NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489499454|ref|WP_003404362|]
View 

MULTISPECIES: sensor domain-containing protein [Mycobacterium]

Protein Classification

sensor domain-containing protein( domain architecture ID 10623922)

sensor domain-containing protein of unknown function similar to the extracellular domain of Mycobacterium PknH

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PknH_C pfam14032
PknH-like extracellular domain; This domain is functionally uncharacterized. It is found as ...
 36-212 1.11e-22

PknH-like extracellular domain; This domain is functionally uncharacterized. It is found as the periplasmic domain of the bacterial protein kinase PknH. The domain is also found in isolation in numerous proteins, for example the lipoproteins lpqQ, lprH, lppH and lpqA from M. tuberculosis. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 268 amino acids in length. There are two completely conserved C residues that are likely to form a disulphide bond. A second pair of cysteines are less well conserved probably form a second disulphide bond. It seems likely that this domain functions to bind some as yet unknown ligand.


:

Pssm-ID: 433660  Cd Length: 188  Bit Score: 90.56  E-value: 1.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489499454   36 PPTSRVDSLIVSIEDVRRIANYEELAAHFqtDLREPPEADTNV-PGPCRVVGSSDRTF---GTDWSEFRSAGYhgvtddl 111
Cdd:pfam14032   1 VPAAALGGLLLTPAEVAAIVGAPDMSVTE--ELTTPPDDSGSVdPPECLGAAGAGQPSvyaGSGWTAVRGQTL------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489499454  112 RPGGPVMVETVSQAIALYPDPSTARGVFHRLESSLAECAGL-------HDPYFDFILDRPDAS---------TVRIGAAG 175
Cdd:pfam14032  72 SDPGDDGAHLVGQAVVAFPSADAAQAFFDSLVAQWRGCAGQtttttdpDGPTYDWTVGDVSADdgvltatvtQEGGDGWR 151

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 489499454  176 WSHVYRLKSSVFISVGVLGIEPAEPIANVILQTISDR 212
Cdd:pfam14032 152 CQRALAVRNNVVVDVAVCGFGNGGDAAVEIADAIADK 188
 
Name Accession Description Interval E-value
PknH_C pfam14032
PknH-like extracellular domain; This domain is functionally uncharacterized. It is found as ...
 36-212 1.11e-22

PknH-like extracellular domain; This domain is functionally uncharacterized. It is found as the periplasmic domain of the bacterial protein kinase PknH. The domain is also found in isolation in numerous proteins, for example the lipoproteins lpqQ, lprH, lppH and lpqA from M. tuberculosis. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 268 amino acids in length. There are two completely conserved C residues that are likely to form a disulphide bond. A second pair of cysteines are less well conserved probably form a second disulphide bond. It seems likely that this domain functions to bind some as yet unknown ligand.


Pssm-ID: 433660  Cd Length: 188  Bit Score: 90.56  E-value: 1.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489499454   36 PPTSRVDSLIVSIEDVRRIANYEELAAHFqtDLREPPEADTNV-PGPCRVVGSSDRTF---GTDWSEFRSAGYhgvtddl 111
Cdd:pfam14032   1 VPAAALGGLLLTPAEVAAIVGAPDMSVTE--ELTTPPDDSGSVdPPECLGAAGAGQPSvyaGSGWTAVRGQTL------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489499454  112 RPGGPVMVETVSQAIALYPDPSTARGVFHRLESSLAECAGL-------HDPYFDFILDRPDAS---------TVRIGAAG 175
Cdd:pfam14032  72 SDPGDDGAHLVGQAVVAFPSADAAQAFFDSLVAQWRGCAGQtttttdpDGPTYDWTVGDVSADdgvltatvtQEGGDGWR 151

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 489499454  176 WSHVYRLKSSVFISVGVLGIEPAEPIANVILQTISDR 212
Cdd:pfam14032 152 CQRALAVRNNVVVDVAVCGFGNGGDAAVEIADAIADK 188
 
Name Accession Description Interval E-value
PknH_C pfam14032
PknH-like extracellular domain; This domain is functionally uncharacterized. It is found as ...
 36-212 1.11e-22

PknH-like extracellular domain; This domain is functionally uncharacterized. It is found as the periplasmic domain of the bacterial protein kinase PknH. The domain is also found in isolation in numerous proteins, for example the lipoproteins lpqQ, lprH, lppH and lpqA from M. tuberculosis. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 268 amino acids in length. There are two completely conserved C residues that are likely to form a disulphide bond. A second pair of cysteines are less well conserved probably form a second disulphide bond. It seems likely that this domain functions to bind some as yet unknown ligand.


Pssm-ID: 433660  Cd Length: 188  Bit Score: 90.56  E-value: 1.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489499454   36 PPTSRVDSLIVSIEDVRRIANYEELAAHFqtDLREPPEADTNV-PGPCRVVGSSDRTF---GTDWSEFRSAGYhgvtddl 111
Cdd:pfam14032   1 VPAAALGGLLLTPAEVAAIVGAPDMSVTE--ELTTPPDDSGSVdPPECLGAAGAGQPSvyaGSGWTAVRGQTL------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489499454  112 RPGGPVMVETVSQAIALYPDPSTARGVFHRLESSLAECAGL-------HDPYFDFILDRPDAS---------TVRIGAAG 175
Cdd:pfam14032  72 SDPGDDGAHLVGQAVVAFPSADAAQAFFDSLVAQWRGCAGQtttttdpDGPTYDWTVGDVSADdgvltatvtQEGGDGWR 151

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 489499454  176 WSHVYRLKSSVFISVGVLGIEPAEPIANVILQTISDR 212
Cdd:pfam14032 152 CQRALAVRNNVVVDVAVCGFGNGGDAAVEIADAIADK 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH