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Conserved domains on  [gi|489495177|ref|WP_003400094|]
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MULTISPECIES: pore-forming CpnT exporter EsxE [Mycobacterium]

Protein Classification

WXG100 family type VII secretion target( domain architecture ID 10008875)

WXG100 family type VII secretion target such as mycobacterial ESAT-6-like protein EsxB, also called CFP-10, which is a secreted protein that acts as a strong host T-cell antigen and is involved in the translocation of bacteria from the host phagolysosome to the host cytoplasm

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EsxA COG4842
Secreted virulence factor YukE/EsxA, WXG100 family [Defense mechanisms];
1-90 7.97e-03

Secreted virulence factor YukE/EsxA, WXG100 family [Defense mechanisms];


:

Pssm-ID: 443870  Cd Length: 93  Bit Score: 32.66  E-value: 7.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489495177  1 MDPTVLADAVARMAEFGRHVEELVAEIESLVTRLHVTWTGEGAAAHAEAQRHWAAGEAMMRQALAQLTAAGQSAHANYTG 80
Cdd:COG4842   3 VDPEALRAAAGRFGAAAGELQALLDDLRSQLAALQSSWEGDAATAFQAAQAQWDQAATKLNQALEDIAQALRQAADAYEE 82

                        90
                ....*....|
gi 489495177 81 AMATNLGMWS 90
Cdd:COG4842  83 AEQANAALFG 92
 
Name Accession Description Interval E-value
EsxA COG4842
Secreted virulence factor YukE/EsxA, WXG100 family [Defense mechanisms];
1-90 7.97e-03

Secreted virulence factor YukE/EsxA, WXG100 family [Defense mechanisms];


Pssm-ID: 443870  Cd Length: 93  Bit Score: 32.66  E-value: 7.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489495177  1 MDPTVLADAVARMAEFGRHVEELVAEIESLVTRLHVTWTGEGAAAHAEAQRHWAAGEAMMRQALAQLTAAGQSAHANYTG 80
Cdd:COG4842   3 VDPEALRAAAGRFGAAAGELQALLDDLRSQLAALQSSWEGDAATAFQAAQAQWDQAATKLNQALEDIAQALRQAADAYEE 82

                        90
                ....*....|
gi 489495177 81 AMATNLGMWS 90
Cdd:COG4842  83 AEQANAALFG 92
 
Name Accession Description Interval E-value
EsxA COG4842
Secreted virulence factor YukE/EsxA, WXG100 family [Defense mechanisms];
1-90 7.97e-03

Secreted virulence factor YukE/EsxA, WXG100 family [Defense mechanisms];


Pssm-ID: 443870  Cd Length: 93  Bit Score: 32.66  E-value: 7.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489495177  1 MDPTVLADAVARMAEFGRHVEELVAEIESLVTRLHVTWTGEGAAAHAEAQRHWAAGEAMMRQALAQLTAAGQSAHANYTG 80
Cdd:COG4842   3 VDPEALRAAAGRFGAAAGELQALLDDLRSQLAALQSSWEGDAATAFQAAQAQWDQAATKLNQALEDIAQALRQAADAYEE 82

                        90
                ....*....|
gi 489495177 81 AMATNLGMWS 90
Cdd:COG4842  83 AEQANAALFG 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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