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Conserved domains on  [gi|489500033|ref|WP_003404940|]
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MULTISPECIES: peptide chain release factor 1 [Pseudomonas]

Protein Classification

peptide chain release factor 1( domain architecture ID 11415460)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

Gene Ontology:  GO:0016149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 4-359 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 698.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033   4 SLLNKLDVLSDRFEELTALLGDAEVISDQTRFRAYSREYAEVEPVVALYAQLLRVQGDLEGAQALLKD-SDPDMREMAVE 82
Cdd:COG0216    1 SMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEeSDPEMREMAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  83 EVRETKQQLVELEAQLQRMLLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEILSENEGEHGGYK 162
Cdd:COG0216   81 ELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 163 EVIARVEGDSVYGKLKFESGAHRVQRVPETESQGRIHTSACTVAVLPEPDEQQaIEINPADLRVDTYRSSGAGGQHVNKT 242
Cdd:COG0216  161 EVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVD-VEINPKDLRIDTFRSSGAGGQHVNTT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 243 DSAIRITHLPSGIVVECQEERSQHKNRARAMSWLSAKLNDQQTSAAANAIASERKLLVGSGDRSERIRTYNFPQGRVTDH 322
Cdd:COG0216  240 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDH 319

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 489500033 323 RVNLTLYSLDEVLAGGVDAVIEPLLAEYQADQLAALG 359
Cdd:COG0216  320 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 4-359 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 698.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033   4 SLLNKLDVLSDRFEELTALLGDAEVISDQTRFRAYSREYAEVEPVVALYAQLLRVQGDLEGAQALLKD-SDPDMREMAVE 82
Cdd:COG0216    1 SMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEeSDPEMREMAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  83 EVRETKQQLVELEAQLQRMLLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEILSENEGEHGGYK 162
Cdd:COG0216   81 ELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 163 EVIARVEGDSVYGKLKFESGAHRVQRVPETESQGRIHTSACTVAVLPEPDEQQaIEINPADLRVDTYRSSGAGGQHVNKT 242
Cdd:COG0216  161 EVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVD-VEINPKDLRIDTFRSSGAGGQHVNTT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 243 DSAIRITHLPSGIVVECQEERSQHKNRARAMSWLSAKLNDQQTSAAANAIASERKLLVGSGDRSERIRTYNFPQGRVTDH 322
Cdd:COG0216  240 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDH 319

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 489500033 323 RVNLTLYSLDEVLAGGVDAVIEPLLAEYQADQLAALG 359
Cdd:COG0216  320 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 2-360 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 690.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033   2 KASLLNKLDVLSDRFEELTALLGDAEVISDQTRFRAYSREYAEVEPVVALYAQLLRVQGDLEGAQALLKD-SDPDMREMA 80
Cdd:PRK00591   1 KPSMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEeSDPEMREMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  81 VEEVRETKQQLVELEAQLQRMLLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEILSENEGEHGG 160
Cdd:PRK00591  81 KEELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 161 YKEVIARVEGDSVYGKLKFESGAHRVQRVPETESQGRIHTSACTVAVLPEPDEqQAIEINPADLRVDTYRSSGAGGQHVN 240
Cdd:PRK00591 161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEE-VEVEINPKDLRIDTFRSSGAGGQHVN 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 241 KTDSAIRITHLPSGIVVECQEERSQHKNRARAMSWLSAKLNDQQTSAAANAIASERKLLVGSGDRSERIRTYNFPQGRVT 320
Cdd:PRK00591 240 TTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVT 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 489500033 321 DHRVNLTLYSLDEVLAGGVDAVIEPLLAEYQADQLAALGE 360
Cdd:PRK00591 320 DHRINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALGE 359
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-360 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 578.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033    1 MKASLLNKLDVLSDRFEELTALLGDAEVISDQTRFRAYSREYAEVEPVVALYAQLLRVQGDLEGAQALLKDSDPDMREMA 80
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEESDPEMREMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033   81 VEEVRETKQQLVELEAQLQRMLLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEILSENEGEHGG 160
Cdd:TIGR00019  81 KEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  161 YKEVIARVEGDSVYGKLKFESGAHRVQRVPETESQGRIHTSACTVAVLPEPDEQQaIEINPADLRVDTYRSSGAGGQHVN 240
Cdd:TIGR00019 161 YKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVE-VDINPADLRIDTFRSSGAGGQHVN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  241 KTDSAIRITHLPSGIVVECQEERSQHKNRARAMSWLSAKLNDQQTSAAANAIASERKLLVGSGDRSERIRTYNFPQGRVT 320
Cdd:TIGR00019 240 TTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVT 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 489500033  321 DHRVNLTLYSLDEVLAGGVDAVIEPLLAEYQADQLAALGE 360
Cdd:TIGR00019 320 DHRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAALSE 359
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 12-205 1.08e-113

