERTARRLALVWGVYPVLVDDVE-STDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
4-475 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 549.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTDKR 83
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 84 IELKVGDKFTFSTAHPLTSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGPLSDHKGINRR 163
Cdd:TIGR01064 81 VKLKKGDKVIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 164 GGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESG-GTAWLVAKIERAEAVANdevLDELIRASD 242
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDN---IDEIAEASD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 243 AVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAESAAG 322
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 323 SYPIEAVQAMARICIGAEKHPTGKTSS---HRIGHSFTRCDESIALAAMYTANHFpGVKAIIALTESGYTPLIMSRIRSS 399
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTNFndrKNSDPKPSTITEAIALSAVEAAEKL-DAKAIVVLTESGRTARLLSKYRPN 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489439883 400 VPIYAFSPHRGTQARAAMFRGVYTVPFDPAALPPGQVSQAAVDELLKRGLVEQGDWVILTKGDSYHTIGGTNGMKI 475
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFLVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
4-478 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 529.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTD-K 82
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGgK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 83 RIELKVGDKFTFSTAHPLTSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRV-DTQTANELHCTVLIGGPLSDHKGIN 161
Cdd:cd00288 82 DISLKAGDKFLVTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVlSKDDDKTLVCEVLNGGVLGSRKGVN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 162 RRGGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESGGTAWLVAKIERAEAVANdevLDELIRAS 241
Cdd:cd00288 162 LPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNN---FDEILEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 242 DAVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAESAA 321
Cdd:cd00288 239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 322 GSYPIEAVQAMARICIGAEKHPTGKTSSHRIGHSFTRC---DESIALAAMYTANHFpGVKAIIALTESGYTPLIMSRIRS 398
Cdd:cd00288 319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPtstTEAVAMSAVRAAFEL-GAKAIVVLTTSGRTARLVSKYRP 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 399 SVPIYAFSPHRGTQARAAMFRGVYTVPFDPAalPPGQVS------QAAVDELLKRGLVEQGDWVILTKGDSYHTiGGTNG 472
Cdd:cd00288 398 NAPIIAVTRNEQTARQLHLYRGVYPVLFEEP--KPGWQEdtdarlKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNT 474
|
....*.
gi 489439883 473 MKILHV 478
Cdd:cd00288 475 MRILTV 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
4-341 |
2.01e-144 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 417.54 E-value: 2.01e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTD-- 81
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDgk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 82 KRIELKVGDKFTFSTAHPL-TSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRV-DTQTANELHCTVLIGGPLSDHKG 159
Cdd:pfam00224 82 KDIELKAGDEMIVSTDAKYkGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVlSKDDDKTLVVEVLNGGVIGSRKG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 160 INRRGGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESGGTAWLVAKIERAEAVANdevLDELIR 239
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNN---FDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 240 ASDAVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAES 319
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340
....*....|....*....|..
gi 489439883 320 AAGSYPIEAVQAMARICIGAEK 341
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEK 340
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-469 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 780.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 1 MTVRRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFT 80
Cdd:PRK05826 1 RMLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 81 DKRIELKVGDKFTFSTAhPLTSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGPLSDHKGI 160
Cdd:PRK05826 81 EGKITLKTGDKFTLDTD-QKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 161 NRRGGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESGG-TAWLVAKIERAEAVANdevLDELIR 239
Cdd:PRK05826 160 NIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVDN---IDEIIE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 240 ASDAVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAES 319
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 320 AAGSYPIEAVQAMARICIGAEKHPTGKTSSHRIGHSFTRCDESIALAAMYTANHFPGVKAIIALTESGYTPLIMSRIRSS 399
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPG 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 400 VPIYAFSPHRGTQARAAMFRGVYTVPFDPAAlPPGQVSQAAVDELLKRGLVEQGDWVILTKGDSYHTIGG 469
Cdd:PRK05826 397 APIFAVTRDEKTQRRLALYRGVYPVLFDSAA-DTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAGG 465
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
4-478 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 734.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTDKR 83
Cdd:COG0469 3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 84 IELKVGDKFTFSTAHplTSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGPLSDHKGINRR 163
Cdd:COG0469 83 VELKKGDTFTLTTDD--VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 164 GGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESGGTAWLVAKIERAEAVANdevLDELIRASDA 243
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVEN---LDEIIEASDG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 244 VMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAESAAGS 323
Cdd:COG0469 238 IMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGK 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 324 YPIEAVQAMARICIGAEKHPTGKTSSHRI-GHSFTRCDESIALAAMYTANHFpGVKAIIALTESGYTPLIMSRIRSSVPI 402
Cdd:COG0469 318 YPVEAVETMARIAEEAEKSLDYRRILDRLrDEPERTITDAIARAAVELAEDL-GAKAIVAFTESGSTARRISRYRPKVPI 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489439883 403 YAFSPHRGTQARAAMFRGVYTVPFDPAAlPPGQVSQAAVDELLKRGLVEQGDWVILTKGDSYHTIGGTNGMKILHV 478
Cdd:COG0469 397 LALTPNERTARRLALVWGVYPVLVDDVE-STDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
4-475 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 549.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTDKR 83
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 84 IELKVGDKFTFSTAHPLTSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGPLSDHKGINRR 163
Cdd:TIGR01064 81 VKLKKGDKVIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 164 GGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESG-GTAWLVAKIERAEAVANdevLDELIRASD 242
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDN---IDEIAEASD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 243 AVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAESAAG 322
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 323 SYPIEAVQAMARICIGAEKHPTGKTSS---HRIGHSFTRCDESIALAAMYTANHFpGVKAIIALTESGYTPLIMSRIRSS 399
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTNFndrKNSDPKPSTITEAIALSAVEAAEKL-DAKAIVVLTESGRTARLLSKYRPN 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489439883 400 VPIYAFSPHRGTQARAAMFRGVYTVPFDPAALPPGQVSQAAVDELLKRGLVEQGDWVILTKGDSYHTIGGTNGMKI 475
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFLVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
4-478 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 529.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTD-K 82
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGgK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 83 RIELKVGDKFTFSTAHPLTSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRV-DTQTANELHCTVLIGGPLSDHKGIN 161
Cdd:cd00288 82 DISLKAGDKFLVTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVlSKDDDKTLVCEVLNGGVLGSRKGVN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 162 RRGGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESGGTAWLVAKIERAEAVANdevLDELIRAS 241
Cdd:cd00288 162 LPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNN---FDEILEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 242 DAVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAESAA 321
Cdd:cd00288 239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 322 GSYPIEAVQAMARICIGAEKHPTGKTSSHRIGHSFTRC---DESIALAAMYTANHFpGVKAIIALTESGYTPLIMSRIRS 398
Cdd:cd00288 319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPtstTEAVAMSAVRAAFEL-GAKAIVVLTTSGRTARLVSKYRP 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 399 SVPIYAFSPHRGTQARAAMFRGVYTVPFDPAalPPGQVS------QAAVDELLKRGLVEQGDWVILTKGDSYHTiGGTNG 472
Cdd:cd00288 398 NAPIIAVTRNEQTARQLHLYRGVYPVLFEEP--KPGWQEdtdarlKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNT 474
|
....*.
gi 489439883 473 MKILHV 478
Cdd:cd00288 475 MRILTV 480
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
4-483 |
2.03e-156 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 452.84 E-value: 2.03e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTDKR 83
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 84 IELKVGDKFTFSTAHplTSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGPLSDHKGINRR 163
Cdd:PRK06247 85 VQLANGQTFRLDVDD--APGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 164 GGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLrdeSGGTAWLVAKIERAEAVANdevLDELIRASDA 243
Cdd:PRK06247 163 GTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKI---IGGRVPVMAKIEKPQAIDR---LEAIVEASDA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 244 VMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAESAAGS 323
Cdd:PRK06247 237 IMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGK 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 324 YPIEAVQAMARICIGAEKHPTGKTSSH--RIGHSFTRCDeSIALAAMYTANHFPgVKAIIALTESGYTPLIMSRIRSSVP 401
Cdd:PRK06247 317 YPVEAVRTMARIIRQVERDPTYPPLIHaqRPQPEATKRD-AISYAARDIAERLD-LAALVAYTSSGDTALRAARERPPLP 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 402 IYAFSPHRGTQARAAMFRGVYTVPFDPAALPPGQVSQAAvDELLKRGLVEQGDWVILTKGDSYHTIGGTNGMKILHVGDP 481
Cdd:PRK06247 395 ILALTPNPETARRLALTWGVHCVVVDDARDTDDMVRRAD-RIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGED 473
|
..
gi 489439883 482 LV 483
Cdd:PRK06247 474 DV 475
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-480 |
4.20e-155 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 453.61 E-value: 4.20e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 1 MTVRRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFT 80
Cdd:PRK06354 5 DLMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 81 DKRIELKVGDKFTFsTAHPLtSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDT--QTANELHCTVLIGGPLSDHK 158
Cdd:PRK06354 85 DGPIELKTGDEFIL-TSREV-LGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEvdKADGELHCKVLVGGVLSNKK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 159 GINRRGGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESGGTAW-LVAKIERAEAVANdevLDEL 237
Cdd:PRK06354 163 GVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIpIIAKIEKQEAIDN---IDAI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 238 IRASDAVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSA 317
Cdd:PRK06354 240 LELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 318 ESAAGSYPIEAVQAMARICIGAEKHPTGKTSSHRIGHSFTRCDESIALAAMYTANHFpGVKAIIALTESGYTPLIMSRIR 397
Cdd:PRK06354 320 ETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTTITNAISQAVSHIALQL-DAAAIVTLTKSGATARNVSKYR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 398 SSVPIYAFSPHRGTQARAAMFRGVYT--VPFDPAAlppGQVSQAAVDELLKRGLVEQGDWVILTKGDSYHTIGGTNGMKI 475
Cdd:PRK06354 399 PKTPILAVTPNESVARRLQLVWGVTPllVLDAPST---DETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKV 475
|
....*
gi 489439883 476 LHVGD 480
Cdd:PRK06354 476 HVVGA 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
4-341 |
2.01e-144 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 417.54 E-value: 2.01e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTD-- 81
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDgk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 82 KRIELKVGDKFTFSTAHPL-TSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRV-DTQTANELHCTVLIGGPLSDHKG 159
Cdd:pfam00224 82 KDIELKAGDEMIVSTDAKYkGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVlSKDDDKTLVVEVLNGGVIGSRKG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 160 INRRGGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESGGTAWLVAKIERAEAVANdevLDELIR 239
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNN---FDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 240 ASDAVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAES 319
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340
....*....|....*....|..
gi 489439883 320 AAGSYPIEAVQAMARICIGAEK 341
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEK 340
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
4-461 |
4.76e-117 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 352.05 E-value: 4.76e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTD-K 82
Cdd:PRK09206 2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGgN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 83 RIELKVGDKFTFSTAHPLTsGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGPLSDHKGINR 162
Cdd:PRK09206 82 DVSLKAGQTFTFTTDKSVV-GNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 163 RGGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESGGT-AWLVAKIERAEAVANdevLDELIRAS 241
Cdd:PRK09206 161 PGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEnIQIISKIENQEGLNN---FDEILEAS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 242 DAVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAESAA 321
Cdd:PRK09206 238 DGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAK 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 322 GSYPIEAVQAMARICIGAEKHPTGKTSShRIGHSFTRCDESIALAAMYTANHFpGVKAIIALTESGYTPLIMSRIRSSVP 401
Cdd:PRK09206 318 GKYPLEAVSIMATICERTDRVMNSRLES-NNDNRKLRITEAVCRGAVETAEKL-DAPLIVVATQGGKSARSVRKYFPDAT 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489439883 402 IYAFSPHRGTQARAAMFRGVYTVPFDpaalppgqvSQAAVDEL--------LKRGLVEQGDWVILTKG 461
Cdd:PRK09206 396 ILALTTNEKTARQLVLSKGVVPQLVK---------EIASTDDFyrlgkelaLQSGLAQKGDVVVMVSG 454
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
3-478 |
2.14e-102 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 315.76 E-value: 2.14e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 3 VRRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTD- 81
Cdd:PLN02461 20 RPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDg 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 82 KRIELKVGDKFTFSTAHPLtSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRV---DTQtANELHCTVLIGGPLSDHK 158
Cdd:PLN02461 100 KPVQLKQGQEITITTDYSI-KGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVlscDVE-AGTVRCRCENSAMLGERK 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 159 GINRRGGGLTAPALTEKDKQDI-KLAAEMDLDYLAVSFPRDAADMEYARQLRDESGGTAWLVAKIERAEAVANdevLDEL 237
Cdd:PLN02461 178 NVNLPGVVVDLPTLTEKDKEDIlQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDN---FDDI 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 238 IRASDAVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSA 317
Cdd:PLN02461 255 LAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSG 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 318 ESAAGSYPIEAVQAMARICIGAEKHPTGKTSSHRIGHSFT---RCDESIALAAMYTANhfpGVKA--IIALTESGYTPLI 392
Cdd:PLN02461 335 ETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPlpmSPLESLASSAVRTAN---KVKAslIVVLTRGGTTARL 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 393 MSRIRSSVPI------------YAFSPHRGTQARAAM-FRGVYTVPFDPAALPPGQVS-----QAAVDELLKRGLVEQGD 454
Cdd:PLN02461 412 VAKYRPAVPIlsvvvpeittdsFDWSCSDEAPARHSLiYRGLIPVLAEGSAKATDSESteeilEAAIEHAKKKGLCKPGD 491
|
490 500
....*....|....*....|....
gi 489439883 455 WVIltkgdSYHTIGGTNGMKILHV 478
Cdd:PLN02461 492 SVV-----ALHRIGGASVIKILTV 510
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
1-478 |
1.28e-98 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 305.92 E-value: 1.28e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 1 MTVRRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIRE-IAARHGRFVALLGDLQGPKIRIAKF 79
Cdd:PTZ00066 35 LRQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREaAKARPNANLGILLDTKGPEIRTGFL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 80 TD-KRIELKVGDKFTFSTAHPLTsGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGPLSDHK 158
Cdd:PTZ00066 115 KNhKPITLKEGQTLKITTDYTFL-GDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 159 GINRRGGGLTAPALTEKDKQDI-KLAAEMDLDYLAVSFPRDAADMEYARQLRDESGGTAWLVAKIERAEAVAN-DEVLDE 236
Cdd:PTZ00066 194 NMNLPGVKVELPVIGEKDKNDIlNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINfDEILAE 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 237 liraSDAVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLS 316
Cdd:PTZ00066 274 ----SDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLS 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 317 AESAAGSYPIEAVQAMARICIGAEK---HPTGKTSSHRIGHSFTRCDESIALAAMYTAnHFPGVKAIIALTESGYTPLIM 393
Cdd:PTZ00066 350 GETANGKFPVEAVNIMAKICFEAETcidYRVLYHAIHLAVPTPVSVQEAVARSAVETA-EDINAKLIIALTETGNTARLI 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 394 SRIRSSVPIYAFSPHRGTQARAAMFRGVYTVPFdPAALPPGQVSQAAVDELLKRGLVEQGDWVILTKGDSYHTIGGTNGM 473
Cdd:PTZ00066 429 SKYRPSCTILALSASPSVVKSLSVARGVTTYVV-NSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLM 507
|
....*
gi 489439883 474 KILHV 478
Cdd:PTZ00066 508 KVVKI 512
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
4-460 |
1.44e-94 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 297.61 E-value: 1.44e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAAR-HGRFVALLGDLQGPKIRIAKFTdK 82
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQsKDNVIAIMLDTKGPEVRSGDLP-Q 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 83 RIELKVGDKFTFSTAHPLtsGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGPLSDHKGINR 162
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRGV--STEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 163 RGGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESGGTAWLVAKIERAEAVANdevLDELIRASD 242
Cdd:PLN02623 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPN---LHSIITASD 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 243 AVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAESAAG 322
Cdd:PLN02623 344 GAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHG 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 323 SYPIEAVQAMARICIGAEKHPTGKTSSHRIGHSF-TRCDESIALAAMYTANHFPgvKAIIALTESGYTPLIMSRIRSSVP 401
Cdd:PLN02623 424 KFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFkNHMSEMFAFHATMMANTLG--TSIIVFTRTGFMAILLSHYRPSGT 501
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489439883 402 IYAFSPHRGTQARAAMFRGVYTV--PFDPAAlppGQVSQAAVDELLKRGLVEQGDWVILTK 460
Cdd:PLN02623 502 IFAFTNEKRIQQRLALYQGVCPIymQFSDDA---EETFARALSLLLNKGMVKEGEEVALVQ 559
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
1-340 |
1.87e-90 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 279.52 E-value: 1.87e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 1 MTVRRtkiVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARhgrfVALLGDLQGPKIRIAKFT 80
Cdd:PRK06739 1 MTIDR---ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----IKILGDVQGPKIRLGEIK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 81 DKRIELKVGDKFTFSTaHPLTsGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGPLSDHKGI 160
Cdd:PRK06739 74 GEQITLQAGDSFILHT-QPVT-GSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 161 NRRGGGLTAPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQLRDESGGTA-WLVAKIERAEAVANdevLDELIR 239
Cdd:PRK06739 152 NLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIEN---FQDICK 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 240 ASDAVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAES 319
Cdd:PRK06739 229 EADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAES 308
|
330 340
....*....|....*....|.
gi 489439883 320 AAGSYPIEAVQAMARICIGAE 340
Cdd:PRK06739 309 ASGEHPIESVSTLRLVSEFAE 329
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
1-457 |
1.96e-83 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 266.61 E-value: 1.96e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 1 MTVRRTKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKF- 79
Cdd:PLN02762 22 RSTRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLg 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 80 --TDKRIElkVGDKFTFSTAHPLTSGNQQIVGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGPL--- 154
Cdd:PLN02762 102 gaSSAKAE--DGEEWTFTVRKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLlpr 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 155 ------SDHKGINRRGGGLtaPALTEKDKQDIKLAAEMDLDYLAVSFPRDAADMEYARQL--RDESGGTAWLVAKIERAE 226
Cdd:PLN02762 180 anltfwRDGSLVRERNAML--PTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYiaARSRDSDIGVIAKIESLD 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 227 AVANdevLDELIRASDAVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAV 306
Cdd:PLN02762 258 SLKN---LEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAV 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 307 LDYTDAVMLSAESAAGSYPIEAVQA-------MARICIGAEKHptGKTSSHRIGHSFT-RCDESIALAAMYTANHFpGVK 378
Cdd:PLN02762 335 RQRADALMLSGESAMGLYPEKALSVlrsvslrMELWSREEKRH--EALELPQLSSSLSdRISEEICNSAAKMANNL-GVD 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 379 AIIALTESGYTPLIMSRIRSSVPIYAFSPHRGTQARAAMFRGVYTVPFDPAALPPGQVSQAAvdELLK-RGLVEQGDWVI 457