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 328.57  E-value: 1.08e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033   12 LSDRFEELTALLGDAEVISDQTRFRAYSREYAEVEPVVALYAQLLRVQGDLEGAQALLKDsdPDMREMAVEEVRETKQQL 91
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLED--PELAELAEEELEELEKRL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033   92 VELEAQLQRMLLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEILSENEGEHGGYKEVIARVEGD 171
Cdd:pfam03462  79 EELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGE 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 489500033  172 SVYGKLKFESGAHRVQRVPETESQGRIHTSACTV 205
Cdd:pfam03462 159 GAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
66-180 9.11e-61

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 190.75  E-value: 9.11e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033    66 QALLKDSDPDMREMAVEEVRETKQQLV-ELEAQLQRMLLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERR 144
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEAELEeELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 489500033   145 GWRVEILSENEGEHGGYKEVIARVEGDSVYGKLKFE 180
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 4-359 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 698.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033   4 SLLNKLDVLSDRFEELTALLGDAEVISDQTRFRAYSREYAEVEPVVALYAQLLRVQGDLEGAQALLKD-SDPDMREMAVE 82
Cdd:COG0216    1 SMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEeSDPEMREMAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  83 EVRETKQQLVELEAQLQRMLLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEILSENEGEHGGYK 162
Cdd:COG0216   81 ELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 163 EVIARVEGDSVYGKLKFESGAHRVQRVPETESQGRIHTSACTVAVLPEPDEQQaIEINPADLRVDTYRSSGAGGQHVNKT 242
Cdd:COG0216  161 EVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVD-VEINPKDLRIDTFRSSGAGGQHVNTT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 243 DSAIRITHLPSGIVVECQEERSQHKNRARAMSWLSAKLNDQQTSAAANAIASERKLLVGSGDRSERIRTYNFPQGRVTDH 322
Cdd:COG0216  240 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDH 319