Cdd:PLN02762 412 AIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTF--SLLKaRGMIKSGDLVI 489
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
30-478 |
2.38e-79 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 254.20 E-value: 2.38e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 30 LDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTDKRIELKVGDKfTFSTAHPLTS--GNQQI 107
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGAT-CYVTTDPAFAdkGTKDK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 108 VGIDYPDLVKDCGVGDELLLDDGRVVMRV----DTQTaneLHCTVLIGGPLSDHKGINRRGGGLTAPALTEKDKQDIKLA 183
Cdd:PTZ00300 80 FYIDYQNLSKVVRPGGYIYIDDGILILHVqsheDEQT---LKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 184 AEMDLDYLAVSFPRDAADMEYARQLRDESGGTAWLVAKIERAEAVANdevLDELIRASDAVMVARGDLGVEIGDAELVGV 263
Cdd:PTZ00300 157 VEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQN---IDSIIEESDGIMVARGDLGVEIPAEKVVVA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 264 QKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAESAAGSYPIEAVQAMARICIGAEKhp 343
Cdd:PTZ00300 234 QKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS-- 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 344 tgKTSSHRIGHSFTR-------CDESIALAAMYTAnHFPGVKAIIALTESGYTPLIMSRIRSSVPIYAFSPHRGTQARAA 416
Cdd:PTZ00300 312 --AVNEYVFFNSIKKlqpipmsAEEAVCSSAVNSV-YETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLN 388
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489439883 417 MFRGVYTVPFDPAAL----PPGQVSQAAVDELLKRGLVEQGDWVILTKGDsyHTIGG-TNGMKILHV 478
Cdd:PTZ00300 389 ITQGVESVFFDAERLghdeGKEQRVAMGVGFAKSKGYVQSGDLMVVVHAD--HKVKGyANQTRIILV 453
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
6-480 |
2.22e-67 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 224.93 E-value: 2.22e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 6 TKIVATLGPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFTDKRIE 85
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 86 LKVGDKFTFsTAHPLTSGNQQIVGIDYPDLVKDCGVGDELLL--------DDGRVVMRVDTQTANELHCTV----LIGGP 153
Cdd:PLN02765 110 LKAGNTVTL-TPDQSKEASSEVLPINFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGDDVVCTVknsaTLAGS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 154 L----SDHKGINrrgggltAPALTEKDKQDIK-LAAEMDLDYLAVSFPRDAADMEYARQLRDESGGT-AWLVAKIERAEA 227
Cdd:PLN02765 189 LftlhVSQVRID-------LPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSqTQIFAKIENVEG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 228 VANdevLDELIRASDAVMVARGDLGVEIgDAELVGV-QKRIILHARRHNKAVIVaTQMMESMISSPMPTRAEVSDVANAV 306
Cdd:PLN02765 262 LTH---FDEILQEADGIILSRGNLGIDL-PPEKVFLfQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAV 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 307 LDYTDAVMLSAESAAGSYPIEAVQAMARICIGAEK------------HPTGKTSSHRighsftrcdESIALAAMYTANHf 374
Cdd:PLN02765 337 LDGADAILLGAETLRGLYPVETISTVGRICAEAEKvfnqdlyfkktvKYVGEPMSHL---------ESIASSAVRAAIK- 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 375 pgVKA--IIALTESGYTPLIMSRIRSSVPIYAFS-PHRGT-----------QARAAM-FRGVY------TVPFDPAALPP 433
Cdd:PLN02765 407 --VKAsvIIVFTSSGRAARLIAKYRPTMPVLSVViPRLKTnqlkwsftgafQARQCLiVRGLFpmladpRHSAESTSATN 484
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 489439883 434 GQVSQAAVDELLKRGLVEQGDWVILtkgdsYHTIGGTNGMKILHVGD 480
Cdd:PLN02765 485 ESVLKVALDHGKAAGVIKSHDRVVV-----CQKVGDSSVVKIIELDD 526
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
4-355 |
2.71e-44 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 162.49 E-value: 2.71e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATL-GPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIRIAKFT-- 80
Cdd:PRK08187 133 RRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVAgp 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 81 DKRIELKVGDKFTFSTAHPLTSGNQQI--VGIDYPDLVKDCGVGDELLLDDGRVVMRVDTQTANELHCTVLIGGP----L 154