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 489500033 323 RVNLTLYSLDEVLAGGVDAVIEPLLAEYQADQLAALG 359
Cdd:COG0216  320 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 2-360 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 690.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033   2 KASLLNKLDVLSDRFEELTALLGDAEVISDQTRFRAYSREYAEVEPVVALYAQLLRVQGDLEGAQALLKD-SDPDMREMA 80
Cdd:PRK00591   1 KPSMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEeSDPEMREMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  81 VEEVRETKQQLVELEAQLQRMLLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEILSENEGEHGG 160
Cdd:PRK00591  81 KEELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 161 YKEVIARVEGDSVYGKLKFESGAHRVQRVPETESQGRIHTSACTVAVLPEPDEqQAIEINPADLRVDTYRSSGAGGQHVN 240
Cdd:PRK00591 161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEE-VEVEINPKDLRIDTFRSSGAGGQHVN 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 241 KTDSAIRITHLPSGIVVECQEERSQHKNRARAMSWLSAKLNDQQTSAAANAIASERKLLVGSGDRSERIRTYNFPQGRVT 320
Cdd:PRK00591 240 TTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVT 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 489500033 321 DHRVNLTLYSLDEVLAGGVDAVIEPLLAEYQADQLAALGE 360
Cdd:PRK00591 320 DHRINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALGE 359
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-360 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 578.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033    1 MKASLLNKLDVLSDRFEELTALLGDAEVISDQTRFRAYSREYAEVEPVVALYAQLLRVQGDLEGAQALLKDSDPDMREMA 80
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEESDPEMREMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033   81 VEEVRETKQQLVELEAQLQRMLLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEILSENEGEHGG 160
Cdd:TIGR00019  81 KEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  161 YKEVIARVEGDSVYGKLKFESGAHRVQRVPETESQGRIHTSACTVAVLPEPDEQQaIEINPADLRVDTYRSSGAGGQHVN 240
Cdd:TIGR00019 161 YKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVE-VDINPADLRIDTFRSSGAGGQHVN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  241 KTDSAIRITHLPSGIVVECQEERSQHKNRARAMSWLSAKLNDQQTSAAANAIASERKLLVGSGDRSERIRTYNFPQGRVT 320
Cdd:TIGR00019 240 TTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVT 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 489500033  321 DHRVNLTLYSLDEVLAGGVDAVIEPLLAEYQADQLAALGE 360
Cdd:TIGR00019 320 DHRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAALSE 359
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 12-205 1.08e-113

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 328.57  E-value: 1.08e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033   12 LSDRFEELTALLGDAEVISDQTRFRAYSREYAEVEPVVALYAQLLRVQGDLEGAQALLKDsdPDMREMAVEEVRETKQQL 91
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLED--PELAELAEEELEELEKRL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033   92 VELEAQLQRMLLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEILSENEGEHGGYKEVIARVEGD 171
Cdd:pfam03462  79 EELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGE 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 489500033  172 SVYGKLKFESGAHRVQRVPETESQGRIHTSACTV 205
Cdd:pfam03462 159 GAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 8-347 5.32e-90

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 274.34  E-value: 5.32e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033    8 KLDVLSDRFEELTALLGDAEVISDQTRFRAYSREYAEVEPVVALYAQLLRVQGDLEGAQALLK-DSDPDMREMAVEEVRE 86
Cdd:TIGR00020  24 DPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSELLELAVeEDDEETFNELDAELKA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033   87 TKQQLVELEaqLQRMLlpKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEILSENEGEHGGYKEVIA 166
Cdd:TIGR00020 104 LEKKLAELE--LRTML--SGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  167 RVEGDSVYGKLKFESGAHRVQRVPETESQGRIHTSACTVAVLPEPDEQQAIEINPADLRVDTYRSSGAGGQHVNKTDSAI 246
Cdd:TIGR00020 180 LIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAV 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  247 RITHLPSGIVVECQEERSQHKNRARAMSWLSAKLND---QQTSAAANAIASERKlLVGSGDrseRIRTYNF-PQGRVTDH 322
Cdd:TIGR00020 260 RITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYElemEKEQAEKDAKEGEKS-EIGWGS---QIRSYVLhPYSMVKDL 335

                         330       340
                  ....*....|....*....|....*
gi 489500033  323 RVNLTLYSLDEVLAGGVDAVIEPLL 347
Cdd:TIGR00020 336 RTGYETGNVQAVLDGDIDQFIEAYL 360
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 71-347 2.33e-75

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 235.32  E-value: 2.33e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  71 DSDPDMREMAVEEVRETKQQLVELEaqLQRMLLPKdpNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEI 150
Cdd:PRK08787  29 EQDEDTALAVIADLDKYQAHVEKLE--FQRMFSGQ--MDGANAFVDIQAGAGGTEAQDWAEILLRMYLRWAESRGWKTEL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 151 LSENEGEHGGYKEVIARVEGDSVYGKLKFESGAHRVQRVPETESQGRIHTSACTVAVLPEPDEQQAIEINPADLRVDTYR 230
Cdd:PRK08787 105 MEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEVDDNIEIDINPADLRTDVYR 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 231 SSGAGGQHVNKTDSAIRITHLPSGIVVECQEERSQHKNRARAMSWLSAKLND---QQTSAAANAI-ASERKLLVGSgdrs 306
Cdd:PRK08787 185 SSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYElevQKRNAEKDALeATKSDIGWGS---- 260

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 489500033 307 eRIRTYNFPQGRVTDHRVNLTLYSLDEVLAGGVDAVIEPLL 347
Cdd:PRK08787 261 -QIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVEASL 300
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 60-349 6.83e-71

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 224.76  E-value: 6.83e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  60 GDLEGAQALLKDSDPDMREMAVEEVRETKQQLVELEAqlqrmllpkDPNDgrnVFLEIRAGTGGDEAAIFSGDLFRMYSR 139
Cdd:PRK07342  49 GEEEGDKSIVEDAEKTIRDLKDEIDRRQIDALLSGEA---------DAND---TYLEVHAGAGGTESQDWASMLLRMYTR 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 140 YAERRGWRVEILSENEGEHGGYKEVIARVEGDSVYGKLKFESGAHRVQRVPETESQGRIHTSACTVAVLPEPDEQQAIEI 219
Cdd:PRK07342 117 WAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGVHRLVRISPYDSNARRHTSFASIWVYPVIDDNIEVDV 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 220 NPADLRVDTYRSSGAGGQHVNKTDSAIRITHLPSGIVVECQEERSQHKNRARAMSWLSAKLNDQQ---TSAAANAIASEr 296
Cdd:PRK07342 197 NESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKAWSMLRARLYEEElkkREEATNAAAAS- 275

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489500033 297 KLLVGSGdrsERIRTYNF-PQGRVTDHRVNLTLYSLDEVLAGGVDAVIEPLLAE 349
Cdd:PRK07342 276 KTDIGWG---HQIRSYVLqPYQLVKDLRTGVESTNPQDVLDGDLNEFMEAALAH 326
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 61-343 1.76e-69

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 220.45  E-value: 1.76e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  61 DLEGAQALLKDSDPDMREMAVEEVRETKQQLVELEAQLqrmlLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRY 140
Cdd:PRK05589  39 DIEVLCEMMSEEDDEMKKEIISEVKNIKEEIDRFKIET----LLSGEYDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRW 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 141 AERRGWRVEILSENEGEHGGYKEVIARVEGDSVYGKLKFESGAHRVQRVPETESQGRIHTSACTVAVLPEPDEQQAIEIN 220
Cdd:PRK05589 115 AEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLVRISPFNANGKRQTSFASVEVLPELTDDQDIEIR 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 221 PADLRVDTYRSSGAGGQHVNKTDSAIRITHLPSGIVVECQEERSQHKNRARAMSWLSAKLNDQQTSAAANAIASERKLLV 300
Cdd:PRK05589 195 SEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKMLKSKLVELKERAHKEKIEDLTGELK 274

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 489500033 301 GSGDRSErIRTYNF-PQGRVTDHRVNLTLYSLDEVLAGGVDAVI 343
Cdd:PRK05589 275 DMGWGSQ-IRSYVFhPYNLVKDHRTGVETSNVDSVMDGDIDNFI 317
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 31-347 9.29e-64