Cdd:PRK08187 213 LGKTRLYTGDRLALVAQGPPRRIDEEHfqVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTHARPkglkL 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 155 SDHKGINRRGGGLTAPALTEKDKQDIKLAAEmDLDYLAVSFPRDAADMEYARQLRDESGGTAW----LVAKIERAEAVAN 230
Cdd:PRK08187 293 KPEKGLNFPDTALDLPALTEKDRADLDFVAR-HADLVGYSFVQSPGDVEALQAALAARRPDDWrklgLVLKIETPRAVAN 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 231 devLDELIRASD-----AVMVARGDLGVEIGDAELVGVQKRIILHARRHNKAVIVATQMMESMISSPMPTRAEVSDVANA 305
Cdd:PRK08187 372 ---LPELIVQAAgrqpfGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA 448
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 489439883 306 vlDYTDAVMLSaesaAGSYPIEAVQAMARICIGAEKHPTGKTSSHRIGHS 355
Cdd:PRK08187 449 --ARAECVMLN----KGPYLVEAVTFLDDLLARMDGHQHKKTPQLRALRS 492
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
4-335 |
3.27e-37 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 144.32 E-value: 3.27e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 4 RRTKIVATL-GPASNSPEVIEQLILSGLDVARLNFSHGTPDEHKARARLIREIAARHGRFVALLGDLQGPKIR---IA-- 77
Cdd:PRK14725 139 RPTRIMVTLpTEAADDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRtgpIApg 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 78 ---------------------------------------------------------KFTDKR----------------- 83
Cdd:PRK14725 219 prviklrptrdalgrvltparlwltasespppspppgpvglpvdpewlarlepgdelRFTDARgkkrkltvtevddegvl 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 84 ----------------------------------IELKVGDKFTFST----AHPLTSGNQQI-VGIDYPDLVKDCGVGDE 124
Cdd:PRK14725 299 aegsqtaylangtllrlgrhdstrvgglppveqkLRLKVGDRLVLTRddapGDPAQGDAPPArISCTLPEAFRAARVGER 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 125 LLLDDGRVVMRVDTQTANELHCTVLIGGP----LSDHKGINRRGGGLTAPALTEKDKQDIKLAAEMdLDYLAVSFPRDAA 200
Cdd:PRK14725 379 VWFDDGKIGAVVVKVEADEVELRITHARPggskLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALSFVRSPE 457
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 201 DMEYARQ-LRDESGGTAWLVAKIERAEAVAN-DEVLDELIRASD-AVMVARGDLGVEIGDAELVGVQKRIILHARRHNKA 277
Cdd:PRK14725 458 DVRLLLDaLEKLGADDLGVVLKIETRRAFENlPRILLEAMRHPRfGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVP 537
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 489439883 278 VIVATQMMESMISSPMPTRAEVSDVANAVldYTDAVMLSaesaAGSYPIEAVQAMARI 335
Cdd:PRK14725 538 VIWATQVLESLAKKGLPSRAEITDAAMAL--RAECVMLN----KGPHIVEAVRVLDDI 589
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
361-476 |
6.95e-36 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 128.75 E-value: 6.95e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 361 ESIALAAMYTANHFpGVKAIIALTESGYTPLIMSRIRSSVPIYAFSPHRGTQARAAMFRGVYTVPFDPAALPPGQVsQAA 440
Cdd:pfam02887 1 EAIAHAAVEAAEEL-GAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEML-RRA 78
|
90 100 110
....*....|....*....|....*....|....*.
gi 489439883 441 VDELLKRGLVEQGDWVILTKGDSYHTIGGTNGMKIL 476
Cdd:pfam02887 79 VKVAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
276-483 |
3.30e-34 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 130.79 E-value: 3.30e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 276 KAVIVATQMMESMISSPMPTRAEVSDVANAVLDYTDAVMLSAESAAGSYPIEAVQAMARICIGAEK-HPTGKTSSHRIGH 354
Cdd:COG3848 7 KPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEdLEYREQRVPRAKE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489439883 355 SFTRCDESIALAAMYTAnHFPGVKAIIALTESGYTPLIMSRIRSSVPIYAFSPHRGTQARAAMFRGVYTVPFDPAAlPPG 434
Cdd:COG3848 87 SSTTITDAISHAVATTA-ADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEESA-STD 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 489439883 435 QVSQAAVDELLKRGLVEQGDWVILTKGDSYHTIGGTNGMKILHVGDPLV 483
Cdd:COG3848 165 EMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGDVLA 213
|
|
| |