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 206.12  E-value: 9.29e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  31 DQTRFRAYSREYAEVEPVVALYAQLLRVQGDLEGAQALLKDS-DPDMREMAVEEVRETKQQLVELEAQLqrmlLPKDPND 109
Cdd:PRK06746   9 DQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEyDEDLHEELESEVKGLIQEMNEYELQL----LLSDPYD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 110 GRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEILSENEGEHGGYKEVIARVEGDSVYGKLKFESGAHRVQRV 189
Cdd:PRK06746  85 KNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 190 PETESQGRIHTSACTVAVLPEPDEQQAIEINPADLRVDTYRSSGAGGQHVNKTDSAIRITHLPSGIVVECQEERSQHKNR 269
Cdd:PRK06746 165 SPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNR 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 270 ARAMSWLSAKLND---QQTSAAANAIASERKlLVGSGdrsERIRTYNF-PQGRVTDHRVNLTLYSLDEVLAGGVDAVIEP 345
Cdd:PRK06746 245 EHAMKMLKAKLYQkklEEQQAELDEIRGEQK-EIGWG---SQIRSYVFhPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 320


                 ..
gi 489500033 346 LL 347
Cdd:PRK06746 321 YL 322
PCRF smart00937
This domain is found in peptide chain release factors;
66-180 9.11e-61

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 190.75  E-value: 9.11e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033    66 QALLKDSDPDMREMAVEEVRETKQQLV-ELEAQLQRMLLPKDPNDGRNVFLEIRAGTGGDEAAIFSGDLFRMYSRYAERR 144
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEAELEeELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 489500033   145 GWRVEILSENEGEHGGYKEVIARVEGDSVYGKLKFE 180
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 217-323 9.29e-59

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 185.32  E-value: 9.29e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  217 IEINPADLRVDTYRSSGAGGQHVNKTDSAIRITHLPSGIVVECQEERSQHKNRARAMSWLSAKLNDQQtsAAANAIASER 296
Cdd:pfam00472   5 IEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELE--EEKEEEKKRR 82

                          90       100
                  ....*....|....*....|....*....
gi 489500033  297 -KLLVGSGDRSERIRTYNF-PQGRVTDHR 323
Cdd:pfam00472  83 iKSQVGSGDRSEQIRTYNFkPQSRVKDHR 111
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 217-323 5.54e-33

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 119.85  E-value: 5.54e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 217 IEINPADLRVDTYRSSGAGGQHVNKTDSAIRITH------------LPSGIVVECQEERSQHKNRARAMSWLSAKLND-- 282
Cdd:COG1186   21 IEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEae 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 489500033 283 --QQTSAAANAIASERKllvgsgDRSE--RIRtynfpqGRVTDHR 323
Cdd:COG1186  101 lePKERRATKPTRGSKK------RRLWgkQIR------SMVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 113-312 1.94e-29

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 112.17  E-value: 1.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  113 VFLEIRAGTGGDEAAIFSGDLFRMYSRYAERRGWRVEILSENEGEHGGYKEviarvegdSVYGKLKFESGAHRVQRVPET 192
Cdd:TIGR03072   1 ILLQLSSAQGPAECCLAVAKALERLTREAAARGVRVEVLEQEPGEVPGTLR--------SALVSLDGEAAAALADRWEGT 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033  193 -----ESQGRIHTSACT--VAVLPEPDEQqaiEINPADLRVDTYRSSGAGGQHVNKTDSAIRITHLPSGIVVECQEERSQ 265
Cdd:TIGR03072  73 llwicPSPYRPHHRRKNwfIGVQRFSASE---EATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQ 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 489500033  266 HKNRARAMSWLSAKLNDQQTSAAAnAIASERKLLVGSGDRSERIRTY 312
Cdd:TIGR03072 150 HANKRLATLLLAVRLADLQQEQAA-ALRAERRTAHHQIERGNPVRVF 195
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
217-278 1.54e-10

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 58.62  E-value: 1.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489500033 217 IEINPADLRVDTYRSSGAGGQHVNKTDSA------IRITHLP-----------------SG-IVVECQEERSQHKNRARA 272
Cdd:PRK09256   8 LVIPENELEWRFIRASGPGGQNVNKVSTAvelrfdIAASSLPefykerllalaghritkDGvIVIKAQEFRSQERNREDA 87


                 ....*.
gi 489500033 273 MSWLSA 278
Cdd:PRK09256  88 LERLVA 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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